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Ryan Hunt, Ayla Yalamanoglu, James Tumlin, Tal Schiller, Jin Hyen Baek, Andrew Wu, Agnes B Fogo, Haichun Yang, Edward Wong, Peter Miller, Paul W Buehler, Chava Kimchi-Sarfaty
Since 2012, a number of case reports have described the occurrence of thrombotic microangiopathy (TMA) following intravenous abuse of extended release oxymorphone hydrochloride (Opana ER), an oral opioid for long-term treatment of chronic pain. Here, we present unique clinical features of three patients and investigate intravenous exposure to the tablet's inert ingredients as a possible causal mechanism. Guinea pigs were used as an animal model to understand the hematopathologic and nephrotoxic potential of the inert ingredient mixture (termed here as PEO+) which primarily contains high molecular weight polyethylene oxide (HMW PEO)...
November 18, 2016: Blood
Suchismita Daw, Ritam Chatterjee, Aditya Law, Sujata Law
Hematological disorders like myelodysplastic syndrome (MDS) may arise due to cumulative dysregulation of various signalling pathways controlling proliferation, differentiation, maturation and apoptosis of bone marrow cells. This devastating bone marrow condition can be due to consequential abnormalities in haematopoiesis as well as its supportive microenvironment. Although mutations related to JAK/STAT pathway are common in myeloproliferative neoplasms, further studies are required to fully explore the myelodysplastic scenario regarding the concerned pathway...
October 8, 2016: Chemico-biological Interactions
Prithal Gangadhar, Zulfikar Ahmed, Muktha R Pai, I Sandhya
Plasma cell leukemia (PCL) is a rare and aggressive variant of myeloma accounting for 2-3% of all plasma cell dyscrasias characterized by the presence of circulating plasma cells. The diagnosis is based on the % (≥20%) and absolute number (≥2x10 9 /L) of plasma cells in the peripheral blood. The incidence of primary PCL (pPCL) is very rare and reported to occur in <1 in a million. It is classified as either pPCL occurring at diagnosis or as secondary PCL in patients with relapsed/refractory myeloma. pPCL is a distinct clinicopathological entity with different cytogenetic and molecular findings...
October 2016: Indian Journal of Pathology & Microbiology
F Fend
No abstract text is available yet for this article.
September 9, 2016: Der Pathologe
Talal Mahdi, Amr Rajab, Ruth Padmore, Anna Porwit
BACKGROUND: We have evaluated the frequency of lymphoproliferative disorders with more than one aberrant population of monotypic B-cells detected during routine hematopathological diagnostics. MATERIALS AND METHODS: 2600 samples peripheral (blood, bone marrow, fine needle aspirate, lymph node and pleural fluid cell suspensions) were analyzed using a ten-color B-cell panel and a ten-color T-cell panel. A ten-color plasma cell/lymphoplasmacytic panel was performed when appropriate...
July 20, 2016: Cytometry. Part B, Clinical Cytometry
Sara A Monaghan, Raymond E Felgar, Melissa A Kelly, Asma M Ali, John Anastasi, Aarti P Bellara, Henry M Rinder, Rachel L Sargent, Jay Wagner, Steven H Swerdlow, Rebecca L Johnson
OBJECTIVES: The biannual Fellow In-Service Hematopathology Examination (FISHE) assesses knowledge in five content areas. We examined the relationship between taking the FISHE and performance on it with outcomes on the first attempted American Board of Pathology Hematology subspecialty certifying examination (ABP-HE). METHODS: The pass rate between the ABP-HE candidates who took the spring FISHE and those who did not were compared. The likelihood of fellows passing the ABP-HE based on their percentiles on the FISHE was also assessed...
July 2016: American Journal of Clinical Pathology
Anna Porwit, Falko Fend, Marcus Kremer, Attilio Orazi, Mükerrem Safali, Jon van der Walt
Small B cell lymphoid neoplasms are the most common lymphoproliferative disorders involving peripheral blood (PB) and bone marrow (BM). The Bone Marrow Workshop (BMW) organized by the European Bone Marrow Working Group (EBMWG) of the European Association for Haematopathology (EAHP) during the XVIIth EAHP Meeting in Istanbul, October 2014, was dedicated to discussion of cases illustrating how the recent advances in immunophenotyping, molecular techniques and cytogenetics provide better understanding and classification of these entities...
September 2016: Histopathology
A Mamoudou, V K Payne, S L Sevidzem
AIM: An experimental study was carried out on 148 naturally infected indigenous cattle breeds with either single or mix infections of various species of trypanosomes. The objectives of this study were to determine the species of trypanosomes, observe their hematopathological consequences on host-related risk factors and to determine the packed cell volume (PCV) of the infected group. MATERIALS AND METHODS: The buffy coat method (BCM) which is a variant of the hematocrit centrifugation method was used for the parasitological and hematological analysis...
June 2015: Veterinary World
Stephan Bartels, Elisa Schipper, Britta Hasemeier, Hans Kreipe, Ulrich Lehmann
Microscopic examination of myelodysplastic syndromes (MDS) and myelodysplastic-myeloproliferative neoplasms (MDS/MPN) may be challenging because morphological features can overlap with those of reactive states. Demonstration of clonal hematopoiesis provides a diagnostic clue and has become possible by comprehensive mutation profiling of a number of frequently mutated genes, some of them with large coding regions.To emphasize the potential benefit of NGS in hematopathology we present sequencing results from routinely processed formalin-fixed and paraffin-embedded (FFPE) bone marrow trephines (n = 192)...
May 24, 2016: Oncotarget
S W Aesif, I Kuipers, L DePalma
Expression analyses suggest that alterations of the antioxidant state of some diffuse large B-cell lymphomas can assist prognosis; reversibly oxidized thiols may serve as a surrogate marker for identifying such cases. Little is known about the distribution of free thiols and reversibly oxidized thiols in human tissues. We developed a staining technique that enables visualization of tissue thiols in situ using bright field microscopy and validated it using gastrointestinal tissue specimens. We used our thiol staining technique to assess benign tonsillectomy and diffuse large B-cell lymphoma specimens...
2016: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
Kaaren K Reichard, Adam J Wood
As the cost of health care continues to rise and reimbursement rates decrease, there is a growing demand and need to cut overall costs, enhance quality of services, and maintain as a top priority the needs and safety of the patient. In this article, we provide an introduction to test utilization and outline a general approach to creating an efficient, cost-effective test utilization strategy. We also present and discuss 2 test utilization algorithms that are evidence-based and may be of clinical utility as we move toward the future of doing the necessary tests at the right time...
March 2016: Surgical Pathology Clinics
Cordelia Sever, Charles L Abbott, Monica E de Baca, Joseph D Khoury, Sherrie L Perkins, Kaaren Kemp Reichard, Ann Taylor, Howard R Terebelo, Carol Colasacco, R Bryan Rumble, Nicole E Thomas
CONTEXT: -There is ample evidence from the solid tumor literature that synoptic reporting improves accuracy and completeness of relevant data. No evidence-based guidelines currently exist for synoptic reporting for bone marrow samples. OBJECTIVE: -To develop evidence-based recommendations to standardize the basic components of a synoptic report template for bone marrow samples. DESIGN: -The College of American Pathologists Pathology and Laboratory Quality Center convened a panel of experts in hematopathology to develop recommendations...
September 2016: Archives of Pathology & Laboratory Medicine
(no author information available yet)
No abstract text is available yet for this article.
February 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
(no author information available yet)
No abstract text is available yet for this article.
February 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
Lori Soma, Vivian G Oehler, Cheng Ding, Sindhu Cherian
BACKGROUND: The 2008 WHO is not specific regarding subclassification of chronic myelogenous leukemia (CML) with less than 20% abnormal B lymphoid blasts (ABLB), and suggests patients with ABLB often show rapid progression (Swerdlow, 2008). Recent studies have shown variable outcomes when small abnormal B cell populations are seen by flow cytometry (El Rassi et al., Cancer 2015; 121:872-875; Vrotsos et al., Cytometry B Clin Cytom 2015). METHODS: The hematopathology database was searched (7...
September 2016: Cytometry. Part B, Clinical Cytometry
P Möller
No abstract text is available yet for this article.
November 2015: Der Pathologe
Sindhu Cherian, Vivian McCullouch, Valerie Miller, Katy Dougherty, Jonathan R Fromm, Brent L Wood
BACKGROUND: Systemic mastocytosis (SM) is a diagnosis made using clinical, laboratory, and histologic parameters. Aberrant CD2 and/or CD25 expression on mast cells provides one minor criterion for a diagnosis of SM. To validate a tube (CD45/CD117/CD2/CD25) for mast cell evaluation, flow cytometry (FC) on residual material from marrow aspirates samples submitted to the hematopathology laboratory was performed. METHODS: Samples evaluated (n = 98) had no clinical or morphologic suspicion for SM...
July 2016: Cytometry. Part B, Clinical Cytometry
Leticia Quintanilla-Martinez, Birgitta Sander, John K C Chan, Luc Xerri, German Ott, Elias Campo, Steven H Swerdlow
Indolent lymphomas in the pediatric population were discussed during the 2014 European Association for Haematopathology/Society of Hematopathology workshop in Istanbul, Turkey. This session was focused on pediatric-type follicular lymphoma (FL), and its differential diagnosis with the newly recognized entity of IRF4/MUM1+ lymphomas mainly involving Waldeyer's ring. The differential diagnosis between t(14;18) negative FL grade 1/2 and pediatric-type FL in adults was highlighted. The overlapping pathological and clinical features between FL and nodal marginal zone lymphoma (NMZL) in children and young adults were recognized and morphologic and immunophenotypical criteria helpful for the differential diagnosis were presented...
February 2016: Virchows Archiv: An International Journal of Pathology
Leonardo Boiocchi, Umberto Gianelli, Alessandra Iurlo, Falko Fend, Irina Bonzheim, Daniele Cattaneo, Daniel M Knowles, Attilio Orazi
Polycythemia vera in 20-30% of cases progresses towards post-polycythemic myelofibrosis, an advanced phase characterized by decreased red blood cells counts and increasing splenomegaly with extramedullary hematopoiesis. There is evidence that the presence of neutrophilic leukocytosis at polycythemia vera disease outset is associated with an increased risk of recurrent thrombosis. However, its clinical significance when developing later in the course of the disease is not well defined. Over a period of 8 years we identified from the files of two reference centers 10 patients (7M/3F, median age: 68 years) who developed persistent absolute leukocytosis ≥ 13 × 10⁹/l (median: 25...
November 2015: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Birgitta Sander, Leticia Quintanilla-Martinez, German Ott, Luc Xerri, Isinsu Kuzu, John K C Chan, Steven H Swerdlow, Elias Campo
Mantle cell lymphoma (MCL) is a distinctive lymphoma type generally characterized by the presence of CCND1 translocation and overexpression of cyclin D1. MCL usually presents with advanced stage and rapid clinical progression. The diagnosis is in most instances uncomplicated but cases with variant morphologies or immunophenotypes, especially cyclin D1-negative cases, may cause diagnostic difficulties. During the mantle cell lymphoma (MCL) session at the European Association of Haematopathology/Society for Hematopathology workshop 2014 held in Istanbul, Turkey, submitted cases illustrated interesting features such as unusual morphology or immunophenotypes...
March 2016: Virchows Archiv: An International Journal of Pathology
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