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https://www.readbyqxmd.com/read/27559996/effects-of-pluronic-f127-peg-multi-gel-core-on-the-release-profile-and-pharmacodynamics-of-exenatide-loaded-in-plga-microspheres
#1
Puxiu Wang, Qian Wang, Tianyang Ren, Haoyu Gong, Jingxin Gou, Yu Zhang, Cuifang Cai, Xing Tang
Pluronic F127 and PEG as a multi-gel-core were used to prepare Exenatide-loaded microspheres and store the drug within the microspheres. Also, the sol-gel transition and novel functions of the Pluronic F127-PEG gel core were investigated.Microspheres with a multi-gel-core (GCMs) and without a multi-gel-core (Ms) were compared in terms of the rate of PLGA degradation, therelease kinetics in vitro and the efficacy in KKAy mice. The drug release of GCMs was at a constant rate, and slower than Ms. In addition, after the KKAy mice were given Exenatide for 55days, the blood glucose concentration and HbA1c concentration in the GCMs group were lower than that in the Ms group...
November 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27470665/treatment-outcomes-and-tolerability-following-initiation-of-glp-1-receptor-agonists-among-type-2-diabetes-patients-in-primary-care-practices-in-germany
#2
Qing Qiao, Kristina Johnsson, Susan Grandy, Karel Kostev
BACKGROUND: The aim was to investigate real-world treatment outcomes and tolerability of GLP-1 receptor agonist (GLP-1RA) therapy in patients with type 2 diabetes in Germany. METHODS: Patients from 323 primary care practices who started any GLP-1RA therapy (89 Byetta, 108 Bydureon, 347 Victoza patients) between January 1, 2011, and December 31, 2013 (index date) were analyzed retrospectively (Disease Analyzer database, Germany). Changes from baseline in HbA1c, weight, and hypoglycemia were evaluated in 3 follow-up periods of 0-6, 7-12, and 13-18 months...
July 28, 2016: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/27418849/adherence-to-glp-1-receptor-agonist-therapy-administered-by-once-daily-or-once-weekly-injection-in-patients-with-type-2-diabetes-in-germany
#3
Qing Qiao, Mario Jnm Ouwens, Susan Grandy, Kristina Johnsson, Karel Kostev
AIM: This study aimed to compare 6-month adherence to therapy with exenatide once weekly (Bydureon(®)) vs liraglutide once daily (Victoza(®)) in patients with type 2 diabetes under primary care in Germany. METHODS: A nationwide longitudinal prescription database (LRx), (between January 2011 and September 2014) was used to analyze adherence to therapy. The proportion of days covered (PDC) by prescription was used as a measure of adherence in the 6-month postindex period...
2016: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/26071140/exenatide-extended-release-an-updated-review-of-its-use-in-type-2-diabetes-mellitus
#4
REVIEW
Yahiya Y Syed, Paul L McCormack
Exenatide extended-release (exenatide ER) [Bydureon(®)] is a glucagon-like peptide-1 receptor agonist, approved for the treatment of type 2 diabetes mellitus. It is injected subcutaneously by patients once weekly, with no dose titration required. This article updates an earlier review of exenatide ER in the management of type 2 diabetes, focusing on recently published data. In randomized, controlled trials, adjunctive exenatide ER 2 mg once weekly for 24-30 weeks significantly improved glycaemic control and reduced bodyweight in patients with inadequately controlled type 2 diabetes despite diet plus exercise and/or oral antihyperglycaemic drugs (OADs)...
July 2015: Drugs
https://www.readbyqxmd.com/read/25327373/-a-case-of-an-elderly-diabetic-patient-with-dementia-effectively-treated-with-weekly-exenatide
#5
Satoko Maruyama, Yuya Tsurutani, Mai Kondo, Naoko Sagawa, Akira Sata, Mariko Miyao, Yuzo Mizuno
A 74-year-old man with diabetes mellitus since 64 years of age had been treated with glimepiride, metformin and alogliptin; however, his glycemic control remained poor, i.e., a casual blood glucose level of 318 mg/dl, HbA1c level of 10.6% and glycated albumin level of 24.9%. Although his blood glucose level improved with intensive insulin therapy, he exhibited dementia with an MMSE score of 9/30 and was unable to continue insulin injections by himself, thus rejecting his family's help. The extended-release form of the GLP-1 agonist exenatide (Bydureon(®)) was recently introduced in Japan...
2014: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/24923102/-bydureon-first-once-weekly-glp-1-receptor-agonist-exenatide-lar
#6
COMPARATIVE STUDY
A J Scheen
Bydureon is a new galenic formulation (long-acting release) of exenatide, the first agonist of Glucagon-Like Peptide-1 (GLP-1) receptors having been commercialized for the management of type 2 diabetes. The microsphere technology permits a prolonged absorption of exenatide from the subcutaneous depot, which allows one injection per week instead of two injections per day with the initial formulation of exenatide (Byetta). The clinical development programme DURATION showed that exenatide 2 mg once weekly more markedly reduces glycated haemoglobin (HbA(1c)), with a similar weight loss but a better digestive tolerance profile (less nausea and vomiting after treatment initiation), compared with the twice daily 10 microg exenatide...
April 2014: Revue Médicale de Liège
https://www.readbyqxmd.com/read/24039406/long-acting-preparations-of-exenatide
#7
REVIEW
Yunpeng Cai, Liangming Wei, Liuqing Ma, Xiwen Huang, Anqi Tao, Zhenguo Liu, Weien Yuan
Exenatide has been widely used for the treatment of type 2 diabetes mellitus. However, its short plasma half-life of 2.4 hours has limited its clinical application. The exenatide products on the market, twice-daily Byetta™ and once-weekly Bydureon™ (both Amylin Pharmaceuticals, San Diego, CA, USA), are still not perfect. Many researchers have attempted to prolong the acting time of exenatide by preparing sustained-release dosage forms, modifying its structure, gene therapies, and other means. This review summarizes recent advances in long-acting exenatide preparations...
2013: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/23471935/an-evidence-based-and-practical-approach-to-using-bydureon%C3%A2-in-patients-with-type-2-diabetes
#8
Nathan A Painter, Candis M Morello, Renu F Singh, Sarah E McBane
Glucagon-like peptide (GLP)-1 agonists are one of the newer classes of medications for use in type 2 diabetes. There are currently three GLP-1 agonists on the market: exenatide twice daily, liraglutide, and exenatide extended release (ER). Exenatide ER is a new weekly formulation of exenatide. Exenatide ER reduces glycosylated hemoglobin by 1.6%, with fewer gastrointestinal side effects compared with twice-daily exenatide. Like other GLP-1 agonists, exenatide ER can be used in combination with metformin, sulfonylureas, or thiazolidinediones...
March 2013: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/22867046/exenatide-extended-release-a-review-of-its-use-in-type-2-diabetes-mellitus
#9
REVIEW
Lesley J Scott
Subcutaneous exenatide extended-release (ER; Bydureon™; also known as exenatide once weekly), a glucagon-like peptide-1 receptor agonist, provides a convenient, simple, once-weekly regimen that is approved in adult patients with type 2 diabetes as adjunctive monotherapy to diet plus exercise (in the US; not as first-line therapy) and/or as combination therapy with specific oral antihyperglycaemic drugs (OADs) in patients with inadequately controlled type 2 diabetes despite treatment with these OADs (US and Europe)...
August 20, 2012: Drugs
https://www.readbyqxmd.com/read/22789767/exenatide-for-once-weekly-administration
#10
COMPARATIVE STUDY
(no author information available yet)
▾Exenatide is a glucagon-like peptide 1 (GLP-1) agonist used in the management of people with type 2 diabetes. A twice-daily injectable formulation (▾Byetta - Eli Lilly) was licensed in 2006. ▾Bydureon (Eli Lilly) is a prolonged-release injectable formulation that allows once-weekly administration. Here we discuss the place of Bydureon in the management of type 2 diabetes mellitus.
July 2012: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/22421818/extended-release-exenatide-bydureon-for-type-2-diabetes
#11
(no author information available yet)
No abstract text is available yet for this article.
March 19, 2012: Medical Letter on Drugs and Therapeutics
https://www.readbyqxmd.com/read/22051096/the-role-of-glp-1-mimetics-and-basal-insulin-analogues-in-type-2-diabetes-mellitus-guidance-from-studies-of-liraglutide
#12
REVIEW
A H Barnett
In people with type 2 diabetes mellitus (T2DM), the incretin effect is reduced, but the recent advent of dipeptidyl peptidase-4 inhibitors and glucagon-like peptide (GLP)-1 agonists/analogues has enabled restoration of at least some of the function of the incretin system, with accompanying improvements in glycaemic control. Two GLP-1 receptor agonists/analogues are currently approved for the treatment of T2DM-exenatide (Byetta®, Eli Lilly & Co., Indianapolis, IN, US) and liraglutide (Victoza®, Novo Nordisk, Bagsvaerd, Denmark); a once-weekly formulation of exenatide (Bydureon®, Eli Lilly & Co...
April 2012: Diabetes, Obesity & Metabolism
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