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Cardiac viability

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https://www.readbyqxmd.com/read/28654385/3d-fusion-framework-for-infarction-and-angiogenesis-analysis-in-a-myocardial-infarct-minipig-model
#1
Xu Zhenzhen, Bo Tao, Yu Li, Jun Zhang, Xiaochao Qu, Feng Cao, Jimin Liang
The combination of different modality images can provide detailed and comprehensive information for the prognostic assessment and therapeutic strategy of patients with ischemic heart disease. In this study, a 3D fusion framework is designed to integrate coronary computed tomography (CT) angiography (CTA), 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]DG) positron emission tomography (PET)/CT, and [(68)Ga]-1,4,7-triazacyclononane-1,4,7-triacetic acid-(Arg-Gly-Asp)2 ([(68)Ga]-NOTA-PRGD2) PET/CT images of the myocardial infarction model in minipigs...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28645959/formal-consensus-to-identify-clinically-important-changes-in-management-resulting-from-the-use-of-cardiovascular-magnetic-resonance-cmr-in-patients-who-activate-the-primary-percutaneous-coronary-intervention-ppci-pathway
#2
Maria Pufulete, Rachel C Brierley, Chiara Bucciarelli-Ducci, John P Greenwood, Stephen Dorman, Richard A Anderson, Jessica Harris, Elisa McAlindon, Chris A Rogers, Barnaby C Reeves
OBJECTIVE: To define important changes in management arising from the use of cardiovascular magnetic resonance (CMR) in patients who activate the primary percutaneous coronary intervention (PPCI) pathway. DESIGN: Formal consensus study using literature review and cardiologist expert opinion to formulate consensus statements and setting up a consensus panel to review the statements (by completing a web-based survey, attending a face-to-face meeting to discuss survey results and modify the survey to reflect group discussion and completing the modified survey to determine which statements were in consensus)...
June 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/28642708/myricitrin-protects-cardiomyocytes-from-hypoxia-reoxygenation-injury-involvement-of-heat-shock-protein-90
#3
Min Wang, Gui-Bo Sun, Yu-Yang Du, Yu Tian, Ping Liao, Xue-Song Liu, Jing-Xue Ye, Xiao-Bo Sun
Modulation of oxidative stress is therapeutically effective in ischemia/reperfusion (I/R) injury. Myricitrin, a naturally occurring phenolic compound, is a potent antioxidant. However, little is known about its effect on I/R injury to cardiac myocytes. The present study was performed to investigate the potential protective effect of myricitrin against hypoxia/reoxygenation (H/R)-induced H9c2 cardiomyocyte injury and its underlying mechanisms. Myricitrin pretreatment improved cardiomyocyte viability, inhibited ROS generation, maintained the mitochondrial membrane potential, reduced apoptotic cardiomyocytes, decreased the caspase-3 activity, upregulated antiapoptotic proteins and downregulated proapoptotic proteins during H/R injury...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28641008/hypoxia-induced-changes-in-the-fibroblast-secretome-exosome-and-whole-cell-proteome-using-cultured-cardiac-derived-cells-isolated-from-neonatal-mice
#4
Jake Cosme, Hongbo Guo, Sina Hadipour-Lakmehsari, Andrew Emili, Anthony O Gramolini
Cardiac fibroblasts (CF) represent a major subpopulation of cells in the developing and adult heart. Cardiomyocyte (CM) and CF intercellular communication occurs through paracrine interactions and modulate myocyte development and stress response. Detailed proteomic analysis of the CF secretome in normal and stressed conditions may offer insights into the role of CF in heart development and disease. Primary neonatal mouse CF were isolated and cultured for 24h in 21% (normoxic) or 2% (hypoxic) O2. Conditioned media was separated to obtain EXO and EXO-depleted secretome fractions...
June 22, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28638829/mitochondrial-targeted-molecular-imaging-in-cardiac-disease
#5
REVIEW
Jinhui Li, Jing Lu, You Zhou
The present study aimed to discuss the role of mitochondrion in cardiac function and disease. The mitochondrion plays a fundamental role in cellular processes ranging from metabolism to apoptosis. The mitochondrial-targeted molecular imaging could potentially illustrate changes in global and regional cardiac dysfunction. The collective changes that occur in mitochondrial-targeted molecular imaging probes have been widely explored and developed. As probes currently used in the preclinical setting still have a lot of shortcomings, the development of myocardial metabolic activity, viability, perfusion, and blood flow molecular imaging probes holds great potential for accurately evaluating the myocardial viability and functional reserve...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28638482/implantable-and-biodegradable-macroporous-iron-oxide-frameworks-for-efficient-regeneration-and-repair-of-infracted-heart
#6
Wenshuo Wang, Hongyue Tao, Yun Zhao, Xiaotian Sun, Jing Tang, Cordelia Selomulya, Jia Tang, Tianchan Chen, Yang Wang, Minglei Shu, Lei Wei, Guanyu Yi, Jixue Zhou, Lai Wei, Chunsheng Wang, Biao Kong
The construction, characterization and surgical application of a multilayered iron oxide-based macroporous composite framework were reported in this study. The framework consisted of a highly porous iron oxide core, a gelatin-based hydrogel intermediary layer and a matrigel outer cover, which conferred a multitude of desirable properties including excellent biocompatibility, improved mechanical strength and controlled biodegradability. The large pore sizes and high extent of pore interconnectivity of the framework stimulated robust neovascularization and resulted in substantially better cell viability and proliferation as a result of improved transport efficiency for oxygen and nutrients...
2017: Theranostics
https://www.readbyqxmd.com/read/28631080/comparison-of-volumetric-and-functional-parameters-in-simultaneous-cardiac-pet-mr-feasibility-of-volumetric-assessment-with-residual-activity-from-prior-pet-ct
#7
C Lücke, B Oppolzer, P Werner, B Foldyna, P Lurz, T Jochimsen, B Brenneis, L Lehmkuhl, B Sattler, M Grothoff, H Barthel, O Sabri, M Gutberlet
OBJECTIVE: To compare cardiac left ventricular (LV) parameters in simultaneously acquired hybrid fluorine-18-fluorodeoxyglucose ([18F] FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) in patients with residual tracer activity of upstream PET/CT. METHODS: Twenty-nine patients (23 men, age 58±17 years) underwent cardiac PET/MRI either directly after a non-cardiac PET/CT with homogenous cardiac [18F] FDG uptake (n=20) or for viability assessment (n=9)...
June 19, 2017: European Radiology
https://www.readbyqxmd.com/read/28629903/recording-adverse-events-following-joint-arthroplasty-financial-implications-and-validation-of-an-adverse-event-assessment-form
#8
Matthew J Lee, Khalid M S Mohamed, John C Kelly, John G Galbraith, John Street, Brian J Lenehan
BACKGROUND: In Ireland, funding of joint arthroplasty procedures has moved to a pay-by-results national tariff system. Typically, adverse clinical events are recorded via retrospective chart-abstraction methods by administrative staff. Missed or undocumented events not only affect the quality of patient care but also may unrealistically skew budgetary decisions that impact fiscal viability of the service. Accurate recording confers clinical benefits and financial transparency. The aim of this study was to compare a prospectively implemented adverse events form with the current national retrospective chart-abstraction method in terms of pay-by-results financial implications...
April 11, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28629357/xuefuzhuyu-decoction-protected-cardiomyocytes-against-hypoxia-reoxygenation-injury-by-inhibiting-autophagy
#9
Xiaowen Shi, Haiyan Zhu, Yuanyuan Zhang, Mingmei Zhou, Danli Tang, Huamin Zhang
BACKGROUND: XuefuZhuyu decoction (XFZY) is a well-known traditional Chinese herbal medicine for the treatment of various cardiovascular diseases, such as unstable angina pectoris and myocardial ischemia-reperfusion injury. However, the mechanism by which XFZY contributes to the amelioration of cardiac injury remains unclear. METHODS: H9C2 cells were cultured under the hypoxic condition for 10 h and reoxygenated for 2 h. In the presence of various concentrations of XFZY for 12 h, the cell viability was measured by MTT assay...
June 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28627660/inhibition-of-autophagy-by-berberine-enhances-the-survival-of-h9c2-myocytes-following-hypoxia
#10
Zhuyin Jia, Lu Lin, Shanjun Huang, Zhouyang Zhu, Weijian Huang, Zhouqing Huang
Hypoxia may induce apoptosis and autophagy to promote cardiomyocyte injury. The present study investigated the effect of berberine, a natural extract of Rhizoma Coptidis, on hypoxia‑induced autophagy and apoptosis in the H9c2 rat myocardial cell line. Expression levels of apoptosis and autophagy markers were upregulated in H9c2 myocytes during hypoxia and cell viability was reduced. However, berberine significantly reduced hypoxia‑induced autophagy in H9c2 myocytes, as demonstrated by the ratio of microtubule‑associated proteins 1A/1B light chain 3 I/II and the expression levels of B‑cell lymphoma 2 (Bcl‑2)/adenovirus E1B 19 kDa protein‑interacting protein 3, and promoted cell viability...
June 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28627657/shrna%C3%A2-mediated-np-knockdown-inhibits-the-apoptosis-of-cardiomyocytes-induced-by-h1n1pdm2009-influenza-virus
#11
Kun Yu, Yi Ren, Xiwen Zhang, Taiping Qiao, Zhiguo Liu, Jianhua Shi, Yingnan Wang
Acute influenza-associated myocarditis varies in clinical severity ranging between asymptomatic and fulminant varieties. The most severe cases can result in impaired cardiac function‑associated mortality; however, the mechanism underlying the development of viral myocarditis has yet to be fully elucidated. The present study investigated the apoptosis induced in H9C2 cardiomyocytes by infection with the H1N1pdm2009 virus. The H9C2 cells were transfected with nucleoprotein (NP)‑specific short hairpin (sh) RNA, and viral replication was re‑evaluated in H9C2 cells infected with the H1N1pdm2009 virus, as was the apoptosis induced by the virus...
June 8, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28626146/mitral-valve-structure-in-addition-to-myocardial-viability-determines-the-outcome-of-functional-mitral-regurgitation-after-coronary-artery-bypass-grafting
#12
Shohei Yoshida, Satsuki Fukushima, Shigeru Miyagawa, Teruya Nakamura, Yasushi Yoshikawa, Hiroki Hata, Shunsuke Saito, Daisuke Yoshioka, Keitaro Domae, Noriyuki Kashiyama, Kouji Yamamoto, Ayumi Shintani, Satoshi Nakatani, Koichi Toda, Yoshiki Sawa
BACKGROUND: Coronary artery bypass grafting (CABG) reduces functional mitral regurgitation (MR) associated with ischemic heart disease, although the predictive factors or mechanisms of reversibility of functional MR after CABG are not fully understood.We investigated whether mitral valve structure is associated with the outcome of functional MR after CABG.Methods and Results:From a consecutive series of 98 patients with mild-moderate functional MR preoperatively who underwent isolated CABG, we enrolled 66 patients who were followed up for >1 year postoperatively using echocardiography...
June 16, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28623695/injectable-cytocompatible-elastic-free-radical-scavenging-and-electroconductive-hydrogel-for-cardiac-cell-encapsulation
#13
Remya Komeri, Jayabalan Muthu
The injectable electroconductive hydrogels are desirable for the regenerative therapy of electroresponsive tissues like heart. With the present electroconductive hydrogels, the issues of cytotoxicity, biodegradability, and diffusion of the conductive element and poor water solubility limit their applications. Here, electroconductive injectable single component hydrogels, PANIE-P/PEGDA and PANIS-P/PEGDA, are prepared with fumarate-co-PEG-co-sebacate comacromer conjugated with non-sulfonated/sulfonated polyaniline and PEGDA...
June 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28620752/fatty-metaplasia-quantification-and-impact-on-regional-myocardial-function-as-assessed-by-advanced-cardiac-mr-imaging
#14
Tomas Lapinskas, Bernhard Schnackenburg, Marc Kouwenhoven, Rolf Gebker, Alexander Berger, Remigijus Zaliunas, Burkert Pieske, Sebastian Kelle
OBJECTIVE: This study aimed to investigate the advantages of recently developed cardiac imaging techniques of fat-water separation and feature tracking to characterize better individuals with chronic myocardial infarction (MI). MATERIALS AND METHODS: Twenty patients who had a previous MI underwent CMR imaging. The study protocol included routine cine and late gadolinium enhancement (LGE) technique. In addition, mDixon LGE imaging was performed in every patient. Left ventricular (LV) circumferential (EccLV) and radial (ErrLV) strain were calculated using dedicated software (CMR(42), Circle, Calgary, Canada)...
June 15, 2017: Magma
https://www.readbyqxmd.com/read/28619102/dl-3-n-butylphthalide-protects-the-heart-against-ischemic-injury-and-h9c2-cardiomyoblasts-against-oxidative-stress-involvement-of-mitochondrial-function-and-biogenesis
#15
Xiaochao Tian, Weiliang He, Rong Yang, Yingping Liu
BACKGROUND: Myocardial infarction (MI) is an acute and fatal condition that threatens human health. Dl-3-n-butylphthalide (NBP) has been used for the treatment of acute ischemic stroke. Mitochondria may play a protective role in MI injury. However, there are few reports on the cardioprotective effect of NBP or the potential mitochondrial mechanism for the NBP-induced protection against cardiac ischemia injury. We investigated the therapeutic effects of NBP in an in vivo MI model and an in vitro oxidative stress model, as well as the potential mitochondrial mechanism...
June 15, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28618929/anti-tumorigenic-effects-of-a-novel-digitoxin-derivative-on-both-estrogen-receptor-positive-and-triple-negative-breast-cancer-cells
#16
Yogesh M Kulkarni, Juan S Yakisich, Neelam Azad, Rajkumar Venkatadri, Vivek Kaushik, George O'Doherty, Anand Krishnan V Iyer
While there are targeted treatments for triple positive breast cancers, lack of specific biomarkers for triple-negative breast cancers (TNBC) has hindered the development of therapies for this subset of cancers. In this study, we evaluated the anticancer properties of cardiac glycoside Digitoxin (Dtx) and its synthetic analog MonoD on breast cancer cell lines MCF-7 (estrogen receptor-positive breast cancer) and MDA-MB-468 (triple-negative breast cancer). Both cardiac glycosides, at concentrations within the therapeutic range, increased the fraction of cells in the G0/G1 phase of the cell cycle, decreased viability, and inhibited the migration of MCF-7 and MDA-MB-468 cells...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28618416/shock-wave-therapy-promotes-cardiomyocyte-autophagy-and-survival-during-hypoxia
#17
Ling Du, Tao Shen, Bing Liu, Yunhe Zhang, Cong Zhao, Na Jia, Que Wang, Qing He
BACKGROUND: Autophagy plays an important role in cardiovascular disease. Controversy still exists regarding the effect of autophagy on ischemic/hypoxic myocardium. Cardiac shock wave therapy (CSWT) is an effective alternative treatment for refractory ischemic heart disease. Whether CSWT can regulate cardiomyocyte autophagy under hypoxic conditions is not clear. We established a myocardial hypoxia model using the H9c2 cell line and performed shock waves (SWs) treatment to evaluate the effect of SW on autophagy...
June 15, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28613164/model-based-generation-of-large-databases-of-cardiac-images-synthesis-of-pathological-cine-mr-sequences-from-real-healthy-cases
#18
Nicolas Duchateau, Maxime Sermesant, Herve Delingette, Nicholas Ayache
Collecting large databases of annotated medical images is crucial for the validation and testing of feature extraction, statistical analysis and machine learning algorithms. Recent advances in cardiac electromechanical modeling and image synthesis provided a framework to generate synthetic images based on realistic mesh simulations. Nonetheless, their potential to augment an existing database with large amounts of synthetic cases requires further investigation. We build upon these works and propose a revised scheme for synthesizing pathological cardiac sequences from real healthy sequences...
June 9, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28611075/identification-and-functional-characterization-of-hypoxia-induced-endoplasmic-reticulum-stress-regulating-lncrna-hyperlnc-in-pericytes
#19
Florian C Bischoff, Astrid Werner, David John, Jes-Niels Boeckel, Maria-Theodora Melissari, Phillip Grote, Simone F Glaser, Shemsi Demolli, Shizuka Uchida, Katharina M Michalik, Benjamin Meder, Hugo A Katus, Jan Haas, Wei Chen, Soni S Pullamsetti, Werner Seeger, Andreas M Zeiher, Stefanie Dimmeler, Christoph M Zehendner
Rationale: Pericytes are essential for vessel maturation and endothelial barrier function. Long non-coding RNAs (lncRNAs) regulate many cellular functions, but their role in pericyte biology remains unexplored. Objective: Here we investigate the effect of Hypoxia-Induced Endoplasmic Reticulum Stress Regulating lncRNA (HypERlnc, also known as ENSG00000262454) on pericyte function in vitro and its regulation in human heart failure and idiopathic pulmonary arterial hypertension. Methods and Results: RNA sequencing in human primary pericytes (hPCs) identified hypoxia regulated lncRNAs, including HypERlnc...
June 13, 2017: Circulation Research
https://www.readbyqxmd.com/read/28608184/assessment-of-left-ventricular-contraction-patterns-using-gated-spect-mpi-to-predict-cardiac-resynchronization-therapy-response
#20
Ningchao Tao, Yuanhao Qiu, Haipeng Tang, Zhiyong Qian, Hongping Wu, Rui Zhu, Yao Wang, Xiaofeng Hou, Weihua Zhou, Jiangang Zou
BACKGROUND: The U-shaped left ventricular (LV) contraction pattern, identified by MRI or echocardiography, is associated with improved CRT response. Gated SPECT MPI can measure both myocardial viability and mechanical dyssynchrony in a single scan. The aim of this study is to examine the relationship of the LV contraction pattern and the response of CRT in patients with left bundle branch block (LBBB). METHODS: Fifty-eight patients who met CRT guidelines and who had pre-CRT MPI were enrolled...
June 12, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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