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STEMI elderly

Alessandra M Campos, Andrea Placido-Sposito, Wladimir M Freitas, Filipe A Moura, Maria Elena Guariento, Wilson Nadruz, Emilio H Moriguchi, Andrei C Sposito
BACKGROUND: Despite the high incidence and mortality of ST-segment elevation myocardial infarction (STEMI) among the very elderly, risk markers for this condition remain poorly defined. This study was designed to identify independent markers of STEMI among individuals carefully selected for being healthy or manifesting STEMI in < 24 h. METHODS: We enrolled participants aged 80 years or older of whom 50 were STEMI patients and 207 had never manifested cardiovascular diseases...
December 2016: BBA Clinical
Erru Yang, Michael Stokes, Saga Johansson, Carl Mellström, Elizabeth Magnuson, David J Cohen, Phillip Hunt
OBJECTIVES: Longitudinal data are limited regarding outcomes and costs beyond one year after acute myocardial infarction (MI) among elderly (≥65 years old) United States patients. This study examined long-term outcomes and healthcare costs among elderly MI survivors. METHODS: .Retrospective analysis of 2002-2009 Medicare healthcare claims (5% random sample). Patients were ≥65 years old and survived ≥1 year without recurrent MI after MI hospitalization. Mortality, incidence of hospitalizations for stroke, major bleeding, MI, a composite endpoint (death, MI or stroke), and non-pharmacy healthcare costs were determined...
August 26, 2016: Cardiovascular Therapeutics
Maria Dorobantu, Stefan Bogdan
With the ageing of the general population, clinicians are facing with increased frequency the challenge of administering parenteral anti-coagulation therapy in the elderly, the main indications being venous thromboembolism (VTE), acute coronary syndromes (ACS), atrial fibrillation and bridging therapy. Assessing the risk/benefit ratio is always difficult in this category of patients, because of the higher risk for hemorrhagic events, although in most cases the benefit outweighs the risk, especially in the setting of VTE...
November 1, 2016: International Journal of Cardiology
J F Argacha, P Collart, A Wauters, P Kayaert, S Lochy, D Schoors, J Sonck, T de Vos, M Forton, O Brasseur, C Beauloye, S Gevaert, P Evrard, Y Coppieters, P Sinnaeve, M J Claeys
BACKGROUND: Previous studies have shown that air pollution particulate matter (PM) is associated with an increased risk for myocardial infarction. The effects of air pollution on the risk of ST-elevation myocardial infarction (STEMI), in particular the role of gaseous air pollutants such as NO2 and O3 and the susceptibility of specific populations, are still under debate. METHODS: All patients entered in the Belgian prospective STEMI registry between 2009 and 2013 were included...
November 15, 2016: International Journal of Cardiology
Beatrice Ricci, Olivia Manfrini, Edina Cenko, Zorana Vasiljevic, Maria Dorobantu, Sasko Kedev, Goran Davidovic, Marija Zdravkovic, Olivija Gustiene, Božidarka Knežević, Davor Miličić, Lina Badimon, Raffaele Bugiardini
BACKGROUND: Limited data are available on the outcome of primary percutaneous coronary intervention (PCI) in octogenarian patients, as the elderly are under-represented in randomized trials. This study aims to provide insights on clinical characteristics, management and outcome of the elderly and very elderly presenting with STEMI. METHODS: 2225 STEMI patients ≥70years old (mean age 76.8±5.1years and 53.8% men) were admitted into the network of the ISACS-TC registry...
November 1, 2016: International Journal of Cardiology
Edina Cenko, Beatrice Ricci, Sasko Kedev, Oliver Kalpak, Lucian Câlmâc, Zorana Vasiljevic, Božidarka Knežević, Mirza Dilic, Davor Miličić, Olivia Manfrini, Akos Koller, Maria Dorobantu, Lina Badimon, Raffaele Bugiardini
BACKGROUND: The objectives of this study were to evaluate the incidence of no-reflow as independent predictor of adverse events and to assess whether baseline pre-procedural treatment options may affect clinical outcomes. METHODS: Data were derived from the ISACS-TC registry (NCT01218776) from October 2010 to January 2015. No-reflow was defined as post-PCI TIMI flow grades 0-1, in the absence of post-procedural significant (≥25%) residual stenosis, abrupt vessel closure, dissection, perforation, thrombus of the original target lesion, or epicardial spasm...
November 1, 2016: International Journal of Cardiology
Yu-Chen Wang, Ying-Ying Huang, Ping-Hang Lo, Kuan-Cheng Chang, Chu-Huang Chen, Ming-Fong Chen
BACKGROUND: To investigate the age-dependent impact of the superfast door-to-balloon (D2B) times of ≤60min as recommended by the new ESC Guideline for patients with ST elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) on mid-term survival rates based on a single center registry dataset. PATIENTS AND METHODS: This study enrolled consecutive STEMI patients who underwent PPCI from Jan 1, 2009 through Sep 30, 2013...
November 1, 2016: International Journal of Cardiology
Giuseppina Basta, Kyriazoula Chatzianagnostou, Umberto Paradossi, Nicoletta Botto, Serena Del Turco, Alessandro Taddei, Sergio Berti, Annamaria Mazzone
BACKGROUND: The prognostic impact of nutritional status in ST-elevation myocardial infarction (STEMI) patients is poorly understood. METHODS: We used the controlling nutritional status (CONUT) score and the prognostic nutritional index (PNI) score on outcomes of 945 patients with acute STEMI undergoing primary percutaneous coronary intervention with stent. RESULTS: During a median follow-up of 2years (1-3.3years, interquartile range), 56 patients (5...
October 15, 2016: International Journal of Cardiology
Juan Sanchis, Eduardo Núñez, José Antonio Barrabés, Francisco Marín, Luciano Consuegra-Sánchez, Silvia Ventura, Ernesto Valero, Mercè Roqué, Antoni Bayés-Genís, Bruno García Del Blanco, Irene Dégano, Julio Núñez
BACKGROUND: Comorbid elderly patients with non-ST-elevation myocardial infarction (non-STEMI) are underrepresented in randomized trials and undergo fewer cardiac catheterizations according to registries. Our aim was to compare the conservative and invasive strategies in these patients. METHODS: Randomized multicenter study, including 106 patients (January 2012-March 2014) with non-STEMI, over 70years and with comorbidities defined by at least two of the following: peripheral artery disease, cerebral vascular disease, dementia, chronic pulmonary disease, chronic renal failure or anemia...
July 13, 2016: European Journal of Internal Medicine
Zorana Vasiljevic-Pokrajcic, Natasa Mickovski, Goran Davidovic, Milika Asanin, Branislav Stefanovic, Gordana Krljanac, Mina Radosavljevic-Radovanovic, Nebojsa Radovanovic, Ratko Lasica, Sladjan Milanović, Jovana Bjekić, Marta Majstorovic-Stakic, Danijela Trifunovic, Ana Karadzic, Dubravka Rajic, Aleksandra Milosevic, Marija Zdravkovic, Jelena Saric, Raffaele Bugiardini
BACKGROUND: There is conflicting information about sex differences in presentation, treatment, and outcome after acute coronary syndromes (ACS) in the era of reperfusion therapy and percutaneous coronary intervention. The aim of this study was to examine presentation, acute therapy, and outcomes of men and women with ACS with special emphasis on their relationship with younger age (≤65years). METHODS: From January 2010 to June 2015, we enrolled 5140 patients from 3 primary PCI capable hospitals...
August 2016: International Journal of Cardiology
Lucian Câlmâc, Vlad Bătăilă, Beatrice Ricci, Zorana Vasiljevic, Sasko Kedev, Olivija Gustiene, Dijana Trininic, Božidarka Knežević, Davor Miličić, Mirza Dilic, Olivia Manfrini, Edina Cenko, Lina Badimon, Raffaele Bugiardini, Alexandru Scafa-Udriște, Oana Tăutu, Maria Dorobanțu
BACKGROUND: A substantial proportion of elderly with ST segment elevation myocardial infarction (STEMI) do not undergo percutaneous coronary intervention (PCI). We sought to investigate factors associated with the decision not to perform coronary angiography at admission in these patients. METHODS: We evaluated 1315 STEMI patients aged ≥75years old enrolled in the International Survey of Acute Coronary Syndromes in Transitional Countries (ISACS TC) registry between October 2010 and February 2015...
August 2016: International Journal of Cardiology
S Tatishvili, R Jorbenadze, G Kavtaradze
Psychosocial risk factors are known to have a negative impact on coronary disease morbidity and mortality. The aim of our study was to establish contribution of depression on hospital length of stay in patients with acute coronary events. Depression screening was performed in the Chapidze Center, Tbilisi Georgia. Main inclusion criteria in the study were acute coronary events - non-ST elevation myocardial infarction or unstable angina. The total nomber of participants was 84. A binary logistic regression was used in order to assess contribution of depression on prolonged hospital stay...
March 2016: Georgian Medical News
Fereydoon Noohi, Isa Hashemi, Hamid Reza Sanati, Mohammad Mehdi Peighambari, Majid Kiavar, Mohsen Maadani, Hossein Ali Bassiri, Ali Zahedmehr, Farshad Shakerian, Ata Firouzi, Reza Kiani, Seifollah Abdi
BACKGROUND: Elderly patients constitute a rapidly growing proportion of the population, and hence the increasing rises in the number of patients with ST-segment-elevation myocardial infarction (STEMI). Primary percutaneous coronary intervention (PCI), which is now established as the preferred reperfusion strategy in STEMI patients, has been inadequately investigated in this high-risk group. The aim of the present study was to investigate the in-hospital and 6-month outcomes of primary PCI in elderly patients (≥ 75 years) with STEMI...
January 2016: ARYA Atherosclerosis
András Komócsi, Mihály Simon, Béla Merkely, Tibor Szűk, Róbert G Kiss, Dániel Aradi, Zoltán Ruzsa, Péter Andrássy, Lajos Nagy, Géza Lupkovics, Zsolt Kőszegi, Péter Ofner, András Jánosi
BACKGROUND: Data are limited on the real-life use of coronary intervention (PCI) and on its long-term efficacy and safety in elderly patients with acute myocardial infarction (AMI). METHODS: Data from a nation-wide registry of patients treated due to an AMI event in centers of invasive cardiology were analyzed for the potential interaction of age on the utilization of invasive therapy and outcome. Follow-up data of consecutive patients between March 1, 2013, and March 1, 2014 were analyzed...
July 1, 2016: International Journal of Cardiology
Lei Huang, Tong Li, Ying-Wu Liu, Lei Zhang, Zhi-Huan Dong, Shu-Ye Liu, Ying-Tang Gao
BACKGROUND: This study was to establish a disease differentiation model for ST-segment elevation myocardial infarction (STEMI) youth patients experiencing ischemia and reperfusion via ultra-performance liquid chromatography and mass spectrometry (UPLC/MS) platform, which searches for closely related characteristic metabolites and metabolic pathways to evaluate their predictive value in the prognosis after discharge. METHODS: Forty-seven consecutive STEMI patients (23 patients under 45 years of age, referred to here as "youth," and 24 "elderly" patients) and 48 healthy control group members (24 youth, 24 elderly) were registered prospectively...
May 5, 2016: Chinese Medical Journal
Benoit Lattuca, Pascale Fabbro-Peray, Florence Leclercq, Laurent Schmutz, Bertrand Ledermann, Luc Cornillet, Jean-François Benezet, Jean-Christophe Macia, Jean-Emmanuel de La Coussaye, Patrick Messner-Pellenc, Guillaume Cayla
BACKGROUND: Little information is available on the long-term incidence of bleeding events after ST-segment elevation myocardial infarction (STEMI) with the current antithrombotic strategy. AIMS: To evaluate the effect of bleedings for up to 12months on clinical events and therapeutic compliance in unselected STEMI patients treated with prasugrel or clopidogrel. METHODS: Patients were treated with clopidogrel or prasugrel according to guidelines...
May 2016: Archives of Cardiovascular Diseases
R S Tarasov, A M Kochergina, V I Ganyukov, O L Barbarash
AIM: To investigate the impact of the degree of coronary atherosclerosis evaluated by the SYNTAX scale on the early and late results of endovascular revascularization in elderly and middle-aged patients with ST-segment elevation myocardial infarction (STEMI). SUBJECTS AND METHODS: The investigation enrolled 327 consecutively admitted patients with STEMI and multivessel coronary bed disease, who had received revascularization within the first 12 hours after disease onset via primary percutaneous coronary interventions (PCI)...
2016: Terapevticheskiĭ Arkhiv
Fernando Gonzalez, Christophe Marti, Maria Chrysafi, Nicolas Beysard, Olivier Grosgurin, Pierre-Nicolas Carron, Olivier Rutschmann
The year 2015 was marked by several publications questioning the practice of emergency medicine. The systematic administration of oxygen in STEMI patients offers no benefit. Similarly, medical expulsive therapy in patients with ureteric stones was questioned. Administration of steroids for acute radiculopathy showed only short-term, but no mid-term pain improvement. Several studies have demonstrated the benefit combining intraarterial and intravenous thrombolytic therapy for ischemic stroke. However, studies assessing optimal management strategy for patients hospitalized with community acquired pneumonia, showed conflicting results...
January 13, 2016: Revue Médicale Suisse
Andrea Santucci, Giuseppe Gargiulo, Sara Ariotti, Marcello Marino, Giulia Magnani, Andrea Baldo, Raffaele Piccolo, Anna Franzone, Marco Valgimigli
Radial approach has been used since 1989 to perform coronary angiography as an alternative to femoral access. During past decades, the development of dedicated equipment has led to high efficacy also in complex procedures. ST elevation myocardial infarction (STEMI) is known to be a high bleeding risk setting and in turn bleeding events can negatively impact on outcomes. Observational studies have demonstrated feasibility, efficacy and safety of radial approach when compared to femoral access in STEMI patients, with benefit in bleeding rates...
June 2016: Minerva Cardioangiologica
Soe Hee Ann, Cai De Jin, Gillian Balbir Singh, Kyung Hun Lim, Jae-Wook Chung, Scot Garg, Moo Hyun Kim, Wang-Soo Lee, Kyoung Im Cho, Sang Wook Kim, Eun-Seok Shin
There is limited research on plaque characteristics of ST elevation myocardial infarction (STEMI) patients according to the gender and age. 280 Consecutive STEMI patients who underwent VH-IVUS imaging on culprit before percutaneous coronary intervention (PCI) were enrolled in this study. Women were significantly older than men (69.8 ± 10 vs. 55.9 ± 11.3, p < 0.001). After propensity matching, men had higher plaque burden (79.7 ± 7.8 vs. 73.7 ± 13.0 %, p = 0.010), more fibro-fatty tissue (12...
February 13, 2016: Heart and Vessels
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