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Callum J Court, Jacqueline M Cole
Large auto-generated databases of magnetic materials properties have the potential for great utility in materials science research. This article presents an auto-generated database of 39,822 records containing chemical compounds and their associated Curie and Néel magnetic phase transition temperatures. The database was produced using natural language processing and semi-supervised quaternary relationship extraction, applied to a corpus of 68,078 chemistry and physics articles. Evaluation of the database shows an estimated overall precision of 73%...
June 19, 2018: Scientific Data
Jacob S Lu, Eckart Bindewald, Wojciech Kasprzak, Bruce A Shapiro
Summary: Creating clear, visually pleasing 2D depictions of RNA and DNA strands and their interactions is important to facilitate and communicate insights related to nucleic acid structure. Here we present RiboSketch, a secondary structure image production application that enables the visualization of multistranded structures via layout algorithms, comprehensive editing capabilities, and a multitude of simulation modes. These interactive features allow RiboSketch to create publication quality diagrams for structures with a wide range of composition, size, and complexity...
June 15, 2018: Bioinformatics
Myat Sanda Kyaw, Min Min Aye, Madison Grinnell, Morgan Rabach
Skin maladies affect populations worldwide and can have a vast range of clinical manifestations, signs, and complications, including infection, pain, or even stigma for sufferers due to their visibility. Both modern health infrastructure and indigenous systems offer solutions for patients. This contribution provides an overview of the dermatologic uses for Thanatka, a plant that is used topically in Myanmar to treat a myriad of skin diseases. Indigenous to Myanmar, the trees used to produce Thanatka are also present in India, Sri Lanka, Java, and Pakistan...
May 2018: Clinics in Dermatology
Rui P Guerra, Alexandra M Carvalho, Paulo Mateus
BACKGROUND AND OBJECTIVE: Pharmacokinetics comprises the study of drug absorption, distribution, metabolism and excretion over time. Clinical pharmacokinetics, focusing on therapeutic management, offers important insights towards personalised medicine through the study of efficacy and toxicity of drug therapies. This study is hampered by subject's high variability in drug blood concentration, when starting a therapy with the same drug dosage. Clustering of pharmacokinetics responses has been addressed recently as a way to stratify subjects and provide different drug doses for each stratum...
August 2018: Computer Methods and Programs in Biomedicine
Hendra Wibawa, Desniwaty Karo-Karo, Eko Sugeng Pribadi, Annemarie Bouma, Rogier Bodewes, Hans Vernooij, Diyantoro, Agus Sugama, David H Muljono, Guus Koch, Fadjar Sumping Tjatur Rasa, Arjan Stegeman
Highly pathogenic avian influenza virus (HPAIV) H5N1 has been reported in Asia, including Indonesia since 2003. Although several risk factors related to the HPAIV outbreaks in poultry in Indonesia have been identified, little is known of the contact structure of farms of different poultry production types (backyard chickens, broilers, layers, and ducks). This study aims to quantify the contact rates associated with the movement of people, and movements of live birds and products and equipment that affect the risk of HPAIV H5N1 transmission between poultry farms in Indonesia...
August 1, 2018: Preventive Veterinary Medicine
Raden Tina Dewi Judistiani, Lani Gumilang, Sefita Aryuti Nirmala, Setyorini Irianti, Deni Wirhana, Irman Permana, Liza Sofjan, Hesty Duhita, Lies Ani Tambunan, Jeffry Iman Gurnadi, Umar Seno, Reni Ghrahani, Agnes Rengga Indrati, Yunia Sribudiani, Tetty Yuniati, Budi Setiabudiawan
Studies had shown that iron-cycling was disturbed by inflammatory process through the role of hepcidin. Pregnancy is characterized by shifts of interleukin. Our objective was to determine if 25(OH) vitamin D (colecalciferol) status was associated with ferritin, anemia, and its changes during pregnancy. Method. A cohort study was done in 4 cities in West Java, Indonesia, beginning in July 2016. Subjects were followed up until third trimester. Examinations included were maternal ferritin, colecalciferol, and haemoglobin level...
2018: Anemia
Pratiwi Cahyaningrum, Sulistyawati Sulistyawati
OBJECTIVES: Malaria remains a public health concern worldwide, including Indonesia. Purworejo is a district in which endemic of malaria, they have re-setup to entering malaria elimination in 2021. Accordingly, actions must be taken to accelerate and guaranty that the goal will reach based on an understanding of the risk factors for malaria. Thus, we analysed malaria risk factors based on human and housing conditions in Kaligesing, Purworejo, Indonesia. METHODS: A case-control study was carried out in Kaligesing subdistrict, Purworejo, Indonesia in July to August 2017...
May 2018: Journal of Preventive Medicine and Public Health, Yebang Ŭihakhoe Chi
Jiajia Dong, Gael J Kergoat, Natállia Vicente, Cahyo Rahmadi, Shengquan Xu, Tony Robillard
Southeast Asia harbors an extraordinary species richness and endemism. While only covering 4% of the Earth's landmass, this region includes four of the planet's 34 biodiversity hotspots. Its complex geological history generated a megadiverse and highly endemic biota, attracting a lot of attention, especially in the field of island biogeography. Here we used the cricket genus Cardiodactylus as a model system to study biogeographic patterns in Southeast Asia. We carried out molecular analyses to: (1) infer phylogenetic relationships based on five mitochondrial and four nuclear markers, (2) estimate divergence times and infer biogeographical ancestral areas, (3) depict colonization routes, and summarize emigration and immigration events, as well as in situ diversification, and (4) determine whether shifts in species diversification occurred during the course of Cardiodactylus evolution...
June 7, 2018: Molecular Phylogenetics and Evolution
Xuan Cai, Changfeng Xiao, Huiqin Xue, Huihui Xiong, Yiqiong Hang, Jianxiong Xu, Yonghong Lu
The aim of this study was to compare the free radical scavenging ability and intestinal epithelial cell protective effects of Java tea ( Orthosiphon stamineus ) root extracts (ORE), stem extracts (OSE), and leaf extracts (OLE) to determine the potential of Java tea by-products. The Java tea extracts were prepared using a standard water-ethanol method. The antioxidant activity and intestinal protective effects were tested by H2 O2 -induced cell model and high-fat diet-induced mice model, respectively. The results showed that the total phenolic acid and flavonoid content and relative content were different in the ORE, OSE, and OLE...
May 2018: Food Science & Nutrition
Angela R Branche, Hongmei Yang, James Java, Jeanne Wiltse-Holden, David J Topham, Michael Peasley, Michael R Frost, Moon H Nahm, Ann R Falsey
INTRODUCTION: Pneumococcus is a commensal of the upper respiratory tract and colonization is common in young children. Carriage studies have provided insights on vaccine effects in children and may also be useful for assessing vaccines in adults. However, culture based prevalence studies in older adults describe low colonization rates. Therefore, we assessed cumulative incidence of pneumococcal colonization in older adults using polymerase chain reaction (PCR) targeting the lytA gene and risk factors for carriage...
June 2, 2018: Vaccine
Vitor Coelho, Michael Sammeth
Motivation: Alternative splicing (AS) has been demonstrated to play a role in shaping eukaryotic gene diversity at the transcriptional level. However, the impact of AS on the proteome is still controversial. Studies that seek to explore the effect of AS at the proteomic level are hampered by technical difficulties in the cumbersome process of casting forth and back between genome, transcriptome and proteome space coordinates, and the naïve prediction of protein domains in the presence of AS suffers many redundant sequence scans that emerge from constitutively spliced regions that are shared between alternative products of a gene...
June 1, 2018: Bioinformatics
Eric J Engstrom, Ivan Crozier
This article examines Emil Kraepelin's notion of comparative psychiatry and relates it to the clinical research he conducted at psychiatric hospitals in South-East Asia (1904) and the USA (1925). It argues that his research fits awkwardly within the common historiographic narratives of colonial psychiatry. It also disputes claims that his work can be interpreted meaningfully as the fons et origio of transcultural psychiatry. Instead, it argues that his comparative psychiatry was part of a larger neo-Lamarckian project of clinical epidemiology and was thus primarily a reflection of his own long-standing diagnostic practices and research agendas...
April 1, 2018: History of Psychiatry
Adrian L Breto, Kyle R Padgett, John C Ford, Deukwoo Kwon, Channing Chang, Martin Fuss, Radka Stoyanova, Eric A Mellon
Magnetic resonance-guided radiotherapy (MRgRT) is a new and evolving treatment modality that allows unprecedented visualization of the tumor and surrounding anatomy. MRgRT includes daily 3D magnetic resonance imaging (MRI) for setup and rapidly repeated near real-time MRI scans during treatment for target tracking. One of the more exciting potential benefits of MRgRT is the ability to analyze serial MRIs to monitor treatment response or predict outcomes. A typical radiation treatment (RT) over the span of 10-15 minutes on the MRIdian system (ViewRay, Cleveland, OH) yields thousands of "cine" images, each acquired in 250 ms...
March 28, 2018: Curēus
Yupadee Hengjan, Vidi Saputra, Didik Pramono, Chaerul Basri, Takeshi Ando, Yasushige Ohmori, Srihadi Agungpriyono, Eiichi Hondo
Flying foxes are important in the maintenance of forests and diversity. However, knowledge of their behavioral ecology, especially of movement and foraging patterns, which are essential for conservation and management of their populations, are not well known. Therefore, movement behavior of two individuals of Pteropus vampyrus were examined using an Argos telemetry system, and foraging pattern of Pteropus spp. was directly observed, at West Java province, Indonesia in October 2017. The maximum distance between the location at which bats were released and their furthest roost, recorded via satellite telemetry, was approximately 100 km...
May 30, 2018: Journal of Veterinary Medical Science
Sharon E Sonenblum, Jason Ma, Stephen H Sprigle, Thomas R Hetzel, John McKay Cathcart
AIM: To establish a research approach for describing how different wheelchair cushion designs impact buttocks tissue deformation during sitting. MATERIALS AND METHODS: The buttocks of 4 individuals with spinal cord injury and significant atrophy were scanned sitting in a FONAR Upright MRI. Scans were collected with the individuals' buttocks fully suspended without pelvic support, and seated on 3 different commercially available wheelchair cushions. Multi-planar scans were analyzed to provide 3D renderings and measurements of tissue thickness and shape...
May 9, 2018: Journal of Tissue Viability
Christiana R Titaley, Rita Damayanti, Nugroho Soeharno, Anifatun Mu'asyaroh, Mark Bradley, Tim Lynam, Alison Krentel
BACKGROUND: This research assesses knowledge amongst drug deliverers about the implementation of mass drug administration (MDA) for lymphatic filariasis (LF) in Agam District (West Sumatera Province), the City of Depok (West Java Province) and the City of Batam (Kepulauan Riau Province), Indonesia. METHODS: A cross-sectional survey was conducted from January to March 2015 at these three sites. Respondents were identified using purposive sampling (i.e. cadre, health worker or community representatives)...
May 25, 2018: Parasites & Vectors
Gurnoor Singh, Arnold Kuzniar, Erik M van Mulligen, Anand Gavai, Christian W Bachem, Richard G F Visser, Richard Finkers
BACKGROUND: A quantitative trait locus (QTL) is a genomic region that correlates with a phenotype. Most of the experimental information about QTL mapping studies is described in tables of scientific publications. Traditional text mining techniques aim to extract information from unstructured text rather than from tables. We present QTLTableMiner++ (QTM), a table mining tool that extracts and semantically annotates QTL information buried in (heterogeneous) tables of plant science literature...
May 25, 2018: BMC Bioinformatics
Adji P Setiadi, Yosi Wibowo, Eko Setiawan, Bobby Presley, Ika Mulyono, Ari S Wardhani, Bruce Sunderland
OBJECTIVE: To explore pharmacist/pharmacy staff trainers' perspectives on conducting community-based training to promote responsible self-medication, and to evaluate knowledge gained among community representatives participating in the training. METHODS: Training was conducted in four districts/cities in East Java, Indonesia in 2016. A pre-test/post-test study was used to evaluate the knowledge of 129 community representatives (participants) before/after the training; pre-test and post-test scores as well as absolute gain were determined...
May 24, 2018: International Journal of Pharmacy Practice
Sarah Nila, Julien Barthes, Pierre-Andre Crochet, Bambang Suryobroto, Michel Raymond
Male homosexual preference (MHP) challenges evolutionary thinking because the preference for male-male relationships is heritable, implies a fertility cost (lower offspring number), and is relatively frequent in some societies (2-6% in Western countries) for a costly trait. It has been proposed that individuals with a MHP counterbalance reproductive costs through the transfer of resources to kin, thereby improving their indirect reproduction through kin's reproductive success. This kin selection hypothesis is not supported in Western countries and Japan, although consistent evidence has been obtained in Samoa...
May 24, 2018: Archives of Sexual Behavior
Hadi Poorbagher, Hamed Ghaffari Farsani, Hamid Farahmand
DNA breakage has been frequently used as a biomarker of the pesticide toxicity. The present study introduced a method to quantify the DNA breakage in Oncorhynchus mykiss exposed to the pesticide Malathion. Specimens were exposed to different concentrations of malathion for 1-9 days and their gill and liver were sampled. DNA was extracted and electrophoresed using agarose gel. The pixel density curves were obtained from the gel smears. The area under the curves were arbitrarily divided from 3 up to 7 segments using a Java macro in the software ImageJ...
May 24, 2018: Toxicology Mechanisms and Methods
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