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https://www.readbyqxmd.com/read/29793094/effects-of-chronic-antipsychotic-drug-exposure-on-the-expression-of-translocator-protein-and-inflammatory-markers-in-rat-adipose-tissue
#1
Anita Calevro, Marie-Caroline Cotel, Sridhar Natesan, Michel Modo, Anthony C Vernon, Valeria Mondelli
The precise effect of antipsychotic drugs on either central or peripheral inflammation remains unclear. An important issue in this debate is to what extent the known peripheral metabolic effects of antipsychotics, including increased adiposity, may contribute to increased inflammation. Adipose tissue is known to contribute to the development of systemic inflammation, which can eventually lead to insulin resistance and metabolic dysregulation. As a first step to address this question, we evaluated whether chronic exposure to clinically comparable doses of haloperidol or olanzapine resulted in the immune activation of rat adipose tissue...
May 16, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29793067/performance-and-methane-fermentation-characteristics-of-a-pilot-scale-anaerobic-membrane-bioreactor-anmbr-for-treating-pharmaceutical-wastewater-containing-m-cresol-mc-and-iso-propyl-alcohol-ipa
#2
Zhaobo Chen, Xue Li, Dongxue Hu, Yubo Cui, Fuguang Gu, Fuquan Jia, Tingting Xiao, Haiyan Su, Jiao Xu, Haixu Wang, Pan Wu, Ying Zhang, Na Jiang
In this study, a pilot scale anaerobic membrane bioreactor (AnMBR) was operated for 80 days to treat pharmaceutical wastewater containing m-cresol (MC) and iso-propyl alcohol (IPA). The aim of the study is to investigate the performance and methane fermentation characteristics of AnMBR at different hydraulic retention time (HRT) (48, 36, 24, 18 and 12 h). The average total removal efficiencies of MC and IPA were 95%, 96% during the 80 days, which demonstrated that the AnMBR system performed well in the MC and IPA removal...
May 11, 2018: Chemosphere
https://www.readbyqxmd.com/read/29792957/high-activity-production-of-xylanase-by-pichia-stipitis-purification-characterization-kinetic-evaluation-and-xylooligosaccharides-production
#3
Changhe Ding, Mengxing Li, Yuqi Hu
As an industrially important biological macromolecule, xylanase hydrolyzes xylan to produce xylooligosaccarides (XOS). XOS, with a degree of polymerization (DP) 2 to 4, are important prebiotics used as food ingredients. In this study, xylanase (5536 U/g substrate) was produced by Pichia stipitis using corncob and wheat bran mixture under solid state fermentation. Crude xylanase were purified and biochemically characterized. XOS hydrolyzed by crude and purified xylanases were quantified. Molecular weight of the purified enzyme was around 31...
May 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29792498/diagnostic-accuracy-of-a-universal-screening-multiple-gating-procedure-a-replication-study
#4
Stephen P Kilgus, Nathaniel P von der Embse, Crystal N Taylor, Michael P Van Wie, Wesley A Sims
The purpose of this diagnostic accuracy study was to evaluate the sensitivity and specificity (among other indicators) of three universal screening approaches, including the Social, Academic, and Emotional Behavior Risk Screener (SAEBRS), a SAEBRS-based teacher nomination tool, and a multiple gating procedure (MGP). Each screening approach was compared to the BASC-2 Behavioral and Emotional Screening System (BESS), which served as a criterion indicator of student social-emotional and behavioral risk. All data were collected in a concurrent fashion...
May 24, 2018: School Psychology Quarterly
https://www.readbyqxmd.com/read/29792378/location-and-distribution-of-craniomaxillofacial-fractures-in-45-cats-presented-for-the-treatment-of-head-trauma
#5
Ingrid Tundo, Peter Southerden, Andrew Perry, Richard M Haydock
Objectives The aim of this retrospective study was to describe the location and distribution of craniomaxillofacial (CMF) fractures in 45 cats presented to a veterinary referral centre between 2012 and 2017. Methods Cats with a history of head trauma, one or more CMF fractures and a pretreatment CT scan of the CMF region were included in this study. For the purpose of the study, the CMF skeleton was divided into 15 functional anatomical regions and the fracture sites were allocated to one of these functional regions...
May 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29792335/synthesis-of-novel-thymol-derivatives-against-mrsa-and-esbl-producing-pathogenic-bacteria
#6
Shasank S Swain, Sudhir K Paidesetty, Rabindra N Padhy
Twelve substituted aryl-azo-thymol derivatives (4a to 4 l) were synthesized and characterized by several spectral techniques such as, FTIR, UV-vis, proton NMR, Mass spectrometry and elemental analysis. Antimicrobial activities were evaluated by agar-well diffusion method against isolated MRSA, ESBL-producing pathogenic bacteria and antifungal resistant fungi, in vitro. In addition, drug likeness properties of derivatives were assessed through bioinformatic tools such as, PASS prediction, molecular docking and Lipinski rules of five, along with determination of toxic nature and LD50 values...
May 24, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29792296/-it-s-totally-okay-to-be-sad-but-never-lose-hope-content-analysis-of-infertility-related-videos-on-youtube-in-relation-to-viewer-preferences
#7
Margot Kelly-Hedrick, Paul H Grunberg, Felicia Brochu, Phyllis Zelkowitz
BACKGROUND: Infertility patients frequently use the internet to find fertility-related information and support from people in similar circumstances. YouTube is increasingly used as a source of health-related information and may influence health decision making. There have been no studies examining the content of infertility-related videos on YouTube. OBJECTIVE: The purpose of this study was to (1) describe the content of highly viewed videos on YouTube related to infertility and (2) identify video characteristics that relate to viewer preference...
May 23, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29792233/antibiotic-resistance-and-molecular-characterization-of-diarrheagenic-escherichia-coli-and-non-typhoidal-salmonella-strains-isolated-from-infections-in-southwest-china
#8
Shun-Xian Zhang, Yong-Ming Zhou, Li-Guang Tian, Jia-Xu Chen, Rita Tinoco-Torres, Emmanuel Serrano, Shi-Zhu Li, Shao-Hong Chen, Lin Ai, Jun-Hu Chen, Shang Xia, Yan Lu, Shan Lv, Xue-Jiao Teng, Wen Xu, Wen-Peng Gu, Si-Tang Gong, Xiao-Nong Zhou, Lan-Lan Geng, Wei Hu
BACKGROUND: Bacterial diarrhea is one of the most common causes for medical consultations, mortality and morbidity in the world. Diarrheagenic Escherichia coli (DEC) and non-typhoidal Salmonella (NTS) are major intestinal pathogens in developing countries, and the indiscriminate use of antibiotics has greatly contributed to resistant strains. Hence, the aim of the present study is to identify the antimicrobial resistance patterns and the molecular characteristics of DEC and NTS in southwest, China...
May 7, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29792191/cost-of-provision-of-opioid-substitution-therapy-provision-in-tijuana-mexico
#9
Jose Luis Burgos, Javier A Cepeda, James G Kahn, Maria Luisa Mittal, Emilio Meza, Raúl Rafael Palacios Lazos, Psyché Calderón Vargas, Peter Vickerman, Steffanie A Strathdee, Natasha K Martin
BACKGROUND: Mexico recently enacted drug policy reform to decriminalize possession of small amounts of illicit drugs and mandated that police refer identified substance users to drug treatment. However, the economic implications of drug treatment expansion are uncertain. We estimated the costs of opioid substitution therapy (OST) provision in Tijuana, Mexico, where opioid use and HIV are major public health concerns. METHODS: We adopted an economic health care provider perspective and applied an ingredients-based micro-costing approach to quantify the average monthly cost of OST (methadone maintenance) provision at two providers (one private and one public) in Tijuana, Mexico...
May 23, 2018: Harm Reduction Journal
https://www.readbyqxmd.com/read/29792183/estimated-intraoperative-blood-loss-correlates-with-postoperative-cardiopulmonary-complications-and-length-of-stay-in-patients-undergoing-video-assisted-thoracoscopic-lung-cancer-lobectomy-a-retrospective-cohort-study
#10
Shuangjiang Li, Kun Zhou, Yutian Lai, Cheng Shen, Yanming Wu, Guowei Che
BACKGROUND: The purpose of our study was to estimate the influence of estimated intraoperative blood loss (EIBL) on postoperative cardiopulmonary complications (PCCs) in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy for non-small-cell lung cancer (NSCLC). METHODS: We conducted a single-center retrospective analysis on the clinical data of consecutive patients in our institution between April 2015 and February 2016. Demographic differences between PCC group and non-PCC group were initially assessed...
May 23, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29792167/association-between-glaucoma-severity-and-driving-cessation-in-subjects-with-primary-open-angle-glaucoma
#11
Aya Takahashi, Kenya Yuki, Sachiko Awano-Tanabe, Takeshi Ono, Daisuke Shiba, Kazuo Tsubota
BACKGROUND: The aim of this study, which included a baseline cross-sectional study and a 3-year follow-up prospective study, was to investigate the association between glaucomatous visual field damage and driving cessation in subjects with primary open-angle glaucoma (POAG). METHODS: A total of 211 POAG subjects divided into 3 groups according to POAG severity (mild, moderate, or severe) in the better eye were enrolled along with 148 control subjects; subjects were asked about changes in their driving status...
May 23, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29792114/innovating-urinary-catheter-design-an-introduction-to-the-engineering-challenge
#12
Cathy Murphy
Every day, people around the world rely on intermittent and indwelling urinary catheters to manage bladder dysfunction, but the potential or actual harm caused by these devices is well-recognised. Current catheter designs can cause urinary tract infection and septicaemia, bladder and urethral trauma and indwelling devices frequently become blocked. Furthermore, the devices can severely disrupt users' lives, limiting their daily activities and can be costly to manage for healthcare providers. Despite this, little significant design innovation has taken place in the last 80 years...
May 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29792106/psychometric-properties-of-the-photograph-series-of-daily-activities-short-electronic-version-phoda-sev-in-patients-with-chronic-low-back-pain-according-to-cosmin-checklist
#13
Crystian Bitencourt Oliveira, Marcia Rodrigues Franco, Samantha Janaina Demarchi, Rob Johannes E M Smeets, Ivan P J Huijnen, Priscila Kalil Morelhão, Thalysi Mayumi Hisamatsu, Rafael Zambelli Pinto
Study Design A prospective cohort study. Background The Photograph Daily Activities Series - Short Electronic Version (PHODA-SeV) assesses perceived harmfulness of daily activities in patients with low back pain (LBP). Although there is some evidence that the PHODA-SeV is a reliable and valid tool, its psychometric properties have not been fully investigated. Objectives To investigate the test-retest reliability, measurement error, interpretability, construct validity, internal and external responsiveness of the PHODA-SeV in patients with chronic LBP...
May 23, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29792077/symptoms-of-ptsd-in-frontline-journalists-a-retrospective-examination-of-18-years-of-war-and-conflict
#14
Anthony Feinstein, Jonas Osmann, Viral Patel
OBJECTIVE: The objective of the current study was to determine the frequency and severity of symptoms of posttraumatic stress disorder (PTSD) in journalists covering conflict. METHODS: PTSD data (Impact of Event Scale-Revised) collected over an 18-year period from 684 conflict journalists were analyzed retrospectively for frequency and severity of reexperiencing, avoidance, and arousal symptoms. Conflicts covered were civil wars in the Balkans ( n = 140 journalists), 9/11 attack in New York City ( n = 46), Iraq war ( n = 84), Mexico drug wars ( n = 104), civil war in Syria ( n = 59), Kenya election violence/Al-Shabab terror ( n = 57), state-sanctioned media intimidation in Iran ( n = 114), and the current migration crisis in Europe ( n = 80)...
January 1, 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29792061/diet-and-exercise-for-preeclampsia-prevention-in-overweight-and-obese-pregnant-women-systematic-review-and-meta-analysis
#15
Argyro Syngelaki, Miguel Sequeira Campos, Stephanie Roberge, Walkyria Andrade, Kypros H Nicolaides
OBJECTIVE: To investigate the effect of diet and/or exercise in overweight or obese pregnant women on the risk of preeclampsia. METHODS: We performed a systematic review and meta-analysis of randomized controlled trials examining the effect of diet and/or exercise interventions in overweight and obese pregnant women on the risk of preeclampsia (PE) and hypertensive disorders. We completed a literature search through PubMed, Embase, Cinahl, Web of science, Cochrane CENTRAL Library from their earliest entries to November 2017 and from references of other systematic reviews...
May 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29792060/warfarin-monitoring-with-viscoelastic-haemostatic-assays-thrombin-generation-coagulation-factors-and-correlations-to-owren-and-quick-prothrombin-time
#16
Caroline U Nilsson, Karin Strandberg, Peter Reinstrup
The anticoagulant warfarin is commonly monitored with prothrombin time (PT). Viscoelastic haemostatic assays (VHA) are primarily used in situations of acute bleeding to guide haemostatic therapy. Much research has focused on VHA monitoring of new oral anticoagulants. However, many patients are still anticoagulated with warfarin and effect of warfarin anticoagulation on VHA is uncertain. The aim of this study was to assess warfarin anticoagulation on three different VHA and compare these findings with prothrombin time (PT), coagulation factor analyses and a thrombin generation assay (TGA)...
May 23, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29792040/lung-cancer-screening-with-mri-characterization-of-nodules-with-different-non-enhanced-mri-sequences
#17
Michael Meier-Schroers, Rami Homsi, Hans Heinz Schild, Daniel Thomas
Background There is increased interest in pulmonary magnetic resonance imaging (MRI) as a radiation-free alternative to computed tomography (CT) for lung cancer screening. Purpose To analyze MRI characteristics of pulmonary nodules with different non-enhanced sequences. Material and Methods Eighty-two participants of a lung cancer screening were included. MRI datasets of 32 individuals with 46 different nodules ≥ 6 mm were prospectively evaluated together with 50 controls by two readers. Acquired sequences were T2- short tau inversion recovery (STIR), T2, balanced steady-state free precession (bSSFP), 3D-T1, and diffusion-weighted imaging (DWI)...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29792035/3-substituted-1-5-diaryl-1-h-1-2-4-triazoles-as-prospective-pet-radioligands-for-imaging-brain-cox-1-in-monkey-part-2-selection-and-evaluation-of-11c-ps13-for-quantitative-imaging
#18
Stal Shrestha, Prachi Singh, Michelle Y Cortes-Salva, Kimberly J Jenko, Masamichi Ikawa, Min-Jeong Kim, Masato Kobayashi, Cheryl L Morse, Robert L Gladding, Jeih-San Liow, Sami S Zoghbi, Masahiro Fujita, Robert B Innis, Victor W Pike
In our preceding paper (Part 1), we identified three 1,5-bis-diaryl-1,2,4-triazole-based compounds that merited evaluation as potential PET radioligands for selectively imaging COX-1 in monkey and human brain, namely (1,5-bis-(4-methoxyphenyl)-3-(alkoxy)-1 H -1,2,4-triazoles bearing a 3-methoxy (PS1), a 3-(2,2,2-trifluoroethoxy) (PS13), or a 3-fluoromethoxy substituent (PS2). PS1 and PS13 were labeled by O -11C-methylation reactions with [11C]iodomethane, and PS2 by O -18F-fluoroalkylation with [ d 2-18F]fluorobromomethane...
May 23, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29792018/predictive-factors-of-a-poor-outcome-following-revascularization-for-critical-limb-ischemia-implications-for-practice
#19
Mireia Martínez, Claudia Sosa, Alina Velescu, Carme Llort, Roberto Elosua, Albert Clarà
BACKGROUND/OBJECTIVE: Advancements in open and endovascular techniques have brought a widespread indication of revascularization in the majority of patients with critical limb ischemia (CLI). However, some cases still have a dismal short-term outcome. Identifying preoperative variables that characterize these patients could be important to prevent futile decisions. The aim of this study was to define predictive risk factors of mortality and/or major amputation after revascularization for CLI...
May 23, 2018: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29792017/correlations-of-serum-cystatin-c-and-hs-crp-with-vascular-endothelial-cell-injury-in-patients-with-active-systemic-lupus-erythematosus
#20
Dong Gao, Juan Shao, Waishu Jin, Xiujuan Xia, Yan Qu
BACKGROUND: To investigate the correlations of serum cystatin C and high-sensitivity C-reactive protein (hs-CRP) with vascular endothelial cell injury in patients with active systemic lupus erythematosus (SLE). METHODS: A total of 80 patients with SLE treated in our hospital from January 2016 to September 2017 were selected and randomly divided into stable-stage group (n=40) and active-stage group (n=40) using a random number table. The expressions of cystatin C and hs-CRPin stable and active stages were compared, and the inner diameters of brachial artery and levels of vascular endothelial growth factors in stable and active stages were also compared...
May 22, 2018: Panminerva Medica
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