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Mucosal prolapse

Alexandra Gerstgrasser, Hassan Melhem, Irina Leonardi, Kirstin Atrott, Matthias Schäfer, Sabine Werner, Gerhard Rogler, Isabelle Frey-Wagner
BACKGROUND AND AIMS: The transcription factor Nrf2 is a major modulator of the cellular antioxidant response. Oxidative burst of infiltrating macrophages leads to a massive production of reactive oxygen species in inflamed tissue of inflammatory bowel disease patients. This oxidative burst contributes to tissue destruction and epithelial permeability, but it is also an essential part of the antibacterial defense. We therefore investigated the impact of the Nrf2 orchestrated antioxidant response in both acute and chronic intestinal inflammation...
September 28, 2016: Journal of Crohn's & Colitis
T Rautio, J Mäkelä-Kaikkonen, M Vaarala, M Kairaluoma, J Kössi, M Carpelan-Holmström, S Salmenkylä, P Ohtonen, J Mäkelä
BACKGROUND: Laparoscopic ventral rectopexy has been used to treat male patients with external rectal prolapse, but evidence to support this approach is scarce. The aim of this study was to evaluate the results of this new abdominal rectopexy surgical technique in men. METHODS: This was a retrospective multicenter study. Adult male patients who were operated on for external rectal prolapse using ventral rectopexy in five tertiary hospitals in Finland between 2006 and 2014 were included in the study...
October 2016: Techniques in Coloproctology
Sergey V Minaev, Igor V Kirgizov, Aleksander Gladkyy, Ilya Shishkin, Igor Gerasimenko
BACKGROUND: Operative correction of anorectal malformations (ARMs) remains a challenge in pediatric surgery. The study aimed to evaluate the outcomes of laparoscopic treatment of ARM in children. METHODS: From 2007 to 2014, we performed 104 laparoscopic-assisted anorectal pull-through procedures in children with a mean age of 11.3 ± 0.4 months and ARMs. Clinical assessment, surgical durations, complications, and postoperative outcome were investigated. RESULTS: The mean duration of the operation was 126...
August 23, 2016: World Journal of Surgery
Deepa T Patil, Juliana Kissiedu, E Rene Rodriguez, Erinn Downs-Kelly, Xiuli Liu, Lisa A Rybicki, Carmela D Tan
Fibromuscular dysplasia (FMD) is a noninflammatory, nonatherosclerotic vasculopathy that usually affects the carotid and renal arteries. We have observed FMD-like vascular changes in specimens resected for ischemia or Crohn's disease (CD). On the basis of a systematic clinicopathologic review of these 11 cases identified between 1982 and 2014, we describe a distinct mesenteric vasculopathy that involves both arteries and veins [mesenteric arteriovenous dysplasia/vasculopathy (MAVD/V)] and is characterized by (1) concentric/eccentric smooth muscle collarette around the tunica media of both the artery and the vein in ≥2 foci, (2) varying degrees of intimal and medial hyperplasia and adventitial fibrosis, and (3) lack of inflammation or thrombi...
October 2016: American Journal of Surgical Pathology
Bin Quan, Qiyi Chen, Jun Jiang, Ling Ni, Rongrong Tang, Yu Huang, Yifang Shi, Ning Li
OBJECTIVE: To investigate the safety, efficacy and long-term outcomes of Jinling procedure in the treatment of adult Hirschsprung disease. METHODS: Clinical and follow-up data of 125 patients with adult Hirschsprung disease undergoing Jinling procedure at the Department of General Surgery between January 2000 and January 2013 were summarized. All the patients were diagnosed by CT, barium enema, anorectal pressure detection and pathology examination. Abdominal symptoms, gastrointestinal quality of life index(GIQLI, the lower score, the worse quality of life), Wexner constipation score (higher score indicated worse symptom), defecography (evaluation included rectocele, mucosal prolapse, intramucosal intussusception, perineal prolapse) and other operative complications were compared before and after operation...
July 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Weiwei Lu, Xiaofei Zhang, Bingjian Lu
BACKGROUND: Enteric-type glandular lesions are extremely rare in the vagina. Their histological origin remains a matter of speculation at present. METHOD: We review two rectal mucosal prolapse-like polyps and one intestinal-type adenosis in the vagina. RESULTS: Case 1, a 64-year-old woman, presented with a vaginal polypoid lesion with a size of 4 × 3 × 3 cm. Case 2, an 8-year-old girl, had a 1.5 × 1.5 × 0.8-cm pedunculated polyp in the vaginal navicular fossa and a clinically suspected rectovaginal fistula...
2016: Diagnostic Pathology
Saleh M Eftaiha, George Melich, Ajit Pai, Slawomir J Marecik, Leela M Prasad, John J Park
INTRODUCTION: Bowel dysfunction (fecal incontinence and constipation) presents in over 50% of patients after treatment of congenital anal malformations. Sacral nerve stimulation (SNS) for the treatment of fecal incontinence improves function in the majority of patients. We present a case report of the treatment of bowel dysfunction with sacral nerve stimulation in a patient with a history of an imperforate anus. PRESENTATION OF CASE: A twenty year-old female with a history of imperforate anus at birth, repaired during infancy with anorectoplasty, presented with fecal incontinence and constipation...
2016: International Journal of Surgery Case Reports
P De Nardi, A M Tamburini, P G Gazzetta, M Lemma, A Pascariello, C R Asteria
BACKGROUND: The aim of our study was to assess the outcome of hemorrhoidal dearterialization, achieved by a dedicated laser energy device. METHODS: From November 2012 to December 2014, 51 patients with second- or third-degree hemorrhoids were studied. The primary end point was a reduction in the bleeding rate; secondary end points were: postoperative complications, reduction in pain and prolapse, resolution of symptoms, and degree of patient's perception of improvement...
July 2016: Techniques in Coloproctology
Nayden G Naydenov, Alex Feygin, Dongdong Wang, John F Kuemmerle, Gianni Harris, Mary Anne Conti, Robert S Adelstein, Andrei I Ivanov
The actin cytoskeleton is a critical regulator of intestinal mucosal barrier permeability, and the integrity of epithelial adherens junctions (AJ) and tight junctions (TJ). Non muscle myosin II (NM II) is a key cytoskeletal motor that controls actin filament architecture and dynamics. While NM II has been implicated in the regulation of epithelial junctions in vitro, little is known about its roles in the intestinal mucosa in vivo. In this study, we generated a mouse model with an intestinal epithelial-specific knockout of NM IIA heavy chain (NM IIA cKO) and examined the structure and function of normal gut barrier, and the development of experimental colitis in these animals...
2016: Scientific Reports
Maria-Teresa Zedda, Luisa Bogliolo, Federica Ariu, Mauro Ledda, Laura Falchi, Maria-Luisa Pinna-Parpaglia, Salvatore Pau
CASE DESCRIPTION: A 7-year-old 42-kg (92.4-lb) sexually intact nulliparous female Italian Mastiff was examined because of a history of vaginal prolapse during diestrus. CLINICAL FINDINGS: A physical examination revealed vaginal fold prolapse. Abdominal ultrasonography revealed an enlarged uterus with hypoechogenic content, corpora lutea in the ovaries, and a cyst in the right ovary. Hematologic abnormalities included leukocytosis, neutrophilia, mild anemia, and low Hct...
April 1, 2016: Journal of the American Veterinary Medical Association
Luis Antonio Hidalgo Grau, Neus Ruiz Edo, Sara Llorca Cardeñosa, Adolfo Heredia Budó, Óscar Estrada Ferrer, Marta Del Bas Rubia, Eva María García Torralbo, Xavier Suñol Sala
INTRODUCTION: Circular mucosal anopexy (CMA) achieves a more comfortable postoperative period than resective techniques. But complications and recurrences are not infrequent. This study aims to evaluate of the efficacy of CMA in the treatment of hemorrhoids and rectal mucosal prolapse (RMP). METHOD: From 1999 to 2011, 613 patients underwent surgery for either hemorrhoids or RMP in our hospital. CMA was performed in 327 patients. Gender distribution was 196 male and 131 female...
May 2016: Cirugía Española
Thilo Wedel, Martina Barrenschee, Christina Lange, François Cossais, Martina Böttner
Diverticula of the colon are pseudodiverticula defined by multiple outpouchings of the mucosal and submucosal layers penetrating through weak spots of the muscle coat along intramural blood vessels. A complete prolapse consists of a diverticular opening, a narrowed neck, and a thinned diverticular dome underneath the serosal covering. The susceptibility of diverticula to inflammation is explained by local ischemia, translocation of pathogens due to retained stool, stercoral trauma by fecaliths, and microperforations...
April 2015: Viszeralmedizin
Neha Salaria, Naveen Sharma, Uma Garg, Swaran Kaur Saluja, Ruchi Agarwal
INTRODUCTION: Nasal polyps are benign prolapsed mucosal lesions which commonly arise from the paranasal sinuses and lateral walls of the nose especially the contact areas of osteomeatal complex. Though nasal polyps arising from the nasal septum have been reported, those arising from its anterior part are extremely rare and present a diagnostic dilemma. Aetiology is multifactorial and is mainly a result of the inflammatory response of the lining mucosa. CASE REPORT: The case of a 28-year-old male, with a history of progressively increasing nasal complaints since 4 months and with a nasal mass arising from the anterior nasal septum on examination, is reported...
July 2015: Iranian Journal of Otorhinolaryngology
Amanullah Abbasi, Abdul Rabb Bhutto, Ali Taj, Aurangzaib, Akhtar Baloch, Muhammad Masroor, S M Munir
OBJECTIVE: To assess the demographic, clinical, endoscopic and histological spectrum of Solitary Rectal Ulcer Syndrome (SRUS). STUDY DESIGN: Cross-sectional observational study. PLACE AND DURATION OF STUDY: Medical Unit-III, Civil Hospital Karachi (CHK) and Ward 7, Jinnah Postgraduate Medical Centre (JPMC), Karachi, from January 2009 to June 2012. METHODOLOGY: Patients with SRUS, based on characteristic endoscopic and histological findings, were enrolled...
December 2015: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Karim Awad, Mohamed El Debeiky, Amr AbouZeid, Ayman Albaghdady, Tarek Hassan, Sameh Abdelhay
BACKGROUND: Several techniques have been described for the surgical correction of rectal prolapse without any clear advantage for one technique over the other. We evaluated the use of laparoscopic suture rectopexy (LSRP) as a modality of treatment for rectal prolapse in children. MATERIALS AND METHODS: Prospective data were collected for all children who presented to our center between 2011 and 2014 and required surgery for rectal prolapse. All children underwent LSRP with fixation of the mobilized rectum to the sacral promontory with multiple nonabsorbable sutures...
April 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Samson Tou, Steven R Brown, Richard L Nelson
BACKGROUND: Complete (full-thickness) rectal prolapse is a lifestyle-altering disability that commonly affects older people. The range of surgical methods available to correct the underlying pelvic floor defects in full-thickness rectal prolapse reflects the lack of consensus regarding the best operation. OBJECTIVES: To assess the effects of different surgical repairs for complete (full-thickness) rectal prolapse. SEARCH METHODS: We searched the Cochrane Incontinence Group Specialised Register up to 3 February 2015; it contains trials from the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, MEDLINE in process, ClinicalTrials...
2015: Cochrane Database of Systematic Reviews
Mohammad-Hossein Sarmast, Shahnam Askarpour, Mehran Peyvasteh, Hazhir Javaherizadeh, Meisam Mooghehi-Nezhad
INTRODUCTION: Prolapse of the rectum is the herniation of the rectum through the anus, which may be categorised as mucosal or complete. AIM: To evaluate the clinical manifestation, treatment, and surgical complications of children with rectal prolapse over a 6-year period. MATERIAL AND METHODS: This study was carried out on children aged < 14 years who were admitted or referred for rectal prolapse that failed to respond after medical treatment in Imam Khomeini and Abouzar Children's Hospital...
2015: Przegla̜d Gastroenterologiczny
F Gaj, L Candeloro, I Biviano
BACKGROUND AND AIMS: Our experience in colon-proctology showed the need to update the post-surgical complications score we published (1), adding others that may have an impact on outcome of treatment. The aim of this study was to assess the efficacy of a score obtained from the analysis of the quality of life and severity of complications after proctologic surgery. MATERIALS AND METHODS: Between January and December 2013, we studied 150 patients undergoing several ano-rectal surgeries for the presence of hemorrhoids of grade III and IV (63 patients), anal fissures (42 patients), anal fistulas (19 patients), rectocele (15 patients) and mucosal prolapse of the rectum (11 patients)...
2015: La Clinica Terapeutica
F Gaj, I Biviano, G Sportelli, L Candeloro
OBJECTIVES: Hemorrhoids are a very common condition. The treatment depends upon persistence and severity of symptoms. For hemorrhoids of II and III grade the rubber band ligation may be therapeutic. Our aim is to report the outcomes of rubber band ligation of hemorrhoids, with a follow up of 6 months. MATERIALS AND METHODS: A total of 50 patients underwent rubber band ligation for symptomatic hemorrhoids (grade II and III) without prolapse, between June 2012 and June 2014...
2015: La Clinica Terapeutica
Sheng-Long Li, Fang-Yan Jing, Li-Li Ma, Li-Li Guo, Feng Na, Sheng-Li An, Yan Ye, Jun-Ming Yang, Ming Bao, Dong Kang, Xiao-Lan Sun, Yong-Jian Deng
BACKGROUND: The etiology and pathogenesis of hemorrhoids is unclear, although hemorrhoids are a worldwide disease in men and women, with peak prevalence at 45-65 years of age. Hemorrhoidal cushions as the anal venous plexi are normal anatomical structures from infancy. This study attempts to reveal the angiodysplasia and other pathological changes in association with different degrees of symptomatic hemorrhoids. MATERIALS AND METHODS: A total of 281 patients with internal hemorrhoids from degree I to IV underwent hemorrhoidectomy...
2015: Drug Design, Development and Therapy
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