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https://www.readbyqxmd.com/read/29245000/does-traumatic-brain-injury-hold-the-key-to-the-alzheimer-s-puzzle
#1
Robert E Becker, Dimitrios Kapogiannis, Nigel H Greig
INTRODUCTION: Neurodegenerative disorders have been a graveyard for hundreds of well-intentioned efforts at drug discovery and development. Concussion and other traumatic brain injuries (TBIs) and Alzheimer's disease (AD) share many overlapping pathologies and possible clinical links. METHODS: We searched the literature since 1995 using MEDLINE and Google Scholar for the terms concussion, AD, and shared neuropathologies. We also studied a TBI animal model as a supplement to transgenic (Tg) mouse AD models for evaluating AD drug efficacy by preventing neuronal losses...
December 12, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29244969/treatment-of-open-upper-limb-injuries-with-infection-prevention-and-negative-pressure-wound-therapy-a-systematic-review
#2
E Ali, M Raghuvanshi
OBJECTIVE: Open upper limb injuries requiring soft reconstruction can pose a dilemma for trauma surgeons when considering the treatment options. The British Orthopaedic Association and British Association of Plastic, Reconstructive and Aesthetic Surgeons Standard for Trauma (BOAST) have addressed the management of severe open lower limb fractures with the creation of the BOAST 4 guidelines. However, no such gold standard exists for the treatment of open injuries of the upper limb. Furthermore, treatment of these injuries is often more difficult and requires complicated strategies...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29244832/productivity-impact-and-collaboration-differences-between-transdisciplinary-and-traditionally-trained-doctoral-students-a-comparison-of-publication-patterns
#3
Anna-Sigrid Keck, Stephanie Sloane, Janet M Liechty, Barbara H Fiese, Sharon M Donovan
Transdisciplinary (TD) approaches are increasingly used to address complex public health problems such as childhood obesity. Compared to traditional grant-funded scientific projects among established scientists, those designed around a TD, team-based approach yielded greater publication output after three to five years. However, little is known about how a TD focus throughout graduate school training may affect students' publication-related productivity, impact, and collaboration. The objective of this study was to compare the publication patterns of students in traditional versus TD doctoral training programs...
2017: PloS One
https://www.readbyqxmd.com/read/29244785/co-authorship-and-scientific-collaboration-networks-in-medwave
#4
Ibraín Enrique Corrales-Reyes
Scientific collaboration between researchers is one of the most important aspects in the evolution of science helping promote the quality of the studies that are carried out. In turn, it determines an increase in citations when research results are published in scholarly journals. It is interesting to explore the dynamics of scientific collaboration networks regarding co-authorship of scientific articles published in Medwave from January 2014 to September of 2017 and indexed in PubMed/MEDLINE. The largest collaboration networks occurred among authors Rada G, Corsi O and Peña J; and, at universities and healthcare centers level, in the Faculty of Medicine belonging to the Pontificia Universidad Católica de Chile located in Santiago, Chile...
December 15, 2017: Medwave
https://www.readbyqxmd.com/read/29244776/internet-of-things-iot-based-design-of-a-secure-and-lightweight-body-area-network-ban-healthcare-system
#5
Yong-Yuan Deng, Chin-Ling Chen, Woei-Jiunn Tsaur, Yung-Wen Tang, Jung-Hsuan Chen
As sensor networks and cloud computation technologies have rapidly developed over recent years, many services and applications integrating these technologies into daily life have come together as an Internet of Things (IoT). At the same time, aging populations have increased the need for expanded and more efficient elderly care services. Fortunately, elderly people can now wear sensing devices which relay data to a personal wireless device, forming a body area network (BAN). These personal wireless devices collect and integrate patients' personal physiological data, and then transmit the data to the backend of the network for related diagnostics...
December 15, 2017: Sensors
https://www.readbyqxmd.com/read/29244536/dietary-intake-of-fish-n-3-polyunsaturated-fatty-acids-and-risk-of-hip-fracture-a-systematic-review-and-meta-analysis-on-observational-studies
#6
Omid Sadeghi, Kurosh Djafarian, Sima Ghorabi, Mahmoud Khodadost, Morteza Nasiri, Sakineh Shab-Bidar
Previous studies have shown that fish consumption and dietary intake of n-3 polyunsaturated fatty acids (n-3 PUFAs) are associated with hip fracture; however, findings were conflicting. The present review aimed to summarize the current evidence on the association of fish consumption and dietary intake of n-3 PUFAs with hip fracture. The online databases of PubMed, ISI Web of Science, Scopus, ProQuest, Science Direct and Embase were searched until August 2017 for related publications using relevant keywords...
December 15, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29244533/systematic-overview-of-neuroanatomical-differences-in-adhd-definitive-evidence
#7
Bruno Bastos Vieira de Melo, Maria João Trigueiro, Pedro Pereira Rodrigues
OBJECTIVES: This article seeks to identify neuroanatomical differences in ADHD through an overview of systematic reviews that report encephalic differences compared to a control group in volume, area, activation likelihood or chemical composition. METHODS: We conducted a systematic search using Cochrane guidelines and PRISMA criteria in PubMed, Scopus, Web of Science, Cochrane Database of Systematic Reviews and Database of Abstracts of Reviews of Effects. RESULTS: Results revealed broad encephalic involvement that includes a functional frontal and cingulate hypoactivation and structural differences in corpus callosum, cerebellum and basal nuclei...
December 15, 2017: Developmental Neuropsychology
https://www.readbyqxmd.com/read/29244099/the-role-of-vitamin-d-in-adipogenesis
#8
Clare F Dix, Johanna L Barcley, Olivia R L Wright
Vitamin D, a secosteroid predominately obtained by endogenous production, has in recent years been linked to obesity and its comorbidities. The purpose of this review is to draw conclusions from animal and human studies on the effects of vitamin D on adipogenesis to identify the molecular links between vitamin D and obesity. The information presented herein was obtained from 4 databases (PubMed, CINAHL, Cochrane Library, Scopus) using predefined search terms, as well as research literature and other reviews...
December 13, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/29243858/atrial-fibrillation-and-risk-of-cardiovascular-events-and-mortality-in-patients-with-symptomatic-peripheral-artery-disease-a-meta-analysis-of-prospective-studies
#9
Mislav Vrsalović, Ana Vrsalović Presečki
BACKGROUND: Atrial fibrillation (AF) is associated with adverse outcomes in terms of survival and morbidity. Peripheral artery disease (PAD) and AF share several common risk factors and often coexist. Whether AF has a prognostic role in patients with PAD has not been extensively studied. HYPOTHESIS: AF is associated with major adverse cardiac events (MACE) and mortality in symptomatic PAD patients. METHODS: Using MEDLINE and Scopus, we searched for studies published before December 2016 that evaluated cardiovascular outcomes based on the presence/absence of AF in a prospective manner with a follow-up period of ≥12 months...
December 15, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29243813/antiepileptic-drug-monotherapy-for-epilepsy-a-network-meta-analysis-of-individual-participant-data
#10
REVIEW
Sarah J Nevitt, Maria Sudell, Jennifer Weston, Catrin Tudur Smith, Anthony G Marson
BACKGROUND: Epilepsy is a common neurological condition with a worldwide prevalence of around 1%. Approximately 60% to 70% of people with epilepsy will achieve a longer-term remission from seizures, and most achieve that remission shortly after starting antiepileptic drug treatment. Most people with epilepsy are treated with a single antiepileptic drug (monotherapy) and current guidelines from the National Institute for Health and Care Excellence (NICE) in the United Kingdom for adults and children recommend carbamazepine or lamotrigine as first-line treatment for partial onset seizures and sodium valproate for generalised onset seizures; however a range of other antiepileptic drug (AED) treatments are available, and evidence is needed regarding their comparative effectiveness in order to inform treatment choices...
December 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29243749/association-between-berries-intake-and-cardiovascular-diseases-risk-factors-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis-of-randomized-controlled-trials
#11
REVIEW
Ângelo Luís, Fernanda Domingues, Luísa Pereira
The main goal of this work was to clarify the effects of the consumption of berries on cardiovascular disease (CVD) risk factors by performing a systematic review according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) statement, followed by a meta-analysis and a trial sequential analysis (TSA) of randomized controlled trials (RCTs). The electronic search was conducted in PubMed, Scopus, SciELO, Web of Science and Cochrane Library between April and June 2016. To be included, RCTs had to report 1 or more of the following outcomes: total cholesterol (TC), HDL-cholesterol (HDL), LDL-cholesterol (LDL), triglycerides (TG), blood pressure (BP), C-reactive protein (CRP), tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), vascular cell adhesion molecule-1 (VCAM), intercellular adhesion molecule-1 (ICAM), glucose, insulin, apolipoprotein A-I (Apo A-I) or apolipoprotein B (Apo B)...
December 15, 2017: Food & Function
https://www.readbyqxmd.com/read/29243680/a-review-of-peek-polymer-s-properties-and-its-use-in-prosthodontics
#12
Gediminas Skirbutis, Agnė Dzingutė, Viltė Masiliūnaitė, Gabrielė Šulcaitė, Juozas Žilinskas
OBJECTIVE: The aim of this study is to review polyether ether ketone (PEEK), its characteristics and use in prosthodontics. MATERIAL AND METHODS: Information search for articles about PEEK and it's use in prosthodontics between January 2010 and April 2017 was conducted in Medline via PubMed, Science direct, Wiley online library as well as the Web search Google Scholar sources. Twelve full text articles were selected and used in this review. RESULTS: 143 articles were found in the database using keywords: PEEK, prosthodontics, dentistry...
2017: Stomatologija
https://www.readbyqxmd.com/read/29243456/robotic-versus-laparoscopic-sleeve-gastrectomy-a-review-of-the-current-evidence
#13
Vasiliki S Tasiopoulou, Alexis A Svokos, Konstantina A Svokos, Dimitrios Zacharoulis, Dimitrios E Magouliotis
INTRODUCTION: The purpose of the present study was to review the existing evidence on obese patients treated with either robotic or laparoscopic sleeve gastrectomy, in order to compare the clinical and perioperative outcomes of the two methods. EVIDENCE ACQUISITION: A systematic literature search was performed in PubMed, Cochrane library and Scopus databases. EVIDENCE SYNTHESIS: Sixteen studies were included in the present review and incorporated 29,787 patients...
December 14, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/29243356/turning-frequency-in-adult-bedridden-patients-to-prevent-hospital-acquired-pressure-ulcer-a-scoping-review
#14
Chew H-S Jocelyn, Emelia Thiara, Violeta Lopez, Shefaly Shorey
The aim of this study was to identify current research on turning frequencies of adult bed-bound patients and inform future turning practices for hospitals based on evidence-based practice. We undertook a scoping review framework that provided a transparent and systematic methodology using 8 electronic databases (CINAHL, PubMed, Cochrane Library, ScienceDirect, PsycINFO, Scopus, ProQuest, and Web of Science) to identify articles published from 2000 to 2016. Articles were included if they focused on the prevention of hospital-acquired pressure ulcers related to the frequency of turning or repositioning of bed-bound patients...
December 15, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29242057/quality-of-audio-assisted-versus-video-assisted-dispatcher-instructed-bystander-cardiopulmonary-resuscitation-a-systematic-review-and-meta-analysis
#15
Yu-You Lin, Ming-Ju Hsieh, Jen-Tang Sun, Yi-Chung Chang, Matthew Huei-Ming Ma, Wen-Chu Chiang
AIM: This study aimed to conduct a systematic review and meta-analysis comparing the effect of video-assistance and audio-assistance on quality of dispatcher-instructed cardiopulmonary resuscitation (DI-CPR) for bystanders. METHODS: Five databases were searched, including PubMed, Cochrane library, Embase, Scopus and NIH clinical trial, to find randomized control trials published before June 2017. Qualitative analysis and meta-analysis were undertaken to examine the difference between the quality of video-instructed and audio-instructed dispatcher-instructed bystander CPR...
December 11, 2017: Resuscitation
https://www.readbyqxmd.com/read/29242019/global-variations-in-the-level-of-cancer-related-research-activity-and-correlation-to-cancer-specific-mortality-proposal-for-a-global-curriculum
#16
C Are, A Caniglia, Mohammed Malik, L Smith, Charmaine Cummings, Carine Lecoq, R Berman, R Audisio, L Wyld
INTRODUCTION: The aim of this study was to analyze global variations in the level of cancer-related research activity and correlate this with cancer-specific mortality. METHODS: The SCOPUS database was explored to obtain data relating to the number of cancer-related publications per country. Cancer-specific mortality rates were obtained from the World Health Organization. Global variations in the level of scholarly activity were analyzed and correlated with variations in cancer-specific mortality...
December 7, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29241707/expression-of-the-dj-1-protein-in-the-serum-of-chinese-patients-with-parkinson-s-disease
#17
Chunna An, Xiaoping Pu, Weizhong Xiao, Hongning Zhang
DJ-1 is one of the important genes found in Parkinson's disease (PD). Studies have shown that the DJ-1 protein levels are elevated in the cerebrospinal fluid (CSF) and plasma of sporadic PD patients, and the DJ-1 protein levels in the CSF and plasma may serve as biomarkers of PD. However, Japanese scholars previously reported that there was no difference in the levels of the DJ-1 protein in serum between sporadic PD patients and controls. Therefore, whether the serum DJ-1 protein levels are different between PD patients and controls in Chinese patients as well as whether serum DJ-1 protein can serve as a biomarker of PD are unknown...
December 11, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29241672/catatonia-with-schizophrenia-from-ect-to-rtms
#18
E Stip, M-E Blain-Juste, O Farmer, M-P Fournier-Gosselin, P Lespérance
BACKGROUND: Electroconvulsive therapy is indicated in cases of catatonic schizophrenia following a failure of the challenge test with lorazepam or Zolpidem®. Some patients need maintenance treatment with ECT. Repetitive Transcranial Magnetic Stimulation (rTMS) and anodal Transcranial direct-current stimulation (tDCS) might be effective against catatonia. OBJECTIVE: Consider an alternative to ECT for a refractory patient. REVIEW: Twenty-one articles were identified mainly based on case reports series were found using search on Medline, Google Scholar, PsychInfo, CAIRNS...
December 11, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29241343/can-biologic-augmentation-improve-clinical-outcomes-following-microfracture-for-symptomatic-cartilage-defects-of-the-knee-a-systematic-review
#19
Armin Arshi, Peter D Fabricant, Derek E Go, Riley J Williams, David R McAllister, Kristofer J Jones
Objective To perform a systematic review of clinical outcomes following microfracture augmented with biological adjuvants (MFX+) compared with microfracture (MFX) alone. Design The MEDLINE, Scopus, and Cochrane databases were searched for clinical studies on MFX+ for chondral defects of the knee. Study characteristics and clinical outcome score data were collected. Subjective synthesis was performed using data from randomized controlled studies to determine effect size of MFX+ procedures performed with either injectable or scaffold-based augmentation compared with MFX alone...
December 1, 2017: Cartilage
https://www.readbyqxmd.com/read/29241341/abaloparatide-review-of-a-next-generation-parathyroid-hormone-agonist
#20
Eric G Boyce, Yvonne Mai, Christopher Pham
OBJECTIVE: To review the efficacy, safety, and economics of abaloparatide in the treatment of postmenopausal osteoporosis. DATA SOURCES: PubMed (1966 to October 2017), Clinicaltrials.gov (October 2017), and Scopus (1970 to October 2017) were searched using abaloparatide, Tymlos, BA058, PTHrP 1-34 analog, and parathyroid hormone-related peptide 1-34 analog. STUDY SELECTION AND DATA EXTRACTION: Human studies published in peer-reviewed publications in English were the primary sources for efficacy, safety, and economic data...
December 1, 2017: Annals of Pharmacotherapy
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