keyword
https://read.qxmd.com/read/38526821/steamed-daylily-flower-hemerocallis-fulva-l-protected-cardiac-and-hepatic-cells-against-ethanol-induced-apoptotic-and-oxidative-damage
#1
JOURNAL ARTICLE
Sheng-Lei Yan, Wen-Tzu Wu, Mei-Chin Mong, Mei-Chin Yin
Our previous study examined the phytochemical composition and bio-activities of raw daylily flower (Hemerocallis fulva L.). However, this plant food is usually served via heat process such as cooking in a soup. This study aimed to investigate the phytochemical profile and biofunctions of steamed daylily flower (SDF). The content of total phenolic acids, total flavonoids, total carotenoids, total anthocyanins and total triterpenoids in SDF aqueous extract was assessed. Normal cardiac and hepatic cells, H9c2 and L-02 cells, were used to evaluate the protective effects of SDF against ethanol...
December 15, 2023: Journal of Food and Drug Analysis
https://read.qxmd.com/read/38526135/sirt3-mediates-the-cardioprotective-effect-of-therapeutic-hypothermia-after-cardiac-arrest-and-resuscitation-by-restoring-autophagic-flux-via-the-pi3k-akt-mtor-pathway
#2
JOURNAL ARTICLE
Hui Wang, Wenwen Wang, Zhiwei Xue, Huiping Gong
BACKGROUND: Postresuscitation cardiac dysfunction is a significant contributor to early death following cardiopulmonary resuscitation (CPR). Therapeutic hypothermia (TH) mitigates myocardial dysfunction due to cardiac arrest (CA); however, the underlying mechanism remains unclear. Sirtuin 3 (Sirt3) was found to affect autophagic activity in recent research, motivating us to investigate its role in the cardioprotective effects of TH in the treatment of CA. METHODS: Sprague-Dawley rats were used to establish an in vivo CA/CPR model and treated with a selective Sirt3 inhibitor or vehicle...
March 25, 2024: Shock
https://read.qxmd.com/read/38522871/late-pulmonary-autograft-dilation-can-we-make-a-good-operation-great-the-tailored-approach
#3
REVIEW
Ismail El-Hamamsy, Luca A Vricella
While it is the main viable option in the growing child and young adult, the Ross procedure has expanded its applicability to older patients, for whom long-term results are equivalent, if not superior, to prosthetic aortic valve replacement. Strategies aiming at mitigating long-term autograft failure from root enlargement and valve regurgitation have led some to advocate for root reinforcement with prosthetic graft material. On the contrary, we will discuss herein the rationale for a tailored approach to the Ross procedure; this strategy is aimed at maintaining the natural physiology and interplay between the various autograft components...
2024: Seminars in Thoracic and Cardiovascular Surgery. Pediatric Cardiac Surgery Annual
https://read.qxmd.com/read/38520533/early-microvascular-coronary-endothelial-dysfunction-precedes-pembrolizumab-induced-cardiotoxicity-preventive-role-of-high-dose-of-atorvastatin
#4
JOURNAL ARTICLE
Panagiotis Efentakis, Angeliki Choustoulaki, Grzegorz Kwiatkowski, Aimilia Varela, Ioannis V Kostopoulos, George Tsekenis, Ioannis Ntanasis-Stathopoulos, Anastasios Georgoulis, Constantinos E Vorgias, Harikleia Gakiopoulou, Alexandros Briasoulis, Constantinos H Davos, Nikolaos Kostomitsopoulos, Ourania Tsitsilonis, Meletios Athanasios Dimopoulos, Evangelos Terpos, Stefan Chłopicki, Maria Gavriatopoulou, Ioanna Andreadou
Immune checkpoint inhibitors (ICIs) exhibit remarkable antitumor activity and immune-related cardiotoxicity of unknown pathomechanism. The aim of the study was to investigate the ICI class-dependent cardiotoxicity in vitro and pembrolizumab's (Pem's) cardiotoxicity in vivo, seeking for translational prevention means. Cytotoxicity was investigated in primary cardiomyocytes and splenocytes, incubated with ipilimumab, Pem and avelumab. Pem's cross-reactivity was assessed by circular dichroism (CD) on biotechnologically produced human and murine PD-1 and in silico...
March 23, 2024: Basic Research in Cardiology
https://read.qxmd.com/read/38517263/reduced-cx43-expression-induces-autophagy-through-activation-of-the-ampk-mtor-ulk1-signaling-pathway-in-the-common-bile-duct-ligation-rat-heart
#5
JOURNAL ARTICLE
Xiaoyu Wang, Pingping Liao, He Dong, Aijie Liu, Qian Wang, Han Yang, Xiaolin Xu, Dongyue Chai, Lin Zhu, Lin Lyu
BACKGROUNDS: This study aimed to investigate the relationship between Cx43 expression and autophagy mediated by the AMPK-mTOR-Ulk1 signaling pathway in jaundice heart. METHODS: In this study, a jaundice model was established in common bile duct ligation (CBDL) rats. Cardiac injury was assessed using various methods including myocardial injury indicators, echocardiography, TEM, HE staining, Masson staining, IHC, and IF. We investigated the regulatory relationship between Cx43, autophagy, and the AMPK-mTOR-ULK pathway in vivo by administering autophagy agonists (Rapa), autophagy inhibitors (3-MA), and Cx43 inhibitors (Gap 26)...
March 13, 2024: Shock
https://read.qxmd.com/read/38516693/endovascular-transplantation-of-mrna-enhanced-mesenchymal-stromal-cells-results-in-superior-therapeutic-protein-expression-in-swine-heart
#6
JOURNAL ARTICLE
Jonathan Al-Saadi, Mathias Waldén, Mikael Sandell, Jesper Sohlmér, Rikard Grankvist, Ida Friberger, Agneta Andersson, Mattias Carlsten, Kenneth Chien, Johan Lundberg, Nevin Witman, Staffan Holmin
Heart failure has a poor prognosis and no curative treatment exists. Clinical trials are investigating gene- and cell-based therapies to improve cardiac function. The safe and efficient delivery of these therapies to solid organs is challenging. Herein, we demonstrate the feasibility of using an endovascular intramyocardial delivery approach to safely administer mRNA drug products and perform cell transplantation procedures in swine. Using a trans -vessel wall (TW) device, we delivered chemically modified mRNAs (modRNA) and mRNA-enhanced mesenchymal stromal cells expressing vascular endothelial growth factor A (VEGF-A) directly to the heart...
June 13, 2024: Molecular Therapy. Methods & Clinical Development
https://read.qxmd.com/read/38516005/hybrid-stage-1-palliation-for-hlhs-the-experience-of-a-tertiary-center-in-a-developing-country
#7
JOURNAL ARTICLE
Fouad Bitar, Issam M El-Rassi, Rana Zareef, Yehya Jassar, Jennifer Abboud, Ziad Bulbul, Fadi Bitar, Mariam Arabi
BACKGROUND: Hypoplastic left heart syndrome (HLHS) accounts for 2.6% of congenital heart disease and is an invariably fatal cardiac anomaly if left untreated. Approximately 33,750 babies are born annually with HLHS in developing countries. Unfortunately, the majority will not survive due to the scarcity of resources and the limited availability of surgical management. AIM: To describe and analyze our experience with the hybrid approach in the management of HLHS in a developing country...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38513595/maximakinin-reversed-h-2-o-2-induced-oxidative-damage-in-rat-cardiac-h9c2-cells-through-ampk-akt-and-ampk-erk1-2-signaling-pathways
#8
JOURNAL ARTICLE
Yang Yu, Fan-Fan Su, Cheng Xu
Maximakinin (MK), a homolog of bradykinin (BK), is extracted from skin venom of the Chinese toad Bombina maxima. Although MK has a good antihypertensive effect, its effect on myocardial cells is unclear. This study investigates the protective effect of MK on hydrogen peroxide (H2 O2 )-induced oxidative damage in rat cardiac H9c2 cells and explores its mechanism of action. A 3-(4,5-Dimethyl-2-Thiazolyl)-2,5-Diphenyl Tetrazolium Bromide (MTT) assay was selected to detect the effect of MK on H9c2 cell viability, while flow cytometry was used to investigate the influence of MK and H2 O2 on intracellular reactive oxygen species (ROS) levels...
March 20, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38506743/ischaemic-and-viability-testing-for-guiding-pci-are-overrated-pros%C3%A2-and-cons
#9
JOURNAL ARTICLE
Margaret B McEntegart, Anja Oksnes, Xavier Carrillo, Victoria Delgado
No abstract text is available yet for this article.
March 18, 2024: EuroIntervention
https://read.qxmd.com/read/38502970/the-impact-of-diabetic-glucose-concentration-on-viability-and-cardiac-differentiation-of-mesenchymal-stem-cells
#10
JOURNAL ARTICLE
Shadi Nosrati, Maryam Gheisari, Shahrokh Zare, Mahintaj Dara, Samaneh Zolghadri, Iman Razeghian-Jahromi
INTRODUCTION: Hyperglycemia may be a stumbling block for delivery of regenerative benefits of mesenchymal stem cells (MSCs) to diabetic patients with cardiovascular diseases. Our study aims to assess the viability and cardiac differentiation potential of MSCs after being exposed to diabetic glucose concentration. METHODS: MSCs were extracted from rat bone marrow. Cells were characterized based on morphology, differentiation potential, and expression of mesenchymal specific markers...
March 16, 2024: Tissue & Cell
https://read.qxmd.com/read/38501407/-colchicine-alleviates-myocardial-ischemia-reperfusion-injury-in-mice-by-activating-ampk
#11
JOURNAL ARTICLE
G Chen, S Luo
OBJECTIVE: To investigate the protective effect of colchicine against myocardial ischemia-reperfusion injury (I/R) and explore the underlying mechanism. METHODS: H9C2 cells exposed to hypoxia/reoxygenation (H/R) were treated with 3 nmol/L colchicine, after which the changes in cell viability were assessed using MTT assay, and AMPK phosphorylation, the expressions of NOX4, NRF2, SOD2, BAX, Bcl-2, and cleaved caspase-3 were detected with Western blotting. Male C57BL/6 mice were randomized into sham operation, I/R, I/R+colchicine, and I/R+colchicine+dorsomorphin (DSMP) groups...
February 20, 2024: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://read.qxmd.com/read/38499110/plce1-enhances-mitochondrial-dysfunction-to-promote-gsdme-mediated-pyroptosis-in-doxorubicin-induced-cardiotoxicity
#12
JOURNAL ARTICLE
Maierhaba Tuersuntuoheti, Fei Peng, Juexing Li, Lei Zhou, Hailan Gao, Hui Gong
BACKGROUND: The therapeutic value and long-term application of doxorubicin (DOX) were hampered by its severe irreversible cardiotoxicity. Phospholipase C epsilon 1 (PLCE 1) was reported as a new member of the phospholipase C (PLC) family which controls the level of phosphoinositides in cells. Pyroptosis is a newly discovered inflammatory type of regulated cell death. Recent studies have consolidated that chemotherapeutic drugs lead to pyroptosis. Additionally, the phosphoinositide signaling system has remarkable effects on the execution of cell death...
March 16, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38496011/improving-cardiac-differentiation-of-human-pluripotent-stem-cells-by-targeting-ferroptosis
#13
JOURNAL ARTICLE
Jeffrey Aalders, Laurens Léger, Behrouz Hassannia, Vera Goossens, Tom Vanden Berghe, Jolanda van Hengel
Generation of cardiomyocytes from human pluripotent stem cells (hPSCs) is of high interest for disease modelling and regenerative medicine. hPSCs can provide an unlimited source of patient-specific cardiomyocytes that are otherwise difficult to obtain from individuals. Moreover, the low proliferation rate of adult cardiomyocytes and low viability ex vivo limits the quantity of study material. Most protocols for the differentiation of cardiomyocytes from hPSCs are based on the temporal modulation of the Wnt pathway...
December 2024: Regenerative Therapy
https://read.qxmd.com/read/38485921/network-pharmacology-prediction-molecular-docking-and-in-vitro-experiment-explored-the-potential-mechanism-of-gaoyuan-an-capsule-in-improving-hypoxia-tolerance
#14
JOURNAL ARTICLE
Tianbo Jin, Xiaoli Liu, Yuhe Wang, Yijin Qi, Xuemei Li, Li Wang, Xue He
BACKGROUND: Tibetan medicine Gaoyuan'an capsule (GYAC) is widely used to prevent pulmonary edema at high altitude, but the specific mechanism has not been explored. In this study, we analyzed the mechanism of GYAC in hypoxia tolerance, and provided a new idea for the prevention and treatment of altitude disease. METHODS: The effective components and corresponding targets of GYAC were screened out by the Chinese herbal medicine network database, and the key targets of hypoxia tolerance were retrieved by Genecards, OMIM and PubMed database...
March 14, 2024: Pharmacogenomics Journal
https://read.qxmd.com/read/38485345/effects-of-d-allose-on-atp-production-and-cell-viability-in-neonatal-rat-cardiomyocytes
#15
JOURNAL ARTICLE
Xi Chen, Asadur Rahman, Steeve Akumwami, Asahiro Morishita, Kento Kitada, Yasumasa Ikeda, Masafumi Funamoto, Akira Nishiyama
2-Deoxy-d-glucose (2DG) induces anticancer effects through glycolytic inhibition but it may raise the risk of arrhythmia. The rare monosaccharide d-allose also has anticancer properties, but its cardiac effects are unknown. We examined the effects of d-allose on adenosine triphosphate (ATP) production in neonatal rat cardiomyocytes. We showed that 25 mM d-allose selectively reduced glycolytic ATP, but had minimal impact on mitochondrial ATP, while 1 mM 2DG strongly inhibited both. Furthermore, d-allose had less impact on cell viability and was less cytotoxic than 2DG; neither compound caused apoptosis...
April 2024: Journal of Pharmacological Sciences
https://read.qxmd.com/read/38483109/normothermic-machine-perfusion-for-liver-transplantation-current-state-and-future-directions
#16
JOURNAL ARTICLE
Jessica Lindemann, Jennifer Yu, Mb Majella Doyle
PURPOSE OF REVIEW: The number of patients on the liver transplant waitlist continues to grow and far exceeds the number of livers available for transplantation. Normothermic machine perfusion (NMP) allows for ex-vivo perfusion under physiologic conditions with the potential to significantly increase organ yield and expand the donor pool. RECENT FINDINGS: Several studies have found increased utilization of donation after cardiac death and extended criteria brain-dead donor livers with implementation of NMP, largely due to the ability to perform viability testing during machine perfusion...
March 15, 2024: Current Opinion in Organ Transplantation
https://read.qxmd.com/read/38472369/morroniside-improves-angii-induced-cardiac-fibroblast-proliferation-migration-and-extracellular-matrix-deposition-by-blocking-p38-jnk-signaling-pathway-through-the-downregulation-of-klf5
#17
JOURNAL ARTICLE
Haotian Zheng, Linxin Yang, Huashang Huang, Yazhou Lin, Lin Chen
Myocardial fibrosis (MF), which is an inevitable pathological manifestation of many cardiovascular diseases in the terminal stage, often contributes to severe cardiac dysfunction and sudden death. Morroniside (MOR) is the main active component of Cornus officinalis with a variety of biological activities. This study was designed to explore the efficacy of MOR in MF and to investigate its pharmacological mechanism. The viability of MOR-treated human cardiac fibroblast (HCF) cells with or without Angiotensin II (AngII) induction was assessed with Cell Counting Kit-8 (CCK-8)...
March 12, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38464269/efficient-and-reproducible-generation-of-human-ipsc-derived-cardiomyocytes-using-a-stirred-bioreactor
#18
Maksymilian Prondzynski, Raul H Bortolin, Paul Berkson, Michael A Trembley, Kevin Shani, Mason E Sweat, Joshua Mayourian, Albert M Cordoves, Nnaemeka J Anyanwu, Yashasvi Tharani, Justin Cotton, Joseph B Milosh, David Walker, Yan Zhang, Fujian Liu, Xujie Liu, Kevin K Parker, Vassilios J Bezzerides, William T Pu
In the last decade human iPSC-derived cardiomyocytes (hiPSC-CMs) proved to be valuable for cardiac disease modeling and cardiac regeneration, yet challenges with scale, quality, inter-batch consistency, and cryopreservation remain, reducing experimental reproducibility and limiting clinical translation. Here, we report a robust cardiac differentiation protocol that uses Wnt modulation and a stirred suspension bioreactor to produce on average 124 million hiPSC-CMs with >90% purity using a variety of hiPSC lines (19 differentiations; 10 iPSC lines)...
February 28, 2024: bioRxiv
https://read.qxmd.com/read/38459752/protective-effect-of-thymoquinone-nanoemulsion-in-reducing-the-cardiotoxic-effect-of-5-fluorouracil-in-rats
#19
JOURNAL ARTICLE
Bardia Karim, Motahare Arabameri, Fatemeh Alimoradi, Razieh Mansoori, Ali A Moghadamnia, Sohrab Kazemi, Seyed M Hosseini
5-Fluorouracil (5-FU), which is one of the most widely used chemotherapy drugs, has various side effects on the heart. Thymoquinone (TMQ), the main bioactive component of Nigella sativa, has antioxidant and protective effects against toxicity. In this study, we investigated the protective effect of thymoquinone against cardiotoxicity caused by 5-FU in vitro and in vivo models. H9C2 cells were exposed to 5-FU and TMQ, and cell viability was evaluated in their presence. Also, 25 male Wistar rats were divided into five control groups, 5-FU, 2...
April 2024: Drug Development Research
https://read.qxmd.com/read/38456539/rich1-is-a-novel-key-suppressor-of-isoproterenol%C3%A2-or-angiotensin-ii%C3%A2-induced-cardiomyocyte-hypertrophy
#20
JOURNAL ARTICLE
Siqi Wang, Xin Wang, Li Ling, Cairong Li, Zhanhong Ren
Cardiac hypertrophy is one of the key processes in the development of heart failure. Notably, small GTPases and GTPase‑activating proteins (GAPs) serve essential roles in cardiac hypertrophy. RhoGAP interacting with CIP4 homologs protein 1 (RICH1) is a RhoGAP that can regulate Cdc42/Rac1 and F‑actin dynamics. RICH1 is involved in cell proliferation and adhesion; however, to the best of our knowledge, its role in cardiac hypertrophy remains unknown. In the present study, the role of RICH1 in cardiomyocyte hypertrophy was assessed...
May 2024: Molecular Medicine Reports
keyword
keyword
18272
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.