keyword
MENU ▼
Read by QxMD icon Read
search

Biology

keyword
https://www.readbyqxmd.com/read/29169232/microcystic-stromal-tumor-of-testicle-first-case-report-and-literature-review
#1
Pengcheng Zhu, Yaqi Duan, Qilin Ao, Guoping Wang
Microcystic stromal tumor (MCST) is a rare subtype of sex cord-stromal neoplasm. Tumors from all 31 previously reported cases were located in the ovary. Herein, we present a unique case of a right-side testicular tumor in a 33-year-old Chinese male. The tumor is composed of predominantly lobulated cellular nodules separated by hyalinized fibrous stroma and they expressed CD10, β-catenin (nuclear) and cyclin D1. Molecular analysis identified a point mutation (c.110C>G) in exon 3 of CTNNB1. The histopathological features, immunohistochemistry profiles, and molecular analysis of this tumor were consistent with MCST of the ovary...
November 24, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29169230/ultrasonographic-features-of-pure-ductal-carcinoma-italic-in-situ-italic-of-the-breast-correlations-with-pathologic-features-and-biological-markers
#2
Hwajin Cha, Yun-Woo Chang, Eun Ji Lee, Ji Young Hwang, Hyun Joo Kim, Eun Hye Lee, Jung Kyu Ryu
Purpose: The purpose of this study was to evaluate the ultrasonographic features of pure ductal carcinoma in situ (DCIS) of the breast and to evaluate the correlations of ultrasonographic features with pathologic and biological features. Methods: A total of 141 lesions in 138 women with pure DCIS who underwent preoperative breast ultrasonography were retrospectively reviewed. Ultrasonographic features were analyzed using the American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) ultrasonography lexicon and the diagnostic criteria of the Japan Society of Ultrasonics in Medicine...
October 13, 2017: Ultrasonography
https://www.readbyqxmd.com/read/29169218/laccase-fermentation-of-clove-extract-increases-content-of-dehydrodieugenol-which-has-neuroprotective-activity-against-glutamate-toxicity-in-ht22-cells
#3
Han-Saem Lee, Eun-Ju Yang, Taeho Lee, Kyung-Sik Song
Enzyme fermentation is a type of food processing technique generally used to improve the biological activities of food and herbal medicines. In this study, the Syzygium aromaticum (clove) extract was fermented using laccase derived from Trametes versicolor (LTV). The fermented clove extract showed greater neuroprotective effects against glutamate toxicity on HT22 than the non-fermented extract did. HPLC analysis revealed that eugenol (1) and dehydrodieugenol (2) contents had decreased and increased, respectively, after fermentation...
November 25, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29169187/biologically-active-orbitides-from-the-euphorbiaceae-family
#4
Suelem D Ramalho, Meri Emili F Pinto, Douglas Ferreira, Vanderlan S Bolzani
A comprehensive overview of natural orbitides isolated from Euphorbiaceae species and their most relevant biological activities are presented. Euphorbiaceae is a large and diverse family, which comprises about 300 genera, and is known as an important source of medicines and toxins. Several classes of secondary metabolites have been described for this taxon, however, orbitides have been broadly reported in Jatropha and Croton genera. Additionally, the latex is documented as the main source of orbitides in this family...
November 23, 2017: Planta Medica
https://www.readbyqxmd.com/read/29169158/potential-targets-and-clinical-value-of-mir-224-5p-in-cancers-of-the-digestive-tract
#5
Lu Zhang, Lan-Shan Huang, Gang Chen, Zhen-Bo Feng
BACKGROUND/AIMS: MicroRNAs participate in various biological processes in malignant tumors. However, the mechanisms of miR-224-5p in digestive system cancers are not fully understood. A comprehensive investigation of the clinical value and potential targets of miR-224-5p in cancers of the digestive tract is necessary. METHODS: Expression profiling data and related-prognostic data of miR-224-5p were acquired from Gene Expression Omnibus, The Cancer Genome Atlas, ArrayExpress, and published literature...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169141/complicated-grief-and-caregiving-correlates-among-bereaved-adolescent-girls-in-south-africa
#6
Tonya R Thurman, Tory M Taylor, Brian Luckett, Alexandra Spyrelis, Johanna Nice
To our knowledge, this is the first study to document correlates of complicated grief among bereaved adolescents in sub-Saharan Africa. Participants included 339 female adolescents in South Africa who experienced the loss of a loved one at least six months prior to the survey; their primary caregivers were also surveyed. One-fifth of adolescents were classified as having complicated grief using the Inventory of Complicated Grief Revised for Children in conjunction with grief-induced functional impairment. The loss of a biological parent, the primary caregiver's level of grief, and economic stressors since the loss were associated with increased odds of complicated grief among adolescents...
November 20, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/29169139/analysis-of-extracellular-polymeric-substances-eps-and-ciprofloxacin-degrading-microbial-community-in-the-combined-fe-c-micro-electrolysis-ubaf-process-for-the-elimination-of-high-level-ciprofloxacin
#7
Longlong Zhang, Qinyan Yue, Kunlun Yang, Pin Zhao, Baoyu Gao
Extracellular polymeric substances (EPS) and ciprofloxacin-degrading microbial community in the combined Fe-C micro-electrolysis and up-flow biological aerated filter (UBAF) process for the treatment of high-level ciprofloxacin (CIP) were analyzed. The research demonstrated a great potential of Fe-C micro-electrolysis-UBAF for the elimination of high-level CIP. Above 90% of CIP removal was achieved through the combined process at 100 mg L(-1) of CIP loading. In UBAF, the pollutants were mainly removed at 0-70 cm heights...
November 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/29169111/identification-of-phenolic-components-via-lc-ms-analysis-and-biological-activities-of-two-centaurea-species-c-drabifolia-subsp-drabifolia-and-c-lycopifolia
#8
Gokhan Zengin, Dimitrina Zheleva-Dimitrova, Reneta Gevrenova, Paraskev Nedialkov, Andrei Mocan, Ana Ćirić, Jasmina Glamočlija, Marina Soković, Abdurrahman Aktumsek, M Fawzi Mahomoodally
The Centaurea genus has great potential in traditional systems and has attracted much interest in the design of novel drug formulations. The present study was focused on the chemical fingerprints and biological properties of Centaurea drabifolia subsp. drabifolia and Centaurea lycopifolia extracts. Spectrophotometric and LC-MS techniques were used to establish the chemical profiles of the studied extracts. Enzyme inhibitory potential was assessed against key enzymes linked to global health problems, namely neurodegenerative diseases (acetylcholinesterase), pigmentation (tyrosinase), and diabetes (α-amylase and α-glucosidase)...
November 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29169106/the-transcriptomic-changes-of-huipizhi-heidou-glycine-max-a-nematode-resistant-black-soybean-during-heterodera-glycines-race-3-infection
#9
Shuang Li, Yu Chen, Xiaofeng Zhu, Yuanyuan Wang, Ki-Hong Jung, Lijie Chen, Yuanhu Xuan, Yuxi Duan
Glycine max (soybean) is an extremely important crop, representing a major source of oil and protein for human beings. Heterodera glycines (soybean cyst nematode, SCN) infection severely reduces soybean production; therefore, protecting soybean from SCN has become an issue for breeders. Black soybean has exhibited a different grade of resistance to SCN. However, the underlying mechanism of Huipizhi Heidou resistance against SCN remains elusive. The Huipizhi Heidou (ZDD2315) and race 3 of Heterodera glycines were chosen to study the mechanism of resistance via examination of transcriptomic changes...
November 14, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29169091/effects-of-sulphur-on-the-performance-of-an-anaerobic-membrane-bioreactor-biological-stability-trace-organic-contaminant-removal-and-membrane-fouling
#10
Xiaoye Song, Wenhai Luo, James McDonald, Stuart J Khan, Faisal I Hai, Wenshan Guo, Hao H Ngo, Long D Nghiem
This study investigated the impact of sulphur content on the performance of an anaerobic membrane bioreactor (AnMBR) with an emphasis on the biological stability, contaminant removal, and membrane fouling. Removal of 38 trace organic contaminants (TrOCs) that are ubiquitously present in municipal wastewater by AnMBR was evaluated. Results show that basic biological performance of AnMBR regarding biomass growth and the removal of chemical oxygen demand (COD) was not affected by sulphur addition when the influent COD/SO4(2-) ratio was maintained higher than 10...
November 9, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29169089/effect-of-organic-loading-rate-on-anaerobic-co-digestion-of-rice-straw-and-pig-manure-with-or-without-biological-pretreatment
#11
Fei Shen, Hanguang Li, Xiaoyu Wu, Yuanxiu Wang, Qinghua Zhang
In this study, rice straw (RS) and pig manure (PM) mixtures with or without bio-pretreatment were used as the substrates and digested in a 9 L of anaerobic reactor at Organic loading rates (OLRs) of 0.4-3.1 kg COD/(m(3) d). The volumetric methane production rate (VMPR), methane yield and anaerobic stability were comparatively investigated. The results showed the co-anaerobic digestion processes of RS and PM mixture after biological pretreatment were very stable at OLRs of 0.4-2.5 kg COD/(m(3) d), and its optimal VMPR and methane yield could reach 0...
November 14, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29169080/novel-and-rare-prenyllipids-occurrence-and-biological-activity
#12
REVIEW
Renata Szymańska, Jerzy Kruk
The data presented indicate that there is a variety of unique prenyllipids, often of very limited taxonomic distribution, whose origin, biosynthesis, metabolism and biological function deserves to be elucidated. These compounds include tocoenols, tocochromanol esters, tocochromanol acids, plastoquinones and ubiquinones. Additionally, based on the available data, it can be assumed that there are still unrecognized prenyllipids, like prenylquinols fatty acid esters of the hydroquinone ring, including prenylquinol phosphates, and others, whose biological function might be of great importance...
November 14, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29169078/amino-acids-peptides-conjugated-heterocycles-a-tool-for-the-recent-development-of-novel-therapeutic-agents
#13
REVIEW
Meng Wang, K P Rakesh, Jing Leng, Wan-Yin Fang, L Ravindar, D Channe Gowda, Hua-Li Qin
Amino acids/peptide conjugated heterocycles represent an important class of therapeutical agents. Biologically active heterocycles are conjugated with amino acids or peptides to increase the drug resistance. Furthermore, the amino acid/peptide based drugs have low toxicity, ample bioavailability and permeability, modest potency and good metabolic and pharmacokinetic properties. Synthetic amino acid/peptides based heterocyclic conjugates constitute a promising choice for the development of new, less toxic and safer conventional pharmaceutical drugs in the near future...
November 16, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29169071/psychosocial-interventions-in-breast-cancer-survivorship-care
#14
REVIEW
Lisa M Gudenkauf, Shawna L Ehlers
Cancer distress screening and subsequent referral for psychosocial intervention has been mandated for continued cancer center accreditation. Increasing emphasis is being placed on the referral component of this mandate, ensuring that patient distress is not only identified but also effectively treated. Many evidence-based interventions exist for cancer distress. Specific interventions can effectively target biopsychosocial impacts of stress and promote adaptive coping, focusing on problem-solving, social support utilization, assertive communication, sexual health and intimacy, adherence to medical and supportive care recommendations, health behavior change, and emotional processing and expression...
November 20, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29169066/shining-a-light-on-enzyme-promiscuity
#15
REVIEW
Shelley D Copley
Most, if not all, enzymes are capable of catalyzing physiologically irrelevant secondary reactions-termed 'promiscuous' reactions-in addition to the reactions that they have evolved to catalyze. Promiscuous activities can provide the starting point for evolution of new enzymes, both in nature and in the hands of protein engineers. Recent work suggests that the universe of promiscuous activities available in nature is enormous. New high-throughput approaches have significantly advanced our ability to identify promiscuous activities, setting the stage for synthetic biology efforts to construct novel pathways using catalysts derived from promiscuous enzymes via directed evolution...
November 20, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/29169048/protein-lipoylation-an-evolutionarily-conserved-metabolic-regulator-of-health-and-disease
#16
REVIEW
Elizabeth A Rowland, Caroline K Snowden, Ileana M Cristea
Lipoylation is a rare, but highly conserved lysine posttranslational modification. To date, it is known to occur on only four multimeric metabolic enzymes in mammals, yet these proteins are staples in the core metabolic landscape. The dysregulation of these mitochondrial proteins is linked to a range of human metabolic disorders. Perhaps most striking is that lipoylation itself, the proteins that add or remove the modification, as well as the proteins it decorates are all evolutionarily conserved from bacteria to humans, highlighting the importance of this essential cofactor...
November 20, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29169039/heteromultivalent-targeting-of-integrin-%C3%AE-v%C3%AE-3-and-neuropilin-1-promotes-cell-survival-via-the-activation-of-the-igf-1-insulin-receptors
#17
Tao Jia, Jungyoon Choi, Jéremy Ciccione, Maxime Henry, Ahmad Mehdi, Jean Martinez, Béatrice Eymin, Gilles Subra, Jean-Luc Coll
Angiogenesis strongly depends on the activation of integrins, especially integrin αvβ3, and of neuropilin-1 (NRP-1), a co-receptor of VEGFR2. Dual-targeted molecules that simultaneously block both of them are expected have increased anti-angiogenic and antitumor activity. Toward this goal, we generated bifunctional 40 nm-sized silica nanoparticles (NPs) coated with controlled amounts of cRGD and ATWLPPR peptides and studied their affinity, selectivity and biological activity in HUVECs. Sub-nanomolar concentrations of NPs grafted either with ATWLPPR alone or in combination with cRGD exhibit potent and specific antagonist activity against VEGFR2/AKT signaling...
October 29, 2017: Biomaterials
https://www.readbyqxmd.com/read/29169026/structures-and-mechanisms-in-clay-nanopore-trapping-of-structurally-different-fluoroquinolone-antimicrobials
#18
Fanny E K Okaikue-Woodi, Sabrina E Kelch, Michael P Schmidt, Carmen Enid Martinez, Randall E Youngman, Ludmilla Aristilde
Smectite clay nanoparticles are implicated in the retention of antimicrobials within soils and sediments; these clays are also inspected as drug carriers in physiological systems. Cation exchange is considered the primary adsorption mechanism of antimicrobials within smectite nanopores. However, a dual role of acid-base chemistry and adsorptive structures is speculated by recent studies. Using the prototypical smectite clay montmorillonite, we employed a combination of X-ray diffraction (XRD), nuclear magnetic resonance, attenuated total reflectance-Fourier transform infrared spectroscopy, and molecular dynamics simulations to investigate the interlayer nanopore trapping of two structurally-different fluoroquinolone (FQ) antimicrobials with similar acid-base chemistry: ciprofloxacin (a first-generation FQ) and moxifloxacin (a third-generation FQ)...
November 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29169016/principles-of-systems-biology-no-23
#19
(no author information available yet)
This month: protein engineering (Mootha, Chica), synthetic biology (Khalil, You, Ting Lu, Timothy K. Lu), microbial ecology and evolution (Desai), side-stepping antibiotic resistance (Chandrasekaran), and mapping microbiomes (Borisy).
November 22, 2017: Cell Systems
https://www.readbyqxmd.com/read/29168976/biological-therapies-in-psoriasis-revisited
#20
Maria-Isabela Sârbu, Simona-Roxana Georgescu, Mircea Tampa, Alexandra-Elena Sârbu, Olga Simionescu
Psoriasis is a chronic, immune mediated disorder affecting approximately 2% of the population. Even in our days, patients with psoriasis are confronted with stigmatization and social rejection. As a result, their quality of life is significantly impaired. Biological therapies have revolutionized the treatment of moderate to severe psoriasis. The aim of this paper is to look over the most important biological therapies available for the management of plaque-type psoriasis.
November 27, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
keyword
keyword
1827
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"