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https://www.readbyqxmd.com/read/28339928/opioid-use-in-chronic-pain-patients-with-chronic-kidney-disease-a-systematic-review
#1
Vittal R Nagar, Pravardhan Birthi, Sara Salles, Paul A Sloan
Objectives. : To investigate the prevalence of chronic pain and opioid management among patients with chronic kidney disease (CKD). Design.:  Systematic review. Methods.:  A systematic search was performed, including citations from 1960 to May 2015. The review highlights methodological quality assessment of the selected studies; prevalence of pain; type, dose, and reason for opioid use; effectiveness of pain control and associated adverse effects of opioids in CKD patients...
March 2, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339339/use-of-dietary-supplements-improved-diet-quality-but-not-cardiovascular-and-nutritional-biomarkers-in-socioeconomically-diverse-african-american-and-white-adults
#2
Marie Fanelli Kuczmarski, May A Beydoun, Emily Stave Shupe, Ryan T Pohlig, Alan B Zonderman, Michele K Evans
Knowledge of the contribution of supplements to overall nutritional health is limited. The research objectives were to describe motivations for use of dietary supplements by African Americans and Whites examined in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study and to determine if supplements provided beneficial effects to micronutrient diet quality and nutritional and cardiovascular biomarkers. The majority of the HANDLS study population were smokers, overweight or obese, and self-reported their health as poor to good...
March 24, 2017: Journal of Nutrition in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28334108/fast-admixture-analysis-and-population-tree-estimation-for-snp-and-ngs-data
#3
Yu Jade Cheng, Thomas Mailund, Rasmus Nielsen
Structure methods are highly used population genetic methods for classifying individuals in a sample fractionally into discrete ancestry components. We introduce a new optimization algorithm for the classical STRUCTURE model in a maximum likelihood framework. Using analyses of real data we show that the new method finds solutions with higher likelihoods than the state-of-the-art method inthe same computational time. The optimization algorithm is also applicable to models based on genotype likelihoods, that can account for the uncertainty in genotype-calling associated with Next Generation Sequencing (NGS) data...
February 17, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28333983/alterations-in-amino-acid-status-in-cats-with-feline-dysautonomia
#4
Bruce C McGorum, Herb W Symonds, Clare Knottenbelt, Tom A Cave, Susan J MacDonald, Joanna Stratton, Irene Leon, Judith A Turner, R Scott Pirie
Feline dysautonomia (FD) is a multiple system neuropathy of unknown aetiology. An apparently identical disease occurs in horses (equine grass sickness, EGS), dogs, rabbits, hares, sheep, alpacas and llamas. Horses with acute EGS have a marked reduction in plasma concentrations of the sulphur amino acids (SAA) cyst(e)ine and methionine, which may reflect exposure to a neurotoxic xenobiotic. The aim of this study was to determine whether FD cats have alterations in amino acid profiles similar to those of EGS horses...
2017: PloS One
https://www.readbyqxmd.com/read/28333975/is-the-number-of-siblings-associated-with-dietary-patterns-in-adolescents-the-1993-birth-cohort-of-pelotas-brazil
#5
F O Meller, M C F Assunção, A A Schäfer, C Loret de Mola, D L Dahly, J S Vaz, F C Barros
Our study aimed to estimate the association between number of siblings and dietary patterns in adolescents. Prospective longitudinal study was developed using data from the birth cohort of the city of Pelotas, Brazil, which included 5249 participants. At the 18-year-old follow-up, from 4563 individuals located, 4106 were interviewed (follow-up rate 81.3%). Of these, 3751 were included in our principal component analysis of dietary patterns. Regular dietary intake of 45 food groups over the previous year was measured with a food frequency questionnaire...
2017: PloS One
https://www.readbyqxmd.com/read/28333575/is-clinical-measurement-of-anatomic-axis-of-the-femur-adequate
#6
Chi-Chuan Wu
Background and purpose - The accuracy of using clinical measurement from the anterior superior iliac spine (ASIS) to the center of the knee to determine an anatomic axis of the femur has rarely been studied. A radiographic technique with a full-length standing scanogram (FLSS) was used to assess the adequacy of the clinical measurement. Patients and methods - 100 consecutive young adult patients (mean age 34 (20-40) years) with chronic unilateral lower extremity injuries were studied. The pelvis and intact contralateral lower extremity images in the FLSS were selected for study...
March 23, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28333354/men-s-knowledge-attitudes-and-behaviours-relating-to-fertility
#7
Karin Hammarberg, Veronica Collins, Carol Holden, Kate Young, Robert McLachlan
BACKGROUND: The increasingly common practice in high-income countries to delay childbearing to the fourth and fifth decades of life increases the risk of involuntary childlessness or having fewer children than desired. Older age also increases the risk of age-related infertility, the need for ART to conceive, and obstetric and neonatal complications. Existing research relating to childbearing focusses almost exclusively on women, and in public discourse declining fertility rates are often assumed to be the result of women delaying childbearing to pursue other life goals such as a career and travel...
March 10, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28333201/new-statistical-criteria-detect-phylogenetic-bias-caused-by-compositional-heterogeneity
#8
David A Duchêne, Sebastian Duchêne, Simon Y W Ho
In statistical phylogenetic analyses of DNA sequences, models of evolutionary change commonly assume that base composition is stationary through time and across lineages. This assumption is violated by many data sets, but it is unclear whether the magnitude of these violations is sufficient to mislead phylogenetic inference. We investigated the impacts of compositional heterogeneity on phylogenetic estimates using a method for assessing model adequacy. Based on a detailed simulation study, we found that common frequentist criteria are highly conservative, such that the model is often rejected when the phylogenetic estimates do not show clear signs of bias...
February 21, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28333089/south-asian-ethnicity-is-related-to-the-highest-risk-of-vitamin-b12-deficiency-in-pregnant-canadian-women
#9
Marta Jeruszka-Bielak, Carly Isman, Theresa H Schroder, Wangyang Li, Tim J Green, Yvonne Lamers
Vitamin B12 (B12) adequacy during pregnancy is crucial for maternal health and optimal fetal development; however, suboptimal B12 status has been reported in pregnant Canadian women. Methylmalonic acid (MMA) is a sensitive indicator of B12 status. Since few studies have measured MMA during pregnancy in Canadian women, the objective of this study was to evaluate B12 status in pregnant women living in Metro Vancouver, using both plasma total B12 and MMA. We recruited a convenience sample of 320 pregnant women between 20 and 35 gestational weeks from local healthcare facilities...
March 23, 2017: Nutrients
https://www.readbyqxmd.com/read/28332888/clinician-and-patient-acceptability-of-self-collected-human-papillomavirus-testing-for-cervical-cancer-screening
#10
Constance Mao, Shalini L Kulasingam, Hilary K Whitham, Stephen E Hawes, John Lin, Nancy B Kiviat
BACKGROUND: To evaluate clinician and patient attitudes toward home self-collected human papillomavirus (HPV) testing for cervical cancer screening. METHODS: Women aged 21-65 years were recruited for a randomized trial comparing home self-collected HPV testing to standard clinician-collected Pap screening. Participants were surveyed about their attitudes toward self-collected HPV testing. Clinicians performing cervical cancer screening in University of Washington medical clinics were also surveyed to determine their acceptability of self-collected HPV testing...
March 23, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28331937/whey-protein-and-albumin-effects-upon-urinary-risk-factors-for-stone-formation
#11
Camila Mithie Hattori, Hans-Göran Tiselius, Ita Pfeferman Heilberg
Protein supplements are consumed for an expected increase in muscle mass and improved exercise performance, but as their impact on lithogenic parameters are unknown, we aimed to evaluate the effects of Whey protein (WP) and Albumin upon the risk factors for nephrolithiasis. WP or Albumin supplements (one scoop/day) were administered for 3 days to 18 healthy volunteers, with 1-week washout period between them. Serum and 24-h urine samples were collected at baseline and after completing each intervention. All participants were asked to replicate their baseline diet during the subsequent urine collection...
March 22, 2017: Urolithiasis
https://www.readbyqxmd.com/read/28330460/sepsis-recognition-in-the-emergency-department-impact-on-quality-of-care-and-outcome
#12
Marius Morr, Alexander Lukasz, Eva Rübig, Hermann Pavenstädt, Philipp Kümpers
BACKGROUND: Appropriate and timely recognition of sepsis is a prerequisite for starting goal-directed therapy bundles. We analyzed the appropriateness of sepsis recognition and documentation with regard to adequacy of therapy and outcome in an internal medicine emergency department (ED). METHODS: This study included 487 consecutive patients ≥18 years of age who presented to a university hospital ED during a 4-week period. Clinical, laboratory, and follow-up data were acquired independently from documentation by ED physicians...
March 23, 2017: BMC Emergency Medicine
https://www.readbyqxmd.com/read/28329819/development-of-a-physical-environmental-observational-tool-for-dining-environments-in-long-term-care-settings
#13
Habib Chaudhury, Heather Keller, Kaylen Pfisterer, Lillian Hung
Purpose: This paper presents the first standardized physical environmental assessment tool titled Dining Environment Audit Protocol (DEAP) specifically designed for dining spaces in care homes and reports the results of its psychometric properties. Items rated include: adequacy of lighting, glare, personal control, clutter, staff supervision support, restraint use, and seating arrangement option for social interaction. Two scales summarize the prior items and rate the overall homelikeness and functionality of the space...
February 20, 2017: Gerontologist
https://www.readbyqxmd.com/read/28329716/-i-ll-do-anything-to-maintain-my-health-how-women-aged-65-94-perceive-experience-and-cope-with-their-aging-bodies
#14
Erica V Bennett, Laura Hurd Clarke, Kent C Kowalski, Peter R E Crocker
We explored how physically active women perceived, experienced, and coped with their aging bodies, and examined their perceptions of the utility of self-compassion to manage aging body-related changes. Findings from a thematic analysis of interviews with 21 women aged 65-94 revealed that they were appreciative of how their bodies worked and accepting of their physical limitations, yet concurrently critical of their body's functionality and appearance. Participants engaged in physical activity and healthy eating to maintain their health and body functionality, yet also used diet, hair styling, anti-aging creams, makeup, physical activity, and clothing to manage their appearances...
March 19, 2017: Body Image
https://www.readbyqxmd.com/read/28327480/pharmacotherapy-of-patients-with-stable-bronchial-asthma
#15
REVIEW
Ashutosh Nath Aggarwal
Several reliever and controller medications are available for managing patients with stable asthma. Inhaled corticosteroids (ICS) are the mainstay of treatment, and can be combined with long-acting beta-agonists (LABA) for patients with moderate or severe disease. An ICS-LABA combination is best administered as a single inhaler used for both maintenance and emergency use. A stepwise approach to therapy has recently been proposed as part of Indian guidelines for management of asthma. Clinicians should advise proper use of inhaled medications, and step up or step down treatment based on adequacy of asthma control...
November 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/28327139/association-of-admission-and-patient-characteristics-with-quality-of-discharge-letters-posthoc-analysis-of-a-retrospective-study
#16
Maaike Langelaan, Rebecca J Baines, Martine C de Bruijne, Cordula Wagner
BACKGROUND: A complete, correct and timely discharge letter can communicate important information from the hospital to the general practitioner. The adequacy of the letter may vary with the patient and admission characteristics of the patient. Insight in the association between these characteristics and the presence and quality of the discharge letter will give rise to improvement activities for a better continuity of care after discharge. The objective was to determine the presence, correctness and timeliness of admission information in discharge letters and to determine the association between patient and admission characteristics, including unplanned readmissions and the quality of the discharge letter...
March 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28327077/regional-muscle-tissue-saturation-is-an-indicator-of-global-inadequate-circulation-during-cardiopulmonary-bypass-a-randomized-porcine-study-using-muscle-intestinal-and-brain-tissue-metabolomics
#17
Sisse Anette Thomassen, Benedict Kjærgaard, Preben Sørensen, Jan Jesper Andreasen, Anders Larsson, Bodil Steen Rasmussen
BACKGROUND: Muscle tissue saturation (StO2) measured with near-infrared spectroscopy has generally been considered a measurement of the tissue microcirculatory condition. However, we hypothesized that StO2 could be more regarded as a fast and reliable measure of global than of regional circulatory adequacy and tested this with muscle, intestinal and brain metabolomics at normal and two levels of low cardiopulmonary bypass blood flow rates in a porcine model. METHODS: Twelve 80 kg pigs were connected to normothermic cardiopulmonary bypass with a blood flow of 60 mL/kg/min for one hour, reduced randomly to 47...
April 2017: Perfusion
https://www.readbyqxmd.com/read/28325811/a-theoretical-and-practical-approach-to-defining-adequate-oxygenation-in-the-preterm-newborn
#18
REVIEW
Chad C Andersen, Nicolette A Hodyl, Haresh M Kirpalani, Michael J Stark
John Scott Haldane recognized that the administration of supplemental oxygen required titration in the individual. Although he made this observation in adults, it is equally applicable to the preterm newborn. But how, in practice, can the oxygen requirements in the preterm newborn be determined to avoid the consequences of too little and too much oxygen? Unfortunately, the current generation of oxygen saturation trials in preterm newborns guides saturation thresholds rather than individual oxygen requirements...
March 21, 2017: Pediatrics
https://www.readbyqxmd.com/read/28323080/validation-of-the-spanish-version-of-the-quality-of-dying-and-death-questionnaire-qodd-esp-in-a-home-based-cancer-palliative-care-program-and-development-of-the-qodd-esp-12
#19
Pedro E Pérez-Cruz, Oslando Padilla Pérez, Pilar Bonati, Oliva Thomsen Parisi, Laura Tupper Satt, Marcela Gonzalez Otaiza, Diego Ceballos Yáñez, Armando Maldonado Morgado
CONTEXT: Improving quality of death (QOD) is a key goal in palliative care. To our knowledge, no instruments to measure QOD have been validated in Spanish. OBJECTIVES: The goals of this study were to validate the Spanish version of the quality of dying and death questionnaire (QODD) and to develop and validate a shortened version of this instrument by phone interview. METHODS: We enrolled caregivers of consecutive deceased cancer patients who participated in a single palliative care clinic...
March 16, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28320232/evaluation-of-the-adequacy-of-hadlock-s-reference-chart-for-identification-of-fetuses-with-growth-restriction
#20
Ana Lúcia de Freitas Alves, Ana Alice Vidal de Carvalho, José Antônio Bastos de Carvalho, Israel Figueiredo
OBJECTIVE: This study aimed to verify whether Hadlock's reference values for fetal weight identify fetuses below the 10th percentile in our population correctly. METHODS: The fitness of the Hadlock reference range to our study population was tested by assessment of Z scores. We evaluated differences between the reference weight ranges proposed in our study and those recommended by Hadlock. RESULTS: Z scores for Hadlock reference values were non-normally distributed...
March 21, 2017: Journal of Maternal-fetal & Neonatal Medicine
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