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https://www.readbyqxmd.com/read/27814628/inflammatory-biomarkers-of-coronary-heart-disease
#1
Hongyu Li, Kai Sun, Ruiping Zhao, Jiang Hu, Zhiru Hao, Fei Wang, Yaojun Lu, Fu Liu, Yong Zhang
Coronary heart disease (CHD), characterized by inflammation and accumulation of plaques mainly comprised of lipids, calcium and inflammatory cells in the walls of coronary arteries. CHD is exacerbated by specific cardiovascular risk factors, such as obesity, diabetes mellitus, and hypertension. The current review focuses on the critical role of traditional inflammatory biomarkers, including interleukin-6, C-reactive protein (CRP), complement, CD40 and myeloperoxidase (MPO), in the pathogenesis of CHD.
January 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/27013694/treatment-gaps-in-adults-with-heterozygous-familial-hypercholesterolemia-in-the-united-states-data-from-the-cascade-fh-registry
#2
Emil M deGoma, Zahid S Ahmad, Emily C O'Brien, Iris Kindt, Peter Shrader, Connie B Newman, Yashashwi Pokharel, Seth J Baum, Linda C Hemphill, Lisa C Hudgins, Catherine D Ahmed, Samuel S Gidding, Danielle Duffy, William Neal, Katherine Wilemon, Matthew T Roe, Daniel J Rader, Christie M Ballantyne, MacRae F Linton, P Barton Duell, Michael D Shapiro, Patrick M Moriarty, Joshua W Knowles
BACKGROUND: Cardiovascular disease burden and treatment patterns among patients with familial hypercholesterolemia (FH) in the United States remain poorly described. In 2013, the FH Foundation launched the Cascade Screening for Awareness and Detection (CASCADE) of FH Registry to address this knowledge gap. METHODS AND RESULTS: We conducted a cross-sectional analysis of 1295 adults with heterozygous FH enrolled in the CASCADE-FH Registry from 11 US lipid clinics...
June 2016: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/26947536/significantly-greater-progression-of-intima-media-thickness-of-the-carotid-artery-in-japanese-american-men-than-in-white-men-the-era-jump-study
#3
Vasudha Ahuja, Kamal Masaki, Emma J M Barinas-Mitchell, Beatriz L Rodriguez, Andrew D Althouse, Hirotsugu Ueshima, Abhishek Vishnu, Todd B Seto, Lewis H Kuller, Bradley Wilcox, Akira Sekikawa
BACKGROUND: Although a westernized lifestyle was associated with increased coronary heart disease (CHD), morbidity, and mortality in first- and second-generation Japanese Americans, CHD mortality was reported to be lower in this population than in whites. The risk profile of CHD for third- and fourth-generation Japanese Americans is not known. We compared the progression of carotid intima-media thickness (CIMT) between third- or fourth-generation Japanese Americans and whites. METHODS: Population-based samples of 473 men (Japanese Americans, 227; whites, 246) aged 40-49 years at baseline and free of clinical cardiovascular disease were examined for CIMT at baseline (2004-2007) and follow-up (2007-2013)...
October 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/26930192/twelve-year-cardiovascular-and-mortality-risk-in-relation-to-smoking-habits-in-type-2-diabetic-and-non-diabetic-men-tehran-lipid-and-glucose-study
#4
Farzad Hadaegh, Arash Derakhshan, Amirhossein Mozaffary, Mitra Hasheminia, Davood Khalili, Fereidoun Azizi
INTRODUCTION: To examine the associations between smoking and cardiovascular disease (CVD) / coronary heart disease (CHD) and all-cause mortality events in men with and without type 2 diabetes (T2D) in a Middle Eastern cohort during a median follow-up of 12 years. METHODS: The study population included 2230 subjects aged ≥ 40 years, free from CVD, comprised of 367 participants with diabetes (21.2% current smokers) and 1863 without (27.3% current smokers). Multivariate Hazard ratios (HR) and 95% confidence intervals (CI) were calculated for smoking (considering different definitions) for those with and without diabetes...
2016: PloS One
https://www.readbyqxmd.com/read/26665231/preventing-cardiac-diseases-in-childhood
#5
Andreas Petropoulos, Doris Ehringer-Schetitska, Peter Fritsch, Eero Jokinen, Robert Dalla Pozza, Renate Oberhoffer
OBJECTIVE: The burden of cardiac disease in childhood is unknown. It will be a sum of 1% of living births in the general population, suffering from Congenital Heart Disease (CHD) + approximately 2.5% of the general population suffering from bicuspid aortic valve diseases + an unknown higher prevalence of acquired diseases. Cardiomyopathies, arrhythmias - sudden cardiac death (SCD), rheumatic heard disease, hypertension and accelerating atherosclerosis are among the most frequent. Adding on, genetic syndromes including cardiac defects, endocarditis and myocarditis we can address a large pediatric population worldwide, suffering from heart disease...
September 2015: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/26337107/emerging-vascular-risk-factors-in-women-any-differences-from-men
#6
REVIEW
N Katsiki, D P Mikhailidis
Gender differences have been reported for traditional vascular risk factors such as smoking, obesity, diabetes, hypertension, dyslipidemia, age and family history of premature coronary heart disease. The prevalence, severity, associations and response to treatment of several emerging cardiovascular disease (CVD) risk factors may also differ between men and women. Such CVD risk factors include certain inflammatory and hemostatic markers, endothelial dysfunction, homocysteine, lipid disorders, microalbuminuria/proteinuria, coronary artery calcium score, arterial stiffness, periodontitis, inflammatory bowel syndrome, obstructive sleep apnea, impaired glucose metabolism, metabolic syndrome and non-alcoholic fatty liver disease...
2015: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/26262712/fish-oil-and-vitamin-e-change-lipid-profiles-and-anti-ldl-antibodies-in-two-different-ethnic-groups-of-women-transitioning-through-menopause
#7
Liania Alves Luzia, José Mendes Aldrighi, Nágila Raquel Teixeira Damasceno, Geni Rodrigues Sampaio, Rosana Aparecida Manólio Soares, Isis Tande Silva, Ana Paula De Queiroz Mello, Antonio Augusto Ferreira Carioca, Elizabeth Aparecida Ferraz da Silva Torres
BACKGROUND: studies have investigated the relationship between the transition through menopause and cardiovascular diseases. White population, generally, have lower levels of traditional coronary heart risk factors, particularly dyslipidemia, hypertension, obesity, and diabetes, and lower rates of coronary heart disease mortality, than black population. Furthermore many studies have shown the cardioprotective and anti-inflammatory effects of omega-3 polyunsaturated fatty acids (eicosapentaenoic acid and docosahexaenoic acid) of marine origin...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/26251000/risk-factors-and-markers-for-acute-myocardial-infarction-with-angiographically-normal-coronary-arteries
#8
Maria Daniel, Christina Ekenbäck, Stefan Agewall, Elin B Brolin, Kenneth Caidahl, Kerstin Cederlund, Olov Collste, Lars Eurenius, Mats Frick, Shams Younis-Hassan, Loghman Henareh, Tomas Jernberg, Karin Malmqvist, Jonas Spaak, Peder Sörensson, Claes Hofman-Bang, Per Tornvall
Myocardial Infarction with normal coronary arteries (MINCA) is common with a prevalence of 1% to 12% of all myocardial infarctions. The pathogenic mechanisms of MINCA are still unknown, but endothelial dysfunction has been suggested as a possible cause. To investigate risk factors and markers for MINCA, we conducted a case-control study. Considering the reported low prevalence of classical risk factors for coronary heart disease (CHD) in some but not all studies, our hypothesis was that endothelial function and intima-media thickness (IMT) were better, respectively lower, than CHD controls...
September 15, 2015: American Journal of Cardiology
https://www.readbyqxmd.com/read/26239003/cardiovascular-disease-susceptibility-and-resistance-in-circumpolar-inuit-populations
#9
REVIEW
Maria Tvermosegaard, Inger K Dahl-Petersen, Nina Odgaard Nielsen, Peter Bjerregaard, Marit Eika Jørgensen
Cardiovascular disease (CVD) is a major public health issue in indigenous populations in the Arctic. These diseases have emerged concomitantly with profound social changes over the past 60 years. The aim of this study was to summarize the literature on CVD risk among Arctic Inuit. Literature on prevalence, incidence, and time trends for CVD and its risk factors in Arctic Inuit populations was reviewed. Most evidence supports a similar incidence of coronary heart disease and a higher incidence of cerebrovascular disease among Arctic Inuit than seen in western populations...
September 2015: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/26089010/frequency-of-attainment-of-low-density-lipoprotein-cholesterol-and-non-high-density-lipoprotein-cholesterol-goals-in-cardiovascular-clinical-practice-from-the-national-cardiovascular-data-registry-pinnacle-registry
#10
Sarah A Spinler, Mark J Cziraky, Vincent J Willey, Fengming Tang, Thomas M Maddox, Tyan Thomas, Gladys G Dueñas, Salim S Virani
Studies have found that non-high-density lipoprotein cholesterol (non-HDL-C) is a superior marker for coronary heart disease compared to low-density lipoprotein cholesterol (LDL-C). Little is known about achievement of non-HDL-C goals outside clinical trials. Within a population of 146,064 patients with dyslipidemia in the PINNACLE Registry and a subgroup of 36,188 patients with diabetes mellitus (DM), we examined the proportion of patients and patient characteristics associated with having LDL-C, non-HDL-C, and both LDL-C and non-HDL-C levels at National Cholesterol Education Program goals...
August 15, 2015: American Journal of Cardiology
https://www.readbyqxmd.com/read/26088003/association-between-dietary-pattern-and-risk-of-cardiovascular-disease-among-adults-in-the-middle-east-and-north-africa-region-a-systematic-review
#11
Najlaa Aljefree, Faruk Ahmed
OBJECTIVE: This paper reviews the evidence related to the association of dietary pattern with coronary heart disease (CHD), strokes, and the associated risk factors among adults in the Middle East and North Africa (MENA) region. METHODS: A systematic review of published articles between January 1990 and March 2015 was conducted using Pro-Quest Public Health, MEDLINE, and Google Scholar. The term 'dietary pattern' refers to data derived from dietary pattern analyses and individual food component analyses...
2015: Food & Nutrition Research
https://www.readbyqxmd.com/read/26025183/association-of-lipoprotein-lipase-gene-with-coronary-heart-disease-in-sudanese-population
#12
Muzamil M Abdel Hamid, Safa Ahmed, Awatif Salah, Etayeb M A Tyrab, Lemya M Yahia, Elbagire A Elbashir, Hassan H Musa
Cardiovascular disease is stabilizing in high-income countries and has continued to rise in low-to-middle-income countries. Association of lipid profile with lipoprotein lipase gene was studied in case and control subject. The family history, hypertension, diabetes mellitus, smoking and alcohol consumption were the most risk factors for early-onset of coronary heart disease (CHD). Sudanese patients had significantly (P<0.05) lower TC and LDL-C levels compared to controls. Allele frequency of LPL D9N, N291S and S447X carrier genotype was 4...
December 2015: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/25924966/elevated-blood-lipids-are-uncommon-in-patients-with-post-polio-syndrome-a-cross-sectional-study
#13
Eva Melin, Thomas Kahan, Kristian Borg
BACKGROUND: The post-polio syndrome occurs in people who previously have had poliomyelitis. After the initial recovery, new or increasing neurologic symptoms occur. Inflammation and dyslipidaemia may play an important role in the development of atherosclerotic complications, for example myocardial infarction and angina pectoris. Previous studies on cardiovascular risk factors in the post-polio syndrome have found a higher prevalence of hypertension, ischemic heart disease, hyperlipidaemia, and stroke in these patients...
2015: BMC Neurology
https://www.readbyqxmd.com/read/25880982/the-association-between-triglyceride-high-density-lipoprotein-cholesterol-ratio-and-all-cause-mortality-in-acute-coronary-syndrome-after-coronary-revascularization
#14
Ke Wan, Jianxun Zhao, Hao Huang, Qing Zhang, Xi Chen, Zhi Zeng, Li Zhang, Yucheng Chen
AIMS: High triglycerides (TG) and low high-density lipoprotein cholesterol (HDL-C) are cardiovascular risk factors. A positive correlation between elevated TG/HDL-C ratio and all-cause mortality and cardiovascular events exists in women. However, utility of TG to HDL-C ratio for prediction is unknown among acute coronary syndrome (ACS). METHODS: Fasting lipid profiles, detailed demographic data, and clinical data were obtained at baseline from 416 patients with ACS after coronary revascularization...
2015: PloS One
https://www.readbyqxmd.com/read/25870610/relationship-between-lipoprotein-a-and-micro-macro-complications-in-type-2-diabetes-mellitus-a-forgotten-target
#15
Rocio Toro, Eduardo Segura, Jesús Millan Nuñez-Cortes, Juan Carlos Pedro-Botet, Maribel Quezada-Feijoo, Alipio Mangas
OBJECTIVES: Increased lipoprotein (a) serum concentrations seems to be a cardiovascular risk factor; this has not been confirmed in extracoronary atherosclerosis complications. We therefore wished to gain a deeper insight into relationship between the plasma concentrations of lipoprotein (a) and the micro- and macro-vascular complications of type 2 diabetes mellitus and to identify possible differences in this association. METHODS: This is a descriptive observational cross-sectional study...
March 2015: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/25825692/lipoprotein-particles-and-size-total-and-high-molecular-weight-adiponectin-and-leptin-in-relation-to-incident-coronary-heart-disease-among-severely-obese-postmenopausal-women-the-women-s-health-initiative-observational-study
#16
Rachel H Mackey, Kathleen M McTigue, Yuefang F Chang, Emma Barinas-Mitchell, Rhobert W Evans, Lesley F Tinker, Cora E Lewis, JoAnn E Manson, Marcia L Stefanick, Barbara V Howard, Lawrence S Phillips, Simin Liu, Doina Kulick, Lewis H Kuller
BACKGROUND: We hypothesized that higher concentrations of LDL particles (LDL-P) and leptin, and lower concentrations of HDL particles (HDL-P), and total and high molecular weight (HMW) adiponectin, would predict incident coronary heart disease (CHD) among severely obese postmenopausal women. METHODS: In a case-cohort study nested in the Women's Health Initiative Observational Study, we sampled 677 of the 1852 white or black women with body mass index (BMI) ≥40 kg/m(2) and no prevalent cardiovascular disease (CVD), including all 124 cases of incident CHD over mean 5...
June 2015: BBA Clinical
https://www.readbyqxmd.com/read/25660463/analysis-of-lipid-lowering-therapy-and-factors-affecting-regularity-of-statin-intake-in-patients-with-cardiovascular-disease-enrolled-in-the-profile-registry
#17
Oleg Gaisenok, Sergey Martsevich, Svetlana Tripkosh, Yulia Lukina
OBJECTIVE: The aim of this study was to analyze the quality of lipid-lowering therapy in a cohort of patients with cardiovascular disease enrolled in a Moscow-based registry, and to analyze the factors affecting the regularity of statin administration in this patient category. METHODS: The present study included all patients who successively sought medical advice in the Preventive Pharmacotherapy Department of the Ministry of Healthcare of the Russian Federation between May 1 and December 31, 2011 (n=274)...
February 2015: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/25599530/the-role-of-the-kynurenine-pathway-of-tryptophan-metabolism-in-cardiovascular-disease-an-emerging-field
#18
REVIEW
K A Polyzos, D F J Ketelhuth
Coronary heart disease and stroke, the deadliest forms of cardiovascular disease (CVD), are mainly caused by atherosclerosis, a chronic inflammatory disease of the artery wall driven by maladaptive immune responses in the vessel wall. Various risk factors for CVD influence this pathogenic process, including diabetes mellitus, hypertension, dyslipidaemia, and obesity. Indoleamine 2,3-dioxygenase (IDO), an enzyme catalyzing the rate-limiting step in the kynurenine pathway of tryptophan degradation, is strongly induced by inflammation in several tissues, including the artery wall...
2015: Hämostaseologie
https://www.readbyqxmd.com/read/25591753/-cardiac-and-metabolic-risk-factors-in-severe-mental-disorders-task-of-a-prevention-manager
#19
F Lederbogen, P Schwarz, S Häfner, U Schweiger, M Bohus, M Deuschle
People with severe mental disorders have a reduction in life expectancy of 13-30 % compared with the general population. This severe disadvantage is primarily due to an increased prevalence of cardiac and metabolic disorders, especially coronary heart disease (CHD) and type 2 diabetes mellitus and are the result of untoward health behavior characterized by smoking, low levels of physical activity and unhealthy dietary habits. Obesity, arterial hypertension and lipid disorders are also associated with this behavior and further increase the risk of CHD and type 2 diabetes...
July 2015: Der Nervenarzt
https://www.readbyqxmd.com/read/25536559/radiation-and-non-radiation-factors-and-their-impact-on-the-natural-history-of-coronary-heart-disease-in-chornobyl-accident-clean-up-workers
#20
D O Bilyi, O M Nastina, Zh M Gabulavichene, G V Sydorenko, O D Bazyka, V V Bilaya, O S Kovalyov
The objective of the study was to evaluate the impact of a range of risk factors and ionizing radiation on the severity of clinical presentation of coronary heart disease (CHD) in Chornobyl accident clean-up workers (ACW). Materials and methods. A total of 376 ACW and 123 Kiev city residents with no exposure to radiation participated in the study. Study scope included the case history recording, clinical check-up, electrocardiography (ECG), daily ECG-monitoring, daily arterial blood pressure monitoring, exercise ECG, Doppler ultrasound (Doppler echocardiography), and serum lipid profile assay...
September 2014: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
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