Read by QxMD icon Read


Zhengyuan Zhou, Satish K Chitneni, Nick Devoogdt, Michael R Zalutsky, Ganesan Vaidyanathan
In a previous study, we evaluated a HER2-specific single domain antibody fragment (sdAb) 2Rs15d labeled with18 F via conjugation of a residualizing prosthetic agent that was synthesized by copper-catalyzed azide-alkyne cycloaddition (CuAAC). In order to potentially increase overall efficiency and decrease the time required for labeling, we now investigate the use of a strain-promoted azide-alkyne cycloaddition (SPAAC) between the 2Rs15d sdAb, which had been pre-derivatized with an azide-containing residualizing moiety, and an18 F-labeled aza-dibenzocyclooctyne derivative...
March 10, 2018: Bioorganic & Medicinal Chemistry
Maik Rehnus, Kurt Bollmann, Dirk R Schmatz, Klaus Hackländer, Veronika Braunisch
Alpine and Arctic species are considered to be particularly vulnerable to climate change, which is expected to cause habitat loss, fragmentation and-ultimately-extinction of cold-adapted species. However, the impact of climate change on glacial relict populations is not well understood, and specific recommendations for adaptive conservation management are lacking. We focused on the mountain hare (Lepus timidus) as a model species and modelled species distribution in combination with patch and landscape-based connectivity metrics...
March 13, 2018: Global Change Biology
J Parente, M G Pereira, M Amraoui, E M Fischer
Heat waves (HW) can have devastating social, economic and environmental impacts. Together with long-term drought, they are the main factors contributing to wildfires. Surprisingly, the quantitative and objective analysis leading to the identification and characterization of HW in current and future climate conditions as well as its influence on the occurrence of extreme wildfires (EW) has never been performed for Portugal and are the main objectives of this study. For this reason, we assess HW in recent past and future climate based on a consistent high resolution meteorological database and have compared their occurrence with long and reliable, precise and detailed information about Portuguese fire events...
March 9, 2018: Science of the Total Environment
Didem Mumcuoglu, Laura de Miguel, Shehrazade Jekhmane, Claudia Siverino, Joachim Nickel, Thomas D Mueller, Johannes P van Leeuwen, Gerjo J van Osch, Sebastiaan G Kluijtmans
Bone morphogenetic protein-2 (BMP-2) is a powerful osteoinductive protein; however, there is a need for the development of a safe and efficient BMP-2 release system for bone regeneration therapies. Recombinant extracellular matrix proteins are promising next generation biomaterials since the proteins are well-defined, reproducible and can be tailored for specific applications. In this study, we have developed a novel and versatile BMP-2 delivery system using microspheres from a recombinant protein based on human collagen I (RCP)...
March 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Santanu Pakhira, Chandan Mazumdar, R Ranganathan, S Giri
In this work, we report the synthesis of a new ternary intermetallic compound, Nd2 Ni0.94 Si2.94 , that forms in single phase only in a defect crystal structure. The compound exhibits an antiferromagnetic transition below 7.2 K (TN ) followed by a spin cluster freezing behaviour below 2.85 K (Tf ), which makes the compound a reentrant spin cluster glass system. The detailed studies of dc and ac magnetization, heat capacity, non-equilibrium dynamical behaviour, viz., aging effect, temperature and field dependent magnetic relaxation and magnetic memory effect establish the compound to be a cluster-glass material below freezing temperature...
February 26, 2018: Physical Chemistry Chemical Physics: PCCP
David J Lieske, Vett K Lloyd
Ixodes scapularis, a known vector of Borrelia burgdorferi sensu stricto (Bbss), is undergoing range expansion in many parts of Canada. The province of New Brunswick, which borders jurisdictions with established populations of I. scapularis, constitutes a range expansion zone for this species. To better understand the current and potential future distribution of this tick under climate change projections, this study applied occupancy modelling to distributional records of adult ticks that successfully overwintered, obtained through passive surveillance...
February 16, 2018: Ticks and Tick-borne Diseases
Perrine Truong, Gregoire P Millet, Boris Gojanovic
This study aimed to investigate the differences in maximal oxygen uptake (V̇O2max ) and submaximal thresholds between a standard graded exercise test (GXT) and a perceptually regulated graded exercise test (PRGXT) in trained runners. Eleven well-trained middle- to long-distance runners performed both tests in a randomized order. PRGXT used incremental "clamps" of rating of perceived exertion (RPE) over 10×1-min stages on an automated treadmill equipped with a sonar sensor allowing them to change their running speed instantly and in a natural way...
February 23, 2018: International Journal of Sports Medicine
Julio Cesar Silva de Sousa, Camila Torriani-Pasin, Amanda Barboza Tosi, Rafael Yokoyama Fecchio, Luiz Augusto Riani da Costa, Cláudia Lúcia de Moraes Forjaz
OBJECTIVE: To evaluate whether virtual reality games (VRG) in stroke survivors produce significant and reproducible heart rate (HR) and oxygen consumption (VO2) responses during their execution, corresponding to an intensity between the anaerobic threshold (AT) and the respiratory compensation point (RCP). DESIGN: Single subjects repeated measure design SETTING: Stroke survivors registered from a rehabilitation program PARTICIPANTS: Twelve chronic hemiparetic stroke survivors (10 men, 58 ± 12 years) rated at 3 or 4 in the Functional Ambulation Categories (FAC)...
February 8, 2018: Archives of Physical Medicine and Rehabilitation
Natalia V Zhukovskaya, Elena I Bystrova, Joseph G Dubrovsky, Victor B Ivanov
Background and Aims: Information on cell cycle duration (T) in the root apical meristem (RAM) provides insight into root growth, development and evolution. We have previously proposed a simple method for evaluating T based on the dynamics of root growth (V), the number of cells in the RAM (Nm) and the length of fully elongated cells (l), which we named the rate-of-cell-production (RCP) method. Here, a global analysis was performed to confirm the reliability of this method in a range of angiosperm species and to assess the advantages of this approach...
February 7, 2018: Annals of Botany
Junior A Tremblay, Yan Boulanger, Dominic Cyr, Anthony R Taylor, David T Price, Martin-Hugues St-Laurent
Many studies project future bird ranges by relying on correlative species distribution models. Such models do not usually represent important processes explicitly related to climate change and harvesting, which limits their potential for predicting and understanding the future of boreal bird assemblages at the landscape scale. In this study, we attempted to assess the cumulative and specific impacts of both harvesting and climate-induced changes on wildfires and stand-level processes (e.g., reproduction, growth) in the boreal forest of eastern Canada...
2018: PloS One
Daria Vaulina, Morteza Nasirzadeh, Natalia Gomzina
This paper describes the novel approach for preparation of [18F]flumazenil ([18F]FMZ), well known radioligand for assessment of GABAA receptors by PET. The optimized reaction conditions allowed us to implement commercially available SPE cartridges for [18F]FMZ purification avoiding HPLC. All procedures were performed with TRACERlab FX N Pro synthesizer in 53 min. Developed approach provided [18F]FMZ with high RCP (> 97%) and low level of chemical impurities (< 5 µg/mL). FMZ was routinely synthesized in 6...
January 25, 2018: Applied Radiation and Isotopes
Julian Ramirez-Villegas, Alexandre Bryan Heinemann, Adriano Pereira de Castro, Flávio Breseghello, Carlos Navarro-Racines, Li Tao, Maria Camila Rebolledo, Andrew J Challinor
Rice is the most important food crop in the developing world. For rice production systems to address the challenges of increasing demand and climate change, potential and on-farm yield increases must be increased. Breeding is one of the main strategies toward such aim. Here, we hypothesise that climatic and atmospheric changes for the upland rice growing period in central Brazil are likely to alter environment groupings and drought stress patterns by 2050, leading to changing breeding targets during the 21st century...
January 25, 2018: Global Change Biology
B Guenet, M Camino-Serrano, P Ciais, M Tifafi, F Maignan, J L Soong, I A Janssens
Fresh carbon input (above and belowground) contributes to soil carbon sequestration, but also accelerates decomposition of soil organic matter through biological priming mechanisms. Currently, poor understanding precludes the incorporation of these priming mechanisms into the global carbon models used for future projections. Here, we show that priming can be incorporated based on a simple equation calibrated from incubation and verified against independent litter manipulation experiments in the global land surface model, ORCHIDEE...
January 24, 2018: Global Change Biology
Sang Gyu Lee, Sung Kyeom Kim, Hee Ju Lee, Hee Su Lee, Jin Hyoung Lee
Horticultural crop production and changes in physiological aspects during the growing season may be affected by climate change factors (CC), which include increased temperature and the associated doubling or tripling of atmospheric CO2 concentrations. However, the potential effects are complex and many parameters might impact on the observed effects. To evaluate the effects of CC, the growth, yield, fruit characteristics, photosynthetic traits, and morphological characteristics of hot peppers were investigated...
January 2018: Ecology and Evolution
Yun-Shan Yen, Daniel Chiung Jui Su, Kuo-Shu Yuan, Po-Wei Chen, Julie Chi Chow, Willy Chou
OBJECTIVES: The significance of the isocapnic buffering (IB) phase - the period between the first ventilatory threshold (1stVT) and respiratory compensation point (RCP) - has not been adequately established in patients. This study aimed to determine the clinical significance of the IB phase in coronary artery disease (CAD) patients. METHODS: This retrospective study included data of sixty-two CAD patients after coronary artery bypass graft (CABG) or percutaneous coronary intervention (PCI) performed in a single medical center between 2010-2014...
January 10, 2018: Physician and Sportsmedicine
Kevin Caen, Kobe Vermeire, Jan G Bourgois, Jan Boone
PURPOSE: The interchangeable use of whole-body exercise thresholds and breakpoints (BPs) in the local oxygenation response, as measured via near-infrared spectroscopy (NIRS), has recently been questioned in scientific literature. Therefore, the present study aimed to longitudinally investigate the interrelationship of four commonly used exercise thresholds: critical power (CP), the respiratory compensation point (RCP) and BPs in muscle (m[HHb]BP) and brain (c[O2Hb]BP) oxygenation. METHODS: Nine male participants (21...
January 8, 2018: Medicine and Science in Sports and Exercise
Päivi Jussila, Laura Krooks, Ritva Näpänkangas, Jari Päkkilä, Raija Lähdesmäki, Pertti Pirttiniemi, Aune Raustia
Objective To investigate the role of occlusion in temporomandibular disorders (TMDs) in the Northern Finland Birth Cohort 1966 (NFBC 1966). Methods Subjects (n = 1962) participated in clinical medical and dental examinations. The association between TMD signs and diagnoses with occlusal disturbances, i.e. malocclusions and occlusal interferences, was examined. Pearson's chi-square test, as expressed by odds ratios (OR) and 95% confidence intervals (CI) and logistic regression models, were used in the analysis...
January 8, 2018: Cranio: the Journal of Craniomandibular Practice
Ajay Ratna Bajracharya, Sagar Ratna Bajracharya, Arun Bhakta Shrestha, Sudan Bikash Maharjan
The Hindu Kush-Himalayan region is an important global freshwater resource. The hydrological regime of the region is vulnerable to climatic variations, especially precipitation and temperature. In our study, we modelled the impact of climate change on the water balance and hydrological regime of the snow dominated Kaligandaki Basin. The Soil and Water Assessment Tool (SWAT) was used for a future projection of changes in the hydrological regime of the Kaligandaki basin based on Representative Concentration Pathways Scenarios (RCP 4...
January 4, 2018: Science of the Total Environment
Boya Zhang, Guoxing Li, Yue Ma, Xiaochuan Pan
Human health faces unprecedented challenges caused by climate change. Thus, studies of the effect of temperature change on total mortality have been conducted in numerous countries. However, few of those studies focused on temperature-related mortality due to cardiovascular disease (CVD) or considered future population changes and adaptation to climate change. We present herein a projection of temperature-related mortality due to CVD under different climate change, population, and adaptation scenarios in Beijing, a megacity in China...
January 4, 2018: Environmental Research
Sameh Megdiche Borchani, Wissem Cheikh-Rouhou Koubaa, Makrem Megdiche
Structural, magnetic, magnetocaloric, electrical and magnetoresistance properties of an LaNaMnMoO6 powder sample have been investigated by X-ray diffraction (XRD), magnetic and electrical measurements. Our sample has been synthesized using the ceramic method. Rietveld refinements of the XRD patterns show that our sample is single phase and it crystallizes in the orthorhombic structure with Pnma space group. Magnetization versus temperature in a magnetic applied field of 0.05 T shows that our sample exhibits a paramagnetic-ferromagnetic transition with decreasing temperature...
November 2017: Royal Society Open Science
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"