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Otitis media

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https://www.readbyqxmd.com/read/28319172/correction-identification-of-potential-novel-biomarkers-and-signaling-pathways-related-to-otitis-media-induced-by-diesel-exhaust-particles-using-transcriptomic-analysis-in-an-in-vivo-system
#1
Hyo Jeong Kim, So Young Kim, Jee Young Kwon, Yeo Jin Kim, Seung Hun Kang, Won-Hee Jang, Jun Ho Lee, Myung-Whan Suh, Jae-Jun Song, Young Rok Seo, Moo Kyun Park
[This corrects the article DOI: 10.1371/journal.pone.0166044.].
2017: PloS One
https://www.readbyqxmd.com/read/28303055/inner-ear-disturbances-related-to-middle-ear-inflammation
#2
REVIEW
Michihiko Sone
The inner and middle ear are connected mainly through round and oval windows, and inflammation in the middle ear cavity can spread into the inner ear, which might induce a disturbance. In cases with intractable otitis media, attention should also be paid to symptoms related to the inner ear. In this paper, middle ear inflammation and related inner ear disturbances are reviewed with a focus on representative middle ear diseases (such as acute otitis media, chronic otitis media, otitis media with anti-neutrophil cytoplasmic antibody-associated vasculitis, eosinophilic otitis media, cholesteatoma with labyrinthine fistula, and reflux-related otitis media)...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28298481/categorization-of-national-pediatric-quality-measures
#3
Samantha A House, Eric R Coon, Alan R Schroeder, Shawn L Ralston
BACKGROUND AND OBJECTIVE: The number of quality measures has grown dramatically in recent years. This growth has outpaced research characterizing content and impact of these metrics. Our study aimed to identify and classify nationally promoted quality metrics applicable to children, both by type and by content, and to analyze the representation of common pediatric issues among available measures. METHODS: We identified nationally applicable quality measure collections from organizational databases or clearinghouses, federal Web sites, and key informant interviews and then screened each measure for pediatric applicability...
March 15, 2017: Pediatrics
https://www.readbyqxmd.com/read/28294083/tensor-veli-palatini-electromyography-for-monitoring-eustachian-tube-rehabilitation-in-otitis-media
#4
P M Picciotti, G Della Marca, L D'Alatri, D Lucidi, M Rigante, E Scarano
BACKGROUND: The pathogenesis of otitis media is related to Eustachian tube dysfunction. The tensor veli palatini muscle actively opens the Eustachian tube and promotes middle-ear ventilation. This study describes a technique for paratubal electromyography that uses a surface, non-invasive electrode able to record tensor veli palatini muscle activity during swallowing. METHODS: Twenty otitis media patients and 10 healthy patients underwent tensor veli palatini electromyography...
March 15, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28294080/outcome-and-cost-analysis-of-bilateral-sequential-same-day-cartilage-tympanoplasty-compared-with-bilateral-staged-tympanoplasty
#5
A D Olusesi, O Oyeniran
BACKGROUND: Few studies have compared bilateral same-day with staged tympanoplasty using cartilage graft materials. METHODS: A prospective randomised observational study was performed of 38 chronic suppurative otitis media patients (76 ears) who were assigned to undergo bilateral sequential same-day tympanoplasty (18 patients, 36 ears) or bilateral sequential tympanoplasty performed 3 months apart (20 patients, 40 ears). Disease duration, intra-operative findings, combined duration of surgery, post-operative graft appearance at 6 weeks, post-operative complications, re-do rate and relative cost of surgery were recorded...
March 15, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28290230/cilia-and-ear
#6
Gioia Piatti, Maria Margherita De Santi, Sara Torretta, Lorenzo Pignataro, Daniela Soi, Umberto Ambrosetti
OBJECTIVE: To investigate the prevalence of otological complications derived from primary ciliary dyskinesia (PCD) in adulthood. METHODS: Twenty-three patients with diagnosed PCD underwent medical history aimed at recording the presence of ear, nose, and throat manifestations (ENT) and any surgical treatments. The ENT objectivity was annotated, and then patients were subjected to audiometric test, tympanometry, registration of otoacoustic emission, and vestibular evaluation...
April 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28289114/parents-expectations-and-experiences-of-antibiotics-for-acute-respiratory-infections-in-primary-care
#7
Peter D Coxeter, Chris Del Mar, Tammy C Hoffmann
PURPOSE: Primary care visits for children with acute respiratory infections frequently result in antibiotic prescriptions, although antibiotics have limited benefits for common acute respiratory infections and can cause harms, including antibiotic resistance. Parental demands are often blamed for antibiotic prescription. We aimed to explore parents' beliefs about antibiotic necessity, quantify their expectations of antibiotic benefit, and report experiences of other management options and exposure to and preferences for shared decision making...
March 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28288168/a-novel-flow-cytometry-based-assay-for-the-quantification-of-antibody-dependent-pneumococcal-agglutination
#8
Marrit N Habets, Saskia van Selm, Christa E van der Gaast-de Jongh, Dimitri A Diavatopoulos, Marien I de Jonge
The respiratory pathogen Streptococcus pneumoniae is a major cause of diseases such as otitis media, pneumonia, sepsis and meningitis. The first step towards infection is colonization of the nasopharynx. Recently, it was shown that agglutinating antibodies play an important role in the prevention of mucosal colonization with S. pneumoniae. Here, we present a novel method to quantify antibody-dependent pneumococcal agglutination in a high-throughput manner using flow cytometry. We found that the concentration of agglutinating antibodies against pneumococcal capsule are directly correlated with changes in the size and complexity of bacterial aggregates, as measured by flow cytometry and confirmed by light microscopy...
2017: PloS One
https://www.readbyqxmd.com/read/28286870/d-amino-acids-do-not-inhibit-pseudomonas-aeruginosa-biofilm-formation
#9
Wee Tin K Kao, Mitchell Frye, Patricia Gagnon, Joseph P Vogel, Richard Chole
OBJECTIVE: Pseudomonas aeruginosa, a known biofilm-forming organism, is an opportunistic pathogen that plays an important role in chronic otitis media, tracheitis, cholesteatoma, chronic wounds, and implant infections. Eradication of biofilm infections has been a challenge because the biofilm phenotype provides bacteria with a protective environment from the immune system and antibiotics; thus, there has been great interest in adjunctive molecules that may inhibit biofilm formation or cause biofilm dispersal...
February 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28283791/balloon-eustachian-tuboplasty-in-children
#10
A Leichtle, D Hollfelder, B Wollenberg, K-L Bruchhage
Endonasal ballon dilatation of the Eustachian tube (BET) is a promising treatment for Eustachian tube dysfunction with encouraging results over the last years in adults. In addition, in children, single studies demonstrated promising results, but revealed the necessity for broader and additional studies. Our retrospective analysis presents outcomes with BET in children with chronic obstructive dysfunction of the Eustachian tube, showing resistance to the conventional therapy after adenotomy with paracentesis or grommets (ventilation tubes)...
March 10, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28279802/prevention-of-influenza-virus-induced-bacterial-superinfection-by-standardized-echinacea-purpurea-via-regulation-of-surface-receptor-expression-in-human-bronchial-epithelial-cells
#11
Vimalanathan Selvarani, Schoop Roland, Suter Andy, Hudson James
Viral infections may predispose the airways to secondary bacterial infections that can lead to unfavorable progression of principally self-limiting illnesses. Such complicated respiratory infections include pneumonia, bronchitis, sinusitis, acute otitis media, and sepsis, which cause high morbidity and lethality. Some of the pathogenic consequences of viral infections, like the expression of bacterial adhesion receptors and the disturbance of physical barrier integrity due to inflammation, may create permissive conditions for co-infections...
March 6, 2017: Virus Research
https://www.readbyqxmd.com/read/28279741/enhanced-non-invasive-trans-tympanic-delivery-of-ciprofloxacin-through-encapsulation-into-nano-spanlastic-vesicles-fabrication-in-vitro-characterization-and-comparative-ex-vivo-permeation-studies
#12
Abdulaziz Mohsen Al-Mahallawi, Omneya Mohammed Khowessah, Raguia Ali Shoukri
The aim of this research was to encapsulate ciprofloxacin, a broad spectrum fluoroquinolone antibiotic, into Span 60 based nano-elastic vesicles, nano-spanlastics, for accomplishing improved non invasive trans-tympanic delivery, providing means for ototopical treatment of acute otitis media (AOM). To achieve this purpose, ciprofloxacin-loaded nano-spanlastics were prepared by thin film hydration (TFH) technique, using several non-ionic edge activators (EAs) according to full factorial design (3(2)). The investigation of the effect of formulation variables on nano-spanlastic characteristics and selection of the optimum formula were performed using Design-Expert(®) software...
March 7, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28279564/pneumococcal-carriage-and-serotype-variation-before-and-after-introduction-of-pneumococcal-conjugate-vaccines-in-patients-with-acute-otitis-media-in-switzerland
#13
Aurélie Allemann, Pascal M Frey, Silvio D Brugger, Markus Hilty
BACKGROUND: Acute otitis media (AOM) is an important cause for antibiotic prescription within the paediatric population and Streptococcus pneumoniae is a major pathogen associated with AOM episodes. This study aimed at analysing the influence of the heptavalent and 13-valent pneumococcal conjugate vaccines (PCV7 and PCV13) on pneumococcal carriage and serotype distribution in AOM. METHODS: Nasopharyngeal swabs (NPS) and middle ear fluid (MEF) were collected within a Swiss surveillance study of outpatients from all ages with AOM between 2004 and 2015, covering three vaccination eras (pre-PCV7, PCV7 and PCV13)...
March 6, 2017: Vaccine
https://www.readbyqxmd.com/read/28277483/endoscopy-assisted-ear-surgery-for-treatment-of-chronic-otitis-media-with-cholesteatoma-adhesion-or-retraction-pockets
#14
Cagatay Han Ulku
The objective of this study was to analyze the results of endoscopy-assisted ear surgery for the treatment of chronic otitis media with cholesteatoma, adhesion, or retraction pockets.Fifty-one patients who underwent oto-endoscopy-assisted canal wall up tympanomastoid surgery and/or limited anterior atticotomy with tympanoplasty for chronic otitis media with cholesteatoma, adhesion, or retraction pocket from 2006 to 2013 have been included in this study. Eradication of the disease from the middle ear and mastoid air cells was achieved by combination of the oto-microscobic and oto-endoscopic approaches...
March 8, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28277413/community-primary-care-provider-preferences-for-emergency-department-follow-up-recommendations-a-regional-study
#15
Marissa A Hendrickson, Eta Obeya, Andrew R Wey, Philippe R Gaillard
BACKGROUND: Children who present to emergency departments (EDs) for care are frequently advised to follow up with their primary care providers (PCPs) after discharge; little is known about whether PCPs agree that follow-up advised by EDs is appropriate for their patients. OBJECTIVES: The aims of this study were to determine PCP preferences for follow-up recommendations given to their pediatric patients at the time of ED visits and to compare these preferences to reported emergency medicine provider (EMP) practice...
March 9, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28277045/antibiotic-prescribing-in-relation-to-diagnoses-and-consultation-rates-in-belgium-the-netherlands-and-sweden-use-of-european-quality-indicators
#16
Mia Tyrstrup, Alike van der Velden, Sven Engstrom, Geert Goderis, Sigvard Molstad, Theo Verheij, Samuel Coenen, Niels Adriaenssens
OBJECTIVE: To assess the quality of antibiotic prescribing in primary care in Belgium, the Netherlands and Sweden using European disease-specific antibiotic prescribing quality indicators (APQI) and taking into account the threshold to consult and national guidelines. DESIGN: A retrospective observational database study. SETTING: Routine primary health care registration networks in Belgium, the Netherlands and Sweden. SUBJECTS: All consultations for one of seven acute infections [upper respiratory tract infection (URTI), sinusitis, tonsillitis, otitis media, bronchitis, pneumonia and cystitis] and the antibiotic prescriptions in 2012 corresponding to these diagnoses...
March 3, 2017: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/28262542/role-of-preoperative-air-bone-gap-in-tinnitus-outcome-after-tympanoplasty-for-chronic-otitis-media-with-tinnitus
#17
Hong Chan Kim, Chul Ho Jang, Young Yoon Kim, Jong Yuap Seong, Sung Hoon Kang, Yong Beom Cho
INTRODUCTION: Previous reports indicated that middle ear surgery might partially improve tinnitus after surgery. However, until now, no influencing factor has been determined for tinnitus outcome after middle ear surgery. OBJECTIVE: The purpose of this study was to investigate the association between preoperative air-bone gap (ABG) and tinnitus outcome after tympanoplasty type I. METHODS: Seventy-five patients with tinnitus who had more than 6 months of symptoms of Chronic Otitis Media (COM) on the ipsilateral side that were refractory to medical treatment were included in this study...
February 14, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28261574/persistent-and-recurrent-bacterial-bronchitis-a-paradigm-shift-in-our-understanding-of-chronic-respiratory-disease
#18
REVIEW
Alya Ishak, Mark L Everard
The recent recognition that the conducting airways are not "sterile" and that they have their own dynamic microbiome, together with the rapid advances in our understanding of microbial biofilms and their roles in the causation of respiratory diseases (such as chronic bronchitis, sinusitis, and chronic otitis media), permit us to update the "vicious circle" hypothesis of the causation of bronchiectasis. This proposes that chronic inflammation driven by persistent bacterial bronchitis (PBB) causes damage to both the epithelium, resulting in impaired mucociliary clearance, and to the airway wall, which eventually manifests as bronchiectasis...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28258074/cost-effectiveness-of-watchful-waiting-in-acute-otitis-media
#19
Di Sun, T J McCarthy, Danica B Liberman
BACKGROUND: American Academy of Pediatrics guidelines for acute otitis media (AOM) allow for children meeting certain criteria to undergo watchful waiting (WW). The cost-effectiveness of this policy has not been evaluated in the United States. METHODS: A retrospective review of a random selection of 250 patients ≤18 years old with AOM in the emergency department of a tertiary care children's hospital was used to characterize current practice of AOM management...
March 3, 2017: Pediatrics
https://www.readbyqxmd.com/read/28257541/risk-factors-for-outpatient-use-of-antibiotics-in-children-with-acute-respiratory-illnesses
#20
Sophie R Zhao, Marie R Griffin, Barron L Patterson, Rachel L Mace, Dayna Wyatt, Yuwei Zhu, H Keipp Talbot
OBJECTIVES: Antibiotics for acute respiratory illness (ARI) constitute most pediatric medication use and contribute to the emergence of antimicrobial resistance. We investigated antibiotic prescription risk factors for ARI in pediatric clinics and clinical follow-up in individuals prescribed and not prescribed antibiotics. METHODS: In this observational study, we enrolled children ages 2 to 17 years old presenting with ARI with fever to two academic pediatric primary care outpatient clinics during influenza season 2013-2014...
March 2017: Southern Medical Journal
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