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Trypanosoma cruzi

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https://www.readbyqxmd.com/read/28919885/trypanosoma-cruzi-evades-the-complement-system-as-an-efficient-strategy-to-survive-in-the-mammalian-host-the-specific-roles-of-host-parasite-molecules-and-trypanosoma-cruzi-calreticulin
#1
REVIEW
Galia Ramírez-Toloza, Arturo Ferreira
American Trypanosomiasis is an important neglected reemerging tropical parasitism, infecting about 8 million people worldwide. Its agent, Trypanosoma cruzi, exhibits multiple mechanisms to evade the host immune response and infect host cells. An important immune evasion strategy of T. cruzi infective stages is its capacity to inhibit the complement system activation on the parasite surface, avoiding opsonizing, immune stimulating and lytic effects. Epimastigotes, the non-infective form of the parasite, present in triatomine arthropod vectors, are highly susceptible to complement-mediated lysis while trypomastigotes, the infective form, present in host bloodstream, are resistant...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28917755/identification-of-trypanosomatids-by-detecting-single-nucleotide-fingerprints-using-dna-analysis-by-dynamic-chemistry-with-maldi-tof
#2
María Angélica Luque-González, Mavys Tabraue-Chávez, Bárbara López-Longarela, Rosario María Sánchez-Martín, Matilde Ortiz-González, Miguel Soriano-Rodríguez, José Antonio García-Salcedo, Salvatore Pernagallo, Juan José Díaz-Mochón
Protozoan parasites of the Trypanosomatidae family can cause devastating diseases in humans and animals, such as Human African Trypanosomiasis or Sleeping Sickness, Chagas disease and Leishmaniasis. Currently, there are molecular assays for detecting parasitic infections and their post-treatment monitoring based on nucleic acid amplification, but there are still certain limitations which limit the development of assays that can detect and discriminate between parasite infections with a single test. Here, we present the development of a novel molecular assay for the rapid identification of Trypanosomatids, integrating DNA analysis by dynamic chemistry in conjunction with Matrix-Assisted Laser Desorption Ionization - Time-of-Flight Mass Spectrometry (MALDI-ToF)...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28912986/transmission-of-donor-derived-trypanosoma-cruzi-and-subsequent-development-of-chagas-disease-in-a-lung-transplant-recipient
#3
A B Corey, D Sonetti, J D Maloney, S P Montgomery, B L Rademacher, L J Taylor, J A Smith, R Striker
Donor infection status should be considered when accepting an organ for transplant. Here we present a case of Chagas disease developing after a lung transplant where the donor was known to be Trypanosoma cruzi antibody positive. The recipient developed acute Trypanosoma cruzi infection with reactivation after treatment. Chagas disease-positive donors are likely to be encountered in the United States; donor targeted screening is needed to guide decisions regarding organ transplant and posttransplant monitoring...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28912906/constipation-is-related-to-small-bowel-disturbance-rather-than-colonic-enlargement-in-acquired-chagasic-megacolon
#4
Mauro Bafutto, Alejandro Ostermayer Luquetti, Salustiano Gabriel Neto, Felix Andre Sanches Penhavel, Enio Chaves Oliveira
BACKGROUND: Constipation is the main symptom of acquired chagasic megacolon. However, a number of patients with Chagas disease without colon involvement also have the same complain. This study evaluated the role of small bowel in constipated patients with Chagas disease with and without megacolon. METHODS: Orocecal transit time (OCTT) and oral glucose tolerance test (OGTT) in constipated non-chagasic and chagasic patients with and without megacolon were performed...
August 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28911515/chronic-chagas-heart-disease%C3%A2-management-from-etiology-to-cardiomyopathy-treatment
#5
REVIEW
Edimar Alcides Bocchi, Reinaldo Bulgarelli Bestetti, Mauricio Ibrahim Scanavacca, Edecio Cunha Neto, Victor Sarli Issa
Trypanosoma cruzi (T. cruzi) infection is endemic in Latin America and is becoming a worldwide health burden. It may lead to heterogeneous phenotypes. Early diagnosis of T. cruzi infection is crucial. Several biomarkers have been reported in Chagas heart disease (ChHD), but most are nonspecific for T. cruzi infection. Prognosis of ChHD patients is worse compared with other etiologies, with sudden cardiac death as an important mode of death. Most ChHD patients display diffuse myocarditis with fibrosis and hypertrophy...
September 19, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28910663/strategies-for-overcoming-tropical-disease-by-ruthenium-complexes-with-purine-analog-application-against-leishmania-spp-and-trypanosoma-cruzi
#6
Marzena Fandzloch, José Manuel Méndez Arriaga, Manuel Sánchez-Moreno, Andrzej Wojtczak, Julia Jezierska, Jerzy Sitkowski, Joanna Wiśniewska, Juan Manuel Salas, Iwona Łakomska
Tropical diseases currently constitute a major health problem and thus a challenge in the field of drug discovery. The current treatments show serious disadvantages due to cost, toxicity, long therapy duration and resistance, and the use of metal complexes as chemotherapeutic agents against these ailments appears to be a very attractive alternative. Herein, we describe three newly synthesized ruthenium complexes with a bioactive molecule, the purine analogue 5,6,7-trimethyl-1,2,4-triazolo[1,5-a]pyrimidine (tmtp): cis,fac-[RuCl2(dmso)3(tmtp)] (1), mer-[RuCl3(dmso)(H2O)(tmtp)]·2H2O (2) and fac,cis-[RuCl3(H2O)(tmtp)2] (3)...
September 1, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28910299/access-to-benznidazole-for-chagas-disease-in-the-united-states-cautious-optimism
#7
Jonathan D Alpern, Rogelio Lopez-Velez, William M Stauffer
Drugs for neglected tropical diseases (NTD) are being excessively priced in the United States. Benznidazole, the first-line drug for Chagas disease, may become approved by the Food and Drug Administration (FDA) and manufactured by a private company in the US, thus placing it at risk of similar pricing. Chagas disease is an NTD caused by Trypanosoma cruzi; it is endemic to Latin America, infecting 8 million individuals. Human migration has changed the epidemiology causing nonendemic countries to face increased challenges in diagnosing and managing patients with Chagas disease...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28905716/lack-of-trypanosoma-cruzi-infection-in-urban-roof-rats-rattus-rattus-at-a-texas-facility-housing-naturally-infected-nonhuman-primates
#8
Carolyn L Hodo, Nicole R Bertolini, John C Bernal, John L VandeBerg, Sarah A Hamer
The protozoan parasite Trypanosoma cruzi causes Chagas disease, uses kissing bugs as a vector, and is maintained in nature by a variety of wildlife reservoirs. Many natural cases of Chagas disease have been reported in NHP at facilities across the southern United States, where infected vectors and wildlife occur. Infection of NHP with T. cruzi can diminish their value as research models and lead to health problems and death. Identifying the modes of transmission and role of wildlife reservoirs in these facilities is therefore critical to guide interventions to reduce transmission...
January 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28902285/dipyridamole-potentiated-the-trypanocidal-effect-of-nifurtimox-and-improved-the-cardiac-function-in-nmri-mice-with-acute-chagasic-myocarditis
#9
Sonia Santeliz, Peter Caicedo, Elidiosmar Giraldo, Carmen Alvarez, María-Daniela Yustiz, Claudina Rodríguez-Bonfante, Romina Bonfante-Rodríguez, Rafael Bonfante-Cabarcas
BACKGROUND: As chronic Chagas disease does not have a definitive treatment, the development of alternative therapeutic protocols is a priority. Dipyridamole (DPY) is an alternative to counteract the pathophysiological phenomena involved in Chagas cardiomyopathy. OBJECTIVE: To evaluate the therapeutic efficacy of DPY associated with nifurtimox (Nfx) in epimastigote axenic cultures and in mice with acute Chagas disease. METHODS: NMRI adult male mice were divided into nine groups: three healthy and six Trypanosoma cruzi-infected groups...
September 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28895840/crucial-role-for-t-cell-intrinsic-il-18r-myd88-signaling-in-cognate-immune-response-to-intracellular-parasite-infection
#10
Ana-Carolina Oliveira, João Francisco Gomes-Neto, Carlos-Henrique Dantas Barbosa, Alessandra Granato, Bernardo S Reis, Bruno Maia Santos, Rita Fucs, Fábio B Canto, Helder I Nakaya, Alberto Nóbrega, Maria Bellio
MyD88 is the main adaptor molecule for TLR and IL-1R family members. Here, we demonstrated that T-cell intrinsic MyD88 signaling is required for proliferation, protection from apoptosis and expression of activation/memory genes during infection with the intracellular parasite Trypanosoma cruzi, as evidenced by transcriptome and cytometry analyses in mixed bone-marrow (BM) chimeras. The lack of direct IL-18R signaling in T cells, but not of IL-1R, phenocopied the absence of the MyD88 pathway, indicating that IL-18R is a critical MyD88-upstream pathway involved in the establishment of the Th1 response against an in vivo infection, a presently controvert subject...
September 12, 2017: ELife
https://www.readbyqxmd.com/read/28892370/mass-spectrometry-based-chemical-cartography-of-a-cardiac-parasitic-infection
#11
Laura-Isobel McCall, James T Morton, Jean A Bernatchez, Jair L Siqueira-Neto, Rob Knight, Pieter C Dorrestein, James H McKerrow
Trypanosoma cruzi parasites are the causative agents of Chagas disease, a leading infectious form of heart failure whose pathogenesis is still not fully characterized. In this work, we applied untargeted liquid chromatography-tandem mass spectrometry to heart sections from T. cruzi-infected and uninfected mice. We combined molecular networking and 3-dimensional modeling to generate chemical cartographical heart models. This approach revealed for the first time preferential parasite localization to the base of the heart and regiospecific distributions of nucleoside derivatives and eicosanoids, which we correlated to tissue-damaging immune responses...
September 11, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28887895/impact-of-climate-change-on-vector-transmission-of-trypanosoma-cruzi-chagas-1909-in-north-america
#12
O Carmona-Castro, D A Moo-Llanes, J M Ramsey
Climate change can influence the geographical range of the ecological niche of pathogens by altering biotic interactions with vectors and reservoirs. The distributions of 20 epidemiologically important triatomine species in North America were modelled, comparing the genetic algorithm for rule-set prediction (GARP) and maximum entropy (MaxEnt), with or without topographical variables. Potential shifts in transmission niche for Trypanosoma cruzi (Trypanosomatida: Trypanosomatidae) (Chagas, 1909) were analysed for 2050 and 2070 in Representative Concentration Pathway (RCP) 4...
September 9, 2017: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/28887214/trypanocidal-activity-of-polysaccharide-extract-from-genipa-americana-leaves
#13
Racquel Oliveira da Silva Souza, Paloma Leão Sousa, Ramon Róseo Paula Pessoa Bezerra de Menezes, Tiago Lima Sampaio, Louise Donadello Tessarolo, Francisca Crislandia Oliveira Silva, Maria Gonçalves Pereira, Alice Maria Costa Martins
ETHNOPHARMACOLOGICAL RELEVANCE: The parts of the Genipa americana (Rubiaceae) tree, also known as "jenipapo" or "jenipapeiro", has been used in traditional Medicine in parasitic and bacterial infections. Thus, the experimental evolution of the antiparasitic activity of polysaccharide extracts from Genipa americana leaves, and correlation with antiparasitic and popular use is important. AIM OF THE STUDY: To evaluate the effect of polysaccharide extract obtained from Genipa americana leaves on all Trypanosoma cruzi (Y strain: benznidazole-resistant) developmental forms, a protozoan that causes Chagas' disease...
September 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28884498/aldo-keto-reductase-and-alcohol-dehydrogenase-contribute-to-benznidazole-natural-resistance-in-trypanosoma-cruzi
#14
Laura González, Paola García-Huertas, Omar Triana-Chávez, Gabriela Andrea García, Silvane Maria Fonseca Murta, Ana M Mejía-Jaramillo
The improvement of Chagas disease treatment is focused not only on the development of new drugs but also in understanding mechanisms of action and resistance to drugs conventionally used. Thus, some strategies aim to detect specific changes in proteins between sensitive and resistant parasites and to evaluate the role played in these processes by functional genomics. In this work, we used a natural Trypanosoma cruzi population resistant to benznidazole, which has clones with different susceptibilities to this drug without alterations in the NTR I gene...
September 7, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28881289/efficacy-of-a-series-of-alpha-pyrone-derivatives-against-leishmania-l-infantum-and-trypanosoma-cruzi
#15
Andre Gustavo Tempone, Daiane Dias Ferreira, Marta Lopes Lima, Thais Alves Costa Silva, Samanta E T Borborema, Juliana Quero Reimão, Mariana K Galuppo, Juliana Mariotti Guerra, Angelie J Russell, Graham M Wynne, Roy Y L Lai, Melissa M Cadelis, Brent R Copp
The neglected tropical diseases Chagas disease and leishmaniasis affect together more than 20 million people living mainly in developing countries. The mainstay of treatment is chemotherapy, however the drugs of choice, which include benznidazole and miltefosine, are toxic and have numerous side effects. Safe and effective therapies are urgently needed. Marine alpha-pyrones have been previously identified as scaffolds with potential antiprotozoan activities. In this work, using a phenotypic screen, twenty-seven examples of 3-substituted 4-hydroxy-6-methyl alpha-pyrones were synthesized and their antiparasitic efficacy evaluated against Leishmania (L...
September 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28877735/priming-astrocytes-with-tnf-enhances-their-susceptibility-to-trypanosoma-cruzi-infection-and-creates-a-self-sustaining-inflammatory-milieu
#16
Andrea Alice Silva, Rafael Rodrigues Silva, Daniel Gibaldi, Rafael Meyer Mariante, Jessica Brandão Dos Santos, Isabela Resende Pereira, Otacílio Cruz Moreira, Joseli Lannes-Vieira
BACKGROUND: In conditions of immunosuppression, the central nervous sty 5ystem (CNS) is the main target tissue for the reactivation of infection by Trypanosoma cruzi, the causative agent of Chagas disease. In experimental T. cruzi infection, interferon gamma (IFNγ)(+) microglial cells surround astrocytes harboring amastigote parasites. In vitro, IFNγ fuels astrocyte infection by T. cruzi, and IFNγ-stimulated infected astrocytes are implicated as potential sources of tumor necrosis factor (TNF)...
September 6, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28873423/an-immunosignature-test-distinguishes-trypanosoma-cruzi-hepatitis-b-hepatitis-c-and-west-nile-virus-seropositivity-among-asymptomatic-blood-donors
#17
Michael Rowe, Jonathan Melnick, Robert Gerwien, Joseph B Legutki, Jessica Pfeilsticker, Theodore M Tarasow, Kathryn F Sykes
BACKGROUND: The complexity of the eukaryotic parasite Trypanosoma (T.) cruzi manifests in its highly dynamic genome, multi-host life cycle, progressive morphologies and immune-evasion mechanisms. Accurate determination of infection or Chagas' disease activity and prognosis continues to challenge researchers. We hypothesized that a diagnostic platform with higher ligand complexity than previously employed may hold value. METHODOLOGY: We applied the ImmunoSignature Technology (IST) for the detection of T...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28870526/drug-repurposing-strategy-against-trypanosoma-cruzi-infection-in-vitro-and-in-vivo-assessment-of-the-activity-of-metronidazole-in-mono-and-combined-therapy
#18
M R Simões-Silva, J S De Araújo, G M Oliveira, K C Demarque, R B Peres, I D'Almeida-Melo, D G J Batista, C F Da Silva, C Cardoso-Santos, P B Da Silva, M M Batista, M T Bahia, M N C Soeiro
Metronidazole (Mtz) is a commercial broad-spectrum nitroimidazolic derivative with relevant antimicrobial activity and relative safety profile. Therefore, it is fair to consider Mtz a candidate for drug repurposing for other neglected conditions such as Chagas disease (CD), a parasitic pathology caused by Trypanosoma cruzi. CD is treated only with benznidazole (Bz) and nifurtimox, both introduced in clinics decades ago despite important limitations, including low efficacy on the later disease stage (chronic form) and severe side effects...
September 1, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28870247/seropositivity-for-trypanosoma-cruzi-in-domestic-dogs-from-sonora-mexico
#19
Minerva Arce-Fonseca, Silvia C Carrillo-Sánchez, Ramón M Molina-Barrios, Mariana Martínez-Cruz, Jesús R Cedillo-Cobián, Yuly A Henao-Díaz, Olivia Rodríguez-Morales
BACKGROUND: Chagas disease is an important health problem in Latin America due to its incapacitating effects and associated mortality. Studies on seropositivity for Trypanosoma cruzi in Mexican dogs have demonstrated a direct correlation between seropositivity in humans and dogs, which can act as sentinels for the disease in this region. The objective of this study was to determine the seropositivity for T.cruzi infection in dogs from Sonora, a northern borderstate of Mexico. METHODS: Responsible pet owners were selected at random from an urban area of Empalme municipality, Sonora, Mexico, and from there, 180 dog samples were collected...
September 5, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28869694/strongyloides-stercoralis-infection-increases-the-likelihood-to-detect-trypanosoma-cruzi-dna-in-peripheral-blood-in-chagas-disease-patients
#20
Fernando Salvador, Elena Sulleiro, Maria Piron, Adrián Sánchez-Montalvá, Silvia Sauleda, Daniel Molina-Morant, Zaira Moure, Israel Molina
OBJECTIVES: In a previous study performed by our group, S. stercoralis infection in Chagas disease patients was associated with higher proportion of Trypanosoma cruzi DNA detection in peripheral blood. The aim of the study was to confirm this association in a larger cohort of patients. METHODS: Cross-sectional study of all Chagas disease patients diagnosed from 2005 to 2015 during blood donation at the Catalan Blood Bank. Demographic data and T. cruzi RT-PCR were collected...
September 4, 2017: Tropical Medicine & International Health: TM & IH
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