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https://www.readbyqxmd.com/read/28944726/paying-for-cures-how-can-we-afford-it-managed-care-pharmacy-stakeholder-perceptions-of-policy-options-to-address-affordability-of-prescription-drugs
#1
Kai Yeung, Kangho Suh, Anirban Basu, Louis P Garrison, Aasthaa Bansal, Josh J Carlson
BACKGROUND: High-priced medications with curative potential, such as the newer hepatitis C therapies, have contributed to the recent growth in pharmaceutical expenditure. Despite the obvious benefits, health care decision makers are just beginning to grapple with questions of how to value and pay for curative therapies that may feature large upfront cost, followed by health benefits that are reaped over a patient's lifespan. Alternative policy options have been proposed to promote high value and financially sustainable use of these therapies...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28941910/bicarbonate-and-amino-acids-are-co-germinants-for-spores-of-clostridium-perfringens-type-a-isolates-carrying-plasmid-borne-enterotoxin-gene
#2
Maryam Alnoman, Pathima Udompijitkul, Saeed Banawas, Mahfuzur R Sarker
Clostridium perfringens type A isolates carrying a chromosomal enterotoxin (cpe) gene (C-cpe) are generally linked to food poisoning, while isolates carrying cpe on a plasmid (P-cpe) are associated with non-food-borne gastrointestinal diseases. Both C-cpe and P-cpe isolates can form metabolically dormant spores, which through germination process return to actively growing cells to cause diseases. In our previous study, we showed that only 3 out of 20 amino acids (aa) in phosphate buffer (pH 7.0) triggered germination of spores of P-cpe isolates (P-cpe spores)...
February 2018: Food Microbiology
https://www.readbyqxmd.com/read/28940687/efficient-isolation-of-human-metapneumovirus-using-mnt-1-a-human-malignant-melanoma-cell-line-exhibiting-early-and-distinct-cytopathic-effect
#3
Ko Sato, Oshi Watanabe, Suguru Ohmiya, Fumiko Chiba, Akira Suzuki, Michiko Okamoto, Jiang Younghuang, Akihiro Hata, Hiroyuki Nonaka, Setsuko Kitaoka, Yukio Nagai, Kazuhisa Kawamura, Masahiro Hayashi, Satoru Kumaki, Tamio Suzuki, Kazuyoshi Kawakami, Hidekazu Nishimura
Isolation of human metapneumovirus (HMPV) from clinical specimens is currently inefficient due to the lack of a cell culture system exhibiting a distinct cytopathic effect (CPE). The cell lines LLC-MK2, Vero, and Vero E6 are used for isolation of HMPV; however, the CPE in these cell lines is subtle and usually requires a long observation period and sometimes blind passages. Thus, a cell line that exhibits an early and distinct CPE following HMPV inoculation is highly desired by clinical virology laboratories...
September 20, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28933760/infectious-bronchitis-virus-infection-induces-apoptosis-during-replication-in-chicken-macrophage-hd11-cells
#4
Xiaoxiao Han, Yiming Tian, Ru Guan, Wenqian Gao, Xin Yang, Long Zhou, Hongning Wang
Avian infectious bronchitis has caused huge economic losses in the poultry industry. Previous studies have reported that infectious bronchitis virus (IBV) infection can produce cytopathic effects (CPE) and apoptosis in some mammalian cells and primary cells. However, there is little research on IBV-induced immune cell apoptosis. In this study, chicken macrophage HD11 cells were established as a cellular model that is permissive to IBV infection. Then, IBV-induced apoptosis was observed through a cell viability assay, morphological changes, and flow cytometry...
July 26, 2017: Viruses
https://www.readbyqxmd.com/read/28917742/analysis-of-glutathione-in-the-presence-of-acetaminophen-and-tyrosine-via-an-amplified-electrode-with-mgo-swcnts-as-a-sensor-in-the-hemolyzed-erythrocyte
#5
Fahimeh Tahernejad-Javazmi, Mehdi Shabani-Nooshabadi, Hassan Karimi-Maleh
In this study, we investigated the effect of adding MgO/SWCNTs and 2-Chloro-N'-[1-(2,5-dihydroxyphenyl) methylidene]aniline (2-CDHPMA) to a carbon paste matrix, which could act as a voltammetric sensor for the analysis of glutathione. The electrocatalytic interaction between 2-CDHPMA and glutathione was used as a factor for the analysis of this biological compound in real samples. In addition, the presence of MgO/SWCNTs can help in increasing the sensitivity of the fabricated sensor and for obtaining a low limit of detection in the analysis of glutathione...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28916355/grouper-stat1a-is-involved-in-antiviral-immune-response-against-iridovirus-and-nodavirus-infection
#6
Jingcheng Zhang, Xiaohong Huang, Songwei Ni, Jiaxin Liu, Yin Hu, Ying Yang, Yepin Yu, Linli Zhou, Qiwei Qin, Youhua Huang
Signal Transducer and Activator of Transcription 1 (STAT1) has been demonstrated to function as a critical mediator in multiple cell processes, such as cell proliferation, cell death, and innate immune response. Interestingly, two orthologues of human STAT1, including STAT1a and STAT1b genes have been identified in different fish. However, the detailed roles of fish STAT1a in virus replication still remained largely uncertain. Here, we cloned a STAT1a from orange-spotted grouper Epinephelus coioides (EcSTAT1a) and characterized its roles during fish virus infection...
September 12, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28914900/cycle-slip-less-low-complexity-phase-recovery-algorithm-for-coherent-optical-receivers
#7
Valery Nobl Rozental, Deming Kong, Benjamin Foo, Bill Corcoran, Arthur James Lowery
We propose and experimentally validate a blind phase recovery algorithm based on tracking low-frequency components of the phase noise, which we call "filtered carrier-phase estimation (F-CPE)." Tracking only the low-frequency components allows F-CPE to reduce the computational complexity by using a frequency-domain equalizer and to simplify the partitioning of a 16 quadrature amplitude modulation (16QAM) constellation. Further, this approach eliminates cycle slips by suppressing the impact of amplified spontaneous emission on phase noise estimation...
September 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28911670/voltammetric-sensor-for-tartrazine-determination-in-soft-drinks-using-poly-p-aminobenzenesulfonic-acid-zinc-oxide-nanoparticles-in-carbon-paste-electrode
#8
Ghasem Karim-Nezhad, Zeynab Khorablou, Maryam Zamani, Parisa Seyed Dorraji, Mahdieh Alamgholiloo
Zinc oxide nanoparticles (ZnO NPs) and p-aminobenzenesulfonic acid (p-ABSA) were used to fabricate a modified electrode, as a highly sensitive and selective voltammetric sensor, for the determination of tartrazine. A fast and easy method for the fabrication of poly p-ABSA (Pp-ABSA)/ZnO NPs-carbon paste electrode (Pp-ABSA/ZnO NPs-CPE) by cyclic voltammetry was used. By combining the benefits of Pp-ABSA, ZnO NPs, and CPE, the resulted modified electrode exhibited outstanding electrocatalytic activity in terms of tartrazine oxidation by giving much higher peak currents than those obtained for the unmodified CPE and also other constructed electrodes...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28895059/central-nervous-system-penetrating-antiretrovirals-impair-energetic-reserve-in-striatal-nerve-terminals
#9
Kelly L Stauch, Katy Emanuel, Benjamin G Lamberty, Brenda Morsey, Howard S Fox
The use of antiretroviral (ARV) drugs with central nervous system (CNS) penetration effectiveness (CPE) may be useful in the treatment of HIV-associated neurocognitive disorder (HAND) as well as targeting a CNS reservoir in strategies to achieve a functional cure for HIV. However, increased cognitive deficits are linked to at least one of these drugs (efavirenz). As mitochondrial dysfunction has been found with a number of ARVs, and as such can affect neuronal function, the objective of this study was to assess the effects of ARV with high CPE for toxicological profiles on presynaptic nerve terminal energy metabolism...
September 11, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28889259/an-ultrasensitive-and-selective-electrochemical-sensor-for-determination-of-estrone-3-sulfate-sodium-salt-based-on-molecularly-imprinted-polymer-modified-carbon-paste-electrode
#10
Han Song, Yuli Wang, Lu Zhang, Liping Tian, Jun Luo, Na Zhao, Yajie Han, Feilang Zhao, Xue Ying, Yingchun Li
A highly sensitive and selective electrochemical sensor based on carbon paste electrode (CPE) modified with molecularly imprinted polymers (MIPs) has been developed for the determination of estrone 3-sulfate sodium salt (ESS). MIPs were prepared in polar medium via bulk polymerization and characterized by scanning electron microscopy and infrared spectroscopy. Cyclic voltammetry was performed to the study preparation process and binding behavior of the MIP-modified CPE (MIP/CPE) toward ESS. The conditions for preparing MIPs and MIP/CPE as well as ESS detection were optimized...
September 9, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28884567/high-peak-pao2-values-are-associated-with-adverse-outcome-in-critically-ill-patients-treated-with-non-invasive-ventilation-for-acute-cardogenic-pulmonary-edema-and-pneumonia
#11
Christiana Schernthaner, Bernhard Wernly, Michael Lichtenauer, Marcus Franz, Alexander Lauten, Paul C Schulze, Bjoern Kabisch, Kristina Braun, Johanna Muessig, Maryna Masyuk, Uta C Hoppe, Malte Kelm, Christian Jung
BACKGROUND: Non-invasive Ventilation (NIV) has a sigificant impact on mortality in acute respiratory failure (ARF). Predictive parameters for mortality are of high interest. METHODS: We retrospectively analyzed 3759 blood gas analysis and clinical parameters of 475 patients presenting with ARF based on acute cardiogenic pulmonary edema and/or pneumonia. The influence of peak arterial oxygen partial pressure levels (PaO2) with respect to its predictive value for in-hopital and long-term mortality was investigated...
September 7, 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28882642/risk-factors-for-acquisition-of-producing-oxa-48-klebsiella-pneumonia-among-contact-patients-a-multicenter-study
#12
D Hilliquin, R Le Guern, V Thepot Seegers, C Neulier, A Lomont, V Marie, C Legeay, J Merrer, D Lepelletier, A M Rogues, B Grandbastien, J C Lucet, J R Zahar
Cohorting carbapenemase-producing Enterobacteriaceae (CPE) carriers during hospitalisation limits the in hospital spreading. Our objective was to identify risk factors for CPE acquisition among contacts of an index patient in non-cohorted populations. A multicentre retrospective matched case-control study was conducted in five hospitals. Each contact patient (case) who acquired Klebsiella pneumoniae OXA-48 from an index patient was compared to three contact (controls) with the same index patients matched with hospitalization in the same unit and similar exposure-times...
September 4, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28876029/-bioassay-guided-isolation-of-functional-components-from-hot-water-extract-of-chlorella-pyrenoidosa
#13
Jing Jia, Diansheng Xu, Xiuyuan Zhuang, Daojing Zhang, Liming Tao, Yuanguang Li
The main functional ingredients of hot water extract of Chlorella pyrenoidosa (CPE) were investigated through a bioassay-guided fractionation based on free radical scavenging and macrophage proliferation effects. The main functional ingredients of CPE were polysaccharides (PS) that were isolated by high pressure extraction, Sevag method, ethanol precipitation and ultrafiltration separation. Crude polysaccharides were further separated and purified by ion exchange chromatography DEAE52 and size exclusion chromatography Sephadex G-100...
May 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28875509/a-newly-designed-composite-gel-polymer-electrolyte-based-on-poly-vinylidene-fluoride-hexafluoropropylene-pvdf-hfp-for-enhanced-solid-state-lithium-sulfur-batteries
#14
Yan Xia, Xiuli Wang, Xinhui Xia, Ruochen Xu, Shengzhao Zhang, Jianbo Wu, Yanfei Liang, Changdong Gu, Jiangping Tu
Developing high-performance solid-state electrolyte is crucial for innovation of next-generation lithium-sulfur batteries. Herein, we report a facile method for preparation of a novel gel polymer electrolyte (GPE) based on poly(vinylidene fluoride-hexafluoropropylene) (PVDF-HFP). Furthermore, Li1.5Al0.5Ti1.5(PO4)3 (LATP) nanoparticles as the active filler are uniformly embedded into the GPE to form the final PVDF-HFP/LATP composite gel polymer electrolyte (CPE). Impressively, the obtained CPE demonstrates a high lithium ion transference number of 0...
September 5, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28875177/the-potential-therapeutic-agent-mepacrine-protects-caco-2-cells-against-clostridium-perfringens-enterotoxin-action
#15
John C Freedman, Matthew R Hendricks, Bruce A McClane
Clostridium perfringens enterotoxin (CPE) causes the diarrhea associated with a common bacterial food poisoning and many antibiotic-associated diarrhea cases. The severity of some CPE-mediated disease cases warrants the development of potential therapeutics. A previous study showed that the presence of mepacrine inhibited CPE-induced electrophysiology effects in artificial lipid bilayers lacking CPE receptors. However, that study did not assess whether mepacrine inactivates CPE or, instead, inhibits a step in CPE action...
July 2017: MSphere
https://www.readbyqxmd.com/read/28871330/forensic-features-and-phylogenetic-analyses-of-sichuan-han-population-via-23-autosomal-str-loci-included-in-the-huaxia-platinum-system
#16
Guanglin He, Mengge Wang, Jing Liu, Yiping Hou, Zheng Wang
Short tandem repeats (STRs) are DNA regions with a variable number of repeated units (2-6 bp) and attractive to genetic application like forensic, population genetics, and anthropological studies. The Huaxia Platinum System allows the multiplex amplification of 23 autosomal STR loci and two gender determination loci. In the present study, genetic polymorphisms of these 23 autosomal STR loci were first obtained from 309 Sichuan Han individuals, southwest China. No evidence of deviation from the Hardy-Weinberg equilibrium (HWE) was identified...
September 5, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28868888/selective-micellar-extraction-of-ultratrace-levels-of-uranium-in-aqueous-samples-by-task-specific-ionic-liquid-followed-by-its-detection-employing-total-reflection-x-ray-fluorescence-spectrometry
#17
Abhijit Saha, Kaushik Sanyal, Neetika Rawat, Sadhan Bijoy Deb, Manoj Kumar Saxena, Bhupendra Singh Tomar
A task specific ionic liquid (TSIL) bearing phosphoramidate group, viz., N-propyl(diphenylphosphoramidate)trimethylammonium bis(trifluoromethanesulfonyl)imide, was synthesized and characterized by (1)H NMR, (13)C NMR, (31)P NMR, and IR spectroscopies, elemental (C H N S) analysis, and electrospray ionization mass spectrometry (ESI-MS). Using this TSIL a cloud point extraction (CPE) or micelle mediated extraction procedure was developed for preconcentration of uranium (U) in environmental aqueous samples. Total reflection X-ray fluorescence spectrometry was utilized to determine the concentration of U in the preconcentrated samples...
September 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28866192/fabrication-of-biosensor-based-on-chitosan-zno-polypyrrole-nanocomposite-modified-carbon-paste-electrode-for-electroanalytical-application
#18
Amera Hassanein, Nehal Salahuddin, Atsunori Matsuda, Go Kawamura, Mona Elfiky
A sensitive conductive nanocomposite sensor consisting of chitosan, zinc oxide nanoparticles, and polypyrrole was developed. The sensor was prepared by oxidative polymerization of pyrrole using (NH4)2S2O8 as the oxidant followed by mixing a Chitosan-Zinc oxide composite with a different content of Chitosan. The morphology and surface area of the nanocomposites were changed by changing the percentage of chitosan. The newly developed nanocomposites also showed a significant improvement in electrical conductivity as mentioned from the cyclic voltammetry measurements of the K3[Fe(CN)6] sample...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28865204/diagnosis-of-caprine-arthritis-encephalitis-virus-infection-in-dairy-goats-by-elisa-pcr-and-viral-culture
#19
S Panneum, T Rukkwamsuk
For preventive and control strategies of Caprine Arthritis Encephalitis Virus (CAEV) infection in dairy goats, performance of the available diagnostic tests was described as one of the most important and necessary aspects. The study aimed at evaluating the diagnostic test performance, including PCR, ELISA and viral culture, for CAEV infection in dairy goats in Thailand. Blood samples of 29 dairy goats from five low- to medium-prevalence herds and one very low-prevalence herd were collected for PCR and ELISA methods...
March 1, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28860686/polyethylene-and-highly-cross-linked-polyethylene-for-cemented-total-hip-arthroplasty-a-comparison-of-over-ten-year-clinical-and-radiographic-results
#20
Tomotoshi Kawata, Koji Goto, Kazutaka So, Yutaka Kuroda, Shuichi Matsuda
INTRODUCTION: We investigated the long-term tribological outcomes of conventional polyethylene (CPE) and highly cross-linked polyethylene (HXLPE). METHODS: Ninety-four consecutive primary cemented THAs were performed using either HXLPE or CPE at our hospital. CPE sockets were used in 26 hips, and HXLPE sockets were implanted in 68 hips. RESULTS: A 10-year follow-up was completed for 69 cases. Linear wear rates of 0.138 ± 0.074 mm/year for CPE and 0...
December 2017: Journal of Orthopaedics
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