keyword
https://read.qxmd.com/read/38536418/imatinib-pharmacokinetics-and-creatine-kinase-levels-in-chronic-myeloid-leukemia-patients-implications-for-therapeutic-response-and-monitoring
#1
JOURNAL ARTICLE
Mervat M Omran, Amel B Ibrahim, Raafat Abdelfattah, Samia A Shouman, Marwa S Hamza
BACKGROUND: Imatinib treatment for certain cancers can lead to elevated creatine kinase (CK) levels, potentially indicating muscle injury, and ongoing research aims to understand the correlation between imatinib levels and creatine kinase to assess its impact on treatment response. METHODS: This single-center observational study involved 76 chronic myeloid leukemia (CML) patients receiving imatinib treatment, focusing on evaluating drug and metabolite levels using liquid chromatography-mass spectrometry (LC-MS-MS) instrumentation...
March 27, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38530222/enzymes-as-indispensable-markers-in-disease-diagnosis
#2
REVIEW
Shehabaz Usman Pathan, Akash Kharwar, Madaje Amir Ibrahim, Shashi Bala Singh, Priyanka Bajaj
Enzymes have been used for disease diagnosis for many decades; however, advancements in technology like ELISA and flow cytometry-based detection have significantly increased their use and have increased the sensitivity of detection. Technological advancements in recombinant enzyme production have increased enzymatic stability, and the use of colorimetric-based and florescence-based assays has led to their increased use as biomarkers for disease detection. Enzymes like acid phosphatase, cathepsin, lactate dehydrogenase, thymidine kinase and creatine kinase are indispensable markers for diagnosing cancer, cardiovascular diseases and others...
March 26, 2024: Bioanalysis
https://read.qxmd.com/read/38529720/upregulation-and-epigenetic-modification-of-the-creatine-transporter-slc6a8-in-non-small-cell-lung-cancer
#3
JOURNAL ARTICLE
Christiane Kuempers, Karoline Schnepf, Sebastian Marwitz, Christian Watermann, Andreas Scheel, Rieke N Fischer, Ole Ammerpohl, Sven Perner, Daniel Drömann, Torsten Goldmann
INTRODUCTION: Lung cancer is a major cause of cancer-related death worldwide and effective therapies, besides surgery, are available only for a small proportion of patients. Since cellular respiration is known to be broadly altered in malignant tumors, the cellular processes of respiration can be a potential therapeutic target. One important element of cellular respiration is creatine and its transport by the creatine transporter SLC6A8. Here we describe the expression of SLC6A8 at the RNA and protein level, epigenetic modifications as well as survival analysis in NSCLC tissues and matched controls...
March 7, 2024: Histology and Histopathology
https://read.qxmd.com/read/38524002/mutation-of-pten-loss-and-likelihood-of-being-a-non-responder-to-trastuzumab-in-a-sample-of-iraqi-her2-breast-cancer-patients
#4
JOURNAL ARTICLE
Alyaa H Hammadi, Shatha H Ali
INTRODUCTION: PTEN controls upstream PI3K relatives, such as AKT. PTEN gene mutations have been documented to affect outcomes in main or distant malignancies, including breast cancer (BC). PTEN gene deletions are common in a variety of human cancers. A key factor in the response to this kind of therapy is genetic diversity. The purpose of this research is to determine whether a PTEN loss mutation influences a patient's propensity to not respond to trastuzumab (TRS) in cases of Her2+ BC...
February 2024: Curēus
https://read.qxmd.com/read/38519729/correction-ubiquitous-mitochondrial-creatine-kinase-promotes-the-progression-of-gastric-cancer-through-a-jnk-mapk-jun-hk2-axis-regulated-glycolysis
#5
Yushuai Mi, Quanhui Li, Bingtian Liu, Dehai Wang, Ziping Liu, Tianshi Wang, Yuan Wang, Yifeng Zang, Yan Zhou, Yugang Wen, Yinlu Ding
No abstract text is available yet for this article.
March 22, 2024: Gastric Cancer
https://read.qxmd.com/read/38516099/sintilimab-plus-anlotinib-as-second-or-further-line-therapy-for-extensive-disease-small-cell-lung-cancer-a-phase-2-investigator-initiated-non-randomized-controlled-trial
#6
JOURNAL ARTICLE
Shuxiang Ma, Zhen He, Yang Liu, Lili Wang, Sen Yang, Yufeng Wu, Haiyang Chen, Yingxi Wu, Qiming Wang
BACKGROUND: Treatment options remain rather limited for extensive disease small cell lung cancer (ED-SCLC) patients in second or further-line setting. METHODS: The phase 2 investigator-initiated non-randomized study enrolled patients who had disease progression on at least one line of platinum-based chemotherapy. Participants received intravenous sintilimab 200 mg on day one and oral daily anlotinib 12 mg on days 1-14 once every three weeks per cycle. The primary endpoint was progression-free survival (PFS)...
April 2024: EClinicalMedicine
https://read.qxmd.com/read/38491548/fulminant-myocarditis-during-postoperative-adjuvant-chemotherapy-for-lung-cancer-with-atezolizumab-a-case-report
#7
JOURNAL ARTICLE
Takuya Tokunaga, Masaya Aoki, Koki Maruyama, Yuto Nonaka, Kota Kariatsumari, Koichi Sakasegawa, Kazuhiro Ueda
BACKGROUND: Postoperative adjuvant systemic therapy with atezolizumab for lung cancer has been reported to be effective. Although myocarditis is a rare immune adverse event associated with atezolizumab, it can have a serious course and should be treated with caution. We herein report a case of fulminant myocarditis during adjuvant systemic therapy with atezolizumab. CASE PRESENTATION: The patient was a 49-year-old Asian woman. She was diagnosed with pT2aN1M0 stage IIB (Programmed Death Ligand 1(PD-L1), 50%) after surgery for right upper lobe lung adenocarcinoma...
March 16, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38457543/coxsackie-b-virus-induced-myocarditis-in-a-patient-with-a-history-of-lymphoma-a-case-report-and-review-of-literature
#8
JOURNAL ARTICLE
Qian Zhang, Jia Yuan, Wei Zhao, Weiwei Ouyang, Bowen Chen, Yehong Li, Junling Tao, Xianjun Chen, Guangsu Li, Zhendong Guo, Ying Liu
INTRODUCTION: In rare occasions, coxsackievirus infections can cause serious illness, such as encephalitis and myocarditis. The immunotherapies of cancer could increase the risk of myocarditis, especially when applying immune checkpoint inhibitors. Herein, we report a rare case of Coxsackie B virus-induced myocarditis in a patient with a history of lymphoma. CASE PRESENTATION: A 32-year-old woman was admitted to the hospital with recurrent fever for more than 20 days, and she had a history of lymphoma...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38430166/systematic-assessment-of-chinese-medicine-compounds-for-mitigating-anthracycline-induced-cardiotoxicity
#9
JOURNAL ARTICLE
Jing Yang, Feng Wang, Zhirong Wang, Lixin Wang
BACKGROUND: Anthracycline chemotherapy is highly effective in treating various cancers but is associated with significant cardiotoxicity. Chinese herbal compounds have shown promise in mitigating this adverse effect, warranting systematic evaluation for clinical applicability. OBJECTIVE: This study seeks to systematically assess the effectiveness of Chinese herbal compounds in managing anthracycline-induced cardiotoxicity via meta-analysis. The objective is to establish an evidence-based framework for their clinical use in preventing and treating this condition...
March 1, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38423241/ursolic-acid-alleviates-cancer-cachexia-by-inhibiting-stat3-signaling-pathways-in-c2c12-myotube-and-ct26-tumor-bearing-mouse-model
#10
JOURNAL ARTICLE
Li Chen, Yan Chen, Mengxia Wang, Linglin Lai, Linbo Zheng, Huiqin Lu
Cancer cachexia, a multi-organ disorder resulting from tumor and immune system interactions, prominently features muscle wasting and affects the survival of patients with cancer. Ursolic acid (UA) is known for its antioxidant, anti-inflammatory, and anticancer properties. However, its impact on cancer cachexia remains unexplored. This study aimed to assess the efficacy of UA in addressing muscle atrophy and organ dysfunction in cancer cachexia and reveal the mechanisms involved. UA dose-dependently ameliorated C2C12 myotube atrophy...
February 27, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38407039/quantitative-metabolomics-and-lipoprotein-analysis-of-pdac-patients-suggests-serum-marker-categories-for-pancreatic-function-pancreatectomy-cancer-metabolism-and-systemic-disturbances
#11
JOURNAL ARTICLE
Gyuntae Bae, Georgy Berezhnoy, Alejandra Flores, Claire Cannet, Hartmut Schäfer, Marc H Dahlke, Patrick Michl, Markus W Löffler, Alfred Königsrainer, Christoph Trautwein
Pancreatic ductal adenocarcinoma (PDAC) is difficult to diagnose in the early stages and lacks reliable biomarkers. The scope of this project was to establish quantitative nuclear magnetic resonance (NMR) spectroscopy to comprehensively study blood serum alterations in PDAC patients. Serum samples from 34 PDAC patients obtained before and after pancreatectomy as well as 83 age- and sex-matched control samples from healthy donors were analyzed with in vitro diagnostics research (IVDr) proton NMR spectroscopy at 600 MHz...
February 26, 2024: Journal of Proteome Research
https://read.qxmd.com/read/38406646/dynamic-changes-in-cardiac-biomarkers-in-radiotherapy-for-oesophageal-cancer-and-their-correlations-with-cardiac-radiation-dosimetry
#12
JOURNAL ARTICLE
Jin-Zhi Wang, Yue Wang, Qian Shao, Jian-Bin Li
BACKGROUND AND PURPOSE: To investigate the dynamic changes in cardiac enzymes, high-sensitivity troponin T (hs-TnT), pro-brain natriuretic peptide (pro-BNP) and left ventricular ejection fraction (LVEF) during radiotherapy (RT) and 6 months after RT for oesophageal squamous cell carcinoma (ESCC) in the middle and lower locations and to analyse the correlations between these indicators and cardiac radiation dosimetry parameters. METHODS: For 35 patients with ESCC in the middle and lower locations receiving radical concurrent chemoradiotherapy (cCRT), intensity-modulated RT was performed at 1...
March 2024: Clinical and Translational Radiation Oncology
https://read.qxmd.com/read/38383436/pembrolizumab-induced-myocarditis-with-complete-atrioventricular-block-and-concomitant-myositis-in-a-metastatic-bladder-cancer-patient-a-case-report-and-review-of-the-literature
#13
REVIEW
R Saad, A Ghaddar, R M Zeenny
BACKGROUND: The cardiovascular system is among the least systems affected by immune-related adverse events. We report a rare life-threatening case of pembrolizumab-induced myocarditis with complete atrioventricular block and concomitant myositis in a metastatic bladder cancer patient. CASE PRESENTATION: An 82-year-old Caucasian female with invasive urothelial carcinoma, started on first-line pembrolizumab, was admitted four days after receiving her second dose for severe asthenia, diffuse muscle aches, neck pain, and lethargy...
February 22, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38364453/clinical-presentation-of-cardiac-symptoms-following-treatment-with-tumor-infiltrating-lymphocytes-diagnostic-challenges-and-lessons-learned
#14
JOURNAL ARTICLE
J S W Borgers, A W van Schijndel, J V van Thienen, S Klobuch, T T P Seijkens, R P Tobin, L van Heerebeek, A Driessen-Waaijer, M W Rohaan, J B A G Haanen
BACKGROUND: Treatment with tumor-infiltrating lymphocytes (TILs) is rapidly evolving for patients with solid tumors. Following metastasectomy, TILs (autologous, intratumoral CD4+ and CD8+ T cells with the potential to recognize tumor-associated antigens) are isolated and non-specifically expanded ex vivo in the presence of interleukin-2 (IL-2). Subsequently, the TILs are adoptively transferred to the patients after a preconditioning non-myeloablative, lymphodepleting chemotherapy regimen, followed by administration of high-dose (HD) IL-2...
February 2024: ESMO Open
https://read.qxmd.com/read/38341962/rna-binding-protein-igf2bp2-suppresses-metastasis-of-clear-cell-renal-cell-carcinoma-by-enhancing-ckb-mrna-stability-and-expression
#15
JOURNAL ARTICLE
Junwu Ren, Bo Huang, Wei Li, Yongquan Wang, Xiaojuan Pan, Qiang Ma, Yuying Liu, Xiaolin Wang, Ce Liang, Yuying Zhang, Shimin Wang, Feifei Yang, Haiping Li, Hao Ning, Yan Jiang, Changhong Qin, Ai Ran, Bin Xiao
Clear cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer, with a highly aggressive phenotype and poor prognosis. RNA binding proteins (RBPs) play crucial roles in post-transcriptional gene regulation and have been implicated in tumorigenesis. RBPs have the potential to become a new therapeutic target for ccRCC. In this study, we screened and validated that insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) as an RBP, was down-regulated in ccRCC tissues and cell lines. Functionally, we verified that IGF2BP2 significantly suppressed the migration and invasion ability of ccRCC in vitro and in vivo...
February 10, 2024: Translational Oncology
https://read.qxmd.com/read/38331249/comparison-of-body-iodine-pool-assessment-methods-before-radioiodine-therapy
#16
JOURNAL ARTICLE
Mustafa Genc, Aslihan Yildirim, Nilufer Yildirim
INTRODUCTION AND OBJECTIVES: Radioactive iodine therapy (RAIT) is recommended to reduce the risk of recurrence and metastasis in patients with intermediate-high risk differentiated thyroid cancer (DTC). In preparation for RAIT, stimulation of thyroid-stimulating hormone and reduction of body iodine pool are important for treatment success. For this purpose, patients are asked to reduce their iodine intake before RAIT, and the body iodine pool can be evaluated by measuring iodine excretion in urine before treatment...
February 6, 2024: Revista española de medicina nuclear e imagen molecular
https://read.qxmd.com/read/38315281/preoperative-low-plasma-creatine-kinase-levels-predict-worse-survival-outcomes-in-bladder-cancer-after-radical-cystectomy
#17
JOURNAL ARTICLE
Yifan Li, Hang Xu, Tianhai Lin, Jiapeng Zhang, Jianzhong Ai, Shiyu Zhang, Weizhen Le, Ping Tan, Peng Zhang, Qiang Wei, Xiaonan Zheng, Lu Yang
BACKGROUND AND AIMS: To evaluate the prognostic significance of preoperative creatine kinase (CK) levels in bladder cancer (BCa) patients who underwent radical cystectomy (RC). MATERIALS AND METHODS: 570 BCa patients with RC were identified between 2010 and 2020. 108.5 U/L of CK levels were defined as the cutoff value. Logistic regression analysis and Cox regression models were performed to evaluate the association between CK levels and oncologic outcomes. Subgroup analyses were performed to address cofounding factors...
February 5, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38292716/the-role-of-hesperidin-as-a-cardioprotective-strategy-against-doxorubicin-induced-cardiotoxicity-the-antioxidant-anti-inflammatory-antiapoptotic-and-cytoprotective-potentials
#18
JOURNAL ARTICLE
Fawiziah Khalaf Alharbi, Zafer S Alshehri, Faez F Alshehri, Sharif Alhajlah, Hesham A Khalifa, Naief Dahran, Wael A M Ghonimi
BACKGROUND: Doxorubicin (DOX), an anthracycline antibiotic, is a powerful chemotherapeutic agent effective against multiple types of cancer, particularly lung, breast, bladder and hematologic neoplasia (lymphomas and leukemia). However, its therapeutic usage is restricted by its known cardiotoxicity, which is associated with the production of oxidative stress. Enhancing antioxidant capacity represents a promising approach to mitigate DOX-induced cardiotoxicity. Hesperidin (HES), a citrus bioflavonoid, possesses several pharmacological effects, such as anti-inflammatory and antioxidant characteristics...
December 2023: Open Veterinary Journal
https://read.qxmd.com/read/38279787/evaluation-of-a-new-cystoscopic-cryocatheter-and-method-for-the-in-situ-destruction-of-bladder-cancer-preliminary-in-vivo-study
#19
JOURNAL ARTICLE
John M Baust, Anthony Corcoran, Anthony Robilotto, Aaron Katz, Kimberly Santucci, Robert G Van Buskirk, John G Baust, Kristi K Snyder
Purpose: To assess the ability to deliver full-thickness bladder wall cryoablation through a cystoscopic approach using a new closed-loop 6F cryocatheter and thermal dose-controlled protocol. Materials and Methods: Evaluations were conducted using a chronic porcine model wherein 10 lesions/animal were created throughout the bladder (bladder wall, trigone region, ureteral orifice, and distal ureter). A 6F cryocatheter was passed through the working channel of a flexible cystoscope. Single 1- and 1.5-minute freeze protocols in a saline environment were evaluated and resultant lesion size was determined...
February 26, 2024: Journal of Endourology
https://read.qxmd.com/read/38270330/dynamic-optical-coherence-tomography-evaluation-in-locally-advanced-basal-cell-carcinoma-during-sonidegib-treatment
#20
JOURNAL ARTICLE
C Cantisani, N Musolff, C Longo, A Di Guardo, E Rovaldi, G Rossi, F Sasso, F Farnetani, F Rega, A Bánvölgyiv, G Azzella, G Paolino, G Pellacani
BACKGROUND: Basal cell carcinoma (BCC) is the most common cancer in the Caucasian population. It has a multifactorial pathogenesis, in which constitutive activation of the Sonic Hedgehog signalling (SHH) pathway (via mutations in PTCH1 or SMO genes) represents by far the most common genetic aberration. The introduction of vismodegib and sonidegib, two SHH pathway inhibitors, changed the therapeutic approach of locally advanced and metastatic BCCs. EADO's (European Association of Dermato-Oncology) new staging system refers to these as 'difficult-to-treat' BCCs...
January 25, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
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