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Inmune response

J Benitez-Del-Castillo Sánchez, M D Morillo-Rojas, C Galbis-Estrada, M D Pinazo-Duran
OBJECTIVE: To determine the expression profile of immune response and inflammation (IRI) mediator molecules in tears from patients with dry eye (DE), and those suspected of having or have primary open-angle glaucoma (POAG) under treatment and compare them with healthy controls. METHODS: A prospective observational cohort study including 107 participants sub-divided into: healthy controls (CG; n=30), patients with DE (DEG; n=41) and patients suspected of having or have POAG and on hypotensive treatment (POAG-G; n=36)...
February 3, 2017: Archivos de la Sociedad Española de Oftalmología
Lorena Martín-Jaular, Armando de Menezes-Neto, Marta Monguió-Tortajada, Aleix Elizalde-Torrent, Míriam Díaz-Varela, Carmen Fernández-Becerra, Francesc E Borras, Maria Montoya, Hernando A Del Portillo
Reticulocyte-derived exosomes (rex) are 30-100 nm membrane vesicles of endocytic origin released during the maturation of reticulocytes to erythrocytes upon fusion of multivesicular bodies with the plasma membrane. Combination of CpG-ODN with rex obtained from BALB/c mice infected with the reticulocyte-prone non-lethal P. yoelii 17X malaria strain (rexPy), had been shown to induce survival and long lasting protection. Here, we show that splenectomized mice are not protected upon rexPy+CpG inmunizations and that protection is restored upon passive transfer of splenocytes obtained from animals immunized with rexPy+CpG...
2016: Frontiers in Cell and Developmental Biology
Anju Seth, Sudha Deepa, Renu Dutta, Jagdish Chandra
BACKGROUND: Children with HIV (CLHIV) respond poorly to primary immunization with measles vaccine and those responding tend to lose protective titer of antibodies by 2-3 years old. Revaccinating CLHIV after immune reconstitution with antiretroviral therapy (ART) may result in good seroconversion, thereby conferring them protection from measles. The objective was to study prevalence of measles antibodies in CLHIV receiving ART before and after immunization with MMR vaccine. METHODS: CLHIV in the age 5-18 years receiving ART for >6 months and with CD 4 count >15% were included in this prospective study...
January 2016: Pediatric Infectious Disease Journal
Cecília Maria Passos Vázquez, Raquel Simões Mendes Netto, Kiriaque Barra Ferreira Barbosa, Tatiana Rodrigues de Moura, Roque Pacheco de Almeida, Malcolm S Duthie, Amelia Ribeiro de Jesus
Leprosy is a chronic infectious disease caused by Mycobacterium leprae, an intracellular bacillus of airborne transmission. The disease affects the skin and peripheral nerves and can cause neurological sequelae. The bacillus multiplies slowly in the host and the disease probably occurs due to malfunctioning in host immune response. This review addresses the role of some specific micronutrients in the immune response, such as Vitamins A, D, E, C, Zinc and Selenium, detailing their mechanisms of actions in infectious diseases, and in leprosy...
January 1, 2014: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
P Casas Rodera, D A de Luis, C Gómez Candela, J M Culebras
INTRODUCTION: Significant malnutrition exists in a high percentage of patients with head and neck cancer. Malnutrition is associated with defects in immune function that may impair the host response to malignancy. Malnutrition and immunosupression make patients highly susceptible to postoperative infections and complications. OBJECTIVES: Some studies of patients receiving immuno-nutrition in the perioperative period in head and neck cancer have shown beneficial effects on clinical outcome and inmune status...
May 2012: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Miguel A Zambrano-Velarde, Daniel de la O-Peña, Quetzalcóatl Chávez-Peña, Martín Bedolla-Barajas
BACKGROUND: immune thrombocytopenic purpura is characterized by bleeding disorders associated with decreased platelet count secondary to antiplatelet autoantibodies. The aim of this study was to evaluate the utility of rituximab in the management of refractory immune thrombocytopenic purpura. CLINICAL CASES: four women with immune thrombocytopenic purpura unresponsiveness to standard therapy were evaluated in relation to clinical response and total platelets counts at different time intervals after rituximab administration...
March 2012: Revista Médica del Instituto Mexicano del Seguro Social
Gerardo A Belletti, Verónica Savio, Daniel Minoldo, Susana Caminos, Marcelo A Yorio
A 66 years female, who was since last year under astenia, arthralgias, pimply lesions in spread plates and tests showing eritrosedimentation over 100 mm, anemi, leucocitosis with neutrofilia, policlonal hypergammaglobulinemia, slight proteinuria and IgE on 900. This patient was sporadically treated with corticoids. When made the medical consult had lost 34lb., was under anorexy, as well as dyspepsia. Hemoglobyn 6.9 gr/dl, leucocytes 20000/mm3, neutrofils at 90%, proteinogram the same as former, with hypoalbuminemia...
2004: Revista de la Facultad de Ciencias Médicas
Shi-Fang Yuan, Kai-Zong Li, Ling Wang, Zhen Yan, Wei Han, Ying-Qi Zhang
AIM: To observe the specific cytotoxic T lymphocyte and humoral immune response induced by MUC1 DNA inmunization in mice. METHODS: Female BALB/c mice were immunized intramuscularly with 100 microg pcDNA3.1-MUC1 3 times at intervals of 3 weeks. Three weeks after the last immunization, tumor challenge experiments were performed by inoculation of MUC1 positive breast cancer cell line EMT6. Both humoral immune response and CTL-specific cytotoxicity were detected by immunohistochemical staining and (51)Cr release assay, respectively...
July 2003: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
R Figueroa Barrios R
Great advances has been achieved in the last 10 years in the study of acute and chronic viral hepatitis. The enigma of non-A non-B viral hepatitis was disclosed when C virus was identified and later when E virus was isolated. New viruses has been searched to explain non-A to non-E viral hepatitis, being reported recently G virus. Epidemiology and clinical aspects has been reviewed identifying unusual clinical forms: choletasic and relapsing hepatitis in HAV infection; escape mutants B virus hepatitis in HVB infection; and the silent evolution to chronicity in more than 70% of cases in HVC infection...
September 1996: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
J L Mankowski, D L Carter, J P Spelman, M L Nealen, K R Maughan, L M Kirstein, P J Didier, R J Adams, M Murphey-Corb, M C Zink
Although many human immunodeficiency virus-infected individuals develop lymphocytic interstitial pneumonia, the roles of host and viral factors in the pathogenesis of pneumonia are not well defined. Human immunodeficiency virus-infected children with lymphocytic interstitial pneumonia have human immunodeficiency virus-specific cytotoxic T cells in pulmonary infiltrates, increased survival time, and a reduced incidence of opportunistic infections, suggesting that lymphocytic interstitial pneumonia may reflect an effective antiviral immune response...
October 1998: American Journal of Pathology
R H Buckley, F Seymour, S O Sanal, D R Ownby, W G Becker
To evaluate cell-mediated immune responsiveness to pollen allergens in atopic subjects, we studied the deoxyribonucleic acid (DNA) synthetic responses of their cultured lymphocytes to purified ragweek antigens E, K, and Ra-3. Since lymphocytes from some highly ragweed-sensitive subjects gave poor proliferative responses when harvested on day 6, we undertook a series of dose-response and time-course studies in atopic and control subjects. Surprisingly, vigorous DNA synthetic responses to antigen E occurred with lymphocytes from all 45 subjects, including 19 highly ragweed-sensitive atopic and control subjects...
January 1977: Journal of Allergy and Clinical Immunology
T Ishibashi, Y Harada, S Harada, H Yamada, M Takamoto, K Sugiyama
The mode of action of BCG, strain Japan was investigated using the immune response to sheep red blood cells (SRBC) as an indicator system. When SRBC were injected into the BCG-primed foot pad, the direct plaque forming cells (PFC) and the effector cells responsible for delayed type hypersensitivity (PTH) were produced in various lymphoid organs widely distributed. Furthermore, bacterial counts in the draining popliteal lymph node and the spleen in the mice inoculated with BCG into the hind foot pad suggested that a local infection with BCG has spread to a generalized systemic infection of lymphoid tissues with time...
June 1978: Japanese Journal of Experimental Medicine
R Ruiz-Requena, F Garrido, A Martín-Andrés, C Osorio
The capacity of human foetal lymphocytes to respond to PHA and to form E-rosettes have been compared with data from adult individuals. For this purpose a microculture system that uses whole blood and avoids the problems of lymphocyte separation, has been developed. Foetal lymphocytes reached optimal stimulation with lower dosis of PHA (31,2 microgram/ml) as compared with adult cells (125-252 microgram/ml). However their quantitative response (measured by 14C-thymidine uptake) was equal in both groups. In addition, peripheral T cells (E-rosetting cells) reached values of 36...
September 1977: Revista Española de Fisiología
P A Reyes López
American trypanosoniasis or Chagas' Disease is a serious health problem in Latin America. Schizotrypanum (Trypanosome) cruzi infection produce an inmune response, cellular and humoral well identified in all mammals so far studied, including man. The initial parasistemic disease is brought promptly under control, maybe as result of such inmune response. Chronical disease result of individual responses, through inmune aberration as main pathogenic factor. There is not, and there is no probability to develop it in a short time, suitable inmunoprophylaxis for Chagas' disease...
September 1978: Archivos del Instituto de Cardiología de México
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