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https://www.readbyqxmd.com/read/27911858/the-antidepressant-fluoxetine-induces-necrosis-by-energy-depletion-and-mitochondrial-calcium-overload
#1
Emilie Charles, Mehdi Hammadi, Philippe Kischel, Vanessa Delcroix, Nicolas Demaurex, Cyril Castelbout, Anne-Marie Vacher, Anne Devin, Thomas Ducret, Paula Nunes, Pierre Vacher
Selective Serotonin Reuptake Inhibitor antidepressants, such as fluoxetine (Prozac), have been shown to induce cell death in cancer cells, paving the way for their potential use as cancer therapy. These compounds are able to increase cytosolic calcium concentration ([Ca2+]cyt), but the involved mechanisms and their physiological consequences are still not well understood. Here, we show that fluoxetine induces an increase in [Ca2+]cyt by emptying the endoplasmic reticulum (ER) through the translocon, an ER Ca2+ leakage structure...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27671782/the-development-of-in-vivo-measures-to-assess-the-impact-of-sex-drive-reducing-medications-in-an-offender-with-an-intellectual-disability
#2
Jerry A Rea, Michael R Dixon, Robert D Zettle, Kasey L Wright
The ability to adequately evaluate medications in the treatment of paraphilias has been limited by reliance upon self-report as a measure of effectiveness over periods of time that may be too short to detect reoffending. One solution to this shortcoming is the development of valid, long-term, stable assessment measures. The purpose of this case study was to analyze the effects of Prozac and Provera on an array of behaviors germane to the successful treatment of paraphilias, including: (a) sexual arousal in the laboratory and natural environment, (b) sexual thoughts (deviant and nondeviant) accompanied by arousal in the natural environment, and (c) overt actions in the community associated with increased risk of reoffending over a 31-month period for an exhibitionist with an intellectual disability...
September 26, 2016: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/27598965/anxiety-and-depression-with-neurogenesis-defects-in-exchange-protein-directly-activated-by-camp-2-deficient-mice-are-ameliorated-by-a-selective-serotonin-reuptake-inhibitor-prozac
#3
L Zhou, S L Ma, P K K Yeung, Y H Wong, K W K Tsim, K F So, L C W Lam, S K Chung
Intracellular cAMP and serotonin are important modulators of anxiety and depression. Fluoxetine, a selective serotonin reuptake inhibitor (SSRI) also known as Prozac, is widely used against depression, potentially by activating cAMP response element-binding protein (CREB) and increasing brain-derived neurotrophic factor (BDNF) through protein kinase A (PKA). However, the role of Epac1 and Epac2 (Rap guanine nucleotide exchange factors, RAPGEF3 and RAPGEF4, respectively) as potential downstream targets of SSRI/cAMP in mood regulations is not yet clear...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27513977/danio-rerio-embryos-on-prozac-effects-on-the-detoxification-mechanism-and-embryo-development
#4
V Cunha, P Rodrigues, M M Santos, P Moradas-Ferreira, M Ferreira
In the past decade the presence of psychopharmaceuticals, including fluoxetine (FLU), in the aquatic environment has been associated with the increasing trend in human consumption of these substances. Aquatic organisms are usually exposed to chronic low doses and, therefore, risk assessments should evaluate the effects of these compounds in non-target organisms. Teleost fish possess an array of active defence mechanisms to cope with the deleterious effects of xenobiotics. These include ABC transporters, phase I and II of cellular detoxification and oxidative stress enzymes...
September 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/27499056/treatment-with-the-selective-serotonin-reuptake-inhibitor-fluoxetine-attenuates-the-fish-hypoxia-response
#5
Jennifer M Panlilio, Sara Marin, Marissa B Lobl, M Danielle McDonald
The selective serotonin reuptake inhibitor (SSRI) fluoxetine (FLX), the active ingredient of the antidepressant drug Prozac, inhibits reuptake of the neurotransmitter, serotonin (5-HT; 5-hydroxytryptamine), into cells by the 5-HT transporter (SERT). Given the role of 5-HT in oxygen detection and the cardiovascular and ventilatory responses of fish to hypoxia, we hypothesized that treatment of the Gulf toadfish, Opsanus beta, with FLX would interfere with their response to hypoxia. Toadfish treated intra-arterially with 3...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27491349/synthesis-of-18-f-difluoromethylarenes-from-aryl-pseudo-halides
#6
Hang Shi, Augustin Braun, Lu Wang, Steven H Liang, Neil Vasdev, Tobias Ritter
A general method for the synthesis of [(18) F]difluoromethylarenes from [(18) F]fluoride for radiopharmaceutical discovery is reported. The method is practical, operationally simple, tolerates a wide scope of functional groups, and enables the labeling of a variety of arenes and heteroarenes with radiochemical yields (RCYs, not decay-corrected) from 10 to 60 %. The (18) F-fluorination precursors are readily prepared from aryl chlorides, bromides, iodides, and triflates. Seven (18) F-difluoromethylarene drug analogues and radiopharmaceuticals including Claritin, fluoxetine (Prozac), and [(18) F]DAA1106 were synthesized to show the potential of the method for applications in PET radiopharmaceutical design...
August 26, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27413150/serotonin-and-antidepressant-ssris-inhibit-rat-neuroendocrine-dopamine-neurons-parallel-actions-in-the-lactotrophic-axis
#7
David J Lyons, Rachida Ammari, Arash Hellysaz, Christian Broberger
UNLABELLED: Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed for depression, but sexual side effects often compromise compliance. These reproductive dysfunctions are likely mediated by elevations of the hormone prolactin. Yet, how serotonin (5-HT) and SSRIs cause changes in prolactin secretion is not known. Here, using in vitro whole-cell patch-clamp recordings, we show that 5-HT hyperpolarizes and abolishes phasic discharge in rat neuroendocrine tuberoinfundibular dopamine (TIDA) neurons, the main inhibitor of prolactin secretion...
July 13, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26961524/degradation-and-acute-toxicity-removal-of-the-antidepressant-fluoxetine-prozac-%C3%A2-in-aqueous-systems-by-electron-beam-irradiation
#8
Vanessa Honda Ogihara Silva, Ana Paula Dos Santos Batista, Antonio Carlos Silva Costa Teixeira, Sueli Ivone Borrely
Electron beam irradiation (EBI) has been considered an advanced technology for the treatment of water and wastewater, whereas very few previous investigations reported its use for removing pharmaceutical pollutants. In this study, the degradation of fluoxetine (FLX), an antidepressant marketed as Prozac(®), was investigated by using EBI at FLX initial concentration of 19.4 ± 0.2 mg L(-1). More than 90 % FLX degradation was achieved at 0.5 kGy, with FLX below the detection limit (0.012 mg L(-1)) at doses higher than 2...
June 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/26806870/acute-fluoxetine-exposure-alters-crab-anxiety-like-behaviour-but-not-aggressiveness
#9
Trevor James Hamilton, Garfield T Kwan, Joshua Gallup, Martin Tresguerres
Aggression and responsiveness to noxious stimuli are adaptable traits that are ubiquitous throughout the animal kingdom. Like vertebrate animals, some invertebrates have been shown to exhibit anxiety-like behaviour and altered levels of aggression that are modulated by the neurotransmitter serotonin. To investigate whether this influence of serotonin is conserved in crabs and whether these behaviours are sensitive to human antidepressant drugs; the striped shore crab, Pachygrapsus crassipes, was studied using anxiety (light/dark test) and aggression (mirror test) paradigms...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26766390/long-term-exposure-to-fluoxetine-reduces-growth-and-reproductive-potential-in-the-dominant-rocky-intertidal-mussel-mytilus-californianus
#10
Joseph R Peters, Elise F Granek
Environmental stressors shape community composition and ecosystem functioning. Contaminants such as pharmaceuticals are of increasing concern as an environmental stressor due to their persistence in surface waters worldwide. Limited attention has been paid to the effects of pharmaceuticals on marine life, despite widespread detection of these contaminants in the marine environment. Of the existing studies, the majority assess the negative effects of pharmaceuticals over an exposure period of 30 days or less and focus on cellular and subcellular biomarkers...
March 1, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/26547508/a-patchwork-paper-what-paediatricians-should-read
#11
Andrew Bush
This paper honours a paediatrician whose career has been patchwork but distinguished, with many facets. It is a light-hearted look at the printed (infinitely preferable to the electronic) word. Although the obvious response is "read everything I have written", this would only drive down the stores of Prozac. Read the scientific literature of course. The oldie reads to stay one jump ahead on the ward round. Meta-analyses and systematic reviews rely on the judgement of others, so should be regarded with suspicion...
January 2016: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/26462219/the-silence-of-prozac
#12
Katherine Sharpe
No abstract text is available yet for this article.
October 2015: Lancet Psychiatry
https://www.readbyqxmd.com/read/26453812/prozac-affects-stickleback-nest-quality-without-altering-androgen-spiggin-or-aggression-levels-during-a-21-day-breeding-test
#13
Marion Sebire, Jessica Elphinstone Davis, Robert Hatfield, Svante Winberg, Ioanna Katsiadaki
Pharmaceuticals are increasingly being used in human and veterinary medicine, and their presence in the aquatic environment may present a threat to non-target aquatic organisms. The selective serotonin reuptake inhibitor fluoxetine (Prozac) has been reported to affect diverse behaviours (feeding, aggression, and reproduction) and also the endocrine system (steroid biosynthesis pathway) in fish. To investigate these claims further, and in particular effects on androgen synthesis, male three-spined sticklebacks (Gasterosteus aculeatus) were exposed to fluoxetine at 0, 3...
November 2015: Aquatic Toxicology
https://www.readbyqxmd.com/read/26303305/behavioral-endocrine-and-neuronal-alterations-in-zebrafish-danio-rerio-following-sub-chronic-coadministration-of-fluoxetine-and-ketamine
#14
Julian Pittman, Andrew Hylton
Most existing pharmacological treatments have focused on the "monoamine hypothesis" for targeted drug design for major depressive disorder (MDD). Many of these medications have a delayed onset-of-action and limited efficacy. Antidepressants with principal targets outside the monoamine system may offer the potential for more rapid activity with improved therapeutic benefit. Growing evidence suggests that the glutamatergic system is uniquely central to the neurobiology and treatment of MDD. Ketamine (Ketalar®) is a non-competitive glutamatergic antagonist classically used to induce sedation...
December 2015: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/26242607/adolescent-daughters-and-ritual-abjection-narrative-analysis-of-self-injury-in-four-us-films
#15
Warren Bareiss
Media representations of illnesses, particularly those associated with stigma such as non-suicidal self-injury (NSSI), not only define health conditions for mass audiences, but generally do so in ways that are consistent with dominant ideologies. This article examines the construction of non-suicidal self-injury as practiced by female adolescents and young adults in four US films: Girl, Interrupted, Painful Secrets, Prozac Nation, and Thirteen. The methodology used to examine the films' narrative structure is Kenneth Burke's dramatism, while Julia Kristeva's concept of abjection informs the analysis...
August 6, 2015: Journal of Medical Humanities
https://www.readbyqxmd.com/read/26232582/new-insights-into-the-acute-actions-from-a-high-dosage-of-fluoxetine-on-neuronal-and-cardiac-function-drosophila-crayfish-and-rodent-models
#16
Zana R Majeed, Kyle Ritter, Jonathan Robinson, Sandra L E Blümich, Eugen Brailoiu, Robin L Cooper
The commonly used mood altering drug fluoxetine (Prozac) in humans has a low occurrence in reports of harmful effects from overdose; however, individuals with altered metabolism of the drug and accidental overdose have led to critical conditions and even death. We addressed direct actions of high concentrations on synaptic transmission at neuromuscular junctions (NMJs), neural properties, and cardiac function unrelated to fluoxetine's action as a selective 5-HT reuptake inhibitor. There appears to be action in blocking action potentials in crayfish axons, enhanced occurrences of spontaneous synaptic vesicle fusion events in the presynaptic terminals at NMJs of both Drosophila and crayfish...
October 2015: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/26126230/chronic-exposure-to-environmentally-relevant-concentrations-of-fluoxetine-prozac-decreases-survival-increases-abnormal-behaviors-and-delays-predator-escape-responses-in-guppies
#17
Marco Pelli, Victoria P Connaughton
This study evaluates the impact of fluoxetine, an antidepressant drug and common pollutant in aquatic environments, on growth, survival, and behavior in juvenile guppies and on predator escape responses in adult guppies (Poecilia reticulata). In juveniles, the effects of acute (4d) and chronic (35d) exposure on growth and survival were examined, and behavioral changes were noted throughout the chronic experiment. In adults, escape responses to a mock predator during chronic (28d) fluoxetine exposure were videotaped to determine the overall speed of response in treated vs...
November 2015: Chemosphere
https://www.readbyqxmd.com/read/25854014/-efficacy-on-post-stroke-depression-treated-with-acupuncture-at-the-acupoints-based-on-ziwuliuzhu-and-prozac
#18
RANDOMIZED CONTROLLED TRIAL
Yunting Sun, Yehua Bao, Shuling Wang, Jiamei Chu, Liping Li
OBJECTIVE: To observe the effects on post-stroke depression treated with acupuncture at the acu points based on ziwuliuzhu (the midnight-noon ebb-flow theory). METHODS: Ninety-three patients were randomized into a comprehensive group, a ziwuliuzhu group and a prozac group, 31 cases in each group. In the ziwuliuzhu group, acupuncture was applied to the acupoints based on ziwuliuzhu, once a day, 5 times in a week. In the prozac group, fluoxertine hydrochloride (prozac) was prescribed for oral administration, once a day, 20 mg each time...
February 2015: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/25766236/k2p-channel-gating-mechanisms-revealed-by-structures-of-trek-2-and-a-complex-with-prozac
#19
Yin Yao Dong, Ashley C W Pike, Alexandra Mackenzie, Conor McClenaghan, Prafulla Aryal, Liang Dong, Andrew Quigley, Mariana Grieben, Solenne Goubin, Shubhashish Mukhopadhyay, Gian Filippo Ruda, Michael V Clausen, Lishuang Cao, Paul E Brennan, Nicola A Burgess-Brown, Mark S P Sansom, Stephen J Tucker, Elisabeth P Carpenter
TREK-2 (KCNK10/K2P10), a two-pore domain potassium (K2P) channel, is gated by multiple stimuli such as stretch, fatty acids, and pH and by several drugs. However, the mechanisms that control channel gating are unclear. Here we present crystal structures of the human TREK-2 channel (up to 3.4 angstrom resolution) in two conformations and in complex with norfluoxetine, the active metabolite of fluoxetine (Prozac) and a state-dependent blocker of TREK channels. Norfluoxetine binds within intramembrane fenestrations found in only one of these two conformations...
March 13, 2015: Science
https://www.readbyqxmd.com/read/25527800/-prozac-baby-25-years-of-motherisk-research-into-ssris-and-alcohol-in-pregnancy
#20
Gideon Koren
A summary of the debate regarding the safety of antidepressants in pregnancy is presented through the story of Prozac Baby. This is a diary of a fetus who finds out (to his horror) that his mother intends to abort him due to misinformation she has received. The novel, Prozac Baby, was written by Dr. Gideon Koren, based on his experience at Motherisk. An update on the risks of alcohol in pregnancy is also provided.
2014: Journal of Population Therapeutics and Clinical Pharmacology
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