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Chemoradiation

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https://www.readbyqxmd.com/read/28633765/neck-dissection-for-unknown-cancer-of-the-head-and-neck-in-the-era-of-chemoradiation
#1
Mark J Amsbaugh, Mehran Yusuf, Jeremy Gaskins, Craig Silverman, Kevin Potts, Jeffrey Bumpous, Rebecca Redman, Cesar Perez, Neal Dunlap
PURPOSE: To report outcomes for patients with cervical lymph node metastases from an unknown primary site of the head and neck treated with either non-operative therapy or neck dissection followed by adjuvant therapy. MATERIALS AND METHODS: All patients with squamous cell carcinoma of an unknown primary site of the head or neck seen between 2003 and 2013 were reviewed. The Kaplan-Meier method was used to estimate overall survival, local recurrence free survival, loco-regional recurrence free survival, and progression free survival...
June 14, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28633596/laparotomy-site-implantation-metastasis-of-carcinoma-of-the-papilla-of-vater
#2
Milan Radojkovic, Jasmina Gligorijevic, Miroslav Stojanovic, Goran Stanojevic, Ivan Ilic
Introduction Carcinomas of the papilla of Vater make up a heterogeneous group of tumours arising from different types of epithelium. Regional lymph nodes, liver and lungs are the primary sites of metastatic progression of these tumours. Case presentation We present a patient with an abdominal incision site metastasis of low-grade (mixed type) adenocarcinoma of the papilla of Vater one year after pylorus-preserving pancreaticoduodenectomy. Implantation metastasis of low-grade ampullary carcinoma in the laparotomy wound after open Whipple's procedure is unusual...
January 1, 2017: Scottish Medical Journal
https://www.readbyqxmd.com/read/28633248/endobronchial-guided-vascularized-tissue-flaps-for-a-bronchopleural-fistula
#3
Sarah M Elswick, Basel Sharaf, Ziyad S Hammoudeh, Ali I Saeed, Eric S Edell, David E Midthun, Shanda H Blackmon
The management of bronchopleural fistulas can be challenging. The initial treatment is usually conservative, but operative intervention with transposition of vascularized pedicled flaps may be required in refractory cases. We present the case of a 67-year-old man with stage IIIa squamous cell carcinoma of the lung who underwent a lower and middle bilobectomy after receiving neoadjuvant chemoradiation. His postoperative course was complicated by empyema and a bronchopleural fistula. Because of difficulty accessing the fistula, endobronchial-guided vascularized tissue flaps were successfully used to close the fistula...
July 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28628563/recurrence-risk-stratification-after-preoperative-chemoradiation-of-esophageal-adenocarcinoma
#4
Mian Xi, Christopher L Hallemeier, Kenneth W Merrell, Zhongxing Liao, Mariela A Blum Murphy, Linus Ho, Wayne L Hofstetter, Reza Mehran, Jeffrey H Lee, Manoop S Bhutani, Brian Weston, Dipen M Maru, Ritsuko Komaki, Jaffer A Ajani, Steven H Lin
OBJECTIVE: To discern recurrence risk stratification and investigate its influence on postoperative surveillance in patients with esophageal adenocarcinoma (EAC) after neoadjuvant chemoradiotherapy (CRT). BACKGROUND: Reports documenting recurrence risk stratification in EAC after neoadjuvant CRT are scarce. METHODS: Between 1998 and 2014, 601 patients with EAC who underwent neoadjuvant CRT followed by esophagectomy were included for analysis...
June 16, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28628423/current-considerations-for-low-level-laser-therapy-photobiomodulation-therapy-in-the-management-of-side-effects-of-chemoradiation-therapy-for-cancer
#5
Kenji Yoshida
No abstract text is available yet for this article.
June 19, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28628354/soft-tissue-enhancement-and-implant-placement-following-partial-mandibulectomy-due-to-squamous-cell-carcinoma
#6
Fabio Bernardello, Giampietro Bertasi, Ralph Mackey Powers, Sergio Spinato, Andrea Viaggi, Jimmie Bullock, Pietro Felice
Many dental procedures allow for implant placement in partially or totally edentulous patients. Despite the availability of various implant and abutment types on the market, it often becomes quite challenging to achieve the biological and esthetic goals in a patient who has ridge deficiencies. Where problems will arise is from the lack of adequate bone quality and quantity.1,2 Soft tissue form and maintenance is also a consideration to evaluate.3 Primary reconstructive techniques following segmental mandibulectomy is evolving and improves quality of life...
June 19, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/28627602/molecular-profiling-of-locally-advanced-rectal-adenocarcinoma-using-microrna-expression-review
#7
Cory Pettit, Steve Walston, Patrick Wald, Amy Webb, Terence M Williams
Treatment for locally-advanced rectal cancer (LARC) typically consists of neoadjuvant chemoradiation followed by total mesorectal excision. Recently, there has been growing interest in non-operative management for patients who are medically-inoperable or wish to avoid surgical morbidity and permanent colostomy. Approximately 50% of patients who receive pre-operative neoadjuvant chemoradiation develop some degree of pathologic response. Approximately 10-20% of patients are found to have a complete pathologic response, a finding which has frequently been shown to predict better clinical outcomes, including local-regional control, distant metastasis and survival...
June 14, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28626581/carcinosarcoma-of-the-maxillary-sinus-a-rare-case-report
#8
Jawad Hasnaoui, Said Anajar, Mohammed Tatari, Reda Abada, Sami Rouadi, Mohammed Roubal, Mohammed Mahtar
INTRODUCTION: Carcinosarcoma is a highly malignant tumor characterized by dual malignant histologic differentiation of epithelial and mesenchymal components. The tumor is extremely rare in the sinonasal tract, with only 13 cases reported since 1957 in the literature. PRESENTATION OF CASE: We report a case of a 55-year-old man with right-sided face pain revealed a mass in the right maxillary sinus and nasal cavity. A large incisional biopsy from the nasal cavity concluded the diagnosis of carcinosarcoma...
July 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28626256/postoperative-chemoradiation-therapy-using-high-dose-cisplatin-and-fluorouracil-for-high-and-intermediate-risk-uterine-cervical-cancer
#9
Rise Miyauchi, Yoshiyuki Itoh, Mariko Kawamura, Akihiro Hirakawa, Kiyosumi Shibata, Hiroaki Kajiyama, Rie Nakahara, Seiji Kubota, Junji Ito, Tohru Okada, Fumitaka Kikkawa, Shinji Naganawa
The purpose of this retrospective study was to analyze data in patients with stage IB-IIB uterine cervical cancer who were treated with concurrent chemoradiotherapy (CCRT) with high dose cisplatin and fluorouracil as postoperative adjuvant therapy. Between February 2003 and November 2011, 76 patients with FIGO stage IB-IIB cervical cancer were analyzed. Seventy patients were treated with postoperative CCRT and 6 patients were treated with radiation therapy alone. Data related to overall survival (OS), disease-free survival (DFS), toxicity, and failure pattern were analyzed...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28625632/a-population-based-comparative-effectiveness-study-of-chemoradiation-regimens-and-sequences-in-stage-iii-non-small-cell-lung-cancer
#10
Jeremy P Harris, Manali I Patel, Billy W Loo, Heather A Wakelee, Maximilian Diehn
OBJECTIVES: In patients receiving concurrent chemoradiation for locally advanced non-small cell lung cancer (NSCLC), consolidation chemotherapy is frequently given even though several randomized trials have failed to show a benefit. We explored the potential benefits of consolidation chemotherapy using a population-based comparative effectiveness approach. MATERIALS AND METHODS: Surveillance, Epidemiology, and End Results-Medicare was used to identify patients with Stage III NSCLC aged ≥65 and diagnosed 2002-2009...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28622248/quantitative-perfusion-analysis-of-the-rectum-using-golden-angle-radial-sparse-parallel-magnetic-resonance-imaging-initial-experience-and-comparison-to-time-resolved-angiography-with-interleaved-stochastic-trajectories
#11
Ulrike I Attenberger, Jing Liu, Philipp Riffel, Johannes Budjan, Robert Grimm, Kai T Block, Stefan O Schoenberg, Xiaoying Wang, Daniel Hausmann
OBJECTIVES: Purpose of this study was to compare the quality of perfusion maps obtained from prototypical free-breathing magnetic resonance imaging (MRI) with continuous golden-angle radial sampling and iterative reconstruction (GRASP) to conventional acquisition using time-resolved angiography with interleaved stochastic trajectories (TWIST) in patients with rectal cancer. MATERIAL AND METHODS: Forty cases were included for retrospective analysis. Twenty of the patients received routine multiparametric MRI at 3 T for rectal cancer staging, including perfusion measurement with GRASP or TWIST (10 patients for each technique, including 5 prechemoradiation and 5 postchemoradiation)...
June 16, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28621885/multiagent-induction-chemotherapy-followed-by-chemoradiation-is-associated-with-improved-survival-in-locally-advanced-pancreatic-cancer
#12
Anna Torgeson, Shane Lloyd, Dustin Boothe, Randa Tao, Jonathan Whisenant, Ignacio Garrido-Laguna, George M Cannon
BACKGROUND: The role of chemoradiotherapy (CRT) in locally advanced pancreatic cancer (LAPC) is uncertain after multiple randomized clinical trials have yielded mixed results. The authors used the National Cancer Database (NCDB) to determine whether CRT yields a survival benefit compared with chemotherapy alone (CT). METHODS: Patients with nonmetastatic LAPC diagnosed during 2004 through 2014 were identified in the NCDB. Patients who received CT were compared with those who received CRT using chi-square analysis...
June 16, 2017: Cancer
https://www.readbyqxmd.com/read/28620930/prospective-multimodal-imaging-assessment-of-locally-advanced-cervical-cancer-patients-administered-by-chemoradiation-followed-by-radical-surgery-the-price-prospective-imaging-of-cervical-cancer-and-neoadjuvant-treatment-study-the-role-of-ultrasound
#13
A C Testa, G Ferrandina, F Moro, T Pasciuto, M C Moruzzi, I De Blasis, F Mascilini, E Foti, R Autorino, A Collarino, B Gui, G F Zannoni, M A Gambacorta, A L Valentini, V Rufini, G Scambia
OBJECTIVE: Chemoradiation-based neoadjuvant treatment followed by radical surgery is an alternative therapeutic strategy for locally advanced cervical cancer (LACC) -stage ≥ IB2 (except of IIA1)- but ultrasound variables used to predict neoadjuvant partial response are not well defined. The goal of this study was to prospectively analyze the potential role of transvaginal ultrasound (TVUS) in early predicting pathologically assessed residual disease in a large, single-institution series of LACC patients triaged to neoadjuvant treatment followed by radical surgery...
June 16, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28620675/sphincter-preserving-surgery-for-low-rectal-cancers-incidence-and-risk-factors-for-permanent-stoma
#14
Joanna Chung Kiu Mak, Dominic Chi Chung Foo, Rockson Wei, Wai Lun Law
BACKGROUND: Advances in surgical techniques and paradigm changes in rectal cancer treatment have led to a drastic decline in the abdominoperineal resection rate, and sphincter-preserving operation is possible in distal rectal cancer. OBJECTIVE: The aim of this study is to evaluate the long-term incidence of permanent stoma after sphincter-preserving surgery for low rectal cancer and its corresponding risk factors. METHOD: From 2000 to 2014, patients who underwent sphincter-preserving low anterior resection for low rectal cancer (within 5 cm from the anal verge) were included...
June 15, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28617687/preoperatively-assessable-clinical-and-pathological-risk-factors-for-parametrial-involvement-in-surgically-treated-figo-stage-ib-iia-cervical-cancer
#15
Emel Canaz, Eser Sefik Ozyurek, Baki Erdem, Merve Aldikactioglu Talmac, Ipek Yildiz Ozaydin, Ozgur Akbayir, Ceyhun Numanoglu, Volkan Ulker
OBJECTIVE: Determining the risk factors associated with parametrial involvement (PMI) is of paramount importance to decrease the multimodality treatment in early-stage cervical cancer. We investigated the preoperatively assessable clinical and pathological risk factors associated with PMI in surgically treated stage IB1-IIA2 cervical cancer. METHODS: A retrospective cohort study of women underwent Querleu-Morrow type C hysterectomy for cervical cancer stage IB1-IIA2 from 2001 to 2015...
June 14, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28614211/mixed-gonadal-germ-cell-tumor-composed-of-a-spermatocytic-tumor-like-component-and-germinoma-arising-in-gonadoblastoma-in-a-phenotypic-woman-with-a-46-xx-peripheral-karyotype-report-of-the-first-case
#16
Alejandro A Gru, Eli S Williams, Dengfeng Cao
We report a unique case of gonadal mixed germ cell tumor (GCT) composed of a predominantly spermatocytic tumor (ST)-like component and a minor component of germinoma arising in gonadoblastoma in a phenotypic woman with a 46, XX peripheral karotype. The patient was a 24-year-old woman (gravida 2, para 1) found to have a 7 cm pelvic mass during routine obstetric ultrasound examination at 20 weeks gestational age. She underwent a left salpingo-gonadectomy at gestational age 23 and 2/7 weeks. She recovered well and delivered a healthy baby at full term...
June 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28612202/management-of-unresectable-locally-advanced-pancreatic-adenocarcinoma
#17
REVIEW
M Salgado, S Arévalo, O Hernando, A Martínez, R Yaya, M Hidalgo
The diagnosis of unresectable locally advanced pancreatic adenocarcinoma (LAPC) requires confirmation, through imaging tests, of the unfeasibility of achieving a complete surgical resection, in the absence of metastatic spread. The increase in overall survival (OS), together with an appropriate symptom management is the therapeutic target in LAPC, maintaining an acceptable quality of life and, if possible, increasing the time until the appearance of metastasis. Chemoradiation (CRT) improves OS compared to best support treatment or radiotherapy (RT) but with greater toxicity...
June 13, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28608731/survival-outcomes-in-patients-with-t2n0m0-stage-ii-squamous-cell-carcinoma-of-the-larynx
#18
Danielle L Gainor, Emily Marchiano, Emily Bellile, Matthew E Spector, Jeremy M G Taylor, Gregory T Wolf, Norman D Hogikyan, Mark E Prince, Carol R Bradford, Avraham Eisbruch, Francis Worden, Andrew G Shuman
Objective Emerging data have demonstrated suboptimal outcomes among patients with stage II larynx cancer. Our objective is to report survival outcomes for T2N0M0 larynx cancer and to determine the cause-specific survival. Study Design Case series with planned data collection. Setting Tertiary academic center. Subjects Adults with T2N0M0 squamous cell carcinoma of the larynx treated with curative intent. Methods A head and neck cancer epidemiology database was queried for eligible subjects from 2003 to 2014...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28608151/quality-of-life-among-survivors-of-early-stage-cervical-cancer-in-taiwan-an-exploration-of-treatment-modality-differences
#19
Chia-Chun Li, Ting-Chang Chang, Yun-Fang Tsai, Lynn Chen
PURPOSE: Women with early-stage cervical cancer may experience changes in their quality of life (QoL) due to treatment or to the effects of the cancer. In this study, we examined differences in QoL by treatment modality between women who underwent surgery only and those treated with concurrent chemoradiation (CCRT). METHODS: The sample of 290 women had been diagnosed with stage I-II cervical cancer. Data were collected on these women's demographic and disease characteristics, general QoL, and cancer-specific QoL using an author-designed demographic-disease survey, the European Organization for Research and Treatment of Cancer QoL questionnaire, and the Taiwanese-version Cervical Cancer Module 24 questionnaire, respectively...
June 12, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28607817/a-rare-case-report-of-mixed-olfactory-neuroblastoma-carcinoma-with-review-of-literature
#20
Charandeep S Gandhoke, Aditi Dewan, Divya Gupta, Simran K Syal, Anita Jagetia, Ravindra K Saran, Ravi Meher, Arvind K Srivastava, Daljit Singh
BACKGROUND: Olfactory neuroblastoma (ONB) is a rare malignant neuroectodermal tumor of the nasal cavity. Mixed olfactory neuroblastoma which contains areas of divergent differentiation is even rare. Till date, only 4 cases of mixed olfactory neuroblastomas have been reported. CASE DESCRIPTION: We report the case of a 46-year-old male who presented with the chief complaints of nasal bleeding and nasal obstruction since 4 months. Radiological imaging was suggestive of a large heterogeneous mass in the left superior nasal cavity with extensions into bilateral maxillary, ethmoidal, and sphenoidal sinuses, as well as into the anterior cranial fossa...
2017: Surgical Neurology International
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