Oriana Nobus, Laurens Parmentier, Pieter Livens, Pieter Muyshondt, Krystyna Szewcyk, Christel Jacobs, Dorien Verdoodt, Leen Pieters, Quinten Thijssen, Bo Van Durme, Anne Vral, Joris Dirckx, Vincent Van Rompaey, Sandra Van Vlierberghe
Chronic suppurative otitis media (CSOM) is often associated with permanent tympanic membrane (TM) perforation and conductive hearing loss. The current clinical gold standard, using autografts and allografts, suffers from several drawbacks. Artificial replacement materials can help to overcome these drawbacks. Therefore, scaffolds fabricated through digital light processing (DLP) were herein created to support TM regeneration. Various UV-curable printing inks, including gelatin methacryloyl (GelMA), gelatin-norbornene-norbornene (GelNBNB) (crosslinked with thiolated gelatin (GelSH)) and alkene-functionalized poly-ε-caprolactone (E-PCL) (crosslinked with pentaerythritol tetrakis(3-mercaptopropionate) (PETA4SH)) were optimized regarding photo-initiator (PI) and photo-absorber (PA) concentrations through viscosity characterization, photo-rheology and the establishment of working curves for DLP...
March 11, 2024: Biomater Adv