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https://www.readbyqxmd.com/read/29929040/global-analysis-of-ubiquitome-in-prrsv-infected-pulmonary-alveolar-macrophages
#1
Huan Zhang, Liurong Fang, Xinyu Zhu, Dang Wang, Shaobo Xiao
Protein lysine ubiquitination is a dynamic reversible post-translational modification that plays key roles in modulating different cellular processes. Porcine reproductive and respiratory syndrome virus (PRRSV) is a notorious pathogen, causing tremendous economic losses for the global swine industry. The possible involvement of ubiquitination in PRRSV infection is unclear. So anti-ubiquitination-based enrichment and LC-MS were performed to investigate the global ubiquitination events triggered by PRRSV infection in pulmonary alveolar macrophages...
June 18, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29928941/nosocomial-outbreak-of-candida-parapsilosis-sensu-stricto-fungemia-in-a-neonatal-intensive-care-unit-in-china
#2
Lihua Qi, Weihong Fan, Xian Xia, Lu Yao, Lirui Liu, Haiyan Zhao, Xiangyong Kong, Jie Liu
BACKGROUND: Candida parapsilosis is a common agew2nt of fungemia, but few outbreaks of Candida parapsilosis infection have been reported in China. AIM: This study aimed to elaborate an outbreak of nosocomial Candida parapsilosis sensu stricto fungemia in a neonatal intensive care unit (NICU) of a comprehensive hospital in China from July to October 2017. METHODS: Epidemics and characteristics of fungemia cases were investigated. Surveillance samples were collected...
June 18, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29928920/joker-an-algorithm-to-insert-patterns-into-sequences-for-designing-antimicrobial-peptides-antimicrobial-peptides
#3
William F Porto, Isabel C M Fensterseifer, Suzana M Ribeiro, Octavio L Franco
The rise of bacterial resistance makes it necessary to find innovative alternatives to control bacterial infections. Antimicrobial peptides (AMPs) have been considered as the new generation of antimicrobial agents. Based on the fact that AMPs are sequence-dependent, a linguistic model for designing AMPs was previously developed. That model considers AMPs as a formal language with a grammar (patterns or motifs) and a vocabulary (amino acids). Albeit promising, that model has been poorly exploited mainly because it generates thousands of sequences, and the outcome has high similarity to already known AMPs...
June 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29928755/prophylactic-abdominal-drainage-for-pancreatic-surgery
#4
REVIEW
Wei Zhang, Sirong He, Yao Cheng, Jie Xia, Mingliang Lai, Nansheng Cheng, Zuojin Liu
BACKGROUND: The use of surgical drains has been considered mandatory after pancreatic surgery. The role of prophylactic abdominal drainage to reduce postoperative complications after pancreatic surgery is controversial. OBJECTIVES: To assess the benefits and harms of routine abdominal drainage after pancreatic surgery, compare the effects of different types of surgical drains, and evaluate the optimal time for drain removal. SEARCH METHODS: For the last version of this review, we searched CENTRAL (2016, Issue 8), and MEDLINE, Embase, Science Citation Index Expanded, and Chinese Biomedical Literature Database (CBM) to 28 August 2016)...
June 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29928745/modeling-the-role-of-public-health-education-in-ebola-virus-disease-outbreaks-in-sudan
#5
Benjamin Levy, Christina Edholm, Orou Gaoue, Roselyn Kaondera-Shava, Moatlhodi Kgosimore, Suzanne Lenhart, Benjamin Lephodisa, Edward Lungu, Theresia Marijani, Farai Nyabadza
Public involvement in Ebola Virus Disease (EVD) prevention efforts is key to reducing disease outbreaks. Targeted education through practical health information to particular groups and sub-populations is crucial to controlling the disease. In this paper, we study the dynamics of Ebola virus disease in the presence of public health education with the aim of assessing the role of behavior change induced by health education to the dynamics of an outbreak. The power of behavior change is evident in two outbreaks of EVD that took place in Sudan only 3 years apart...
August 2017: Infectious Disease Modelling
https://www.readbyqxmd.com/read/29928744/a-new-epidemic-modeling-approach-multi-regions-discrete-time-model-with-travel-blocking-vicinity-optimal-control-strategy
#6
Omar Zakary, Mostafa Rachik, Ilias Elmouki
First, we devise in this paper, a multi-regions discrete-time model which describes the spatial-temporal spread of an epidemic which starts from one region and enters to regions which are connected with their neighbors by any kind of anthropological movement. We suppose homogeneous Susceptible-Infected-Removed (SIR) populations, and we consider in our simulations, a grid of colored cells, which represents the whole domain affected by the epidemic while each cell can represent a sub-domain or region. Second, in order to minimize the number of infected individuals in one region, we propose an optimal control approach based on a travel-blocking vicinity strategy which aims to control only one cell by restricting movements of infected people coming from all neighboring cells...
August 2017: Infectious Disease Modelling
https://www.readbyqxmd.com/read/29928658/impact-of-zika-virus-on-adult-human-brain-structure-and-functional-organization
#7
Richard Bido-Medina, Jonathan Wirsich, Minelly Rodríguez, Jairo Oviedo, Isidro Miches, Pamela Bido, Luis Tusen, Peter Stoeter, Sepideh Sadaghiani
Objective: To determine the impact of Zika virus (ZIKV) infection on brain structure and functional organization of severely affected adult patients with neurological complications that extend beyond Guillain-Barré Syndrome (GBS)-like manifestations and include symptoms of the central nervous system (CNS). Methods: In this first case-control neuroimaging study, we obtained structural and functional magnetic resonance images in nine rare adult patients in the subacute phase, and healthy age- and sex-matched controls...
June 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29928531/strengthening-human-immunodeficiency-virus-and-tuberculosis-prevention-capacity-among-south-african-healthcare-workers-a-mixed-methods-study-of-a-collaborative-occupational-health-program
#8
Alexandre Liautaud, Prince A Adu, Annalee Yassi, Muzimkhulu Zungu, Jerry M Spiegel, Angeli Rawat, Elizabeth A Bryce, Michelle C Engelbrecht
Background: Insufficient training in infection control and occupational health among healthcare workers (HCWs) in countries with high human immunodeficiency virus (HIV) and tuberculosis (TB) burdens requires attention. We examined the effectiveness of a 1-year Certificate Program in Occupational Health and Infection Control conducted in Free State Province, South Africa in an international partnership to empower HCWs to become change agents to promote workplace-based HIV and TB prevention...
June 2018: Safety and Health At Work
https://www.readbyqxmd.com/read/29928280/tfh1-cells-in-germinal-centers-during-chronic-hiv-siv-infection
#9
REVIEW
Vijayakumar Velu, Geetha Mylvaganam, Chris Ibegbu, Rama Rao Amara
T follicular helper CD4 cells (Tfh) are essential for the development and maintenance of germinal center (GC) reactions, a critical process that promotes the generation of long-lived high affinity humoral immunity. It is becoming increasingly evident that GC-Tfh cells are heterogeneous in nature with some cellular characteristics associated with a Th1, Th2, and Th17 phenotype. Emerging studies suggest that GC-Tfh cells are directed to differentiate into distinct phenotypes during chronic HIV/SIV infection and these changes in GC-Tfh cells can greatly impact the B cell response and subclass of antibodies generated...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29928278/functions-of-cd1d-restricted-invariant-natural-killer-t-cells-in-antimicrobial-immunity-and-potential-applications-for-infection-control
#10
REVIEW
Yuki Kinjo, Shogo Takatsuka, Naoki Kitano, Shun Kawakubo, Masahiro Abe, Keigo Ueno, Yoshitsugu Miyazaki
CD1d-restricted invariant natural killer T ( i NKT) cells are innate-type lymphocytes that express a T-cell receptor (TCR) containing an invariant α chain encoded by the Vα14 gene in mice and Vα24 gene in humans. These i NKT cells recognize endogenous, microbial, and synthetic glycolipid antigens presented by the major histocompatibility complex (MHC) class I-like molecule CD1d. Upon TCR stimulation by glycolipid antigens, i NKT cells rapidly produce large amounts of cytokines, including interferon-γ (IFNγ) and interleukin-4 (IL-4)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29928268/a-small-molecule-screening-pipeline-to-evaluate-the-therapeutic-potential-of-2-aminoimidazole-molecules-against-clostridium-difficile
#11
Rajani Thanissery, Daina Zeng, Raul G Doyle, Casey M Theriot
Antibiotics are considered to be the first line of treatment for mild to moderately severe Clostridium difficile infection (CDI) in humans. However, antibiotics are also risk factors for CDI as they decrease colonization resistance against C. difficile by altering the gut microbiota and metabolome. Finding compounds that selectively inhibit different stages of the C. difficile life cycle, while sparing the indigenous gut microbiota is important for the development of alternatives to standard antibiotic treatment...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29928206/integrated-diagnostic-model-that-incorporates-epstein-barr-virus-dna-imaging-and-nasal-endoscopy-to-stratify-primary-tumor-and-lymph-nodes-in-a-patient-with-n1-nasopharyngeal-carcinoma-multidisciplinary-management
#12
Paolo Gamba, Luigina Rota, C Abeni, Alessandra Huscher, Gabriele Saldi, Alberto Soregaroli, Elena Padolecchia, Fausto Zorzi, Mario Bignardi, Alberto Zaniboni
Nasopharyngeal carcinoma (NPC) is an epithelial malignancy, with a high metastatic potential. Epstein-Barr virus (EBV) infection plays a fundamental role, even if it is not well understood. The diagnosis of the disease in its early stage is infrequent. Imaging studies, positron emission tomography scans in addition to clinical examination, endoscopic examination, and biopsy provide information on the extent of the disease. The application of neoadjuvant chemotherapy followed by concomitant chemoradiation can improve the control of NPC...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29928074/a-breast-prosthesis-infection-update-two-year-incidence-risk-factors-and-management-at-single-institution
#13
Ashley Nadia Boustany, Shady Elmaraghi, Nneamaka Agochukwu, Benjamin Cloyd, Adam J Dugan, Brian Rinker
Background: Infection following augmentation and prosthetic-based breast reconstruction can cause significant physical and psychological distress for patients. It may delay adjuvant therapies and compromise aesthetic outcomes. The aim of this study is to identify modifiable risk factors for infection and identify common bacterial isolates to achieve optimal outcomes for patients. Methods: A retrospective cohort study was performed for patients undergoing implant-based breast reconstruction over a 2-year period...
January 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29927974/anti-filarial-immunity-blocks-parasite-development-and-plays-a-protective-role
#14
Prakash Kumar Sahoo, Santosh K Panda, Ashok Kumar Satapathy, Sanghamitra Pati
Lymphatic filariasis is a complex parasitic disease having a spectrum of clinical parameters which are critical in deciding the severity of the pathogenesis. Individuals residing in the endemic areas are categorized into different clinical groups such as: EC (endemic controls-free of disease and infection), AS (asymptomatic carriers- free of disease but carries both antigens and microfilaria (Mf) in circulation), CR (cryptic-free of disease and Mf but having circulatory antigen) and CH (chronic-having manifestations of elephantiasis and hydrocele)...
2018: PloS One
https://www.readbyqxmd.com/read/29927940/vector-competence-of-aedes-aegypti-culex-tarsalis-and-culex-quinquefasciatus-from-california-for-zika-virus
#15
Bradley J Main, Jay Nicholson, Olivia C Winokur, Cody Steiner, Kasen K Riemersma, Jackson Stuart, Ryan Takeshita, Michelle Krasnec, Christopher M Barker, Lark L Coffey
Zika virus (ZIKV) has emerged since 2013 as a significant global human health threat following outbreaks in the Pacific Islands and rapid spread throughout South and Central America. Severe congenital and neurological sequelae have been linked to ZIKV infections. Assessing the ability of common mosquito species to transmit ZIKV and characterizing variation in mosquito transmission of different ZIKV strains is important for estimating regional outbreak potential and for prioritizing local mosquito control strategies for Aedes and Culex species...
June 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29927705/epigenetic-variation-and-regulation-in-malaria-parasites
#16
Manoj T Duraisingh, Kristen M Skillman
Eukaryotic pathogens must survive in different hosts, respond to changing environments, and exploit specialized niches to propagate. Plasmodium parasites cause human malaria during bloodstream infections, where they must persist long enough to be transmitted. Parasites have evolved diverse strategies of variant gene expression that control critical biological processes of blood-stage infections, including antigenic variation, erythrocyte invasion, innate immune evasion, and nutrient acquisition, as well as life-cycle transitions...
June 21, 2018: Annual Review of Microbiology
https://www.readbyqxmd.com/read/29927699/international-experience-with-minocycline-edta-and-ethanol-lock-for-salvaging-of-central-line-associated-bloodstream-infections
#17
Ray Hachem, Souha Kanj, Nelson Hamerschlak, Hala Saad, Fernanda Ferraz Assir, Nobuyoshi Mori, Ying Jiang, Fady Ghaly, Anne Marie Chaftari, Issam I Raad
BACKGROUND: The use of long-term central venous catheters (CVCs) could lead to serious bloodstream infections. Removal of the infected CVC and reinsertion of a new CVC are not always feasible and alternative lock therapy may be considered. We conducted a multicenter trial to assess the efficacy and safety of the lock therapy. METHODS: Between October 2013 and August 2014, we prospectively enrolled 20 patients with catheter-related bloodstream infections (CRBSIs) or central line-associated bloodstream infections (CLABSIs) in our sister institutions in three countries including Brazil, Lebanon, and Japan...
June 2018: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29927458/the-influence-of-clinical-environmental-and-socioeconomic-factors-on-five-year-patient-survival-after-kidney-transplantation
#18
Priscila Ruppel, Claudia R Felipe, Jose O Medina-Pestana, Liliane Lumi Hiramoto, Laila Viana, Alexandra Ferreira, Wilson Aguiar, Mayara Ivani, Adrieli Bessa, Marina Cristelli, Melissa Gaspar, Helio Tedesco-Silva
INTRODUCTION: The risk of death after kidney transplant is associated with the age of the recipient, presence of comorbidities, socioeconomic status, local environmental characteristics and access to health care. OBJECTIVE: To investigate the causes and risk factors associated with death during the first 5 years after kidney transplantation. METHODS: This was a single-center, retrospective, matched case-control study. RESULTS: Using a consecutive cohort of 1,873 kidney transplant recipients from January 1st 2007 to December 31st 2009, there were 162 deaths (case group), corresponding to 5-year patient survival of 91...
June 4, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29927371/ribavirin-induced-mutagenesis-across-the-complete-open-reading-frame-of-hepatitis-c-virus-genotypes-1a-and-3a
#19
Niels Mejer, Ulrik Fahnøe, Andrea Galli, Santseharay Ramirez, Thomas Benfield, Jens Bukh
Ribavirin (RBV) has been used for the last 20 years to treat patients with chronic hepatitis C virus (HCV) infection. This pluripotent drug is believed to induce mutagenesis in HCV RNA. However, for cell-cultured HCV (HCVcc) this phenomenon has only been investigated in genotype 2a recombinants. Here we studied the mutations that developed in HCVcc of genotypes 1a and 3a treated with RBV or ribavirin triphosphate (RBV-TP) compared to non-treated controls. Analysis was performed on the amplified full-length open reading frame (ORF) of recovered viruses following next-generation sequencing and clonal analyses...
June 21, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29927116/glycocalyx-scaffolding-to-control-cell-surface-glycan-displays
#20
Mia L Huang, Ember M Tota, Stephen Verespy, Kamil Godula
This article describes a protocol for remodeling cells with synthetic glycoprotein and glycolipid mimetics that are functionalized with lipid anchors, allowing for cell surface display of specific glycan structures in predefined nanoscale arrangements. The complex chemical heterogeneity of glycans found on the cell surface or the glycocalyx renders analysis of the individual contributions of glycans difficult. This technique allows for the precise study of individual glycans at different regions of the glycocalyx, and may be useful for interrogating glycan interactions in infection or immunity or in stem cell differentiation...
June 2018: Current Protocols in Chemical Biology
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