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https://www.readbyqxmd.com/read/28531339/limtox-a-web-tool-for-applied-text-mining-of-adverse-event-and-toxicity-associations-of-compounds-drugs-and-genes
#1
Andres Cañada, Salvador Capella-Gutierrez, Obdulia Rabal, Julen Oyarzabal, Alfonso Valencia, Martin Krallinger
A considerable effort has been devoted to retrieve systematically information for genes and proteins as well as relationships between them. Despite the importance of chemical compounds and drugs as a central bio-entity in pharmacological and biological research, only a limited number of freely available chemical text-mining/search engine technologies are currently accessible. Here we present LimTox (Literature Mining for Toxicology), a web-based online biomedical search tool with special focus on adverse hepatobiliary reactions...
May 22, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28530006/kindergarten-elementary-school-teachers-and-web-based-oral-health-related-resources-an-exploration
#2
Marita Rohr Inglehart, Gabrielle A Zuzo, Joshua J Wilson
PURPOSE: The percentage of U.S. children with poor oral health continues to be high. Kindergarten/elementary school educators could play an important role in teaching students about oral health promotion. The objectives were to assess which oral health-related web-based resources teachers consider most helpful and how teachers' attitudes, knowledge, and behavioural intentions concerning oral health-related teaching change between before and after having access to a resource website. MATERIALS AND METHODS: Web-based survey data were collected from 95 kindergarten/elementary school educators before and after they accessed a website with oral health-related information for teachers (web-link: http://media...
May 19, 2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28529706/expresso-a-database-and-web-server-for-exploring-the-interaction-of-transcription-factors-and-their-target-genes-in-arabidopsis-thaliana-using-chip-seq-peak-data
#3
Delasa Aghamirzaie, Karthik Raja Velmurugan, Shuchi Wu, Doaa Altarawy, Lenwood S Heath, Ruth Grene
Motivation: The increasing availability of chromatin immunoprecipitation sequencing (ChIP-Seq) data enables us to learn more about the action of transcription factors in the regulation of gene expression. Even though in vivo transcriptional regulation often involves the concerted action of more than one transcription factor, the format of each individual ChIP-Seq dataset usually represents the action of a single transcription factor. Therefore, a relational database in which available ChIP-Seq datasets are curated is essential...
2017: F1000Research
https://www.readbyqxmd.com/read/28528939/aga-white-paper-training-and-implementation-of-endoscopic-image-enhancement-technologies
#4
Neil Gupta, Joel V Brill, Marcia Canto, Daniel DeMarco, Brian M Fennerty, Loren Laine, David Lieberman, Charles Lightdale, Elizabeth Montgomery, Robert Odze, Douglas Rex, Prateek Sharma, Jeffrey L Tokar, Michael L Kochman
Endoscopic image-enhancement technologies provide opportunities to visualize normal and abnormal tissues within the gastrointestinal (GI) tract in a manner that complements conventional white light endoscopic imaging. The additional information that is obtained enables the endoscopist to better identify, delineate, and characterize lesions and can facilitate targeted biopsies or, in some cases, eliminate the need to send samples for histologic analysis. Some of these technologies have been available for more than a decade, but despite this fact, there is limited use of these technologies by endoscopists...
June 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28526674/development-of-a-web-based-health-care-intervention-for-patients-with-heart-disease-lessons-learned-from-a-participatory-design-study
#5
Birgitte Noergaard, Marianne Sandvei, Nina Rottmann, Helle Johannessen, Uffe Wiil, Thomas Schmidt, Susanne S Pedersen
BACKGROUND: The use of telemedicine technologies in health care has increased substantially, together with a growing interest in participatory design methods when developing telemedicine approaches. OBJECTIVE: We present lessons learned from a case study involving patients with heart disease and health care professionals in the development of a personalized Web-based health care intervention. METHODS: We used a participatory design approach inspired by the method for feasibility studies in software development...
May 17, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28525568/scenery-a-web-application-for-causal-network-reconstruction-from-cytometry-data
#6
Georgios Papoutsoglou, Giorgos Athineou, Vincenzo Lagani, Iordanis Xanthopoulos, Angelika Schmidt, Szabolcs Éliás, Jesper Tegnér, Ioannis Tsamardinos
Flow and mass cytometry technologies can probe proteins as biological markers in thousands of individual cells simultaneously, providing unprecedented opportunities for reconstructing networks of protein interactions through machine learning algorithms. The network reconstruction (NR) problem has been well-studied by the machine learning community. However, the potentials of available methods remain largely unknown to the cytometry community, mainly due to their intrinsic complexity and the lack of comprehensive, powerful and easy-to-use NR software implementations specific for cytometry data...
May 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28522849/carcinopred-el-novel-models-for-predicting-the-carcinogenicity-of-chemicals-using-molecular-fingerprints-and-ensemble-learning-methods
#7
Li Zhang, Haixin Ai, Wen Chen, Zimo Yin, Huan Hu, Junfeng Zhu, Jian Zhao, Qi Zhao, Hongsheng Liu
Carcinogenicity refers to a highly toxic end point of certain chemicals, and has become an important issue in the drug development process. In this study, three novel ensemble classification models, namely Ensemble SVM, Ensemble RF, and Ensemble XGBoost, were developed to predict carcinogenicity of chemicals using seven types of molecular fingerprints and three machine learning methods based on a dataset containing 1003 diverse compounds with rat carcinogenicity. Among these three models, Ensemble XGBoost is found to be the best, giving an average accuracy of 70...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28521065/eelab-an-innovative-educational-resource-in-occupational-medicine
#8
A Y Zhou, J Dodman, L Hussey, D Sen, C Rayner, N Zarin, R Agius
Background: Postgraduate education, training and clinical governance in occupational medicine (OM) require easily accessible yet rigorous, research and evidence-based tools based on actual clinical practice. Aims: To develop and evaluate an online resource helping physicians develop their OM skills using their own cases of work-related ill-health (WRIH). Methods: WRIH data reported by general practitioners (GPs) to The Health and Occupation Research (THOR) network were used to identify common OM clinical problems, their reported causes and management...
May 17, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28515699/active-involvement-of-end-users-when-developing-web-based-mental-health-interventions
#9
Derek de Beurs, Inge van Bruinessen, Janneke Noordman, Roland Friele, Sandra van Dulmen
BACKGROUND: Although many web-based mental health interventions are being released, the actual uptake by end users is limited. The marginal level of engagement of end users when developing these interventions is recognized as an important cause for uptake problems. In this paper, we offer our perceptive on how to improve user engagement. By doing so, we aim to stimulate a discourse on user involvement within the field of online mental health interventions. METHODS: We shortly describe three different methods (the expert-driven method, intervention mapping, and scrum) that were currently used to develop web-based health interventions...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28511085/development-implementation-and-effects-of-an-integrated-web-based-teaching-model-in-a-nursing-ethics-course
#10
S-Y Chao, Y-C Chang, S C Yang, M J Clark
BACKGROUND: Ethical competence, which is reflected in the ability to detect ethical challenges in clinical situations and engage in deliberate thinking on ethical actions, is one of the core competencies of nursing practice. PURPOSE: The purpose of this study was to develop and implement an interactive situational e-learning system, integrating nursing ethical decisions into a nursing ethics course, and to evaluate the effects of this course on student nurses' ethical decision-making competence...
April 19, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28510500/using-big-data-to-guide-implementation-of-a-web-and-mobile-adaptive-learning-platform-for-medical-students
#11
Ashwin Menon, Shiv Gaglani, M Ryan Haynes, Sean Tackett
BACKGROUND: Adaptive learning platforms (ALPs) can revolutionize medical education by making learning more efficient, but their potential has not been realized because students do not use them persistently. METHODS: We applied educational data mining methods to study United States medical students who used an ALP called Osmosis ( www.osmosis.org ) from 1 August 2014 to 31 July 2015. Multivariate logistic regressions modeled persistence on Osmosis as the dependent variable and Osmosis-collected variables as predictors...
May 16, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28508804/ehealth-networking-information-systems-the-new-quality-of-information-exchange
#12
Karin Messer-Misak, Christoph Reiter
BACKGROUND: The development and introduction of platforms that enable interdisciplinary exchange on current developments and projects in the area of eHealth have been stimulated by different authorities. OBJECTIVES: The aim of this project was to develop a repository of eHealth projects that will make the wealth of eHealth projects visible and enable mutual learning through the sharing of experiences and good practice. METHODS: The content of the database and search criteria as well as their categories were determined in close co-ordination and cooperation with stakeholders from the specialist areas...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28506959/health-related-internet-use-in-people-with-cancer-results-from-a-cross-sectional-study-in-two-outpatient-clinics-in-sweden
#13
Susanne Mattsson, Erik Martin Gustaf Olsson, Birgitta Johansson, Maria Carlsson
BACKGROUND: The access to various forms of support during the disease trajectory is crucial for people with cancer. The provision and use of Internet health services is increasing, and it is important to further investigate the preferences and demographical characteristics of its users. Investigating the uptake and perceived value of Internet health services is a prerequisite to be able to meet the needs in the targeted group. OBJECTIVE: The objective of this study was to investigate health-related Internet use among people with cancer...
May 15, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28503375/network-science-meets-respiratory-medicine-for-osas-phenotyping-and-severity-prediction
#14
Stefan Mihaicuta, Mihai Udrescu, Alexandru Topirceanu, Lucretia Udrescu
Obstructive sleep apnea syndrome (OSAS) is a common clinical condition. The way that OSAS risk factors associate and converge is not a random process. As such, defining OSAS phenotypes fosters personalized patient management and population screening. In this paper, we present a network-based observational, retrospective study on a cohort of 1,371 consecutive OSAS patients and 611 non-OSAS control patients in order to explore the risk factor associations and their correlation with OSAS comorbidities. To this end, we construct the Apnea Patients Network (APN) using patient compatibility relationships according to six objective parameters: age, gender, body mass index (BMI), blood pressure (BP), neck circumference (NC) and the Epworth sleepiness score (ESS)...
2017: PeerJ
https://www.readbyqxmd.com/read/28503310/individual-capacity-building-approaches-in-a-global-pharmaceutical-systems-strengthening-program-a-selected-review
#15
Niranjan Konduri, Megan Rauscher, Shiou-Chu Judy Wang, Tanya Malpica-Llanos
BACKGROUND: Medicines use related challenges such as inadequate adherence, high levels of antimicrobial resistance and preventable adverse drug reactions have underscored the need to incorporate pharmaceutical services to help achieve desired treatment outcomes, and protect patients from inappropriate use of medicines. This situation is further constrained by insufficient numbers of pharmaceutical personnel and inappropriate skill mix. Studies have addressed individual capacity building approaches of logistics, supply chain or disease specific interventions but few have documented those involving such pharmacy assistants/professionals, or health workers/professionals charged with improving access and provision of pharmaceutical services...
2017: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/28495347/a-web-based-clinical-decision-support-system-for-gestational-diabetes-automatic-diet-prescription-and-detection-of-insulin-needs
#16
Estefanía Caballero-Ruiz, Gema García-Sáez, Mercedes Rigla, María Villaplana, Belen Pons, M Elena Hernando
BACKGROUND: The growth of diabetes prevalence is causing an increasing demand in health care services which affects the clinicians' workload as medical resources do not grow at the same rate as the diabetic population. Decision support tools can help clinicians with the inspection of monitoring data, providing a preliminary analysis to ease their interpretation and reduce the evaluation time per patient. This paper presents Sinedie, a clinical decision support system designed to manage the treatment of patients with gestational diabetes...
June 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28495339/user-experience-analysis-of-an-ehealth-system-for-tuberculosis-in-resource-constrained-settings-a-nine-country-comparison
#17
Niranjan Konduri, L Gustavo V Bastos, Kelly Sawyer, L Fernando A Reciolino
BACKGROUND: e-TB Manager, a web-based eHealth system has been successfully institutionalized in 10 resource-constrained countries that account for one-third of the world's tuberculosis (TB) burden, but user experience has never been evaluated. METHODS: A cross-sectional, anonymous survey in eight unique languages based on the targeted countries. e-TB Manager users included nurses, doctors, pharmacists, statisticians/data officers, laboratory professionals/assistants, health workers, and administrators...
June 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28493616/descriptive-title-impact-of-a-webcast-on-nurses-delivery-of-tobacco-dependence-treatment
#18
Linda Sarna, Stella Aguinaga Bialous, Marjorie Wells, Jenny Brook
AIMS AND OBJECTIVES: The aims were to evaluate an educational program about nurses' role in tobacco dependence treatment, and its webcast component, on the long-term impact of increasing the frequency of nurses' self-reported changes in practice related to delivery of smoking cessation interventions. BACKGROUND: Healthcare professionals' knowledge about evidence-based tobacco dependence treatment using the 5As framework (Ask about tobacco use, Advise users to quit, Assess willingness to quit, Assist in making a quit plan, and Arrange for follow-up, including referral to a quitline) is essential to increase smoking cessation rates in the United States...
May 11, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28486511/open-sharing-of-genomic-data-who-does-it-and-why
#19
Tobias Haeusermann, Bastian Greshake, Alessandro Blasimme, Darja Irdam, Martin Richards, Effy Vayena
We explored the characteristics and motivations of people who, having obtained their genetic or genomic data from Direct-To-Consumer genetic testing (DTC-GT) companies, voluntarily decide to share them on the publicly accessible web platform openSNP. The study is the first attempt to describe open data sharing activities undertaken by individuals without institutional oversight. In the paper we provide a detailed overview of the distribution of the demographic characteristics and motivations of people engaged in genetic or genomic open data sharing...
2017: PloS One
https://www.readbyqxmd.com/read/28485102/a-web-based-peer-feedback-tool-for-physical-examination
#20
Ryan Luther, Lisa Richardson
BACKGROUND: Medical students do not have many formal opportunities to practise physical examinations during their pre-clerkship years. Consequently, they often practise their examination skills with peers outside of formal teaching sessions. There are also few opportunities for observation and feedback on their skills in this area. CONTEXT: The undergraduate medical programme at the University of Toronto is a 4-year programme where students learn clinical skills in the first 2 years prior to beginning clinical rotations...
May 9, 2017: Clinical Teacher
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