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https://www.readbyqxmd.com/read/29034454/successful-treatment-of-sapho-syndrome-with-apremilast
#1
S Adamo, J Nilsson, A Krebs, U Steiner, A Cozzio, L E French, A G A Kolios
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a rare disease with inflammatory osteoarticular and skin involvement. The pathogenesis of SAPHO syndrome remains unclear, but evidence suggests it may be an autoinflammatory disease triggered upon exposure to infectious agents in genetically predisposed individuals. Induction of the IL-23/Th17 axis as well as neutrophil activation seem to play a key role, and therapies targeting these immunological pathways, including TNF-inhibitors, ustekinumab, secukinumab and the IL-1 inhibitor anakinra are potential treatment options that need further investigation...
October 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29031417/-skin-pigmentation-induced-by-meropenem-and-levofloxacin
#2
E Garval, V Vuiblet, A Durlach, G Perceau, D Anuset, P Bernard
BACKGROUND: Various cutaneous side-effects, including, exanthema, pruritus, urticaria and Lyell or Stevens-Johnson syndrome, have been reported with meropenem (carbapenem), a rarely-prescribed antibiotic. Levofloxacin (fluoroquinolone), a more frequently prescribed antibiotic, has similar cutaneous side-effects, as well as photosensitivity. We report a case of cutaneous hyperpigmentation induced by meropenem and levofloxacin. PATIENTS AND METHODS: A 67-year-old male was treated with meropenem (1g×4 daily), levofloxacin (500mg twice daily) and amikacin (500mg daily) for 2 weeks, followed by meropenem, levofloxacin and rifampicin (600mg twice daily) for 4 weeks for osteitis of the fifth metatarsal...
October 11, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29028793/clinico-pathological-features-of-erythema-nodosum-leprosum-a-case-control-study-at-alert-hospital-ethiopia
#3
Edessa Negera, Stephen L Walker, Selfu Girma, Shimelis N Doni, Degafe Tsegaye, Saba M Lambert, Munir H Idriss, Yohanis Tsegay, Hazel M Dockrell, Abraham Aseffa, Diana N Lockwood
BACKGROUND: Leprosy reactions are a significant cause of morbidity in leprosy population. Erythema nodosum leprosum (ENL) is an immunological complication affecting approximately 50% of patients with lepromatous leprosy (LL) and 10% of borderline lepromatous (BL) leprosy. ENL is associated with clinical features such as skin lesions, neuritis, arthritis, dactylitis, eye inflammation, osteitis, orchitis, lymphadenitis and nephritis. ENL is treated mainly with corticosteroids and corticosteroids are often required for extended periods of time which may lead to serious adverse effects...
October 13, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28977552/synovitis-acne-pustulosis-hyperostosis-osteitis-sapho-paradoxical-reactions-and-different-responses-to-tumour-necrosis-factor-inhibitors
#4
Jean Liew, Teena Huan Xu, Cong-Qiu Chu
No abstract text is available yet for this article.
July 28, 2017: Rheumatology
https://www.readbyqxmd.com/read/28974253/osteitis-of-the-radius-following-bacillus-calmette-gu%C3%A3-rin-vaccination-at-birth-a-case-report
#5
Abdelmoneim E M Kheir, Salah A Ibrahim, Azza Abdelsatir, Mustafa E Bahar
BACKGROUND: The Bacillus Calmette-Guérin vaccine, which is used for the prevention of tuberculosis, is considered protective against the severe forms of childhood tuberculosis. However, some serious adverse reactions including osteitis of the long bones can occur. CASE PRESENTATION: We report a case of an 18-month-old Sudanese girl who presented at the age of 3 months with swelling of her left forearm following Bacillus Calmette-Guérin vaccination administered at birth...
October 4, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28971081/prevalence-of-femoroacetabular-impingement-morphology-in-asymptomatic-youth-soccer-players-magnetic-resonance-imaging-study-with-clinical-correlation
#6
Anthony Kerbes Yépez, Marcelo Abreu, Bruno Germani, Carlos Roberto Galia
OBJECTIVE: To determine the prevalence of femoroacetabular impingement morphology (FAIM), cam- or pincer-type, by magnetic resonance imaging (MRI) in asymptomatic adolescent soccer players, and to evaluate the possible correlation between alterations on MRI and clinical examination findings. METHODS: A cross-sectional study was conducted to determine the prevalence of FAIM in asymptomatic youth soccer players aged 13-18 years. A total of 112 hips in 56 players (mean age 15...
2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28968889/bone-involvement-in-monogenic-autoinflammatory-syndromes
#7
Brigitte Bader-Meunier, Erika Van Nieuwenhove, Sylvain Breton, Carine Wouters
Until recently the most common autoinflammatory diseases (AIDs) associated with bone disease in childhood included a few genetically complex (chronic non-bacterial osteomyelitis, synovitis, acne, pustulosis, hyperostosis and osteitis syndrome) and monogenic (Majeed syndrome, deficiency of IL-1 receptor antagonist, cherubism) AIDs. However, the spectrum of monogenic AIDs associated with bone manifestations has markedly expanded to include both recently identified diseases such as the type I interferonopathies and also newly recognized bone dysplasias in already established AIDs...
August 22, 2017: Rheumatology
https://www.readbyqxmd.com/read/28968681/osteitis-as-a-manifestation-of-familial-mediterranean-fever
#8
Hakan Babaoglu, Ozkan Varan, Hamit Kucuk, Aynur Turan, Abdurrahman Tufan
No abstract text is available yet for this article.
July 27, 2017: Rheumatology
https://www.readbyqxmd.com/read/28968231/pustulotic-arthro-osteitis-sonozaki-syndrome-a-rare-case-report
#9
Hatice Resorlu, Besir Sahin Inceer, Sevilay Kılıc, Selda Isık
Pustulotic arthro-osteitis is a rare disease involving the skin and musculoskeletal system that was first described by Sonozaki. Onset is frequently seen at age 30-40. The prevalences between the sexes are similar. Palmoplantar pustulosis and sternoclavicular joint involvement are the most typical findings. It may be difficult to distinguish seronegative spondyloarthropathies and SAPHO syndrome due to sacroiliac joint, vertebral column and peripheral joint involvement. Arthritis being non-erosive and short-lived in character and the absence of deformity or contracture in the joints are significant clinical characteristics...
September 22, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28955589/the-effects-of-amoxicillin-with-or-without-clavulanic-acid-on-the-postoperative-complaints-after-third-molar-surgery-a-retrospective-chart-analysis
#10
Alparslan Esen
PURPOSE: The aim of this chart-based retrospective study was to evaluate the effects of orally administered amoxicillin alone or amoxicillin combined with clavulanic acid on the frequency of post-operative complications and patients' comfort after mandibular third molar surgery. MATERIALS AND METHODS: The records of patients who had undergone lower third molar surgery between October 2014 and December 2015 were examined. A total of 62 patients who had fully impacted teeth in mesioangular position and who had been prescribed same type and dose of anti-inflammatory drug were included in this study...
2017: J Istanb Univ Fac Dent
https://www.readbyqxmd.com/read/28941759/osteitis-pubis-in-professional-football-players-mri-findings-and-correlation-with-clinical-outcome
#11
Francesco Gaudino, Daniel Spira, Yannic Bangert, Henning Ott, Bruno Beomonte Zobel, Hans-Ulrich Kauczor, Marc-André Weber
BACKGROUND AND PURPOSE: Osteitis pubis (OP), a common pathology in elite athletes, is an aseptic inflammatory process of the pubic symphysis bone, and may involve surrounding soft tissues, tendons and muscles. OP is typically characterized by (often recurring) groin pain and is an important cause of time-off from sports activity in athletes. Aim of this retrospective study was to analyze magnetic resonance imaging (MRI) findings in professional football players with clinical diagnosis of OP and to correlate MRI findings with clinical outcome...
September 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28924111/synovitis-acne-pustulosis-hyperostosis-osteitis-sapho-syndrome-with-significant-bilateral-pleural-effusions
#12
Shoichi Hasegawa, Hiroki Yabe, Naoya Kaneko, Eri Watanabe, Takahisa Gono, Chihiro Terai
We herein report a rare case of a 66-year-old woman who had synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome with marked sternal osteitis and bilateral pleural effusions. SAPHO syndrome was diagnosed based on the characteristic features of a hyperostotic sternum and thoracic spine. The inflammatory changes of sternal osteitis and involvement of the adjacent soft tissue were assumed to be the cause of the pleural effusions. The effusions decreased during the natural course of the disease and resolved after methotrexate therapy...
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28916742/haplotype-of-the-interleukin-17a-gene-is-associated-with-osteitis-after-bacillus-calmette-guerin-vaccination
#13
Matti Korppi, Johanna Teräsjärvi, Milla Liehu-Martiskainen, Eero Lauhkonen, Juho Vuononvirta, Kirsi Nuolivirta, Liisa Kröger, Laura Pöyhönen, Minna K Karjalainen, Qiushui He
Bacillus Calmette-Guerin (BCG) osteitis was more common in Finland than elsewhere at the time when universal BCG vaccinations were given to Finnish newborns. There is evidence that IL-17 plays a role in the defense against tuberculosis. The aim of this study was to evaluate the associations of IL17A rs4711998, IL17A rs8193036 and IL17A rs2275913 single-nucleotide polymorphisms (SNPs) with the risk of BCG osteitis after newborn vaccination. IL17A rs4711998, rs8193036 and rs2275913 SNPs were determined in 131 adults had presented with BCG osteitis after newborn BCG vaccination...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28900835/osteitis-fibrosa-cystica-a-forgotten-radiological-feature-of-primary-hyperparathyroidism
#14
Waldemar Misiorowski, Izabela Czajka-Oraniec, Magdalena Kochman, Wojciech Zgliczyński, John P Bilezikian
Although bone disease and stone disease are the universally accepted classical manifestations of primary hyperparathyroidism, clinical parathyroid bone disease is rarely seen today in the United States (<5% of patients) and Western Europe. Nevertheless, in a given patient, classical skeletal involvement can be the first sign of primary hyperparathyroidism, but not recognized because it is not usually included, anymore, in the differential diagnosis of this manifestation of skeletal disease. We describe four cases of primary hyperparathyroidism in which the first clinical manifestation of the disease was a pathological fracture that masqueraded as a malignancy...
September 12, 2017: Endocrine
https://www.readbyqxmd.com/read/28894334/spondyloarthropathy-diagnostic-imaging-criteria-for-the-detection-of-sacroiliitis
#15
Moacir Ribeiro de Castro, Sonia de Aguiar Vilela Mitraud, Marina Celli Francisco, Artur da Rocha Corrêa Fernandes, Eloy de Ávila Fernandes
Diagnostic imaging is crucial to the diagnosis and monitoring of spondyloarthropathies. Magnetic resonance imaging is the most relevant tool for the early detection of sacroiliitis, allowing the institution of therapeutic strategies to impede the progression of the disease. This study illustrates the major criteria for a magnetic resonance imaging-based diagnosis of spondyloarthropathy. The cases selected here present images obtained from the medical records of patients diagnosed with sacroiliitis over a two-year period at our facility, depicting the active and chronic, irreversible forms of the disease...
July 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28884797/sapho-syndrome-associated-with-hidradenitis-suppurativa-and-pyoderma-gangrenosum-successfully-treated-with-adalimumab-and-methotrexate-a-case-report-and-review-of-the-literature
#16
REVIEW
Dunja A Vekic, Jane Woods, Peter Lin, Geoffrey D Cains
SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is a rare inflammatory condition describing the combination of skin, bone, and joint manifestations that has a heterogeneous presentation. We report a case of severe SAPHO syndrome in association with hidradenitis suppurativa and pyoderma gangrenosum in a 27-year-old male. The patient had an initial migratory arthritis affecting the knees, ankles, metacarpophalangeal joints, proximal interphalangeal joints, wrists, shoulder, and lower back, which progressed to a persistent arthritis and swelling at the sternum, shoulders, wrists, hands, feet, and lower back...
September 7, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28880693/clinical-features-and-radiological-findings-of-67-patients-with-sapho-syndrome
#17
Hiroshi Okuno, Munenori Watanuki, Yoshiyuki Kuwahara, Akira Sekiguchi, Yu Mori, Shin Hitachi, Keiki Miura, Ken Ogura, Mika Watanabe, Masami Hosaka, Masahito Hatori, Eiji Itoi, Katsumi Sato
OBJECTIVES: The purpose of this study was to facilitate the understanding of the SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis) syndrome by analyzing the clinical and radiological features of 67 Japanese patients with SAPHO syndrome. METHODS: Sixty-seven Japanese patients (female/male: 44/23, mean age at onset: 48.5 years) were diagnosed with SAPHO syndrome from 2002 to 2013 at our hospital. Medical records and radiological imaging of these patients were retrospectively reviewed...
September 7, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28876598/spectrum-of-disease-and-outcome-of-primary-amputation-for-diabetic-foot-sepsis
#18
S Cheddie, C Manneh, H Zulu
BACKGROUND: Guillotine amputation for diabetic foot sepsis followed by an elective refashioning of the stump is regarded as standard practice. Primary amputation is associated with higher reamputation rates. METHOD: A prospective cohort study of 85 patients who underwent surgery for diabetic foot sepsis from 2014 to 2016 at Madadeni Provincial Hospital, KwaZulu-Natal was done. Ethical approval was granted. The Wagner classification (Wag) was used to classify disease severity...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28845531/radical-chest-wall-resection-and-hyperfractionated-accelerated-radiotherapy-for-radiation-associated-angiosarcoma-of-the-breast-a-safe-and-effective-treatment-strategy
#19
Elysia K Donovan, Thomas Corbett, Jasmin Vansantvoort, Ipshita Kak, Snezana Popvic, Barbara Heller
Radiation-associated angiosarcomas (RAS) of the breast are vascular tumors arising in a previous radiation field for primary breast cancer. They occur rarely but confer a high probability of local recurrence (LR) and poor prognosis. A wide range of treatment strategies exists due to limited evidence, and although resection is the definitive treatment, LR rates remain high. It has been suggested hyperfractionated accelerated radiotherapy (HART) has the potential to prevent LR. The sarcoma group at the Juravinski Cancer Centre (JCC) reports our experience of nine patients treated with radical resection and adjuvant HART...
August 27, 2017: Breast Journal
https://www.readbyqxmd.com/read/28819489/-elastic-stable-intramedullary-nailing-esin-in-the-treatment-of-both-bone-forearm-fractures-in-the-child-about-87-cases
#20
Saad Andaloussi, Mohamed Amine Oukhouya, Othmane Alaoui, Karima Atarraf, Lamiae Chater, My Abderrahmane Afifi
This study aims to describe the complications of elastic stable intramedullary nailing (ESIN) in the treatment of both-bone forearm diaphyseal fractures in the child. Between January 2009 and December 2013, 87 children with both-bone forearm diaphyseal fractures were treated by elastic stable intramedullary nailing with Métaizeau nails. 76 boys and 11 girls, with an average age of 12 years, were enrolled in the study. Nailing was promptly performed in 50 cases and after secondary displacement during plaster-cast treatment in the other cases...
2017: Pan African Medical Journal
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