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https://www.readbyqxmd.com/read/28110399/safinamide-a-review-in-parkinson-s-disease
#1
Hannah A Blair, Sohita Dhillon
Safinamide (Xadago(®)) is an orally active, selective, reversible monoamine oxidase-B inhibitor with both dopaminergic and non-dopaminergic (glutamatergic) properties. In the EU, safinamide is approved for the treatment of mid- to late-stage fluctuating Parkinson's disease (PD) as add-on therapy to a stable dose of levodopa alone or in combination with other PD medications. Safinamide 50-100 mg/day administered as a fixed or flexible dose significantly increased daily 'on' time without dyskinesia (primary endpoint) in patients with mid- to late-stage PD with motor fluctuations in 24-week, placebo-controlled clinical trials...
January 21, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28110391/social-media-for-patients-benefits-and-drawbacks
#2
REVIEW
Ivan De Martino, Rocco D'Apolito, Alexander S McLawhorn, Keith A Fehring, Peter K Sculco, Giorgio Gasparini
PURPOSE OF REVIEW: Social media is increasingly utilized by patients to educate themselves on a disease process and to find hospital, physicians, and physician networks most capable of treating their condition. However, little is known about quality of the content of the multiple online platforms patients have to communicate with other potential patients and their potential benefits and drawbacks. RECENT FINDINGS: Patients are not passive consumers of health information anymore but are playing an active role in the delivery of health services through an online environment...
January 21, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28110382/economic-evaluations-alongside-efficient-study-designs-using-large-observational-datasets-the-pleasant-trial-case-study
#3
Matthew Franklin, Sarah Davis, Michelle Horspool, Wei Sun Kua, Steven Julious
BACKGROUND: Large observational datasets such as Clinical Practice Research Datalink (CPRD) provide opportunities to conduct clinical studies and economic evaluations with efficient designs. OBJECTIVES: Our objectives were to report the economic evaluation methodology for a cluster randomised controlled trial (RCT) of a UK NHS-delivered public health intervention for children with asthma that was evaluated using CPRD and describe the impact of this methodology on results...
January 21, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28110265/comparative-effectiveness-of-two-disparate-policies-on-child-health-experimental-evidence-from-the-philippines
#4
John W Peabody, Stella Quimbo, Jhiedon Florentino, Riti Shimkhada, Xylee Javier, David Paculdo, Dean Jamison, Orville Solon
BACKGROUND  : Should health systems invest more in access to care by expanding insurance coverage or in health care services including improving the quality of care? Comparing these options experimentally would shed light on the impact and cost-effectiveness of these strategies. METHODS  : The Quality Improvement Demonstration Study (QIDS) was a randomized policy experiment conducted across 30 districts in the Philippines. The study had a control group and two policy intervention groups intended to improve the health of young children...
January 20, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28110224/emotional-intelligence-and-coping-strategies-as-determinants-of-quality-of-life-in-depressed-patient-caregiver-dyads-an-actor-partner-interdependence-analysis
#5
L Boyer, K Baumstarck, M Alessandrini, Z Hamidou, J Testart, M Serres, P Arquillière, P Auquier, T Leroy, X Zendjidjian
OBJECTIVE: Patients with major depressive disorder (MDD) and their natural caregivers experience major lifestyle difficulties. Little is known concerning dyadic (i.e., patient and natural caregiver) characteristics' impact on quality of life. In a sample of depressed patient-caregiver dyads, we examined quality of life (QoL) levels compared with the general population and whether QoL is influenced by emotional intelligence (EI) and coping strategies using the actor-partner interdependence model (APIM)...
January 8, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28110208/inflammatory-pathway-genes-associated-with-inter-individual-variability-in-the-trajectories-of-morning-and-evening-fatigue-in-patients-receiving-chemotherapy
#6
Fay Wright, Marilyn Hammer, Steven M Paul, Bradley E Aouizerat, Kord M Kober, Yvette P Conley, Bruce A Cooper, Laura B Dunn, Jon D Levine, Gail DEramo Melkus, Christine Miaskowski
Fatigue, a highly prevalent and distressing symptom during chemotherapy (CTX), demonstrates diurnal and interindividual variability in severity. Little is known about the associations between variations in genes involved in inflammatory processes and morning and evening fatigue severity during CTX. The purposes of this study, in a sample of oncology patients (N=543) with breast, gastrointestinal (GI), gynecological (GYN), or lung cancer who received two cycles of CTX, were to determine whether variations in genes involved in inflammatory processes were associated with inter-individual variability in initial levels as well as in the trajectories of morning and evening fatigue...
January 19, 2017: Cytokine
https://www.readbyqxmd.com/read/28110207/the-effect-of-physical-activity-on-depressive-symptoms-and-quality-of-life-among-elderly-nursing-home-residents-randomized-controlled-trial
#7
Neslihan Lok, Sefa Lok, Muammer Canbaz
OBJECTIVES: Physical activity may have positive effects on decreasing anxiety, stress and depression, maintaining mental health and ensuring psychological vitality.This study aimed to determine how a "Physical Activity Program" for elderly people in nursing homes affected their depressive symptoms and quality of life. METHODS: We included 80 individuals aged >65years (40 in the intervention group, 40 controls) in this experimental, randomized, controlled pretest-posttest study...
January 16, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28110112/verbal-memory-functioning-moderates-psychotherapy-treatment-response-for-ptsd-related-nightmares
#8
J Cobb Scott, Gerlinde Harb, Janeese A Brownlow, Jennifer Greene, Ruben C Gur, Richard J Ross
Posttraumatic stress disorder (PTSD) is associated with cognitive deficits in attention, executive control, and memory, although few studies have investigated the relevance of cognitive difficulties for treatment outcomes. We examined whether cognitive functioning and history of traumatic brain injury (TBI) were associated with response to cognitive-behavioral therapy (CBT) for PTSD-related sleep problems. In a randomized controlled trial of Imagery Rehearsal (IR) added to components of CBT for Insomnia (IR + cCBT-I) compared to cCBT-I alone for PTSD-related recurrent nightmares, 94 U...
January 13, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28110085/encoding-preparation-and-implementation-of-novel-complex-verbal-instructions
#9
Carlos González-García, Juan E Arco, Ana F Palenciano, Javier Ramírez, María Ruz
Verbal instructions allow humans to acquire and implement complex novel rules in few seconds. A major question that remains elusive is how the brain represents this information prior to successful task execution. In this experiment, we studied the brain regions involved in representing categorical stimulus information during the encoding of novel instructions, their preparation and also their implementation, as well as the relation of the fidelity of these representations to observable behavior. To do so, we devised a novel instructions paradigm to delimitate these three stages...
January 18, 2017: NeuroImage
https://www.readbyqxmd.com/read/28110011/distributions-of-persistent-organic-contaminants-in-sediments-and-their-potential-impact-on-macrobenthic-faunal-community-of-the-geum-river-estuary-and-saemangeum-coast-korea
#10
Seo Joon Yoon, Seongjin Hong, Bong-Oh Kwon, Jongseong Ryu, Chang-Hee Lee, Jungho Nam, Jong Seong Khim
Over the last 30 years, the Geum River Estuary and Saemangeum Coast have been subject to major environmental changes, including dike construction, reclamation, and development of industrial complexes. This study aimed to: 1) investigate the occurrence of polycyclic aromatic hydrocarbons (PAHs), alkylphenols (APs), and styrene oligomers (SOs), 2) identify the sources of sedimentary organic matter, and 3) determine key environmental factors controlling the macrozoobenthos community structure. A total of 58 surface sediments were collected from the estuary and coastal area in 2014...
January 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28110005/concentrations-sources-and-human-health-risk-of-inhalation-exposure-to-air-toxics-in-edmonton-canada
#11
Md Aynul Bari, Warren B Kindzierski
With concern about levels of air pollutants in recent years in the Capital Region of Alberta, an investigation of ambient concentrations, sources and potential human health risk of hazardous air pollutants (HAPs) or air toxics was undertaken in the City of Edmonton over a 5-year period (2009-2013). Mean concentrations of individual HAPs in ambient air including volatile organic compounds (VOCs), polycyclic aromatic hydrocarbons (PAHs) and trace metals ranged from 0.04 to 1.73 μg/m(3), 0.01-0.54 ng/m(3), and 0...
January 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/28109988/epilepsy-and-restless-legs-syndrome
#12
James D Geyer, Emery E Geyer, Zachary Fetterman, Paul R Carney
OBJECTIVE: Restless legs syndrome (RLS) is a common neurological movement disorder occurring in approximately 10% of the general population. The prevalence of moderately severe RLS is 2.7% overall (3.7% for women and 1.7% for men). Epilepsy is also a common neurological disorder with significant associated morbidity and impact on quality of life. We evaluated the severity and frequency of primary RLS in patients with localization-related temporal lobe epilepsy (TLE) and investigated the role of prodromal RLS symptoms as a warning sign and lateralizing indicator...
January 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28109917/assessment-of-collagen-quality-associated-with-non-enzymatic-cross-links-in-human-bone-using-fourier-transform-infrared-imaging
#13
F N Schmidt, E A Zimmermann, G M Campbell, G E Sroga, K Püschel, M Amling, S Y Tang, D Vashishth, B Busse
Aging and many disease conditions, most notably diabetes, are associated with the accumulation of non-enzymatic cross-links in the bone matrix. The non-enzymatic cross-links, also known as advanced glycation end products (AGEs), occur at the collagen tissue level, where they are associated with reduced plasticity and increased fracture risk. In this study, Fourier-transform infrared (FTIR) imaging was used to detect spectroscopic changes associated with the formation of non-enzymatic cross-links in human bone collagen...
January 18, 2017: Bone
https://www.readbyqxmd.com/read/28109762/higher-modified-charlson-index-scores-are-associated-with-increased-incidence-of-complications-transfusion-events-and-length-of-stay-following-revision-hip-arthroplasty
#14
Nikita Lakomkin, Vadim Goz, Claudette M Lajam, Richard Iorio, Joseph A Bosco
BACKGROUND: Revision total hip arthroplasty (RHA) has been associated with greater morbidity and length of stay (LOS) compared to primary total hip arthroplasty. Despite this, few validated metrics exist for risk stratification in RHA cohorts. The Charlson Comorbidity Index (CCI) has been associated with complications in total hip arthroplasty, but its utility in revision surgery remains unexplored. The purpose of this study was to examine the relationship between preoperative CCI and a variety of outcome metrics following RHA...
November 17, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28109760/effectiveness-of-constrained-liner-use-during-harrington-hip-reconstruction-in-oncology-patient
#15
Deren T Bagsby, L Daniel Wurtz
BACKGROUND: Patients with destructive acetabular lesions are at high risk for morbidity. Harrington described reinforcing acetabular diseased bone with methylmethacrylate, supplemented by metal fixation, to allow total hip reconstruction. However, all published studies using this technique report dislocations. We believe that initial use of constrained liners would help alleviate dislocation risk, without increasing component loosening or polyethylene wear. METHODS: Sixty-eight patients who underwent Harrington hip arthroplasties for metastatic cancer from August 2005 to March 2015 were identified...
November 27, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28109700/a-low-energy-set-up-for-gamma-ray-spectrometry-of-norm-tailored-to-the-needs-of-a-secondary-smelting-facility
#16
G Lutter, I Vandael Schreurs, T Croymans, W Schroeyers, S Schreurs, M Hult, G Marissens, H Stroh, F Tzika
A measurement station dedicated for quantitative radiological characterisation of naturally occurring radionuclides in a metallurgical company and based on gamma-ray spectrometry was developed. The station is intended for performing quality control of final non-ferrous metal products and for radiological checks of incoming materials. A low-background point-contact HPGe-detector was used and the signal was split in two branches to enable collecting simultaneously spectra with high amplification (for gamma-ray energies below 250keV) and low amplification...
December 27, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28109579/reprint-of-neuropsychiatric-symptoms-behavioural-disorders-and-quality-of-life-in-parkinson-s-disease
#17
REVIEW
Roberta Balestrino, Pablo Martinez-Martin
Parkinson's disease is a complex neurodegenerative disorder characterized by motor and non-motor symptoms, with neuropsychiatric manifestations among the most frequent non-motor symptoms. Health-related quality of life is a patient-reported outcome that reflects the impact of the disease on physical, mental, and social wellbeing, and on other aspects of patient' life. Although older studies on health-related quality of life in Parkinson's disease mainly investigated the role of the motor impairment, recent research focused on non-motor symptoms has highlighted the critical role that behavioural disturbances due to neuropsychiatric symptoms play in determining health related quality of life...
January 12, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28109439/deep-profiling-of-proteome-and-phosphoproteome-by-isobaric-labeling-extensive-liquid-chromatography-and-mass-spectrometry
#18
B Bai, H Tan, V R Pagala, A A High, V P Ichhaporia, L Hendershot, J Peng
Mass spectrometry-based proteomics has experienced an unprecedented advance in comprehensive analysis of proteins and posttranslational modifications, with particular technical progress in liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) and isobaric labeling multiplexing capacity. Here, we introduce a deep proteomics profiling protocol that combines 10-plex tandem mass tag (TMT) labeling with an optimized LC-MS/MS platform to quantitate whole proteome and phosphoproteome. The major steps include protein extraction and digestion, TMT labeling, two-dimensional liquid chromatography, TiO2-mediated phosphopeptide enrichment, high-resolution mass spectrometry, and computational data processing...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28109411/the-challenge-in-improving-the-diets-of-supplemental-nutrition-assistance-program-recipients-a-historical-commentary
#19
EDITORIAL
Barry M Popkin
This paper provides a historical background for the current nutrition issues faced by the Supplemental Nutrition Assistance Program (SNAP). The Food Stamp Program evolved into SNAP during a period when U.S. diets, particularly those of the poor, became less healthful. During the 1960s, the U.S. (Kennedy-Johnson era) addressed malnutrition first with a pilot project focused on retail sales and cash food stamps, which showed that low-income consumers purchased relatively healthy foods for a fairly high-quality diet...
February 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28109409/ecco-essential-requirements-for-quality-cancer-care-soft-tissue-sarcoma-in-adults-and-bone-sarcoma-a-critical-review
#20
REVIEW
Elisabeth Andritsch, Marc Beishon, Stefan Bielack, Sylvie Bonvalot, Paolo Casali, Mirjam Crul, Roberto Delgado- Bolton, Davide Maria Donati, Hassan Douis, Rick Haas, Pancras Hogendoorn, Olga Kozhaeva, Verna Lavender, Jozsef Lovey, Anastassia Negrouk, Philippe Pereira, Pierre Roca, Godelieve Rochette de Lempdes, Tiina Saarto, Bert van Berck, Gilles Vassal, Markus Wartenberg, Wendy Yared, Alberto Costa, Peter Naredi
BACKGROUND: ECCO essential requirements for quality cancer care (ERQCC) are checklists and explanations of organisation and actions that are necessary to give high-quality care to patients who have a specific tumour type. They are written by European experts representing all disciplines involved in cancer care. ERQCC papers give oncology teams, patients, policymakers and managers an overview of the elements needed in any healthcare system to provide high quality of care throughout the patient journey...
February 2017: Critical Reviews in Oncology/hematology
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