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https://www.readbyqxmd.com/read/29676136/-network-meta-analysis-of-chinese-medical-injections-for-heart-failure
#1
Feng-Wen Yang, Jia-Han Zou, Yuan Wang, Chong-Xiang Sun, Long Ge, Jin-Hui Tian, Jun-Hua Zhang
To assess the clinical efficacy of Chinese medical injection (CMI) for heart failure by using network Meta-analysis method. The relative randomized controlled trials (RCTs) of CMI for heart failure were retrieved from China National Knowledge Infrastructure (CNKI), WanFang Database, Chinese Biomedical Literature Database (SinoMed), PubMed, Cochrane Library and EMbase in July 2017. RCTs on the comparison of two kinds of CMIs for heart failure were included. Two researchers independently completed the literature screening, data extraction and quality evaluation according to the pre-determined inclusion and exclusion criteria, and the results were crossed checked...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675673/systematic-review-of-the-complications-associated-with-magnetically-controlled-growing-rods-for-the-treatment-of-early-onset-scoliosis
#2
REVIEW
Chrishan Thakar, David Christopher Kieser, Mihai Mardare, Shahnawaz Haleem, Jeremy Fairbank, Colin Nnadi
PURPOSE: To analyse the complication profile of magnetically controlled growing rods (MCGRs) in early onset scoliosis (EOS). METHODS: This is a systematic review using PUBMED, Medline, Embase, Google Scholar and the Cochrane Library (keywords: MAGEC, Magnetically controlled growing rods and EOS) of all studies written in English with a minimum of five patients and a 1-year follow-up. We evaluated coronal correction, growth progression (T1-S1, T1-T12) and complications...
April 19, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29668895/evidence-to-improve-physical-activity-among-medically-underserved-older-adults-a-scoping-review
#3
Yi-Ling Hu, Kristin Junge, An Nguyen, Kelsey Hiegel, Emily Somerville, Marian Keglovits, Susan Stark
Background and Objectives: Participation in leisure physical activity (PA) and engagement in PA interventions among older adults is influenced by socioeconomic status (SES), race/ethnicity, and environment. However, studies of PA for medically underserved older adults have not yet been systematically evaluated. The objective of this study is to map the nature and extent of research conducted on PA participation, interventions, and components of effective leisure PA programs for medically underserved older adults...
April 16, 2018: Gerontologist
https://www.readbyqxmd.com/read/29667554/establishment-of-novel-reporter-cells-stably-maintaining-transcription-factor-driven-human-secreted-alkaline-phosphatase-expression
#4
Riho Kurata, Asuka Kumagai, Xiaofeng Cui, Masamitsu Harada, Jun Nagai, Yasuhiro Yoshida, Kei-Ichi Ozaki, Yoshimasa Tanaka, Tomo Yonezawa
BACKGROUND: Transcriptional regulation is very important and pivotal function in myriad biological responses. Thus, methods to determine transcriptional activity are required in not only basic medical research but also drug discovery. We established novel reporter constructs using human secreted embryonic alkaline phosphatase (SEAP) and Epstein-Barr virus nuclear antigen (EBNA) 1, which can maintain constructs synchronized to host cell replication. METHODS: We established nuclear factor-kappa B (NFkB) or interferon regulatory factor (IRF) driven SEAP expression constructs and then, introduced them into culture cells...
April 17, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29666309/hospital-admissions-associated-with-medication-non-adherence-a-systematic-review-of-prospective-observational-studies
#5
Pajaree Mongkhon, Darren M Ashcroft, C Norman Scholfield, Chuenjid Kongkaew
BACKGROUND: Medication non-adherence in ambulatory care has received substantial attention in the literature, but less so as it affects acute care. Accordingly, we aimed to estimate the frequency with which non-adherence to medication contributes to hospital admissions. METHODS: We searched the Cochrane Library, EMBASE, Cumulative Index to Nursing and Allied Health Literature, International Pharmaceutical Abstracts and PubMed (until December 2017) to identify prospective observational studies that examined prevalence rates of hospital admissions associated with medication non-adherence...
April 17, 2018: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29666199/does-magnesium-sulfate-have-a-role-in-the-management-of-severe-traumatic-brain-injury-in-civilian-and-military-populations-a-systematic-review-and-meta-analysis
#6
REVIEW
Marc W H Lyons, W J Blackshaw
INTRODUCTION: Traumatic brain injury (TBI) is a significant cause of combat morbidity. Currently, the medical management of TBI is limited to supportive critical care. Magnesium sulfate has been studied as a potentially beneficial therapeutic agent. METHODS: A systematic review and meta-analysis was undertaken, examining the role of magnesium in the management of severe TBI in adults. The primary outcome of the study was all-cause mortality, with secondary outcomes of Glasgow Outcome Score (GOS) and GCS...
April 17, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29666136/systematic-review-and-meta-analysis-of-diabetes-mellitus-cardiovascular-and-respiratory-condition-epidemiology-in-sexual-minority-women
#7
Catherine Meads, Adam Martin, Jeffrey Grierson, Justin Varney
OBJECTIVE: Sexual minority women (SMW) experience higher chronic disease risk factors than heterosexual counterparts. However, it was unclear if these risks translate into higher physical condition rates. This systematic review evaluates cardiovascular disease (CVD), hypertension, respiratory disease and diabetes mellitus in SMW. METHODS: A protocol was registered with the Prospero database (CRD42016050299). Included were studies reporting mortality, incidence or prevalence of the above-listed conditions in SMW compared with heterosexual women...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29664514/-damage-control-resuscitation-in-pediatric-severe-trauma
#8
Adriana Wegner Araya
INTRODUCTION: Trauma is an important cause of morbidity and mortality in the pediatric population. It has the first place in mortality in our country without considering perinatal pathologies and congenital malformations. An important percentage of early and late deaths secondary to this cau se, as well as its sequelae, could be prevented with optimal and timely resuscitation. OBJECTIVE: To review the applicability of damage control resuscitation (DCR) in severe pediatric trauma, with emphasis on medical management...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29664177/-osler-warned-was-william-osler-a-grave-robber-while-at-mcgill-or-was-he-a-victim-or-perpetrator-of-one-final-practical-joke
#9
James R Wright
Bodysnatching was an illegal way to procure cadavers for anatomical dissection before the existence of effective anatomy legislation. As knowledge of anatomy was fundamental to medical practice, many famous 19th century physicians turned a blind eye to this activity or even participated. Sir William Osler, perhaps the most revered physician of all time, received his medical degree from McGill University in 1872 and then served as pathologist at Montreal General Hospital from 1874 to 1884, where he began a career which culminated in him becoming both the first Professor of Medicine at Johns Hopkins and then Regius Professor at Oxford...
April 17, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29662294/application-of-enhanced-recovery-after-gastric-cancer-surgery-an-updated-meta-analysis
#10
Liu-Hua Wang, Ren-Fei Zhu, Cheng Gao, Shou-Lin Wang, Li-Zong Shen
AIM: To provide an updated assessment of the safety and efficacy of enhanced recovery after surgery (ERAS) protocols in elective gastric cancer (GC) surgery. METHODS: PubMed, Medline, EMBASE, World Health Organization International Trial Register, and Cochrane Library were searched up to June 2017 for all available randomized controlled trials (RCTs) comparing ERAS protocols and standard care (SC) in GC surgery. Thirteen RCTs, with a total of 1092 participants, were analyzed in this study, of whom 545 underwent ERAS protocols and 547 received SC treatment...
April 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29658790/a-high-throughput-time-resolved-fluorescence-energy-transfer-assay-to-screen-for-modulators-of-rgs7-g%C3%AE-5-r7bp-complex
#11
Brian S Muntean, Dipak N Patil, Franck Madoux, James Fossetta, Louis Scampavia, Timothy P Spicer, Kirill A Martemyanov
G protein-coupled receptors (GPCRs) are excellent drug targets exploited by majority of the Food and Drug Administration-approved medications, but when modulated, are often accompanied by significant adverse effects. Targeting of other elements in GPCR pathways for improved safety and efficacy is thus an unmet need. The strength of GPCR signaling is tightly regulated by regulators of G protein signaling (RGS) proteins, making them attractive drug targets. We focused on a prominent RGS complex in the brain consisting of RGS7 and its binding partners Gβ5 and R7BP...
April 2018: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/29652908/automatic-lesion-detection-and-segmentation-of-18f-fet-pet-in-gliomas-a-full-3d-u-net-convolutional-neural-network-study
#12
Paul Blanc-Durand, Axel Van Der Gucht, Niklaus Schaefer, Emmanuel Itti, John O Prior
INTRODUCTION: Amino-acids positron emission tomography (PET) is increasingly used in the diagnostic workup of patients with gliomas, including differential diagnosis, evaluation of tumor extension, treatment planning and follow-up. Recently, progresses of computer vision and machine learning have been translated for medical imaging. Aim was to demonstrate the feasibility of an automated 18F-fluoro-ethyl-tyrosine (18F-FET) PET lesion detection and segmentation relying on a full 3D U-Net Convolutional Neural Network (CNN)...
2018: PloS One
https://www.readbyqxmd.com/read/29652246/metformin-in-non-diabetic-hyperglycaemia-the-glint-feasibility-rct
#13
Simon J Griffin, M Angelyn Bethel, Rury R Holman, Kamlesh Khunti, Nicholas Wareham, Gwen Brierley, Melanie Davies, Andrew Dymond, Rose Eichenberger, Philip Evans, Alastair Gray, Colin Greaves, Kyla Harrington, Graham Hitman, Greg Irving, Sarah Lessels, Ann Millward, John R Petrie, Martin Rutter, Mike Sampson, Naveed Sattar, Stephen Sharp
BACKGROUND: The treatment of people with diabetes with metformin can reduce cardiovascular disease (CVD) and may reduce the risk of cancer. However, it is unknown whether or not metformin can reduce the risk of these outcomes in people with elevated blood glucose levels below the threshold for diabetes [i.e. non-diabetic hyperglycaemia (NDH)]. OBJECTIVE: To assess the feasibility of the Glucose Lowering In Non-diabetic hyperglycaemia Trial (GLINT) and to estimate the key parameters to inform the design of the full trial...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29651981/lamotrigine-for-people-with-borderline-personality-disorder-a-rct
#14
Mike J Crawford, Rahil Sanatinia, Barbara Barrett, Gillian Cunningham, Oliver Dale, Poushali Ganguli, Geoff Lawrence-Smith, Verity C Leeson, Fenella Lemonsky, Georgia Lykomitrou-Matthews, Alan Montgomery, Richard Morriss, Jasna Munjiza, Carol Paton, Iwona Skorodzien, Vineet Singh, Wei Tan, Peter Tyrer, Joseph G Reilly
BACKGROUND: No drug treatments are currently licensed for the treatment of borderline personality disorder (BPD). Despite this, people with this condition are frequently prescribed psychotropic medications and often with considerable polypharmacy. Preliminary studies have indicated that mood stabilisers may be of benefit to people with BPD. OBJECTIVE: To examine the clinical effectiveness and cost-effectiveness of lamotrigine for people with BPD. DESIGN: A two-arm, double-blind, placebo-controlled individually randomised trial of lamotrigine versus placebo...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29651945/modeling-of-a-cyclotron-target-for-the-production-of-11c-with-geant4
#15
Andrea Chiappiniello, Federico Zagni, Angelo Infantino, Sara Vichi, Gianfranco Cicoria, Maria Pia Morigi, Mario Marengo
BACKGROUND: In medical cyclotron facilities, 11C is produced according to the 14N(p,α)11C reaction and widely employed in studies of prostate and brain cancers by Positron Emission Tomography. It is known from literature [1] that the 11C-target assembly shows a reduction in efficiency during time, meaning a decrease of activity produced at the end of bombardment. This effect might depend on aspects still not completely known. OBJECTIVE: Possible causes of the loss of performance of the 11C-target assembly were addressed by Monte Carlo simulations...
April 12, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29650810/-artificial-intelligence-in-drug-discovery
#16
Takeshi Fujiwara, Mayumi Kamada, Yasushi Okuno
According to the increase of data generated from analytical instruments, application of artificial intelligence(AI)technology in medical field is indispensable. In particular, practical application of AI technology is strongly required in "genomic medicine" and "genomic drug discovery" that conduct medical practice and novel drug development based on individual genomic information. In our laboratory, we have been developing a database to integrate genome data and clinical information obtained by clinical genome analysis and a computational support system for clinical interpretation of variants using AI...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29649989/evaluation-of-efficacy-and-safety-for-brucea-javanica-oil-emulsion-in-the-control-of-the-malignant-pleural-effusions-via-thoracic-perfusion
#17
Dai Fuhong, Gao Xiang, Li Haiying, Wang Jiangye, Gao Xueming, Chai Wenxiao
BACKGROUND: Brucea javanica oil emulsion (BJOE) is traditional Chinese medicine with implicated anti-tumor activity, which has been used for treating lung cancer in China. The aim of this investigation was to evaluate the effects and safety of intrapleural injection of BJOE in treating malignant pleural effusion (MPE). METHODS: The randomised controlled trials (RCTs) on the effects and safety of BJOE in treating MPE were searched from electronic medical database including MEDLINE, SCI, EMBASE, Cochrance Library and CNKI...
April 12, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29649837/-cost-effectiveness-and-cost-utility-analyses-of-antireflux-medicine
#18
Ines Gockel, Undine Gabriele Lange, Olaf Schürmann, Boris Jansen-Winkeln, Rainer Sibbel, Orestis Lyros, Nikolaus von Dercks
INTRODUCTION: Laparoscopic antireflux surgery and medical therapy with proton pump inhibitors are gold standards of gastroesophageal reflux treatment. On account of limited resources and increasing healthcare needs and costs, in this analysis, not only optimal medical results, but also superiority in health economics of these 2 methods are evaluated. METHODS: We performed an electronic literature survey in MEDLINE, PubMed, Cochrane Library, ISRCTN (International Standard Randomization Controlled Trial Number) as well as in the NHS Economic Evaluation Database, including studies published until 1/2017...
April 12, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29645361/perioperative-analgesia-for-patients-undergoing-endoscopic-sinus-surgery-an-evidence-based-review
#19
REVIEW
Peter F Svider, Brandon Nguyen, Brian Yuhan, Giancarlo Zuliani, Jean Anderson Eloy, Adam J Folbe
BACKGROUND: Misuse and diversion of prescription opioids have been critical in facilitating the opioid epidemic. Our objective was to perform a systematic evidence-based review delineating perioperative regimens (including opioid alternatives) evaluated for endoscopic sinus surgery. METHODS: PubMed/MEDLINE, Cochrane Library, and EmBase databases were evaluated for studies detailing analgesics employed after endoscopic sinus surgery. Studies were assessed for level of evidence...
April 12, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29642776/the-pink-underside-the-commercialization-of-medical-risk-assessment-and-decision-making-tools-for-hereditary-breast-cancer-risk
#20
Sharlene Hesse-Biber, Bailey Flynn, Keeva Farrelly
The growth of the Internet since the millennium has opened up a myriad of opportunities for education, particularly in medicine. Although those looking for health care information used to have to turn to a face-to-face doctor's visit, an immense library of medical advice is now available at their fingertips. The BRCA genetic predispositions (mutations of the BRCA1 and BRCA2 breast cancer genes) which expose men and women to greater risk of breast, ovarian, and other cancers can be researched extensively online...
April 1, 2018: Qualitative Health Research
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