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https://www.readbyqxmd.com/read/29921081/-efficacy-of-continuous-positive-airway-pressure-on-patients-with-refractory-otitis-media-with-effusion
#1
G H Zhao, W F Li, C Li, P P Shi, S Jiang, Y W He
No abstract text is available yet for this article.
June 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29916767/development-of-an-ear-cap-in-chronic-suppurative-otitis-media-using-additive-manufacturing-and-triz
#2
Mahesh B Mawale, Abhaykumar Kuthe, Anupama M Mawale, Sandeep W Dahake
The prevalence rate of chronic suppurative otitis media is high and its treatment continues to be a challenge for the otorhinolaryngologists. Due to middle ear infection, there may be pain, hearing loss and spontaneous rupture of the eardrum which results in perforation. Infections can cause a hole in the eardrum as a side effect of otitis media. The patients suffering from ear perforation or having a hole in eardrum require preventing entry of water in the ear. This article describes the development of ear cap using additive manufacturing and TRIZ (a collaborative tool) to prevent the entry of water in the ear during chronic otitis media...
June 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29915938/-state-of-the-art-of-quality-of-life-measurement-in-patients-with-chronic-otitis-media-and-conductive-hearing-loss
#3
REVIEW
S Lailach, I Baumann, T Zahnert, M Neudert
The evaluation of results after middle ear reconstruction has been mainly based on functional parameters. In clinical practice as well as in otological research, the pure tone audiogram represents the gold standard in the assessment of the postoperative outcome. In order to assess the patient's subjective outcome, outcome analyzes focus increasingly on the health-related quality of life (HRQOL). However, the evaluation of HRQOL requires reliable and validated measuring instruments. A modest number of validated questionnaires for determination of the disease-specific HRQOL in patients with chronic otitis media and/or conductive hearing loss are currently available...
June 18, 2018: HNO
https://www.readbyqxmd.com/read/29915563/immunological-profile-and-predisposition-to-autoimmunity-in-girls-with-turner-syndrome
#4
Aneta Monika Gawlik, Elzbieta Berdej-Szczot, Dorota Blat, Renata Klekotka, Tomasz Gawlik, Ewa Blaszczyk, Magdalena Hankus, Ewa Malecka-Tendera
Objective: The risk of autoimmune diseases (AD) in patients with Turner Syndrome (TS) is twice higher than in the general female population and four times higher than in the male population. The causes of the increased incidence of AD in TS are still under discussion. We hypothesized the presence of a specific humoral, cellular, and regulatory T cell (Treg) immunity profile which predisposes to AD, disorders of immunity, and disorders of immune regulation. Methods: The study encompassed 37 girls with TS and with no signs of infection...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29915406/characterization-of-mucoid-and-serous-middle-ear-effusions-from-patients-with-chronic-otitis-media-implication-of-different-biological-mechanisms
#5
Stéphanie Val, Marian Poley, Krueger Anna, Gustavo Nino, Kristy Brown, Marcos Pérez-Losada, Heather Gordish-Dressman, Diego Preciado
BACKGROUND: Chronic otitis media with effusion (COME) is characterized by persistent middle ear effusions that are in most cases highly viscous, but some patients present with serous fluid. This study aimed at comprehensively characterizing the macromolecular composition of mucoid vs. serous middle ear effusions (MEEs). METHODS: MEEs from patients with COME were analyzed for proteins by mass spectrometry (MS) and western blot techniques, total DNA quantity, bacterial DNA (16S sequencing), and cytokine content...
May 28, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29914826/a-pilot-study-to-investigate-the-therapeutic-effect-of-valsalva-maneuver-on-otitis-media-with-effusion-in-adults
#6
Jung Ju Han, Jung Mee Park, Dong Kee Kim, So Young Park, Shi Nae Park
OBJECTIVE: This pilot study was performed to investigate the therapeutic effect of Valsalva maneuver on otitis media in adults and to evaluate the prognostic factors for the good response. METHODS: Thirty nine ears of 32 adult patients who were diagnosed as otitis media with effusion and managed by one-week Valsalva maneuver (>20/day) without any other medication were included in this study. Its therapeutic efficacy was evaluated and the prognostic factors which predict the response of Valsalva maneuver were analyzed by comparing various clinical and audiological factors between success and failure groups...
June 15, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29914542/acute-mastoiditis-in-an-italian-pediatric-tertiary-medical-center-a-15-year-retrospective-study
#7
Claudia Balsamo, Carlotta Biagi, Margherita Mancini, Ilaria Corsini, Rosalba Bergamaschi, Marcello Lanari
BACKGROUND: Acute mastoiditis is the main suppurative complication of acute otitis media. Its incidence ranges from 1.2 to 4.2/100.000 children/year and a rise has been reported in the last years. There are controversial data regarding risk factors for mastoiditis and its complications. AIM OF THE STUDY: to evaluate demographics and clinical characteristics of children with acute mastoiditis and to identify possible risk factors for complications. METHODS: We retrospectively reviewed medical charts of all the children aged 1 month-14 years admitted to our Paediatric Emergency Department from January 2002 to December 2016...
June 18, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29912830/intracochlear-pressures-in-simulated-otitis-media-with-effusion-a-temporal-bone-study
#8
Mohamed A Alhussaini, Renee M Banakis Hartl, Victor Benichoux, Daniel J Tollin, Herman A Jenkins, Nathaniel T Greene
HYPOTHESIS: Simulated otitis media with effusion reduces intracochlear pressures comparable to umbo velocity. BACKGROUND: Otitis media with effusion is a common cause of temporary hearing loss, particularly in children, producing deficits of 30 to 40 dB. Previous studies measured the effects of simulated effusion on ossicular mechanics; however, no studies have measured cochlear stimulation directly. Here, we compare pressures in the scala vestibuli and tympani to umbo velocity, before and after induction of simulated effusion in cadaveric human specimens...
June 15, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29912823/individualized-learning-plan-ilp-is-an-effective-tool-in-assessing-achievement-of-otology-related-subcompetency-milestones
#9
Maja Svrakic, John P Bent
OBJECTIVE: To investigate the individualized learning plan (ILP) as a tool in assessment of residents' milestone achievements as they pertain to Otology subcompetencies: Chronic Ear Disease, Pediatric Otitis Media, and Hearing Loss. STUDY DESIGN: Prospective study. METHODS: Twenty otolaryngology residents were instructed to use an ILP and identify six milestones from three otology-related subcompetencies to focus on during the course of a 3-month rotation...
June 15, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29909018/successful-treatment-of-eosinophilic-otitis-media-associated-with-severe-bronchial-asthma-with-an-anti-il-5-monoclonal-antibody-mepolizumab
#10
Isao Suzaki, Yurika Kimura, Akihiko Tanaka, Kojiro Hirano, Atsushi Ishibashi, Tomomi Mizuyoshi, Izumi Ando, Tatsuya Kitajima, So Watanabe, Yasuyuki Hinonira, Hitome Kobayashi
Eosinophilic otitis media (EOM), which is characterized by the accumulation of eosinophils in middle ear effusion and the middle ear mucosa, is a refractory type of otitis media that is often associated with asthma. Although an early diagnosis and appropriate treatment are necessary to prevent the progression of hearing loss in patients with EOM, there are currently no well-established treatments for this condition. We treated a 60-year-old male patient with asthma and EOM. The patient's asthma was poorly controlled, despite the use of high-dose inhaled corticosteroids, long-acting beta-agonist treatment, and the regular use of systemic corticosteroids...
June 13, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29908315/expression-and-purification-of-pneumococcal-surface-protein-a-of-clade-4-in-escherichia-coli-using-hydroxylapatite-and-ion-exchange-column-chromatography
#11
Hualong Xi, Jinfei Yu, Qing Sun, Jingcai Lu, Tiejun Gu, Xiaonan Guo, Bo Li, Xiaorui Chen, Kaixin Zhang, Wei Kong, Yongge Wu
Streptococcus pneumoniae is a major pathogen that causes life-threatening diseases, such as pneumonia, otitis media, bacteremia, and meningitis, worldwide and especially in young children and the elderly. Pneumococcal surface protein A (PspA) is a widely studied candidate protein vaccine that represents a promising replacement for current polysaccharide and polysaccharide-conjugate vaccines. In this study, we describe a simple method to produce PspA of clade 4 from an Escherichia coli expression system using hydroxylapatite and ion-exchange chromatography...
June 13, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29906263/maternal-peripartum-serum-ddt-e-and-urinary-pyrethroid-metabolite-concentrations-and-child-infections-at-2-years-in-the-vhembe-birth-cohort
#12
Jonathan Huang, Brenda Eskenazi, Riana Bornman, Stephen Rauch, Jonathan Chevrier
BACKGROUND: Indoor residual spraying (IRS) of insecticides, conducted in low- and middle-income countries to control malaria, may result in high exposure to dichlorodiphenyltrichloroethane (DDT), its breakdown product dichlorodiphenyldichloroethylene (DDE), or pyrethroids. Animal studies suggest in utero exposure to these chemicals may increase childhood infection frequency. OBJECTIVES: We investigated associations between maternal DDT/E and pyrethroid metabolite concentration and child infection associations in an IRS setting in which susceptibility factors are common and infections are leading causes of child morbidity and mortality...
June 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29899987/-streptococcus-pyogenes-and-invasive-central-nervous-system-infection
#13
Ekamjeet Randhawa, John Woytanowski, Kedesha Sibliss, Ian Sheffer
Streptococcus pyogenes is a Gram-positive beta-hemolytic bacteria, also known as group A streptococci, that causes a range of infections. The most common presentation is acute pharyngitis; however, it is also implicated in skin and soft tissue infections, and less commonly bacteremia, osteomyelitis, pneumonia, otitis media and sinusitis. Group A streptococci infections of the central nervous system are exceedingly rare in the antibiotic era. The mechanism of infection is typically contiguous spread from existing infection or via direct inoculation...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29894453/gradenigo-syndrome-induced-by-suppurative-otitis-media
#14
Nazim Bozan, Ufuk Düzenli, Abdulzaziz Yalinkilic, Abdurrahman Ayral, Mehmet Parlak, Mahfuz Turan, Ahmet Faruk Kiroglu
Gradenigo syndrome was defined as a clinical triad of otitis media, severe orbito-facial pain, and ipsilateral sixth cranial nerve palsy. It may occur as a complication of either acute or chronic otitis media. Herein, we will report a case of Gradenigo syndrome induced by suppurative chronic otitis media that was promptly diagnosed and aggressively treated.
June 11, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29890817/nonshaved-ear-surgery-effect-of-hair-on-surgical-site-infection-of-the-middle-ear-mastoid-surgery-and-patients-preference-for-the-hair-removal
#15
Dong-Hee Lee, Soonil Yoo, Eunhye Shin, Yesun Cho
Background and Objectives: This study aimed 1) to compare the rates of surgical site infection (SSI) between two groups with and without preoperative hair shaving, 2) to compare the bacterial colonization just before the skin incision between them, and 3) to evaluate people's preference for the hair shaving. Subjects and Methods: The retrospective study enrolled cases in which middle ear and mastoid surgery was performed with as well as without hair removal. Main measurement outcomes were the SSI rate within 3 months following the surgery, bacterial culture results obtained from the incision area just before the skin incision, and questionnaire to evaluate the preference for hair shaving from patients with chronic suppurative otitis media but without experience with the ear surgery...
June 14, 2018: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29888693/the-anti-inflammatory-effects-of-erythromycin-clarithromycin-azithromycin-and-roxithromycin-on-histamine-induced-otitis-media-with-effusion-in-guinea-pigs
#16
B Ersoy, B Aktan, K Kilic, M S Sakat, S Sipal
BACKGROUND: Otitis media with effusion is a clinical manifestation characterised by inflammation of middle-ear mucosa. This study investigated the therapeutic effect of erythromycin, clarithromycin, azithromycin and roxithromycin on a histamine-induced animal model of otitis media with effusion. METHODS: The animals were divided into five groups, receiving erythromycin, clarithromycin, azithromycin, roxithromycin or saline solution. The guinea pigs in the study groups received erythromycin (40 mg/kg/day), clarithromycin (15 mg/kg/day), azithromycin (10 mg/kg/day) or roxithromycin (10 mg/kg/day) for 3 days by gastric tube...
June 11, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29885746/the-treatment-outcomes-of-rituximab-for-intractable-otitis-media-with-anca-associated-vasculitis
#17
Masahiro Okada, Koichiro Suemori, Daiki Takagi, Masato Teraoka, Hiroyuki Yamada, Jun Ishizaki, Takuya Matsumoto, Hitoshi Hasegawa, Naohito Hato
OBJECTIVE: To investigate treatment outcomes, hearing outcomes, and adverse effects of rituximab (RTX) for intractable otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV). METHODS: Twenty-three patients who met the criteria proposed by the OMAAV study group were included. RTX was used for patients who had difficulty achieving induction of remission using glucocorticoids (GC) and intravenous cyclophosphamide (IVCY). RESULTS: Six patients were treated with RTX (RTX group), while 17 patients did not require RTX for induction of remission (non-RTX group)...
June 6, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29885657/infectious-disease-burden-and-antibiotic-prescribing-in-primary-care-in-israel
#18
Marcelo Low, Ronit Almog, Ran D Balicer, Nicky Liberman, Raul Raz, Avi Peretz, Orna Nitzan
BACKGROUND: Antibiotics are frequently prescribed at many of the visits to primary care clinics, often for conditions for which they provide no benefit, including viral respiratory tract infections. OBJECTIVES: The aim was to evaluate primary care visits due to infectious diseases, and to estimate antibiotic prescribing and antibiotic dispensing by pharmacies. METHODS: Diagnosis of infectious disease, antibiotic prescribing and dispensing data at the individual patient level were extracted for 2015 from Clalit Health Services' electronic medical records and linked to determine the condition for which the antimicrobial was prescribed...
June 9, 2018: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/29884809/in-vivo-detection-of-nanometer-scale-structural-changes-of-the-human-tympanic-membrane-in-otitis-media
#19
Roshan Dsouza, Jungeun Won, Guillermo L Monroy, Malcolm C Hill, Ryan G Porter, Michael A Novak, Stephen A Boppart
Otitis media (OM) is a common ear infection and a leading cause of conductive hearing loss in the pediatric population. Current technologies such as otoscopy, pneumatic otoscopy, tympanometry, and acoustic reflectometry are used to diagnose OM, which can reasonably diagnose the infection with a sensitivity and specificity of 50-90% and 60-90%, respectively. However, these techniques provide limited information about the physical architecture of the tympanic membrane (TM), or what may lie behind it. Here, we report the detection of nanometer-scale structural changes of the TM using nano-sensitive optical coherence tomography (nsOCT)...
June 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29884749/adenotonsillar-microbiome-an-update
#20
REVIEW
James Jordan Johnston, Richard Douglas
Pathogenic bacteria associated with the adenoids and tonsils cause much morbidity in the paediatric population. Hyperplasia of the adenoids is associated with otitis media with effusion and hyperplasia of the palatine tonsils is associated with both recurrent tonsillitis and obstructive sleep apnoea. Most current knowledge of the microbiology of the upper airways has been derived from culture-based studies, which usually reflect only a small fraction of the bacteria present on the mucosal surface. Culture-independent molecular surveys based on 16S ribosomal RNA sequencing are now being employed to determine the microbiota on the surface and within the tissue of adenoids and palatine tonsils...
June 8, 2018: Postgraduate Medical Journal
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