Arnar Rafnsson, Ljubica Perisic Matic, Mariette Lengquist, Ali Mahdi, Alexey Shemyakin, Gabrielle Paulsson-Berne, Göran K Hansson, Anders Gabrielsen, Ulf Hedin, Jiangning Yang, John Pernow
BACKGROUND AND AIMS: Endothelin-1 (ET-1) and arginase are both suggested to be involved in the inflammatory processes and development of endothelial dysfunction in atherosclerosis. However, information regarding the roles of ET-1 and arginase, as well as the interactions between the two in human atherosclerosis, is scarce. We investigated the expression of ET-1 and its receptors, ETA and ETB , as well as arginase in human carotid atherosclerotic plaques and determined the functional interactions between ET-1 and arginase in endothelial cells and THP-1-derived macrophages...
October 1, 2019: Atherosclerosis