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https://www.readbyqxmd.com/read/28815006/biomarkers-in-inflammometry-pediatric-asthma-utility-in-daily-clinical-practice
#1
REVIEW
Silvia Sánchez-García, Alicia Habernau Mena, Santiago Quirce
Asthma is a common disease in both high and lower income countries that starts early and persists often for life. A correct and accurate diagnosis, treatment and follow-up during childhood are essential for a better understanding of adult asthma and avoiding over- or under-treatment. Th2 inflammation in children with asthma symptoms is usually assessed by measuring with serum total IgE, blood eosinophilia and FeNO levels that may help to predict asthma, particularly in those infants and young children in whom lung function tests are difficult to perform...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28814851/effect-of-allergic-phenotype-on-treatment-response-to-inhaled-bronchodilators-with-or-without-inhaled-corticosteroids-in-patients-with-copd
#2
Shih-Lung Cheng, Hsu Hui Wang, Ching-Hsiung Lin
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder encompassing different phenotypes with different responses to treatment. The present 1-year, two-center hospital-based study investigated whether the plasma immunoglobulin E (IgE) level and/or eosinophil cell count could be used as biomarkers to stratify patients with COPD according to predicted responses to inhaled corticosteroids (ICS)-based therapy. METHODS: A hospital-data based cohort study of COPD patients treated at two territory hospital centers was conducted for 1 year...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28812907/recommended-reading-from-university-hospital-cleveland-fellows
#3
Amy Attaway, Mirna Ayache, Shrey Velani, Joanne McKell
We review three recent and very interesting articles that have come out in the literature that made us reconsider certain aspects of asthma. These studies ask us whether a biologic is emerging that can be used in patients with normal IgE and no evidence of eosinophilia, if late onset asthma is associated with cardiovascular disease, and finally how different types of environmental exposures can influence the development of asthma in farming cultures.
August 16, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28810320/-chinese-expert-consensus-on-the-diagnosis-and-treatment-of-eosinophilia-2017
#4
(no author information available yet)
No abstract text is available yet for this article.
July 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28808370/a-rare-case-of-strongyloides-hyperinfection-from-hypogammaglobulinemia
#5
Paidi Ramakrishna Reddy, Sujith M Thomas, A Rajalakshmi, Deepak Vijayan, Muraleedharan Raman
Strongyloides infection can range from asymptomatic eosinophilia to disseminated disease. Common in tropical and subtropical nations, it can lead to hyperinfection, an autoinfection increasing parasitic burden in immunocompromised. Cell-mediated immunity is important in combating parasite infection. We present a case of Strongyloides hyperinfection in hypogammaglobulinemia which was refractory to conventional treatment but responded to immunoglobulin administration with complete resolution indicating role of humoral immunity also...
July 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28808190/cholesterol-crystal-embolization-following-plaque-rupture-a-systemic-disease-with-unusual-features
#6
Firas Ghanem, Deepthi Vodnala, Jagadeesh K Kalavakunta, Sridevi Durga, Noah Thormeier, Prem Subramaniyam, Scott Abela, George S Abela
Cholesterol crystal embolic (CCE) syndrome is often a clinically challenging condition that has a poor prognostic implication. It is a result of plaque rupture with release of cholesterol crystals into the circulation that embolize into various tissue organs. Plaque rupture seems to be triggered by an expanding necrotic core during cholesterol crystallization forming sharp tipped crystals that perforate and tear the fibrous cap. Embolizing cholesterol crystals then initiate both local and systemic inflammation that eventually lead to vascular fibrosis and obstruction causing symptoms that can mimic other vasculitic conditions...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28807083/microrna-let-7a-up-regulates-opn-expression-in-a-mouse-model-of-allergic-rhinitis
#7
H Yu, H Sun, Z Wang, Y Liu
OBJECTIVE: To investigate the effect of microRNA let-7a on OPN expression in a mouse model of allergic rhinitis. METHODS: Thirty-two mature female C57BL/6 mice were randomly divided into four groups, with eight mice in each group: microRNA let-7a, microRNA control, OVA and phosphate-buffered saline groups. The microRNA let-7a, microRNA control and OVA groups were sensitised with OVA to establish a mouse model of allergic rhinitis. Nose-scratching events were counted...
August 15, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28807078/the-relationship-between-lung-function-and-the-clinical-and-histopathological-features-in-chinese-patients-with-nasal-polyps
#8
Q L Zhao, L Yu, L L Zhi, P Jin, X X Zi, L Zhao, A Li, Y Y Tu, L Shi, H P Zhang
OBJECTIVE: To investigate lung function in Chinese patients suffering from chronic rhinosinusitis with nasal polyps and examine its association with histopathological features. METHODS: The lung function of 99 patients with nasal polyps was measured. Haematoxylin and eosin and immunohistochemistry staining were performed to evaluate any inflammatory cells and epithelial tissue remodelling. RESULTS: Predicted maximal expiratory flow rate at 25 per cent vital capacity was reduced (p < 0...
August 15, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28795997/celecoxib-induced-liver-injury-analysis-of-published-case-reports-and-cases-reported-to-the-food-and-drug-administration
#9
Pavan K Mukthinuthalapati, Robert J Fontana, Raj Vuppalanchi, Naga Chalasani, Marwan Ghabril
BACKGROUND: Celecoxib is a widely prescribed nonsteroidal anti-inflammatory drug, and has been associated with rare instances of idiosyncratic drug-induced liver injury (DILI). The aim of this study is to describe and analyze the salient features of published cases of celecoxib DILI. MATERIALS AND METHODS: A literature search using common terms for liver injury cross-referenced with celecoxib was undertaken from the year 2000 through June 2016. Identified cases were analyzed with respect to reported demographic and clinical data with descriptive...
August 8, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28794295/foreign-body-reaction-to-dialysis-chatheter-and-peritoneal-fluid-eosinophilia-in-a-child-on-continuous-ambulatory-peritoneal-dialysis
#10
Nuran Cetin, Nadide Melike Sav, Evrim Ciftci, Bilal Yildiz
Foreign body reaction is a tissue response against implanted materials. We described for the first time the eosinophilic peritonitis and foreign body giant cell reaction to dialysis catheter in a nonatopic child on continuous ambulatory peritoneal dialysis. We found tenderness, redness, and swelling without purulent discharge around the peritoneal catheter; increased eosinophil count in cloudy dialysis fluid; and blood and hyperechoic granulomatous formation appearance surrounding the peritoneal catheter on ultrasonography and foreign body giant cell reaction to dialysis catheter in pathologic examination of granulomatous lesionin in our patient...
July 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/28791259/toxoplasma-co-infection-prevents-th2-differentiation-and-leads-to-a-helminth-specific-th1-response
#11
Norus Ahmed, Timothy French, Sebastian Rausch, Anja Kühl, Katrin Hemminger, Ildiko R Dunay, Svenja Steinfelder, Susanne Hartmann
Nematode infections, in particular gastrointestinal nematodes, are widespread and co-infections with other parasites and pathogens are frequently encountered in humans and animals. To decipher the immunological effects of a widespread protozoan infection on the anti-helminth immune response we studied a co-infection with the enteric nematode Heligmosomoides polygyrus in mice previously infected with Toxoplasma gondii. Protective immune responses against nematodes are dependent on parasite-specific Th2 responses associated with IL-4, IL-5, IL-13, IgE, and IgG1 antibodies...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28791217/clinical-and-laboratory-features-of-human-dirofilariasis-in-russia
#12
Larisa Ermakova, Sergey Nagorny, Natalia Pshenichnaya, Yury Ambalov, Kerim Boltachiev
The article presents the results of the prospective study of 266 patients with dirofilariasis who received medical and diagnostic assistance in Rostov Scientific Research Institute of Microbiology and Parasitology in Rostov-on-Don, Russia from 2000 to 2016. We have assessed the features of the dynamics of epidemiology of this infection in several territories of the Russian Federation, depending on the social structure of patients. Immature females of dirofilaria were found most commonly in humans (82.9 ± 2...
2017: IDCases
https://www.readbyqxmd.com/read/28783701/ppar-%C3%AE-promotes-type-2-immune-responses-in-allergy-and-nematode-infection
#13
Ting Chen, Christopher A Tibbitt, Xiaogang Feng, Julian M Stark, Leona Rohrbeck, Lisa Rausch, Saikiran K Sedimbi, Mikael C I Karlsson, Bart N Lambrecht, Gunilla B Karlsson Hedestam, Rudi W Hendriks, Benedict J Chambers, Susanne Nylén, Jonathan M Coquet
A hallmark of immunity to worm infections and many allergies is a strong type 2 immune response. This is characterized by the production of cytokines interleukin-5 (IL-5) and IL-13 by adaptive T helper 2 (TH2) cells and/or type 2 innate lymphoid cells. Peroxisome proliferator activated receptor-γ (PPAR-γ) is typically regarded as an anti-inflammatory factor. We report that TH2 cells express high levels of PPAR-γ in response to the allergen house dust mite and after infection with the parasite Heligmosomoides polygyrus Mice lacking PPAR-γ in T cells failed to effectively differentiate into IL-5- and IL-13-secreting cells and, hence, did not develop TH2 cell-associated pathologies, including goblet cell metaplasia and eosinophilia, in response to allergen challenge...
March 10, 2017: Science Immunology
https://www.readbyqxmd.com/read/28775112/acute-interstitial-nephritis-and-dress-syndrome-without-eosinophilia-associated-with-cefepime
#14
Irfan Qadri, Xu Zeng, Ruifeng Guo, Abhilash Koratala
No abstract text is available yet for this article.
August 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28770203/clinical-applications-of-the-eosinophilic-esophagitis-diagnostic-panel
#15
REVIEW
Ting Wen, Marc E Rothenberg
Eosinophilic esophagitis (EoE) is a recently recognized upper gastrointestinal allergic disorder characterized by esophageal dysfunction (e.g., dysphagia) and esophageal eosinophilia of ≥15 eosinophils/high-power field in patients who have persistent esophagitis even on proton pump inhibitor (PPI) therapy. The histologic method is the gold standard of EoE diagnosis. However, EoE clinical symptoms do not always correlate with histology, and the histologic method has sensitivity and specificity issues due to the patchiness of EoE and the subjective nature of the method...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28765819/a-review-of-42-asthmatic-children-with-allergic-bronchopulmonary-aspergillosis
#16
Ashok Shah, Shekhar Kunal
BACKGROUND: Allergic bronchopulmonary aspergillosis (ABPA) in children with asthma, not associated with cystic fibrosis, is yet to receive the recognition it deserves. OBJECTIVE: To highlight the presentation of ABPA in children with asthma. METHODS: This retrospective review documents the occurrence of pediatric ABPA over a period of 31 years in one unit. Children with asthma, eosinophilia and infiltrates on chest radiograph were screened for ABPA...
July 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28765816/classification-of-chronic-rhinosinusitis-according-to-a-nasal-polyp-and-tissue-eosinophilia-limitation-of-current-classification-system-for-asian-population
#17
REVIEW
Sung-Woo Cho, Dae Woo Kim, Jeong-Whun Kim, Chul Hee Lee, Chae-Seo Rhee
Chronic rhinosinusitis (CRS) can be classified according to the presence of a nasal polyp (NP): CRS with NP (CRSwNP) and CRS without NP (CRSsNP). CRSwNP has characteristics with high infiltration of tissue eosinophilia with a burst of Th2 inflammatory cytokine. However recent findings in Eastern Asia countries suggest that CRSwNP can be divided according to the presence of tissue eosinophilia. Thus, CRSwNP can be classified into eosinophilic and noneosinophilic. Eosinophilic CRSwNP seems to have different immunological and clinical feature compared to noneosinophilic CRSwNP...
July 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28764210/kimura-s-disease-without-peripheral-eosinophilia-an-unusual-and-challenging-case-simulating-venous-malformation-on-imaging-studies-case-report-and-review-of-literature
#18
REVIEW
Vivek Dokania, Digvijay Patil, Ketan Agarwal, Prajakta Thakur, Piyush Prajapati
Kimura's Disease (KD) is a rare chronic inflammatory disorder presenting as multiple painless solitary subcutaneous nodules, predominantly in the head and neck region and frequently associated with regional lymphadenopathy and/or salivary gland involvement. Because of painless nature and indolent course, there is usually a delay in the patient's presentation. KD may radiologically mimic other chronic inflammatory conditions like tuberculosis, vascular malformations and neoplasms. Clinical correlation and histological evaluation along with elevated peripheral eosinophil and serum IgE level are considered important for confirmatory diagnosis...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28764169/histomorphological-spectrum-of-duodenal-pathology-in-functional-dyspepsia-patients
#19
Anita Aujenath Chaudhari, Sharada Raju Rane, Meenal Vitthal Jadhav
INTRODUCTION: Functional Dyspepsia (FD) is one of the most common causes of gastrointestinal symptoms aetiology of which is poorly understood. AIM: To study duodenal histomorphological features and their relationship with Helicobacter pylori (H Pylori) infection in patients of FD. MATERIALS AND METHODS: This case control study included 50 cases of FD patients selected according to Rome III criteria and 30 age and sex matched controls. These were subjected to oesophago-gastro-duodenoscopy, rapid urease test for detection of H...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28763131/the-effect-of-allergen-induced-bronchoconstriction-on-concentration-of-5-oxo-ete-in-exhaled-breath-condensate-of-house-dust-mite-allergic-patients
#20
Krzysztof Kowal, Anna Gielicz, Marek Sanak
BACKGROUND: Arachidonic acid metabolites regulate several aspects of airway function including inflammation, muscle contraction and mucous secretion. OBJECTIVE: The aim of this study was to evaluate concentration of selected 5-lipoxygenase (LOX) and cyclooxygenase (COX)-derived eicosanoids in exhaled breath condensate (EBC) during allergen induced bronchoconstriction. METHODS: The study was performed on 24 allergic rhinitis/asthma patients sensitized to a house dust mite (HDM) Dermatophagoides pteronyssinus (Dp) and 13 healthy controls (HCs)...
August 1, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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