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Hemolung

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https://www.readbyqxmd.com/read/27903208/early-experience-of-a-new-extracorporeal-carbon-dioxide-removal-device-for-acute-hypercapnic-respiratory-failure
#1
Ravindranath Tiruvoipati, Hergen Buscher, James Winearls, Jeff Breeding, Debasish Ghosh, Shimonti Chaterjee, Gary Braun, Eldho Paul, John F Fraser, John Botha
BACKGROUND: Recent advances in the technology of extracorporeal respiratory assist systems have led to a renewed interest in extracorporeal carbon dioxide removal (ECCOR). The Hemolung is a new, low-flow, venovenous, minimally invasive, partial ECCOR device that has recently been introduced to clinical practice to aid in avoiding invasive ventilation or to facilitate lung-protective ventilation. OBJECTIVE: We report our early experience on use, efficacy and safety of the Hemolung in three Australian intensive care units...
December 2016: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/27290276/ultra-low-tidal-volumes-and-extracorporeal-carbon-dioxide-removal-hemolung-%C3%A2-ras-in-ards-patients-a-clinical-feasibility-study
#2
F J Parrilla, L Bergesio, H Aguirre-Bermeo, J C Suarez, P López, I Morán, J Mancebo
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27266291/removal-of-extracorporeal-carbon-dioxide-in-chronic-obstructive-pulmonary-disease-patients
#3
Fulsen Bozkuş, Bora Bilal, Hafize Öksüz
The use of invasive mechanical ventilation (IMV) procedures in chronic obstructive pulmonary disease (COPD) patients suffering from episodes of acute exacerbation are associated with high rates of mortality. In this case study, we describe the use of a new device for extracorporeal carbon dioxide removal (ECCO2R) that can provide partial respiratory support for patients where noninvasive ventilation (NIV) proved insufficient. The case described in this manuscript represents the first clinical feasibility study for the Hemolung device, and was also the first use and application of the device at our department...
December 0: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/27195746/a-retrospective-observational-case-series-of-low-flow-venovenous-extracorporeal-carbon-dioxide-removal-use-in-patients-with-respiratory-failure
#4
Caroline E Moss, Eleanor J Galtrey, Luigi Camporota, Chris Meadows, Stuart Gillon, Nicholas Ioannou, Nicholas A Barrett
We aimed to describe the use of venovenous extracorporeal carbon dioxide removal (ECCO2R) in patients with hypercapnic respiratory failure. We performed a retrospective case note review of patients admitted to our tertiary regional intensive care unit and commenced on ECCO2R from August 2013 to February 2015. Fourteen patients received ECCO2R. Demographic data, physiologic data (including pH and partial pressure of carbon dioxide in arterial blood [PaCO2]) when starting ECCO2R (t = 0), at 4 hourly intervals for the first 24 hours, then at 24 hour intervals until cessation of ECCO2R, and overall outcome were recorded...
July 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/26674455/early-utilization-of-extracorporeal-co2-removal-for-treatment-of-acute-respiratory-distress-syndrome-due-to-smoke-inhalation-and-burns-in-sheep
#5
Stefan Kreyer, Vittorio Scaravilli, Katharina Linden, Slava M Belenkiy, Corina Necsoiu, Yansong Li, Christian Putensen, Kevin K Chung, Andriy I Batchinsky, Leopoldo C Cancio
INTRODUCTION: In thermally injured patients, inhalation injury is often associated with acute respiratory distress syndrome (ARDS), and is an independent predictor of increased morbidity and mortality. Extracorporeal CO2 removal (ECCO2R) therapy offers new possibilities in protective mechanical ventilation in ARDS patients. We performed an early application of ECCO2R in mild-to-moderate ARDS in sheep ventilated in BiPAP mode. Our aim was to investigate its effect on severity of the lung injury...
January 2016: Shock
https://www.readbyqxmd.com/read/26652524/prolonged-use-of-the-hemolung-respiratory-assist-system-as-a-bridge-to-redo-lung-transplantation
#6
Christian A Bermudez, Diana Zaldonis, Ming-Hui Fan, Joseph M Pilewski, Maria M Crespo
Although extracorporeal membrane oxygenation (ECMO) has been used frequently as a bridge to primary lung transplantation, active centers are conservative with this approach in patients requiring redo lung transplantation. We report the use of extracorporeal carbon dioxide removal, using the Hemolung respiratory assist system, as a prolonged bridge to lung transplantation, and the first use of the Hemolung as a bridge to redo lung transplantation. Hemolung support improved the patient's clinical status and allowed redo lung transplantation...
December 2015: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/26273934/enhanced-extracorporeal-co2-removal-by-regional-blood-acidification-effect-of-infusion-of-three-metabolizable-acids
#7
Vittorio Scaravilli, Stefan Kreyer, Katharina Linden, Slava Belenkiy, Antonio Pesenti, Alberto Zanella, Leopoldo C Cancio, Andriy I Batchinsky
Acidification of blood entering a membrane lung (ML) with lactic acid enhances CO2 removal (VCO2ML). We compared the effects of infusion of acetic, citric, and lactic acids on VCO2ML. Three sheep were connected to a custom-made circuit, consisting of a Hemolung device (Alung Technologies, Pittsburgh, PA), a hemofilter (NxStage, NxStage Medical, Lawrence, MA), and a peristaltic pump recirculating ultrafiltrate before the ML. Blood flow was set at 250 ml/min, gas flow (GF) at 10 L/min, and recirculating ultrafiltrate flow at 100 ml/min...
September 2015: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/26164598/intensive-hemodialysis-preserved-cardiac-injury
#8
Christopher T Chan, Guo Hua Li, Alan Valaperti, Peter Liu
Cardiac injury triggers cellular responses involving both cardiomyocytes and nonmuscle cells to process cardiac structural remodeling. End-stage renal disease (ESRD), despite conventional dialysis, is associated with adverse cardiac remodeling and increased cardiovascular events. Intensification of hemodialysis with nocturnal home hemodialysis (NHD; five sessions per week; 6-8 hours per treatment) was associated with regression of left ventricular hypertrophy and downregulation of genes in apoptosis and fibrosis...
September 2015: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/25588763/pre-clinical-evaluation-of-an-adult-extracorporeal-carbon-dioxide-removal-system-with-active-mixing-for-pediatric-respiratory-support
#9
R Garrett Jeffries, Yerbol Mussin, Denis S Bulanin, Laura W Lund, Ergin Kocyildirim, Zhaksybay Zh Zhumadilov, Farkhad S Olzhayev, William J Federspiel, Peter D Wearden
The objective of this work was to conduct pre-clinical feasibility studies to determine if a highly efficient, active-mixing, adult extracorporeal carbon dioxide removal (ECCO2R) system can safely be translated to the pediatric population. The Hemolung Respiratory Assist System (RAS) was tested in vitro and in vivo to evaluate its performance for pediatric veno-venous applications. The Hemolung RAS operates at blood flows of 350-550 ml/min and utilizes an integrated pump-gas exchange cartridge with a membrane surface area of 0...
December 2014: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/24614356/modular-extracorporeal-life-support-effects-of-ultrafiltrate-recirculation-on-the-performance-of-an-extracorporeal-carbon-dioxide-removal-device
#10
Vittorio Scaravilli, Stefan Kreyer, Katharina Linden, Slava Belenkiy, Bryan Jordan, Antonio Pesenti, Alberto Zanella, Kevin Chung, Jeremy Cannon, Leopoldo C Cancio, Andriy I Batchinsky
The combination of extracorporeal carbon dioxide removal (ECCO2R) and hemofiltration is a possible therapeutic strategy for patients needing both lung and renal support. We tested the effects of the recirculation of ultrafiltrate on membrane lung (ML) CO2 removal (VCO2ML). Three conscious, spontaneously breathing sheep were connected to a commercially produced ECCO2R device (Hemolung; Alung Technologies, Pittsburgh, PA) with a blood flow of 250 ml/min and a gas flow of 10 L/min. A hemofilter (NxStage, NxStage Medical, Lawrence, MA) was interposed in series after the ML...
May 2014: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/23499475/avoidance-of-intubation-during-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-for-a-lung-transplant-candidate-using-extracorporeal-carbon-dioxide-removal-with-the-hemolung
#11
Frank Bonin, Urte Sommerwerck, Laura W Lund, Helmut Teschler
No abstract text is available yet for this article.
May 2013: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/22926651/respiratory-dialysis-with-an-active-mixing-extracorporeal-carbon-dioxide-removal-system-in-a-chronic-sheep-study
#12
Peter D Wearden, William J Federspiel, Scott W Morley, Meir Rosenberg, Paul D Bieniek, Laura W Lund, Burt D Ochs
PURPOSE: The objective of this study was to demonstrate the safety and performance of a unique extracorporeal carbon dioxide removal system (Hemolung, ALung Technologies, Pittsburgh, PA) which incorporates active mixing to improve gas exchange efficiency, reduce exposure of blood to the circuit, and provide partial respiratory support at dialysis-like settings. METHODS: An animal study was conducted using eight domestic crossbred sheep, 6-18 months of age and 49-115 kg in weight...
October 2012: Intensive Care Medicine
https://www.readbyqxmd.com/read/21317644/respiratory-dialysis-reduction-in-dependence-on-mechanical-ventilation-by-venovenous-extracorporeal-co2-removal
#13
Andriy I Batchinsky, Bryan S Jordan, Dara Regn, Corina Necsoiu, William J Federspiel, Michael J Morris, Leopoldo C Cancio
OBJECTIVES: Mechanical ventilation is injurious to the lung. Use of lung-protective strategies may complicate patient management, motivating a search for better lung-replacement approaches. We investigated the ability of a novel extracorporeal venovenous CO2 removal device to reduce minute ventilation while maintaining normocarbia. DESIGN: Prospective animal study. SETTING: Government laboratory animal intensive care unit. SUBJECTS: Seven sedated swine...
June 2011: Critical Care Medicine
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