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https://www.readbyqxmd.com/read/28241330/a-qualitative-interview-based-study-of-the-health-policy-fellowship-s-osteopathic-identity
#1
Daniel Skinner, Berkeley Franz
CONTEXT: Since 1993, the Health Policy Fellowship (HPF) has trained osteopathic professionals in health policy and leadership. Although almost 250 fellows have graduated from the program, many of whom have assumed leadership roles within the osteopathic medical profession, the HPF has, to the authors' knowledge, never been subjected to scholarly analysis. OBJECTIVE: To understand the HPF's professional significance as a health policy and leadership training program that has enrolled mostly osteopathic physicians...
March 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28241279/thiazolidinediones-and-advanced-liver-fibrosis-in-nonalcoholic-steatohepatitis-a-meta-analysis
#2
Giovanni Musso, Maurizio Cassader, Elena Paschetta, Roberto Gambino
Importance: Nonalcoholic steatohepatitis (NASH) is projected to be the leading cause of liver transplantation by 2020. Advanced fibrosis (stage F3-F4) on liver biopsy independently predicts all-cause and liver-related mortality in NASH. There are no known efficacious treatments for advanced fibrosis related to NASH. Thiazolidinedione therapy has been extensively evaluated in NASH, and new randomized clinical trials (RCTs) of its efficacy have been completed. Objective: To synthesize the evidence about the association of thiazolidinedione therapy with advanced liver fibrosis in NASH...
February 27, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28240857/metal-organic-inorganic-nanocomposite-thermal-interface-materials-with-ultra-low-thermal-resistances
#3
Cengiz Yegin, Nirup Nagabandi, Xuhui Feng, Charles King, Massimo Catalano, Jun Kyun Oh, Ansam Talib, Ethan A Scholar, Stanislav V Verkhoturov, Tahir Cagin, Alexei V Sokolov, Moon J Kim, Kaiser Matin, Sreekant Narumanchi, Mustafa Akbulut
As electronic devices get smaller and more powerful, energy density of energy storage devices increases continuously, and moving components of machinery operate at higher speeds, the need for better thermal management strategies is becoming increasingly important. The removal of heat dissipated during the operation of electronic, electrochemical, and mechanical devices is facilitated by high-performance thermal interface materials (TIMs) which are utilized to couple devices to heat sinks. Herein, we report a new class of TIMs involving the chemical integration of boron nitride nanosheets (BNNS), soft organic linkers, and a copper matrix - which are prepared by chemisorption coupled electrodeposition approach...
February 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28240845/genetic-association-of-xrcc1-gene-rs1799782-rs25487-and-rs25489-polymorphisms-with-risk-of-thyroid-cancer-a-systematic-review-and-meta-analysis
#4
Jamal Jafari Nedooshan, Mohammad Forat Yazdi, Hossein Neamatzadeh, Masoud Zare Shehneh, Saeed Kargar, Niloofar Seddighi
Background: A number of case-control studies have evaluated associations between the X-ray cross complementary group 1 protein (XRCC1) gene rs1799782 (Arg194Trp), rs25487 (Arg399Gln) and rs25489 (Arg280His) polymorphisms and thyroid cancer (TC) risk, but the results remain inconclusive. Materials and Methods: A systematic literature search was performed using PubMed and Google Scholar Search. According to defined criteria data were extracted and pooled odds ratios with 95% confidence intervals were calculated under five genetic models...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240771/inappropriate-medication-in-non-hospitalized-patients-with-renal-insufficiency-a-systematic-review
#5
Michael Dörks, Katharina Allers, Guido Schmiemann, Stefan Herget-Rosenthal, Falk Hoffmann
OBJECTIVES: Renal insufficiency is common among older patients and, accordingly, renally excreted drugs may require an adjustment in dosage for them. Rates of non-adherence to renal dosing guidelines range from 19% to 70% across all settings, with the highest rate occurring in outpatient care. However, there is a paucity of research in this field. The main objective of this systematic review is to assess how often drugs are inappropriately prescribed in non-hospitalized patients with renal insufficiency...
February 27, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28240509/community-based-prevalence-of-genital-human-papilloma-virus-hpv-infection-a-systematic-review-and-meta-analysis
#6
Sasidharanpillai Sabeena, Parvati V Bhat, Veena Kamath, Shashikala K Bhat, Sreekumaran Nair, Ravishankar n, Kiran Chandrabharani, Govindakarnavar Arunkumar
Introduction: Cervical cancer probably represents the best-studied human cancer caused by a viral infection and the causal association of this preventable cancer with human papilloma virus (HPV) is well established. Worldwide there is a scarcity of data regarding HPV prevalence with vast differences existing among populations. Objective: The aim of this meta-analysis was to determine the community-based HPV prevalence estimates among asymptomatic women from urban and rural set ups and in participants of cancer screening clinics...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28240353/carbamazepine-versus-phenytoin-monotherapy-for-epilepsy-an-individual-participant-data-review
#7
REVIEW
Sarah J Nevitt, Anthony G Marson, Jennifer Weston, Catrin Tudur Smith
BACKGROUND: This is an updated version of the original Cochrane Review published in Issue 2, 2002 and its subsequent updates in 2010 and 2015.Epilepsy is a common neurological condition in which recurrent, unprovoked seizures are caused by abnormal electrical discharges from the brain. It is believed that with effective drug treatment, up to 70% of individuals with active epilepsy have the potential to become seizure-free and go into long-term remission shortly after starting drug therapy with a single antiepileptic drug in monotherapy...
February 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28239999/glioblastoma-multiforme-a-review-of-its-epidemiology-and-pathogenesis-through-clinical-presentation-and-treatment
#8
Farina Hanif, Kanza Muzaffar, Kahkashan Perveen, Saima M Malhi, Shabana U Simjee
Glioblastoma multiforme (GBM) is one of the most malignant types of central nervous system tumors. Despite advances in treatment modalities it remains largely incurable. The objective of our review is to provide a holistic picture of GBM epidemiology, etiology, pathogenesis, clinical findings and treatment. A literature search was conducted for GBM at PubMed and Google Scholar, with relevant key words like glioblastoma multiforme, pathogenesis, signs and symptoms, treatment etc., and papers published until 2015 were reviewed...
1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28238976/investigating-black-asl-a-systematic-review
#9
Andrea Toliver-Smith, Betholyn Gentry
The authors reviewed the literature regarding linguistic variations seen in American Sign Language. These variations are influenced by region and culture. Features of spoken languages have also influenced sign languages as they intersected, e.g., Black ASL has been influenced by African American English. A literature review was conducted to investigate the existence of Black ASL and to document empirical studies on this topic. The included articles were (a) published between 1970 and 2012 in scholarly journals, (b) included a hypothesis, (c) described the participants, and (d) described the research design...
2017: American Annals of the Deaf
https://www.readbyqxmd.com/read/28238873/cell-salvage-used-in-scoliosis-surgery-is-it-really-effective
#10
REVIEW
Jia-Ming Liu, Bi-Qi Fu, Wen-Zhao Chen, Jiang-Wei Chen, Shan-Hu Huang, Zhi-Li Liu
BACKGROUND: Scoliosis surgery is usually associated with large volume of intraoperative blood loss and cell salvage is commonly used to filter and retranfusion autologous blood to patients. However, the efficacy of using cell salvage in scoliosis surgery is still controversial. OBJECTIVE: The purpose of this study is to make clear that intraoperative use of cell salvage is effective to decrease the volume of perioperative allogenic blood transfusion in scoliosis surgery...
February 23, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28238682/association-between-dietary-pattern-and-cardiometabolic-risk-in-children-and-adolescents-a-systematic-review
#11
REVIEW
Naruna Pereira Rocha, Luana Cupertino Milagres, Giana Zarbato Longo, Andréia Queiroz Ribeiro, Juliana Farias de Novaes
OBJECTIVE: To evaluate the association between dietary patterns and cardiometabolic risk factors in children and adolescents. DATA SOURCE: This article followed the recommendations of PRISMA, which aims to guide review publications in the health area. The article search strategy included searches in the electronic databases MEDLINE via PubMed, Scopus, and LILACS. There was no date limitation for publications. The descriptors were used in English according to MeSH and in Portuguese according to DeCS...
February 23, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28238607/leydig-cell-hyperplasia-in-children-case-series-and-review
#12
REVIEW
Nicole Mennie, Sebastian K King, Mohan Marulaiah, Peter Ferguson, Yves Heloury, Chris Kimber
INTRODUCTION: Leydig cell hyperplasia (LCH) and Leydig cell tumours (LCTs) in children are rare, typically presenting with precocious puberty. Previously, orchidectomy was the routine management; however, more recently, testis-sparing surgery has been performed with good results. We present a series of unusual presentations of LCH, raising new management questions, and a review of the literature regarding LCH and LCT in children. STUDY DESIGN: We performed a literature search using Ovid Medline, PubMed, and Google Scholar, producing 456 articles...
February 10, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28238400/survival-of-directly-placed-ormocer-based-restorative-materials-a-systematic-review-and-meta-analysis-of-clinical-trials
#13
Paul Monsarrat, Sarah Garnier, Jean-Noel Vergnes, Karim Nasr, Brigitte Grosgogeat, Sabine Joniot
OBJECTIVES: In-vitro experiments on ormocers (ORganically MOdified CERamics) have provided controversial results. Consequently, the objectives of this meta-analysis were to (1) compare clinical performances of first generation ormocers versus conventional composite restorations, (2) explore the influence of various clinical factors and the impact of the quality of studies on published results. METHODS: The following databases were explored until 2017/01/08: Ovid MEDLINE In-Process, Pubmed, CENTRAL, HTA, DARE, LILACS and Google Scholar...
February 18, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28238350/pre-cardiac-transplant-amiodarone-use-is-not-associated-with-postoperative-mortality-an-updated-meta-analysis
#14
Douglas L Jennings, William L Baker
BACKGROUND: Amiodarone remains the preferred agent for the treatment and prevention of life-threatening ventricular arrhythmias in patients with end-stage heart failure. While several reports suggest that pre-operative amiodarone exposure worsens outcomes in heart transplant recipients, other studies have failed to validate this relationship. We sought to clarify this issue by performing a meta-analysis of the available literature surrounding this topic. METHODS: We searched Medline, SCOPUS and the Cochrane Central Register of Controlled Trials through December 15th 2016, as well as proceedings from related conferences over the prior 3years...
February 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28238228/is-sedentary-behaviour-unhealthy-and-if-so-does-reducing-it-improve-this
#15
REVIEW
Shao-Hua Chin, Chanaka Kahathuduwa, Martin Binks
PURPOSE: To provide a qualitative synthesis of the available literature on the role of sedentary behavior in health. AIMS: We sought to determine if (i) being sedentary 'causes' health problems and (ii) interventions to reduce sedentary behavior improve health status. METHODS: PubMed and Google Scholar databases were utilized. Manuscripts published from 2001 to 2015 using specific keyword combinations (eg sedentary behavior, physical activity, sitting, intervention) were included and qualitatively reviewed...
February 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28238198/the-social-historical-and-institutional-contingencies-of-dam-removal
#16
F J Magilligan, C S Sneddon, C A Fox
Environmental managers in the United States and elsewhere are increasingly perceiving dam removal as a critical tool for river restoration and enhancing watershed resilience. In New England, over 125 dams have been dismantled for ecological and economic rationales. A surprising number of these removals, including many that are ongoing, have generated heated conflicts between restoration proponents and local communities who value their dammed landscapes. Using a comparative case study approach, we examine the environmental conflict around efforts to remove six dams in New England...
February 25, 2017: Environmental Management
https://www.readbyqxmd.com/read/28238148/long-term-cancer-control-outcomes-of-robot-assisted-radical-prostatectomy-for-prostate-cancer-treatment-a-meta-analysis
#17
Lei Wang, Baojun Wang, Qing Ai, Yu Zhang, Xiangjun Lv, Hongzhao Li, Xin Ma, Xu Zhang
PURPOSE: Robot-assisted radical prostatectomy (RARP) provides significant advantages in short-term oncological outcomes for prostate cancer patients. However, data regarding the long-term cancer control outcomes of RARP are limited and inconsistent. This study aimed to evaluate these long-term outcomes. METHODS: Medline, Scopus, and other databases were searched for studies published from January 2010 to July 2016. Case series and prospective cohort studies on the long-term cancer control outcomes of patients who underwent RARP were subjected to meta-analyses by using the R statistical software...
February 25, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28238125/post-marketing-regulation-of-medicines-withdrawn-from-the-market-because-of-drug-attributed-deaths-an-analysis-of-justification
#18
Igho J Onakpoya, Carl J Heneghan, Jeffrey K Aronson
INTRODUCTION: Several medicinal products have been withdrawn from the market because of drug-attributed deaths. However, there has been no investigation of whether such withdrawals were justified, and the extent to which confirmatory studies are used to investigate drug-adverse event relationships when deaths are reported is uncertain. We documented medicinal products withdrawn from the market because of drug-attributed deaths, identified confirmatory studies investigating the drug-adverse event relationships, examined whether withdrawals of medicinal products because of drug-attributed deaths after marketing were justified based on a mechanistic analysis, and examined the trends over time...
February 25, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28238103/association-between-overweight-obesity-and-periodontal-disease-in-children-and-adolescents-a-systematic-review-and-meta-analysis
#19
REVIEW
L Martens, S De Smet, M Y P M Yusof, S Rajasekharan
AIM: To provide a systematic review and meta-analyses investigating the association between overweight/obesity as defined by Body Mass Index (BMI) and periodontal disease in terms of clinical periodontal outcomes. MATERIALS AND METHODS: A systematic search of the literature was conducted by two authors (SR and SD) independently in the Cochrane Library, PubMed, Web of Science (ISI), Scopus, Scielo, Lilacs and System for Information on Grey Literature in Europe (SIGLE) for full articles published until September 2015...
February 25, 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28237963/inappropriate-prescribing-among-older-persons-in-primary-care-protocol-for-systematic-review-and-meta-analysis-of-observational-studies
#20
Cia Sin Lee, Tau Ming Liew
INTRODUCTION: Inappropriate prescribing has a significant impact on older persons in primary care. Previous reviews on inappropriate prescribing included a heterogeneous range of populations and may not be generalisable to primary care. In this study we aim to conduct a comprehensive systematic review and meta-analysis of the prevalence, risk factors and adverse outcome associated with inappropriate prescribing, specifically among older persons in primary care. METHODS AND ANALYSIS: We will search PubMed, Embase, CINAHL, Web of Science, Scopus, PsycINFO and references of other review articles for observational studies related to the keywords 'older persons', 'primary care' and 'inappropriate prescribing'...
February 24, 2017: BMJ Open
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