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https://www.readbyqxmd.com/read/29144820/pheochromocytoma-a-genetic-and-diagnostic-update
#1
Leilani B Mercado-Asis, Katherine I Wolf, Ivana Jochmanova, David Taïeb
OBJECTIVE: Pheochromocytomas and paragangliomas (PPGLs) are neuroendocrine tumors derived from adrenal or extra-adrenal locations, respectively. Upon suspicion of PPGL, specific metabolomic, molecular, biochemical, imaging, and histopathological studies are performed to prove, localize, treat, and monitor disease progression. Recently, improved diagnostic tools allow physicians to accurately diagnose PPGL, even in patients presenting with small (less than 1 cm) or biochemically silent tumors, which previously delayed proper detection and treatment...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29143280/genome-sequencing-and-phylogenetic-analysis-of-banna-virus-genus-seadornavirus-family-reoviridae-isolated-from-culicoides
#2
Song Song, Yuanyuan Li, Shihong Fu, Wenwen Lei, Xiaofang Guo, Yun Feng, Xiaoyan Gao, Xiaolong Li, Zhonghua Yang, Ziqian Xu, Ying He, Huanyu Wang, Hongning Zhou, Bin Wang, Xiaoqing Lu, Guodong Liang
In an investigation of blood-sucking insects and arboviruses, a virus (YN12243) was isolated from Culicoides samples collected in the Sino-Burmese border region of Yunnan Province, China. The virus caused cytopathic effect (CPE) in C6/36 cells and passaged stably. Polyacrylamide gel analysis showed that the genome of YN12243 was composed of 12 segments of double-stranded RNA (dsRNA), with a distribution pattern of 6-6. The nucleotide and amino acid sequences of the coding region (1‒12 segments) were 17,803 bp and 5,925 amino acids in length, respectively...
October 26, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/29141402/-epidemiology-of-the-carbapenemase-producing-enterobacteriaceae-spread-in-a-community-acute-hospital-and-a-non-acute-rehabilitation-hospital-in-madrid
#3
M López-Dosil, C Bischofberge, D Sáez, C García-Picazo
OBJECTIVE: In Spain, the overall prevalence of carbapenem-resistant Enterobacteriaceae (CRE) is increasing. We describe the epidemiological, clinical and microbiological characteristics features of patients with colonization or infection due to CRE in two hospitals in the north-west of Madrid during two years. One hospital was a community acute hospital and the second one was a non-acute rehabilitation hospital. METHODS: A total of 197 CPE isolates were detected during 2013-2014...
November 14, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29141051/molecular-and-epidemiological-characterization-of-carbapenemase-producing-enterobacteriaceae-in-norway-2007-to-2014
#4
Ørjan Samuelsen, Søren Overballe-Petersen, Jørgen Vildershøj Bjørnholt, Sylvain Brisse, Michel Doumith, Neil Woodford, Katie L Hopkins, Bettina Aasnæs, Bjørg Haldorsen, Arnfinn Sundsfjord
The prevalence of carbapenemase-producing Enterobacteriaceae (CPE) is increasing worldwide. Here we present associated patient data and molecular, epidemiological and phenotypic characteristics of all CPE isolates in Norway from 2007 to 2014 confirmed at the Norwegian National Advisory Unit on Detection of Antimicrobial Resistance. All confirmed CPE isolates were characterized pheno- and genotypically, including by whole genome sequencing (WGS). Patient data were reviewed retrospectively. In total 59 CPE isolates were identified from 53 patients...
2017: PloS One
https://www.readbyqxmd.com/read/29129527/identification-of-measles-virus-genotype-b3-associated-with-outbreaks-in-islamabad-pakistan-2013-2015
#5
Syed Sohail Zahoor Zaidi, Abdul Hameed, Muhammad Suleman Rana, Muhammad Masroor Alam, Massab Umair, Uzma Bashir Aamir, Maqbool Hussain, Salmaan Sharif, Shahzad Shaukat, Mehar Angez, Adnan Khurshid
BACKGROUND: Measles virus infection remains a significant cause of childhood mortality and morbidity despite continued global efforts and the availability of a safe and effective vaccine. Molecular analysis of indigenous measles viruses could provide critical information on outbreak linkages and transmission pathways that can aid the implementation of appropriate control programs in Pakistan. METHODS: Blood samples and throat swabs were collected from subjects suspected with measles in Islamabad, Pakistan from 2013 to 2015...
November 9, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29126942/design-of-an-electrochemical-dna-based-biosensor-for-selective-determination-of-cadmium-ions-using-a-dna-hybridization-indicator
#6
Maryam Ebrahimi, Jahan Bakhsh Raoof, Reza Ojani
A simple electrochemical DNA- based biosensor was designed for determination of Cd(2+) using ethyl green (EG) as a DNA hybridization indicator on the surface of carbon paste electrode (CPE). The interaction of Cd(2+) with double strand DNA (dsDNA) led to the destabilizing of dsDNA and the increase in the reduction peak currents of EG. The difference in the values of electrochemical responses of EG before and after DNA helix destabilization in the presence of Cd(2+) (ΔI) was used for Cd(2+) determination and was linearly related to the concentration of Cd(2+) over the ranges of 1...
November 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29126110/risks-of-infection-and-mortality-among-patients-colonized-with-kpc-producing-klebsiella-pneumoniae-validation-of-scores-and-proposal-for-management
#7
Angela Cano, Belén Gutiérrez-Gutiérrez, Isabel Machuca, Irene Gracia-Ahufinger, Elena Pérez-Nadales, Manuel Causse, Juan José Castón, Julia Guzman-Puche, Julian Torre-Giménez, Lara Kindelán, Luis Martínez-Martinez, Jesús Rodriguez-Baño, Julian Torre-Cisneros
Background: The management and indication of empirical treatment in Klebsiella pneumoniae-carbapenemase producing K. pneumoniae (KPC-Kp) colonized patients should be improved. Methods: A prospective cohort of 94 patients colonized by KPC-Kp was followed for 90 days to validate: (i) the Giannella risk score (GRS) to predict the development of any type of KPC-Kp infection and (ii) the INCREMENT-CPE score (ICS) to predict 30-day mortality in patients with infection...
November 8, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29120265/do-journal-clubs-work-the-effectiveness-of-journal-clubs-in-a-clinical-pastoral-education-residency-program
#8
David Fleenor, Vanshdeep Sharma, Jo Hirschmann, Heidi Swarts
Journal clubs are an established means of ongoing learning in medicine. Beginning with physicians in the nineteenth century, journal clubs have gradually become established in nursing and other allied health professions. However, their use in Clinical Pastoral Education (CPE) is relatively new. We describe the creation of a journal club for CPE residents and discuss the lessons learned from this effort. Over two years, a journal club was conducted with two different cohorts of residents. Residents were surveyed regarding the perceived strengths and weaknesses of the journal club and their recommendations for improvement...
November 9, 2017: Journal of Health Care Chaplaincy
https://www.readbyqxmd.com/read/29115369/useful-independent-factors-for-distinguish-infection-and-colonization-in-patients-with-urinary-carbapenemase-producing-enterobacteriaceae-isolation
#9
L López-González, F J Candel, J M Viñuela-Prieto, J González-Del Castillo, A B García, I Pena, I Rodríguez-Avial
OBJECTIVE: The aim of this study is to know epidemiologic and clinical differences among those patients colonized or infected by carbapenemase-producing Enterobacteriaceae (CPE) and develop a predictive model to facilitate the clinical approach concerning to start antimicrobial therapy. METHODS: Observational retrospective cohort study was performed involving all patients with Urine carbapenemase-producing Enterobacteriaceae isolation (UCPEI) between November 2013 and July 2015...
November 7, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29109448/identification-of-claudin-4-binder-that-attenuates-tight-junction-barrier-function-by-tr-fret-based-screening-assay
#10
Akihiro Watari, Miki Kodaka, Koji Matsuhisa, Yuta Sakamoto, Kota Hisaie, Norihito Kawashita, Tatsuya Takagi, Yoshiaki Yamagishi, Hidehiko Suzuki, Hirofumi Tsujino, Kiyohito Yagi, Masuo Kondoh
Claudins are key functional and structural components of tight junctions (TJs) in epithelial cell sheets. The C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE) binds to claudin-4 and reversibly modulates intestinal TJ seals, thereby enhancing paracellular transport of solutes. However, the use of C-CPE as an absorption enhancer is limited by the molecule's immunogenicity and manufacturing cost. Here, we developed a high-throughput screening system based on the Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) method to identify claudin-4 binders in a library collection of 32,560 compounds...
November 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29108951/automated-time-lapse-microscopy-a-novel-method-for-screening-of-antibiotic-combination-effects-against-multidrug-resistant-gram-negative-bacteria
#11
Wanchana Ungphakorn, Pernilla Lagerbäck, Elisabet I Nielsen, Thomas Tängdén
OBJECTIVES: Antibiotic combinations are often used for carbapenemase-producing Enterobacteriaceae (CPE) but more data are needed on the optimal selection of drugs. This study aimed to evaluate the feasibility of a novel automated method based on time-lapse microscopy (the oCelloScope, Philips BioCell A/S, Allerød, Denmark) to determine in vitro combination effects against CPE and to discuss advantages and limitations of the oCelloScope in relation to standard methods. METHODS: Four Klebsiella pneumoniae and two Escherichia coli were exposed to colistin, meropenem, rifampin and tigecycline, alone and in combination...
November 3, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29106902/the-use-of-m-mode-ultrasonography-to-differentiate-the-etiology-of-b-lines
#12
Anup K Singh, Paul H Mayo, Seth Koenig, Aranabh Talwar, Mangala Narasimhan
BACKGROUND: The presence of B lines on lung ultrasonography is a characteristic feature of both cardiogenic pulmonary edema (CPE) and non cardiogenic alveolar interstitial syndrome (NCAIS), so their presence does not allow the clinician to differentiate between the two entities. Our study uses M mode ultrasonography of the pleura to differentiate cardiogenic pulmonary edema vs. non cardiogenic alveolar interstitial syndrome. METHODS: A total of 43 subjects were enrolled in the study and based upon history, physical examination, and chart review the patients were divided into three groups...
October 26, 2017: Chest
https://www.readbyqxmd.com/read/29097045/are-advanced-practice-pharmacist-designations-really-advanced
#13
Timothy P Frost, Alex J Adams
Four states have created advanced practice pharmacist designations in state law: advanced practice pharmacist (California), clinical pharmacist practitioner (Montana and North Carolina), and pharmacist clinician (New Mexico). To attain an advanced pharmacist designation, states typically require a fee and set a minimum education requirement either through continuing pharmacy education (CPE) or through attainment of a national certification or completion of a residency. Once attained, pharmacists may practice with additional scope of practice authorities, namely the ability to order and interpret drug therapy-related tests, and initiate or adjust/modify medications under a collaborative practice agreement (CPA)...
October 7, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29096452/intermolecular-interactions-in-the-condensed-phase-evaluation-of-semi-empirical-quantum-mechanical-methods
#14
Anders S Christensen, Jimmy C Kromann, Jan H Jensen, Qiang Cui
To facilitate further development of approximate quantum mechanical methods for condensed phase applications, we present a new benchmark dataset of intermolecular interaction energies in the solution phase for a set of 15 dimers, each containing one charged monomer. The reference interaction energy in solution is computed via a thermodynamic cycle that integrates dimer binding energy in the gas phase at the coupled cluster level and solute-solvent interaction with density functional theory; the estimated uncertainty of such calculated interaction energy is ±1...
October 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29095123/charting-our-course-chaplain-documentation-as-a-performance-improvement-project
#15
Alexander Tartaglia, Timothy Ford, Diane Dodd-McCue, Christine Reid, Carolyn Hawley, Alma Hassell
This article presents the results of a 30-month process improvement initiative examining the spiritual assessment documentation patterns of staff chaplains as well as CPE residents and interns at an academic medical center. Preliminary examination of chaplain documentation patterns led to a multidimensional intervention to address perceived documentation limitations and enhance reliability. The intervention resulted in positive changes in documentation patterns as assessed by an expert panel of experienced chaplains...
November 2, 2017: Journal of Health Care Chaplaincy
https://www.readbyqxmd.com/read/29094540/role-of-clinical-practice-educators-in-an-integrated-community-and-mental-health-nhs-foundation-trust
#16
Jane Hampson, Hazel Gunning, Louise Nicholson, Carol Gee, Dawne Jay, Gerry Sheppard
Clinical practice educators (CPEs) aim to provide support and education to clinical staff and students to improve their professional practice. This article examines the work of a team of six CPEs, who were employed by one large integrated mental health and community health NHS foundation trust that incorporates both mental and physical health services. It explores how the role of the CPE can have positive effects on clinical settings, and can improve the provision of evidence-based care for clinical staff and students on placement in the trust...
October 11, 2017: Nursing Standard
https://www.readbyqxmd.com/read/29091543/in-silico-design-of-a-novel-chimeric-shigella-ipab-fused-to-c-terminal-of-clostridium-perfringens-enterotoxin-as-a-vaccine-candidate
#17
Sina Arabshahi, Bahar Nayeri Fasaei, Abdollah Derakhshandeh, Aytak Novinrooz
This study aimed to design a novel chimeric protein in silico to serve as a serotype-independent vaccine candidate against Shigella. The chimera contains amino acid residues 240-460 of Shigella invasion plasmid antigen B (IpaB) and the C-terminus of Clostridium perfringens enterotoxin (C-CPE). Amino acid sequences of 537 peptide linkers were obtained from two protein linker databases. 3D structures of IpaB-CPE290-319, IpaB-CPE184-319, IpaB-CPE194-319 and 537 newly designed IpaB-linker-CPE290-319 constructs with varying linker regions were predicted...
November 1, 2017: Bioengineered
https://www.readbyqxmd.com/read/29083861/self-similar-interfacial-impedance-of-electrodes-in-high-conductivity-media
#18
Anil Koklu, Amin Mansoorifar, Ali Beskok
Electrode polarization (EP) happening due to accumulation of ions at the electrode/electrolyte interface is an inevitable phenomenon while measuring impedance spectrum in high conductivity buffers and at low RF spectrum. Well-characterized time scales elucidating the EP effect are important for the rational design of microfluidic devices and impedance sensors. In this Article, interfacial impedance at the electrode/electrolyte interface is investigated considering channel height and Debye length effects on characteristic time scale in a binary electrolyte solution using parallel plate electrode configuration...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29080685/functional-characterization-of-interferon-regulatory-factor-5-and-its-role-in-the-innate-antiviral-immune-response
#19
Kete Ai, Kai Luo, Lihai Xia, Weihua Gao, Wei Hu, Zhitao Qi, Qiaoqing Xu
In mammals, type I interferons (IFNs) are primarily regulated by transcription factors of the IFN regulatory (IRF) family. Interferon regulatory factor 5 (IRF-5) plays pivotal roles in antiviral and inflammatory responses. In the present study, we found that zebrafish (Danio rerio) IRF5 is a key player in the regulation of the expression of type I IFN and its antiviral immune response. IRF5 was upregulated in zebrafish embryonic fibroblast cells (ZF4) when challenged with grass carp reovirus (GCRV). Moreover, the expression profiles of Mx, IFN, Viperin, and IRF7, but not IRF3, were upregulated by overexpression of IRF5 in Epithelioma papulosum cyprinid cells (EPCs)...
October 28, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29076442/-carbapenemase-producing-enterobacteriaceae-in-the-netherlands-unnoticed-spread-to-several-regions
#20
T Leenstra, T Bosch, A L Vlek, M J M Bonten, I M van der Lubben, S C de Greeff
- Carbapenemase producing Enterobacteriaceae (CPE), including Klebsiella pneumoniae and Escherichia coli, are only sporadically seen in the Netherlands and then mainly in patients who have been transferred from foreign hospitals.- CPE are resistant to virtually all beta-lactam antibiotics, including carbapenems, e.g., meropenem and imipenem. Several genes, e.g., OXA-48, KPC and NDM-1, code for carbapenemase enzymes that deactivate carbapenems.- Control of CPE focuses on timely identification of patients who are infected or are carriers and the application of preventive measures to prevent spread...
2017: Nederlands Tijdschrift Voor Geneeskunde
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