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https://www.readbyqxmd.com/read/29139598/preparation-and-comparative-evaluation-of-99m-tc-hynic-cngr-and-99m-tc-hynic-peg2-cngr-as-tumor-targeting-molecular-imaging-probes
#1
Kusum Vats, Drishty Satpati, Rohit Sharma, Chandan Kumar, Haladhar Dev Sarma, Sharmila Banerjee
The tripeptide sequence NGR (asparagine-glycine-arginine) specifically recognizes aminopeptidase N (APN or CD13) receptors highly expressed on tumor cells as well as tumor vasculature. Thus NGR peptides can precisely deliver therapeutic and diagnostic compounds to CD13 expressing cancer sites. In this regard two NGR peptide ligands, HYNIC-c(NGR) and HYNIC-PEG2 -c(NGR) were synthesized, radiolabeled with (99m) Tc and evaluated in CD13-positive human fibrosarcoma HT-1080 tumor xenografts. The radiotracers, (99m) Tc-HYNIC-c(NGR) and (99m) Tc-HYNIC-PEG2 -c(NGR) could be prepared in ~95% radiochemical purity (RCP) and exhibited excellent in vitro and in vivo stability...
November 15, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29135786/are-rcp-and-critical-power-equivalent-the-issue-of-mean-response-time
#2
Jan Boone, Jan G Bourgois
No abstract text is available yet for this article.
December 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29134196/environmental-controls-on-modern-scleractinian-coral-and-reef-scale-calcification
#3
Travis A Courtney, Mario Lebrato, Nicholas R Bates, Andrew Collins, Samantha J de Putron, Rebecca Garley, Rod Johnson, Juan-Carlos Molinero, Timothy J Noyes, Christopher L Sabine, Andreas J Andersson
Modern reef-building corals sustain a wide range of ecosystem services because of their ability to build calcium carbonate reef systems. The influence of environmental variables on coral calcification rates has been extensively studied, but our understanding of their relative importance is limited by the absence of in situ observations and the ability to decouple the interactions between different properties. We show that temperature is the primary driver of coral colony (Porites astreoides and Diploria labyrinthiformis) and reef-scale calcification rates over a 2-year monitoring period from the Bermuda coral reef...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29107996/epigenetic-memory-via-concordant-dna-methylation-is-inversely-correlated-to-developmental-potential-of-mammalian-cells
#4
Minseung Choi, Diane P Genereux, Jamie Goodson, Haneen Al-Azzawi, Shannon Q Allain, Noah Simon, Stan Palasek, Carol B Ware, Chris Cavanaugh, Daniel G Miller, Winslow C Johnson, Kevin D Sinclair, Reinhard Stöger, Charles D Laird
In storing and transmitting epigenetic information, organisms must balance the need to maintain information about past conditions with the capacity to respond to information in their current and future environments. Some of this information is encoded by DNA methylation, which can be transmitted with variable fidelity from parent to daughter strand. High fidelity confers strong pattern matching between the strands of individual DNA molecules and thus pattern stability over rounds of DNA replication; lower fidelity confers reduced pattern matching, and thus greater flexibility...
November 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29103648/adapting-crop-rotations-to-climate-change-in-regional-impact-modelling-assessments
#5
Edmar I Teixeira, John de Ruiter, Anne-Gaelle Ausseil, Adam Daigneault, Paul Johnstone, Allister Holmes, Andrew Tait, Frank Ewert
The environmental and economic sustainability of future cropping systems depends on adaptation to climate change. Adaptation studies commonly rely on agricultural systems models to integrate multiple components of production systems such as crops, weather, soil and farmers' management decisions. Previous adaptation studies have mostly focused on isolated monocultures. However, in many agricultural regions worldwide, multi-crop rotations better represent local production systems. It is unclear how adaptation interventions influence crops grown in sequences...
November 2, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29101304/functional-role-of-a-novel-long-noncoding-rna-ttn-as1-in-esophageal-squamous-cell-carcinoma-progression-and-metastasis
#6
Chenyu Lin, Nan Zhang, Ying Wang, Yuanshu Wang, Changying Guo, Edouard Nice, Erhao Zhang, Liting Yu, Mengwei Zhang, Chen Liu, Lirong Hu, Jingchao Hao, Weiyan Qi, Hanmei Xu
PURPOSE: Emerging studies demonstrate that long non-coding RNAs (lncRNAs)participate in the regulation of various cancers. In the current study, a novel lncRNA-TTN-AS1 has been identified and explored in esophageal squamous cell carcinoma (ESCC). EXPERIMENTAL DESIGN: To discover a new regulatory circuitry in which RNAs crosstalk with each other, the transcriptome of lncRNA-miRNA-mRNA from ESCC and adjacent non-malignant specimens were analyzed using multiple microarrays and diverse bioinformatics platforms...
November 3, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29100641/retrograde-cerebral-perfusion-is-effective-for-prolonged-circulatory-arrest-in-arch-aneurysm-repair
#7
Christopher Lau, Mario Gaudino, Erin Mills Iannacone, Ivancarmine Gambardella, Monica Munjal, Lucas B Ohmes, Benjamin C Degner, Leonard N Girardi
BACKGROUND: The optimal brain protection strategy for prolonged periods of circulatory arrest is still controversial. This study evaluated whether retrograde cerebral perfusion (RCP) provides adequate brain protection for prolonged periods of deep hypothermic circulatory arrest (DHCA). METHODS: From January 1997 to December 2014, 1,043 patients underwent aortic arch operations using RCP and DHCA at 18°C. The DHCA time for 993 patients was 49 minutes or less and the DHCA time for the remaining 50 patients was 50 minutes or more...
November 1, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29080092/efficacy-of-modified-less-invasive-quick-replacement-using-mild-hypothermic-arrest-and-partial-retrograde-cerebral-perfusion-for-type-a-acute-aortic-dissection
#8
Mitsumasa Hata, Yukihiko Orime, Shinji Wakui, Tomofumi Umeda, Kenji Akiyama, Masashi Tanaka
OBJECTIVE: We previously reported a unique technique called "less invasive quick replacement (LIQR)" for treating type A acute aortic dissection with moderate hypothermic arrest (28 °C). This study examines the modified LIQR using mild hypothermic arrest (30 °C) with partial retrograde cerebral perfusion (RCP). METHODS: 187 patients were divided into 2 groups: group L consisted of 130 patients underwent LIQR without any cerebral perfusion; group M consisted of 57 patients who were treated with modified LIQR...
October 27, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29079876/predicting-the-patterns-of-change-in-spring-onset-and-false-springs-in-china-during-the-twenty-first-century
#9
Likai Zhu, Jijun Meng, Feng Li, Nanshan You
Spring onset has generally shifted earlier in China over the past several decades in response to the warming climate. However, future changes in spring onset and false springs, which will have profound effects on ecosystems, are still not well understood. Here, we used the extended form of the Spring Indices model (SI-x) to project changes in the first leaf and first bloom dates, and predicted false springs for the historical (1950-2005) and future (2006-2100) periods based on the downscaled daily maximum/minimum temperatures under two emission scenarios from 21 General Circulation Models (GCMs) of the Coupled Model Intercomparison Project Phase 5 (CMIP5)...
October 28, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29059569/analysis-and-modelling-of-surface-urban-heat-island-in-20-canadian-cities-under-climate-and-land-cover-change
#10
Abhishek Gaur, Markus Kalev Eichenbaum, Slobodan P Simonovic
Surface Urban Heat Island (SUHI) is an urban climate phenomenon that is expected to respond to future climate and land-use land-cover change. It is important to further our understanding of physical mechanisms that govern SUHI phenomenon to enhance our ability to model future SUHI characteristics under changing geophysical conditions. In this study, SUHI phenomenon is quantified and modelled at 20 cities distributed across Canada. By analyzing MODerate Resolution Imaging Spectroradiometer (MODIS) sensed surface temperature at the cities over 2002-2012, it is found that 16 out of 20 selected cities have experienced a positive SUHI phenomenon while 4 cities located in the prairies region and high elevation locations have experienced a negative SUHI phenomenon in the past...
October 20, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29028682/current-and-projected-burden-of-disease-from-high-ambient-temperature-in-korea
#11
Soo Eun Chung, Hae-Kwan Cheong, Jae-Hyun Park, Jong-Hun Kim, Hyunjin Han
BACKGROUND: The objective of the present study was to estimate the current and projected burden of disease from high ambient temperature using population-based data sources of nationwide mortality and morbidity in Korea. METHODS: Disability-adjusted life years (DALY) were estimated using noninjury-related deaths, and cerebrovascular and cardiovascular diseases from recently released nationwide health and mortality databases. Years of life lost and years lost due to disability were measured based on the point prevalence and number of deaths during the study period...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29019814/the-optimization-of-the-prevascularization-procedures-for-improving-subcutaneous-islet-engraftment
#12
Satomi Suzuki Uematsu, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Yasuhiro Igarashi, Ibrahim Fathi, Shigehito Miyagi, Noriaki Ohuchi, Susumu Satomi, Masafumi Goto
BACKGROUND: Subcutaneous islet transplantation (SC Tx) is associated with minimal invasiveness, but poor vascularization. Thus, the optimization of the prevascularization procedures is crucial for improving the outcomes. Although the effectiveness of basic fibroblast growth factor (bFGF) was reported, the optimal procedures remain unclear. We sought to optimize the prevascularization procedures including the use of a novel scaffold, recombinant peptide (RCP). METHODS: Devices containing various amount of bFGF with/without heparin, or RCP were implanted into the subcutaneous space of diabetic C57BL/6 mice...
October 10, 2017: Transplantation
https://www.readbyqxmd.com/read/29017986/environmental-suitability-of-vibrio-infections-in-a-warming-climate-an-early-warning-system
#13
Jan C Semenza, Joaquin Trinanes, Wolfgang Lohr, Bertrand Sudre, Margareta Löfdahl, Jaime Martinez-Urtaza, Gordon L Nichols, Joacim Rocklöv
BACKGROUND: Some Vibrio spp. are pathogenic and ubiquitous in marine waters with low to moderate salinity and thrive with elevated sea surface temperature (SST). OBJECTIVES: Our objective was to monitor and project the suitability of marine conditions for Vibrio infections under climate change scenarios. METHODS: The European Centre for Disease Prevention and Control (ECDC) developed a platform (the ECDC Vibrio Map Viewer) to monitor the environmental suitability of coastal waters for Vibrio spp...
October 10, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29017551/comparative-efficacy-of-the-leucofeligen%C3%A2-felv-rcp-and-purevax%C3%A2-rcp-felv-vaccines-against-infection-with-circulating-feline-calicivirus
#14
T Almeras, P Schreiber, S Fournel, V Martin, C S Nicolas, C Fontaine, C Lesbros, S Gueguen
BACKGROUND: Feline calicivirus (FCV) is a common virus, found worldwide, mainly responsible for chronic ulceroproliferative faucitis and periodontitis. This virus has a high mutation rate, leading to the presence of numerous FCV strains in the field. The objectives of this study was to evaluate and compare the efficacy of two vaccines (Leucofeligen™ FeLV/RCP and Purevax™ RCP FeLV), which differ by their nature (live vs. inactivated) and the vaccinal strains, against circulating FCV strains...
October 10, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28994890/errors-in-preparation-and-administration-of-parenteral-drugs-in-neonatology-evaluation-and-corrective-actions
#15
Nesrine Hasni, Emira Ben Hamida, Khouloud Ben Jeddou, Sarra Ben Hamida, Imene Ayadi, Zeineb Ouahchi, Zahra Marrakchi
BACKGROUND: The medication iatrogenic risk is quite unevaluated in neonatology Objective: Assessment of errors that occurred during the preparation and administration of injectable medicines in a neonatal unit in order to implement corrective actions to reduce the occurrence of these errors. METHODS: A prospective, observational study was performed in a neonatal unit over a period of one month. The practice of preparing and administering injectable medications were identified through a standardized data collection form...
December 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28989942/diagnosing-phosphorus-limitations-in-natural-terrestrial-ecosystems-in-carbon-cycle-models
#16
Yan Sun, Shushi Peng, Daniel S Goll, Philippe Ciais, Bertrand Guenet, Matthieu Guimberteau, Philippe Hinsinger, Ivan A Janssens, Josep Peñuelas, Shilong Piao, Benjamin Poulter, Aurélie Violette, Xiaojuan Yang, Yi Yin, Hui Zeng
Most of the Earth System Models (ESMs) project increases in net primary productivity (NPP) and terrestrial carbon (C) storage during the 21st century. Despite empirical evidence that limited availability of phosphorus (P) may limit the response of NPP to increasing atmospheric CO2, none of the ESMs used in the previous Intergovernmental Panel on Climate Change assessment accounted for P limitation. We diagnosed from ESM simulations the amount of P need to support increases in carbon uptake by natural ecosystems using two approaches: the demand derived from (1) changes in C stocks and (2) changes in NPP...
July 2017: Earth's Future
https://www.readbyqxmd.com/read/28983693/random-non-fasting-c-peptide-testing-can-identify-patients-with-insulin-treated-type-2-diabetes-at-high-risk-of-hypoglycaemia
#17
Suzy V Hope, Bridget A Knight, Beverley M Shields, Anita V Hill, Pratik Choudhary, W David Strain, Timothy J McDonald, Angus G Jones
AIMS/HYPOTHESIS: The aim of this study was to determine whether random non-fasting C-peptide (rCP) measurement can be used to assess hypoglycaemia risk in insulin-treated type 2 diabetes. METHODS: We compared continuous glucose monitoring-assessed SD of blood glucose and hypoglycaemia duration in 17 patients with insulin-treated type 2 diabetes and severe insulin deficiency (rCP < 200 pmol/l) and 17 matched insulin-treated control patients with type 2 diabetes but who had preserved endogenous insulin (rCP > 600 pmol/l)...
October 5, 2017: Diabetologia
https://www.readbyqxmd.com/read/28973826/projecting-the-future-of-an-alpine-ungulate-under-climate-change-scenarios
#18
Kevin S White, David P Gregovich, Taal Levi
Climate change represents a primary threat to species persistence and biodiversity at a global scale. Cold adapted alpine species are especially sensitive to climate change and can offer key "early warning signs" about deleterious effects of predicted change. Among mountain ungulates, survival, a key determinant of demographic performance, may be influenced by future climate in complex, and possibly opposing ways. Demographic data collected from 447 mountain goats in 10 coastal Alaska, USA, populations over a 37-year time span indicated that survival is highest during low snowfall winters and cool summers...
October 3, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28973396/incidental-prostate-cancer-in-patients-with-muscle-invasive-bladder-cancer-who-underwent-radical-cystoprostatectomy
#19
Toshikazu Tanaka, Takuya Koie, Chikara Ohyama, Yasuhiro Hashimoto, Atsushi Imai, Yuki Tobisawa, Shingo Hatakeyama, Hayato Yamamoto, Tohru Yoneyama, Hirotaka Horiguchi, Hirotake Kodama, Takahiro Yoneyama
Objectives: The aim of this study was to analyze the features of incidentally detected prostate cancer (PCa) in radical cystoprostatectomy (RCP) specimens to determine their pathological characteristics and clinical significance. Methods: In this retrospective study, we reviewed the clinical and pathological records of 431 consecutive patients with muscle-invasive bladder cancer who underwent RCP at Hirosaki University. Of these, we focused on 237 male patients with prostate-specific antigen (PSA) measurements and digital rectal examinations (DRE) that were recorded prior to the RCP...
November 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28970805/quadriceps-muscles-o2-extraction-and-emg-breakpoints-during-a-ramp-incremental-test
#20
Danilo Iannetta, Ahmad Qahtani, Guillaume Y Millet, Juan M Murias
Muscle deoxygenated breakpoint ([HHb]BP) has been found to be associated with other indices of exercise tolerance in the vastus lateralis (VL) muscle but not in the vastus medialis (VM) and rectus femoris (RF). Purpose: To investigate whether the [HHb]BP occurs also in the VM and RF muscles and whether or not it is associated with other physiological indices of exercise tolerance, such as the EMG threshold (EMGt) and the respiratory compensation point (RCP). Methods: Twelve young endurance trained participants performed maximal ramp incremental (RI) cycling tests (25-30 W·min(-1) increments)...
2017: Frontiers in Physiology
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