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https://www.readbyqxmd.com/read/29232053/differential-diagnosis-of-otitis-media-with-effusion-using-label-free-raman-spectroscopy-a-pilot-study
#1
Rishikesh Pandey, Chi Zhang, Jeon Woong Kang, Parind M Desai, Ramachandra Rao Dasari, Ishan Barman, Tulio A Valdez
Otitis media with effusion (OME) is an important and common condition affecting hearing in pediatric patients characterized by the presence of fluid in the middle ear space. The fluid is normally described as serous or mucoid based on differences in the fluid viscosity. The differential diagnosis of two OMEs namely serous and mucoid is of significant clinical value because while the former is self-limiting, surgical procedure is commonly required for the latter. However, accurate identification of fluid types remains a challenging target unattainable with current clinical modalities due to unavailability of non-perturbative molecular tools...
December 12, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29231979/otitis-media-with-effusion-in-the-boxer-a-report-of-seven-cases
#2
S Paterson
The aim of this study was to describe otitis media with effusion in seven boxers. All dogs presented with a range of clinical signs, which included head shaking, neurological dysfunction, pain on opening of the mouth and reduction in hearing ability. Otitis media was confirmed under general anaesthesia in each case by video-otoscopic identification of a bulging pars tensa and subsequent myringotomy, which revealed a tenacious mucus plug within the middle ear. Brainstem auditory evoked response thresholds were elevated in all affected ears...
December 12, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29230970/the-dnabii-family-of-proteins-is-comprised-of-the-only-nucleoid-associated-proteins-required-for-nontypeable-haemophilus-influenzae-biofilm-structure
#3
Aishwarya Devaraj, John Buzzo, Christopher J Rocco, Lauren O Bakaletz, Steven D Goodman
Biofilms play a central role in the pathobiology of otitis media (OM), bronchitis, sinusitis, conjunctivitis, and pneumonia caused by nontypeable Haemophilus influenzae (NTHI). Our previous studies show that extracellular DNA (eDNA) and DNABII proteins are essential components of biofilms formed by NTHI. The DNABII protein family includes integration host factor (IHF) and the histone-like protein HU and plays a central role in NTHI biofilm structural integrity. We demonstrated that immunological targeting of these proteins during NTHI-induced experimental OM in a chinchilla model caused rapid clearance of biofilms from the middle ear...
December 12, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/29227464/antibiotic-resistance-of-potential-otopathogens-isolated-from-nasopharyngeal-flora-of-children-with-acute-otitis-media-before-during-and-after-pneumococcal-conjugate-vaccines-implementation
#4
Alexis Rybak, Corinne Levy, Stéphane Bonacorsi, Stéphane Béchet, François Vié le Sage, Annie Elbez, Emmanuelle Varon, Robert Cohen
BACKGROUNDL: To re-evaluate antibiotic strategies for acute otitis media (AOM) in young children, we analyzed the trends of nasopharyngeal carriage and antibiotic resistance of Streptococcus pneumoniae (Sp), Haemophilus influenzae (Hi) and Moraxella catarrhalis (Mc) isolated from young children with AOM during a 16-year period. METHODS: This cross-sectional study analyzed from 2001 to 2016, the nasopharyngeal carriage of Sp, Hi and Mc of young children with AOM...
December 8, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29227448/cochlear-implantation-in-chronic-otitis-media-with-cholesteatoma-and-open-cavities-long-term-surgical-outcomes
#5
Ashish Vashishth, Andrea Fulcheri, Sampath Chandra Prasad, Manjunath Dandinarasaiah, Antonio Caruso, Mario Sanna
OBJECTIVES: To evaluate the long-term surgical outcomes of cochlear implantation (CI) in chronic otitis media (COM) with cholesteatoma and open cavities using subtotal petrosectomy (STP). To review device explantation (DE) patients and reimplantation considerations. STUDY DESIGN: Retrospective review. SETTING: Otology and skull base center. PATIENTS AND METHODS: Charts of 35 patients (36 ears) with COM with cholesteatoma, including open cavities, who underwent CI were reviewed for surgical outcomes and DE...
January 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29225513/an-abrupt-bleeding-of-the-anteriorly-displaced-sigmoid-sinus-a-rare-complication-of-myringoplasty
#6
Sarah Zaher Addeen, Mohammad Al-Mohammad
Background: The location of the sigmoid sinus within the mastoid cavity is quite variable. An anteriorly- displaced vertical segment of the sigmoid sinus constitutes an uncommon but dangerous anatomical variation that surgeons rarely encounter during surgery. In this variation, the sigmoid sinus lays underneath a very thin bony flap, which makes it easily damaged. Thus, an abrupt fatal bleeding might occur. Despite the many hypotheses about its origin (Chronic otitis media, hypopneumatization, etc...
2017: BMC Ear, Nose, and Throat Disorders
https://www.readbyqxmd.com/read/29224773/parental-knowledge-and-attitudes-to-childhood-hearing-loss-and-hearing-services-in-the-solomon-islands
#7
Annette Kaspar, Obiga Newton, Joseph Kei, Carlie Driscoll, De Wet Swanepoel, Helen Goulios
OBJECTIVE: An understanding of parental knowledge and attitudes towards childhood hearing loss is essential to the successful implementation of audiology services. The present study aimed to investigate parental knowledge and attitudes among parents in the Solomon Islands. METHODS AND MATERIALS: A total of 100 mothers and 50 fathers were administered a questionnaire via semi-structured interviews. RESULTS: Highest parental awareness of aetiology of childhood hearing loss was noted for otitis media (94%), noise exposure (87...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29224765/pre-and-post-operative-application-of-acoustic-rhinometry-in-children-with-otitis-media-with-effusion-and-with-or-without-adenoid-hypertrophy-a-retrospective-analysis
#8
Dan Lai, Gang Qin, Junmei Pu, Lu Liu, Yiying Yang
BACKGROUND: There is no standardized scheme for preoperative evaluation of adenoid hypertrophy or a consensus on surgical indications for adenoidectomy in children with otitis media with effusion (OME), especially for young children intolerant to nasal endoscopic assessment. The aim of this study was to evaluate the efficacy and reliability of acoustic rhinometry (AR) in evaluating benefits from adenoidectomy in children with OME. METHOD: Children with OME who were scheduled for surgical intervention were reviewed and AR tests performed preoperatively and postoperatively...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29224762/outcomes-of-tympanoplasty-in-children-with-down-syndrome
#9
Saied Ghadersohi, Jonathan B Ida, Bharat Bhushan, Kathleen R Billings
INTRODUCTION: The prevalence of chronic otitis media with effusion (COME), and Eustachian tube dysfunction (ETD) is high in Down syndrome (DS) patients. This often necessitates multiple tympanostomy tube (TT) placements resulting in a higher rate of persistent tympanic membrane (TM) perforation requiring tympanoplasty for repair. OBJECTIVES: To assess risk factors for persistent perforation and outcomes of tympanoplasty in DS patients. METHODS: Retrospective case series of 91 ears in 69 DS patients with TM perforations, who were either observed or underwent tympanoplasty...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29224752/incidence-and-factors-associated-with-revision-adenoidectomy-a-retrospective-study
#10
James Johnston, Murali Mahadevan, Richard G Douglas
INTRODUCTION: Adenoidectomy is one of the most commonly performed pediatric operations worldwide. There are a proportion of children who require revision adenoidectomy. Yet there is little in the literature about the incidence, associated factors and etiology of adenoidal regrowth. The aim of this retrospective cohort study was to determine incidence and factors associated with revision adenoidectomy. METHODS: An extraction of all hospital morbidity records belonging to patients under the age of 18 years who underwent one or more adenoidectomy procedures (with or without tonsillectomy) between January 1, 2000 and June 2016 at a tertiary care children's hospital was performed...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29223643/povidone-iodine-soaked-gelfoam-for-the-treatment-of-recalcitrant-otomycosis%C3%A2-%C3%A2-our-experiences-at-a-tertiary-care-teaching-hospital-of-eastern-india
#11
S K Swain, I C Behera, M C Sahu, A Das
INTRODUCTION: Otomycosis is a common clinical condition seen in outpatient department of otorhinolaryngology. The treatment of the otomycosis is also very simple. However, sometime it is difficult to treat otomycosis along with mastoid cavity, chronic suppurative otitis media, immunocompromised patient, etc. with conventional treatment, called recalcitrant otomycosis. Here, we describe a technique of treatment for recalcitrant otomycosis. MATERIALS AND METHODS: This is a prospective observational study/clinical trial carried out on 44 patients of recalcitrant otomycosis...
December 6, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29217752/mapping-the-distribution-of-stem-progenitor-cells-across-the-middle-ear-during-homeostasis-and-inflammation
#12
Abigail S Tucker, Carlene J Dyer, Juan M Fons Romero, Tathyane H N Teshima, Jennifer C Fuchs, Hannah Thompson
The middle ear epithelium is derived from neural crest and endoderm, which line distinct regions of the middle ear cavity. Here we investigate the distribution of putative stem cell markers in the middle ear combined with an analysis of the location of label retaining cells (LRCs) to create a map of the middle ear mucosa. We show that proliferating cells and LRCs were associated with specific regions of the ear epithelium, concentrated in the hypotympanum at the base of the auditory bulla and around the ear drum...
December 7, 2017: Development
https://www.readbyqxmd.com/read/29217599/ers-statement-on-obstructive-sleep-disordered-breathing-in-1-to-23-month-old-children
#13
Athanasios G Kaditis, Maria Luz Alonso Alvarez, An Boudewyns, Francois Abel, Emmanouel I Alexopoulos, Refika Ersu, Koen Joosten, Helena Larramona, Silvia Miano, Indra Narang, Hui-Leng Tan, Ha Trang, Marina Tsaoussoglou, Nele Vandenbussche, Maria Pia Villa, Dick Van Waardenburg, Silke Weber, Stijn Verhulst
The present statement was produced by a European Respiratory Society Task Force to summarise the evidence and current practice on the diagnosis and management of obstructive sleep disordered breathing (SDB) in children aged 1-23 months. A systematic literature search was completed and 159 articles were summarised to answer clinically relevant questions. SDB is suspected when symptoms or abnormalities related to upper airway obstruction are identified. Morbidity (pulmonary hypertension, growth delay, behavioural problems) and coexisting conditions (feeding difficulties, recurrent otitis media) may be present...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29203943/severe-upper-airway-obstruction-following-bilateral-ventral-bulla-osteotomy-in-a-cat
#14
Chiara De Gennaro, Enzo Vettorato, Federico Corletto
A cat that underwent bilateral ventral bulla osteotomy (VBO) for treatment of otitis media and otitis interna secondary to bilateral inflammatory polyps, developed upper airway obstruction (UAO) soon after tracheal extubation. The cat was re-intubated but the UAO did not resolve at the next extubation. Eventually, tracheostomy was performed. Upper airway obstruction is a potential postoperative complication of bilateral VBO in cats.
December 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/29203544/mapping-protective-regions-on-a-three-dimensional-model-of-the-moraxella-catarrhalis-vaccine-antigen-oligopeptide-permease-a
#15
Antonia C Perez, Antoinette Johnson, Ziqiang Chen, Gregory E Wilding, Michael G Malkowski, Timothy F Murphy
A vaccine against Moraxella catarrhalis will reduce tremendous morbidity, mortality, and financial burden by preventing otitis media in children and exacerbations of COPD in adults. Oligopeptide permease A (OppA) is a candidate vaccine antigen that is 1) a nutritional virulence factor expressed on the bacterial cell surface during infection, 2) widely conserved among strains, 3) highly immunogenic, and 4) a protective antigen based on its capacity to induce protective responses in immunized animals. In the present study, we show that the antibodies to OppA following vaccination mediate accelerated clearance in animals following pulmonary challenge...
December 4, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29201375/children-with-lymphadenitis-associated-with-bacillus-calmette-gu%C3%A3-rin-bcg-vaccination-do-not-experience-more-infections-when-compared-with-bcg-vaccinated-children-without-lymphadenitis-a-three-years-paired-cohort-in-mexico
#16
Enrique Chacon-Cruz, Jorge Luis Arellano-Estrada, Erika Lopatynsky-Reyes, Jorge Alvelais-Palacios, Chandra Becka
Objectives: Vaccination against tuberculosis with live-attenuated Bacillus Calmette-Guérin (BCG) is widely used even though its effectiveness is controversial. BCG-lymphadenitis (BCG-LA) is its most common complication. Some studies have proposed that BCG-LA can be associated with primary immunodeficiencies (PIs). This study's aim is to see whether patients who developed BCG-LA (named as 'LA') developed more infections than BCG-vaccinated children without BCG-LA (named as 'NON-LA'). Methods: From January 2009 to April 2014, 31 LA children were seen at the outpatient clinic of the General Hospital of Tijuana, Mexico...
August 2017: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/29200185/early-vaccine-type-pneumococcal-acute-otitis-media-does-not-predispose-to-subsequent-otitis-when-compared-to-early-acute-otitis-media-due-to-other-bacterial-etiology
#17
Arto A Palmu, Mika Lahdenkari
BACKGROUND: Prevention of acute otitis media (AOM), and especially recurrence and biofilm formation, by pneumococcal conjugate vaccines (PCV) has been hypothesized to be due to prevention of early episodes triggering the vicious cycle. We tested the specific role of vaccine-type pneumococcal AOM in this hypothesis. METHODS: In the phase III randomized, double-blind FinOM Vaccine Trial conducted in 1995-99 children received PCV7 or hepatitis B vaccine as control at 2/4/6/12 months of age and were followed for AOM...
December 1, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29197892/relapse-of-b-cell-acute-lymphoblastic-leukaemia-presenting-as-right-aural-polyp-with-facial-and-mandibular-nerves-palsy
#18
C Shiun Chuen, M K Md Daud, N A Che Jalil, H Hazmi
A patient presenting with an ear polyp is a common finding in otorhinolaryngology practice. The common causes include chronic otitis media and cholesteatoma. We report an adult female patient with a history of acute leukaemia presenting with chronic otitis media symptoms and right ear polyp. She was subsequently diagnosed as relapse of B-cell acute lymphoblastic leukaemia based on histopathological examination. The presentation may be similar to an inflammatory pathology of the middle ear, making it misleading...
October 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/29194857/computed-tomographic-characteristics-of-pneumolabyrinth-in-a-french-bulldog-with-otitis-media-and-externa
#19
Audrey Belmudes, Jérôme Couturier, Guillaume Gory, Eddy Cauvin, Guillaume Condamin, Michael Rabillard, Delphine Rault
A four-year-old female French bulldog was presented for evaluation of acute, left-sided peripheral vestibular syndrome. Computed tomographic (CT) examination of the head revealed the presence of air within the left cochlea and vestibule, consistent with pneumolabyrinth. This was concurrent with ipsilateral otitis media and externa. Pneumolabyrinth is an uncommon finding in humans and is most frequently due to head trauma and temporal bone fracture. This is the first report describing pneumolabyrinth in a dog, apparently of nontraumatic origin in this case...
December 1, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29194211/publishing-trends-in-otology-and-neurotology
#20
Ryan Boerner, Jonathan L Hatch, Elizabeth Harruff, Shaun A Nguyen, Habib G Rizk, Ted A Meyer, Paul R Lambert, Theodore R McRackan
OBJECTIVES: 1) Describe publishing trends for otologic/neurotologic disorders over a 35-year span. 2) Compare trends in publishing with disease prevalence. 3) Evaluate changes in topic and journal specific ranking scores over time. METHODS: PubMed searches were performed on 35 otologic/neurotologic disorders using medical subject headings (MeSH) terms from 1980 to 2015. Searches were limited in scope to the English language. A Mann-Kendall trend analysis evaluated changes in publication frequency as a discrete variable while correcting for total number of articles published per year...
November 29, 2017: Otology & Neurotology
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