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Chemoradiation

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https://www.readbyqxmd.com/read/28449527/invited-editorial-on-the-timing-of-surgery-after-neoadjuvant-chemoradiation-in-locally-advanced-non-small-cell-lung-cancer
#1
EDITORIAL
Deniz Yalman
No abstract text is available yet for this article.
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28448650/inferior-survival-rates-after-chemoradiation-for-rectal-cancer-without-surgery-reply
#2
C Tyler Ellis, Hanna Sanoff, Karyn B Stitzenberg
No abstract text is available yet for this article.
April 27, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28448642/inferior-survival-rates-after-chemoradiation-for-rectal-cancer-without-surgery
#3
Angelita Habr-Gama, Guilherme Pagin São Julião, Rodrigo O Perez
No abstract text is available yet for this article.
April 27, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28447003/salvage-esophagectomy-for-persistent-or-recurrent-disease-after-definitive-chemoradiation
#4
Stephen G Swisher, Jenifer Marks, David Rice
Locoregionally advanced esophageal cancer is treated by some oncologists with definitive chemoradiation. The optimal strategy to treat persistent or recurrent disease after definitive chemoradiation is controversial. We reviewed the literature to determine current treatment options and optimal approaches. Salvage esophagectomy of relapsed or recurrent esophageal cancer has traditionally been associated with increased risk. Modern literature, however, suggests that in specialized high volume centers the risk of salvage esophagectomy when accompanied with various risk-reducing approaches (anastomosis in non-radiated esophagus, omental transposition, selective use of alternative conduits and two stage procedures) is similar to planned esophagectomy after neoadjuvant chemoradiation...
March 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28446998/pathology-of-esophageal-cancer-and-barrett-s-esophagus
#5
REVIEW
Shilpa Jain, Sadhna Dhingra
Esophageal cancer is a serious malignancy with high mortality. The two common distinctive pathologic subtypes of esophageal cancer are squamous cell carcinoma and adenocarcinoma. These differ with regards to etiology, ethnic distribution, pathogenesis, and location in the esophagus. The precursor lesions are also unique to each subtype. Squamous cell carcinoma is more common in East Asia, is linked to smoking and tobacco use, more commonly involves the middle esophagus, and the precursor lesion is squamous dysplasia...
March 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28446984/salvage-surgery-after-high-dose-radiotherapy
#6
REVIEW
Annemie Van Breussegem, Jeroen M Hendriks, Patrick Lauwers, Paul E Van Schil
Salvage surgery is a relatively new entity in thoracic surgery and oncology. Salvage resection after radiotherapy refers to surgery as only remaining therapeutic option in patients who were treated with high-dose stereotactic radiotherapy (SRT) for early-stage lung cancer or full-dose chemoradiation for locally advanced lung cancer. Indications include locally progressive tumors, recurrent local or locoregional disease, or specific complications after radiotherapy such as lung abscesses or infected, necrotic cavities...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28441255/european-society-of-gynaecological-oncology-guidelines-for-the-management-of-patients-with-vulvar-cancer
#7
Maaike H M Oonk, François Planchamp, Peter Baldwin, Mariusz Bidzinski, Mats Brännström, Fabio Landoni, Sven Mahner, Umesh Mahantshetty, Mansoor Mirza, Cordula Petersen, Denis Querleu, Sigrid Regauer, Lukas Rob, Roman Rouzier, Elena Ulrikh, Jacobus van der Velden, Ignace Vergote, Linn Woelber, Ate G J van der Zee
OBJECTIVE: The aim of this study was to develop clinically relevant and evidence-based guidelines as part of European Society of Gynaecological Oncology's mission to improve the quality of care for women with gynecologic cancers across Europe. METHODS: The European Society of Gynaecological Oncology Council nominated an international development group made of practicing clinicians who provide care to patients with vulvar cancer and have demonstrated leadership and interest in the management of patients with vulvar cancer (18 experts across Europe)...
May 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28440876/triple-modality-treatment-in-patients-with-advanced-stage-tonsil-cancer
#8
Dylan F Roden, David Schreiber, Babak Givi
BACKGROUND: Concurrent chemoradiation (CCRT) and upfront surgery followed by adjuvant therapy both are recommended treatment options for patients with advanced stage squamous cell carcinoma (SCC) of the tonsil. To the authors' knowledge, the question of whether surgical-based treatments can achieve better survival compared with CCRT has never been compared in a clinical trial. The authors analyzed the National Cancer Data Base to measure the impact of different treatment modalities on overall survival (OS)...
April 25, 2017: Cancer
https://www.readbyqxmd.com/read/28438289/impact-of-fraction-size-on-locally-advanced-oropharyngeal-and-nasopharyngeal-cancers-treated-with-chemoradiation
#9
Michael T Spiotto, Matthew Koshy
OBJECTIVES: Although chemoradiation regimens have used various fraction sizes, it remains unclear how differences in fraction size impact outcomes. MATERIALS AND METHODS: Using the National Cancer Database, we identified patients with nasopharynx or oropharynx cancers treated between 2004 and 2012 with chemoradiation using fraction sizes of 1.8Gy (n=1612), 2Gy (n=8092) or 2.12Gy (n=1660). Comparisons between fraction sizes were made in the entire cohort and in a propensity matched cohort...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28436197/magnetic-resonance-imaging-following-neoadjuvant-chemoradiation-and-transanal-endoscopic-microsurgery-for-rectal-cancer
#10
Guilherme P São Julião, Cinthia Denise Ortega, Bruna Borba Vailati, Angelita Habr-Gama, Laura Melina Fernandez, Joaquim Gama-Rodrigues, Sergio Eduardo Araujo, Rodrigo O Perez
AIM: Full thickness local excision after neoadjuvant chemoradiotherapy (CRT) for patients with rectal cancer and incomplete clinical response has been a treatment strategy for organ preservation. Follow up of these patients is challenging since anatomic distortion and postoperative changes may be clinically indistinguishable from tumor recurrence. Magnetic resonance imaging (MRI) may have a role in detecting recurrence. The aim of this study is to describe the MRI findings during follow-up in patients having local excision following CRT with and without local recurrence...
April 24, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28435647/helical-tomotherapy%C3%A2-is-a-safe-and-feasible-technique-for-total-scalp-irradiation
#11
Francesco Cuccia, Vanessa Figlia, Antonella Palmeri, Francesco Verderame, Antonio Lo Casto, Mariella Mannino, Giuseppe Ferrera
Angiosarcoma of the scalp is a rare aggressive tumor that affects elderly patients. Chemoradiation is the treatment of choice for multicentric and extensive disease. The shape of the scalp represents a dosimetric challenge in terms of achieving a homogeneous concave dose distribution with coverage of the entire target volume and an acceptable organs-at-risk sparing. We report a case of an 81-year-old man with a multifocal angiosarcoma of the scalp treated with Helical TomoTherapy® (Accuray Inc., Sunnyvale, CA, USA) intensity modulated radiotherapy...
March 24, 2017: Rare Tumors
https://www.readbyqxmd.com/read/28435470/downregulation-of-sirt7-by-5-fluorouracil-induces-radiosensitivity-in-human-colorectal-cancer
#12
Ming Tang, Xiaopeng Lu, Chaohua Zhang, Changzheng Du, Linlin Cao, Tianyun Hou, Zhiming Li, Bo Tu, Ziyang Cao, Yinglu Li, Yongcan Chen, Lu Jiang, Hui Wang, Lina Wang, Baohua Liu, Xingzhi Xu, Jianyuan Luo, Jiadong Wang, Jin Gu, Haiying Wang, Wei-Guo Zhu
5-Fluorouracil (5-FU) combined with radiotherapy is a common treatment strategy to treat human cancers, but the underlying mechanisms of this combination treatment remain unclear. Here, we report that NAD(+)-dependent deacetylase sirtuin-7 (SIRT7) protein levels were decreased due to 5-FU exposure rendering colorectal cancer cells sensitive to radiation. We found that SIRT7 downregulation was mediated via a Tat-binding Protein 1 (TBP1) proteasome-dependent pathway. Specifically, TBP1 was dephosphorylated at tyrosine 381 upon 5-FU treatment, which enhanced its direct interaction with SIRT7 and targeted it for degradation...
2017: Theranostics
https://www.readbyqxmd.com/read/28435398/the-changes-of-tumour-vascular-endothelial-growth-factor-expression-after-neoadjuvant-chemoradiation-in-patients-with-rectal-adenocarcinoma
#13
David Buka, Josef Dvorak, Veronika Sitorova, Igor Sirak, Rene Voboril, Bohuslav Melichar, Igor Richter
AIM OF THE STUDY: The aim was to examine the effects of neoadjuvant chemoradiotherapy on VEGF expression in patients with locally advanced rectal cancer. MATERIALS AND METHODS: A total of 53 patients with locally advanced rectal cancer were retrospectively studied. Neoadjuvant treatment comprised external beam radiation (50.4 Gy/28 fractions) with continuous infusion of 5-fluorouracil. Four to 6 weeks after the chemoradiotherapy, the patients underwent surgical resection...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28434215/long-term-survival-in-stage-iv-esophageal-adenocarcinoma-with-chemoradiation-and-serial-endoscopic-cryoablation
#14
Zachary Spiritos, Parit Mekaroonkamol, Bassel F El- Rayes, Seth D Force, Steven A Keilin, Qiang Cai, Field F Willingham
Esophageal cancer has a poor overall prognosis and is frequently diagnosed at a late stage. Conventional treatment for metastatic esophageal cancer involves chemotherapy and radiation. Local disease control plays a significant role in improving survival. Endoscopic spray cryotherapy is a novel modality that involves freezing and thawing to produce local ablation of malignant tissue via ischemic mechanisms. Spray cryotherapy has been shown to be effective, particularly for early T-stage, superficial esophageal adenocarcinomas...
April 24, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28433254/does-adjuvant-therapy-improve-overall-survival-for-stage-ia-b-pancreatic-adenocarcinoma
#15
Katherine T Ostapoff, Emmanuel Gabriel, Kristopher Attwood, Boris W Kuvshinoff, Steven J Nurkin, Steven N Hochwald
BACKGROUND: Current guidelines recommend adjuvant chemotherapy for resected pancreatic adenocarcinoma (PDAC). However, no studies have addressed its survival benefit for stage I patients as they comprise <10% of PDAC. METHODS: Using the NCDB 2006-2012, resected PDAC patients with stage I disease who received adjuvant therapy (chemotherapy or chemoradiation) were analyzed. Factors associated with overall survival (OS) were identified. RESULTS: 3909 patients with resected stage IA or IB PDAC were identified...
April 19, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28429525/induction-chemotherapy-ict-followed-by-radiochemotherapy-for-locally-advanced-head-and-neck-cancer-as-an-individual-treatment-approach-feasibility-safety-and-retrospective-survival-analysis-in-twenty-three-patients
#16
C-J Busch, J Girke, S Tribius, L Bussmann, R Knecht, P Schafhausen, B B Lörincz, A Münscher
Head and neck squamous cell carcinoma (HNSCC) patients with locoregionally advanced disease usually require multi-modality treatment including surgery, chemotherapy, and radiotherapy. Currently, cisplatin-based concurrent chemoradiation (CRT) remains the gold-standard for these patients [1]. Induction chemotherapy (ICT) prior to definitive therapy is regarded as an effective approach to shrink locally advanced disease allowing more effective and less toxic therapy, to select patients for organ preservation, to improve radiotherapy effectiveness, and also to potentially decrease the risk of distant metastasis due to initial systemic exposure [2]...
April 21, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28428908/metastatic-squamous-cell-carcinoma-of-colon-from-esophageal-cancer
#17
Natasha Garg, Constance Stoehr, Yan Shi Zhao, Heather Rojas, Chung-Tsen Hsueh
BACKGROUND: Esophageal cancer including squamous cell carcinoma (SCC) and adenocarcinoma represents 4% of all cancers in the United States. Patients with esophageal cancer frequently present with locally advanced disease, and about 40% of patients have evidence of metastatic disease on presentation. Common sites of metastasis include liver, lung and bone. Here, we present a rare case of colonic metastasis from primary esophageal SCC. CASE PRESENTATION: A 60-year-old Caucasian male with a history of 20-pack-year cigarette smoking received surgery and adjuvant chemoradiotherapy for locally advanced SCC of larynx...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/28428149/local-control-and-toxicity-of-adaptive-radiotherapy-using-weekly-ct-imaging-results-from-the-lartia-trial-in-stage-iii-nsclc
#18
Sara Ramella, Michele Fiore, Sonia Silipigni, Maria Cristina Zappa, Massimo Jaus, Antonio Maria Alberti, Paolo Matteucci, Elisabetta Molfese, Patrizia Cornacchione, Carlo Greco, Lucio Trodella, Edy Ippolito, Rolando Maria D'Angelillo
INTRODUCTION: Anatomical change of tumor during radiotherapy contributes to target missing. However, in case of tumor shrinkage adaptation of volume could results in an increased incidence of recurrences in the area of target reduction. This study aims to investigate the incidence of failure of adaptive approach and in particular the risk of local recurrence in the area excluded after replanning. METHODS: In this prospective study, LA-NSCLC patients treated with concomitant chemoradiation underwent weekly chest-CT simulation during treatment...
April 17, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28428019/radiation-therapy-for-oropharyngeal-squamous-cell-carcinoma-executive-summary-of-an-astro-evidence-based-clinical-practice-guideline
#19
David J Sher, David J Adelstein, Gopal K Bajaj, David M Brizel, Ezra E W Cohen, Aditya Halthore, Louis B Harrison, Charles Lu, Benjamin J Moeller, Harry Quon, James W Rocco, Erich M Sturgis, Roy B Tishler, Andy Trotti, John Waldron, Avraham Eisbruch
PURPOSE: To present evidence-based guidelines for the treatment of oropharyngeal squamous cell carcinoma (OPSCC) with definitive or adjuvant radiation therapy (RT). METHODS AND MATERIALS: The American Society for Radiation Oncology convened the OPSCC Guideline Panel to perform a systematic literature review investigating the following key questions: (1) When is it appropriate to add systemic therapy to definitive RT in the treatment of OPSCC? (2) When is it appropriate to deliver postoperative RT with and without systemic therapy following primary surgery for OPSCC? (3) When is it appropriate to use induction chemotherapy in the treatment of OPSCC? (4) What are the appropriate dose, fractionation, and volume regimens with and without systemic therapy in the treatment of OPSCC? RESULTS: Patients with stage IV and stage T3 N0-1 OPSCC treated with definitive RT should receive concurrent high-dose intermittent cisplatin...
April 11, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28426673/lymph-node-volume-predicts-survival-but-not-nodal-clearance-in-stage-iiia-iiib-nsclc
#20
Vishesh Agrawal, Thibaud P Coroller, Ying Hou, Stephanie W Lee, John L Romano, Elizabeth H Baldini, Aileen B Chen, David Kozono, Scott J Swanson, Jon O Wee, Hugo J W L Aerts, Raymond H Mak
BACKGROUND: Locally advanced non-small cell lung cancer (LA-NSCLC) patients have poorer survival and local control with mediastinal node (N2) tumor involvement at resection. Earlier assessment of nodal burden could inform clinical decision-making prior to surgery. This study evaluated the association between clinical outcomes and lymph node volume before and after neoadjuvant therapy. MATERIALS AND METHODS: CT imaging of patients with operable LA-NSCLC treated with chemoradiation and surgical resection was assessed...
2017: PloS One
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