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Rapid eye movement behavior disorder

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https://www.readbyqxmd.com/read/28215267/a-community-based-study-of-risk-factors-for-probable-rapid-eye-movement-sleep-behavior-disorder
#1
Jian-Fang Ma, Yuan Qiao, Xiang Gao, Liang Liang, Xiao-Li Liu, Dun-Hui Li, Hui-Dong Tang, Sheng-Di Chen
OBJECTIVES: To cross-sectionally explore the potential risk factors for rapid eye movement (REM) sleep behavior disorder (RBD) in a community cohort in Shanghai. METHODS: Based on the validated RBD screening questionnaire (RBDSQ), we identified individuals with probable RBD (pRBD) in 3635 community-dwelling residents (≥50 years old) from an urban community of Shanghai. Potential risk factors of pRBD, including age, sex, smoking, socioeconomic status, obesity, consumption of tea (surrogate for caffeine intake) and alcohol, medications and chronic disease status, were assessed via questionnaire...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28215258/familial-idiopathic-rapid-eye-movement-sleep-behavior-disorder
#2
Aurélie Pierre-Justin, Annie Lannuzel, Isabelle Arnulf
No abstract text is available yet for this article.
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28164375/pedunculopontine-network-dysfunction-in-parkinson-s-disease-with-postural-control-and-sleep-disorders
#3
Cecile Gallea, Claire Ewenczyk, Bertrand Degos, Marie-Laure Welter, David Grabli, Smaranda Leu-Semenescu, Romain Valabregue, Pierre Berroir, Lydia Yahia-Cherif, Eric Bertasi, Sara Fernandez-Vidal, Eric Bardinet, Emmanuel Roze, Habib Benali, Cyril Poupon, Chantal François, Isabelle Arnulf, Stéphane Lehéricy, Marie Vidailhet
BACKGROUND: The objective of this study was to investigate pedunculopontine nucleus network dysfunctions that mediate impaired postural control and sleep disorder in Parkinson's disease. METHODS: We examined (1) Parkinson's disease patients with impaired postural control and rapid eye movement sleep behavior disorder (further abbreviated as sleep disorder), (2) Parkinson's disease patients with sleep disorder only, (3) Parkinson's disease patients with neither impaired postural control nor sleep disorder, and (4) healthy volunteers...
February 6, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28160778/meta-analysis-on-the-prevalence-of-rem-sleep-behavior-disorder-symptoms-in-parkinson-s-disease
#4
Jia Zhang, Chuan-Ying Xu, Jun Liu
BACKGROUND: Our study was aimed to evaluate the risk of a selected non-motor symptom, namely rapid eye movement behavior disorder (RBD) symptoms, among patients with newly diagnosed Parkinson disease compared with health controls. METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for meta-analysis and Cochrane manual were followed. Studies on RBD symptoms and PD were searched using PubMed, Embase, Web of Science and Cochrane library databases...
February 4, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28132976/diagnosis-disease-notification-and-management-of-rapid-eye-movement-rem-sleep-behavior-disorder
#5
Takayoshi Shimohata, Yuichi Inoue, Koichi Hirata
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by dream enactment behavior during REM sleep. It has been demonstrated that patients with idiopathic RBD are at a significantly increased risk of developing one of the α-synucleinopathies later in life, and this is called "phenoconversion". Although some physicians argue against disclosing information that could cause patients psychological stress, the patients also have a "right to know" about their own disease. Therefore, determining when and how to disclose this information, in addition to appropriate follow-up, is important...
January 28, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28131178/cortical-control-of-vertical-and-horizontal-saccades-in-progressive-supranuclear-palsy-an-exploratory-fmri-study
#6
J Lemos, D Pereira, L Almendra, D Rebelo, M Patrício, J Castelhano, G Cunha, C Januário, L Cunha, A Freire, M Castelo-Branco
Progressive supranuclear palsy (PSP) is a neurodegenerative disorder showing predominant brainstem involvement, characterized by marked slowing of rapid eye movements (saccades), particularly along the vertical plane. While the contribution of the brainstem damage for the saccadic disturbance in PSP has been extensively studied, much less is known about its cortical and subcortical pathomechanisms. We measured reflexive (prosaccades) and voluntary (antisaccades) saccades in the vertical and horizontal plane in PSP patients (n=8) and controls (n=10) in an eye tracking study, followed by the measurement of blood oxygenation-level dependent (BOLD) activation (PSP, n=6; controls, n=10) during similar saccade paradigms...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28128401/expression-of-prion-protein-in-the-cerebrospinal-fluid-of-patients-with-parkinson-s-disease-complicated-with-rapid-eye-movement-sleep-behavior-disorder
#7
W J Zhang, X L Shang, J Peng, M H Zhou, W J Sun
Parkinson's disease (PD) is one of the most common neurodegenerative diseases and mainly manifests with decreasing numbers of dopaminergic neurons. Rapid eye movement (REM) sleep behavior disorder (RBD) has an incidence of 15-47% in all PD patients. Prion proteins (PrPs), which are expressed in both neurons and glial cells of the brain, are believed to be correlated with abnormal neurological functions, although their role in PD-related sleeping disorders remains unclear. We therefore investigated the expressional profiles of PrP in PD patients with RBD...
January 23, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28090684/predict-pd-an-online-approach-to-prospectively-identify-risk-indicators-of-parkinson-s-disease
#8
Alastair J Noyce, Lea R'Bibo, Luisa Peress, Jonathan P Bestwick, Kerala L Adams-Carr, Niccolo E Mencacci, Christopher H Hawkes, Joseph M Masters, Nicholas Wood, John Hardy, Gavin Giovannoni, Andrew J Lees, Anette Schrag
BACKGROUND: A number of early features can precede the diagnosis of Parkinson's disease (PD). OBJECTIVE: To test an online, evidence-based algorithm to identify risk indicators of PD in the UK population. METHODS: Participants aged 60 to 80 years without PD completed an online survey and keyboard-tapping task annually over 3 years, and underwent smell tests and genotyping for glucocerebrosidase (GBA) and leucine-rich repeat kinase 2 (LRRK2) mutations...
February 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28019055/quality-of-life-in-patients-with-an-idiopathic-rapid-eye-movement-sleep-behaviour-disorder-in-korea
#9
Keun Tae Kim, Gholam K Motamedi, Yong Won Cho
There have been few quality of life studies in patients with idiopathic rapid eye movement sleep behaviour disorder. We compared the quality of life in idiopathic rapid eye movement sleep behaviour disorder patients to healthy controls, patients with hypertension, type 2 diabetes mellitus without complication and idiopathic restless legs syndrome. Sixty patients with idiopathic rapid eye movement sleep behaviour disorder (24 female; mean age: 61.43 ± 8.99) were enrolled retrospectively. The diagnosis was established based on sleep history, overnight polysomnography, neurological examination and Mini-Mental State Examination to exclude secondary rapid eye movement sleep behavior disorder...
December 26, 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/28007355/isolated-rapid-eye-movement-sleep-without-atonia-in-amyotrophic-lateral-sclerosis
#10
Monica Puligheddu, Patrizia Congiu, Debora Aricò, Francesco Rundo, Giuseppe Borghero, Francesco Marrosu, Maria Livia Fantini, Raffaele Ferri
OBJECTIVE: The aim of this study was to quantitatively analyze, with the most recent and advanced tools, the presence of periodic leg movements during sleep (PLMS) and/or rapid eye movement (REM) sleep without atonia (RSWA), in a group of patients with amyotrophic lateral sclerosis (ALS), and to assess their eventual correlation with the clinical severity of the disease. METHODS: Twenty-nine ALS patients were enrolled (mean age 63.6 years) along with 28 age-matched "normal" controls (mean age 63...
October 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27977578/nonmotor-symptoms-in-patients-with-parkinson-disease-a-cross-sectional-observational-study
#11
Tie-Mei Zhang, Shu-Yang Yu, Peng Guo, Yang Du, Yang Hu, Ying-Shan Piao, Li-Jun Zuo, Teng-Hong Lian, Rui-Dan Wang, Qiu-Jin Yu, Zhao Jin, Wei Zhang
Parkinson disease (PD) is usually accompanied by numerous nonmotor symptoms (NMS), such as neuropsychiatric symptoms, sleep disorders, autonomic dysfunctions, and sensory disturbances. However, it is not clear that the factors influencing the occurrence of NMS and its sequence with motor symptoms (MS).We conducted comprehensive assessments of NMS by using 13 scales in 1119 PD patients.A total of 70.8% PD patients present NMS. Olfactory dysfunction tends to occur in PD patients with older age, more severe depression, sleep problems, and autonomic dysfunctions...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27957531/noradrenaline-from-locus-coeruleus-neurons-acts-on-pedunculo-pontine-neurons-to-prevent-rem-sleep-and-induces-its-loss-associated-effects-in-rats
#12
Mudasir Ahmad Khanday, Bindu I Somarajan, Rachna Mehta, Birendra Nath Mallick
Normally, rapid eye movement sleep (REMS) does not appear during waking or non-REMS. Isolated, independent studies showed that elevated noradrenaline (NA) levels inhibit REMS and induce REMS loss-associated cytomolecular, cytomorphological, psychosomatic changes and associated symptoms. However, the source of NA and its target in the brain for REMS regulation and function in health and diseases remained to be confirmed in vivo. Using tyrosine hydroxylase (TH)-siRNA and virus-coated TH-shRNA in normal freely moving rats, we downregulated NA synthesis in locus coeruleus (LC) REM-OFF neurons in vivo...
November 2016: ENeuro
https://www.readbyqxmd.com/read/27923423/comparison-between-automatic-and-visual-scorings-of-rem-sleep-without-atonia-for-the-diagnosis-of-rem-sleep-behavior-disorder-in-parkinson-disease
#13
Michela Figorilli, Raffaele Ferri, Maurizio Zibetti, Patricia Beudin, Monica Puligheddu, Leonardo Lopiano, Alessandro Cicolin, Frank Durif, Ana Marques, Maria Livia Fantini
STUDY OBJECTIVES: To compare three different methods, two visual and one automatic, for the quantification of rapid eye movement (REM) sleep without atonia (RSWA) in the diagnosis of REM sleep behavior disorder (RBD) in Parkinson's disease (PD) patients. METHODS: Sixty-two consecutive patients with idiopathic PD underwent videopolysomnographic recording and showed more than 5 minutes of REM sleep. The electromyogram (EMG) during REM sleep was analyzed by means of two visual methods (Montréal and SINBAR) and one automatic analysis (REM Atonia Index or RAI)...
November 28, 2016: Sleep
https://www.readbyqxmd.com/read/27912885/tetrandrine-an-alkaloid-from-s-tetrandra-exhibits-anti-hypertensive-and-sleep-enhancing-effects-in-shr-via-different-mechanisms
#14
Yuan-Li Huang, Su-Ying Cui, Xiang-Yu Cui, Qing Cao, Hui Ding, Jin-Zhi Song, Xiao Hu, Hui Ye, Bin Yu, Zhao-Fu Sheng, Zi-Jun Wang, Yong-He Zhang
BACKGROUND: Sleep disorders have been found to be associated with hypertension in both cross-sectional and longitudinal epidemiological studies. Tetrandrine, a major component of Stephania tetrandra, is well known as an antihypertensive agent. The anti-hypertension mechanism mainly relies on its L-type calcium channel blocking property. In the previous study, tetrandrine revealed both anti-hypertension and hypnotic effects in spontaneously hypertensive rats (SHRs). PURPOSE: This study aims to elucidate whether the antihypertensive mechanism of tetrandrine in SHRs is relevant to its hypnotic effect...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27905363/-sleep-disorders-in-the-early-stage-of-parkinson-s-disease-in-untreated-patients
#15
N A Amosova, I G Smolentseva, P M Guseinova, O A Maslyuk, E L Gavrilov
Disorders of sleep and wakefulness occur in about 60-98% of patients with Parkinson's disease (PD). The majority of research on the scale and nature of the disorders was performed in patients treated with antiparkinsonian drugs, and, therefore, the true picture of sleep disorders was interfering with side effects of therapy. The spectrum of these disorders in PD patients is broad and includes insomnia, parasomnia and hypersomnia. The main symptoms of insomnia are difficulty in maintaining sleep, associated with nocturia, rapid eye movement (REM) sleep behavior disorder (RBD), night cramps, akinesia and tremor...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27894921/alterations-of-awake-eeg-in-idiopathic-rem-sleep-behavior-disorder-without-cognitive-impairment
#16
Young Rong Bang, Hong Jun Jeon, Soyoung Youn, In-Young Yoon
The aim of this study was to find electroencephalographic (EEG) changes in subjects with drug-naïve idiopathic rapid eye movement sleep behavior disorder (iRBD) who had no cognitive impairment. A total of 57 iRBD patients confirmed by polysomnography (PSG) and 33 sex and age-matched healthy controls were included and their waking EEG was recorded from five cortical regions for 15min. Power spectral analyses by fast Fourier transforms were performed on EEG data. In PSG data, the iRBD patients showed sleep disturbances of short total sleep time, decreased sleep efficiency, increased sleep latency and frequent awakening compared to controls...
January 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/27888574/normal-heart-in-parkinson-s-disease-is-this-a-distinct-clinical-phenotype
#17
J-S Kim, H-E Park, I-S Park, Y-S Oh, D-W Ryu, I-U Song, Y-A Jung, I R Yoo, H-S Choi, P H Lee, K-S Lee
BACKGROUND AND PURPOSE: Reduction of metaiodobenzylguanidine (MIBG) uptake has been observed in almost all patients with Parkinson's disease (PD), associated with hyposmia, orthostatic hypotension and rapid eye movement sleep behavioral disorder (RBD). In contrast, a subgroup of patients with PD with normal MIBG uptake have been reported to have milder disease and preserved cognition compared with those with lower MIBG. The aim of this study was to investigate whether non-motor manifestations of PD differ between patients with normal and abnormal myocardial MIBG uptake...
February 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27880010/abnormal-baseline-brain-activity-in-parkinson-s-disease-with-and-without-rem-sleep-behavior-disorder-a-resting-state-functional-mri-study
#18
Dan Li, Peiyu Huang, Yufeng Zang, Yuting Lou, Zhidong Cen, Quanquan Gu, Min Xuan, Fei Xie, Zhiyuan Ouyang, Bo Wang, Minming Zhang, Wei Luo
PURPOSE: To investigate the differences in spontaneous brain activity between Parkinson's disease (PD) patients with rapid eye movement sleep behavior disorder (RBD), PD patients without RBD, and normal controls, which may shed new light on the neural mechanism of RBD. MATERIALS AND METHODS: Eighteen PD patients with RBD, 16 patients without RBD, and 19 age- and gender-matched normal controls underwent clinical assessment and functional magnetic resonance imaging (fMRI) with a 3...
November 23, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27873359/constipation-in-parkinson-s-disease-subjective-symptoms-objective-markers-and-new-perspectives
#19
REVIEW
Karoline Knudsen, Klaus Krogh, Karen Østergaard, Per Borghammer
Constipation is among the first nonmotor symptoms to develop in the prodromal phase of PD. Pathological alpha-synuclein deposition is present throughout the gastrointestinal tract up to 20 years preceding diagnosis. Nevertheless, constipation in the context of PD remains ill defined and poorly understood. In this review, we summarize current knowledge of subjective symptoms and objective measures of constipation in PD. More than 10 different definitions of constipation have been used in the PD literature, making generalizations difficult...
November 22, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27855735/pareidolias-in-rem-sleep-behavior-disorder-a-possible-predictive-marker-of-lewy-body-diseases
#20
Taeko Sasai-Sakuma, Yoshiyuki Nishio, Kayoko Yokoi, Etsuro Mori, Yuichi Inoue
STUDY OBJECTIVES: To investigate conditions and clinical significance of pareidolias in patients with idiopathic REM sleep behavior disorder (iRBD). METHODS: This cross-sectional study examined 202 patients with idiopathic rapid eye movement sleep behavior disorder (66.8±8.0 yr, 58 female) and 46 healthy control subjects (64.7±5.8 yr, 14 female). They underwent the Pareidolia test, a newly developed instrument for evoking pareidolias, video-polysomnography, olfactory tests, and Addenbrooke's cognitive examination - revised...
October 28, 2016: Sleep
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