keyword
MENU ▼
Read by QxMD icon Read
search

Trypanosoma cruzi

keyword
https://www.readbyqxmd.com/read/28449112/phenotypic-variability-of-the-amazonian-species-rhodnius-brethesi-hemiptera-reduviidae
#1
A C Souza, S Catalá, A L Carbajal de la Fuente, A C V Junqueira
The wild species Rhodnius brethesi (Matta, 1919) (Hemiptera: Reduviidae) is found in areas of piassabais in microregion of Rio Negro, Amazonas, Brazil. Its geographical distribution overlaps the areas of Leopoldinia piassaba palm. In areas where palm trees are found, transmission cycle of Trypanosoma cruzi is related to the extractive activity of the palm fiber, exposing workers to wild vector transmission of this parasite. The close association with the palm tree L. piassaba suggests that this wild triatomine has special features in its sensory system allowing specificity of ecotope...
April 25, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28443980/chagas-disease-national-survey-of-seroprevalence-in-children-under-five-years-of-age-conducted-in-2008
#2
Graciela Russomando, Blanca Cousiño, Zunilda Sanchez, Laura X Franco, Eva M Nara, Lilian Chena, Magaly Martínez, María E Galeano, Lucio Benitez
BACKGROUND: Since the early 1990s, programs to control Chagas disease in South America have focused on eradicating domiciliary Triatoma infestans, the main vector. Seroprevalence studies of the chagasic infection are included as part of the vector control programs; they are essential to assess the impact of vector control measures and to monitor the prevention of vector transmission. OBJECTIVE: To assess the interruption of domiciliary vector transmission of Chagas disease by T...
May 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28442446/proteomic-and-transcriptomic-analysis-of-saliva-components-from-the-hematophagous-reduviid-triatoma-pallidipennis
#3
María J Hernández-Vargas, Jeovanis Gil, Luis Lozano, Martha Pedraza-Escalona, Ernesto Ortiz, Sergio Encarnación-Guevara, Alejandro Alagón, Gerardo Corzo
Species belonging to the Triatominae subfamily are commonly associated with Chagas disease, as they are potential vectors of the parasite Trypanosoma cruzi. However, their saliva contains a cocktail of diverse anti-hemostatic proteins that prevent blood coagulation, vasodilation and platelet aggregation of blood; components with indisputable therapeutic potential. We performed a transcriptomic and proteomic analyses of salivary glands and protein spots from 2DE gels of milked saliva, respectively, from the Mexican Triatoma pallidipennis...
April 22, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28439451/automated-identification-of-insect-vectors-of-chagas-disease-in-brazil-and-mexico-the-virtual-vector-lab
#4
Rodrigo Gurgel-Gonçalves, Ed Komp, Lindsay P Campbell, Ali Khalighifar, Jarrett Mellenbruch, Vagner José Mendonça, Hannah L Owens, Keynes de la Cruz Felix, A Townsend Peterson, Janine M Ramsey
Identification of arthropods important in disease transmission is a crucial, yet difficult, task that can demand considerable training and experience. An important case in point is that of the 150+ species of Triatominae, vectors of Trypanosoma cruzi, causative agent of Chagas disease across the Americas. We present a fully automated system that is able to identify triatomine bugs from Mexico and Brazil with an accuracy consistently above 80%, and with considerable potential for further improvement. The system processes digital photographs from a photo apparatus into landmarks, and uses ratios of measurements among those landmarks, as well as (in a preliminary exploration) two measurements that approximate aspects of coloration, as the basis for classification...
2017: PeerJ
https://www.readbyqxmd.com/read/28435310/tropical-diseases-of-the-myocardium-a-review
#5
REVIEW
Zoe C Groom, Aristotle D Protopapas, Vasileios Zochios
Cardiovascular diseases are widely distributed throughout the world. Human parasitic infections are ubiquitous. Tropical parasites are increasingly recognized as causes of cardiovascular diseases. In this review, we address the most frequently reported parasites that directly infect the myocardium, including Trypanosoma cruzi, the protozoal causative agent of American trypanosomiasis (Chagas disease), and Taenia solium, the cestode causative agent of taeniasis and cysticercosis. We also discuss tropical endomyocardial fibrosis, trichinellosis and schistosomiasis...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/28435221/phenotypic-evaluation-and-in-silico-admet-properties-of-novel-arylimidamides-in-acute-mouse-models-of-trypanosoma-cruzi-infection
#6
Cristiane França da Silva, Denise da Gama Jaén Batista, Julianna Siciliano de Araújo, Edézio Ferreira Cunha-Junior, Chad E Stephens, Moloy Banerjee, Abdelbasset A Farahat, Senol Akay, Mary K Fisher, David W Boykin, Maria de Nazaré Correia Soeiro
Arylimidamides (AIAs), previously termed as reversed amidines, present a broad spectrum of activity against intracellular microorganisms. In the present study, three novel AIAs were evaluated in a mouse model of Trypanosoma cruzi infection, which is the causative agent of Chagas disease. The bis-AIAs DB1957, DB1959 and DB1890 were chosen based on a previous screening of their scaffolds that revealed a very promising trypanocidal effect at nanomolar range against both the bloodstream trypomastigotes (BTs) and the intracellular forms of the parasite...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28432816/rhodnius-prolixus-from-classical-physiology-to-modern-developmental-biology
#7
REVIEW
Rodrigo Nunes-da-Fonseca, Mateus Berni, Vitória Tobias-Dos-Santos, Attilio Pane, Helena Marcolla Araujo
The hemiptera Rhodnius prolixus is a blood-feeding insect and a primary vector of Trypanosoma cruzi, the etiological agent of the Chagas disease. Over the past century, Rhodnius has been the subject of intense investigations, which have contributed to unveil important aspects of metabolism and physiology in insects. Recent technological innovations are helping dissect the genetic and molecular underpinnings of Rhodnius embryogenesis and organogenesis, thus fostering the use of this important species in the fields of developmental and evolutionary biology...
April 22, 2017: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/28427957/pcr-based-identification-of-trypanosoma-lewisi-and-trypanosoma-musculi-using-maxicircle-kinetoplast-dna
#8
Xiao-Kun Hong, Xuan Zhang, Octavio Alejandro Fusco, You-Gen Lan, Zhao-Rong Lun, De-Hua Lai
Trypanosoma lewisi, transmitted by rat fleas, is a widespread pathogen specific to rats with records of human infection cases. Its closely related species with global distribution, Trypanosoma musculi, is transmitted between mice by ingestion of infected fleas. These trypanosomes are of similar morphology, making it difficult to distinguish them by microscopy. In this study, we have developed a rapid, sensitive and reliable PCR method for the diagnosis of T. lewisi and T. musculi. The T. lewisi-specific amplicons were not produced by other Trypanosoma, such as T...
April 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28421410/antiparasitic-sesquiterpenes-from-the-cameroonian-spice-scleria-striatinux-and-preliminary-in-vitro-and-in-silico-dmpk-assessment
#9
Kennedy D Nyongbela, Fidele Ntie-Kang, Thomas R Hoye, Simon M N Efange
The antiparasitic activity and preliminary in vitro and in silico drug metabolism and pharmacokinetic (DMPK) assessment of six isomeric sesquiterpenes (1-6), isolated from the Cameroonian spice Scleria striatinux De Wild (Cyperaceae) is reported. The study was prompted by the observation that two of the compounds (1 and 2) exhibited varying levels of antiparasitic activity on Plasmodium falciparum, Trypanosoma brucei rhodesiense, Trypanosoma cruzi and Leishmania donovani. The in silico method employed a total of 46 descriptors, calculated using Schrödinger QikProp software...
April 18, 2017: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/28419477/the-effectiveness-of-riboflavin-and-ultraviolet-light-pathogen-reduction-technology-in-eliminating-trypanosoma-cruzi-from-leukoreduced-whole-blood
#10
Teresa Jimenez-Marco, Beatriz Cancino-Faure, Enrique Girona-Llobera, M Magdalena Alcover, Cristina Riera, Roser Fisa
BACKGROUND: The parasitic Chagas disease is caused by the protozoan Trypanosoma cruzi, which is mainly transmitted by insect vectors. Other infection routes, both in endemic and in nonendemic areas, include organ and marrow transplantation, congenital transmission, and blood transfusion. Asymptomatic chronic chagasic individuals may have a low and transient parasitemia in peripheral blood and, consequently, they can unknowingly transmit the disease via blood transfusion. Riboflavin and ultraviolet (UV) light pathogen reduction is a method to reduce pathogen transfusion transmission risk based on damage to the pathogen nucleic acids...
April 16, 2017: Transfusion
https://www.readbyqxmd.com/read/28414672/a-strong-and-fortuitous-case-of-dyspnea
#11
R Hammer, M Sciaudone
CASE: A 48 year-old man with no past medical history was sent to our emergency department (ED); from a primary care clinic for hypertensive urgency of 200/130. The man reported an intermittent non-productive cough of approximately one year's duration and worsening dyspnea on exertion and orthopnea over the last month with lower extremity swelling. Of note, he emigrated from Honduras twenty years ago. Blood pressure normalized with administration of Lasix in the ED. Physical exam revealed rales in lung bases bilaterally, jugular venous distension, lower extremity pitting edema with serpiginous patches of erythema and excoriation, and a cardiac gallop...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28413725/trypanosoma-cruzi-reservoir-triatomine-vector-co-occurrence-networks-reveal-meta-community-effects-by-synanthropic-mammals-on-geographic-dispersal
#12
Carlos N Ibarra-Cerdeña, Leopoldo Valiente-Banuet, Víctor Sánchez-Cordero, Christopher R Stephens, Janine M Ramsey
Contemporary patterns of land use and global climate change are modifying regional pools of parasite host species. The impact of host community changes on human disease risk, however, is difficult to assess due to a lack of information about zoonotic parasite host assemblages. We have used a recently developed method to infer parasite-host interactions for Chagas Disease (CD) from vector-host co-occurrence networks. Vector-host networks were constructed to analyze topological characteristics of the network and ecological traits of species' nodes, which could provide information regarding parasite regional dispersal in Mexico...
2017: PeerJ
https://www.readbyqxmd.com/read/28411096/-seroprevalence-and-vertical-transmission-of-chagas-disease-in-a-cohort-of-latin-american-pregnant-women-in-a-tertiary-hospital-in-madrid
#13
Laura Francisco-González, Teresa Gastañaga-Holguera, Beatriz Jiménez Montero, Zarife Daoud Pérez, Marta Illán Ramos, Paloma Merino Amador, Miguel Ángel Herráiz Martínez, José Tomás Ramos Amador
BACKGROUND: Chagas disease, caused by Trypanosoma cruzi (T. cruzi), is endemic in Latin-America and is emerging in Spain due to immigration. The vertical transmission rate is around 5%. A routine prenatal screening with serology of all pregnant women from endemic areas is recommended to identify infected newborns, allowing early treatment and cure. OBJECTIVE: The aim of this study was to estimate the prevalence of positive Chagas serology in a cohort of pregnant women from Latin-America and its vertical transmission...
April 12, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28406967/differential-transcriptome-analysis-supports-rhodnius-montenegrensis-and-rhodnius-robustus-hemiptera-reduviidae-triatominae-as-distinct-species
#14
Danila Blanco de Carvalho, Carlos Congrains, Samira Chahad-Ehlers, Heloisa Pinotti, Reinaldo Alves de Brito, João Aristeu da Rosa
Chagas disease is one of the main parasitic diseases found in Latin America and it is estimated that between six and seven million people are infected worldwide. Its etiologic agent, the protozoan Trypanosoma cruzi, is transmitted by triatomines, some of which from the genus Rhodnius. Twenty species are currently recognized in this genus, including some closely related species with low levels of morphological differentiation, such as Rhodnius montenegrensis and Rhodnius robustus. In order to investigate genetic differences between these two species, we generated large-scale RNA-sequencing data (consisting of four RNA-seq libraries) from the heads and salivary glands of males of R...
2017: PloS One
https://www.readbyqxmd.com/read/28406895/the-superfamily-keeps-growing-identification-in-trypanosomatids-of-ribj-the-first-riboflavin-transporter-family-in-protists
#15
Darío E Balcazar, María Cristina Vanrell, Patricia S Romano, Claudio A Pereira, Fernando A Goldbaum, Hernán R Bonomi, Carolina Carrillo
BACKGROUND: Trypanosomatid parasites represent a major health issue affecting hundreds of million people worldwide, with clinical treatments that are partially effective and/or very toxic. They are responsible for serious human and plant diseases including Trypanosoma cruzi (Chagas disease), Trypanosoma brucei (Sleeping sickness), Leishmania spp. (Leishmaniasis), and Phytomonas spp. (phytoparasites). Both, animals and trypanosomatids lack the biosynthetic riboflavin (vitamin B2) pathway, the vital precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) cofactors...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28399301/wing-polymorphism-and-trypanosoma-cruzi-infection-in-wild-peridomestic-and-domestic-collections-of-mepraia-spinolai-hemiptera-reduviidae-from-chile
#16
Daniel Frías-Lasserre, Christian R González, Carolina Reyes Valenzuela, Danila Blanco de Carvalho, Jader Oliveira, Mauricio Canals, Joao Aristeu da Rosa
Mepraia spinolai (Porter) is a vector of Trypanosoma cruzi that causes Chagas disease. Females are always wingless, but males may be winged or wingless. We determined by PCR the infection percentage with T. cruzi of M. spinolai adults and nymphs in domestic, peridomestic, and wild collections, in different regions of Chile. In all regions, winged males were more abundant than females and wingless males. Winged males collected inside houses were less parasitized than were those from peridomestic and wild environments...
March 24, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28399226/biology-of-triatoma-sherlocki-hemiptera-reduviidae-under-laboratory-conditions-biological-cycle-and-resistance-to-starvation
#17
Vanessa Lima-Neiva, Teresa C M Gonçalves, Leonardo S Bastos, Marcia Gumiel, Nathália C Correia, Catia C Silva, Carlos E Almeida, Jane Costa
Triatoma sherlocki Papa, Jurberg, Carcavallo, Cerqueira & Barata was described in 2002, based on specimens caught in the wild in the municipality of Gentio do Ouro, Bahia, Brazil. In 2009, nymphs and adults were detected inside homes and sylvatic specimens were positive for Trypanosoma cruzi (Chagas). No information on the bionomics of T. sherlocki exists, although such data are considered essential to estimate its vector and colonization potential in domestic environments. Herein, the biological cycle of T...
March 30, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28398292/the-contemporary-distribution-of-trypanosoma-cruzi-infection-in-humans-alternative-hosts-and-vectors
#18
Annie J Browne, Carlos A Guerra, Renato Vieira Alves, Veruska Maia da Costa, Anne L Wilson, David M Pigott, Simon I Hay, Steve W Lindsay, Nick Golding, Catherine L Moyes
Chagas is a potentially fatal chronic disease affecting large numbers of people across the Americas and exported throughout the world through human population movement. It is caused by the Trypanosoma cruzi parasite, which is transmitted by triatomine vectors to humans and a wide range of alternative host species. The database described here was compiled to allow the risk of vectorial transmission to humans to be mapped using geospatial models. The database collates all available records, published since 2003, for prevalence and occurrence of infection in humans, vectors and alternative hosts, and links each record to a defined time and location...
April 11, 2017: Scientific Data
https://www.readbyqxmd.com/read/28394985/-chagas-disease-affecting-the-central-nervous-system-in-a-patient-with-aids-demonstrated-by-quantitative-molecular-methods
#19
Alberto Fica, Marcia Salinas, María Isabel Jercic, Jeannette Dabanch, Andrés Soto, Sergio Quintanilla, Carlos Flores
Although infrequent, Trypanosoma cruzi reactivation is possible among patients with HIV/AIDS infection that develop a tumor-like or granulomatous lesion in the CNS. We report the case of a 60 years old male patient with HIV/AIDS and low CD4 lymphocytes count with cerebellar symptoms and mild paresis, associated to supra and infratentorial hypodense lesions and positive serology tests both to T. gondii and Trypanosoma cruzi. Empirical therapy against toxoplasmosis was prescribed together with antiretroviral therapy but without a favorable response...
February 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28394983/-chagas-disease-in-the-central-nervous-system-in-patient-infected-with-hiv-diagnostic-and-therapeutic-difficulties
#20
Federico Simioli, Milagro Sánchez-Cunto, Elsa Velázquez, Susana Lloveras, Tomás Orduna
Chagas disease (ChD), caused by the protozoan Trypanosoma cruzi, is an endemic anthropozoonosis in Latin America, linked to deficients socio-economic and cultural aspects and is considered one of the neglected tropical diseases. We report a fatal case of Chagas disease reactivation with central nervous system involvement in a patient with HIV infection, whose diagnosis was confirmed by positive PCR (polymerase chain reaction) test of blood, with treatment response efficiency with benznidazol and management and etiologic treatment was difficult due to limited number of antitrypanosomal drugs and the occurrence of frequent and serious adverse effects...
February 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
keyword
keyword
18221
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"