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https://www.readbyqxmd.com/read/28214290/evaluate-the-efficacy-and-safety-of-anti-epileptic-medications-for-partial-seizures-of-epilepsy-a-network-meta-analysis
#1
Teng Zhao, Xuemin Feng, Jingyao Liu, Jiguo Gao, Chunkui Zhou
Epilepsy is a brain and neurological disorder with high prevalence. It was reported that more than 70% of epileptic seizures were controlled by anti-epileptic medications, whereas the lack of evidence with respect to head-to-head comparisons motivated researchers to seek alternative approaches that are able to provide deep insights into the profile of anti-epileptic medications. In this study, we performed a network meta-analysis (NMA) to evaluate the efficacy and safety of anti-epileptic medications for partial seizures of epilepsy...
February 18, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28209500/theoretical-estimation-of-64-cu-production-with-neutrons-emitted-during-18-f-production-with-a-30mev-medical-cyclotron
#2
Lucrezia Auditore, Ernesto Amato, Sergio Baldari
PURPOSE: This work presents the theoretical estimation of a combined production of (18)F and (64)Cu isotopes for PET applications. (64)Cu production is induced in a secondary target by neutrons emitted during a routine (18)F production with a 30MeV cyclotron: protons are used to produce (18)F by means of the (18)O(p,n)(18)F reaction on a [(18)O]-H2O target (primary target) and the emitted neutrons are used to produce (64)Cu by means of the (64)Zn(n,p)(64)Cu reaction on enriched zinc target (secondary target)...
February 3, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28209186/identification-of-immune-protective-genes-of-eimeria-maxima-through-cdna-expression-library-screening
#3
XinChao Yang, MengHui Li, JianHua Liu, YiHong Ji, XiangRui Li, LiXin Xu, RuoFeng Yan, XiaoKai Song
BACKGROUND: Eimeria maxima is one of the most prevalent Eimeria species causing avian coccidiosis, and results in huge economic loss to the global poultry industry. Current control strategies, such as anti-coccidial medication and live vaccines have been limited because of their drawbacks. The third generation anticoccidial vaccines including the recombinant vaccines as well as DNA vaccines have been suggested as a promising alternative strategy. To date, only a few protective antigens of E...
February 16, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28208882/pbl-trigger-design-by-medical-students-an-effective-active-learning-strategy-outside-the-classroom
#4
Maya Roche, Indira Kakkunje Adiga, Akshatha G Nayak
INTRODUCTION: Problem Based Learning (PBL) is known world over as an effective, active learning strategy with many benefits for the student. Usually, in medical schools, PBL triggers are designed by a well-trained group of faculty from basic and clinical sciences. The challenge was whether this task could be given to students in the first year of their curriculum and be executed by them effectively. AIM: To enhance active learning, comprehension and critical thinking with a view to promote horizontal and vertical integration between subjects...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28203084/use-of-transcranial-direct-current-stimulation-for-the-treatment-of-auditory-hallucinations-of-schizophrenia-a-systematic-review
#5
REVIEW
Pedro H Pondé, Eduardo P de Sena, Joan A Camprodon, Arão Nogueira de Araújo, Mário F Neto, Melany DiBiasi, Abrahão Fontes Baptista, Lidia Mvr Moura, Camila Cosmo
INTRODUCTION: Auditory hallucinations are defined as experiences of auditory perceptions in the absence of a provoking external stimulus. They are the most prevalent symptoms of schizophrenia with high capacity for chronicity and refractoriness during the course of disease. The transcranial direct current stimulation (tDCS) - a safe, portable, and inexpensive neuromodulation technique - has emerged as a promising treatment for the management of auditory hallucinations. OBJECTIVE: The aim of this study is to analyze the level of evidence in the literature available for the use of tDCS as a treatment for auditory hallucinations in schizophrenia...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28202228/cross-institutional-knowledge-based-planning-kbp-implementation-and-its-performance-comparison-to-auto-planning-engine-ape
#6
Binbin Wu, Martijn Kusters, Martina Kunze-Busch, Tim Dijkema, Todd McNutt, Giuseppe Sanguineti, Karl Bzdusek, Anatoly Dritschilo, Dalong Pang
BACKGROUND AND PURPOSE: To investigate (1) whether a plan library established at one institution can be applied for another institution's knowledge-based planning (KBP); (2) the performance of cross-institutional KBP compared to Auto-Planning Engine (APE). MATERIAL AND METHODS: Radboud University Medical Center (RUMC) provided 35 oropharyngeal cancer patients (68Gy to PTV(68) and 50.3Gy to PTV(50.3)) with clinically-delivered and comparative APE plans. The Johns Hopkins University (JHU) contributed a three-dose-level plan library consisting of 179 clinically-delivered plans...
February 12, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28202008/relationship-between-abcb1-3435tt-genotype-and-antiepileptic-drugs-resistance-in-epilepsy-updated-systematic-review-and-meta-analysis
#7
Malek Chouchi, Wajih Kaabachi, Hedia Klaa, Kalthoum Tizaoui, Ilhem Ben-Youssef Turki, Lamia Hila
BACKGROUND: Antiepileptic drugs (AEDs) are effective medications available for epilepsy. However, many patients do not respond to this treatment and become resistant. Genetic polymorphisms may be involved in the variation of AEDs response. Therefore, we conducted an updated systematic review and a meta-analysis to investigate the contribution of the genetic profile on epilepsy drug resistance. METHODS: We proceeded to the selection of eligible studies related to the associations of polymorphisms with resistance to AEDs therapy in epilepsy, published from January 1980 until November 2016, using Pubmed and Cochrane Library databases...
February 15, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28201967/dipeptidyl-peptidase-4-inhibitor-induced-angioedema-an-overlooked-and-potentially-lethal-adverse-drug-reaction
#8
Susanne Irene Scott, Michelle Fog Andersen, Lise Aagaard, Christian Von Buchwald, Eva Rye Rasmussen
Introduction Angioedema is a potentially fatal adverse drug reaction of some medications, as swellings of the upper airways can cause death by asphyxiation. Angiotensin converting enzyme-inhibitors are widely known to cause angioedema but less is known about the association between dipeptidyl peptidase-4 inhibitors (gliptins) and angioedema. Dipeptidyl peptidase-4 inhibitors are anti-diabetic drugs used to improve glycaemic control. They, as a class effect, inadvertently affect the degradation of the vasoactive kinins bradykinin and substance P, both of which can cause angioedema due to vasodilatation and increase in vascular permeability in the capillaries...
February 14, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28199934/mixed-corticomedullary-adrenal-carcinoma-case-report-comparison-in-features-treatment-and-prognosis-with-the-other-two-reported-cases
#9
Mhd Belal Alsabek, Riad Alhmaidi, Bader Ghazzawi, Ghiath Hamed, Alhadi Alseoudi
INTRODUCTION: Adrenal corticomedullary adenoma was reviewed in many cases in PubMed Library, While the coincidence corticomedullary adrenal carcinoma in the same gland was just described in two cases in the medical literature. Our case is the third to be reported and was treated with surgery and adjuvant chemotherapy and followed for two years. PRESENTATION OF CASE: A 50-year-old man suffered from a mass effect in the left abdominal side. While the laboratory showed a mild elevation in the levels of both serum cortisol and 24h urine cortisol, radiological images were highly suggested an adrenal malignant tumor without metastasis...
January 31, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28198176/what-is-changing-in-the-surgical-treatment-of-gastrointestinal-stromal-tumors-after-multidisciplinary-approach-a-comprehensive-literature-s-review
#10
Belinda De Simone, Luca Ansaloni, Massimo Sartelli, Federico Coccolini, Salomone Di Saverio, Maria A Pantaleo, Maristella Saponara, Margherita Nannini, Harishine K Abongwa, Josephine A Napoli, Fausto Catena
INTRODUCTION: GIST represent the most common mesenchymal neoplasms of the gastrointestinal tract Surgery is the only curative treatment for GIST. The aim of our review is to highlight the changes in the surgical treatment of GIST after the introduction of TKI therapy in a multimodality management ( neo-adiuvant or adiuvant setting). EVIDENCE ACQUISITION: We carried out a review of the recent literature about surgical treatment of GIST according to its anatomical location and size according to PRISMA STATEMENT to systematic review...
February 14, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/28195700/discovery-and-characterization-of-a-potent-and-specific-peptide-ligand-targeting-endothelial-progenitor-cells-and-endothelial-cells-for-tissue-regeneration
#11
Dake Hao, Wenwu Xiao, Ruiwu Liu, Priyadarsini Kumar, YuanPei Li, Ping Zhou, Fuzheng Guo, Diana L Farmer, Kit S Lam, Fengshan Wang, Aijun Wang
Endothelial progenitor cells (EPCs) and endothelial cells (ECs) play a vital role in endothelialization and vascularization for tissue regeneration. Various EPC/EC targeting biomolecules have been investigated to improve tissue regeneration with limited success often due to their limited functional specificity and structural stability. One-Bead-One-Compound (OBOC) combinatorial technology is an ultra-high throughput chemical library synthesis and screening method suitable for ligand discovery against a wide range of biological targets, such as integrins...
February 14, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28194755/withdrawn-exercise-for-dysmenorrhoea
#12
REVIEW
Julie Brown, Stephen Brown
BACKGROUND: Dysmenorrhoea is characterised by cramping lower abdominal pain that may radiate to the lower back and upper thighs and is commonly associated with nausea, headache, fatigue and diarrhoea. Physical exercise has been suggested as a non-medical approach to the management of these symptoms. OBJECTIVES: To assess the evidence for the effectiveness of exercise in the treatment of dysmenorrhoea. SEARCH METHODS: A search was conducted using the methodology of the Menstrual Disorders and Subfertility Group (August 2009)...
February 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28193848/measurement-properties-of-self-report-physical-activity-assessment-tools-in-stroke-a-protocol-for-a-systematic-review
#13
Júlia Caetano Martins, Larissa Tavares Aguiar, Sylvie Nadeau, Aline Alvim Scianni, Luci Fuscaldi Teixeira-Salmela, Christina Danielli Coelho de Morais Faria
INTRODUCTION: Self-report physical activity assessment tools are commonly used for the evaluation of physical activity levels in individuals with stroke. A great variety of these tools have been developed and widely used in recent years, which justify the need to examine their measurement properties and clinical utility. Therefore, the main objectives of this systematic review are to examine the measurement properties and clinical utility of self-report measures of physical activity and discuss the strengths and limitations of the identified tools...
February 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28192737/a-systematic-review-of-yoga-for-major-depressive-disorder
#14
REVIEW
Holger Cramer, Dennis Anheyer, Romy Lauche, Gustav Dobos
BACKGROUND: The purpose of this review was to investigate the efficacy and safety of yoga interventions in treating patients with major depressive disorder. METHODS: MEDLINE, Scopus, and the Cochrane Library were screened through December 2016. Randomized controlled trials (RCTs) comparing yoga to inactive or active comparators in patients with major depressive disorder were eligible. Primary outcomes included remission rates and severity of depression. Anxiety and adverse events were secondary outcomes...
February 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28186357/short-and-long-term-outcomes-with-renin-angiotensin-aldosterone-inhibitors-in-renal-transplant-recipients-a-meta-analysis-of-randomized-controlled-trials
#15
Ruo-Xi Liao, Xia-Fei Lyu, Wen-Jiao Tang, Kai Gao
BACKGROUND: Angiotensin-convertingenzyme inhibitors (ACEIs) and angiotensin II receptor type 1 blockers (ARBs) are often prescribed for renal transplant recipients (RTRs), but the outcomes of these medications in RTRs remain controversial. METHODS: The PubMed, Embase, and Cochrane Library databases were systematically searched. Randomized controlled trials investigating the outcomes of ACEI/ARBs in RTRs were included for meta-analysis. RESULTS: Twenty-two trials with 2242 patients were identified...
February 10, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28183554/comparison-of-laryngeal-mask-airway-vs-tracheal-intubation-a-systematic-review-on-airway-complications
#16
REVIEW
Babette F van Esch, Inge Stegeman, Adriana L Smit
To determine whether the laryngeal mask airway (LMA) has advantages over the tracheal tube (TT) in terms of incidence of cough, sore throat, laryngospasm, dysphagia, dysphonia, and blood staining. This is a systematic literature review performed at the Universtity Medical Center of Utrecht. The online databases PubMed, Embase, and the Cochrane Library were searched for relevant randomized controlled trials. Two independent reviewers selected relevant articles after title, abstract, and full text screening. Articles were assessed on risk of bias in accordance with the Cochrane risk of bias tool...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28183190/online-information-seeking-behaviors-of-parents-of-children-with-adhd
#17
Adam Sage, Delesha Carpenter, Robyn Sayner, Kathleen Thomas, Larry Mann, Sandy Sulzer, Adrian Sandler, Betsy Sleath
This article describes ( a) parent questions about ADHD (attention deficit/hyperactivity disorder), ( b) parent Internet use to seek ADHD information, and ( c) associations between type of Internet access and ADHD information-seeking. Seventy parents of children (ages 7-17 years) with ADHD completed questionnaires after their child's visit with their pediatrician. Bivariate relationships were assessed using chi-square statistics, Pearson correlation coefficients, or t tests. Parents identified an average of 8...
February 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28179634/rapid-and-cost-effective-high-throughput-sequencing-for-identification-of-germline-mutations-of-brca1-and-brca2
#18
Somayeh Ahmadloo, Hirofumi Nakaoka, Takahide Hayano, Kazuyoshi Hosomichi, Hua You, Emi Utsuno, Takafumi Sangai, Motoi Nishimura, Kazuyuki Matsushita, Akira Hata, Fumio Nomura, Ituro Inoue
Genetic testing for breast cancer predisposing genes, BRCA1 and BRCA2, can take advantage for early identification of carriers with pathogenic germline mutations. However, conventional approaches based on Sanger sequencing are laborious and expensive. Next-generation sequencing technology has a great impact on investigation of medical genomics and now applied clinical genetics. We provide a protocol based on a pool and capture method followed by high-throughput sequencing, which realizes a rapid, high-quality, high-accuracy and low-cost testing for mutations in BRCA1 and BRCA2 by using small amounts of input DNA...
February 9, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28178054/safety-of-tetanus-diphtheria-and-pertussis-vaccination-during-pregnancy-a-systematic-review
#19
Mark McMillan, Michelle Clarke, Adriana Parrella, Deshayne B Fell, Gayatri Amirthalingam, Helen S Marshall
OBJECTIVE: To assess antenatal, birth, and infant outcomes for pregnant women, fetuses, and infants after antenatal vaccination with any antigen present in combination pertussis vaccines. DATA SOURCES: PubMed, EMBASE, Literature in the Health Sciences in Latin America and the Caribbean, ClinicalTrials.gov, Cochrane Library, and World Health Organization (inception to May 5, 2016). METHODS OF STUDY SELECTION: Studies reporting outcomes for pregnant women, their fetus, or infant after antenatal exposure to either monovalent or combined tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) or inactivated polio vaccines were considered for inclusion...
February 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28169118/bone-health-and-bone-targeted-therapies-for-prostate-cancer-a-programme-in-evidence-based-care-cancer-care-ontario-clinical-practice-guideline
#20
S M H Alibhai, K Zukotynski, C Walker-Dilks, U Emmenegger, A Finelli, S C Morgan, S J Hotte, E Winquist
AIMS: To make recommendations with respect to bone health and bone-targeted therapies in men with prostate cancer. MATERIALS AND METHODS: A systematic review was carried out by searching MEDLINE, EMBASE and the Cochrane Library from inception to January 2016. Systematic reviews and randomised-controlled trials were considered for inclusion if they involved therapies directed at improving bone health or outcomes such as skeletal-related events, pain and quality of life in patients with prostate cancer either with or without metastases to bone...
February 3, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
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