Sebastian Larion, Caleb A Padgett, James D Mintz, Jennifer A Thompson, Joshua T Butcher, Eric J Belin de Chantemèle, Stephen Haigh, Sandeep Khurana, David J Fulton, David W Stepp
Background & Aims : Exercise as a lifestyle modification is frontline therapy for NAFLD, but how components of exercise attenuate steatosis is unclear. Approach & Results : To uncouple the effect of increased muscle mass from weight loss in obesity, Myostatin knockout mice were bred on a lean and obese db/db background. Myostatin deletion increases gastrocnemius mass, reduces hepatic steatosis and hepatic Srebp1 expression in obese mice, with no impact on adiposity or body weight. Interestingly, hypermuscularity reduces hepatic NADPH oxidase 1 ( Nox1 ) expression, but not Nox4 , in db/db mice...
January 23, 2024: American Journal of Physiology. Gastrointestinal and Liver Physiology