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Cancer metabolomics

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https://www.readbyqxmd.com/read/29168171/the-arginine-metabolome-in-acute-lymphoblastic-leukemia-can-be-targeted-by-the-peg-recombinant-arginase-i-bct-100
#1
Carmela De Santo, Sarah Booth, Ashley Vardon, Antony Cousins, Vanessa Tubb, Tracey Perry, Boris Noyvert, Andrew Beggs, Margaret Ng, Christina Halsey, Pamela Kearns, Paul Cheng, Francis Mussai
Arginine is a semi-essential amino acid that plays a key role in cell survival and proliferation in normal and malignant cells. BCT-100, a pegylated recombinant human arginase, can deplete arginine and starve malignant cells of the amino acid. Acute Lymphoblastic Leukemia is the most common cancer of childhood, yet for patients with high risk or relapsed disease prognosis remains poor. We show that BCT-100 is cytotoxic to ALL blasts from patients in vitro by necrosis, and is synergistic in combination with dexamethasone...
November 23, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29166547/chemical-metabolome-assay-by-high-resolution-orbitrap-mass-spectrometry-and-assessment-of-associated-antitumoral-activity-of-actinocephalus-divaricatus
#2
Ana C Zanatta, Angela Mari, Milena Masullo, Iracilda Zeppone Carlos, Wagner Vilegas, Sonia Piacente, Lourdes Campaner Dos Santos
RATIONALE: Actinocephalus divaricatus (Eriocaulaceae) is an important source of income for the rural communities as it is sold as an ornamental plant. To date, no investigation has been conducted concerning the chemical composition and biological studies of the aerial parts of A. divaricatus. METHODS: The methanolic extract of the aerial parts of this species was chemically characterized. We applied an analytical dereplication approach based on Liquid Chromatography coupled to High Resolution Orbitrap Mass Spectrometry in order to develop, identify and define rapidly the metabolite fingerprint of the aerial parts of A...
November 22, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29162930/chemopreventive-effects-of-ku-jin-tea-against-aom-induced-precancerous-colorectal-lesions-in-rats-and-metabolomic-analysis
#3
Wu Bi, Haibo Liu, Jie Shen, Ling-Hua Zhang, Pei Li, Bing Peng, Li Cao, Pengfei Zhang, Chunnian He, Peigen Xiao
Ku-jin tea (KJT) is a health beverage prepared from the leaves of the plant Acer tataricum subsp. ginnala that has been consumed in some regions of China for thousands of years. KJT contains high levels of anti-inflammatory and antioxidative compounds such as ginnalins, but little is known about the chemopreventive effect of KJT on colon cancer. In this study, we investigated the preventive effects of KJT on colon carcinogenesis using the azoxymethane (AOM)-induced precancerous colorectal lesion model in rats...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29157273/effect-of-daikenchuto-tj-100-on-gastrointestinal-symptoms-following-laparoscopic-colectomy-in-patients-with-colon-cancer-study-protocol-for-a-randomized-controlled-trial
#4
Nobuaki Hoshino, Kenji Kawada, Koya Hida, Toshiaki Wada, Ryo Takahashi, Mami Yoshitomi, Yoshiharu Sakai
BACKGROUND: Postoperative paralytic ileus can be a difficult complication for both surgeons and patients. Causes and treatments have been discussed for more than two centuries, but have not yet been fully resolved. Daikenchuto (TJ-100, DKT) is a traditional Japanese herbal medicine. Recently, some beneficial mechanisms of DKT to relieve paralytic ileus have been reported. DKT can suppress inflammation, increase intestinal blood flow, and accelerate bowel movements. Therefore, we have designed a randomized controlled trial to investigate the effects of DKT on postoperative gastrointestinal symptoms following laparoscopic colectomy in patients with left-sided colon cancer at a single institution...
November 21, 2017: Trials
https://www.readbyqxmd.com/read/29156692/increased-transcriptional-and-metabolic-capacity-for-lipid-metabolism-in-the-peripheral-zone-of-the-prostate-may-underpin-its-increased-susceptibility-to-cancer
#5
Omar Al Kadhi, Maria H Traka, Antonietta Melchini, Perla Troncoso-Rey, Wiktor Jurkowski, Marianne Defernez, Purnima Pachori, Robert D Mills, Richard Y Ball, Richard F Mithen
The human prostate gland comprises three distinct anatomical glandular zones, namely the peripheral, central and transitional zones. Although prostate cancer can arise throughout the prostate, it is more frequent in the peripheral zone. In contrast, hyperplasia occurs most frequently in the transitional zone. In this paper, we test the hypothesis that peripheral and transitional zones have distinct metabolic adaptations that may underlie their different inherent predispositions to cancer and hyperplasia. In order to do this, we undertook RNA sequencing and high-throughput metabolic analyses of non-cancerous tissue from the peripheral and transitional zones of patients undergoing prostatectomy...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29152916/serum-and-urine-metabolomics-study-reveals-a-distinct-diagnostic-model-for-cancer-cachexia
#6
Quan-Jun Yang, Jiang-Rong Zhao, Juan Hao, Bin Li, Yan Huo, Yong-Long Han, Li-Li Wan, Jie Li, Jinlu Huang, Jin Lu, Gen-Jin Yang, Cheng Guo
BACKGROUND: Cachexia is a multifactorial metabolic syndrome with high morbidity and mortality in patients with advanced cancer. The diagnosis of cancer cachexia depends on objective measures of clinical symptoms and a history of weight loss, which lag behind disease progression and have limited utility for the early diagnosis of cancer cachexia. In this study, we performed a nuclear magnetic resonance-based metabolomics analysis to reveal the metabolic profile of cancer cachexia and establish a diagnostic model...
November 19, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29151921/linking-gut-microbiota-to-colorectal-cancer
#7
REVIEW
Hans Raskov, Jakob Burcharth, Hans-Christian Pommergaard
Pre-clinical and clinical data produce mounting evidence that the microbiota is strongly associated with colorectal carcinogenesis. Dysbiosis may change the course of carcinogenesis as microbial actions seem to impact genetic and epigenetic alterations leading to dysplasia, clonal expansion and malignant transformation. Initiation and promotion of colorectal cancer may result from direct bacterial actions, bacterial metabolites and inflammatory pathways. Newer aspects of microbiota and colorectal cancer include quorum sensing, biofilm formation, sidedness and effects/countereffects of microbiota and probiotics on chemotherapy...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29150352/dysregulation-of-mrna-translation-and-energy-metabolism-in-cancer
#8
REVIEW
Matthew Leibovitch, Ivan Topisirovic
Dysregulated mRNA translation and aberrant energy metabolism are frequent in cancer. Considering that mRNA translation is an energy demanding process, cancer cells must produce sufficient ATP to meet energy demand of hyperactive translational machinery. In recent years, the mammalian/mechanistic target of rapamycin (mTOR) emerged as a central regulatory node which coordinates energy consumption by the translation apparatus and ATP production in mitochondria. Aberrant mTOR signaling underpins the vast majority of cancers whereby increased mTOR activity is thought to be a major determinant of both malignant translatomes and metabolomes...
November 2, 2017: Advances in Biological Regulation
https://www.readbyqxmd.com/read/29144383/monitoring-for-response-to-antineoplastic-drugs-the-potential-of-a-metabolomic-approach
#9
REVIEW
Jodi Rattner, Oliver F Bathe
For most cancers, chemotherapeutic options are rapidly expanding, providing the oncologist with substantial choices. Therefore, there is a growing need to select the best systemic therapy, for any individual, that effectively halts tumor progression with minimal toxicity. Having the capability to predict benefit and to anticipate toxicity would be ideal, but remains elusive at this time. An alternative approach is an adaptive approach that involves close observation for treatment response and emergence of resistance...
November 16, 2017: Metabolites
https://www.readbyqxmd.com/read/29143101/candidate-biomarkers-in-the-cervical-vaginal-fluid-for-the-self-diagnosis-of-cervical-precancer
#10
REVIEW
Xaveer Van Ostade, Martin Dom, Wiebren Tjalma, Geert Van Raemdonck
PURPOSE: Despite improvement in vaccines against human papilloma virus (HPV), the causative agent of cervical cancer, screening women for cervical precancer will remain indispensable in the coming 30-40 years. A simple test that could be performed at home or at a doctor's practice and that informs the woman whether she is at risk would significantly help make a broader group of patients who aware that they need medical treatment. Cervical vaginal fluid (CVF) is a body fluid that is very well suited for such a test...
November 15, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29142749/urine-metabolomics-as-a-predictor-of-patient-tolerance-and-response-to-adjuvant-chemotherapy-in-colorectal-cancer
#11
Mark A Dykstra, Noah Switzer, Roman Eisner, Victor Tso, Rae Foshaug, Kathleen Ismond, Richard Fedorak, Haili Wang
Colorectal cancer is the third leading cause of cancer-associated mortality in the western world. The ability to predict a patient's response to chemotherapy may be of great value for clinicians and patients when planning cancer treatment. The aim of the current study was to develop a urine metabolomics-based biomarker panel to predict adverse events and response to chemotherapy in patients with colorectal cancer. A retrospective chart review of patients diagnosed with stage III or IV colorectal cancer between 2008 and 2012 was performed...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29138896/-metabolomics-and-cancer
#12
M Schwab, P Fisel, E Schäffeler
No abstract text is available yet for this article.
November 14, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29137365/longitudinal-serum-metabolomics-evaluation-of-trastuzumab-and-everolimus-combination-as-pre-operative-treatment-for-her-2-positive-breast-cancer-patients
#13
Elodie Jobard, Olivier Trédan, Thomas Bachelot, Arnaud M Vigneron, Céline Mahier Aït-Oukhatar, Monica Arnedos, Maria Rios, Jacques Bonneterre, Véronique Diéras, Marta Jimenez, Jean-Louis Merlin, Mario Campone, Bénédicte Elena-Herrmann
The mammalian target of rapamycin complex 1 (mTORC1) is an attractive target for HER-2 positive breast cancer therapy because of its key role in protein translation regulation, cell growth and metabolism. We present here a metabolomic investigation exploring the impact of mTOR inhibition on serum metabolic profiles from patients with non-metastatic breast cancer overexpressing HER-2. Baseline, treatment-related and post-treatment serum samples were analyzed for 79 patients participating in the French clinical trial RADHER, in which randomized patients with HER-2 positive breast cancer received either trastuzumab alone (arm T) or a trastuzumab and everolimus combination (arm T+E)...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137232/integration-of-metabolomics-transcriptomics-and-microrna-expression-profiling-reveals-a-mir-143-hk2-glucose-network-underlying-zinc-deficiency-associated-esophageal-neoplasia
#14
Louise Y Fong, Ruiyan Jing, Karl J Smalley, Cristian Taccioli, Johannes Fahrmann, Dinesh K Barupal, Hansjuerg Alder, John L Farber, Oliver Fiehn, Carlo M Croce
Esophageal squamous cell carcinoma (ESCC) in humans is a deadly disease associated with dietary zinc (Zn)-deficiency. In the rat esophagus, Zn-deficiency induces cell proliferation, alters mRNA and microRNA gene expression, and promotes ESCC. We investigated whether Zn-deficiency alters cell metabolism by evaluating metabolomic profiles of esophageal epithelia from Zn-deficient and replenished rats vs sufficient rats, using untargeted gas chromatography time-of-flight mass spectrometry (n = 8/group). The Zn-deficient proliferative esophagus exhibits a distinct metabolic profile with glucose down 153-fold and lactic acid up 1...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29125557/early-response-monitoring-following-radiation-therapy-by-using-18-f-fdg-and-11-c-acetate-pet-in-prostate-cancer-xenograft-model-with-metabolomics-corroboration
#15
Yi-Hsiu Chung, Cheng-Kun Tsai, Chiun-Chieh Wang, Hsi-Mu Chen, Kuan-Ying Lu, Han Chiu, Yu-Chun Lin, Tzu-Chen Yen, Gigin Lin
We aim to characterize the metabolic changes associated with early response to radiation therapy in a prostate cancer mouse model by 2-deoxy-2-[(18)F]fluoro-d-glucose ([(18)F]FDG) and [(11)C]acetate ([(11)C]ACT) positron emission tomography, with nuclear magnetic resonance (NMR) metabolomics corroboration. [(18)F]FDG and [(11)C]ACT PET were performed before and following irradiation (RT, 15Gy) for transgenic adenocarcinoma of mouse prostate xenografts. The underlying metabolomics alterations of tumor tissues were analyzed by using ex vivo NMR...
November 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29120399/a-microbiomic-analysis-in-african-americans-with-colonic-lesions-reveals-streptococcus-sp-vt162-as-a-marker-of-neoplastic-transformation
#16
Hassan Brim, Shibu Yooseph, Edward Lee, Zaki Sherif, Muneer Abbas, Adeyinka O Laiyemo, Sudhir Varma, Manolito Torralba, Scot E Dowd, Karen E Nelson, Wimal Pathmasiri, Susan Sumner, Willem de Vos, Qiaoyi Liang, Jun Yu, Erwin Zoetendal, Hassan Ashktorab
Increasing evidence suggests a role of the gut microbiota in colorectal carcinogenesis (CRC). To detect bacterial markers of colorectal cancer in African Americans a metabolomic analysis was performed on fecal water extracts. DNA from stool samples of adenoma and healthy subjects and from colon cancer and matched normal tissues was analyzed to determine the microbiota composition (using 16S rDNA) and genomic content (metagenomics). Metagenomic functions with discriminative power between healthy and neoplastic specimens were established...
November 9, 2017: Genes
https://www.readbyqxmd.com/read/29119730/nuclear-magnetic-resonance-spectroscopy-as-a-new-approach-for-improvement-of-early-diagnosis-and-risk-stratification-of-prostate-cancer
#17
Bo Yang, Guo-Qiang Liao, Xiao-Fei Wen, Wei-Hua Chen, Sheng Cheng, Jens-Uwe Stolzenburg, Roman Ganzer, Jochen Neuhaus
Prostate cancer (PCa) is the second most common male cancer worldwide and the fifth leading cause of death from cancer in men. Early detection and risk stratification is the most effective way to improve the survival of PCa patients. Current PCa biomarkers lack sufficient sensitivity and specificity to cancer. Metabolite biomarkers are evolving as a new diagnostic tool. This review is aimed to evaluate the potential of metabolite biomarkers for early detection, risk assessment, and monitoring of PCa. Of the 154 identified publications, 27 and 38 were original papers on urine and serum metabolomics, respectively...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/29117588/metabolic-profiling-on-the-effect-of-2-2-4-4-tetrabromodiphenyl-ether-bde-47-in-mcf-7%C3%A2-cells
#18
Juntong Wei, Li Xiang, Zigao Yuan, Shangfu Li, Chunxue Yang, Hongxia Liu, Yuyang Jiang, Zongwei Cai
Polybrominated diphenyl ethers (PBDEs) are commonly used to prevent the development of fire in various factory products. Due to the adverse effects on human health and the bio-accumulation capacity, PBDEs are considered as one kind of persistent organic pollutants (POPs). BDE-47 is one of the most frequently detected PBDEs congeners in human samples. Although numerous studies have shown the close connection between BDE-47 and human health, few reports were related to breast carcinoma. In the present study, the toxicity mechanism of BDE-47 was investigated by using MCF-7 breast cancer cells...
October 31, 2017: Chemosphere
https://www.readbyqxmd.com/read/29114178/cancer-metabolism-and-tumor-heterogeneity-imaging-perspectives-using-mr-imaging-and-spectroscopy
#19
REVIEW
Gigin Lin, Kayvan R Keshari, Jae Mo Park
Cancer cells reprogram their metabolism to maintain viability via genetic mutations and epigenetic alterations, expressing overall dynamic heterogeneity. The complex relaxation mechanisms of nuclear spins provide unique and convertible tissue contrasts, making magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) pertinent imaging tools in both clinics and research. In this review, we summarized MR methods that visualize tumor characteristics and its metabolic phenotypes on an anatomical, microvascular, microstructural, microenvironmental, and metabolomics scale...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29110627/the-impact-of-translational-research-in-breast-cancer-care-can-we-improve-the-therapeutic-scenario
#20
Francesco Perri, Giuseppe Buono, Francesco Schettini, Grazia Arpino, Roberto Bianco, Carmen Criscitiello, Sabino De Placido, Mario Giuliano
Traditionally, breast cancer (BC) is divided into different immunohistochemically (IHC)-defined subtypes, according to the expression of hormone receptors and overexpression/amplification of human epidermal growth factor receptor 2 (HER2), with crucial therapeutic implications. In the last few years, the definition of different BC molecular subgroups within the IHC-defined subtypes and the identification of the important role that molecular heterogeneity can play in tumor progression and treatment resistance have inspired the search for personalized therapeutic approaches...
November 2, 2017: Anti-cancer Agents in Medicinal Chemistry
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