keyword
MENU ▼
Read by QxMD icon Read
search

Trypanosoma cruzi

keyword
https://www.readbyqxmd.com/read/29164071/galectin-3-a-friend-but-not-a-foe-during-trypanosoma-cruzi-experimental-infection
#1
Aline A da Silva, Thaise L Teixeira, Samuel C Teixeira, Fabrício C Machado, Marlus A Dos Santos, Tatiana C Tomiosso, Paula C B Tavares, Rebecca T E Silva Brígido, Flávia Alves Martins, Nadjania S de Lira Silva, Cassiano C Rodrigues, Maria C Roque-Barreira, Renato A Mortara, Daiana S Lopes, Veridiana de Melo Rodrigues Ávila, Claudio V da Silva
Trypanosoma cruzi interacts with host cells, including cardiomyocytes, and induces the production of cytokines, chemokines, metalloproteinases, and glycan-binding proteins. Among the glycan-binding proteins is Galectin-3 (Gal-3), which is upregulated after T. cruzi infection. Gal-3 is a member of the lectin family with affinity for β-galactose containing molecules; it can be found in both the nucleus and the cytoplasm and can be either membrane-associated or secreted. This lectin is involved in several immunoregulatory and parasite infection process...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29163920/harnessing-fungal-nonribosomal-cyclodepsipeptide-synthetases-for-mechanistic-insights-and-tailored-engineering
#2
Charlotte Steiniger, Sylvester Hoffmann, Andi Mainz, Marcel Kaiser, Kerstin Voigt, Vera Meyer, Roderich D Süssmuth
Nonribosomal peptide synthetases represent potential platforms for the design and engineering of structurally complex peptides. While previous focus has been centred mainly on bacterial systems, fungal synthetases assembling drugs like the antifungal echinocandins, the antibacterial cephalosporins or the anthelmintic cyclodepsipeptide (CDP) PF1022 await in-depth exploitation. As various mechanistic features of fungal CDP biosynthesis are only partly understood, effective engineering of NRPSs has been severely hampered...
November 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29162358/heart-transplantation-for-chagas-cardiomyopathy
#3
Ana Rita Ramalho, David Prieto, Fátima Franco, Manuel J Antunes
Chagas disease is an endemic disease in Latin America that is increasingly found in non-endemic areas all over the world due to the flow of migrants from Central and South America. We present the case of a Brazilian immigrant in Portugal who underwent orthotopic heart transplantation for end-stage Chagas cardiomyopathy. Immunosuppressive therapy included prednisone, mycophenolate mofetil and tacrolimus. Twelve months after the procedure she is asymptomatic, with good graft function, and with no evidence of complications such as graft rejection, opportunistic infections, neoplasms or reactivation of Trypanosoma cruzi infection...
November 18, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29162347/trypanosoma-cruzi-tryparedoxin-ii-interacts-with-different-peroxiredoxins-under-physiological-and-oxidative-stress-conditions
#4
L Dias, E F Peloso, A F P Leme, C M Carnielli, C N Pereira, C C Werneck, S Guerrero, F R Gadelha
Trypanosoma cruzi, the etiologic agent of Chagas disease, has to cope with reactive oxygen and nitrogen species during its life cycle in order to ensure its survival and infection. The parasite detoxifies these species through a series of pathways centered on trypanothione that depend on glutathione or low molecular mass dithiol proteins such as tryparedoxins. These proteins transfer reducing equivalents to peroxidases, including mitochondrial and cytosolic peroxiredoxins, TcMPx and TcCPx, respectively. In T...
November 18, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/29161488/identifying-trypanosoma-cruzi-discreet-typing-units-in-triatomines-collected-in-different-natural-regions-of-per%C3%A3%C2%BA
#5
Carlos P Padilla, Uriel Alvarado, Gladis Ventura, Deysi Luna-Caipo, Marcial Suárez, José R Tuñoque, Nancy Ruelas-Llerena, Luis A Fachín, Alina Huiza, Lizandro Gonzáles, Julio César Carranza, Gustavo Adolfo Vallejo, Gustavo Adolfo Vallejo, Abraham G Cáceres, Abraham G Cáceres
INTRODUCTION: Trypanosoma cruzi has been divided by international consensus into six discrete typing units (DTU): TcI, TcII, TcIII, TcIV, TcV y TcVI. The factors determining the dynamics of T. cruzi genotypes vector transmission of Chagas' disease in the different geographical regions of Perú are still unknown. OBJECTIVE: To detect and type T. cruzi DTUs from the faeces of seven species of triatomines (Panstrongylus chinai, P. geniculatus, P. herreri, Rhodnius robustus, R...
March 29, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29161480/-biological-parameters-of-meccus-phyllosomus-phyllosomus-burmeister-1835-triatoma-recurva-st%C3%A3-l-1868-hemiptera-reduviidae-and-their-laboratory-hybrids
#6
Lizbeth Díaz, Karen Covarrubias, Ángel Licón, Mixtli Astorga, Yaneth Moreno, José Alejandro Martínez
INTRODUCTION: Hybrids from species and subspecies of Mexican triatomines have shown outstanding biological and behavioral characteristics as compared with their parental groups. This could lead to an increasing risk of transmission of Trypanosoma cruzi to human and animal reservoir hosts. OBJECTIVE: To describe and compare biological parameters related to the life cycle of Triatoma recurva, Meccus phyllosomus phyllosomus and their laboratory hybrids and estimate their risk as transmitters of T...
March 29, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29160509/sympatry-influence-in-the-interaction-of-trypanosoma-cruzi-with-triatomine
#7
Elaine Schultz Dworak, Silvana Marques de Araújo, Mônica Lúcia Gomes, Miyoko Massago, Érika Cristina Ferreira, Max Jean de Ornelas Toledo
INTRODUCTION: Trypanosoma cruzi, the etiologic agent of Chagas disease, is widely distributed in nature, circulating between triatomine bugs and sylvatic mammals, and has large genetic diversity. Both the vector species and the genetic lineages of T. cruzi present a varied geographical distribution. This study aimed to verify the influence of sympatry in the interaction of T. cruzi with triatomines. Methods: The behavior of the strains PR2256 (T. cruzi II) and AM14 (T. cruzi IV) was studied in Triatoma sordida (TS) and Rhodnius robustus (RR)...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29158000/functional-genomic-fabrics-are-remodeled-in-a-mouse-model-of-chagasic-cardiomyopathy-and-restored-following-cell-therapy
#8
Dumitru A Iacobas, Sanda Iacobas, Herbert B Tanowitz, Antonio Campos de Carvalho, David C Spray
We previously found that, in a mouse model of Chagas cardiomyopathy (CCC), 18% of the 9390 quantified unigenes were significantly regulated by Trypanosoma cruzi infection. However, treatment with bone marrow-derived mononuclear cells (MNCs) resulted in 84% transcriptomic recovery. We have applied new algorithms to reanalyze these datasets with respect to specific pathways [CCC, cardiac muscle contraction (CMC) and chemokine signaling (CCS)]. In addition to the levels of expression of individual genes we also calculated gene expression variability and coordination of expression of each gene with all others...
November 17, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/29154947/16s-rrna-gene-amplicon-sequencing-reveals-dominance-of-actinobacteria-in-rhodnius-pallescens-compared-to-triatoma-maculata-midgut-microbiota-in-natural-populations-of-vector-insects-from-colombia
#9
Luisa M Montoya-Porras, Triana-Chavez Omar, F Alzate Juan, X Claudia Moreno Herrera, Gloria E Cadavid-Restrepo
Chagas disease affects more than 6 million people in Latin America, it is a parasitic disease caused by the protozoan Trypanosoma cruzi, which is transmitted mainly by bloodsucking insects of the Triatominae subfamily. Studies on microbial communities that inhabit the insect gut are important to understanding their role in the parasite transmission and development. The present work aims to evaluate the gut bacterial composition of natural populations of triatomine species from Vichada and Magdalena, administrative states called departments in Colombia, using high-throughput sequencing technologies...
November 15, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29147831/plants-of-brazilian-restingas-with-tripanocide-activity-against-trypanosoma-cruzi-strains
#10
Robson Xavier Faria, André Luis Almeida Souza, Barbara Lima, Luis Armando Candido Tietbohl, Caio Pinho Fernandes, Raquel Rodrigues Amaral, Bettina Monika Ruppelt, Marcelo Guerra Santos, Leandro Rocha
Chagas disease is caused by the Trypanosoma cruzi affecting millions of people, and widespread throughout Latin America. This disease exhibits a problematic chemotherapy. Benznidazole, which is the drug currently used as standard treatment, lamentably evokes several adverse reactions. Among other options, natural products have been tested to discover a novel therapeutic drug for this disease. A lot of plants from the Brazilian flora did not contain studies about their biological effects. Restinga de Jurubatiba from Brazil is a sandbank ecosystem poorly studied in relation to plant biological activity...
November 17, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29147578/modelling-historical-changes-in-the-force-of-infection-of-chagas-disease-to-inform-control-and-elimination-programmes-application-in-colombia
#11
Zulma M Cucunubá, Pierre Nouvellet, Lesong Conteh, Mauricio Javier Vera, Victor Manuel Angulo, Juan Carlos Dib, Gabriel Jaime Parra-Henao, María Gloria Basáñez
Background: WHO's 2020 milestones for Chagas disease include having all endemic Latin American countries certified with no intradomiciliary Trypanosoma cruzi transmission, and infected patients under care. Evaluating the variation in historical exposure to infection is crucial for assessing progress and for understanding the priorities to achieve these milestones. Methods: Focusing on Colombia, all the available age-structured serological surveys (undertaken between 1995 and 2014) were searched and compiled...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29145405/drivers-of-house-invasion-by-sylvatic-chagas-disease-vectors-in-the-amazon-cerrado-transition-a-multi-year-state-wide-assessment-of-municipality-aggregated-surveillance-data
#12
Raíssa N Brito, David E Gorla, Liléia Diotaiuti, Anália C F Gomes, Rita C M Souza, Fernando Abad-Franch
BACKGROUND: Insecticide spraying efficiently controls house infestation by triatomine bugs, the vectors of Trypanosoma cruzi. The strategy, however, is ineffective against sylvatic triatomines, which can transmit Chagas disease by invading (without colonizing) man-made structures. Despite growing awareness of the relevance of these transmission dynamics, the drivers of house invasion by sylvatic triatomines remain poorly understood. METHODS/FINDINGS: About 12,000 sylvatic triatomines were caught during routine surveillance in houses of Tocantins state, Brazil, in 2005-2013...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29144219/trypanosoma-sp-diversity-in-amazonian-bats-chiroptera-mammalia-from-acre-state-brazil
#13
Francisco C B Dos Santos, Cristiane V Lisboa, Samanta C C Xavier, Maria A Dario, Rair de S Verde, Armando M Calouro, André Luiz R Roque, Ana M Jansen
Bats are ancient hosts of Trypanosoma species and their flying ability, longevity and adaptability to distinct environments indicate that they are efficient dispersers of parasites. Bats from Acre state (Amazon Biome) were collected in four expeditions conducted in an urban forest (Parque Zoobotânico) and one relatively more preserved area (Seringal Cahoeira) in Rio Branco and Xapuri municipalities. Trypanosoma sp. infection was detected by hemoculture and fresh blood examination. Isolated parasite species were identified by the similarity of the obtained DNA sequence from 18S rDNA polymerase chain reaction and reference strains...
November 16, 2017: Parasitology
https://www.readbyqxmd.com/read/29141765/bionomics-and-spatial-distribution-of-triatomine-vectors-of-trypanosoma-cruzi-in-texas-and-other-southern-states-usa
#14
Rachel Curtis-Robles, Sarah A Hamer, Sage Lane, Michael Z Levy, Gabriel L Hamer
Defining spatial and temporal occurrences of triatomine vectors of Trypanosoma cruzi, the agent of Chagas disease, in the US is critical for public health protection. Through a citizen science program and field collections from 2012 to 2016, we collected 3,215 triatomines, mainly from Texas. Using morphological and molecular approaches, we identified seven Triatoma species and report sex, length, and blood engorgement status. Many citizen-collected triatomines (92.9%) were encountered indoors, in peridomestic settings, or in dog kennels and represent spillover transmission risk of T...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29141748/trypanosoma-cruzi-infection-induces-pannexin-1-channel-opening-in-cardiac-myocytes
#15
Iván Barría, Juan Güiza, Fredi Cifuentes, Pedro Zamorano, Juan C Sáez, Jorge González, José L Vega
Trypanosoma cruzi, the etiological agent of Chagas diseases, invades the cardiac tissue causing acute myocarditis and heart electrical disturbances. In T. cruzi invasion, the parasite induces [Ca(2+)]i transients in the host cells, an essential phenomenon for invasion. To date, knowledge on the mechanism that elicits transients of [Ca(2+)]i during the infection of cardiac myocytes has not been fully characterized. Pannexin1 (Panx1) channel are poorly selective channels found in all vertebrates that serve as a pathway for ATP release...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29140309/biosensors-to-diagnose-chagas-disease-a-brief-review
#16
REVIEW
María-Isabel Rocha-Gaso, Luis-Jesús Villarreal-Gómez, Denis Beyssen, Frédéric Sarry, Marco-Antonio Reyna, Carlos-Napoleón Ibarra-Cerdeña
Chagas disease (CD), which mostly affects those living in deprived areas, has become one of Latin America's main public health problems. Effective prevention of the disease requires early diagnosis, initiation of therapy, and regular blood monitoring of the infected individual. However, the majority of the Trypanosoma cruzi infections go undiagnosed because of mild symptoms, limited access to medical attention and to a high variability in the sensitivity and specificity of diagnostic tests. Consequently, more affordable and accessible detection technologies capable of providing early diagnosis and T...
November 15, 2017: Sensors
https://www.readbyqxmd.com/read/29140234/prevalence-of-trypanosoma-cruzi-and-other-trypanosomatids-in-frequently-hunted-wild-mammals-from-the-peruvian-amazon
#17
E Angelo Morales, Pedro Mayor, Mark Bowler, Esar Aysanoa, Erika S Pérez-Velez, Jocelyn Pérez, Julio A Ventocilla, G Christian Baldeviano, Andrés G Lescano
To better understand the ecology of Trypanosoma cruzi in the northeastern Peruvian Amazon, we evaluated the prevalence of T. cruzi and other trypanosomatids in four orders of wild mammals hunted and consumed by inhabitants of three remote indigenous communities in the Peruvian Amazon. Of 300 wild mammals sampled, 115 (38.3%) were infected with trypanosomatids and 15 (5.0%) with T. cruzi. The prevalence of T. cruzi within each species was as follows: large rodents (Cuniculus paca, 5.5%; Dasyprocta spp., 2.6%), edentates (Dasypus novemcinctus, 4...
November 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29133150/structure-and-function-of-per-arnt-sim-domains-and-their-possible-role-in-the-life-cycle-biology-of-trypanosoma-cruzi
#18
REVIEW
Maura Rojas-Pirela, Daniel J Rigden, Paul A Michels, Ana J Cáceres, Juan Luis Concepción, Wilfredo Quiñones
Per-ARNT-Sim (PAS) domains of proteins play important roles as modules for signalling and cellular regulation processes in widely diverse organisms such as Archaea, Bacteria, protists, plants, yeasts, insects and vertebrates. These domains are present in many proteins where they are used as sensors of stimuli and modules for protein interactions. Characteristically, they can bind a broad spectrum of molecules. Such binding causes the domain to trigger a specific cellular response or to make the protein containing the domain susceptible to responding to additional physical or chemical signals...
November 10, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/29132413/germacranolide-type-sesquiterpene-lactones-from-smallanthus-sonchifolius-with-promising-activity-against-leishmania-mexicana-and-trypanosoma-cruzi
#19
Jerónimo L Ulloa, Renata Spina, Agustina Casasco, Patricia B Petray, Virginia Martino, Miguel A Sosa, Fernanda M Frank, Liliana V Muschietti
BACKGROUND: Leishmaniasis and Chagas disease are life-threatening illnesses caused by the protozoan parasites Leishmania spp. and Trypanosoma cruzi, respectively. They are known as "neglected diseases" due to the lack of effective drug treatments and the scarcity of research work devoted to them. Therefore, the development of novel and effective drugs is an important and urgent need. Natural products are an important source of bioactive molecules for the development of new drugs. In this study, we evaluated the activity of enhydrin, uvedalin and polymatin B, three sesquiterpene lactones (STLs) isolated from Smallanthus sonchifolius, on Leishmania mexicana (MNYC/BZ/62/M) and Trypanosoma cruzi (Dm28c)...
November 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29128607/effects-of-a-new-antiprotozoal-drug-n-n-diphenyl-4-methoxy-benzamidine-on-energy-linked-functions-of-rat-liver-mitochondria
#20
Lyvia Lintzmaier Petiz, Amanda do Rocio Andrade Pires, Aurea Echevarria, Cláudio Eduardo Rodrigues-Santos, Maria Eliane Merlin Rocha, Alexandra Acco, Silvia Maria Suter Correia Cadena
Amidines are chemically characterized by the presence of two nitrogen atoms that bind to the same carbon atom in its structure. Several biological activities have been ascribed to these compounds. Pentamidine, an aromatic diamidine, is effective in the treatment against Pneumocystis carinii and leishmaniasis, but it can also have severe side effects. New amidine derivatives have been synthesized, among them N,N'-diphenyl-4-methoxy-benzamidine (methoxyamidine), which is effective against Leishmania amazonensis (LD50 = 20 μM) and Trypanosoma cruzi (LD50 = 59 nM)...
November 9, 2017: Chemico-biological Interactions
keyword
keyword
18221
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"