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Rintaro Iwata Hara, Aya Yaoita, Katsuya Takeda, Hiroaki Ueki, Ayumu Ishii, Hideyuki Imoto, Satoshi Kobayashi, Michi Sano, Mihoko Noro, Kazuki Sato, Takeshi Wada
Bacterial and protozoan sugar chains contain glycosyl 1-phosphate repeating structures; these repeating structures have been studied for vaccine development. The fluorinated analogues of [β-Gal-(1→4)-α-Man-(1→6)-P-] n , which are glycosyl 1-phosphate repeating structures found in Leishmania , were synthesised using the solid-phase phosphoramidite method. This method has been less extensively studied for the synthesis of glycosyl 1-phosphate units than H -phosphonate chemistry. A stepwise synthesis of a compound containing five such repeating units has been conducted using the phosphoramidite method herein, which is the longest glycosyl 1-phosphate structures to be chemically constructed in a stepwise manner...
June 2018: ChemistryOpen
Masaru Kawanishi, Takeshi Fukuda, Masahiro Shimomura, Yuta Inoue, Takuma Wada, Reiko Tasaka, Tomoyo Yasui, Toshiyuki Sumi
The standard treatment for ovarian serous carcinoma is maximum debulking surgery and platinum-based chemotherapy. Despite the high response rate for chemotherapy, the majority of patients will be resistant to first-line agents and the prognosis for these patients is particularly poor. Currently there are no reliable methods to determine or predict platinum resistance. Uncoupling protein 2 (UCP2) is widely expressed in cancer cells and regulates the production of mitochondrial reactive oxygen species (ROS). A reduction in ROS is associated with carcinogenesis and chemoresistance...
June 2018: Oncology Letters
Yuki Kakio, Haruhito Adam Uchida, Masashi Kitagawa, Yuka Arata, Ayako Kato, Akiko Inoue-Torii, Norikazu Hinamoto, Ayu Ogawa-Akiyama, Hitoshi Sugiyama, Jun Wada
Renal involvement is occasionally observed in Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT). It has been reported that galactose-deficient IgA is a closely linked to IgA nephropathy (IgAN), suggesting that patients with XLT/WAS associated with reduced galactosylation on serum IgA are susceptible to IgAN. It is necessary to pay more attention to patients with IgAN due to the potential complication with XLT/WAS. We here present a patient of XLT complicated with mild IgAN who underwent tonsillectomy combined with steroid pulse therapy to achieve complete clinical remission...
June 2018: Acta Medica Okayama
Takahiro Tsuboyama, Oki Takei, Atsuhiko Okada, Keiko Wada, Keiko Kuriyama
No abstract text is available yet for this article.
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
Yuriko Harada, Kenji Takeuchi, Michiko Furuta, Akihiko Tanaka, Shunichi Tanaka, Naohisa Wada, Yoshihisa Yamashita
This study aim was to examine whether the presence of untreated caries is different across occupational status among Japanese adults. This was a cross-sectional survey of 1,342 individuals (990 males and 352 females) aged 40-64 years who underwent medical and dental checkups at a healthcare center in 2011. Oral examination was performed by a dentist and the presence of untreated caries was defined as having at least one untreated decayed tooth. Data regarding current occupational status were obtained using a self-administered questionnaire; the participants were classified into five groups: professionals and managers, clerical and related workers, service and salespersons, agricultural, forestry, and fishery workers, and homemakers and unemployed...
June 21, 2018: Industrial Health
Surein Arulananda, James Lynam, Mun Sem Liew, Morikatsu Wada, Lawrence Cher, Hui K Gan
INTRODUCTION: This study was done retrospectively to evaluate rates of thrombocytopenia and their clinical impact during chemo-radiotherapy for glioblastomas and to elucidate associated clinical factors. METHODS: Sixty-four patients who received temozolomide chemotherapy at our institution were included. Thirty-five patients received full dose chemo-radiotherapy as per the STUPP protocol (Group A) and nine patients received abbreviated radiotherapy with concurrent chemotherapy (Group B)...
June 19, 2018: Internal Medicine Journal
Taizo Wada
CD5 is a cell surface molecule that is expressed on most circulating T cells and a small population of B cells and is involved in modulation of antigen-specific receptor-mediated activation. Down-regulation of CD5 on CD8+ T cells is a poorly understood but increasingly recognized phenomenon that may be associated with dysregulated T-cell activation. An increased subpopulation of activated CD8+ T cells with down-regulation of CD5 has recently been described in patients with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (HLH) and familial HLH caused by perforin deficiency and Munc 13-4 deficiency...
June 19, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
Go Shinke, Daisaku Yamada, Hidetoshi Eguchi, Yoshifumi Iwagami, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Koichi Kawamoto, Kunihito Gotoh, Shogo Kobayashi, Yutaka Takeda, Masahiro Tanemura, Masaki Mori, Yuichiro Doki
Current therapies for pancreatic ductal cancer (PDAC) do not sufficiently control distant metastasis. Thus, new therapeutic targets are urgently needed. Numerous studies have suggested that the epithelial-mesenchymal transition (EMT) is pivotal for metastasis of carcinomas. The fact that the EMT is reversible suggests the possibility that it is induced by an epigenetic mechanism. In this study, we aimed to investigate the role of histone deacetylase 1 (HDAC1), which is an epigenetic mechanism on distant metastasis of PDAC...
June 19, 2018: Cancer Science
Eiji Kutoh, Asuka Wada, Teruma Murayama, Jyunka Hayashi
Objectives: The aim of this project is to compare the effect of canagliflozin monotherapy on metabolic parameters between responders and nonresponders with this drug. This study is a prospective, unblinded, observational study. Subjects and Methods: Drug-naïve patients with type 2 diabetes mellitus received only 50-100 mg/day canagliflozin for 3 months ( n = 39). They were divided into two groups according to the novel "A1c index" to assess glycemic efficacies; responders ( n = 24) and nonresponders ( n = 15)...
March 2018: Indian Journal of Endocrinology and Metabolism
Cristina Gardelli, Hiroki Wada, Asim Ray, Moya Caffrey, Antonio Llinas, Igor Shamovsky, Joakim Tholander, Joakim Larsson, Ulf Sivars, Leif Hultin, Ulf Andersson, Hitesh J Sanganee, Kristina Stenvall, Brith Leidvik, Karin Gedda, Lisa Jinton, Marie Ryden Landergren, Kostas Karabelas
Cachexia and muscle wasting are very common among patients suffering from cancer, chronic obstructive pulmonary disease and other chronic diseases. Ghrelin stimulates growth hormone secretion via the ghrelin receptor, which subsequently leads to increase of IGF-1 plasma levels. The activation of the GH/IGF-1 axis leads to an increase of muscle mass and functional capacity. Ghrelin further acts on inflammation, appetite and adipogenesis, and for this reason was considered an important target to address catabolic conditions...
June 17, 2018: Journal of Medicinal Chemistry
Chika Ikenoya, Shota Takemi, Arisa Kaminoda, Sayaka Aizawa, Shiomi Ojima, Zhi Gong, Rakhi Chacrabati, Daisuke Kondo, Reiko Wada, Toru Tanaka, Sachiko Tsuda, Takafumi Sakai, Ichiro Sakata
Ghrelin is a unique fatty acid-modified peptide hormone produced in the stomach and has important roles in energy homeostasis and gastrointestinal motility. However, the medium-chain fatty acid source for ghrelin acyl-modification is not known. We found that a fat-free diet and the removal of intestinal microbiota did not decrease acyl-ghrelin production in the stomach or plasma acyl-ghrelin levels in mice. RT-PCR analysis showed that genes involving fatty acid synthesis, metabolism, and transport were expressed in pancreas-derived ghrelinoma (PG-1) cells...
June 15, 2018: Scientific Reports
Ranka Kanda, Haruko Hiraike, Osamu Wada-Hiraike, Takayuki Ichinose, Kazunori Nagasaka, Yuko Sasajima, Eiji Ryo, Tomoyuki Fujii, Yutaka Osuga, Takuya Ayabe
BACKGROUND: A previous report showed that a glucagon-like peptide-1 receptor (GLP-1R) agonist (exenatide) induced apoptosis in endometrial cancer cells. However, the pathophysiological role of GLP-1R in endometrial cancer has not been fully elucidated. Here, we investigated the effects of the GLP-1R agonist liraglutide in endometrial cancer cells and examined the association between GLP-1R expression and clinicopathological characteristics in endometrial cancer patients. METHODS: Human Ishikawa endometrial cancer cells were treated with different concentrations of liraglutide...
June 15, 2018: BMC Cancer
Satoshi Oikawa, Shogo Wada, Minjung Lee, Seiji Maeda, Takayuki Akimoto
The capillary network is distributed throughout the body, and its reconstruction is induced under various pathophysiological conditions. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression via post-transcriptional mechanisms and are involved in many biological functions including angiogenesis. Previous studies have shown that each miRNA of the miR-23 cluster, composed of the miR-23a cluster (miR-23a~27a~24-2) and miR-23b cluster (miR-23b~27b~24-2), regulates angiogenesis in vitro. However, the role of the endothelium-specific miR-23 cluster, located within a single transcription unit, in angiogenesis in vivo has not been elucidated...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Yoshiaki Kumagai, Zoltan Jurek, Weiqing Xu, Hironobu Fukuzawa, Koji Motomura, Denys Iablonskyi, Kiyonobu Nagaya, Shin-Ichi Wada, Subhendu Mondal, Tetsuya Tachibana, Yuta Ito, Tsukasa Sakai, Kenji Matsunami, Toshiyuki Nishiyama, Takayuki Umemoto, Christophe Nicolas, Catalin Miron, Tadashi Togashi, Kanade Ogawa, Shigeki Owada, Kensuke Tono, Makina Yabashi, Sang-Kil Son, Beata Ziaja, Robin Santra, Kiyoshi Ueda
We show that electron and ion spectroscopy reveals the details of the oligomer formation in Ar clusters exposed to an x-ray free electron laser (XFEL) pulse, i.e., chemical dynamics triggered by x rays. With guidance from a dedicated molecular dynamics simulation tool, we find that van der Waals bonding, the oligomer formation mechanism, and charge transfer among the cluster constituents significantly affect ionization dynamics induced by an XFEL pulse of moderate fluence. Our results clearly demonstrate that XFEL pulses can be used not only to "damage and destroy" molecular assemblies but also to modify and transform their molecular structure...
June 1, 2018: Physical Review Letters
Isao Yada, Hiromi Wada, Masayuki Shinoda, Keishu Yasuda
The original publication of the articles cited above included incorrect values.
June 15, 2018: General Thoracic and Cardiovascular Surgery
R Tominaga-Wada, T Wada
Intercellular movement of transcription factor proteins is essential for plant development. The R3 type MYB transcription factor protein, CAPRICE (CPC), moves from non-hair cells to root-hair cells where it promotes root hair formation in Arabidopsis root epidermis. In contrast, the CPC homolog of ENHANCER OF TRY AND CPC1 (ETC1) cannot move in root epidermal cells. In this work, we present protein localization data of CPC-ETC1 chimeric proteins. Localization of CPC-ETC1-GFP fusion proteins of chimera1 and chimera2 transgenic plants was observed using confocal laser scanning microscope...
June 2018: Data in Brief
Yutaro Yamamoto, Nobuyoshi Sasaki, Kosuke Kumagai, Satoru Takeuchi, Terushige Toyooka, Naoki Otani, Kojiro Wada, Yoshitaka Narita, Koichi Ichimura, Hiroki Namba, Kentaro Mori, Arata Tomiyama
Glioblastoma (GBM) still carries a poor prognosis due to the refractoriness against antitumor drugs. Temozolomide (TMZ), one of the few standard therapy drugs against GBM worldwide, has only limited effect due to acquired TMZ resistance of GBM. Therefore, development of novel therapeutic methods to overcome the TMZ resistance of GBM is urgent. The brain is the most cholesterol-rich organ in the human body, so modulation of cholesterol in tumor cells originating from the brain including GBM may be a tumor-specific therapeutic strategy including enhancement of TMZ effects...
June 13, 2018: Neurologia Medico-chirurgica
Terunaga Inage, Takahiro Nakajima, Sakae Itoga, Takayuki Ishige, Taiki Fujiwara, Yuichi Sakairi, Hironobu Wada, Hidemi Suzuki, Takekazu Iwata, Masako Chiyo, Shigetoshi Yoshida, Kazuyuki Matsushita, Kazuhiro Yasufuku, Ichiro Yoshino
BACKGROUND: The limited negative predictive value of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has often been discussed. OBJECTIVE: The aim of this study was to identify a highly sensitive molecular biomarker for lymph node staging by EBUS-TBNA. METHODS: Five microRNAs (miRNAs) (miR-200a, miR-200b, miR-200c, miR-141, and let-7e) were selected as biomarker candidates for the detection of nodal metastasis in a miRNA expression analysis...
June 13, 2018: Respiration; International Review of Thoracic Diseases
Alexander J Hoffman, John W Finger, Haruka Wada
Developmental stressors can have strong effects that persist well into adulthood, and are generally seen as detrimental. However, recent work suggests that a mild developmental stressor can have beneficial effects by preparing the organism to better withstand negative impacts when exposed to high levels of the stressor later in life, also known as a conditioning hormesis. Still, little is known about the influence of such hormetic effects on fitness-related measures. We hypothesized that exposure to a mild stressor during development will protect individuals later in life from the negative effects of a high heat stressor on immune function and reproduction...
June 12, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
Hidemi Takeuchi, Haruhito A Uchida, Yuki Kakio, Yuka Okuyama, Michihiro Okuyama, Ryoko Umebayashi, Kentaro Wada, Hitoshi Sugiyama, Ken Sugimoto, Hiromi Rakugi, Jun Wada
The population undergoing dialysis is aging worldwide, particularly in Japan. The clinical condition of frailty is the most problematic expression in the elderly population. Potential pathophysiological factors of frailty present in patients with CKD and are accentuated in patients with ESRD. The aim of this study was to identify the prevalence and predictors of frailty in Japanese HD patients. This study was a multicenter, cross-sectional and observational investigation conducted at 6 institutions. To evaluate frailty, the modified Fried's frailty phenotype adjusted for Japanese as the self-reported questionnaire was used...
April 2018: Aging and Disease
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