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https://www.readbyqxmd.com/read/28339735/triage-quality-control-is-missing-tools-a-new-observation-technique-for-ed-quality-improvement
#1
Tomi Malmström, Veli-Pekka Harjola, Paulus Torkki, Salla Kumpulainen, Raija Malmström
Objective: Correct assessment of patient urgency is critical to ensuring patient safety in emergency departments (EDs). Although significant time and effort have been devoted to developing triage systems, less attention has been paid to the development of quality control. The aim of this study is to introduce and test observation technique, which enables identifying of patient groups at risk of erroneous assessment in triage. The introduced technique is aimed to be less laborious to use than existing triage quality control methods...
February 23, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28332666/direct-observation-of-breathing-dynamics-at-the-mismatch-induced-dna-bubble-with-nanometre-accuracy-a-smfret-study
#2
Tapas Paul, Subhas C Bera, Padmaja P Mishra
The detailed conformational dynamics of the melted region in double-stranded DNA has been studied using a combination of ensemble and single-molecule FRET techniques. We monitored the millisecond time scale fluctuation kinetics of the two strands at the bubble region that varies with the size of the bubble. As the individual strands at the melting bubble behave as single-stranded DNA, and hence fluctuate dynamically to attain energetically favored configurations, the rates of these fluctuations increase with increase in the bubble size...
March 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28330714/rapid-maxillary-expansion-in-mouth-breathers-a-short-term-skeletal-and-soft-tissue-effect-on-the-nose
#3
Fauze Ramez Badreddine, Reginaldo R Fujita, Fabio Eduardo Maiello Monteiro Alves, Mario Cappellette
INTRODUCTION: Rapid maxillary expansion (RME) can change the form and function of the nose. The skeletal and soft tissue changes can influence the esthetics and the stability of the results obtained by the RME. OBJECTIVE: The aim of this retrospective study was to evaluate the short-term effects of RME on the skeletal and soft tissue structures of the nose, in mouth-breathing patients, using a reliable and reproducible, but simple methodology, with the aid of computed tomography...
February 24, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28330428/toxicity-of-airborne-dust-as-an-indicator-of-moisture-problems-in-school-buildings
#4
Jenni Tirkkonen, Martin Täubel, Hanna Leppänen, Matti Peltonen, William Lindsley, Bean T Chen, Anne Hyvärinen, Maija-Riitta Hirvonen, Kati Huttunen
Moisture-damaged indoor environments are thought to increase the toxicity of indoor air particulate matter (PM), indicating that a toxicological assay could be used as a method for recognizing buildings with indoor air problems. We aimed to test if our approach of analyzing the toxicity of actively collected indoor air PM in vitro differentiates moisture-damaged from non-damaged school buildings. We collected active air samples with NIOSH Bioaerosol Cyclone Samplers from moisture-damaged (index) and non-damaged (reference) school buildings (4 + 4)...
February 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28327946/draft-genome-of-the-northern-snakehead-channa-argus
#5
Jian Xu, Chao Bian, Kunci Chen, Guiming Liu, Yanliang Jiang, Qing Luo, Xinxin You, Wenzhu Peng, Jia Li, Yu Huang, Yunhai Yi, Chuanju Dong, Hua Deng, Songhao Zhang, Hanyuan Zhang, Qiong Shi, Peng Xu
Background: The Northern snakehead ( Channa argus ), a member of the Channidae family of the Perciformes, and is an economically important freshwater fish native to East Asia. In North America, it has become notorious as an intentionally released invasive species. Its ability to breathe air with gills and migrate short distances over land makes it a good model for bimodal breath research. Therefore, recent research has focused on the identification of relevant candidate genes. Here, we performed whole genome sequencing of C...
March 2, 2017: GigaScience
https://www.readbyqxmd.com/read/28327896/a-randomised-phase-iii-study-of-72%C3%A2-hour-infusional-versus-bolus-bleomycin-in-bep-bleomycin-etoposide-and-cisplatin-chemotherapy-to-treat-igcccg-good-prognosis-metastatic-germ-cell-tumours-te-3
#6
J Shamash, S-J Sarker, R Huddart, S Harland, J K Joffe, D Mazhar, A Birtle, J White, K Chowdhury, P Wilson, M R Marshall, S Vinnicombe
Background: Bleomycin is an integral part of combination chemotherapy in germ cell tumours. Pulmonary toxicity often necessitates drug cessation and death occurs in 1-2% of patients. A continuous infusion of bleomycin might reduce lung toxicity when compared to the conventional weekly boluses given as part of standard BEP chemotherapy. Patients and Methods: A phase 3 trial was conducted based on 212 men with IGCCCG good prognosis metastatic germ cell tumours with 1:1 randomisation...
February 21, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28323624/conventional-or-natural-pharmacotherapy-and-the-prevalence-of-anxiety-and-depression-during-menopause
#7
Dorota Kopciuch, Anna Paczkowska, Tomasz Zaprutko, Michał Michalak, Elżbieta Nowakowska
Context • Psychoneurological symptoms are present in nearly all women in the perimenopausal period. Key elements of care in the period may include hormone replacement therapy (HRT). Alternatively, phytoestrogens, antidepressant pharmacotherapy, or a combination of hormonal and antidepressant therapies may be recommended. Objective • The study intended to verify whether women who are menopausal believe that a reduction in their symptoms of anxiety and depression depends on the type of pharmacotherapy used...
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28321966/sleep-disordered-breathing-in-chronic-heart-failure-is-highly-variable-when-measured-remotely-using-a-novel-non-contact-biomotion-sensor
#8
Kenneth McDonald, Rory O'Hanlon, Henry Oluwasefunmi Savage, Rami N Khushaba, Michael Colefax, Steven Farrugia, Faizan Javed, Klaus Schindhelm, Ian Wilcox, Martin R Cowie
We used a remotely monitored non-contact biosensor (SleepMinder™) to measure breathing during sleep (SDB) in a prospective study of 91 patients with stable class II to IV heart failure (HF). The device algorithm measures a surrogate of the traditional apnoea/hypopnoea index (AHI) measured in polysomnographic sleep studies. Data was transmitted daily to a central monitoring centre and analysed in consecutive 2-week blocks. A total of 37 465 nights over 3-24 months was analysed. An AHI of >15/h was considered clinically significant...
March 21, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28321308/late-presentation-of-an-anomalous-left-coronary-artery-from-the-pulmonary-artery-treated-with-conservative-surgical-management-with-long-term-cardiac-magnetic-resonance-imaging-follow-up
#9
Pishoy Gouda, John Gouda, Craig Butler, Robert C Welsh
Anomalous origin of the left coronary artery from the pulmonary artery is rare congenital abnormality that most commonly presents in childhood and is associated with a high mortality. In the elderly, patients may present acutely with arrhythmias or signs of ischemia or with vague chronic presentations of shortness of breath and fatigue. In the high-risk elderly population, it is unclear as to whether conservative surgical management by means of suture ligation of the left coronary artery is associated with positive long-term outcomes...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28319126/effects-of-sevoflurane-and-clonidine-on-acid-base-status-and-long-term-emotional-and-cognitive-outcomes-in-spontaneously-breathing-rat-pups
#10
Nicole Almenrader, Paola Colucci, Valentina De Castro, Daniela Valeri, Maura Palmery, Viviana Trezza, Patrizia Campolongo
BACKGROUND: Numerous experiments in rodents suggest a causative link between exposure to general anaesthetics during brain growth spurt and poor long-lasting neurological outcomes. Many of these studies have been questioned with regard of their translational value, mainly because of extremely long anaesthesia exposure. Therefore, the aim of the present study was to assess the impact of a short sevoflurane anaesthesia, alone or combined with clonidine treatment, on respiratory function in spontaneously breathing rat pups and overall effects on long-lasting emotional and cognitive functions...
2017: PloS One
https://www.readbyqxmd.com/read/28314809/goodpasture-s-disease-with-late-presentation-of-renal-abnormality-and-anti-gbm-autoantibody
#11
Emily Ann Boardman, Sameira Sohail, Rajesh Yadavilli
Goodpasture's disease without circulating autoantibodies is a rare presentation of a rare diagnosis. We present the case of a man aged 17 years who had 3 hospital admissions over a 2-month period with haemoptysis and shortness of breath. Throughout his first 2 admissions, his renal function was normal and anti-glomerular basement membrane (GBM) antibodies were negative. CT pulmonary angiogram during his second admission revealed florid and diffuse alveolar infiltrates. However, high-resolution CT chest performed 4 weeks later showed complete resolution of these changes...
March 17, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28314215/a-metabolomic-approach-shows-sphingosine-1-phosphate-and-lysophospholipids-as-mediators-of-the-therapeutic-effect-of-liver-growth-factor-in-emphysema
#12
A Navarrete, F J Rupérez, T O Mendes, S Pérez-Rial, A Girón-Martínez, R Terrón-Expósito, J J Díaz-Gil, G Peces-Barba, C Barbas, A García
Tobacco smoke exposure is the principal cause of lung tissue destruction, which in turn results in emphysema that leads into shortness of breath. Liver growth factor (LGF, a cell and tissue regenerating factor with therapeutic activity in several organs) has antifibrotic and antioxidant properties that could be useful to promote lung tissue regenerating capacity in damaged lungs. The current study has examined differences in metabolite profiles (fingerprints) of plasma from mice (strain C57BL/6J, susceptible to develop emphysema) exposed to tobacco smoke during six months...
February 27, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28302246/cardiac-amorphous-tumour-cat-presenting-with-thrombocytopenia
#13
Afra Samad, Arbaz Samad, Khurram Shafique
Cardiac calcified amorphous tumour (CAT) is a rare non-neoplastic lesion with only a few cases reported in literature. We present an interesting case of CAT that was associated with unexpectedly low platelet count. A 40-year man presented with shortness of breath on exertion. Echocardiogram showed a mobile mass within the right atrium. Mass was surgically excised. His platelet count varied from 26,000/ul to 54,000/ul before surgery, which increased postoperatively. Histopathological examination revealed amorphous mass of eosinophilic fibrin with dense calcification...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28301447/mercury-spill-responses-five-states-2012-2015
#14
Ryan J Wozniak, Anne E Hirsch, Christina R Bush, Stuart Schmitz, Jeff Wenzel
Despite measures to educate the public about the dangers of elemental mercury, spills continue to occur in homes, schools, health care facilities, and other settings, endangering the public's health and requiring costly cleanup. Mercury is most efficiently absorbed by the lungs, and exposure to high levels of mercury vapor after a release can cause cough, sore throat, shortness of breath, nausea, vomiting, diarrhea, headaches, and visual disturbances (1). Children and fetuses are most susceptible to the adverse effects of mercury vapor exposure...
March 17, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28300332/computer-vision-based-diameter-maps-to-study-fluoroscopic-recordings-of-small-intestinal-motility-from-conscious-experimental-animals
#15
I Ramírez, J J Pantrigo, A S Montemayor, A E López-Pérez, M I Martín-Fontelles, S J H Brookes, R Abalo
BACKGROUND: When available, fluoroscopic recordings are a relatively cheap, non-invasive and technically straightforward way to study gastrointestinal motility. Spatiotemporal maps have been used to characterize motility of intestinal preparations in vitro, or in anesthetized animals in vivo. Here, a new automated computer-based method was used to construct spatiotemporal motility maps from fluoroscopic recordings obtained in conscious rats. METHODS: Conscious, non-fasted, adult, male Wistar rats (n=8) received intragastric administration of barium contrast, and 1-2 hours later, when several loops of the small intestine were well-defined, a 2 minutes-fluoroscopic recording was obtained...
March 16, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28297814/-igg4-related-lung-disease-analysis-of-8-cases-and-literature-review
#16
G J Han, H Hu, D Mao, X Bai, D Y She, S F Zhao, Z L Wen, J Gao
Objective: To improve the understanding and treatment of IgG4-related lung disease (IgG4-RLD). Methods: The clinical characteristics, serum IgG4 levels, pathological features, chest CT, therapy and prognosis of 8 patients with IgG4-RLD were retrospectively analyzed. These patients were admitted to the People's Liberation Army General Hospital and the pathological diagnosis was made between December 2005 and March 2016. Relevant literatures were reviewed. Results: The 8 patients with IgG4-RLD included 4 men and 4 women, with an average age of (59±4) years (range, 37-74)...
March 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28294285/evaluation-of-a-flexible-bronchoscope-prototype-designed-for-bronchoscopy-during-mechanical-ventilation-a-proof-of-concept-study
#17
M-A Nay, A Auvet, J Mankikian, V Herve, P-F Dequin, A Guillon
Bronchoscopy during mechanical ventilation of patients' lungs significantly affects ventilation because of partial obstruction of the tracheal tube, and may thus be omitted in the most severely ill patients. It has not previously been possible to reduce the external diameter of the bronchoscope without reducing the diameter of the suction channel, thus reducing the suctioning capacity of the device. We believed that a better-designed bronchoscope could improve the safety of bronchoscopy in patients whose lungs were ventilated...
March 14, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28291908/does-gated-beam-delivery-impact-delivery-accuracy-on-an-elekta-linac
#18
Mohammed Jermoumi, Roger Xie, Daliang Cao, David J Housley, David M Shepard
In this study, we evaluated the performance of an Elekta linac in the delivery of gated radiotherapy. Delivery accuracy was examined with an emphasis on the impact of using short gating windows (low monitor unit beam-on segments) or long beam hold times. The performance was assessed using a 20cm by 20cm open field with the radiation delivered using a range of beam-on and beam-off time periods. Gated delivery measurements were also performed for two SBRT plans delivered using volumetric modulated arc therapy (VMAT)...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28290841/-novel-scale-for-long-term-prognostication-of-risk-of-death-and-nonfatal-cardiovascular-complications-in-patients-from-the-prognosis-ihd-registry
#19
S N Tolpygina, S Yu Martsevich, E A Gofman, A D Deev
PURPOSE: To elaborate a risk score for prognostication of long-term survival of patients with chronic ischemic heart disease (CIHD) using data of the PROGNOSIS-IHD Registry. MATERIAL AND METHODS: Participants of the PROGNOSIS-IHD Registry (n=641, 500 men, 141 women) were inhabitants of Moscow region consecutively admitted for planned hospitalization with diagnosis of IHD to the clinic of the Center of Preventive Medicine from 01.01.2004 to 31.12.2007. During hospitalization all patients underwent coronary angiography...
June 2016: Kardiologiia
https://www.readbyqxmd.com/read/28288302/whole-body-active-warm-up-and-inspiratory-muscle-warm-up-do-not-improve-running-performance-when-carrying-thoracic-loads
#20
Mark A Faghy, Peter Ian Brown
Whole body active warm ups (AWU) and inspiratory muscle warm up (IMW) prior to exercise improves performance on some endurance exercise tasks. This study investigated the effects of AWU with and without IMW upon 2.4 km running time-trial performance while carrying a 25 kg backpack, a common task and backpack load in physically demanding occupations. Participants (n = 9) performed five 2.4 km running time-trials with a 25 kg thoracic load preceded in random order by 1) IMW comprising 2 x 30 inspiratory efforts against a pressure-threshold load of 40 % maximal inspiratory pressure (PImax), 2) 10 min unloaded running (AWU) at lactate turnpoint (10...
March 13, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
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