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https://www.readbyqxmd.com/read/28922401/rab11-family-expression-in-the-human-placenta-localization-at-the-maternal-fetal-interface
#1
Elizabeth S Taglauer, Patrycja A Artemiuk, Sara R Hanscom, Andrew J Lindsay, Danielle Wuebbolt, Fionnuala M Breathnach, Elizabeth C Tully, Amir R Khan, Mary W McCaffrey
Rab proteins are a family of small GTPases involved in a variety of cellular processes. The Rab11 subfamily in particular directs key steps of intracellular functions involving vesicle trafficking of the endosomal recycling pathway. This Rab subfamily works through a series of effector proteins including the Rab11-FIPs (Rab11 Family-Interacting Proteins). While the Rab11 subfamily has been well characterized at the cellular level, its function within human organ systems is still being explored. In an effort to further study these proteins, we conducted a preliminary investigation of a subgroup of endosomal Rab proteins in a range of human cell lines by Western blotting...
2017: PloS One
https://www.readbyqxmd.com/read/28921398/preliminary-analysis-of-numerical-chromosome-abnormalities-in-reciprocal-and-robertsonian-translocation-preimplantation-genetic-diagnosis-cases-with-24-chromosomal-analysis-with-an-acgh-snp-microarray
#2
Yanxin Xie, Yanwen Xu, Jing Wang, Benyu Miao, Yanhong Zeng, Chenhui Ding, Jun Gao, Canquan Zhou
PURPOSE: The aim of this study was to determine whether an interchromosomal effect (ICE) occurred in embryos obtained from reciprocal translocation (rcp) and Robertsonian translocation (RT) carriers who were following a preimplantation genetic diagnosis (PGD) with whole chromosome screening with an aCGH and SNP microarray. We also analyzed the chromosomal numerical abnormalities in embryos with aneuploidy in parental chromosomes that were not involved with a translocation and balanced in involved parental translocation chromosomes...
September 18, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28905897/impact-of-a-global-temperature-rise-of-1-5-degrees-celsius-on-asia-s-glaciers
#3
P D A Kraaijenbrink, M F P Bierkens, A F Lutz, W W Immerzeel
Glaciers in the high mountains of Asia (HMA) make a substantial contribution to the water supply of millions of people, and they are retreating and losing mass as a result of anthropogenic climate change at similar rates to those seen elsewhere. In the Paris Agreement of 2015, 195 nations agreed on the aspiration to limit the level of global temperature rise to 1.5 degrees Celsius ( °C) above pre-industrial levels. However, it is not known what an increase of 1.5 °C would mean for the glaciers in HMA...
September 13, 2017: Nature
https://www.readbyqxmd.com/read/28905308/an-automated-multidose-synthesis-of-the-potentiometric-pet-probe-4-18-f-fluorobenzyl-triphenylphosphonium-18-f-fbntp
#4
Christopher M Waldmann, Adrian Gomez, Phillip Marchis, Sean T Bailey, Milica Momcilovic, Anthony E Jones, David B Shackelford, Saman Sadeghi
PURPOSE: The aim of this study was the automated synthesis of the mitochondrial membrane potential sensor 4-[(18)F]fluorobenzyl-triphenylphosphonium ([(18)F]FBnTP) on a commercially available synthesizer in activity yields (AY) that allow for imaging of multiple patients. PROCEDURES: A three-pot, four-step synthesis was implemented on the ELIXYS FLEX/CHEM radiosynthesizer (Sofie Biosciences) and optimized for radiochemical yield (RCY), radiochemical purity (RCP) as well as chemical purity during several production runs (n = 24)...
September 13, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28901542/effects-of-response-contingent-stimulus-pairing-on-vocalizations-of-nonverbal-children-with-autism
#5
Tracy L Lepper, Anna Ingeborg Petursdottir
Research on stimulus-stimulus pairing to induce novel vocalizations in nonverbal children has typically employed response-independent pairing (RIP) procedures to condition speech sounds as reinforcers. The purpose of the present study was to evaluate the effects of a response-contingent pairing (RCP) procedure on the vocalizations of three nonverbal boys diagnosed with autism spectrum disorder. During RCP, adult-delivered sounds that were either paired with a preferred item (target sounds) or not (nontarget sounds) were presented contingent on a button-press response...
September 13, 2017: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/28894099/statistical-modelling-predicts-almost-complete-loss-of-major-periglacial-processes-in-northern-europe-by-2100
#6
Juha Aalto, Stephan Harrison, Miska Luoto
The periglacial realm is a major part of the cryosphere, covering a quarter of Earth's land surface. Cryogenic land surface processes (LSPs) control landscape development, ecosystem functioning and climate through biogeochemical feedbacks, but their response to contemporary climate change is unclear. Here, by statistically modelling the current and future distributions of four major LSPs unique to periglacial regions at fine scale, we show fundamental changes in the periglacial climate realm are inevitable with future climate change...
September 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28888269/depression-is-associated-with-recurrent-chest-pain-with-or-without-coronary-artery-disease-a-prospective-cohort-study-in-the-emergency-department
#7
Yeunjung Kim, Morgan Soffler, Summer Paradise, Qurat-Ul-Ain Jelani, James Dziura, Rajita Sinha, Basmah Safdar
BACKGROUND: Only a small fraction of acute chest pain in the emergency department (ED) is due to obstructive coronary artery disease (CAD). ED chest pain remains associated with high rates of recidivism, often in the presence of nonobstructive CAD. Psychological states such as depression, anxiety, and elevation of perceived stress may account for this finding. The objective of the study was to determine whether psychological states predict recurrent chest pain (RCP). METHODS: We conducted a prospective cohort study of low- to moderate-cardiac risk ED patients admitted to the Yale Chest Pain Center with acute chest pain...
September 2017: American Heart Journal
https://www.readbyqxmd.com/read/28887895/impact-of-climate-change-on-vector-transmission-of-trypanosoma-cruzi-chagas-1909-in-north-america
#8
O Carmona-Castro, D A Moo-Llanes, J M Ramsey
Climate change can influence the geographical range of the ecological niche of pathogens by altering biotic interactions with vectors and reservoirs. The distributions of 20 epidemiologically important triatomine species in North America were modelled, comparing the genetic algorithm for rule-set prediction (GARP) and maximum entropy (MaxEnt), with or without topographical variables. Potential shifts in transmission niche for Trypanosoma cruzi (Trypanosomatida: Trypanosomatidae) (Chagas, 1909) were analysed for 2050 and 2070 in Representative Concentration Pathway (RCP) 4...
September 9, 2017: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/28878694/physiological-responses-to-firefighting-in-extreme-temperatures-do-not-compare-to-firefighting-in-temperate-conditions
#9
Stephanie Windisch, Wolfgang Seiberl, Daniel Hahn, Ansgar Schwirtz
Purpose: The aim of this study was to examine physiological responses to two different simulated firefighting exercises: a firefighting exercise with flashovers, smoke, poor visibility and extreme temperatures (300°) in a burning container and a standard firefighting exercise in temperate conditions. Furthermore, a second purpose of the study was to find out if the contribution of strength and endurance capacities to firefighting performance changes when the demands of the firefighting exercise change. Methods: Sixteen professional firefighters performed a maximum treadmill test, strength testing, a standard simulated firefighting exercise (SFE) without heat and flashovers and a firefighting exercise with a simulation of the flashover phenomenon in a burning container (FOT)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28870188/assessing-the-impact-of-the-introduction-of-an-electronic-hospital-discharge-system-on-the-completeness-and-timeliness-of-discharge-communication-a-before-and-after-study
#10
Rajnikant L Mehta, Bryn Baxendale, Katie Roth, Victoria Caswell, Ivan Le Jeune, Jack Hawkins, Haya Zedan, Anthony J Avery
BACKGROUND: Hospital discharge summaries are a key communication tool ensuring continuity of care between primary and secondary care. Incomplete or untimely communication of information increases risk of hospital readmission and associated complications. The aim of this study was to evaluate whether the introduction of a new electronic discharge system (NewEDS) was associated with improvements in the completeness and timeliness of discharge information, in Nottingham University Hospitals NHS Trust, England...
September 5, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28844545/the-risk-of-neurological-dysfunctions-after-deep-hypothermic-circulatory-arrest-with-retrograde-cerebral-perfusion
#11
Giuseppe Gatti, Bernardo Benussi, Placido Currò, Gabriella Forti, Elisabetta Rauber, Alessandro Minati, Marco Gabrielli, Umberto Tognolli, Gianfranco Sinagra, Aniello Pappalardo
OBJECTIVE: Retrograde cerebral perfusion (RCP) is a brain protection technique that is adopted generally for anticipated short periods of deep hypothermic circulatory arrest (DHCA). However, the real impact of this technique on cerebral protection during DHCA remains a controversial issue. METHODS: For 344 (59.5%) of 578 consecutive patients (mean age, 66.9 ± 10.9 years) who underwent cardiovascular surgery under DHCA at the present authors' institution (1999-2015), RCP was the sole technique of cerebral protection that was adopted in addition to deep hypothermia...
August 22, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28838335/comparative-determination-of-ventilatory-efficiency-from-constant-load-and-incremental-exercise-testing
#12
S Algul, F A Ugur, A Ayar, O Ozcelik
The analysis of the relationships between minute ventilation (VE) to CO2 output (VCO2), referred to as ventilatory efficiency, in response to incremental exercise testing, is considered a useful index for assessing the presence and severity of cardiopulmonary and metabolic diseases. The effects of constant load exercise testing performed at work intensity associated with anaerobic threshold (AT) and respiratory compensation points (RCP), on the accurate measurements of ventilatory efficiency are not well known...
August 15, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28835959/-alcl3-bnme2-tacn-a-new-metal-chelate-scaffold-for-radiofluorination-by-cl-f-exchange
#13
William Levason, Sajinder K Luthra, Graeme McRobbie, Francesco M Monzittu, Gillian Reid
Radiofluorination of a 2.63 μM solution (pH 4, NaOAc buffer) of [AlCl3(BnMe2-tacn)] via treatment with 2.99 mol. equiv. of [(19)F]KF doped with cyclotron-produced [(18)F]F(-) target water, with heating to 80-100 °C for 1 h, gives up to 24% (18)F incorporation. SPE purification of the [Al(19)F2(18)F(BnMe2-tacn)] radio-product gives >99% RCP, with excellent stability (>99% RCP after 3 h).
August 24, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28831145/projecting-potential-distribution-of-eucryptorrhynchus-scrobiculatus-motschulsky-and-e-brandti-harold-under-historical-climate-and-rcp-8-5-scenario
#14
Yingchao Ji, Wen Luo, Ganyu Zhang, Junbao Wen
Ailanthus altissima (Mill.) Swingle and its variant A. altissima var. Qiantouchun are notorious invasive weeds. Two weevils, Eucryptorrhynchus scrobiculatus (ESC) and E. brandti (EBR) are considered as candidates for biological control of A. altissima. The aim of this study was to model the potential distributions of ESC and EBR using CLIMEX 4.0. The projected potential distributions of ESC and EBR included almost all current distribution areas of A. altissima, except Southeast Asia. Under historical climate, potential distribution area of EBR is larger than that of ESC, 46...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28827086/risk-factors-for-erectile-dysfunction-in-men-with-htlv-1
#15
Cassius José Vitor de Oliveira, José Abraão Carneiro Neto, Rosana C P Andrade, Paulo Novis Rocha, Edgar Marcelino de Carvalho Filho
BACKGROUND: Erectile dysfunction (ED) occurs in more than 50% of patients with human T-cell lymphotropic virus type 1 (HTLV-1) infection. In the general population, atherosclerosis is the main risk factor related to ED. AIM: To compare the contribution of neurologic disorders from HTLV-1 with that of atherosclerosis as risk factors for ED in men with HTLV-1. METHODS: In this cross-sectional study, men 18 to 70 years old with HTLV-1 were classified into one of two groups according to the presence or absence of ED...
August 18, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28813037/concomitant-bladder-cancer-and-prostate-cancer-challenges-and-controversies
#16
REVIEW
Antonio Lopez-Beltran, Liang Cheng, Francesco Montorsi, Maria Scarpelli, Maria R Raspollini, Rodolfo Montironi
Radical cystoprostatectomy (RCP) followed by bilateral pelvic lymphadenectomy and urinary diversion remains the gold-standard therapy for men with localized muscle-invasive bladder cancer (MIBC). Prostate cancer might be incidentally detected at the time of RCP with a reported prevalence of 24-51%. Typically, these patients are considered to have clinically insignificant disease, but data from emerging series challenge this assumption and suggest that some of these tumours might be aggressive, or somehow increase the aggressiveness of the associated MIBC, and can negatively influence the patient's overall survival outcomes...
August 16, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28808651/evaluation-of-acute-aortic-dissection-type-a-factors-and-comparison-the-postoperative-clinical-outcomes-between-two-surgical-methods
#17
Hasan Shemirani, Amir Mirmohamadsadeghi, Behzad Mahaki, Sadaf Farhadi, Reza Mohseni Badalabadi, Peyman Bidram, Mehdi Mohseni Badalabadi
BACKGROUND: Although aortic dissection is a rare disease, it causes high level of mortality. If ascending aorta gets involved in this disease, it is known as type A. According to small number of studies about this disease in Iran, this study conducted to detect the factors related to acute aortic dissection type A, its surgery consequences and the factors affecting them. MATERIALS AND METHODS: In this historical cohort study, all patients having acute aortic dissection type A referring to Chamran Hospital from 2006 to 2012 were studied...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28806544/decadal-analysis-of-impact-of-future-climate-on-wheat-production-in-dry-mediterranean-environment-a-case-of-jordan
#18
Prakash N Dixit, Roberto Telleria, Amal N Al Khatib, Siham F Allouzi
Different aspects of climate change, such as increased temperature, changed rainfall and higher atmospheric CO2 concentration, all have different effects on crop yields. Process-based crop models are the most widely used tools for estimating future crop yield responses to climate change. We applied APSIM crop simulation model in a dry Mediterranean climate with Jordan as sentinel site to assess impact of climate change on wheat production at decadal level considering two climate change scenarios of representative concentration pathways (RCP) viz...
August 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28797067/potential-distribution-of-pine-wilt-disease-under-future-climate-change-scenarios
#19
Akiko Hirata, Katsunori Nakamura, Katsuhiro Nakao, Yuji Kominami, Nobuyuki Tanaka, Haruka Ohashi, Kohei Takenaka Takano, Wataru Takeuchi, Tetsuya Matsui
Pine wilt disease (PWD) constitutes a serious threat to pine forests. Since development depends on temperature and drought, there is a concern that future climate change could lead to the spread of PWD infections. We evaluated the risk of PWD in 21 susceptible Pinus species on a global scale. The MB index, which represents the sum of the difference between the mean monthly temperature and 15 when the mean monthly temperatures exceeds 15°C, was used to determine current and future regions vulnerable to PWD (MB ≥ 22)...
2017: PloS One
https://www.readbyqxmd.com/read/28753605/spatiotemporal-analysis-of-projected-impacts-of-climate-change-on-the-major-c3-and-c4-crop-yield-under-representative-concentration-pathway-4-5-insight-from-the-coasts-of-tamil-nadu-south-india
#20
Ramachandran A, Dhanya Praveen, Jaganathan R, RajaLakshmi D, Palanivelu K
India's dependence on a climate sensitive sector like agriculture makes it highly vulnerable to its impacts. However, agriculture is highly heterogeneous across the country owing to regional disparities in exposure, sensitivity, and adaptive capacity. It is essential to know and quantify the possible impacts of changes in climate on crop yield for successful agricultural management and planning at a local scale. The Hadley Centre Global Environment Model version 2-Earth System (HadGEM-ES) was employed to generate regional climate projections for the study area using the Regional Climate Model (RCM) RegCM4...
2017: PloS One
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