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https://www.readbyqxmd.com/read/28534431/ameliorating-effect-of-anti-alzheimer-s-drugs-on-the-bidirectional-association-between-type-2-diabetes-mellitus-and-alzheimer-s-disease
#1
Amira S Ahmed, Rehab M Elgharabawy, Amal H Al-Najjar
Mild to severe forms of nervous system damage were exhibited by approximately 60-70% of diabetics. It is important to understand the association between type 2 diabetes mellitus and Alzheimer's disease. The aim of the present work is to understand the bidirectional association between type 2 diabetes and Alzheimer's disease pathogenesis, that was monitored by glycaemic status, lipid profile, amyloid beta 40 and 42 (Aβ40 and Aβ42), C-reactive protein, total creatine kinase, total lactate dehydrogenase, D-dimer and magnesium measurements, to assess the association between theses biochemical markers and each other, to estimate the possibility of utilizing the amyloid beta as biochemical marker of T2D in Alzheimer's patients, and to evaluate the effect of piracetam and memantine drugs on diabetes mellitus...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28514338/-a-comparative-chemoreactome-analysis-of-mexidol
#2
I Yu Torshin, O A Gromova, I S Sardaryan, L E Fedotova
AIM: To compare mexidol with control molecules (choline alfoscerate, piracetam, glycine, semax) using chemoreactome analysis. MATERIAL AND METHODS: The chemical structure of mexidol was compared to molecule metabolites extracted from the Human Metabolome Database (HMDB) and a drug database. More than 40 000 of metabolites from HMDB were used as a model of human metabolome. RESULTS AND CONCLUSION: The chemoreactome analysis showed that mexidol may be (1) an agonist of acetylcholine and GABA-A receptors; (2) an anti-inflammatory agent, the effects of which are carried out by inhibiting the synthesis of pro-inflammatory prostaglandins; (3) a neurotrophic agent with neuroprotective properties; (4) a coagulation inhibitor; (5) a diabetes medication and (6) a hypolipidemic agent...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28388810/hemilability-driven-water-activation-a-ni-ii-catalyst-for-base-free-hydration-of-nitriles-to-amides
#3
Jitendra K Bera, Kuldeep Singh, Abir Sarbajna, Indranil Dutta, Pragati Pandey
A Ni(II) complex 1 containing pyridyl- and hydroxy-functionalized N-heterocyclic carbenes (NHC) is synthesized and its catalytic utility for selective nitrile hydration to amide under base-free condition is evaluated. The title compound exploits hemilabile pyridyl unit to interact with a catalytically relevant water molecule via hydrogen-bonding and promote nucleophilic water attack to the nitrile. A wide variety of nitriles are hydrated to the corresponding amides including pharmaceutical drugs Rufinamide, Rifater and Piracetam...
April 7, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28363525/protective-effect-of-a-phenolic-extract-containing-indoline-amides-from-portulaca-oleracea-against-cognitive-impairment-in-senescent-mice-induced-by-large-dose-of-d-galactose-nano2
#4
Peipei Wang, Hongxiang Sun, Dianyu Liu, Zezhao Jiao, Su Yue, Xiuquan He, Wen Xia, Jianbo Ji, Lan Xiang
ETHNOPHARMACOLOGICAL RELEVANCE: Portulaca oleracea L. is a potherb and also a widely used traditional Chinese medicine. In accordance with its nickname "longevity vegetable", pharmacological study demonstrated that this plant possessed antioxidant, anti-aging, and cognition-improvement function. Active principles pertaining to these functions of P. oleracea need to be elucidated. AIM OF THE STUDY: The present study evaluated the effect of a phenolic extract (PAAs) from P...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28176051/piracetam-attenuates-lps-induced-neuroinflammation-and-cognitive-impairment-in-rats
#5
Alok Tripathi, Pankaj Paliwal, Sairam Krishnamurthy
The present study was performed to investigate the effect of piracetam on neuroinflammation induced by lipopolysaccharide (LPS) and resulting changes in cognitive behavior. Neuroinflammation was induced by a single dose of LPS solution infused into each of the lateral cerebral ventricles in concentrations of 1 μg/μl, at a rate of 1 μl/min over a 5-min period, with a 5-min waiting period between the two infusions. Piracetam in doses of 50, 100, and 200 mg/kg i.p. was administered 30 min before LPS infusion and continued for 9 days...
February 7, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28122287/the-fluorescence-and-resonance-rayleigh-scattering-spectra-study-on-the-interactions-of-palladium-ii-nootropic-chelate-with-congo-red-and-their-analytical-applications
#6
Fang Chen, Jingdong Peng, Shaopu Liu, Huanjun Peng, Ziyu Pan, Lingli Bu, Huan Xiao, Ruiwen Zhang
A highly sensitive detection approach of resonance Rayleigh scattering spectra (RRS) is firstly applied to analyzing nootropic drugs including piracetam (PIR) and oxiracetam (OXI). In HCl-NaAc buffer solution (pH=3.0), the OXI chelated with palladium (II) to form the chelate cation [Pd2·OXI](2+), and then reacted with Congo red (CGR) by virtue of electrostatic attraction and hydrophobic force to form binary complex [Pd2·OXI]. CGR2, which could result in the great enhancement of RRS. The resonance Rayleigh scattering signal was recorded at λex=λem=375nm...
April 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27915006/predicting-optimal-wet-granulation-parameters-for-extrusion-spheronisation-of-pharmaceutical-pellets-using-a-mixer-torque-rheometer
#7
Manuel Kuhs, John Moore, Gayathri Kollamaram, Gavin Walker, Denise Croker
Mixer torque rheometry (MTR) was evaluated as a pre-production (pre-formulation and optimization) tool for predicting ideal liquid-to-solid ratios (L/S) for extrusion-spheronisation of a wide range of APIs using 10g formulations. APIs of low, medium and high solubility were formulated at low and high loadings (15 and 40% w/w, respectively) with PVP as binder (5%) and MCC as the major excipient. L/S corresponding to the maximum torque produced during wet massing in the MTR, L/S(maxT), was 0.8 for the low solubility APIs, which decreased to 0...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27790463/comparison-between-the-effect-of-cow-ghee-and-butter-on-memory-and-lipid-profile-of-wistar-rats
#8
Yogita Surendra Karandikar, Akshata Sanjay Bansude, Eesha Ajit Angadi
INTRODUCTION: The traditional texts designate Cow Ghee as Medhya Rasayana, beneficial for mental alertness and memory. There has been concern about increased risk of cardiovascular disease due to its high percentage of saturated fatty acids in ghee. Amongst all edible fats, nutrition composition of cow ghee and butter is comparatively similar. Hence we had planned a study to assess effect of cow ghee on memory and lipid profile. AIM: So the aim of this study is to assess the effect of cow ghee on memory and lipid profile...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27747106/enhanced-neuroplasticity-by-the-metabolic-enhancer-piracetam-associated-with-improved-mitochondrial-dynamics-and-altered-permeability-transition-pore-function
#9
Carola Stockburger, Davide Miano, Thea Pallas, Kristina Friedland, Walter E Müller
The mitochondrial cascade hypothesis of dementia assumes mitochondrial dysfunction leading to reduced energy supply, impaired neuroplasticity, and finally cell death as one major pathomechanism underlying the continuum from brain aging over mild cognitive impairment to initial and advanced late onset Alzheimer's disease. Accordingly, improving mitochondrial function has become an important strategy to treat the early stages of this continuum. The metabolic enhancer piracetam has been proposed as possible prototype for those compounds by increasing impaired mitochondrial function and related aspects like mechanisms of neuroplasticity...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/27703360/delirium-as-a-complication-of-the-surgical-intensive-care
#10
Rostislav Horacek, Barbora Krnacova, Jan Prasko, Klara Latalova
BACKGROUND: The aim of this study was to examine the impact of somatic illnesses, electrolyte imbalance, red blood cell count, hypotension, and antipsychotic and opioid treatment on the duration of delirium in Central Intensive Care Unit for Surgery. PATIENTS AND METHODS: Patients who were admitted to the Department of Central Intensive Care Unit for Surgery in the University Hospital Olomouc from February 2004 to November 2008 were evaluated using Riker sedation-agitation scale...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27660276/in-vitro-effects-of-cognitives-and-nootropics-on-mitochondrial-respiration-and-monoamine-oxidase-activity
#11
Namrata Singh, Jana Hroudová, Zdeněk Fišar
Impairment of mitochondrial metabolism, particularly the electron transport chain (ETC), as well as increased oxidative stress might play a significant role in pathogenesis of Alzheimer's disease (AD). Some effects of drugs used for symptomatic AD treatment may be related to their direct action on mitochondrial function. In vitro effects of pharmacologically different cognitives (galantamine, donepezil, rivastigmine, 7-MEOTA, memantine) and nootropic drugs (latrepirdine, piracetam) were investigated on selected mitochondrial parameters: activities of ETC complexes I, II + III, and IV, citrate synthase, monoamine oxidase (MAO), oxygen consumption rate, and hydrogen peroxide production of pig brain mitochondria...
September 23, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27629998/myoclonus-and-seizures-in-progressive-myoclonus-epilepsies-pharmacology-and-therapeutic-trials
#12
REVIEW
Roberto Michelucci, Elena Pasini, Patrizia Riguzzi, Eva Andermann, Reetta Kälviäinen, Pierre Genton
Generalized motor seizures, usually tonic-clonic, tonic-vibratory, myoclonic or clonic, and stimulus-sensitive/action myoclonus are typical features of progressive myoclonus epilepsies (PMEs). Despite the introduction of many anticonvulsants, the treatment of these symptoms, particularly myoclonus, remains challenging, due to the incomplete and often transitory effects of most drugs. Moreover, treatment is only symptomatic, since therapy targeting the underlying aetiology for these genetic conditions is in its infancy...
September 1, 2016: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/27599510/neuropeptide-cycloprolylglycine-increases-the-levels-of-brain-derived-neurotrophic-factor-in-neuronal-cells
#13
T A Gudasheva, K N Koliasnikova, T A Antipova, S B Seredenin
It was shown for the first time that the endogenous cyclic dipeptide cycloprolylglycine (CPG) at concentrations of 10(-7) and 10(-3) M and piracetam at a concentration of 10(-3) M increased the content of brainderived neurotrophic factor (BDNF) in the culture of neuronal cells in normal state and under conditions of glutamate and 6-oxydopamine neurotoxicity. This may indicate the possible involvement of BDNF in the mechanism of action of neuropeptide CPG and piracetam.
July 2016: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27585927/piracetam-facilitates-the-anti-amnesic-but-not-anti-diabetic-activity-of-metformin-in-experimentally-induced-type-2-diabetic-encephalopathic-rats
#14
Shruti Pandey, Debapriya Garabadu
Piracetam exhibits anti-amnesic activity in several animal models of dementia. However, its anti-amnesic potential has yet to be evaluated in type-2 diabetes mellitus (T2DM)-induced encephalopathy. Therefore, in the present study, piracetam (25, 50 and 100 mg/kg) was screened for anti-amnesic and anti-diabetic activity in T2DM-induced encephalopathic male rats. Subsequently, anti-amnesic and anti-diabetic activities were evaluated for piracetam, metformin and their combination in T2DM-induced encephalopathic animals...
September 1, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27569579/stability-indicating-tlc-densitometric-and-hplc-methods-for-the-simultaneous-determination-of-piracetam-and-vincamine-in-the-presence-of-their-degradation-products
#15
Amal B Ahmed, Maha M Abdelrahman, Nada S Abdelwahab, Fathy M Salama
Newly established TLC-densitometric and RP-HPLC methods were developed and validated for the simultaneous determination of Piracetam (PIR) and Vincamine (VINC) in their pharmaceutical formulation and in the presence of PIR and VINC degradation products, PD and VD, respectively. The proposed TLC-densitometric method is based on the separation and quantitation of the studied components using a developing system that consists of chloroform-methanol-glacial acetic acid-triethylamine (8 + 2 + 0.1 + 0.1, v/v/v/v) on TLC silica gel 60 F254 plates, followed by densitometric scanning at 230 nm...
November 1, 2016: Journal of AOAC International
https://www.readbyqxmd.com/read/27540770/design-synthesis-and-biological-evaluation-of-selected-3-3-amino-propoxy-benzenamines-as-acetylcholinesterase-inhibitors
#16
Ruchi Malik, Richa Gupta, Shubham Srivastava, Bhanwar Singh Choudhary, Manish Sharma
The present paper describes design, synthesis, and biological evaluation of a series of some 3-[3-(amino)propoxy]benzenamines as acetylcholinesterase inhibitors using mice as a model and piracetam as a reference drug. The structures of these compounds were confirmed by spectral analysis and compounds were tested for memory enhancing activity using elevated plus maze test and acetylcholinesterase inhibitory assay. The inhibitory range of synthesized compounds was from 8.99 to 28.31 μM. The synthesized compounds possessed higher or equivalent percent retention as compared to piracetam at 1 mg/kg with no other CNS-related activities (locomotor and muscle relaxant, analgesic and anticonvulsant activities)...
August 19, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27539610/a-meta-analysis-of-the-effect-of-different-neuroprotective-drugs-in-management-of-patients-with-traumatic-brain-injury
#17
REVIEW
Iman El Sayed, Adel Zaki, Akram M Fayed, Gihan M Shehata, Sherif Abdelmonem
Traumatic brain injury is a major problem worldwide. Our objective is to synthesize available evidence in the literature concerning the effectiveness of neuroprotective drugs (cerebrolysin, citicoline, and piracetam) on Glasgow outcome score (GOS), cognitive performance, and survival in traumatic brain injury patients. Comprehensive search of electronic databases, search engines, and conferences proceedings; hand search journals; searching reference lists of relevant articles, theses, and local publications; and contact of authors for incomplete data were performed...
August 18, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27445477/effects-of-astragalus-polysaccharides-on-memory-impairment-in-a-diabetic-rat-model
#18
Changping Dun, Junqian Liu, Fucheng Qiu, Xueda Wu, Yakun Wang, Yongyan Zhao, Ping Gu
OBJECTIVE: Astragalus polysaccharides (APS) are active constituents of Astragalus membranaceus. In this study, we aimed to investigate the effects of APS on memory impairment in a diabetic rat model and their mechanisms. METHODS: A diabetic model was established in 50 male Wistar rats with streptozotocin intra-peritoneal injection. A blood glucose level higher than 16.7 mmol/L obtained 72 hours after the injection was regarded as a successful diabetic model. The modeled rats were divided into model group, high, medium, and low doses of APS, and piracetam groups (positive control)...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27416675/-studying-some-pharmacological-effects-of-new-3-hydroxypyridine-derivative
#19
V V Yasnetsov, E G Tsublova, Vic V Yasnetsov, S Ya Skachilova, S K Karsanova, Yu V Ivanov
It was established that a new 3-hydroxypyridine (3-HP) derivative, 2-ethyl-6-methyl-3-hydroxypyridine L-aspartate (3-HP), in small doses (1 and 5 mg/kg) increased physical performance in treadmill and swimming tests on rats. The new substance showed greater or equal effects compared to the reference actoprotector drugs metaprot and ladasten in much higher doses. The gluconeogenesis inhibitor tryptophan significantly (74 ± 5%, p < 0.01) prevented this stimulatory effect of 3-HPA in the treadmill test on rats...
2016: Eksperimental'naia i Klinicheskaia Farmakologiia
https://www.readbyqxmd.com/read/27408469/benign-paroxysmal-positional-vertigo-following-sinus-floor-elevation-in-patient-with-antecedents-of-vertigo
#20
Huseyin Akcay, Murat Ulu, Seyfi Kelebek, Ibrahim Aladag
Benign paroxysmal positional vertigo (BPPV) is an unfamiliar and rare complication occurring following osteotome sinus floor elevation (OSFE) and simultaneous implant placement. Etiology of this disorder is commonly displacement of otoliths by vibratory forces transmitted by osteotomes and mallet along with the hyperextension of the head during the operation, causing them to float around in the endolymph. This report presents a case of protracted BPPV following OSFE and simultaneous implant placement. A 43-year-old female suffered intense vertigo and nausea immediately after implant placement using an OSFE procedure...
July 2016: Journal of Maxillofacial and Oral Surgery
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