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James W Morley, Rebecca L Selden, Robert J Latour, Thomas L Frölicher, Richard J Seagraves, Malin L Pinsky
Recent shifts in the geographic distribution of marine species have been linked to shifts in preferred thermal habitats. These shifts in distribution have already posed challenges for living marine resource management, and there is a strong need for projections of how species might be impacted by future changes in ocean temperatures during the 21st century. We modeled thermal habitat for 686 marine species in the Atlantic and Pacific oceans using long-term ecological survey data from the North American continental shelves...
2018: PloS One
Michiyuki Miyamoto, Kentaro Nakamura, Hideo Shichinohe, Tomohiro Yamauchi, Masaki Ito, Hisayasu Saito, Masahito Kawabori, Toshiya Osanai, Tasuku Sasaki, Kiyohiro Houkin, Satoshi Kuroda
Bone marrow stromal cell (BMSC) transplantation has the therapeutic potential for ischemic stroke. However, it is unclear which delivery routes would yield both safety and maximal therapeutic benefits. We assessed whether a novel recombinant peptide (RCP) sponge, that resembles human collagen, could act as a less invasive and beneficial scaffold in cell therapy for ischemic stroke. BMSCs from green fluorescent protein-transgenic rats were cultured and Sprague-Dawley rats were subjected to permanent middle cerebral artery occlusion (MCAo)...
2018: Stem Cells International
Xiaoying Yang, Rachel Warren, Yi He, Jinyin Ye, Qiaoling Li, Guoqing Wang
It is increasingly recognized that climate change could affect the quality of water through complex natural and anthropogenic mechanisms. Previous studies on climate change and water quality have mostly focused on assessing its impact on pollutant loads from agricultural runoff. A sub-daily SWAT model was developed to simulate the discharge, transport, and transformation of nitrogen from all known anthropogenic sources including industries, municipal sewage treatment plants, concentrated and scattered feedlot operations, rural households, and crop production in the Upper Huai River Basin...
February 15, 2018: Science of the Total Environment
Feng Guo, Li Yang, Jingfei Luo, Haiyan Quan, Zhen Wang, Hongyan Peng, Chenliang Hong, Jie Li, Zhisheng Jiang, Liang Zhang, Xuping Qin
Previous study suggested that the receptor component protein (RCP), one of the components of calcitonin gene-related peptide (CGRP) receptor, plays a multiple role in the cellular signal transduction. The study was designed to investigate whether or not the RCP involved in the regulation of caveolin-1/extracellular signal-regulated kinases-1 and -2 (ERK1/2) signal pathway in the vascular smooth muscle cells (VSMCs) proliferation induced by static pressure. Mouse-derived VSMCs line A10 (A10 VSMCs) was served as project in this experiment...
May 9, 2018: Journal of Cellular Physiology
Robert van Woesik, Christopher William Cacciapaglia
Coral reefs protect islands from tropical storm waves and provide goods and services for millions of islanders worldwide. Yet it is unknown how coral reefs in general, and carbonate production in particular, will respond to sea-level rise and thermal stress associated with climate change. This study compared the reef-building capacity of different shallow-water habitats at twenty-four sites on each of two islands, Palau and Yap, in the western Pacific Ocean. We were particularly interested in estimating the inverse problem of calculating the value of live coral cover at which net carbonate production becomes negative, and whether that value varied across habitats...
2018: PloS One
Mana Naritomi, Mitsuru Mizuno, Hisako Katano, Nobutake Ozeki, Koji Otabe, Keiichiro Komori, Shizuka Fujii, Shizuko Ichinose, Kunikazu Tsuji, Hideyuki Koga, Takeshi Muneta, Ichiro Sekiya
In vitro chondrogenesis of mesenchymal stem cells (MSCs) mimics in vivo chondrogenesis of MSCs. However, the size of the cartilage pellets that can be attained in vitro is limited by current methods; therefore, some modifications are required to obtain larger pellets. Petaloid pieces of recombinant peptide (petaloid RCP) have the advantage of creating spaces between cells in culture. The RCP used here is based on the alpha-1 sequence of human collagen type I and contains 12 Arg-Gly-Asp motifs. We examined the effect and mechanisms of adding petaloid RCP on the in vitro chondrogenesis of human synovial MSCs by culturing 125k cells with or without 0...
May 7, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Santanu Pakhira, Chandan Mazumdar, Dibyasree Choudhury, R Ranganathan, S Giri
In this work, we report the successful synthesis of a new intermetallic compound Dy2Ni0.87Si2.95 forming in single phase only with a chemically disordered structure. The random distribution of Ni/Si and crystal defects create a variation in the local electronic environment between the magnetic Dy ions. In the presence of both disorder and competing exchange interactions driven magnetic frustration, originating due to c/a ∼ 1, the compound undergoes spin freezing behaviour below 5.6 K. In the non-equilibrium state below the spin freezing behaviour, the compound exhibits aging phenomena and magnetic memory effects...
May 8, 2018: Physical Chemistry Chemical Physics: PCCP
Gehendra Kharel, Andrei Kirilenko
Background: Water level fluctuations in endorheic lakes are highly susceptible to even slight changes in climate and land use. Devils Lake (DL) in North Dakota, USA is an endorheic system that has undergone multi-decade flooding driven by changes in regional climate. Flooding mitigation strategies have centered on the release of lake water to a nearby river system through artificial outlets, resulting in legal challenges and environmental concerns related to water quality, downstream flooding, species migration, stakeholder opposition, and transboundary water conflicts between the US and Canada...
2018: PeerJ
Ibrahim Sultan, Valentino Bianco, Ibrahim Yajzi, Arman Kilic, Keith Dufendach, Arturo Cardounel, Andrew D Althouse, Ahmad Masri, Forozan Navid, Thomas G Gleason
BACKGROUND: Deep hypothermic circulatory arrest (DHCA) is often avoided in patients with concomitant ascending aortic pathology when treating other cardiac disease to avoid increased risk of morbidity and mortality. We hypothesized that the use of DHCA with retrograde cerebral perfusion (RCP) does not add incremental risk to ascending aortic replacement alone in the setting of concomitant cardiac surgery. METHODS: 408 ascending aortic ± hemiarch replacements and aortic (root)/mitral/tricuspid valve(s), CABG, or MAZE procedures were performed for concomitant cardiac disease...
May 3, 2018: Annals of Thoracic Surgery
Pablo H Vigliano, Magalí M Rechencq, María V Fernández, Gustavo E Lippolt, Patricio J Macchi
Habitat use in relation to the thermal habitat availability and food source as a forcing factor on habitat selection and use of Percichthys trucha (Creole perch), Oncorhynchus mykiss (rainbow trout), Salmo trutta (brown trout) and Salvelinus fontinalis (brook trout) were determined as well as future potential thermal habitat availability for these species under climate change scenarios Representative Concentration Pathways 4.5 and 8.5. This study was conducted in three interconnected lakes of Northern Patagonia (Moreno Lake system)...
May 1, 2018: Science of the Total Environment
Yin Bo Zhang, Chen Hong Gao, Hao Qin
Understanding the responses of the habitats of endangered species to climate change is of great significance for biodiversity conservation and the maintenance of the integrity of ecosystem function. In this study, the potential suitable distribution habitats of Elaeagnus mollis in Shanxi Province was simulated by the maximum entropy model, based on 73 occurrence field records and 35 environmental factors under the current climate condition. Moreover, with the Fifth Assessment Report of Intergovernmental Panel on Climate Change, the dynamics of distribution pattern was analyzed for E...
April 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
Michael Bornholdt, Kayla Woelfel, Ping Fang, Mark Jacobson, Joseph Hung
The objective of this study was to develop instant thin layer chromatography (ITLC) conditions for the determination of radiochemical purity (RCP) of 68 Ga-DOTATATE in a shorter time period than those stated in the NETSPOT (Advanced Accelerator Applications, Saint-Genis-Pouilly, France; AAA) kit package insert (PI). A faster ITLC system is needed to reduce the current 48-50 minutes development time; so that (1) more radioactivity is available for single patient use as the generator ages and (2) wait times are shorter in the event of kit failure...
May 3, 2018: Journal of Nuclear Medicine Technology
Josep M Serra-Diaz, Charles Maxwell, Melissa S Lucash, Robert M Scheller, Danelle M Laflower, Adam D Miller, Alan J Tepley, Howard E Epstein, Kristina J Anderson-Teixeira, Jonathan R Thompson
The impacts of climatic changes on forests may appear gradually on time scales of years to centuries due to the long generation times of trees. Consequently, current forest extent may not reflect current climatic patterns. In contrast with these lagged responses, abrupt transitions in forests under climate change may occur in environments where alternative vegetation states are influenced by disturbances, such as fire. The Klamath forest landscape (northern California and southwest Oregon, USA) is currently dominated by high biomass, biodiverse temperate coniferous forests, but climate change could disrupt the mechanisms promoting forest stability (e...
April 30, 2018: Scientific Reports
Palash Sinha, Michael E Mann, Jose D Fuentes, Alfonso Mejia, Liang Ning, Weiyi Sun, Tao He, Jayantha Obeysekera
We make future projections of seasonal precipitation characteristics in southern Florida using a statistical downscaling approach based on Self Organized Maps. Our approach is applied separately to each three-month season: September-November; December-February; March-May; and June-August. We make use of 19 different simulations from the Coupled Model Inter-comparison Project, phase 5 (CMIP5) and generate an ensemble of 1500 independent daily precipitation surrogates for each model simulation, yielding a grand ensemble of 28,500 total realizations for each season...
April 20, 2018: Science of the Total Environment
Mario Gaudino, Natalia Ivascu, Melissa Cushing, Christopher Lau, Ivancarmine Gambardella, Antonino Di Franco, Lucas B Ohmes, Monica Munjal, Leonard N Girardi
Background: The optimal technique for brain perfusion during circulatory arrest remains controversial. Concern exists that retrograde cerebral perfusion (RCP) via the superior vena cava (SVC) is unable to perfuse the brain. We evaluated whether RCP blood circulates through the brain parenchyma in humans during deep hypothermic circulatory arrest (DHCA). We hypothesized that a significant difference in the levels of S-100β (a protein with very high neuro-sensitivity) between the blood infused in the SVC and the effluent blood returning in the left carotid artery (CA) during RCP, should be regarded as a sign of the circulation of RCP blood through the brain parenchyma...
March 2018: Journal of Thoracic Disease
So Ra Choe, Yu Na Kim, Chang Gyo Park, Kyung Hwa Cho, Do Yeun Cho, Hoi Young Lee
Rab coupling protein (RCP) aggravates cancer cell metastasis and has been implicated in various cancer patient outcomes. Recently, we showed that RCP induces Slug expression and cancer cell invasion by stabilizing the β1 integrin protein. In the present study, we demonstrated that FAK is implicated in RCP-induced EGFR phosphorylation and ovarian cancer cell invasion with inhibition by curcumin. Ectopic expression of RCP induced FAK phosphorylation, which links β1 integrin with EGFR and participates in a positive regulation loop with EGFR...
April 27, 2018: Experimental & Molecular Medicine
Hongbo Huang, Ke Li, Gaochao Lv, Guiqing Liu, Xueyu Zhao, Qingzhu Liu, Shanshan Wang, Xi Li, Ling Qiu, Jianguo Lin
Positron emission tomography (PET) imaging is a useful method to evaluate in situ estrogen receptor (ER) status for the early diagnosis of breast cancer and optimization of the appropriate treatment strategy. The 18 F-labeled estradiol derivative has been successfully used to clinically assess the ER level of breast cancer. In order to simplify the radiosynthesis process, one-step 18 F-19 F isotope exchange reaction was employed for the 18 F-fluorination of the tracer of [ 18 F]AmBF 3 -TEG-ES . The radiotracer was obtained with the radiochemical yield (RCY) of ~61% and the radiochemical purity (RCP) of >98% within 40 min...
2018: Contrast Media & Molecular Imaging
Jae Young Lee, Ejin Kim, Woo-Seop Lee, Yeora Chae, Ho Kim
The Paris Agreement aims to limit the global temperature increase to below 2 °C above pre-industrial levels and to pursue efforts to limit the increase to even below 1.5 °C. Now, it should be asked what benefits are in pursuing these two targets. In this study, we assessed the temperature⁻mortality relationship using a distributed lag non-linear model in seven major cities of South Korea. Then, we projected future temperature-attributable mortality under different Representative Concentration Pathway (RCP) and Shared Socioeconomic Pathway (SSP) scenarios for those cities...
April 21, 2018: International Journal of Environmental Research and Public Health
Akiko Tanaka, Anthony L Estrera
Cerebral complication is a major concern after aortic arch surgery, which may lead to death. Thus, cerebral protection strategy plays the key role to obtain respectable results in aortic arch repair. Deep hypothermic circulatory arrest was introduced in 1970s to decrease the ischemic insults to the brain. However, safe duration of circulatory arrest time was limited to 30 minutes. The 1990s was the decade of evolution for cerebral protection, in which two adjuncts for deep hypothermic circulatory arrest were introduced: retrograde and antegrade cerebral perfusion (ACP) techniques...
2018: Journal of Visualized Surgery
Qi Zhao, Shanshan Li, Wei Cao, De-Li Liu, Quan Qian, Hongyan Ren, Fan Ding, Gail Williams, Rachel Huxley, Wenyi Zhang, Yuming Guo
BACKGROUND: There is limited evidence about the association between ambient temperature and the incidence of pediatric hand, foot, and mouth disease (HFMD) nationwide in China. OBJECTIVES: We examined the childhood temperature-HFMD associations across mainland China, and we projected the change in HFMD cases due to projected temperature change by the 2090s. METHODS: Data on daily HFMD (children 0-14 y old) counts and weather were collected from 362 sites during 2009-2014...
April 20, 2018: Environmental Health Perspectives
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