keyword
https://read.qxmd.com/read/38490331/new-onset-diabetes-after-kidney-transplantation-assessing-urinary-wilm-s-tumor-1-protein-to-predict-renal-allograft-dysfunction
#1
JOURNAL ARTICLE
César Endrigo Silva de Andrade, Karla Simone Costa de Souza, Ony Araújo Galdino, Mabelle Alves Ferreira de Lima, Paulo José de Medeiros, Marcela Abbott Galvão Ururahy, Maurício Galvão Pereira, José Bruno de Almeida, Adriana Augusto de Rezende
PURPOSE: New-onset diabetes after transplantation (NODAT) is a frequent metabolic complication associated with podocyte damage and renal allograft dysfunction. Thus, Wilm's tumor-1 (WT-1) protein, as a podocyte marker, holds promise as an option to evaluate renal allograft dysfunction in NODAT. Therefore, the study aimed to investigate urinary WT-1 levels in NODAT patients during the first year after kidney transplantation (KTx). MATERIALS AND METHODS: KTx patients were categorized into non-NODAT and NODAT groups...
March 13, 2024: Advances in Medical Sciences
https://read.qxmd.com/read/38484785/safety-and-efficacy-of-early-corticosteroid-withdrawal-in-liver-transplant-recipients-a-randomized-controlled-trial
#2
JOURNAL ARTICLE
Jongman Kim, Jae-Won Joh, Kwang-Woong Lee, Dong Lak Choi, Hee-Jung Wang
BACKGROUNDS/AIMS: Prolonged use of steroids after liver transplantation (LT) significantly increases the risk of diabetes or cardiovascular disease, which can adversely affect patient outcomes. Our study evaluated the effectiveness and safety of early steroid withdrawal within the first year following LT. METHODS: This study was conducted as an open-label, multicenter, randomized controlled trial. Liver transplant recipients were randomly assigned to one of the following two groups: Group 1, in which steroids were withdrawn two weeks posttransplantation, and Group 2, in which steroids were withdrawn three months posttransplantation...
March 15, 2024: Annals of Hepato-Biliary-Pancreatic Surgery
https://read.qxmd.com/read/38397919/glucometabolism-in-kidney-transplant-recipients-with-and-without-posttransplant-diabetes-focus-on-beta-cell-function
#3
JOURNAL ARTICLE
Amelie Kurnikowski, Benedetta Salvatori, Michael Krebs, Klemens Budde, Kathrin Eller, Julio Pascual, Micaela Morettini, Christian Göbl, Manfred Hecking, Andrea Tura
Posttransplant diabetes mellitus (PTDM) is a common complication after kidney transplantation. Pathophysiologically, whether beta-cell dysfunction rather than insulin resistance may be the predominant defect in PTDM has been a matter of debate. The aim of the present analysis was to compare glucometabolism in kidney transplant recipients with and without PTDM. To this aim, we included 191 patients from a randomized controlled trial who underwent oral glucose tolerance tests (OGTTs) 6 months after transplantation...
January 30, 2024: Biomedicines
https://read.qxmd.com/read/38345588/prevalence-and-risk-factors-of-new-onset-diabetes-after-transplant-in-east-africans
#4
JOURNAL ARTICLE
Salsabil Osman Nasir, Helen McCarthy, Ihab Abdel-Rahim Mohamed Ahmed
Very little is known about the prevalence of new-onset diabetes after transplant (NODAT) in sub-Saharan and Eastern Africans. Most of the data are related to African Americans and to North and South Africans. The aims of this study were to examine the prevalence of NODAT in Sudanese renal transplant recipients, compare it with the published literature, and identify the risk factors for developing NODAT. In total, 150 patients who received a living-related kidney transplant between January 2015 and January 2016 were included in this study...
July 1, 2023: Saudi Journal of Kidney Diseases and Transplantation
https://read.qxmd.com/read/38184212/neutrophil-lymphocyte-and-platelet-lymphocyte-ratios-measured-before-transplantation-and-their-correlation-with-new-onset-diabetes-post-transplantation-in-renal-transplant-recipients
#5
JOURNAL ARTICLE
Nguyen Thi Thuy Dung, Pham Vu Thuy, Nguyen Trí Tue, Truong Quy Kien, Nguyen Van Duc, Diem Thi Van, Do Manh Ha, Nguyen Thi Thu Ha, Phan Ba Nghia, Nguyen Trung Kien, Tran Van Hinh, Nguyen Minh Nui, Pham Quoc Toan, Nguyen Duc Loc, Dang Thi Viet Ha, Do Gia Tuyen, Le Viet Thang
PURPOSE: Our goal was to evaluate the neutrophil:lymphocyte (NLR) and platelet:lymphocyte (PLR) ratios measured before transplantation and their correlation with new-onset diabetes after transplantation (NODAT) in renal transplant recipients. PATIENTS AND METHODS: We conducted our study in 324 adult patients consecutively admitted to Military Hospital 103, Ha Noi, Viet Nam, who received kidney allografts from living donors. These patients were followed-up during the first 2 years post-transplantation for NODAT...
January 4, 2024: Transplant Immunology
https://read.qxmd.com/read/38171510/international-consensus-on-post-transplantation-diabetes-mellitus
#6
JOURNAL ARTICLE
Adnan Sharif, Harini Chakkera, Aiko P J de Vries, Kathrin Eller, Martina Guthoff, Maria C Haller, Mads Hornum, Espen Nordheim, Alexandra Kautzky-Willer, Michael Krebs, Aleksandra Kukla, Amelie Kurnikowski, Elisabeth Schwaiger, Nuria Montero, Julio Pascual, Trond G Jenssen, Esteban Porrini, Manfred Hecking
Post-transplantation diabetes mellitus (PTDM) remains a leading complication after solid organ transplantation. Previous international PTDM consensus meetings in 2003 and 2013 provided standardized frameworks to reduce heterogeneity in diagnosis, risk stratification and management. However, the last decade has seen significant advancements in our PTDM knowledge complemented by rapidly changing treatment algorithms for management of diabetes in the general population. In view of these developments, and to ensure reduced variation in clinical practice, a 3rd international PTDM Consensus Meeting was planned and held between 6-8 May 2022 in Vienna, Austria involving global delegates with PTDM expertise to update the previous report...
January 3, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38138933/adverse-drug-events-after-kidney-transplantation
#7
REVIEW
Lionel Rostaing, Thomas Jouve, Florian Terrec, Paolo Malvezzi, Johan Noble
Introduction: Kidney transplantation stands out as the optimal treatment for patients with end-stage kidney disease, provided they meet specific criteria for a secure outcome. With the exception of identical twin donor-recipient pairs, lifelong immunosuppression becomes imperative. Unfortunately, immunosuppressant drugs, particularly calcineurin inhibitors like tacrolimus, bring about adverse effects, including nephrotoxicity, diabetes mellitus, hypertension, infections, malignancy, leukopenia, anemia, thrombocytopenia, mouth ulcers, dyslipidemia, and wound complications...
December 14, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/38101939/evaluation-of-microvascular-complications-in-kidney-recipients-with-post-transplant-diabetes-mellitus
#8
JOURNAL ARTICLE
Başak Çelik Kavaklılar, Özge Aybı Özdemir, Tolga Yıldırım, Özlem Dikmetaş, Hilal Toprak, Vedat Hekimsoy, Alperen Onur İşler, Rahmi Yılmaz, Sibel Kadayıfçılar, Yunus Erdem, Tomris Erbas, Uğur Ünlütürk
CONTEXT: Limited data on microvascular complications in patients with post-transplant diabetes (PTDM) is an obstacle to developing follow-up algorithms. OBJECTIVES: To evaluate diabetic microvascular complications in patients with long-standing PTDM. METHODS: This study included patients with at least a five-year history of PTDM and age-matched renal transplant recipients without PTDM (NDM). Diabetic peripheral neuropathy (PN) was evaluated using the Michigan Neuropathy Screening Instrument (MNSI), the CASE IV device, and in vivo corneal confocal microscopy (CCM)...
December 15, 2023: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/37918578/genetic-variations-in-a-sestrin2-sestrin3-mtor-axis-and-development-of-new-onset-diabetes-after-kidney-transplantation
#9
JOURNAL ARTICLE
Don Vu, Tariq Shah, Prashant Sakharkar, David I Min
BACKGROUND: Genetic variations in Sestrin2/Sestrin3/ mTOR axis may cause obesity-associated metabolic syndrome, including lipid accumulation and insulin resistance thereby increasing individual's risk of diabetes. In this study, we explored the association between single nucleotide polymorphisms (SNPs) of these genes and new onset diabetes after transplantation in Hispanic renal transplant recipients (RTRs). METHODS: Nine potential functional polymorphisms in Sestrin2, Sestrin3 and mTOR genes were genotyped using the Taqman qPCR method in this study...
October 31, 2023: Transplant Immunology
https://read.qxmd.com/read/37858455/posttransplantation-diabetes-mellitus-after-liver-transplant-and-the-impact-of-family-history-of-diabetes-in-a-mexican-cohort
#10
JOURNAL ARTICLE
A Fernández-Ramírez, A Olivas-Martinez, J Ruiz-Manriquez, E Kauffman-Ortega, C Moctezuma-Velázquez, E Marquez-Guillen, A G Contreras, M Vilatobá, E González-Flores, R Cruz-Martínez, N C Flores-García, I García-Juárez
INTRODUCTION AND AIMS: Posttransplantation diabetes mellitus (PTDM) is a serious long-term complication that has a negative impact on graft and patient survival. The purpose of the present study was to describe the incidence of PTDM in a Mexican cohort and evaluate its association with a previous family history of diabetes (FHD). METHODS: A retrospective single-center cohort study was conducted on patients undergoing liver transplantation (LT). The primary outcome was time from LT to PTDM...
October 17, 2023: Revista de Gastroenterología de México
https://read.qxmd.com/read/37600749/influence-of-early-postoperative-basal-insulin-treatment-and-post-transplant-diabetes-mellitus-risk-on-health-related-quality-of-life-in-kidney-transplant-recipients-an-analysis-of-data-from-a-randomized-controlled-trial
#11
RANDOMIZED CONTROLLED TRIAL
Balazs Odler, Matthias Huemer, Elisabeth Schwaiger, Andrea Borenich, Amelie Kurnikowski, Marcell Krall, Hildegard Hafner-Giessauf, Georgios Eleftheriadis, Friderike Bachmann, Anna Faura, María José Pérez-Sáez, Julio Pascual, Klemens Budde, Alexander R Rosenkranz, Manfred Hecking, Kathrin Eller
Health-related quality of life (HRQOL) improves after kidney transplantation (KT) but declines over time. Studies on the effect of early postoperative basal insulin therapy on HRQOL after KT, especially KTRs at high risk of developing post-transplant diabetes mellitus (PTDM) are missing. Data from a randomized controlled trial on 148 non-diabetic KTRs were analyzed. HRQOL using the KDQOL-SF™ was compared in KTRs who either received early postoperative basal insulin therapy or standard-of-care and in KTRs at risk of developing PTDM...
2023: Transplant International
https://read.qxmd.com/read/37586963/diabetes-in-stiff-person-syndrome
#12
REVIEW
Petr Heneberg
Anti-glutamic acid decarboxylase (GAD) autoantibodies are a hallmark of stiff-person syndrome (SPS) and insulin-dependent diabetes mellitus (IDDM). However, patients with concurrent IDDM and SPS often manifest insulin resistance, and SPS-associated IDDM probably has heterogeneous causes. Some patients manifest IDDM associated only with high titers of anti-GAD65 caused by SPS. By contrast, other patients develop IDDM only after being treated with high-dose corticosteroids or they progress to insulin dependency following their treatment with high-dose corticosteroids...
October 2023: Trends in Endocrinology and Metabolism: TEM
https://read.qxmd.com/read/37410930/posttransplant-diabetes-mellitus-recent-developments-in-pharmacological-management-of-hyperglycemia
#13
REVIEW
Juan M Munoz Pena, Kenneth Cusi
CONTEXT: The management of solid-organ transplantation is rapidly evolving, and posttransplant diabetes mellitus (PTDM), which is increasingly common, is a barrier to transplant success, adversely impacting infection rates, allograft survival, cardiovascular disease, quality of life, and overall mortality. Currently, the management of PTDM relies primarily on intensified insulin therapy. However, emerging studies report that several noninsulin glucose-lowering agents are safe and effective in improving metabolic control and enhancing treatment adherence...
December 21, 2023: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/37289399/the-results-of-sglt-2-inhibitors-use-in-kidney-transplantation-1-year-experiences-from-two-centers
#14
JOURNAL ARTICLE
Mehmet Emin Demir, Tuba Elif Özler, Özgür Merhametsiz, Ulaş Sözener, Murathan Uyar, Zafer Ercan, Simge Bardak Demir, Siren Sezer, Gülçin Türkmen Sarıyıldız
PURPOSE: Sodium-glucose co-transporter-2 inhibitor (SGLT-2i) administration is associated with some concerns in regard to the increased risk of genital and urinary tract infections (UTI) in kidney transplant recipients (KTR). In this study, we present the results of SGLT-2i use in KTR, including the early post-transplant period. METHODS: Participants were divided into two groups: SGLT-2i-free diabetic KTR (Group 1, n = 21) and diabetic KTR using SGLT-2i (Group 2, n = 36)...
November 2023: International Urology and Nephrology
https://read.qxmd.com/read/37195045/endoplasmic-reticulum-stress-in-the-adipose-tissue-and-monocyte-chemoattractant-protein-1-are-involved-in-tacrolimus-induced-diabetes-mellitus
#15
JOURNAL ARTICLE
Xiaoxia Sun, Hongyang Wang, Jingwei Chi, Kui Che, Yangang Wang
Tacrolimus is an independent risk factor for new-onset diabetes after transplantation (NODAT). This study aimed to identify the mechanisms underlying tacrolimus-induced NODAT. About 80 kidney-transplant patients receiving tacrolimus were divided into NODAT and non-NODAT groups after 1 year. Binary logistic regression was used to identify risk factors for NODAT. Insulin resistance indices were estimated using the homeostasis model assessment. The blood levels of 13 adipocytokines were measured 1 week after transplantation...
June 2023: Pharmacology Research & Perspectives
https://read.qxmd.com/read/37151651/the-effect-of-pink1-parkin-pathway-on-glucose-homeostasis-imbalance-induced-by-tacrolimus-in-mouse-livers
#16
JOURNAL ARTICLE
Zhiwei Li, Jie Xiang, Shengmin Mei, Yue Wu, Yuan Xu
Treatment using the immunosuppressive drug tacrolimus (TAC) is related to new-onset diabetes after transplantation (NODAT). Previous studies focused mainly on islet β cells in the diabetogenic effect of TAC. Herein, we revealed that NODAT was probably induced by TAC via hepatic insulin resistance. After daily injection of mice with TAC, a glucose metabolism disorder was induced. In addition, TAC decreased the mRNA and protein levels of insulin receptor substrate 2 (IRS2), glucose transporter type 2 (GLUT2), and the phosphorylation of protein kinase B beta (pAKT2), which indicated impaired hepatic insulin signaling...
April 2023: Heliyon
https://read.qxmd.com/read/36525355/risk-factors-of-new-onset-diabetes-after-renal-transplantation-and-prognostic-analysis
#17
JOURNAL ARTICLE
Qi Wang, Jiangtao Wu, Xu Wang, Ying Huang, Guangping Li, Tongwen Ou
CONTEXT: New-onset diabetes after transplantation (NODAT) is one of the most common complications after renal transplantation and in kidney-transplant recipients is closely related to long-term adverse outcomes for recipients and transplants. The risk factors for NODAT still require exploration. OBJECTIVES: The study intended to explore the risk factors for new-onset diabetes after transplantation (NODAT) for patients receiving a renal transplantation, to provide a theoretical basis for reducing the incidence rate of NODAT and promoting a better outcome for patients...
December 16, 2022: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/36514718/the-association-of-pre-transplant-c-peptide-level-with-the-development-of-post-transplant-diabetes-a-cohort-study
#18
JOURNAL ARTICLE
Amanda J Vinson, Aran Thanamayooran, Bryce A Kiberd, Kenneth West, Ferhan S Siddiqi, Lakshman Gunaratnam, Karthik K Tennankore
BACKGROUND: Post-transplant diabetes mellitus (PTDM) is an important complication after kidney transplantation that results in reduced patient and allograft survival. Although there are established risk factors for PTDM, whether pretransplant C-peptide levels associate with PTDM is unknown. Therefore, in this study, we aimed to examine the association of pretransplant C-peptide levels with PTDM. METHODS: This was a cohort study of nondiabetic adult patients who underwent kidney transplant in Nova Scotia, Canada, between January 1, 2016, and March 31, 2021, with fasting C-peptide levels measured before transplant...
October 27, 2022: Kidney360
https://read.qxmd.com/read/36398015/effect-of-histone-deacetylase-inhibitor-vorinostat-on-new-onset-diabetes-induced-by-tacrolimus
#19
JOURNAL ARTICLE
Fatmah A Bakhdar, Hala S Abdel Kawy, Rania M Magadmi, Eman A El-Kordy, Abdulhakeem S Alamri
Objective: The immunosuppressant tacrolimus is a major cause of new-onset diabetes after transplantation. The aim of this study was to evaluate whether a low dose of the histone-deacetylase inhibitor (vorinostat) might ameliorate tacrolimus-induced new-onset diabetes. Methods: Thirty 8-week-old male Wistar rats were randomly divided into five groups: a control group, tacrolimus group (1.5 mg/kg intraperitoneally for 28 days), vorinostat group (15 mg/kg orally for 28 days), a group receiving tacrolimus with vorinostat for 28 days; and a group receiving coadministration of tacrolimus for 28 days and vorinostat for 14 days...
February 2023: Journal of Taibah University Medical Sciences
https://read.qxmd.com/read/36363565/prevalence-and-risk-factors-of-abnormal-glucose-metabolism-and-new-onset-diabetes-mellitus-after-kidney-transplantation-a-single-center-retrospective-observational-cohort-study
#20
JOURNAL ARTICLE
Carlo Alfieri, Evaldo Favi, Edoardo Campioli, Elisa Cicero, Paolo Molinari, Mariarosaria Campise, Maria Teresa Gandolfo, Anna Regalia, Donata Cresseri, Piergiorgio Messa, Giuseppe Castellano
Background and objectives: New-onset diabetes after transplantation (NODAT) represents a primary cause of morbidity and allograft loss. We assessed prevalence and risk factors for NODAT in a population of Italian kidney transplant (KT) recipients. Methods: Data from 522 KT performed between January 2004 and December 2014 were analyzed. Participants underwent clinical examination; blood and urine laboratory tests were obtained at baseline, one, six, and 12-month of follow-up to detect glucose homeostasis abnormalities and associated metabolic disorders...
November 7, 2022: Medicina
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