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https://www.readbyqxmd.com/read/27926956/-80-years-the-magic-mountain-by-thomas-mann
#1
C Virchow
No abstract text is available yet for this article.
December 2016: Pneumologie
https://www.readbyqxmd.com/read/27926910/esophageal-endosonography-for-the-diagnosis-of-intrapulmonary-tumors-a-systematic-review-and-meta-analysis
#2
Daniël A Korevaar, Sara Colella, René Spijker, Patrick M Bossuyt, Lars Konge, Paul Frost Clementsen, Jouke T Annema
BACKGROUND: Biopsy-based diagnosis in patients with paraesophageal intrapulmonary tumors suspected of lung cancer is crucial for adequate treatment planning. OBJECTIVE: To evaluate the performance of transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in the diagnosis of intrapulmonary tumors located near or adjacent to the esophagus. METHODS: We performed a systematic review (PROSPERO, CRD42016033737) and searched MEDLINE, Embase, BIOSIS Previews, and Web of Science on September 22, 2016, without date or language restrictions...
December 8, 2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27926847/probing-lipid-bilayers-under-ionic-imbalance
#3
Jiaqi Lin, Alfredo Alexander-Katz
Biological membranes are normally under a resting transmembrane potential (TMP), which originates from the ionic imbalance between extracellular fluids and cytosols, and serves as electric power storage for cells. In cell electroporation, the ionic imbalance builds up a high TMP, resulting in the poration of cell membranes. However, the relationship between ionic imbalance and TMP is not clearly understood, and little is known about the effect of ionic imbalance on the structure and dynamics of biological membranes...
December 6, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27926759/mortality-and-prehospital-blood-pressure-in-patients-with-major-traumatic-brain-injury-implications-for-the-hypotension-threshold
#4
Daniel W Spaite, Chengcheng Hu, Bentley J Bobrow, Vatsal Chikani, Duane Sherrill, Bruce Barnhart, Joshua B Gaither, Kurt R Denninghoff, Chad Viscusi, Terry Mullins, P David Adelson
Importance: Current prehospital traumatic brain injury guidelines use a systolic blood pressure threshold of less than 90 mm Hg for treating hypotension for individuals 10 years and older based on studies showing higher mortality when blood pressure drops below this level. However, the guidelines also acknowledge the weakness of the supporting evidence. Objective: To evaluate whether any statistically supportable threshold between systolic pressure and mortality emerges from the data a priori, without assuming that a cut point exists...
December 7, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27926667/sexual-behaviors-and-hiv-status-a-population-based-study-among-older-adults-in-rural-south-africa
#5
Molly S Rosenberg, Francesc X Gómez-Olivé, Julia K Rohr, Brian C Houle, Chodziwadziwa W Kabudula, Ryan G Wagner, Joshua A Salomon, Kathleen Kahn, Lisa F Berkman, Stephen M Tollman, Till Bärnighausen
OBJECTIVE: To identify the unmet needs for HIV prevention among older adults in rural South Africa. METHODS: We analyzed data from a population-based sample of 5059 men and women aged 40 years and older from the study Health and Aging in Africa: Longitudinal Studies of INDEPTH Communities (HAALSI), which was carried out in the Agincourt health and sociodemographic surveillance system in the Mpumalanga province of South Africa. We estimated the prevalence of HIV (laboratory-confirmed and self-reported) and key sexual behaviors by age and sex...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27926555/avoiding-radical-surgery-in-elderly-patients-with-rectal-cancer-is-cost-effective
#6
Christopher Rao, Arthur Sun Myint, Thanos Athanasiou, Omar Faiz, Antony Paul Martin, Brendan Collins, Fraser McLean Smith
BACKGROUND: Radical surgery is associated with significant perioperative mortality in elderly and comorbid populations. Emerging data suggest for patients with a clinical complete response after neoadjuvant chemoradiotherapy that a watch-and-wait approach may provide equivalent survival and oncological outcomes. OBJECTIVE: The purpose of this study was to compare the cost-effectiveness of watch and wait and radical surgery for patients with rectal cancer after a clinical complete response following chemoradiotherapy...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27926481/metformin-therapy-and-risk-of-colorectal-adenomas-and-colorectal-cancer-in-type-2-diabetes-mellitus-patients-a-systematic-review-and-meta-analysis
#7
REVIEW
Feifei Liu, Lijing Yan, Zhan Wang, Yuanan Lu, Yuanyuan Chu, Xiangyu Li, Yisi Liu, Dongsheng Rui, Shaofa Nie, Hao Xiang
Recent evidence indicates that metformin therapy may be associated with a decreased colorectal adenoma/colorectal cancer risk in type 2 diabetes patients. However, results are not consistent. We therefore performed a systematic review and meta-analysis to assess the association between metformin therapy and risk of colorectal adenomas/colorectal cancer in type 2 diabetes mellitus patients. We searched the literature published before Aug 31, 2016 in four databases: PubMed, Embase database, CNKI and VIP Library of Chinese Journal...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27925855/costs-associated-with-influenza-related-hospitalization-in-the-elderly
#8
Núria Torner, Encarna Navas, Núria Soldevila, Diana Toledo, Gemma Navarro, Aurea Morillo, Maria José Pérez, Angela Domínguez
Seasonal influenza epidemics remain a considerable burden in adults, especially in those at higher risk of complications. The aim of this study was to determine the costs associated with influenza-related hospitalization in patients aged ≥65 years admitted to 20 hospitals from seven Spanish regions during the 2013-14 and 2014-15 influenza seasons. Bivariate analysis was used to compare costs in vaccinated and unvaccinated cases. Costs were calculated according to the Spanish National Health System diagnosis-related group tables for influenza and other respiratory system conditions (GRD 89 and GRD 101)...
December 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27925837/a-comprehensive-multimorbidity-index-for-predicting-mortality-in-intensive-care-unit-patients
#9
Hua Min, Sanja Avramovic, Janusz Wojtusiak, Rahul Khosla, Ross D Fletcher, Farrokh Alemi, Raya Elfadel Kheirbek
BACKGROUND: Accurate prediction of mortality for patients admitted to the intensive care units (ICUs) is an important component of medical care. However, little is known about the role of multimorbidity in predicting end of life for high-risk and vulnerable patients. OBJECTIVE: The aim of the study was to derive and validate a multimorbidity risk model in an attempt to predict all-cause mortality at 6 and 12 months posthospital discharge. METHODS: This is a retrospective, observational, clinical cohort study...
December 7, 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27925723/first-constraints-on-the-complete-neutrino-mixing-matrix-with-a-sterile-neutrino
#10
G H Collin, C A Argüelles, J M Conrad, M H Shaevitz
Neutrino oscillation models involving one extra mass eigenstate beyond the standard three (3+1) are fit to global short baseline experimental data and the recent IceCube ν_{μ}+ν[over ¯]_{μ} disappearance search result. We find a best fit of Δm_{41}^{2}=1.75  eV^{2} with Δχ_{null-min}^{2}/d.o.f. of 50.61/4. We find that the combined IceCube and short baseline data constrain θ_{34} to <80°(<6°) at 90% C.L. for Δm_{41}^{2}≈2(6)  eV^{2}, which is improved over present limits. Incorporating the IceCube information provides the first constraints on all entries of the 3+1 mixing matrix...
November 25, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27925706/influence-of-temperature-and-brewing-time-of-nettle-urtica-dioica-l-infusions-on-vitamin-c-content
#11
Jolanta Wolska, Michał Czop, Karolina Jakubczyk, Katarzyna Janda
Background: Stinging nettle (Urtica dioica L.) can be found in temperate climate zones of Europe, Africa and America Nettle may be a source of nutritional ingredients, mineral salts, vitamins and antioxidants. Objective: The aim of the study was to determine the effect of temperature and brewing time Urtica dioica L. infusions from different parts of this plant on vitamin C (ascorbic acid) content. Material and methods: Infusions of nettle leaf, stem and root were prepared at room temperature, 50°C, 60°C, 70°C and 80°C for 10 minutes...
2016: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/27925679/value-of-shear-wave-elastography-versus-contrast-enhanced-sonography-for-differentiating-benign-and-malignant-superficial-lymphadenopathy-unexplained-by-conventional-sonography
#12
Shi Tan, Li-Ying Miao, Li-Gang Cui, Peng-Fei Sun, Lin-Xue Qian
OBJECTIVES: This study aimed to compare the efficacy of shear wave elastography (SWE) and contrast-enhanced sonography in the differential diagnosis of superficial lymphadenopathy with abnormal imaging findings, which could not be otherwise confirmed by conventional sonography. METHODS: Forty-two enlarged superficial lymph nodes in 42 patients who met the screening criteria for this study were evaluated by both contrast-enhanced sonography and SWE. All lymph nodes underwent both methods using biopsy pathologic findings as a reference standard...
November 30, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27925657/population-pharmacokinetics-of-cefazolin-in-serum-and-adipose-tissue-from-overweight-and-obese-women-undergoing-cesarean-delivery
#13
Mordechai Grupper, Joseph L Kuti, Morgan L Swank, Lindsay Maggio, Brenna L Hughes, David P Nicolau
The optimal antibiotic prophylaxis dosing regimen of cefazolin for cesarean delivery (CD) in overweight and obese women is unknown. This study was done to compare the duration that cefazolin concentrations remain above the minimum inhibitory concentration (MIC) in adipose tissue (AT). Serum and AT concentrations from 3 previous studies in CD patients were comodeled using the nonparametric adaptive grid algorithm in Pmetrics. AT concentrations for 5000 overweight and obese patients receiving 1-, 2-, and 3-g cefazolin regimens were simulated to calculate the probability that free drug concentrations remained above an MIC of 2 μg/mL at 1, 1...
December 7, 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27925656/mold-and-dampness-exposure-and-allergic-outcomes-from-birth-to-adolescence-data-from-the-bamse-cohort
#14
Jesse D Thacher, Olena Gruzieva, Göran Pershagen, Erik Melén, Johnny C Lorentzen, Inger Kull, Anna Bergström
BACKGROUND: Exposure to moldy or damp indoor environments is associated with allergic disease in young children, but it is unclear if the effects persist to adolescence. Our objective was to assess if exposure to mold or dampness during infancy increases the risk of asthma, rhinitis, or IgE sensitization in children followed from birth to 16 years of age. METHODS: We collected questionnaire derived reports of mold or dampness indicators and allergic outcomes from 3798 children in a Swedish birth cohort (BAMSE)...
December 7, 2016: Allergy
https://www.readbyqxmd.com/read/27925508/%C3%AE-cyclodextrin-carbon-nanotube-enhanced-sensor-for-ciprofloxacin-detection
#15
Jorge M P J Garrido, Manuel Melle-Franco, Karol Strutyński, Fernanda Borges, Christopher M A Brett, E Manuela P J Garrido
A simple and expedite electrochemical methodology was developed for the determination of ciprofloxacin, based on a glassy carbon (GC) electrode modified by a combination of multi-walled carbon nanotubes (MWCNT) with β-cyclodextrin (β-CD) incorporated in a polyaniline film. The combined use of β-CD and MWCNT in the electrochemical sensor leads to a significant signal improvement. The β-CD/MWCNT modified GC electrode exhibited efficient electrocatalytic behavior in the oxidation of ciprofloxacin with relatively high sensitivity, stability and lifetime...
December 7, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27925493/the-effect-of-freeze-drying-on-the-nutrient-polyphenol-and-oxidant-levels-of-breast-milk
#16
Mariela Valentina Cortez, Elio Andrés Soria
OBJECTIVES: Human milk banks need to extend the suitability of milk for breastfeeding, and for this technological advances are required. Our aim was to establish the capacity of freeze-drying to conserve milk properties without further oxidative deterioration. METHODS: One hundred sixteen healthy women participated from the city of Cordoba (Argentina). Proteins, glucose, triglycerides, polyphenols, and markers (nitrites, superoxide anion, hydroperoxides, lipoperoxides, and γ-glutamyl transpeptidase) were measured in their fresh milk...
December 2016: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/27925304/dura-mater-graft-associated-creutzfeldt-jakob-disease-with-30-year-incubation-period
#17
Masahiro Shijo, Hiroyuki Honda, Sachiko Koyama, Koji Ishitsuka, Koichiro Maeda, Junya Kuroda, Mitsugu Tanii, Takanari Kitazono, Toru Iwaki
Over 60% of all patients with dura mater graft-associated Creutzfeldt-Jakob disease (dCJD) have been diagnosed in Japan. The incubation period has ranged from 1 to 30 years and the age at onset from 15 to 80 years. Here, we report a 77-year-old male Japanese autopsied dCJD case with the longest incubation period so far in Japan. He received a cadaveric dural graft at the right cranial convexity following a craniotomy for meningioma at the age of 46. At 30 years post-dural graft placement, disorientation was observed as an initial symptom of dCJD...
December 7, 2016: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/27925162/facial-dysmorphism-is-influenced-by-ethnic-background-of-the-patient-and-of-the-evaluator
#18
Aimé Lumaka, Nele Cosemans, Aimée Lulebo Mampasi, Gerrye Mubungu, Nono Mvuama, Toni Lubala, Sebastien Mbuyi-Musanzayi, Jeroen Breckpot, Maureen Holvoet, Thomy De Ravel, Griet Van Buggenhout, Hilde Peeters, Dian Donnai, Leon Mutesa, Alain Verloes, Prosper Lukusa Tshilobo, Koenraad Devriendt
The evaluation of facial dysmorphism is a critical step toward reaching a diagnostic. The aim of the present study was to evaluate the ability to interpret facial morphology in African children with intellectual disability (ID). First, 10 experienced clinicians (5 from Africa and 5 from Europe) rated gestalt in 127 African non-Down Syndrome (non-DS) patients using either the score 2 for "clearly dysmorphic", 0 for "clearly non dysmorphic" or 1 for "uncertain". The inter-rater agreement was determined using kappa coefficient...
December 7, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27925094/technology-for-self-care-for-ostomized-women-s-sexual-and-reproductive-health
#19
Andressa Ferreira Leite Ladislau Albuquerque, Ana Karina Bezerra Pinheiro, Francisca Márcia Pereira Linhares, Tatiane Gomes Guedes
Objective: to validate the technology of printed booklets on self-care for ostomized women's sexual and reproductive health. Method: a methodological study was performed with a focus on the construction and validity of a printed booklet. The content of this booklet was validated by 11 specialist judges/nurses, according to a Content Validity Index (CVI) equal to or higher than 0.80. Appearance was validated by nine ostomized women, according to an assessment of the difficulty and convenience of the educational material...
November 2016: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/27925041/wake-up-stroke-clinical-characteristics-sedentary-lifestyle-and-daytime-sleepiness
#20
Deborath Lucia de Oliveira Diniz, Pedro Rodrigues Barreto, Pedro Felipe Carvalhedo de Bruin, Veralice Meireles Sales de Bruin
Objective: Wake-up stroke (WUS) is defined when the exact time of the beginning of the symptoms cannot be determined, for the deficits are perceived upon awakening. Sleep alterations are important risk factors for stroke and cardiovascular diseases. This study evaluates the characteristics of patients with and without WUS, the presence of daytime sleepiness, and associated risk factors. Method: Patients with ischemic stroke were investigated about the presence of WUS...
October 2016: Revista da Associação Médica Brasileira
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