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https://www.readbyqxmd.com/read/29792074/lessons-learned-conducting-a-multi-center-trial-with-a-military-population-the-tinnitus-retraining-therapy-trial
#1
Roberta W Scherer, Leonora D Sensinger, Benigno Sierra-Irizarry, Craig Formby
Background The Tinnitus Retraining Therapy Trial (TRTT), a randomized, placebo-controlled, multi-center trial, evaluated the efficacy of tinnitus retraining therapy and its individual components, tinnitus-specific educational counseling and sound therapy versus the standard of care, in military practice to improve study participants' quality of life. The trial was conducted at six US military hospitals to take advantage of the greater prevalence of tinnitus in the military population. Methods During the trial, various challenges arose that were uniquely related to the military setting...
May 1, 2018: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/29792036/meeting-the-challenge-for-effective-antimicrobial-stewardship-programs-in-regional-rural-and-remote-hospitals-what-can-we-learn-from-the-published-literature
#2
Jaclyn Bishop, David Cm Kong, Thomas R Schulz, Karin A Thursky, Kirsty L Buising
INTRODUCTION: Antimicrobial resistance (AMR) has been recognised as an urgent health priority, both nationally and internationally. Australian hospitals are required to have an antimicrobial stewardship (AMS) program, yet the necessary resources may not be available in regional, rural or remote hospitals. This review will describe models for AMS programs that have been introduced in regional, rural or remote hospitals internationally and showcase achievements and key considerations that may guide Australian hospitals in establishing or sustaining AMS programs in the regional, rural or remote hospital setting...
May 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29791275/effects-of-web-based-instruction-and-patient-preferences-on-patient-reported-outcomes-and-learning-for-women-with-advanced-ovarian-cancer-a-randomized-controlled-trial
#3
Sue V Petzel, Rachel Isaksson Vogel, Julie Cragg, Molly McClellan, Daniel Chan, Julie A Jacko, François Sainfort, Melissa A Geller
A randomized controlled trial was conducted of a web-based intervention to improve advanced care planning in women with ovarian cancer. A secondary analysis of 35 randomized women focused on changes in distress and knowledge about ovarian cancer through distress monitoring and information tailored to patients' cognitive coping style (monitoring, blunting). Pre-/postresults indicated the Intervention group demonstrated lower distress (p = 0.06); blunting was associated with lower depression (p = 0.04); knowledge in both groups was unchanged...
May 23, 2018: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/29790960/complexcontact-a-web-server-for-inter-protein-contact-prediction-using-deep-learning
#4
Hong Zeng, Sheng Wang, Tianming Zhou, Feifeng Zhao, Xiufeng Li, Qing Wu, Jinbo Xu
ComplexContact (http://raptorx2.uchicago.edu/ComplexContact/) is a web server for sequence-based interfacial residue-residue contact prediction of a putative protein complex. Interfacial residue-residue contacts are critical for understanding how proteins form complex and interact at residue level. When receiving a pair of protein sequences, ComplexContact first searches for their sequence homologs and builds two paired multiple sequence alignments (MSA), then it applies co-evolution analysis and a CASP-winning deep learning (DL) method to predict interfacial contacts from paired MSAs and visualizes the prediction as an image...
May 22, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29789278/the-effectiveness-of-a-computer-tailored-e-learning-program-for-practice-nurses-to-improve-their-adherence-to-smoking-cessation-counseling-guidelines-randomized-controlled-trial
#5
Dennis de Ruijter, Math Candel, Eline Suzanne Smit, Hein de Vries, Ciska Hoving
BACKGROUND: Improving practice nurses' (PN) adherence to smoking cessation counseling guidelines will benefit the quality of smoking cessation care and will potentially lead to higher smoking abstinence rates. However, support programs to aid PNs in improving their guideline uptake and adherence do not exist yet. OBJECTIVE: The aim of this study was to assess the effects of a novel computer-tailored electronic learning (e-learning) program on PNs' smoking cessation guideline adherence...
May 22, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29788510/predicting-drug-induced-liver-injury-using-ensemble-learning-methods-and-molecular-fingerprints
#6
Haixin Ai, Wen Chen, Li Zhang, Liangchao Huang, Zimo Yin, Huan Hu, Qi Zhao, Jian Zhao, Hongsheng Liu
Drug-induced liver injury (DILI) is a major safety concern in the drug-development process, and various methods have been proposed to predict the hepatotoxicity of compounds during the early stages of drug trials. In this study, we developed an ensemble model using three machine learning algorithms and 12 molecular fingerprints from a dataset containing 1,241 diverse compounds. The ensemble model achieved an average accuracy of 71.1±2.6%, sensitivity of 79.9±3.6%, specificity of 60.3±4.8%, and area under the receiver operating characteristic curve (AUC) of 0...
May 21, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29788456/kinact-a-computational-approach-for-predicting-activating-missense-mutations-in-protein-kinases
#7
Carlos H M Rodrigues, David B Ascher, Douglas E V Pires
Protein phosphorylation is tightly regulated due to its vital role in many cellular processes. While gain of function mutations leading to constitutive activation of protein kinases are known to be driver events of many cancers, the identification of these mutations has proven challenging. Here we present Kinact, a novel machine learning approach for predicting kinase activating missense mutations using information from sequence and structure. By adapting our graph-based signatures, Kinact represents both structural and sequence information, which are used as evidence to train predictive models...
May 21, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29788413/eztag-tagging-biomedical-concepts-via-interactive-learning
#8
Dongseop Kwon, Sun Kim, Chih-Hsuan Wei, Robert Leaman, Zhiyong Lu
Recently, advanced text-mining techniques have been shown to speed up manual data curation by providing human annotators with automated pre-annotations generated by rules or machine learning models. Due to the limited training data available, however, current annotation systems primarily focus only on common concept types such as genes or diseases. To support annotating a wide variety of biological concepts with or without pre-existing training data, we developed ezTag, a web-based annotation tool that allows curators to perform annotation and provide training data with humans in the loop...
May 18, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29788273/the-patient-safety-culture-a-systematic-review-by-characteristics-of-hospital-survey-on-patient-safety-culture-dimensions
#9
Cláudia Tartaglia Reis, Sofia Guerra Paiva, Paulo Sousa
Purpose: To learn the weaknesses and strengths of safety culture as expressed by the dimensions measured by the Hospital Survey on Patient Safety Culture (HSOPSC) at hospitals in the various cultural contexts. The aim of this study was to identify studies that have used the HSOPSC to collect data on safety culture at hospitals; to survey their findings in the safety culture dimensions and possible contributions to improving the quality and safety of hospital care. Data sources: Medline (via PubMed), Web of Science and Scopus were searched from 2005 to July 2016 in English, Portuguese and Spanish...
May 8, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29784634/evaluation-of-app-based-serious-gaming-as-a-training-method-in-teaching-chest-tube-insertion-to-medical-students-randomized-controlled-trial
#10
Patrick Haubruck, Felix Nickel, Julian Ober, Tilman Walker, Christian Bergdolt, Mirco Friedrich, Beat Peter Müller-Stich, Franziska Forchheim, Christian Fischer, Gerhard Schmidmaier, Michael C Tanner
BACKGROUND: The insertion of a chest tube should be as quick and accurate as possible to maximize the benefit and minimize possible complications for the patient. Therefore, comprehensive training and assessment before an emergency situation are essential for proficiency in chest tube insertion. Serious games have become more prevalent in surgical training because they enable students to study and train a procedure independently, and errors made have no effect on patients. However, up-to-date evidence regarding the effect of serious games on performance in procedures in emergency medicine remains scarce...
May 21, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29782521/detecting-trends-in-academic-research-from-a-citation-network-using-network-representation-learning
#11
Kimitaka Asatani, Junichiro Mori, Masanao Ochi, Ichiro Sakata
Several network features and information retrieval methods have been proposed to elucidate the structure of citation networks and to detect important nodes. However, it is difficult to retrieve information related to trends in an academic field and to detect cutting-edge areas from the citation network. In this paper, we propose a novel framework that detects the trend as the growth direction of a citation network using network representation learning(NRL). We presume that the linear growth of citation network in latent space obtained by NRL is the result of the iterative edge additional process of a citation network...
2018: PloS One
https://www.readbyqxmd.com/read/29776902/an-internet-based-radiology-course-in-medical-school-comparison-of-academic-performance-of-students-on-campus-versus-those-with-absenteeism-due-to-residency-interviews
#12
Andrew George Alexander, Deborah Deas, Paul Eric Lyons
BACKGROUND: Imaging and its optimal use are imperative to the practice of medicine, yet many students don't receive a formal education in radiology. Concurrently, students look for ways to take time away from medical school for residency interviewing. Web-based instruction provides an opportunity to combine these imperatives using online modalities. OBJECTIVE: A largely Web-based course in radiology during the 4th year of medical school was evaluated both for its acceptance to students who needed to be away from campus for interviews, and its effectiveness on a nationally administered standardized test...
May 18, 2018: JMIR Medical Education
https://www.readbyqxmd.com/read/29771997/core-neurological-examination-items-for-neurology-clerks-a-modified-delphi-study-with-a-grass-roots-approach
#13
Chi-Hung Liu, Li-Ling Hsu, Cheng-Ting Hsiao, Suh-Ing Hsieh, Chun-Wei Chang, Elaine Shinwei Huang, Yeu-Jhy Chang
BACKGROUND: With the evolution of treatments for neurological diseases, the contents of core neurological examinations (NEs) for medical students may need to be modified. We aimed to establish a consensus on the core NE items for neurology clerks and compare viewpoints between different groups of panelists. METHODS: First, a pilot group proposed the core contents of NEs for neurology clerks. The proposed core NE items were then subject to a modified web-based Delphi process using the online software "SurveyMonkey"...
2018: PloS One
https://www.readbyqxmd.com/read/29771691/the-relationship-between-the-learning-and-patient-safety-climates-of-clinical-departments-and-residents-patient-safety-behaviors
#14
Milou E W M Silkens, Onyebuchi A Arah, Cordula Wagner, Albert J J A Scherpbier, Maas Jan Heineman, Kiki M J M H Lombarts
PURPOSE: Improving residents' patient safety behavior should be a priority in graduate medical education to ensure the safety of current and future patients. Supportive learning and patient safety climates may foster this behavior. This study examined the extent to which residents' self-reported patient safety behavior can be explained by the learning climate and patient safety climate of their clinical departments. METHOD: The authors collected learning climate data from clinical departments in the Netherlands that used the web-based Dutch Residency Educational Climate Test between September 2015 and October 2016...
May 15, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29765458/analysis-of-web-based-learning-methods-in-emergency-medicine-randomized-controlled-trial
#15
Piotr Leszczyński, Joanna Gotlib, Zbigniew Kopański, Arkadiusz Wejnarski, Stanisław Świeżewski, Robert Gałązkowski
Introduction: In medical education, Web-based learning is increasingly used as a complement to practical classes. The objective of the study was to perform a comparative analysis of three different forms of e-learning course on emergency medicine in terms of an indicator of knowledge growth and students' satisfaction. Material and methods: For the purpose of the study, we developed and implemented a tool in the form of an online course: A - non-animated presentation, B - video, C - interactive video...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29764639/web-based-versus-face-to-face-interprofessional-team-encounters-with-standardized-patients
#16
Kelly A Lempicki, Christine S Holland
BACKGROUND: Challenges exist in developing interprofessional education (IPE) activities including coordinating schedules and obtaining appropriate space for teams to work. Virtual worlds have been explored as a means to overcome some of these challenges. We sought to develop a web-based interprofessional team interaction with a standardized patient (SP), as compared to a face-to-face SP interaction, focusing on the competency area of interprofessional communication. INTERPROFESSIONAL EDUCATION ACTIVITY: Interprofessional teams of students were randomized to complete a web-based or face-to-face SP encounter...
March 2018: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29764633/national-preceptor-development-program-pdp-prototype-the-third-of-a-3-part-series
#17
Craig D Cox, Katrina Mulherin, Sheila Walter
INTRODUCTION: Preceptor development is critical to successful delivery of experiential learning. Although many preceptor development programs exist, a more individualized approach to training is needed. To accomplish this a national preceptor development program should be considered based on the continuing professional development model. A detailed prototype for this program has been described. METHODS: In this final installment of the series, the twelve evidence-based recommendations from the first installment were utilized to construct a prototype for a preceptor development program...
March 2018: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29764175/caring-communities-as-collective-learning-process-findings-and-lessons-learned-from-a-participatory-research-project-in-austria
#18
Klaus Wegleitner, Patrick Schuchter
BACKGROUND: By now, the public health end-of-life care approach is well established and has induced diverse initiatives-subsumed under the concept of compassionate or caring communities-to engage the community in supporting vulnerable, dying people and their beloved ones. In the light of a participatory research project our paper examines the question: what are the deeper ideas behind caring communities and what constitutes a caring community? METHODS: A multi-level analysis based on (I) qualitative research with focus groups and interviews with community members within the project; (II) the reflection of the role of participatory research in caring community initiatives, and (III) the meta-analysis of an international expert workshop, which allowed to discuss our experiences and insights in the light of international caring community models and expertise...
April 2018: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29760581/educational-program-for-middle-level-public-health-nurses-to-develop-new-health-services-regarding-community-health-needs-protocol-for-a-randomized-controlled-trial
#19
Kyoko Yoshioka-Maeda, Takafumi Katayama, Misa Shiomi, Noriko Hosoya
Background: Developing health services is a key strategy for improving the community health provided by public health nurses. However, an effective educational program for improving their skills in planning such services has not been developed. To describe our program and its evaluation protocol for the education of middle-level public health nurses to improve their skills in developing new health services to fulfil community health needs in Japan. Methods: In this randomized control trial, eligible participants in Japan will be randomly allocated to an intervention group and a control wait-list group...
2018: BMC Nursing
https://www.readbyqxmd.com/read/29756475/national-survey-of-pediatric-care-providers-assessing-time-and-impact-of-coding-and-documentation-in-physician-practice
#20
Anshul Arora, Ashish Garg, Vrinda Arora, Munaza Rizvi, Ninad Desai
BACKGROUND: Documentation and billing/coding are essential to medical practice. Physicians spend significant time documenting to meet coding and medicolegal requirements, potentially reducing time for patient care and learning. We sought to assess time spent charting in pediatric practice and provider understanding and comfort level regarding billing/coding. METHODS: An anonymous web-based survey was emailed to members of American Academy of Pediatrics Section of Pediatric Trainees practicing in the United States...
May 1, 2018: Clinical Pediatrics
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