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https://www.readbyqxmd.com/read/28103625/phase-ii-study-of-imatinib-based-chemotherapy-for-newly-diagnosed-bcr-abl-positive-acute-lymphoblastic-leukemia
#1
Shin Fujisawa, Shuichi Mizuta, Hideki Akiyama, Yasunori Ueda, Yasutaka Aoyama, Yoshihiro Hatta, Kazuhiko Kakihana, Nobuaki Dobashi, Isamu Sugiura, Yasushi Onishi, Tomoya Maeda, Kiyotoshi Imai, Shigeki Ohtake, Yasushi Miyazaki, Kazunori Ohnishi, Keitaro Matsuo, Tomoki Naoe
This study investigated the efficacy of imatinib based therapy with intensified consolidation therapy in patients with Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL) to prevent early relapse. We conducted a phase II trial of imatinib-combined chemotherapy for newly diagnosed BCR-ABL-positive ALL in adults. Sixty-eight patients were included in the trial between October 2008 and December 2010. The median age was 49 years, with 28 patients >55 years of age. Sixty-five patients achieved CR (95...
January 19, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28103600/indicators-of-adiposity-predictors-of-metabolic-syndrome-in-the-elderly
#2
Carolina Cunha de Oliveira, Anna Karla C Roriz, Lilian B Ramos, Mansueto Gomes Neto
BACKGROUND: Adiposity indicators can be used as predictors of cardiovascular risk in the elderly. However, there are only a very few studies that deal with the accuracy of adiposity indicators as predictors of metabolic syndrome (MS) in the elderly. We evaluated the performance of adiposity indicators of MS prediction in the elderly. METHODS: A cross-sectional study with 203 elderly people of both genders. VARIABLES: MS defined by harmonized criteria, waist circumference (WC), waist-to-height ratio (WHtR), conicity index (CI), lipid accumulation product (LAP), and visceral adiposity index (VAI)...
January 20, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28103578/prognostic-and-predictive-value-of-vhl-gene-alteration-in-renal-cell-carcinoma-a-meta-analysis-and-review
#3
Bum Jun Kim, Jung Han Kim, Hyeong Su Kim, Dae Young Zang
The von Hippel-Lindau (VHL) gene is often inactivated in sporadic renal cell carcinoma (RCC) by mutation or promoter hypermethylation. The prognostic or predictive value of VHL gene alteration is not well established. We conducted this meta-analysis to evaluate the association between the VHL alteration and clinical outcomes in patients with RCC. We searched PUBMED, MEDLINE and EMBASE for articles including following terms in their titles, abstracts, or keywords: 'kidney or renal', 'carcinoma or cancer or neoplasm or malignancy', 'von Hippel-Lindau or VHL', 'alteration or mutation or methylation', and 'prognostic or predictive'...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28103515/strong-synergistic-effects-in-pla-pcl-blends-impact-of-pla-matrix-viscosity
#4
Aleksandra Ostafinska, Ivan Fortelný, Jiří Hodan, Sabina Krejčíková, Martina Nevoralová, Jana Kredatusová, Zdeněk Kruliš, Jiří Kotek, Miroslav Šlouf
Blends of two biodegradable polymers, poly(lactic acid) (PLA) and poly(ϵ-caprolactone) (PCL), with strong synergistic improvement in mechanical performance were prepared by melt-mixing using the optimized composition (80/20) and the optimized preparation procedure (a melt-mixing followed by a compression molding) according to our previous study. Three different PLA polymers were employed, whose viscosity decreased in the following order: PLC ≈ PLA1 > PLA2 > PLA3. The blends with the highest viscosity matrix (PLA1/PCL) exhibited the smallest PCL particles (d∼0...
January 10, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28103455/-epidemiological-and-demographic-characteristics-of-patients-with-head-and-neck-tumours-in-the-northern-portugal-impact-on-survival
#5
Roberto Estêvão, Tiago Santos, Ana Ferreira, Anabela Machado, João Fernandes, Eurico Monteiro
INTRODUCTION: In Portugal there are still no epidemiological and demographic studies conducted in patients with of the head and neck tumors. The objectives of this analysis are to describe the epidemiological and demographics of patients with malignant tumors of the head and neck referred to an Ear, Nose and Throat department of an oncology center in the North of Portugal and also assess the impact of these characteristics on survival. MATERIAL AND METHODS: Retrospective study of patients referred between January 2011 and December 2013 to the Ear, Nose and Throat Department of an oncology center (Instituto Português de Oncologia do Porto),...
October 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28103433/baseline-extent-of-damage-predicts-spinal-radiographic-progression-in-korean-patients-with-ankylosing-spondylitis-treated-with-golimumab
#6
Jeong Seok Lee, Yeong Wook Song, Tae Hwan Kim, Won Tae Jung, Seung Geun Lee, Sung Hwan Park, Gwan Gyu Song, Dae Young Yu, Stephen Xu, Eun Young Lee
Background/Aims: For patients with ankylosing spondylitis (AS), golimumab has consistent efficacy in controlling disease activity over 5 years but its benefit in preventing radiographic progression was less clear at 4 years. To predict radiographic progression, we analyzed the baseline characteristics of AS patients in a Korean population. Methods: Sixty-eight Korean patients with AS participated in the phase 3, multicenter, randomized, placebo-controlled, double-blind trial (GO-RAISE) which has previously been described...
January 20, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28103273/association-between-genetic-polymorphisms-in-interleukin-genes-and-recurrent-pregnancy-loss-a-systematic-review-and-meta-analysis
#7
Meixiang Zhang, Jiawei Xu, Xiao Bao, Wenbin Niu, Linlin Wang, Linqing Du, Nan Zhang, Yingpu Sun
Interleukins are a group of immunomodulatory proteins that mediate a variety of immune reactions in the human body. To investigate the association between interleukin gene polymorphisms and recurrent pregnancy loss (RPL), we reviewed 21 studies from MEDLINE, EMBASE, OVID SP and PubMed to evaluate RPL-related interleukin gene polymorphisms. Meta-analysis was performed on 12 of the polymorphisms, and a review included the others. Our integrated results indicated that IL-1β (-511C/T) (P = 0.02, 95% CI 0.77[0...
2017: PloS One
https://www.readbyqxmd.com/read/28102942/a-platform-independent-method-to-reduce-ct-truncation-artifacts-using-discriminative-dictionary-representations
#8
Yang Chen, Adam Budde, Ke Li, Yinsheng Li, Jiang Hsieh, Guang-Hong Chen
PURPOSE: When the scan field of view (SFOV) of a CT system is not large enough to enclose the entire cross-section of the patient, or the patient needs to be positioned partially outside the SFOV for certain clinical applications, truncation artifacts often appear in the reconstructed CT images. Many truncation artifact correction methods perform extrapolations of the truncated projection data based on certain a priori assumptions. The purpose of this work was to develop a novel CT truncation artifact reduction method that directly operates on DICOM images...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102899/b-type-natriuretic-peptide-guided-treatment-for-heart-failure
#9
REVIEW
Julie McLellan, Carl J Heneghan, Rafael Perera, Alison M Clements, Paul P Glasziou, Karen E Kearley, Nicola Pidduck, Nia W Roberts, Sally Tyndel, F Lucy Wright, Clare Bankhead
BACKGROUND: Heart failure is a condition in which the heart does not pump enough blood to meet all the needs of the body. Symptoms of heart failure include breathlessness, fatigue and fluid retention. Outcomes for patients with heart failure are highly variable; however on average, these patients have a poor prognosis. Prognosis can be improved with early diagnosis and appropriate use of medical treatment, use of devices and transplantation. Patients with heart failure are high users of healthcare resources, not only due to drug and device treatments, but due to high costs of hospitalisation care...
December 22, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28102898/a-composite-autonomic-index-as-unitary-metric-for-heart-rate-variability-a-proof-of-concept
#10
Roberto Sala, Mara Malacarne, Nadia Solaro, Massimo Pagani, Daniela Lucini
BACKGROUND: This study addresses whether a unitary cardiac autonomic nervous system index (ANSI), obtained combining multiple metrics from Heart Rate Variability (HRV) into a radar plot could provide an easy appreciation of autonomic performance in a clinical setting. MATERIALS AND METHODS: Data are standardized using percentile ranking of autonomic proxies from a relatively large reference population (n= 1593, age 39±13 years). Autonomic indices are obtained from autoregressive spectral analysis of (ECG derived) HRV at rest and during standing up...
January 19, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28102653/the-effect-of-prenatal-and-postnatal-education-on-exclusive-breastfeeding-rates
#11
Fisun Vural, Birol Vural
BACKGROUND: Despite the benefits of breastfeeding, exclusive breastfeeding (EBF) rates remain low globally. Breastfeeding support has increased the initiation and duration of breastfeeding, but the optimal timing, support, and roles of antenatal and postnatal interventions are unclear. This prospective study aimed to investigate whether the addition of individual postnatal support to antenatal group counseling improved the rates of EBF until six months postpartum. METHODS: A total of 240 women who attended antenatal breastfeeding education sessions offered for postnatal support in the second and sixth weeks after delivery...
February 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28102615/comparative-effectiveness-of-venous-thromboembolism-prophylaxis-options-for-the-patient-undergoing-total-hip-and-knee-replacement-a-network-meta-analysis
#12
A Kapoor, A Ellis, N Shaffer, J Gurwitz, A Chandramohan, J Saulino, A Ishak, T Okubanjo, F Michota, E Hylek, T A Trikalinos
: Essentials Despite trial data, guidelines have not endorsed direct oral Xa inhibitors above other options. We provide profiles of venous thromboembolism and hemorrhage risk for 12 options. Direct oral Xa inhibitors had a favorable profile compared with low-molecular-weight heparin. Other options did not have favorable profiles compared with low-molecular-weight heparin. SUMMARY: Background There are numerous trials and several meta-analyses comparing venous thromboembolism (VTE) prophylaxis options after total hip and knee replacement (THR and TKR)...
November 7, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28102497/regulated-partitioning-of-fixed-carbon-14-c-sodium-na-potassium-k-and-glycine-betaine-determined-salinity-stress-tolerance-of-gamma-irradiated-pigeonpea-cajanus-cajan-l-millsp
#13
Pankaj Kumar, Vasundhara Sharma, Chobhe Kapil Atmaram, Bhupinder Singh
Soil salinity is a major constraint that limits legume productivity. Pigeonpea is a salt sensitive crop. Seed gamma irradiation at a very low dose (2.5 Gy) is known to enhance seedling establishment, plant growth and yield of cereals and other crops. The present study conducted using two genetically diverse varieties of pigeonpea viz., Pusa-991 and Pusa-992 aimed at establishing the role of pre-sowing seed gamma irradiation at 0, 0.0025, 0.005, 0.01, 0.02, 0.05 and 0.1 kGy on plant growth, seed yield and seed quality under salt stress at 0, 80 and 100 mM NaCl (soil solution EC equivalent 1...
January 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28102295/bioactive-compounds-and-antioxidant-activity-of-wolfberry-infusion
#14
Yujing Sun, Japaer Rukeya, Wenyang Tao, Peilong Sun, Xingqian Ye
An infusion of the wolfberry (Lycium barbarum L.) is a traditional Asian herbal tea. This is the most commonly consumed form of dried wolfberry worldwide, yet little scientific information on wolfberry infusions is available. We investigated the effects of making infusions with hot water on the color, the content of bioactive compounds (polysaccharides, polyphenols, flavonoids and carotenoids) and the antioxidant ability of wolfberry infusions. The contents of bioactive compounds and the antioxidant activity of a wolfberry infusion increased with increased infusion temperature and time...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102167/assessment-and-comparison-of-the-efficacy-of-rehabilitation-conducted-at-a-sanatorium-and-in-an-outpatient-facility-in-patients-with-low-back-pain-pilot-study
#15
Jakub Szewczyk
BACKGROUND: Low back pain is nowadays believed to be one of the most serious and common health problems and is even often classified as a disease of civilisation. Prevention and treatment of such conditions is very important, particularly taking into consideration the fact that they are increasingly common in young people. Low back pain is effectively prevented and treated with rehabilitation. The aim of this paper was to assess and compare rehabilitation procedures performed in patients with low back pain in the sanatorium setting and on an outpatient basis...
August 30, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28102107/occupational-dietary-and-other-risk-factors-for-myelodysplastic-syndromes-in-western-greece
#16
Christina Avgerinou, Ioanna Giannezi, Stela Theodoropoulou, Vasileios Lazaris, Georgia Kolliopoulou, Panagiotis Zikos, Yannis Alamanos, Michalis Leotsinidis, Argiris Symeonidis
PURPOSE: We have observed an increasing incidence of myelodysplastic syndromes (MDS) in the geographic area of Western Greece during the past two decades. The objective of this study was to investigate potential risk factors for the manifestation of MDS in this area of Greece. METHODS: A hospital-based case-control study was conducted in the public hospitals of the region. Participants were interviewed based on a questionnaire regarding demographics, occupational exposures, smoking, alcohol consumption, dietary, and domestic factors...
January 19, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28102027/patient-engagement-in-hiv-care-and-treatment-in-zambia-2004-2014
#17
Neo Christopher Chung, Carolyn Bolton-Moore, Roma Chilengi, Margaret P Kasaro, Jeffrey S A Stringer, Benjamin H Chi
OBJECTIVE: To describe engagement along the HIV continuum of care using a large network of clinics in Zambia. METHODS: We employed a practical framework to describe retention along the HIV treatment cascade, using routinely collected clinical data available in resource-constrained settings. We included health facilities in four Zambian provinces with more than 300 enrolled patients over the age of 5 years. We described attrition at each step, from HIV enrolment to 720 days after ART initiation...
January 19, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28102012/visual-perception-of-faces-with-unilateral-and-bilateral-cleft-lip-and-palate-an-eye-tracking-study
#18
Furkan Dindaroğlu, Servet Doğan, Sonia Amado, Ege Doğan
OBJECTIVES: To test the hypotheses that there are differences between orthodontists, individuals with cleft lip and palate (CLP) and laypersons in the visual perception of faces with unilateral (UCLP) and bilateral cleft lip and palate (BCLP), the faces with UCLP and BCLP are visually perceived differently and the hierarchy of visual attention changes when viewing individuals with CLP. SETTING AND SAMPLE POPULATION: Department of Orthodontics and Experimental Psychology at Ege University, İzmir...
February 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28102004/prevalence-and-causes-of-hearing-impairment-in-fundong-health-district-north-west-cameroon
#19
Silvia Ferrite, Islay Mactaggart, Hannah Kuper, Joseph Oye, Sarah Polack
OBJECTIVE: To estimate the prevalence and causes of hearing impairment in Fundong Health District, North West Cameroon. METHODS: We selected 51 clusters of 80 people through probability proportionate to size sampling. Initial hearing screening was undertaken through an otoacoustic emission (OAE) test. Participants aged 4+ years who failed this test in both ears or for whom an OAE reading could not be taken underwent a manual pure-tone audiometry (PTA) screening...
January 18, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28101886/incident-alopecia-areata-and-vitiligo-in-adult-women-with-atopic-dermatitis-nurses-health-study-2
#20
Aaron M Drucker, Jordan M Thompson, Wen-Qing Li, Eunyoung Cho, Tricia Li, Emma Guttman-Yassky, Abrar A Qureshi
We aimed to determine the risk of AA and vitiligo associated with AD in a large cohort of US women, the Nurses' Health Study 2. We used logistic regression to calculate age- and multivariate-adjusted odds ratios to determine the risk of incident AA and vitiligo associated with AD diagnosed in or before 2009. A total of 87,406 and 87,447 participants were included in the AA and vitiligo analyses, respectively. A history of AD in 2009 was reported in 11% of participants. There were 147 incident cases of AA and 98 incident cases of vitiligo over 2 years of follow-up...
January 19, 2017: Allergy
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