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Trypanosoma cruzi

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https://www.readbyqxmd.com/read/28532988/molecular-and-serological-detection-of-trypanosoma-cruzi-in-dogs-canis-lupus-familiaris-suggests-potential-transmission-risk-in-areas-of-recent-acute-chagas-disease-outbreaks-in-colombia
#1
Jeiczon Jaimes-Dueñez, Omar Triana-Chávez, Omar Cantillo-Barraza, Carolina Hernández, Juan David Ramírez, Agustín Góngora-Orjuela
Chagas disease is a zoonotic infection widely distributed in tropical and subtropical regions of America, including more than 50% of the Colombian territory. In the last years, an increase of outbreaks of acute Chagas disease has been observed in the east of the country due to environmental changes and mammal movements toward human settlements. Given the importance of dogs (Canis lupus familiaris) as reservoir hosts and sentinels of Trypanosoma cruzi infection across different regions of America, in this study we reported a serological and molecular detection of T...
June 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28531996/poly-epsilon-caprolactone-nanoparticles-enhance-ursolic-acid-in-vivo-efficacy-against-trypanosoma-cruzi-infection
#2
Juliana Palma Abriata, Josimar O Eloy, Thalita Bachelli Riul, Patricia Mazureki Campos, Marcelo Dias Baruffi, Juliana Maldonado Marchetti
Despite affecting millions of people worldwide, Chagas disease is still neglected by the academia and industry and the therapeutic option available, benznidazole, presents limited efficacy and side effects. Within this context, ursolic acid may serve as an option for treatment, however has low bioavailability, which can be enhanced through the encapsulation in polymeric nanoparticles. Therefore, herein we developed ursolic acid-loaded nanoparticles with poly-ε-caprolactone by the nanoprecipitation method and characterized them for particle size, zeta potential, polydispersity, encapsulation efficiency, morphology by scanning electron microscopy and thermal behavior by differential scanning calorimetry...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28530845/temporal-variation-in-the-abundance-and-timing-of-daily-activity-of-chagas-disease-vector-triatoma-gerstaeckeri-st%C3%A3-l-1859-in-a-natural-habitat-in-the-lower-rio-grande-valley-south-texas
#3
Alfredo Flores, Christopher Vitek, Teresa Feria Arroyo, Brian Lund Fredensborg
Chagas disease caused by Trypanosoma cruzi is a burden to millions of people in South and Central America. A sylvatic life cycle of the parasite exists in the Southern United States, but recent studies indicate an active peri-domestic life cycle of T. cruzi in Texas. The USA-Mexico border region in Texas displays areas of high poverty and sub-standard housing conditions which are important risk factors for a potential spill-over transmission to a domestic life cycle including humans. The objectives of the study were to examine short- and longterm temporal variation in vector activity, and to evaluate the effect of different combinations of attractants on the capture of potential triatomine vectors...
May 22, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28527905/peroxisome-proliferator-activated-receptor-%C3%AE-mediated-polarization-of-macrophages-in-neospora-caninum-infection
#4
Xuexiu He, Pengtao Gong, Zhengkai Wei, Weijian Liu, Weili Wang, Jianhua Li, Zhengtao Yang, Xichen Zhang
BACKGROUND: Neospora caninum is an apicomplexan parasite closely related Toxoplasma gondii, which causes neurological disease and abortion in multiple animal species. Macrophage polarization plays an important role in host immune responses to parasites infection, such as Toxoplasma gondii, Leishmania, Trypanosoma cruzi. However, the dynamics of macrophage polarization, as well as the possible mechanism that regulate macrophage polarization, during N. caninum infection remains unclear...
May 17, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28527292/-triatoma-dimidiata-in-colombia-distribution-ecology-and-epidemiological-importance
#5
Óscar Quirós-Gómez, Nicolás Jaramillo, Víctor Angulo, Gabriel Parra-Henao
Triatoma dimidiata is an important vector of Chagas disease in Central America and countries of northern South America. In Colombia, it has a wide geographical distribution with reported presence in 14 departments in the Andean, Caribbean, Eastern plains and Upper Magdalena regions, where it occupies different natural and artificial ecotopes. The species is considered a secondary vector in the transmission of Trypanosoma cruzi. Its presence in wild, peridomestic and intradomiciliary habitats in the Andean region, coupled with its ability to move between them, has allowed it to escape the control based on pyrethroids spraying, highlighting its importance in maintaining transmission of the parasite through the potential reinfestation of homes...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527286/-possible-oral-transmission-of-chagas-disease-among-hydrocarbons-sector-workers-in-casanare-colombia-2014
#6
Liliana Patricia Zuleta-Dueñas, Ángela Johana López-Quiroga, Fernando Torres-Torres, Oneida Castañeda-Porras
INTRODUCTION: Trypanosoma cruzi, the etiological agent for Chagas disease, can be transmitted by oral intake of contaminated food or drinks. During epidemiological week 14 of 2014, two cases of acute Chagas disease were notified among hydrocarbons sector workers in Paz de Ariporo, Casanare. OBJECTIVE: To characterize the affected population, to establish control and prevention measures and to confirm the outbreak. MATERIALS AND METHODS: We conducted an outbreak investigation that included the following components: a) Search for symptomatic people compatible with Chagas disease according to the case definition for their referral to medical services; b) entomological survey (192/197 houses); c) sanitary inspection and microbiological analysis of food samples; and d) study of reservoirs...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527250/-risk-of-transmission-of-chagas-disease-by-intrusion-of-triatomines-and-wild-mammals-in-bucaramanga-santander-colombia
#7
Marlene Reyes, Ángela Torres, Lyda Esteban, Mónica Flórez, Víctor Manuel Angulo
INTRODUCTION: Notice of triatomines in dwellings of some neighborhoods in Bucaramanga motivated the realization of this study.Objetive: To evaluate the intrusion of triatomines and mammals, as well as some risk factors in urban dwellings. MATERIALS AND METHODS: Triatomines were collected in a neighborhood in Bucaramanga, Santander, on a monthly basis during one year with participation of the community. Collection included manual search in lamp posts, use of light traps, animal bait, and chemical attractants in nearby forests...
January 24, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527247/-diversity-of-triatominae-hemiptera-reduviidae-in-santander-colombia-epidemiological-implications
#8
Lyda Esteban, José Mauricio Montes, Víctor Manuel Angulo
INTRODUCTION: Domestic and wild triatomines in the department of Santander have an epidemiological impact, as recently they have been linked to outbreaks of acute Chagas disease. The analysis of their diversity and temporal variation contributes to the understanding of their biology and ecology in one of the most endemic areas of the country. OBJECTIVES: To analyze triatominae diversity in two regions of Santander. MATERIALS AND METHODS: We analyzed the triatomine records for Santander contained in the CINTROP-UIS entomology lab database...
January 24, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28524628/myenteric-neuroprotective-role-of-aspirin-in-acute-and-chronic-experimental-infections-with-trypanosoma-cruzi
#9
J Y Oda, M O Belém, T M Carlos, R Gouveia, B F C Luchetti, N M Moreira, C L Massocatto, S M Araújo, D M G Sant Ana, N C Buttow, P Pinge-Filho, E J A Araújo
BACKGROUND: Experimental and clinical studies have shown that myenteric neuron cell death during infection with Trypanosoma cruzi mainly occurs in the esophagus and colon, resulting in megaesophagus and megacolon, respectively. Evidence suggests that the cyclooxygenase enzyme (COX) is involved in the T. cruzi invasion process. The use of low-dose aspirin (ASA), a COX-1/COX-2 inhibitor, has been shown to reduce infection with T. cruzi. Therefore, in this study, we evaluated the effects of treatment with low-dose ASA on myenteric colonic neurons during murine infection with T...
May 19, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28522273/trypanosoma-cruzi-over-the-ocean-insular-zones-of-chile-with-presence-of-infected-vector-mepraia-species
#10
Ninette Rives-Blanchard, Fernando Torres-Pérez, Silvia Ortiz, Aldo Solari, Ricardo Campos-Soto
Chagas disease is one of the main zoonosis mediated by vectors in America. The etiologic agent Trypanosoma cruzi infects different mammals and is transmitted principally by the subfamily Triatominae. Mepraia is a genus endemic to Chile, responsible for transmitting T. cruzi in the sylvatic cycle. Mepraia includes three species: M. gajardoi and M. parapatrica inhabit coastal areas, while M. spinolai inhabits coastal and interior valleys. Previous studies reported the occurrence of Mepraia in Pan de Azucar Island, currently classified as M...
May 15, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28521262/rhodium-catalyzed-c-h-bond-activation-for-the-synthesis-of-quinonoid-compounds-significant-anti-trypanosoma-cruzi-activities-and-electrochemical-studies-of-functionalized-quinones
#11
Guilherme A M Jardim, Thaissa L Silva, Marilia O F Goulart, Carlos A de Simone, Juliana M C Barbosa, Kelly Salomão, Solange L de Castro, John F Bower, Eufrânio N da Silva Júnior
Thirty four halogen and selenium-containing quinones, synthesized by rhodium-catalyzed C-H bond activation and palladium-catalyzed cross-coupling reactions, were evaluated against bloodstream trypomastigotes of T. cruzi. We have identified fifteen compounds with IC50/24 h values of less than 2 μM. Electrochemical studies on A-ring functionalized naphthoquinones were also performed aiming to correlate redox properties with trypanocidal activity. For instance, (E)-5-styryl-1,4-naphthoquinone 59 and 5,8-diiodo-1,4-naphthoquinone 3, which are around fifty fold more active than the standard drug benznidazole, are potential derivatives for further investigation...
May 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28515890/sex-dependent-infection-causes-nonadditive-effects-on-kissing-bug-fecundity
#12
Carezza Botto-Mahan, Verónica Campos, Rodrigo Medel
The influence of parasites on host reproduction has been widely studied in natural and experimental conditions. Most studies, however, have evaluated the parasite impact on female hosts only, neglecting the contribution of males for host reproduction. This omission is unfortunate as sex-dependent infection may have important implications for host-parasite associations. Here, we evaluate for the first time the independent and nonindependent effects of gender infection on host reproductive success using the kissing bug Mepraia spinolai and the protozoan Trypanosoma cruzi as model system...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28513328/trypanosoma-cruzi-in-free-ranging-mammalian-populations-in-south-texas
#13
Mathew M Kramm, Maria R Gutierrez, Troy D Luepke, Cynthia Soria, Roel R Lopez, Susan M Cooper, Donald S Davis, Israel D Parker
Chagas disease, also known as American trypanosomiasis, is caused by the flagellate protozoan Trypanosoma cruzi. It is a significant health concern in South and Central America, where millions of people are infected or at risk of infection, and is an emerging health concern in the United States. The occurrence of Chagas disease in natural environments is supported by mammal host species, but those primary species may vary based on geographic location. In South Texas, the primary host species for the disease is poorly understood, and required a field study to determine the spatial distribution of T...
May 17, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28511704/the-use-of-kdna-minicircle-subclass-relative-abundance-to-differentiate-between-leishmania-l-infantum-and-leishmania-l-amazonensis
#14
Marcello Ceccarelli, Luca Galluzzi, Aurora Diotallevi, Francesca Andreoni, Hailie Fowler, Christine Petersen, Fabrizio Vitale, Mauro Magnani
BACKGROUND: Leishmaniasis is a neglected disease caused by many Leishmania species, belonging to subgenera Leishmania (Leishmania) and Leishmania (Viannia). Several qPCR-based molecular diagnostic approaches have been reported for detection and quantification of Leishmania species. Many of these approaches use the kinetoplast DNA (kDNA) minicircles as the target sequence. These assays had potential cross-species amplification, due to sequence similarity between Leishmania species. Previous works demonstrated discrimination between L...
May 16, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28511274/a-case-of-chagas-cardiomyopathy-following-infection-in-south-central-texas
#15
Bryant J Webber, Edward J Wozniak, David Chang, Kelvin N Bush, Matthew C Wilson, James A Watts, Heather C Yun
Between 5 and 8 million people globally are infected with Trypanosoma cruzi, the causative parasitic agent of Chagas disease. The vast majority of incident infections originate in pockets of Latin America where domestic vector-borne transmission cycles are more common. Since 1955, when the first locally-acquired case was reported, fewer than 30 autochthonous cases have been documented in the United States. We describe the case of an 18-year-old US Air Force trainee, a native Texan with no travel history beyond the continental United States, who screened positive for T cruzi infection on blood donation and was subsequently found to have chronic Chagasic cardiomyopathy...
January 2017: U.S. Army Medical Department Journal
https://www.readbyqxmd.com/read/28509592/molecular-modeling-and-structure-activity-relationships-for-a-series-of-benzimidazole-derivatives-as-cruzain-inhibitors
#16
Ivani Pauli, Leonardo G Ferreira, Mariana L de Souza, Glaucius Oliva, Rafaela S Ferreira, Marco A Dessoy, Brian W Slafer, Luiz C Dias, Adriano D Andricopulo
AIM: Chagas disease is endemic in Latin America and no effective treatment is available. Efforts in drug research have focused on several enzymes from Trypanosoma cruzi, among which cruzain is a validated pharmacological target. METHODOLOGY: Chemometric analyses were performed on the data set using the HQSAR, CoMFA and CoMSIA methods. Docking simulations were executed using the crystallographic structure of cruzain in complex with a benzimidazole inhibitor. The top-scoring enzyme-inhibitor complexes were selected for the development of the 3D QSAR models and to assess the inhibitor binding modes and intermolecular interactions...
May 16, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28507520/in-vitro-and-in-silico-antidiabetic-and-antimicrobial-evaluation-of-constituents-from-kickxia-ramosissima-nanorrhinum-ramosissimum
#17
Adnan Amin, Emmy Tuenter, Kenn Foubert, Jamhsed Iqbal, Paul Cos, Louis Maes, Vassiliki Exarchou, Sandra Apers, Luc Pieters
Background and Aims:Kickxia ramosissima (Wall.) Janch (or Nanorrhinum ramosissimum (Wall.) Betsche is a well-known medicinal plant in Pakistan that is traditionally used in diabetic and inflammatory conditions. Because little information is available on its phytochemical composition, a range of constituents were isolated and evaluated in vitro in assays related to the traditional use. Methods: Dried whole plant material was extracted and chromatographically fractionated. Isolated constituents were evaluated in silico and in vitro in assays related to the traditional use against diabetes (inhibition of α-glucosidase activity; inhibition of advanced glycation endproducts) and in inflammatory conditions (inhibition of AAPH induced linoleic acid peroxidation, inhibition of 15-LOX, antimicrobial activity)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28506517/fish-oil-supplementation-benefits-the-murine-host-during-the-acute-phase-of-a-parasitic-infection-from-trypanosoma-cruzi
#18
Maria I Lovo-Martins, Aparecida D Malvezi, Rosiane V da Silva, Nágela G Zanluqui, Vera L H Tatakihara, Niels O S Câmara, Ana Paula L de Oliveira, Jean P S Peron, Marli C Martins-Pinge, Kevin L Fritsche, Phileno Pinge-Filho
Long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) are known to modulate a variety of immune cell functions. On occasion, this has led to diminished host resistance to certain viral and bacterial infections. Little is known about the impact of n-3 PUFA on host resistance to parasitic infection, however, based on results from a small study conducted more than two decades ago, we hypothesized that providing mice LC n-3 PUFA will diminish host resistance to Trypanosoma cruzi, the parasitic pathogen responsible for Chagas disease...
April 25, 2017: Nutrition Research
https://www.readbyqxmd.com/read/28502864/chagas-disease-in-europe-a-review-for-the-internist-in-the-globalized-world
#19
REVIEW
Spinello Antinori, Laura Galimberti, Roberto Bianco, Romualdo Grande, Massimo Galli, Mario Corbellino
Chagas disease (CD) or American trypanosomiasis identified in 1909 by Carlos Chagas, has become over the last 40years a global health concern due to the huge migration flows from Latin America to Europe, United States, Canada and Japan. In Europe, most migrants from CD-endemic areas are concentrated in Spain, Italy, France, United Kingdom and Switzerland. Pooled seroprevalence studies conducted in Europe show an overall 4.2% prevalence, with the highest infection rates observed among individuals from Bolivia (18...
May 11, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28500812/the-prevalence-of-chagas-disease-among-latin-american-immigrants-with-pacemakers-in-los-angeles-california
#20
Sandy Park, Daniel R Sanchez, Mahmoud I Traina, Jason S Bradfield, Salvador Hernandez, Alvaro Joaquin Altamirano Ufion, Jalal Dufani, Patrick Bergin, Robin Y Wachsner, Sheba K Meymandi
AbstractChagas disease (CD), with associated conduction abnormalities, is a common indication for pacemaker implantation in Latin America. The prevalence of CD in Latin American immigrants with pacemakers residing in the United States has never been studied. This single-center cross-sectional study included pacemaker patients who were aged 18 years or more with a previous residence in Latin America for at least 6 months. Patients with an implantable cardioverter-defibrillator, cardiac resynchronization therapy, or iatrogenic and/or congenital heart block were excluded...
May 2017: American Journal of Tropical Medicine and Hygiene
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