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https://www.readbyqxmd.com/read/27888915/biofilm-and-osteitis-in-refractory-chronic-rhinosinusitis
#1
REVIEW
Yi Chen Zhao, Peter-John Wormald
Our understanding of chronic rhinosinusitis (CRS) show biofilm and osteitis play a role in the disease's pathogenesis and refractory. Studies point to its role in pathogenesis and poor prognosis. Outside the research laboratory, biofilm detection remains difficult and specific treatment remains elusive. It is believed that osteitis is a nidus of inflammation and occurs more commonly in patients with refractory CRS. However, osteitis may be exacerbated by surgery and a marker of refractory disease, not a causative agent...
February 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/27888647/microarray-analysis-of-the-genes-associated-with-osteitis-in-chronic-rhinosinusitis
#2
Ceren Günel, Benjamin S Bleier, Gökay Bozkurt, Nuket Eliyatkin
OBJECTIVES/HYPOTHESIS: Although numerous studies have examined epithelial remodeling in chronic rhinosinusitis (CRS), bone remodeling (osteitis) has only recently gained attention as a potential significant contributor to the pathophysiology of recalcitrant CRS. The purpose of this study was to compare gene expression profiles between osteitic bone and the adjacent diseased mucosa in patients with CRS to determine which genes affect mucosal and bony remodeling. STUDY DESIGN: Prospective experimental analysis...
November 26, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27872954/osteitis-a-retrospective-feasibility-study-comparing-single-source-dual-energy-ct-to-mri-in-selected-patients-with-suspected-acute-gout
#3
Torsten Diekhoff, Michael Scheel, Sandra Hermann, Jürgen Mews, Bernd Hamm, Kay-Geert A Hermann
OBJECTIVE: Dual-energy computed tomography detects tophi in patients with chronic gout. However, other information that can be obtained from the same scan is not the focus of the current research, e.g., the detection of bone marrow edema (BME) using virtual bone marrow imaging (VBMI). The aim of this study was to evaluate if BME in patients with acute arthritis can be detected with VBMI using magnetic resonance imaging (MRI) as the standard of reference. MATERIALS AND METHODS: This retrospective study included 11 patients who underwent both MRI and dual-energy computed tomography (mean interval of 40 days)...
November 21, 2016: Skeletal Radiology
https://www.readbyqxmd.com/read/27853411/the-correspondence-between-magnetic-resonance-images-and-the-%C3%A2-clinical-and-intraoperative-status-of-patients-with-spinal-tumors
#4
Grzegorz Guzik
ABSTRACT INTRODUCTION: Surgical treatment of tumors, particularly metastases to the spine, has become increasingly common owing to the progress in anesthesiology and spinal surgery and greater detectability. The patients qualified for surgeries are those with mechanical pain, fracture or at risk of vertebral fracture or neurological complications. The basis for qualification for different types of surgeries is clinical and imaging examination, particularly MRI and CT. Qualification should always be multidisciplinary and requires understanding and knowledge of its most essential aspects...
May 2016: Current Medical Imaging Reviews
https://www.readbyqxmd.com/read/27846749/synovitis-of-sternoclavicular-and-peripheral-joints-can-be-detected-by-ultrasound-in-patients-with-sapho-syndrome
#5
Masataka Umeda, Shin-Ya Kawashiri, Ayako Nishino, Tomohiro Koga, Kunihiro Ichinose, Toru Michitsuji, Toshimasa Shimizu, Shoichi Fukui, Yoshikazu Nakashima, Yasuko Hirai, Naoki Iwamoto, Toshiyuki Aramaki, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Yukitaka Ueki, Atsushi Kawakami
OBJECTIVES: To determine the prevalence of ultrasonographic abnormalities of sternoclavicular joints (SCJ) and peripheral joints (PJ) in patients with synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome. METHODS: Thirteen patients with SAPHO syndrome who fulfilled diagnostic criteria proposed by Kahn for SAPHO syndrome 2003 and 13 healthy individuals age- and sex-matched were enrolled. Synovitis, defined by synovial hypertrophy with power Doppler (PD) signals, of the SCJ and the PJ including wrist, MCP, PIP and the other symptomatic joints were evaluated by ultrasound (US)...
November 16, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27843268/comparative-efficacy-of-amoxicillin-clavulanic-acid-and-levofloxacin-in-the-reduction-of-postsurgical-sequelae-after-third-molar-surgery-a-randomized-double-blind-clinical-trial-in-a-nigerian-university-teaching-hospital
#6
Kizito Chioma Ndukwe, Ramat Oyebunmi Braimah, John Foluso Owotade, Stephen Babatunde Aregbesola
BACKGROUND: The most common sequelae after surgical removal of mandibular third molar are pain, trismus, swelling, and dysphagia. However, these symptoms can also signal the onset of surgical site infection and alveoli osteitis. The aim of this study was to evaluate the efficacy of prophylactic amoxicillin/clavulanic acid and levofloxacin and preemptive therapy of amoxicillin/clavulanic acid in the reduction of postinflammatory complications, surgical site infection, and alveolar osteitis following the third molar surgery...
July 2016: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/27834111/computed-tomography-and-histopathological-evaluation-of-osteitis-in-rabbit-models-with-rhinosinusitis
#7
Yi Dong, Bing Zhou, Xiangdong Wang, Zhenxiao Huang, Mingjie Wang, Yunchuan Li, Hongrui Zang, Erzhong Fan, Ying Li, Xinyan Wang
CONCLUSIONS: There is clear correspondence between HU and histopathological evaluation of osteitis. It is feasible to evaluate bone remodeling in rabbit models with rhinosinusitis by measuring the HU. OBJECTIVE: The objective of this study was to determine whether the HUs of rabbit CRS models can be used to objectively evaluate the degree of osteitis. METHODS: Sixty rabbit models were inoculated with staphylococcus aureus. The rabbits were divided into three groups...
November 11, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27811865/alveolar-osteitis-what-s-in-a-name
#8
K Ali
No abstract text is available yet for this article.
November 4, 2016: British Dental Journal
https://www.readbyqxmd.com/read/27785852/severe-osteoarticular-involvement-in-isotretinoin-triggered-acne-fulminans-two-cases-successfully-treated-with-anakinra
#9
T Oranges, A Insalaco, A Diociaiuti, C Carnevale, R Strippoli, G Zambruno, P Tomà, M El Hachem
Acne fulminans (AF) is a severe form of inflammatory and ulcerated acne associated with fever, malaise, joint swellings and polyarthralgia(1) . Osteoarticular lesions are often described and can be radiologically indistinguishable from those observed in synovitis - acne - pustulosis - hyperostosis and osteitis (SAPHO) syndrome(2,3) . SAPHO is an autoinflammatory disease characterized by osteoarticular and cutaneous manifestations, the latter including nodular and fulminans acne, hidroadenitis suppurativa, and palmo-plantar pustolosis(3) ...
October 27, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27785520/-joint-infections-of-the-hand
#10
F Unglaub, M F Langer, J M Unglaub, B Hohendorff, L P Müller, P Hahn, S Löw, C K Spies
Joint infections of the hand may lead to irreversible lesions and impairment of hand function due to early cartilage damage. Furthermore, persistent infections which are not treated immediately can cause osteitis and/or spread systemically. Finger joints are prone to infection due to bite wounds or crush and sharp injuries. Whereas the wrist is often affected in patients with immunosuppression or chronic diseases, such as diabetes mellitus. If diagnosis and therapy are delayed, joint damage may be inevitable...
October 26, 2016: Der Unfallchirurg
https://www.readbyqxmd.com/read/27775461/effect-of-a-treat-to-target-cyclosporin-on-mri-assessed-synovitis-osteitis-tenosynovitis-bone-erosion-and-joint-space-narrowing-in-early-rheumatoid-arthritis-results-from-a-2-year-randomized-double-blind
#11
S Møller-Bisgaard, B J Ejbjerg, I Eshed, K Hørslev-Petersen, M L Hetland, A G Jurik, H Thomsen, T Torfing, K Stengaard-Pedersen, P Junker, N S Krogh, T Lottenburger, T Ellingsen, L S Andersen, H Skjødt, A J Svendsen, U Tarp, I T Hansen, J Pødenphant, J K Pedersen, H Lindegaard, L G Hanson, A Vestergaard, D Glinatsi, M Østergaard
OBJECTIVES: To investigate whether a treat-to-target strategy based on methotrexate (MTX) and intra-articular (IA) betamethasone suppresses magnetic resonance imaging (MRI)-determined measures of disease activity and reduces joint destruction in early rheumatoid arthritis (eRA) patients, and to investigate whether concomitant cyclosporin A (CyA) provides an additional effect. METHOD: In the 2-year randomized, double-blind, treat-to-target trial CIMESTRA, 160 patients with eRA (< 6 months) were randomized to MTX, intra-articular betamethasone and CyA, or placebo CyA...
October 24, 2016: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/27771829/a-retrospective-study-of-osteomyelitis-and-osteonecrosis-of-the-jaws-and-its-etiologic-implication-of-bisphosphonate-in-asians
#12
Sung Ok Hong, Chae-Yoon Lee, Junho Jung, Deog-Yoon Kim, Christian Walter, Yong-Dae Kwon
OBJECTIVE: The objective of this study were to find the annual case trend of inflammatory jawbone diseases and to investigate the impact of medication-related osteonecrosis of the jaws (MRONJ). MATERIAL AND METHODS: A retrospective study of 372 patients diagnosed with inflammatory jawbone condition except for alveolar osteitis from 2007 to 2015 was initiated. History taking and investigation of etiologic factors MRONJ, osteoradionecrosis (ORN), odontogenic infection, foreign body, and trauma were investigated...
October 22, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27755461/association-of-mbl2-tlr1-tlr2-and-tlr6-polymorphisms-with-production-of-ifn-%C3%AE-and-il-12-in-bcg-osteitis-survivors
#13
Laura Pöyhönen, Liisa Kröger, Heini Huhtala, Johanna Mäkinen, Kirsi Nuolivirta, Jussi Mertsola, Qiushui He, Matti Korppi
BACKGROUND: Interferon-gamma (IFN-γ) is a key cytokine in defense against mycobacteria, including Bacillus Calmette-Guérin (BCG). Mannose-binding lectin (MBL) and Toll-like receptors (TLRs) are pattern-recognizing molecules of innate immunity. The aim of the present study was to investigate the relationship between polymorphisms in MBL, TLR1, TLR2, and TLR6 encoding genes and stimulated IFN-γ and interleukin-12 (IL-12) ex vivo production in BCG osteitis survivors. METHODS: Data on single nucleotide polymorphisms (SNPs) in the MBL2 gene and TLR1, TLR2, and TLR6 genes were available from 132 former BCG osteitis patients, and data on ex vivo IFN-γ and IL-12 production were available from 115 and 118 patients, respectively...
October 17, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27754824/mutation-in-the-l3-ribosomal-protein-could-be-associated-with-risk-of-selection-of-high-level-linezolid-resistant-staphylococcus-epidermidis-strains
#14
Caroline Rouard, Elisabeth Aslangul, Alexandre Rivière, Claire Deback, Marie-José Butel, Florence Doucet-Populaire, Nadège Bourgeois-Nicolaos
Linezolid (LZD) has arisen as an alternative treatment in diabetic foot osteitis due to staphylococci. LZD resistance selection is difficult and involved various molecular mechanisms. As a better knowledge of those mechanisms could be beneficial for pathogenic strains' screening, we simulated in vitro the spontaneous mutagenesis process that leads to LZD-resistant strains from two Staphylococcus epidermidis strains responsible for monomicrobial diabetic foot osteitis. LZD high resistance was selected for both strains, with the same timeline of mutation appearance...
October 18, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27752206/comparative-evaluation-of-er-cr-ysgg-diode-laser-and-alvogyl-in-the-management-of-alveolar-osteitis-a-prospective-randomized-clinical-study
#15
Amita Rani, Sujata Mohanty, Pankaj Sharma, Jitender Dabas
INTRODUCTION: Alveolar osteitis (AO) is a well-known complication following tooth extraction. Plethora of literature is available regarding its treatment modalities signifying that none of the treatment is as effective as any another treatment. LASER on the other hand, has been used to promote soft tissue healing. MATERIAL AND METHOD: In order to evaluate the effects of laser on healing of AO we undertook a randomized clinical trial. In the trial, sixty patients diagnosed with AO were randomly divided into three groups viz: alvogyl, diode laser and Er:Cr:YSGG laser (erbium chromium yttrium scandium gallium garnet)...
September 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27742022/imaging-for-synovitis-acne-pustulosis-hyperostosis-and-osteitis-sapho-syndrome
#16
Steven Schaub, Hartley M Sirkis, Jonathan Kay
Multifocal osteomyelitis and synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome constitute a spectrum of disease that includes inflammatory bone lesions and dermatologic findings. Radiographic features resemble those of the spondyloarthropathies with anterior chest wall involvement. Early radiographic findings are osteodestructive with lytic lesions. Bone scintigraphy of the sternoclavicular region classically yields a 'bull's head' pattern of radionuclide uptake. Magnetic resonance imaging (MRI) can demonstrate corner lesions of vertebral bodies...
November 2016: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/27730042/sapho-syndrome-with-acne-fulminans-and-severe-polyosteitis-involving-axial-skeleton
#17
B Lakshmi Divya, P Narasimha Rao
SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis), a rare inflammatory disorder, is an association of distinct skin disorders with pustules with osteoarticular inflammation. Its etiology remains unclear, and various treatment regimens frequently fail to control the disease. An 18-year-old male patient presented to the outpatient department with severe nodulocystic acne on the face with pain at both the wrists and lower back associated with high-grade fever and chills. On physical examination, he had severe tenderness at both wrist joints and lower back, along with swelling of right wrist...
September 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27708951/characteristics-and-outcomes-of-chronic-non-bacterial-osteitis-in-children
#18
Stefanie Wintrich, Gerd Horneff
OBJECTIVE: To determine patient characteristics, clinical presentation, pattern of involvement, treatment, and outcome of patients with chronic non-bacterial osteitis (CNO). MATERIAL AND METHODS: Consecutive cases of CNO were analyzed at a single center for pediatrics and adolescent medicine from 2006 to 2013 in terms of patient characteristics, clinical presentation, pattern of involvement, treatment, and outcome. RESULTS: We identified 32 children aged 1...
December 2015: European Journal of Rheumatology
https://www.readbyqxmd.com/read/27698770/multimodal-imaging-findings-of-sapho-syndrome-with-no-skin-lesions-a-report-of-three-cases-and-review-of-the-literature
#19
Na Duan, Xiao Chen, Yongkang Liu, Jianhua Wang, Zhongqiu Wang
Synovitis, acne, palmoplantar pustulosis, hyperostosis and osteitis syndrome (SAPHO) is a rare syndrome that affects the skin, bones and joints. Diagnosis of SAPHO syndrome is established on clinical appearance and imaging features. The present case report described the imaging features of three cases of SAPHO with sternoclavicular joint arthritis but without skin manifestations using multiple imaging modalities, including computed tomography (CT), magnetic resonance imaging (MRI) and bone scintigraphy. The first case was a 52-year-old male who suffered from progressive sternoclavicular arthritis for 2 years...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27676858/guidelines-from-perse-and-sofmer-for-neurological-pressure-ulcer-medical-and-surgical-coverage
#20
Brigitte Barrois, Brigitte Perrouin-Verbe, Xavier De-Boissezon, Djamel Ben Smail, Dominique Casanova, Anthony Gelis, Denis Colin
Surgical indication is recommended for specific locations (pelvic stage 3 and 4 pressure ulcers) and if medical treatment is impossible: - global patient assessment is recommended before surgical indication with benefits and risks analysis; - analysis is conducted on several stages; - risk factors analysis and control level; - efficiency analysis about medical and preventive coverage; - pressure ulcer origin analysis; - compliance patient assessment (care contract); - systematic pre operative procedure is recommended: - multi-disciplinary et pluriprofessionnal consultation; - psychological assessment and follow up; - radiological assessment (systematical, no systematical IRM except if osteitis, no TDM, no scintigraphy); - biological assessment (inflammatory nutritional, micro biological); - no pre-operative antibiotherapy; - specify definition of surgical type - realize pre-operative micro biological taking is recommended:(according to bone aspect): - enforce systematic post operative procedures is recommended: - plan patient installation: every patient must have a preventive mattress and book curative mattress for multiple scrap; - plan total immediate post operative dumped according to patient compliance in PRM ward (during at least 3 weeks, often 4); - organize seated station progressive recharging in PRM ward (during at least 3 weeks); - extend patient supervision and allow seated station; - plan further supervision...
September 2016: Annals of Physical and Rehabilitation Medicine
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