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https://www.readbyqxmd.com/read/29924019/case-report-successful-treatment-of-refractory-sapho-syndrome-with-the-jak-inhibitor-tofacitinib
#1
Qiao Yang, Yumo Zhao, Chen Li, Yaping Luo, Weixin Hao, Wen Zhang
INTRODUCTION: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is an autoinflammatory disorder without standardized treatment. Janus kinase (JAK) inhibitors can block a range of cytokines and might possess significant anti-inflammatory activity. Here, we report the first case of efficacious treatment of refractory SAPHO syndrome with the JAK inhibitor tofacitinib. CASE PRESENTATION: A 44-year-old woman presented with arthralgia in the right wrist and complained of having difficulty in doing housework...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29922466/hidradenitis-suppurativa-with-sapho-syndrome-maintained-effectively-with-adalimumab-methotrexate-and-intralesional-corticosteroid-injections
#2
Erika L Crowley, Ashley O'Toole, Melinda J Gooderham
Introduction: Hidradenitis suppurativa and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome are chronic, debilitating diseases involving apocrine gland-bearing skin inflammation and bone inflammation, respectively. Although both often present with multiple comorbidities, single patient co-presentation is rare. Methods/Results: This study reports the 8-year treatment course of a 40-year-old man with hidradenitis suppurativa and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome, and reviews relevant literature...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29921080/-to-explore-the-role-of-ct-scan-in-the-diagnosis-of-eosinophilic-chronic-rhinosinusitis
#3
C M Zhu, H B Liu, W X Wu, C Xu
Objective: We explored the role of CT scan in the diagnosis of eosinophilic chronic rhinosinusitis (ECRS) in sinus osteitis for a better guidance of clinic and treatment. Method: A total of 127 patients with chronic rhinosinusitis who underwent primary surgery were collected(52 patients were ECRS). Seventy-five patients with NonECRS performed global osteitis scoring scale (GOSS) osteitis score on the patient's preoperative sinus CT. Mamn-Whitney U analysis was used to compare the GOSS osteitis scores between the two groups...
June 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29910478/short-and-long-term-success-of-transfixation-pin-casts-used-to-stabilize-long-bone-fractures-in-ruminants
#4
Joseph W Lozier, Andrew J Niehaus, Andrew Muir, Jeffrey Lakritz
Transfixation pin casts (TPC) may be useful in management of fractures in ruminants. A retrospective study was conducted to report the uses, complications, and outcomes of TPC in ruminant fracture stabilization. Twenty-five cattle, 7 goats, and 7 sheep with long bone fractures managed with TPC met the inclusion criteria. Long-term outcome was assessed from telephone interviews with owners. Thirty-one animals (79%) survived to removal of external coaptation and return to the farm. Common complications included pin-hole osteitis and disuse osteopenia...
June 2018: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/29898183/maxillomandibular-giant-osteosclerotic-lesions
#5
Constantino Ledesma-Montes, María Dolores Jiménez-Farfán, Juan Carlos Hernández-Guerrero
INTRODUCTION: Giant Osteosclerotic Lesions (GOLs) are a group of rarely reported intraosseous lesions. Their precise diagnosis is important since they can be confused with malignant neoplasms. OBJECTIVE: This retrospective study aimed to record and analyze the clinical and radiographic Giant Osteosclerotic Lesions (GOLs) detected in the maxillomandibular area of patients attending to our institution. Materials and Methods: Informed consent from the patients was obtained and those cases of 2...
June 11, 2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29893226/the-pathogenesis-of-psoriatic-arthritis
#6
REVIEW
Douglas J Veale, Ursula Fearon
Psoriatic arthritis is a chronic, immune-mediated, inflammatory arthropathy that presents with inflammation of the joints and entheses, including those of the axial skeleton, and is associated with increased mortality from cardiovascular disease. Diagnosis is primarily based on clinical phenotype because of the diversity of the associated features, which can include skin and nail disease, dactylitis, uveitis, and osteitis. Improved understanding of the pathogenesis of psoriatic arthritis has led to the development of effective biologics and small-molecular drugs targeting specific cytokines and signalling pathways, which can prevent disease progression and improve quality of life...
June 2, 2018: Lancet
https://www.readbyqxmd.com/read/29875911/osteitis-of-the-cuboid-on-unknown-foreign-body
#7
Hassane Zejjari
No abstract text is available yet for this article.
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29859799/clinical-features-and-outcomes-of-bacille-calmette-gu%C3%A3-rin-bcg-induced-diseases-following-neonatal-bcg-tokyo-172-strain-immunization
#8
Rattanachai Rermruay, Supattra Rungmaitree, Sunsanee Chatpornvorarux, Chantapat Brukesawan, Orasri Wittawatmongkol, Keswadee Lapphra, Wanatpreeya Phongsamart, Nantaka Kongstan, Benjawan Khumcha, Kulkanya Chokephaibulkit
BACKGROUND: Bacille Calmette-Guérin (BCG) vaccination at birth may cause mild and benign local adverse effects (AE). More serious AE are rarely reported. OBJECTIVE: To describe clinical features and outcomes of BCG (Tokyo-172 strain)-induce diseases (BCG-ID) that required medical attention at a tertiary care center in Bangkok, Thailand. METHOD: We retrospectively reviewed medical records from January 2007 to December 2016 that were selected by ICD-10 codes...
May 30, 2018: Vaccine
https://www.readbyqxmd.com/read/29850279/mandibular-osteitis-fibrosa-cystica-as-first-sign-of-vitamin-d-deficiency
#9
Nour Mellouli, Raouaa Belkacem Chebil, Marwa Darej, Yosra Hasni, Lamia Oualha, Nabiha Douki
Introduction: Brown tumors of hyperparathyroidism are locally destructive bone lesions. They are the late clinical consequence of the disease. They can occur in primary, secondary, and rarely tertiary forms. They affect usually long bones and less frequently those of the maxilla. Case Report: Our 45-year-old female patient presented with a mandibular tumor next to the first right lower molar. At first, we have chosen tooth extraction and tumor excision. When the histological report showed the giant cell tumor we suspected a metabolic bone disorder...
2018: Case Reports in Dentistry
https://www.readbyqxmd.com/read/29849968/the-efficacy-of-1-betadine-mouthwash-on-the-incidence-of-dry-socket-after-mandibular-third-molar-surgery
#10
Dariush Hasheminia, Amirhossein Moaddabi, Saeid Moradi, Parisa Soltani, Mahsa Moannaei, Maryam Issazadeh
Background: Dry socket or alveolar osteitis is a delayed healing of alveolar bone after exodontia causing moderate to severe pain 2-4 days after extraction of teeth. Antibacterial agents such as antibiotics and chlorhexidine have been previously proved to prevent or reduce the incidence of dry socket. Betadine is a mixture of iodine and povidone which has bactericidal, antifungal and antiviral effects. The aim of the present study was to evaluate the effect of preoperative povidone iodine 1% mouthwash before surgical extraction of impacted mandibular third molar, however age, gender and oral hygiene were also considered...
May 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29849651/ac-cute-an-open-label-study-to-evaluate-progression-of-structural-joint-damage-and-inflammation-in-subjects-with-moderate-to-severe-rheumatoid-arthritis
#11
Paul Bird, Charles Peterfy, Peter Countryman, Hedley Griffiths, Rina Barrett, Peter Youssef, Fredrick Joshua, Stephen Hall
Aim: Examine the efficacy of once-weekly subcutaneous tocilizumab (SC-TCZ) on joint damage at 24 weeks based on radiography of the hands and feet and magnetic resonance imaging (MRI) of the hand in subjects with moderate to severe rheumatoid arthritis (RA). Methods: In this Australian open-label, multicentre, prospective, single-arm study, subjects received 162 mg SC-TCZ weekly. Primary endpoint was change in radiographic Genant-modified Total Sharp Score (TSS) between baseline and Week 24...
2018: International Journal of Rheumatology
https://www.readbyqxmd.com/read/29844940/diabetic-foot-syndrome-charcot-arthropathy-or-osteomyelitis-part-i-clinical-picture-and-radiography
#12
REVIEW
Aleksandra Konarzewska, Anna Korzon-Burakowska, Ludomira Rzepecka-Wejs, Iwona Sudoł-Szopińska, Edyta Szurowska, Michał Studniarek
One of significant challenges faced by diabetologists, surgeons and orthopedists who care for patients with diabetic foot syndrome is early diagnosis and differentiation of bone structure abnormalities typical of these patients, i.e. osteitis and Charcot arthropathy. In addition to clinical examination, the patient's medical history and laboratory tests, imaging plays a significant role. The evaluation usually begins with conventional radiographs. In the case of osteomyelitis, radiography shows osteopenia, lytic lesions, cortical destruction, periosteal reactions as well as, in the chronic phase, osteosclerosis and sequestra...
March 2018: Journal of Ultrasonography
https://www.readbyqxmd.com/read/29798124/-clinical-application-of-modified-global-osteitis-score-in-chronic-rhinosinusitis
#13
Y X Li, F Lin, L Cheng, Q Huang, Z X Huang, X Q Zhang, B Zhou
Objective: To compare GOSS and a newly proposed modified scoring system for assessment of CRS with osteitis. Method: Seventy-one CRS patients were enrolled prospectively.Their preoperative computed tomography (CT) were assessed for severity and extent of osteitis by two otolaryngologists using OsiriX DICOM Viewer software. The method of measurement was similar with GOSS, which retained scoring maxillary and sphenoid, producing a modified global osteitis score(rang: 0-20). Collected the history and completed VAS, SNOT-22, Lund-Kennedy, Lund-Mackay in preoperative...
November 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29796741/comparative-study-of-primary-and-secondary-closure-of-the-surgical-wound-after-removal-of-impacted-mandibular-third-molars
#14
Pavan Kumar Pachipulusu, Manjula S
AIM: Aim of the study is to compare the primary and secondary healing after surgical removal of impacted mandibular third molars, in terms of swelling, severity of pain, trismus, and periodontal healing between two types of closure. MATERIALS AND METHODS: A total of 60 patients, divided into two groups randomly: group A, with 30 patients in which primary closure was done; group B, with 30 patients in which secondary closure was done. A comparison between two groups was done in terms of postoperative pain, swelling, trismus at first, third, and seventh postoperative days, and periodontal healing near adjacent second molar after 6 months...
May 23, 2018: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29788984/f-18-fdg-pet-ct-in-26-patients-with-sapho-syndrome-a-new-vision-of-clinical-and-bone-scintigraphy-correlation
#15
Xiaochuan Sun, Chen Li, Yihan Cao, Ximin Shi, Li Li, Weihong Zhang, Xia Wu, Nan Wu, Hongli Jing, Wen Zhang
BACKGROUNDS: Whole-body bone scintigraphy (WBBS) and MRI are widely used in assessment of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. However, the value of F-18 fluorodeoxyglucose-positron emission tomography/computed tomography (18 F-FDG PET/CT) in SAPHO syndrome was unclear. The aim of this study was to characterize the manifestation of SAPHO syndrome on 18 F-FDG PET/CT and explore its relationship with clinical symptoms and WBBS. METHODS: Twenty-six patients who suffered from SAPHO syndrome and had undergone whole-body 18 F-FDG PET/CT were recruited in Peking Union Medical College Hospital from 2004 to 2016...
May 22, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29781675/axial-sesamoiditis-in-the-horse-a-review
#16
Christelle Le Roux, Ann Carstens
Axial sesamoiditis or osteitis of the proximal sesamoid bones (PSBs) in the horse is described as a rare condition. The cause remains unknown and speculative, with vascular, infectious, and traumatic aetiologies implicated. It is specifically associated with injury of the palmar or plantar ligament (PL), also known as the intersesamoidean ligament. Imaging findings are generally rewarding and radiological changes are typical, if not pathognomonic, for the condition. Lesions consist of bone lysis at the apical to mid-body axial margins of the PSBs, with variable degrees of joint effusion...
March 29, 2018: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/29777787/patency-and-incontinence-rates-after-robotic-bladder-neck-reconstruction-for-vesicourethral-anastomotic-stenosis-and-recalcitrant-bladder-neck-contractures-the-turns-experience
#17
Eric J Kirshenbaum, Lee C Zhao, Jeremy B Myers, Sean P Elliott, Alex J Vanni, Nima Baradaran, Bradley A Erickson, Jill C Buckley, Bryan B Voelzke, Michael A Granieri, Stephen J Summers, Benjamin N Breyer, Atreya Dash, Aaron Weinberg, Nejd F Alsikafi
OBJECTIVE: To review a robotic approach to recalcitrant bladder neck obstruction and assess success and incontinence rates. METHODS: Patients with a recalcitrant bladder neck contracture or vesicourethral anastomotic stenosis who underwent robotic bladder neck reconstruction (RBNR) were identified. We reviewed patient demographics, medical history, etiology, previous endoscopic management, cystoscopic and symptomatic outcomes, urinary continence and complications...
May 16, 2018: Urology
https://www.readbyqxmd.com/read/29755804/sapho-syndrome-masquerading-as-metastatic-breast-cancer
#18
Devin Malik, Richa Handa, Andrew Petraszko, Sheela Tejwani
SAPHO syndrome is a rare clinical entity composed of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO). We describe a case of SAPHO syndrome masquerading as metastatic breast cancer in a patient with localized breast cancer who presented with cord compression. There was no pathologic evidence of metastatic cancer; however, a bone scan indicated osseous involvement. After multidisciplinary review of images and with additional findings of pustulosis and acne, a clinical diagnosis of SAPHO was made...
2018: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/29743324/spondyloarthritis-in-the-democratic-republic-of-the-congo-a-prospective-hospital-based-study
#19
Pierrot Lebughe, Kurt de Vlam, Rene Westhovens, Jean-Marie Mbuyi-Muamba, Jean Jacques Malemba
OBJECTIVES: To determine the spectrum of spondyloarthritis (SpA) in outpatients with symptoms of rheumatism attending two rheumatology practices in the Democratic Republic of the Congo. DESIGN: A descriptive prospective multicentre outpatient study. SETTING: The present study analysed 6 months data (from 1 December 2012 till 31 May 2013). PARTICIPANTS: Nine hundred and eighty-four consecutive outpatients were studied...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29742264/chlorhexidine-for-prevention-of-alveolar-osteitis-a-randomised-clinical-trial
#20
Diego Halabi, Jose Escobar, Cyntia Alvarado, Nicolette Martinez, Carlos Muñoz
Objective To determine the effectiveness of chlorhexidine 0.12% mouthwash (CHX) after tooth extraction for the prevention of alveolar osteitis (AO). Material and methods We conducted a double-blind randomised clinical trial stratified by risk factors. We enrolled a cohort of 822 patients who underwent dental extractions, and were considered to be at risk of developing AO (previous surgical site infection, traumatic extraction, and tobacco smoking). After extraction, patients were randomly allocated for CHX group or placebo group, matched by risk factors...
2018: Journal of Applied Oral Science: Revista FOB
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