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https://www.readbyqxmd.com/read/29344743/response-to-different-furosemide-doses-predicts-aki-progression-in-icu-patients-with-elevated-plasma-ngal-levels
#1
Ryo Matsuura, Yohei Komaru, Yoshihisa Miyamoto, Teruhiko Yoshida, Kohei Yoshimoto, Rei Isshiki, Kengo Mayumi, Tetsushi Yamashita, Yoshifumi Hamasaki, Masaomi Nangaku, Eisei Noiri, Naoto Morimura, Kent Doi
BACKGROUND: Furosemide responsiveness (FR) is determined by urine output after furosemide administration and has recently been evaluated as a furosemide stress test (FST) for predicting severe acute kidney injury (AKI) progression. Although a standardized furosemide dose is required for FST, variable dosing is typically employed based on illness severity, including renal dysfunction in the clinical setting. This study aimed to evaluate whether FR with different furosemide doses can predict AKI progression...
January 17, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29334742/-diagnostic-and-prognostic-biomarkers-in-acute-coronary-syndrome
#2
Petr Kuběna, Jindřich Špinar, Milan Dastych, Petr Lokaj, Jiří Pařenica
Acute myocardial infarction (AMI) is an important cause of mortality and morbidity worldwide. Early diagnostics of this disease helps in the appropriate treatment of patients. Great attention is paid to the diagnostic and risk stratification of patients according to circulating biomarkers. There are a lot of scientific publications describing this topic. The aim of this article is to provide a comprehensive overview of the most important and most examined biomarkers in acute coronary syndrome. Meanwhile troponin takes a fundamental place for AMI diagnostic (mostly the high-sensitive methods) in preference to MB-fraction of creatine kinase and myoglobin...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29317152/predicting-long-term-outcomes-after-cardiac-arrest-by-using-serum-neutrophil-gelatinase-associated-lipocalin
#3
Yu-Ri Park, Joo Suk Oh, Hyunho Jeong, Jungtaek Park, Young Min Oh, Semin Choi, Kyoung Ho Choi
OBJECTIVES: Neutrophil gelatinase-associated lipocalin (NGAL) is secreted by various tissues in pathologic states. Previous studies reported that post-cardiac arrest serum NGAL levels correlate with short-term neurologic outcomes and survival. The aim of this study was to examine the associations between NGAL levels post-cardiac arrest and long-term outcomes and survival. METHODS: This prospective observational study and retrospective review included adult out-of-hospital cardiac arrest survivors who were treated by hypothermia-targeted temperature management...
December 7, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29304176/prediction-of-delayed-graft-function-and-long-term-graft-survival-by-serum-and-urinary-neutrophil-gelatinase-associated-lipocalin-during-the-early-postoperative-phase-after-kidney-transplantation
#4
Herbert Thomas Maier, Muhammad Imtiaz Ashraf, Christian Denecke, Sascha Weiss, Florian Augustin, Franka Messner, Natalie Vallant, Matthias Böcklein, Christian Margreiter, Georg Göbel, Johann Pratschke, Dietmar Öfner-Velano, Felix Aigner
Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as an early marker protein for kidney dysfunction in various clinical settings. In this prospective study we evaluated serial changes of serum and urinary NGAL within the first 7 days after kidney transplantation in 170 consecutive recipients. The main focus of this study was to assess the performance of serum and urinary NGAL in the prediction of delayed graft function (DGF) and two-year graft and patient survival. Serum and urine samples of 170 patients undergoing primary kidney transplantation from October 2010 to December 2012 were prospectively collected from day 0 to 7...
2018: PloS One
https://www.readbyqxmd.com/read/29303013/inhibition-of-plasma-kallikrein-kinin-system-to-alleviate-renal-injury-and-arthritis-symptoms-in-rats-with-adjuvant-induced-arthritis
#5
Jie Zhu, Hui Wang, Jingyu Chen, Wei Wei
BACKGROUND: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Impairment of kidney functions in RA was observed. However, the mechanism of kidney injury of RA has not been clear. Plasma kallikrein-kinin system (KKS) was involved in inflammatory processes in kidney disease. AIM: This study aimed to explore the role of plasma KKS in immune reactions and kidney injury of RA. RESULTS: The paw of AA rats appeared to be swelling and redness, the arthritis index was significantly increased on the 18, 21 and 24 d after injection and secondary inflammation in multi-sites was observed...
January 5, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29300232/early-postoperative-neutrophil-gelatinase-associated-lipocalin-predicts-the-development-of-chronic-kidney-disease-following-liver-transplantation
#6
Giuseppe Cullaro, Joseph F Pisa, Robert S Brown, Gebhard Wagener, Elizabeth C Verna
BACKGROUND: Urinary NGAL (uNGAL)-associated acute kidney injury (AKI) is common following liver transplant (LT), but whether early AKI predicts chronic kidney disease (CKD) and mortality remains uncertain. METHODS: Adults with LT from 2008-2010 in a previously published prospective cohort evaluating serial uNGAL pre- and post-LT were retrospectively assessed to evaluate uNGAL as a predictor of long-term outcomes post-LT. The primary outcomes were post-LT CKD, defined as MDRD estimated glomerular filtration rate (GFR)<60 mL/min/1...
January 3, 2018: Transplantation
https://www.readbyqxmd.com/read/29296216/calsyntenin-1-clusterin-and-neutrophil-gelatinase-associated-lipocalin-are-candidate-serological-biomarkers-for-lung-adenocarcinoma
#7
Yen Chu, Yu-Heng Lai, Ming-Cheng Lee, Yu-Jung Yeh, Yao-Kuang Wu, Wayne Tsao, Chun-Yao Huang, Semon Wu
It has been drawn attention that secreted proteins with signal peptide from cancer cells provide new potential biomarkers of cancer. In this study, three lung adenocarcinoma cell lines and serum samples from 20 patients were used for identifying potential serologic tumor biomarker with proteomic and bioinformatics approaches. One-dimensional electrophoresis, and identified with mass spectrometry and database research were performed. We found17 secreted proteins in common, while another 17 proteins with signal peptide were identified in all three lung adenocarcinoma cell lines alone with patient samples...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29289651/neutrophil-gelatinase-associated-lipocalin-from-immune-cells-is-mandatory-for-aldosterone-induced-cardiac-remodeling-and-inflammation
#8
Mathieu Buonafine, Ernesto Martínez-Martínez, Cristian Amador, Basile Gravez, Jaime Ibarrola, Amaya Fernández-Celis, Soumaya El Moghrabi, Patrick Rossignol, Natalia López-Andrés, Frédéric Jaisser
Immune system activation is involved in cardiovascular (CV) inflammation and fibrosis, following activation of the mineralocorticoid receptor (MR). We previously showed that Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a novel target of MR signaling in CV tissue and plays a critical role in aldosterone/MR-dependent hypertension and fibrosis. We hypothesized that the production of NGAL by immune cells may play an important part in the mediation of these deleterious mineralocorticoid-induced effects. We analyzed the effect of aldosterone on immune cell recruitment and NGAL expression in vivo...
December 28, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29288632/association-of-vascular-indices-with-novel-circulating-biomarkers-as-prognostic-factors-for-cardiovascular-complications-in-patients-with-type-2-diabetes-mellitus
#9
Katerina K Naka, Katerina Papathanassiou, Aris Bechlioulis, Konstantinos Pappas, Stelios Tigas, Dimitrios Makriyiannis, Sophia Antoniou, Nikolaos Kazakos, Alexandra Margeli, Ioannis Papassotiriou, Agathocles Tsatsoulis, Lampros K Michalis
BACKGROUND: The pathophysiology of atherosclerosis in type 2 diabetes mellitus (T2DM) is multifactorial. The association of vascular indices with circulating biomarkers of inflammation and insulin resistance and their role in the long-term cardiovascular prognosis in T2DM patients were currently investigated. PATIENTS AND METHODS: Patients with T2DM and poor glycemic control without known cardiovascular diseases (n=119) at baseline were enrolled and followed for about 9years...
December 27, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29285663/correlation-between-the-concentrations-of-lactoferrin-and-neutrophil-gelatinase-associated-lipocalin-in-meconium
#10
Barbara Lisowska-Myjak, Ewa Skarżyńska, Paulina Wilczyńska, Artur Jakimiuk
Neutrophil gelatinase-associated lipocalin (NGAL) and lactoferrin (Lf) are among the key components of the innate immune system due to their ability to bind iron with high affinity and thus control inflammation. The aim of this study was to test the use of NGAL and LF measurements in meconium for the assessment of the intrauterine homeostasis. NGAL and Lf concentrations were measured using ELISA kits in all serial meconium portions (n = 81) collected from 20 healthy neonates. Mean ± SD meconium concentration of Lf was 45...
December 29, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29279634/role-of-urinary-neutrophil-gelatinase-associated-lipocalin-as-a-biomarker-of-acute-kidney-injury-in-patients-with-circulatory-shock
#11
Radhey Shyam, Munna Lal Patel, Rekha Sachan, Satish Kumar, Durgesh Kumar Pushkar
Background: The early prediction of acute kidney injury (AKI) by the current clinical and laboratory methods remains inadequate. Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a promising noninvasive biomarker of kidney injury in shock. The aim of this study was to assess the ability of urinary NGAL (uNGAL) to predict AKI in adult Intensive Care Unit (ICU) patients. Materials and Methods: We prospectively studied 70 patients with circulatory shock admitted to the ICU over a period of 1 year...
November 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29276788/a-role-for-soluble-il-6-receptor-in-osteoarthritis
#12
Graham Akeson, Charles J Malemud
Interleukin-6 (IL-6) is one of several pro-inflammatory cytokines present at elevated levels in the synovial fluid of individuals with confirmed clinical diagnosis of rheumatoid arthritis (RA) and osteoarthritis (OA). The mechanism of action of IL-6 was shown to involve its capacity to interact with a membrane-bound IL-6 receptor (mIL-6Rα), also known as the "classical" IL-6 pathway, or through its interaction with a soluble IL-6 receptor (sIL-6R) termed the "trans-signaling" pathway. Activation of downstream signaling is transduced via these IL-6 receptors and principally involves the Janus Kinase/Signal Transduction and Activators of Transcription (JAK/STAT) signaling pathway that is further regulated by glycoprotein-130 (gp130) interacting with the IL-6/mIL-6R complex...
2017: Journal of Functional Morphology and Kinesiology
https://www.readbyqxmd.com/read/29258482/assessing-the-recovery-from-prerenal-and-renal-acute-kidney-injury-after-treatment-with-single-herbal-medicine-via-activity-of-the-biomarkers-hmgb1-ngal-and-kim-1-in-kidney-proximal-tubular-cells-treated-by-cisplatin-with-different-doses-and-exposure-times
#13
Sung-Man Oh, Gunhyuk Park, Seung Hoon Lee, Chang-Seob Seo, Hyeun-Kyoo Shin, Dal-Seok Oh
BACKGROUND: Acute kidney injury (AKI) is an initial factor in many kidney disorders. Pre- and intra-renal AKI biomarkers have recently been reported. Recovery from AKI by herbal medicine has rarely been reported. Thus, this study aimed to investigate the dose- and time-dependent effects of herbal medicines to protect against AKI in cisplatin-induced human kidney 2 (HK-2) cells by assessing the activities of high-mobility group box protein 1 (HMGB1), neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1)...
December 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29244860/lithium-reduces-blood-glucose-levels-but-aggravates-albuminuria-in-btbr-ob-ob-mice
#14
Theun de Groot, Lars Damen, Leanne Kosse, Mohammad Alsady, Rosalinda Doty, Ruben Baumgarten, Susan Sheehan, Johan van der Vlag, Ron Korstanje, Peter M T Deen
Glycogen synthase kinase 3 (GSK3) plays an important role in the development of diabetes mellitus and renal injury. GSK3 inhibition increases glucose uptake in insulin-insensitive muscle and adipose tissue, while it reduces albuminuria and glomerulosclerosis in acute kidney injury. The effect of chronic GSK3 inhibition in diabetic nephropathy is not known. We tested the effect of lithium, the only clinical GSK3 inhibitor, on the development of diabetes mellitus and kidney injury in a mouse model of diabetic nephropathy...
2017: PloS One
https://www.readbyqxmd.com/read/29231123/urinary-protein-biomarkers-of-kidney-injury-in-patients-receiving-cisplatin-chemotherapy
#15
Blessy George, Melanie S Joy, Lauren M Aleksunes
Despite recent progress in the development of novel approaches to treat cancer, traditional antineoplastic drugs, such as cisplatin, remain a mainstay of regimens targeting solid tumors. Use of cisplatin is limited by acute kidney injury, which occurs in approximately 30% of patients. Current clinical measures, such as serum creatinine and estimated glomerular filtration rate, are inadequate in their ability to detect acute kidney injury, particularly when there is only a moderate degree of injury. Thus, there is an urgent need for improved diagnostic biomarkers to predict nephrotoxicity...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29227537/ngal-gene-silencing-inhibits-proliferation-and-promotes-apoptosis-of-human-gastric-cancer-cells-an-in-vivo-and-in-vitro-study
#16
Ming-Yang Han, Jie-Wei Nie, Yuan-Yuan Li, Yuan-Zeng Zhu, Gang Wu
This study aims to explore effects of neutrophil gelatinase-associated lipocalin (NGAL) gene silencing on the proliferation and apoptosis of human gastric cancer MGC-803 and SGC-7901 cells. NGAL-siRNA was designed, synthesized and randomly divided into NGAL-siRNA and control-siRNA groups. Gastric cancer cells MGC-803 and SGC-7901 were grouped into blank, NGAL-OE, and control-OE groups. Expression of NGAL and apoptosis-related proteins were detected by qRT-PCR and Western blotting. Cell cycle and apoptosis were tested by flow cytometry, and cell proliferation by water soluble tetrazolium-1 (WST-1) assay...
December 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29217818/proteomic-analysis-of-perfusate-from-machine-cold-perfusion-of-transplant-kidneys-insights-into-protection-from-injury
#17
Michael A J Moser, Katherine Sawicka, Steven Arcand, Preston O'Brien, Patrick Luke, Gavin Beck, Jolanta Sawicka, Alejandro Cohen, Grzegorz Sawicki
BACKGROUND Machine cold perfusion is beneficial to the preservation of kidneys for transplantation. At the end of preservation, the perfusion solution contains many proteins. Using a proteomics approach, we searched for useful biomarkers and potential therapeutic targets in the perfusate. Our program is unique in that all transplant kidneys (even living donor kidneys, LKD) are placed on machine cold perfusion prior to transplantation. MATERIAL AND METHODS Perfusates from donation after neurological and circulatory determination of death (DNDD and DCDD respectively) and LKD were collected (n=41) and analyzed for LDH, neutrophil gelatinase-associated lipocalin (NGAL), and matrix metalloproteinase-2 (MMP-2) as markers of injury...
December 8, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29216946/-diagnostic-significance-of-urinary-neutrophil-gelatin-enzyme-related-lipid-delivery-protein-and-kidney-injury-molecule-1-in-acute-kidney-injury-after-cardiac-operation-with-cardiopulmonary-bypass-operation-in-children
#18
Yupeng Wen, Zongxiao Li, Cheng Chang, Peng Zhang, Yang Lyu
OBJECTIVE: To investigate the diagnostic value of urinary neutrophil gelatin enzyme-related lipid delivery protein (NGAL) and kidney injury molecule-1 (KIM-1) in the acute kidney injury (AKI) after cardiopulmonary bypass (CPB) operation in children with non-cyanotic congenital heart disease (CHD). METHODS: A retrospective analysis was conducted. 200 CPB undergoing cardiac surgery in children with non-cyanotic CHD admitted to Tianjin Children's Hospital from June 2015 to May 2017 were enrolled...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29211055/urinary-c-megalin-for-screening-of-renal-scarring-in-children-after-febrile-urinary-tract-infection
#19
Sohsaku Yamanouchi, Takahisa Kimata, Jiro Kino, Tetsuya Kitao, Chikushi Suruda, Shoji Tsuji, Hiroyuki Kurosawa, Yoshiaki Hirayama, Akihiko Saito, Kazunari Kaneko
BackgroundFebrile urinary tract infection (fUTI) in children may cause renal scarring. This study aimed to investigate the usefulness of urinary biomarkers for diagnosing renal scarring after fUTI.MethodsThirty-seven children (median age: 1.36 years, range: 0.52-12.17 years, 25 boys) with a history of fUTI, who underwent renal scintigraphy for 4 months or longer after the last episode of fUTI, were analyzed. A spot urine sample was obtained on the day of renal scintigraphy to measure levels of total protein, N-acetyl-β-D-glucosaminidase (NAG), β2-microglobulin (BMG), neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid binding protein (L-FABP), and C-megalin (full-length megalin)...
December 6, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29207099/n-acetylcysteine-ameliorates-contrast%C3%A2-induced-kidney-injury-in-rats-with-unilateral-hydronephrosis
#20
Qiang Xia, Chunxiao Liu, Xia Zheng
The aim of the present study was to investigate the protective effects of N‑acetylcysteine (NAC) on contrast‑induced acute kidney injury in rats with unilateral hyronephrosis. Eighty‑two male Sprague Dawley rats were randomized to undergo sham operation (n=14) or unilateral ureteral obstruction (UUO) (n=68). After 3 weeks, the UUO animals were randomized to three groups: NAC gastric perfusion, UUO+iohexol+NAC (n=24); normal saline perfusion, UUO+iohexol (n=24); and controls, UUO (n=20). After 3 days, UUO+iohexol+NAC and UUO+iohexol rats were injected with iohexol...
November 21, 2017: Molecular Medicine Reports
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