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https://www.readbyqxmd.com/read/28213741/assembly-of-photoactive-orange-carotenoid-protein-from-its-domains-unravels-a-carotenoid-shuttle-mechanism
#1
Marcus Moldenhauer, Nikolai N Sluchanko, David Buhrke, Dmitry V Zlenko, Neslihan N Tavraz, Franz-Josef Schmitt, Peter Hildebrandt, Eugene G Maksimov, Thomas Friedrich
The photoswitchable orange carotenoid protein (OCP) is indispensable for cyanobacterial photoprotection by quenching phycobilisome fluorescence upon photoconversion from the orange OCP(O) to the red OCP(R) form. Cyanobacterial genomes frequently harbor, besides genes for orange carotenoid proteins (OCPs), several genes encoding homologs of OCP's N- or C-terminal domains (NTD, CTD). Unlike the well-studied NTD homologs, called Red Carotenoid Proteins (RCPs), the role of CTD homologs remains elusive. We show how OCP can be reassembled from its functional domains...
February 17, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28195457/effect-of-entrapped-solvent-on-the-evolution-of-lateral-order-in-self-assembled-p-s-r-mma-ps-b-pmma-systems-with-different-thicknesses
#2
Tommaso Jacopo Giammaria, Federico Ferrarese Lupi, Gabriele Seguini, Katia Sparnacci, Diego Antonioli, Valentina Gianotti, Michele Laus, Michele Perego
Block copolymers (BCPs) are emerging as a cost-effective nanofabrication tool to complement conventional optical lithography because they self-assemble in highly ordered polymeric templates with well-defined sub-20-nm periodic features. In this context, cylinder-forming polystyrene-block-poly(methyl methacrylate) BCPs are revealed as an interesting material of choice because the orientation of the nanostructures with respect to the underlying substrate can be effectively controlled by a poly(styrene-random-methyl methacrylate) random copolymer (RCP) brush layer grafted to the substrate prior to BCP deposition...
February 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28168033/invasive-termites-in-a-changing-climate-a-global-perspective
#3
Grzegorz Buczkowski, Cleo Bertelsmeier
Termites are ubiquitous insects in tropical, subtropical, and warm temperate regions and play an important role in ecosystems. Several termite species are also significant economic pests, mainly in urban areas where they attack human-made structures, but also in natural forest habitats. Worldwide, approximately 28 termite species are considered invasive and have spread beyond their native ranges, often with significant economic consequences. We used predictive climate modeling to provide the first global risk assessment for 13 of the world's most invasive termites...
February 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28166117/the-respiratory-compensation-point-is-not-a-valid-surrogate-for-critical-power
#4
Jeffrey A Leo, Surendran Sabapathy, Michael J Simmonds, Troy J Cross
PURPOSE: It is unclear whether the respiratory compensation point (RCP) may be used as a valid surrogate for critical power (CP). Accordingly, we sought to determine the measurement agreement between CP and the RCP obtained during incremental cycling of varying ramp slopes. METHODS: Eleven recreationally-active men completed three separate ramp-incremental cycling protocols, where the work rate increment was slow (SR: 15 W[BULLET OPERATOR]min), medium (MR: 30 W[BULLET OPERATOR]min) or fast (FR: 45 W[BULLET OPERATOR]min)...
February 4, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28148571/-every-breath-we-take-the-lifelong-impact-of-air-pollution-a-call-for-action
#5
Stephen T Holgate
Air pollution has become one of the major risks to human health because of the progressive increase in the use of vehicles powered by fossil fuels. While the risks of air pollution to health were thought to have been brought under control by the Clean Air Acts of the 1950s and 1960s, the situation of air pollution in the UK has now deteriorated to a point where it is contributing to 40,000 excess deaths each year. Here the findings of the RCP/RCPCH's 2015/16 Working Party on Air Pollution and Health are described and what actions now need to be taken...
February 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28143416/combination-therapy-with-rituximab-low-dose-cyclophosphamide-and-prednisone-for-idiopathic-membranous-nephropathy-a-case-series
#6
Frank B Cortazar, David E Leaf, Charles T Owens, Karen Laliberte, William F Pendergraft, John L Niles
BACKGROUND: Membranous nephropathy is a common cause of the nephrotic syndrome. Treatment with standard regimens fails to induce complete remission in most patients. We evaluated the efficacy of combination therapy with rituximab, low-dose, oral cyclophosphamide, and an accelerated prednisone taper (RCP) for the treatment of idiopathic membranous nephropathy. METHODS: We analyzed 15 consecutive patients with idiopathic membranous nephropathy treated with RCP at Massachusetts General Hospital...
February 1, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28142141/impact-of-prostate-involvement-on-outcomes-in-patients-treated-with-radical-cystoprostatectomy-for-bladder-cancer
#7
Marco Moschini, Shahrokh F Shariat, Massimo Freschi, Francesco Soria, Mohammad Abufaraj, Giorgio Gandaglia, Paolo Dell'Oglio, Agostino Mattei, Rocco Damiano, Andrea Salonia, Francesco Montorsi, Alberto Briganti, Andrea Gallina, Renzo Colombo
OBJECTIVE: The study aimed to evaluate the impact of the different types of prostate involvement at the time of radical cystoprostatectomy (RCP). METHODS: Data from 893 male patients treated with RCP at a referral center for bladder cancer (BCa) were assessed. Prostatic urothelial carcinoma (PUC) was stratified as stromal vs. urethral/duct involvements. Multivariable Cox regression analyses were built to test the impact of the presence of incidental prostate cancer (PCa) and PUC on survival outcomes...
February 1, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28138256/radiosynthesis-and-pharmacokinetics-of-18-f-fluoroethyl-bufalin-in-hepatocellular-carcinoma-bearing-mice
#8
Zhaoshuo Yang, Jianhua Liu, Qingqing Huang, Zhouji Zhang, Jiawei Zhang, Yanjia Pan, Yunke Yang, Dengfeng Cheng
PURPOSE: Bufalin, the main component of a Chinese traditional medicine chansu, shows convincing anticancer effects in a lot of tumor cell lines. However, its in vivo behavior is still unclear. This research aimed to evaluate how bufalin was dynamically absorbed after intravenous injection in animal models. We developed a radiosynthesis method of [(18)F]fluoroethyl bufalin to noninvasively evaluate the tissue biodistribution and pharmacokinetics in hepatocellular carcinoma-bearing mice...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28136035/preventing-falls-in-hospital
#9
Lynne Pearce
Essential facts Falls are the most frequently reported adverse events in hospitals, especially among older patients. According to the Royal College of Physicians (RCP) more than 240,000 falls are reported in acute hospitals and mental health trusts in England and Wale.
January 31, 2017: Nursing Older People
https://www.readbyqxmd.com/read/28128645/development-of-semiautomated-module-for-preparation-of-131-i-labeled-lipiodol-for-liver-cancer-therapy
#10
Archana Mukherjee, Suresh Subramanian, Rajwardhan Ambade, Bhaurao Avhad, Ashutosh Dash, Aruna Korde
Intra-arterial injection of (131)I Lipiodol is an effective treatment option for primary hepatocellular carcinoma as it delivers high radiation dose to liver tumor tissue with minimal accumulation in adjacent normal tissue. The present article demonstrates design, fabrication, and utilization of a semiautomated radiosynthesis module for preparation of (131)I labeled Lipiodol. The radiolabeling method was standardized for preparation of patient dose of (131)I labeled Lipiodol radiochemical yield (RCY); radiochemical purity (RCP) and pharmaceutical purity of the product were determined using optimized procedures...
February 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28116442/-occlusal-adjustment-treatment-of-pathological-migration-of-the-anterior-teeth-report-of-one-case
#11
Hui-Juan Cheng, Wei-Lei Hua, Kan Xu
This report presented a case of pathological movement of maxillary incisor. A 45-year-old female complained of increasing of the gap between the upper central incisors and increased mobility in the past two years. Clinical examination and Tscan Ⅲ showed the existence of deflective contacts between RCP and ICP. Fractionated treatment of adjustment of the deflective contacts led to relief of upper incisor mobility, and periapical films showed new bone formation.
October 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28113973/beyond-object-proposals-random-crop-pooling-for-multi-label-image-recognition
#12
Meng Wang, Changzhi Luo, Richang Hong, Jinhui Tang, Jiashi Feng
Learning high-level image representations using object proposals has achieved remarkable success in multilabel image recognition. However, most object proposals provide merely coarse information about the objects, and only carefully selected proposals can be helpful for boosting the performance of multi-label image recognition. In this work, we propose an object-proposal-free framework for multi-label image recognition: random crop pooling (RCP). Basically, RCP performs stochastic scaling and cropping over images before feeding them to a standard convolutional neural network, which works quite well with a max-pooling operation for recognizing the complex contents of multi-label images...
September 22, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28095942/association-of-neighbourhood-food-availability-with-the-consumption-of-processed-and-ultra-processed-food-products-by-children-in-a-city-of-brazil-a-multilevel-analysis
#13
Fernanda Helena Marrocos Leite, Elena de Carvalho Cremm, Débora Silva Costa de Abreu, Maria Aparecida de Oliveira, Nadine Budd, Paula Andrea Martins
OBJECTIVE: To investigate the association between neighbourhood food availability and the consumption of ready-to-consume products (RCP), either processed or ultra-processed, and unprocessed/minimally processed foods (UF-MPF) by children. DESIGN: Cross-sectional. 24 h Dietary recalls were collected from children from January 2010 to June 2011. Neighbourhood food availability data were collected from 672 food stores located within 500 m of participants' homes, using an adapted and validated instrument...
January 18, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28094785/high-resolution-african-population-projections-from-radiative-forcing-and-socio-economic-models-2000-to-2100
#14
Niklas Boke-Olén, Abdulhakim M Abdi, Ola Hall, Veiko Lehsten
For its fifth assessment report, the Intergovernmental Panel on Climate Change divided future scenario projections (2005-2100) into two groups: Socio-Economic Pathways (SSPs) and Representative Concentration Pathways (RCPs). Each SSP has country-level urban and rural population projections, while the RCPs are based on radiative forcing caused by greenhouse gases, aerosols and associated land-use change. In order for these projections to be applicable in earth system models, SSP and RCP population projections must be at the same spatial scale...
January 17, 2017: Scientific Data
https://www.readbyqxmd.com/read/28094627/preventing-falls-in-hospital
#15
Lynne Pearce
Falls are the most frequent adverse event reported in hospitals, usually affecting older patients. Every year, more than 240,000 falls are reported in acute hospitals and mental health trusts in England and Wales, equivalent to more than 600 per day, according to the Royal College of Physicians (RCP).
January 4, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28063186/the-combined-and-separate-impacts-of-climate-extremes-on-the-current-and-future-us-rainfed-maize-and-soybean-production-under-elevated-co2
#16
Zhenong Jin, Qianlai Zhuang, Jiali Wang, Sotirios V Archontoulis, Zachary Zobel, Veerabhadra R Kotamarthi
Heat and drought are two emerging climatic threats to the US maize and soybean production, yet their impacts on yields are collectively determined by the magnitude of climate change and rising atmospheric CO2 concentrations. This study quantifies the combined and separate impacts of high temperature, heat and drought stresses on the current and future US rainfed maize and soybean production, and for the first time characterizes spatial shifts in the relative importance of individual stress. Crop yields are simulated using the Agricultural Production Systems sIMulator (APSIM), driven by high-resolution (12 km) dynamically downscaled climate projections for 1995-2004 and 2085-2094...
January 7, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28055084/forward-head-posture-and-activation-of-rectus-capitis-posterior-muscles
#17
Richard C Hallgren, Steven J Pierce, Dhruv B Sharma, Jacob J Rowan
CONTEXT: Rectus capitis posterior (RCP) muscles have physical attachments to the pain-sensitive spinal dura. Atrophy of these muscles is associated with chronic headache in some patients. The authors suspect that the significance of atrophy in the RCP muscles has been undervalued because the functional role of these muscles is not well defined. OBJECTIVE: To determine whether a statistically significant change in normalized levels of electromyographic activity in RCP muscles occurs when the head is voluntarily moved from a self-selected neutral head position to a protruded head position...
January 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28013122/development-of-11-c-3-h-thk-5351-a-potential-novel-carbon-11-tau-imaging-pet-radioligand
#18
Vladimir Stepanov, Marie Svedberg, Zhisheng Jia, Raisa Krasikova, Laetitia Lemoine, Nobujuki Okamura, Shozo Furumoto, Nicholas Mitsios, Jan Mulder, Bengt Långström, Agneta Nordberg, Christer Halldin
INTRODUCTION: Due to the rise in the number of patients with dementia the imperative for finding new diagnostic and treatment options becomes ever more pressing. While significant progress has been made in PET imaging of Aβ aggregates both in vitro and in vivo, options for imaging tau protein aggregates selectively are still limited. Based on the work previously published by researchers from the Tohoku University, Japan, that resulted in the development of [(18)F]THK-5351, we have undertaken an effort to develop a carbon-11 version of the identical structure - [(11)C]THK-5351...
December 9, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27992934/novel-99mtc-radiolabeled-anionic-linear-globular-peg-based-dendrimer-chlorambucil-non-invasive-method-for-in-vivo-biodistribution
#19
S M Ghoreishi, A Khalaj, A B-Rajabi, A D Azar, M S Ardestani, A Assadi
Chlorambucil (CBL) is an alkylating agent, which widely use in the treatment of various types of tumors. The main purpose of this study is to evaluate the in-vivo biodistribution of CBL conjugated to the anionic dendrimer, which has a great ability to labeled with (99m)Tc through binding to carboxylate terminate groups. Whole body scans were used to analyze the percentage of the injected dose in different times. Radiochemical purity (RCP) and in-vivo biodistribution were also calculated with the SPECT/CT instrument...
December 19, 2016: Drug Research
https://www.readbyqxmd.com/read/27982187/effect-of-acid-etching-silane-and-thermal-cycling-on-the-bond-strength-of-metallic-brackets-to-ceramic
#20
Natália Regina Santos de Matos, Ana Rosa Costa, Heloísa Cristina Valdrighi, Américo Bortolazzo Correr, Silvia Amélia Vedovello, Milton Santamaria, Lourenço Correr-Sobrinho
The aim of this study was to evaluate the effect of silanes, thermal cycling and acid etching on the shear bond strength (SBS) of metallic brackets to feldspathic ceramic. Feldspathic ceramic cylinders (Groups 1, 2, 5 and 6) were etched for 60 s with 10% hydrofluoric acid and Groups 3, 4, 7 and 8, without acid etching. Two layers of silane Clearfil Ceramic Primer (CCP, Groups 1 to 4) and two layers of RelyX Ceramic Primer (RCP, groups 5 to 8) were applied and dried for 60 s. Brackets were bonded to the cylinders with Transbond XT and light-activated for 40 s with Bluephase G2...
October 2016: Brazilian Dental Journal
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