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https://www.readbyqxmd.com/read/28340222/success-in-implementation-of-a-resident-in-service-examination-review-series
#1
Jessica A Forcucci, J Madison Hyer, Evelyn T Bruner, David N Lewin, Nicholas I Batalis
Objectives: Primary pathology board certification has been correlated with senior resident in-service examination (RISE) performance. We describe our success with an annual, month-long review series. Methods: Aggregate program RISE performance data were gathered for 3 years prior to and 3 years following initiation of the review series. In addition, mean United States Medical Licensing Examination Step 1 and 2 Clinical Knowledge scores for residents participating in each RISE examination were obtained to control for incoming knowledge and test-taking ability...
March 18, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28335858/netting-novel-regulators-of-hematopoiesis-and-hematologic-malignancies-in-zebrafish
#2
Wanda Kwan, Trista E North
Zebrafish are one of the preeminent model systems for the study of blood development (hematopoiesis), hematopoietic stem and progenitor cell (HSPC) biology, and hematopathology. The zebrafish hematopoietic system shares strong similarities in functional populations, genetic regulators, and niche interactions with its mammalian counterparts. These evolutionarily conserved characteristics, together with emerging technologies in live imaging, compound screening, and genetic manipulation, have been employed to successfully identify and interrogate novel regulatory mechanisms and molecular pathways that guide hematopoiesis...
2017: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/28273192/-primary-central-nervous-system-lymphoma-pathogenesis-and-histomorphology
#3
Gábor Méhes
Lymphoproliferative diseases of the central nervous system are rare, diagnostics and treatment are accordingly challenging. Since the introduction of the 2008 WHO lymphoma classification, primary CNS DLBCL - also covering the associated primary ocular (vitreoretinal) lymphoma - is a separate entity. The special localization is related with a series of newly recognized genetic, genomic and immunologic features directing to the strong interaction between transformed lymphoma cells, neural tissue components and the local immune response...
March 8, 2017: Magyar Onkologia
https://www.readbyqxmd.com/read/28225303/initial-diagnostic-workup-of-acute-leukemia-guideline-from-the-college-of-american-pathologists-and-the-american-society-of-hematology
#4
Daniel A Arber, Michael J Borowitz, Melissa Cessna, Joan Etzell, Kathryn Foucar, Robert P Hasserjian, J Douglas Rizzo, Karl Theil, Sa A Wang, Anthony T Smith, R Bryan Rumble, Nicole E Thomas, James W Vardiman
CONTEXT: -A complete diagnosis of acute leukemia requires knowledge of clinical information combined with morphologic evaluation, immunophenotyping and karyotype analysis, and often, molecular genetic testing. Although many aspects of the workup for acute leukemia are well accepted, few guidelines have addressed the different aspects of the diagnostic evaluation of samples from patients suspected to have acute leukemia. OBJECTIVE: -To develop a guideline for treating physicians and pathologists involved in the diagnostic and prognostic evaluation of new acute leukemia samples, including acute lymphoblastic leukemia, acute myeloid leukemia, and acute leukemias of ambiguous lineage...
February 22, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28134894/hematopathology
#5
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28134884/hematopathology
#6
(no author information available yet)
No abstract text is available yet for this article.
February 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28091731/book-review-hematopathology-2nd-edition
#7
Stefano A Pileri
No abstract text is available yet for this article.
January 16, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27959631/the-microscope-as-a-tool-for-disease-discovery-a-personal-voyage
#8
Elaine S Jaffe
This review reflects the trajectory of my career in hematopathology, and my personal reflections on scientific advances in the field. During the course of more than 40 years, the approach to classification of hematological malignancies has evolved from descriptive approaches, based on either cytological or clinical features, to a modern approach, which incorporates cutting-edge technologies. My philosophy has focused on defining individual diseases, an approach that can best lead to an understanding of molecular pathogenesis...
January 24, 2017: Annual Review of Pathology
https://www.readbyqxmd.com/read/27956371/discrepancies-in-lymphoma-diagnosis-over-the-years-a-13-year-experience-in-a-tertiary-center
#9
Neval Özkaya, Nuray Bassullu, Ahu Senem Demiroz, Nukhet Tüzüner
In the past accurate diagnosis of lymphoma was challenging since there were multiple competing classification systems which caused confusion and debate. After the World Health Organization lymphoma classification lymphomas still remain a diagnostic challenge among general pathologists. Purpose of this study was to examine whether the discordance among centers has declined throughout the years. All lymphoma or lymphoma suspected specimens,that had been referred to the Cerrahpasa Medical Faculty between 2000-2013 for a second opinion were deemed eligible...
December 12, 2016: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/27864296/a-mechanistic-investigation-of-thrombotic-microangiopathy-associated-with-iv-abuse-of-opana-er
#10
Ryan Hunt, Ayla Yalamanoglu, James Tumlin, Tal Schiller, Jin Hyen Baek, Andrew Wu, Agnes B Fogo, Haichun Yang, Edward Wong, Peter Miller, Paul W Buehler, Chava Kimchi-Sarfaty
Since 2012, a number of case reports have described the occurrence of thrombotic microangiopathy (TMA) following IV abuse of extended-release oxymorphone hydrochloride (Opana ER), an oral opioid for long-term treatment of chronic pain. Here, we present unique clinical features of 3 patients and investigate IV exposure to the tablet's inert ingredients as a possible causal mechanism. Guinea pigs were used as an animal model to understand the hematopathologic and nephrotoxic potential of the inert ingredient mixture (termed here as PEO+) which primarily contains high-molecular-weight polyethylene oxide (HMW PEO)...
February 16, 2017: Blood
https://www.readbyqxmd.com/read/27725143/analysis-of-hematopathology-and-alteration-of-jak1-stat3-stat5-signaling-axis-in-experimental-myelodysplastic-syndrome
#11
Suchismita Daw, Ritam Chatterjee, Aditya Law, Sujata Law
Hematological disorders like myelodysplastic syndrome (MDS) may arise due to cumulative dysregulation of various signalling pathways controlling proliferation, differentiation, maturation and apoptosis of bone marrow cells. This devastating bone marrow condition can be due to consequential abnormalities in haematopoiesis as well as its supportive microenvironment. Although mutations related to JAK/STAT pathway are common in myeloproliferative neoplasms, further studies are required to fully explore the myelodysplastic scenario regarding the concerned pathway...
December 25, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27721294/primary-plasma-cell-leukemia-a-report-of-two-cases-of-a-rare-and-aggressive-variant-of-plasma-cell-myeloma-with-the-review-of-literature
#12
REVIEW
Prithal Gangadhar, Zulfikar Ahmed, Muktha R Pai, I Sandhya
Plasma cell leukemia (PCL) is a rare and aggressive variant of myeloma accounting for 2-3% of all plasma cell dyscrasias characterized by the presence of circulating plasma cells. The diagnosis is based on the % (≥20%) and absolute number (≥2x10 9 /L) of plasma cells in the peripheral blood. The incidence of primary PCL (pPCL) is very rare and reported to occur in <1 in a million. It is classified as either pPCL occurring at diagnosis or as secondary PCL in patients with relapsed/refractory myeloma. pPCL is a distinct clinicopathological entity with different cytogenetic and molecular findings...
October 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/27613301/-report-on-the-meeting-of-the-hematopathology-working-group
#13
F Fend
No abstract text is available yet for this article.
November 2016: Der Pathologe
https://www.readbyqxmd.com/read/27438095/characteristics-of-lymphoproliferative-disorders-with-more-than-one-aberrant-cell-population-as-detected-by-10-color-flow-cytometry
#14
Talal Mahdi, Amr Rajab, Ruth Padmore, Anna Porwit
BACKGROUND: We have evaluated the frequency of lymphoproliferative disorders with more than one aberrant population of monotypic B-cells detected during routine hematopathological diagnostics. MATERIALS AND METHODS: 2600 samples peripheral (blood, bone marrow, fine needle aspirate, lymph node and pleural fluid cell suspensions) were analyzed using a ten-color B-cell panel and a ten-color T-cell panel. A ten-color plasma cell/lymphoplasmacytic panel was performed when appropriate...
July 20, 2016: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/27357289/does-taking-the-fellowship-in-service-hematopathology-examination-and-performance-relate-to-success-on-the-american-board-of-pathology-hematology-examination
#15
Sara A Monaghan, Raymond E Felgar, Melissa A Kelly, Asma M Ali, John Anastasi, Aarti P Bellara, Henry M Rinder, Rachel L Sargent, Jay Wagner, Steven H Swerdlow, Rebecca L Johnson
OBJECTIVES: The biannual Fellow In-Service Hematopathology Examination (FISHE) assesses knowledge in five content areas. We examined the relationship between taking the FISHE and performance on it with outcomes on the first attempted American Board of Pathology Hematology subspecialty certifying examination (ABP-HE). METHODS: The pass rate between the ABP-HE candidates who took the spring FISHE and those who did not were compared. The likelihood of fellows passing the ABP-HE based on their percentiles on the FISHE was also assessed...
July 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27208429/issues-in-diagnosis-of-small-b-cell-lymphoid-neoplasms-involving-the-bone-marrow-and-peripheral-blood-report-on-the-bone-marrow-workshop-of-the-xviith-meeting-of-the-european-association-for-haematopathology-and-the-society-for-hematopathology
#16
Anna Porwit, Falko Fend, Marcus Kremer, Attilio Orazi, Mükerrem Safali, Jon van der Walt
Small B cell lymphoid neoplasms are the most common lymphoproliferative disorders involving peripheral blood (PB) and bone marrow (BM). The Bone Marrow Workshop (BMW) organized by the European Bone Marrow Working Group (EBMWG) of the European Association for Haematopathology (EAHP) during the XVIIth EAHP Meeting in Istanbul, October 2014, was dedicated to discussion of cases illustrating how the recent advances in immunophenotyping, molecular techniques and cytogenetics provide better understanding and classification of these entities...
September 2016: Histopathology
https://www.readbyqxmd.com/read/27047158/hematocrit-alterations-and-its-effects-in-naturally-infected-indigenous-cattle-breeds-due-to-trypanosoma-spp-on-the-adamawa-plateau-cameroon
#17
A Mamoudou, V K Payne, S L Sevidzem
AIM: An experimental study was carried out on 148 naturally infected indigenous cattle breeds with either single or mix infections of various species of trypanosomes. The objectives of this study were to determine the species of trypanosomes, observe their hematopathological consequences on host-related risk factors and to determine the packed cell volume (PCV) of the infected group. MATERIALS AND METHODS: The buffy coat method (BCM) which is a variant of the hematocrit centrifugation method was used for the parasitological and hematological analysis...
June 2015: Veterinary World
https://www.readbyqxmd.com/read/27029036/routine-clinical-mutation-profiling-using-next-generation-sequencing-and-a-customized-gene-panel-improves-diagnostic-precision-in-myeloid-neoplasms
#18
Stephan Bartels, Elisa Schipper, Britta Hasemeier, Hans Kreipe, Ulrich Lehmann
Microscopic examination of myelodysplastic syndromes (MDS) and myelodysplastic-myeloproliferative neoplasms (MDS/MPN) may be challenging because morphological features can overlap with those of reactive states. Demonstration of clonal hematopoiesis provides a diagnostic clue and has become possible by comprehensive mutation profiling of a number of frequently mutated genes, some of them with large coding regions.To emphasize the potential benefit of NGS in hematopathology we present sequencing results from routinely processed formalin-fixed and paraffin-embedded (FFPE) bone marrow trephines (n = 192)...
May 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/26984510/the-relevance-of-tissue-thiol-histochemistry-to-diagnostic-hematopathology
#19
S W Aesif, I Kuipers, L DePalma
Expression analyses suggest that alterations of the antioxidant state of some diffuse large B-cell lymphomas can assist prognosis; reversibly oxidized thiols may serve as a surrogate marker for identifying such cases. Little is known about the distribution of free thiols and reversibly oxidized thiols in human tissues. We developed a staining technique that enables visualization of tissue thiols in situ using bright field microscopy and validated it using gastrointestinal tissue specimens. We used our thiol staining technique to assess benign tonsillectomy and diffuse large B-cell lymphoma specimens...
2016: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/26940264/laboratory-test-utilization-management-general-principles-and-applications-in-hematopathology
#20
REVIEW
Kaaren K Reichard, Adam J Wood
As the cost of health care continues to rise and reimbursement rates decrease, there is a growing demand and need to cut overall costs, enhance quality of services, and maintain as a top priority the needs and safety of the patient. In this article, we provide an introduction to test utilization and outline a general approach to creating an efficient, cost-effective test utilization strategy. We also present and discuss 2 test utilization algorithms that are evidence-based and may be of clinical utility as we move toward the future of doing the necessary tests at the right time...
March 2016: Surgical Pathology Clinics
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