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https://www.readbyqxmd.com/read/28321366/climate-change-induced-range-shifts-of-three-allergenic-ragweeds-ambrosia-l-in-europe-and-their-potential-impact-on-human-health
#1
Karen Rasmussen, Jakob Thyrring, Robert Muscarella, Finn Borchsenius
Invasive allergenic plant species may have severe health-related impacts. In this study we aim to predict the effects of climate change on the distribution of three allergenic ragweed species (Ambrosia spp.) in Europe and discuss the potential associated health impact. We built species distribution models based on presence-only data for three ragweed species, using MAXENT software. Future climatic habitat suitability was modeled under two IPCC climate change scenarios (RCP 6.0 and RCP 8.5). We quantify the extent of the increase in 'high allergy risk' (HAR) areas, i...
2017: PeerJ
https://www.readbyqxmd.com/read/28319711/why-coastal-upwelling-is-expected-to-increase-along-the-western-iberian-peninsula-over-the-next-century
#2
Magda Catarina Sousa, Maite deCastro, Ines Alvarez, Moncho Gomez-Gesteira, João Miguel Dias
Former studies about coastal upwelling along the Western Iberian Peninsula (WIP) using historical data indicated contradictory results, showing either its strengthening or reduction, while previous studies using Global Climate Models (GCMs) indicated that global warming is likely to intensify this phenomenon although predicting different rates and not justifying the patterns found. Taking advantage of the recent high spatial resolution Regional Climate Models (RCMs) projections from EURO-CORDEX project (Representative Concentration Pathway, RCP 8...
March 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28314255/anti-metastatic-efficacy-of-traditional-chinese-medicine-tcm-ginsenoside-conjugated-to-a-vefgr-3-antibody-on-human-gastric-cancer-in-an-orthotopic-mouse-model
#3
Xiaojun Dai, Dongmei Liu, Moxiang Liu, Xiaochun Zhang, Weiming Wang, Feng Jin, Yayun Qian, Xuanyi Wang, Jingjing Zhao, Yongjian Wu, Fangfang Xiong, N A Chang, Y U Sun, Zhijian Yang, Robert M Hoffman, Yanqing Liu
Background/Aim: The aim of the present study was to investigate the efficacy of a traditional Chinese medicine (TCM), VEGFR-3 antibody-conjugated ginsenoside Rg3nanoemulsion (VRIN), targeting lymphangiogenesis, on the inhibition of tumor growth and metastasis in an orthotopic mouse model of human gastric cancer. Materials and Methods: An orthotopic nude-mouse model of gastric cancer was established with the red fluorescent protein (RFP)-expressing human gastric cancer cell line NUGC-4-RFP. The tumor-bearing mice were treated with vehicle (0...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28302640/rcp-survey-highlights-workload-morale-and-patient-safety-concerns
#4
Abi Rimmer
No abstract text is available yet for this article.
March 16, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28294115/phosphorylation-of-rab-coupling-protein-by-lmtk3-controls-rab14-dependent-epha2-trafficking-to-promote-cell-cell-repulsion
#5
Christine Gundry, Sergi Marco, Elena Rainero, Bryan Miller, Emmanuel Dornier, Louise Mitchell, Patrick T Caswell, Andrew D Campbell, Anna Hogeweg, Owen J Sansom, Jennifer P Morton, Jim C Norman
The Rab GTPase effector, Rab-coupling protein (RCP) is known to promote invasive behaviour in vitro by controlling integrin and receptor tyrosine kinase (RTK) trafficking, but how RCP influences metastasis in vivo is unclear. Here we identify an RTK of the Eph family, EphA2, to be a cargo of an RCP-regulated endocytic pathway which controls cell:cell repulsion and metastasis in vivo. Phosphorylation of RCP at Ser(435) by Lemur tyrosine kinase-3 (LMTK3) and of EphA2 at Ser(897) by Akt are both necessary to promote Rab14-dependent (and Rab11-independent) trafficking of EphA2 which generates cell:cell repulsion events that drive tumour cells apart...
March 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28277204/towards-integrating-primary-care-with-cancer-care-a-regional-study-of-current-gaps-and-opportunities-in-canada
#6
Jonathan Sussman, Daryl Bainbridge, William K Evans
BACKGROUND AND OBJECTIVES: Better integration between cancer care systems and primary care physicians (PCPs) is a goal of most healthcare systems, but little direction exists on how this can be achieved. This study systematically examined the extent of integration between PCPs and a regional cancer program (RCP) to identify opportunities for improvement. METHOD: Cross-sectional survey of all practising PCPs in the region of interest using a study-specific instrument based on a three-tier conceptualization of integration...
February 2017: Healthcare Policy, Politiques de Santé
https://www.readbyqxmd.com/read/28258810/apically-extruded-debris-after-retreatment-procedure-with-reciproc-protaper-next-and-twisted-file-adaptive-instruments
#7
Koray Yılmaz, Taha Özyürek
INTRODUCTION: The aim of this study was to compare the amount of debris extruded from the apex during retreatment procedures with ProTaper Next (PTN; Dentsply Maillefer, Ballaigues, Switzerland), Reciproc (RCP; VDW, Munich, Germany), and Twisted File Adaptive (TFA; SybronEndo, Orange, CA) files and the duration of these retreatment procedures. METHODS: Ninety upper central incisor teeth were prepared and filled with gutta-percha and AH Plus sealer (Dentsply DeTrey, Konstanz, Germany) using the vertical compaction technique...
February 28, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28254143/the-near-infrared-spectroscopy-derived-deoxygenated-haemoglobin-breaking-point-is-a-repeatable-measure-that-demarcates-exercise-intensity-domains
#8
Danilo Iannetta, Ahmad Qahtani, Felipe Mattioni Maturana, Juan Manuel Murias
OBJECTIVES: A breaking-point in the near-infrared spectroscopy (NIRS)-derived deoxygenated haemoglobin ([HHb]) profile towards the end of a ramp incremental (RI) cycling test has been associated to the respiratory compensation point (RCP). Despite the physiological value of this measure, its repeatability remains unknown. The aim was to examine the repeatability of the [HHb] breaking-point ([HHb]BP) and its association to RCP during a RI cycling test. DESIGN: A repeated measures design was performed on 11 males (30...
February 18, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28247927/osteogenesis-and-mineralization-of-mesenchymal-stem-cells-in-collagen-type-i-based-recombinant-peptide-scaffolds
#9
Kendell M Pawelec, Davide Confalonieri, Franziska Ehlicke, Huibert A van Boxtel, Heike Walles, Sebastiaan G J M Kluijtmans
Recombinant peptides have the power to harness the inherent biocompatibility of natural macro-molecules, while maintaining a defined chemistry for use in tissue engineering. Creating scaffolds from peptides requires stabilization via cross-linking, a process known to alter both mechanics and density of adhesion ligands. The chemistry and mechanics of linear scaffolds from a recombinant peptide based on human collagen type I (RCP) was investigated after cross-linking. Three treatments were compared: dehydrothermal treatment (DHT), hexamethylene diisocyanate (HMDIC), and genipin...
March 1, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28240077/preventing-falls-in-hospital
#10
Lynne Pearce
Essential facts Falls are the most frequent adverse event reported in hospitals, usually affecting older patients. Every year, more than 240,000 falls are reported in acute hospitals and mental health trusts in England and Wales, equivalent to more than 600 a day, according to the Royal College of Physicians (RCP). But research shows that when nurses, doctors and therapists work together, falls can be reduced by 20-30%.
February 27, 2017: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/28213741/assembly-of-photoactive-orange-carotenoid-protein-from-its-domains-unravels-a-carotenoid-shuttle-mechanism
#11
Marcus Moldenhauer, Nikolai N Sluchanko, David Buhrke, Dmitry V Zlenko, Neslihan N Tavraz, Franz-Josef Schmitt, Peter Hildebrandt, Eugene G Maksimov, Thomas Friedrich
The photoswitchable orange carotenoid protein (OCP) is indispensable for cyanobacterial photoprotection by quenching phycobilisome fluorescence upon photoconversion from the orange OCP(O) to the red OCP(R) form. Cyanobacterial genomes frequently harbor, besides genes for orange carotenoid proteins (OCPs), several genes encoding homologs of OCP's N- or C-terminal domains (NTD, CTD). Unlike the well-studied NTD homologs, called Red Carotenoid Proteins (RCPs), the role of CTD homologs remains elusive. We show how OCP can be reassembled from its functional domains...
February 17, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28195457/effect-of-entrapped-solvent-on-the-evolution-of-lateral-order-in-self-assembled-p-s-r-mma-ps-b-pmma-systems-with-different-thicknesses
#12
Tommaso Jacopo Giammaria, Federico Ferrarese Lupi, Gabriele Seguini, Katia Sparnacci, Diego Antonioli, Valentina Gianotti, Michele Laus, Michele Perego
Block copolymers (BCPs) are emerging as a cost-effective nanofabrication tool to complement conventional optical lithography because they self-assemble in highly ordered polymeric templates with well-defined sub-20-nm periodic features. In this context, cylinder-forming polystyrene-block-poly(methyl methacrylate) BCPs are revealed as an interesting material of choice because the orientation of the nanostructures with respect to the underlying substrate can be effectively controlled by a poly(styrene-random-methyl methacrylate) random copolymer (RCP) brush layer grafted to the substrate prior to BCP deposition...
February 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28168033/invasive-termites-in-a-changing-climate-a-global-perspective
#13
Grzegorz Buczkowski, Cleo Bertelsmeier
Termites are ubiquitous insects in tropical, subtropical, and warm temperate regions and play an important role in ecosystems. Several termite species are also significant economic pests, mainly in urban areas where they attack human-made structures, but also in natural forest habitats. Worldwide, approximately 28 termite species are considered invasive and have spread beyond their native ranges, often with significant economic consequences. We used predictive climate modeling to provide the first global risk assessment for 13 of the world's most invasive termites...
February 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28166117/the-respiratory-compensation-point-is-not-a-valid-surrogate-for-critical-power
#14
Jeffrey A Leo, Surendran Sabapathy, Michael J Simmonds, Troy J Cross
PURPOSE: It is unclear whether the respiratory compensation point (RCP) may be used as a valid surrogate for critical power (CP). Accordingly, we sought to determine the measurement agreement between CP and the RCP obtained during incremental cycling of varying ramp slopes. METHODS: Eleven recreationally-active men completed three separate ramp-incremental cycling protocols, where the work rate increment was slow (SR: 15 W[BULLET OPERATOR]min), medium (MR: 30 W[BULLET OPERATOR]min) or fast (FR: 45 W[BULLET OPERATOR]min)...
February 4, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28148571/-every-breath-we-take-the-lifelong-impact-of-air-pollution-a-call-for-action
#15
Stephen T Holgate
Air pollution has become one of the major risks to human health because of the progressive increase in the use of vehicles powered by fossil fuels. While the risks of air pollution to health were thought to have been brought under control by the Clean Air Acts of the 1950s and 1960s, the situation of air pollution in the UK has now deteriorated to a point where it is contributing to 40,000 excess deaths each year. Here the findings of the RCP/RCPCH's 2015/16 Working Party on Air Pollution and Health are described and what actions now need to be taken...
February 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28143416/combination-therapy-with-rituximab-low-dose-cyclophosphamide-and-prednisone-for-idiopathic-membranous-nephropathy-a-case-series
#16
Frank B Cortazar, David E Leaf, Charles T Owens, Karen Laliberte, William F Pendergraft, John L Niles
BACKGROUND: Membranous nephropathy is a common cause of the nephrotic syndrome. Treatment with standard regimens fails to induce complete remission in most patients. We evaluated the efficacy of combination therapy with rituximab, low-dose, oral cyclophosphamide, and an accelerated prednisone taper (RCP) for the treatment of idiopathic membranous nephropathy. METHODS: We analyzed 15 consecutive patients with idiopathic membranous nephropathy treated with RCP at Massachusetts General Hospital...
February 1, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28142141/impact-of-prostate-involvement-on-outcomes-in-patients-treated-with-radical-cystoprostatectomy-for-bladder-cancer
#17
Marco Moschini, Shahrokh F Shariat, Massimo Freschi, Francesco Soria, Mohammad Abufaraj, Giorgio Gandaglia, Paolo Dell'Oglio, Agostino Mattei, Rocco Damiano, Andrea Salonia, Francesco Montorsi, Alberto Briganti, Andrea Gallina, Renzo Colombo
OBJECTIVE: The study aimed to evaluate the impact of the different types of prostate involvement at the time of radical cystoprostatectomy (RCP). METHODS: Data from 893 male patients treated with RCP at a referral center for bladder cancer (BCa) were assessed. Prostatic urothelial carcinoma (PUC) was stratified as stromal vs. urethral/duct involvements. Multivariable Cox regression analyses were built to test the impact of the presence of incidental prostate cancer (PCa) and PUC on survival outcomes...
February 1, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28138256/radiosynthesis-and-pharmacokinetics-of-18-f-fluoroethyl-bufalin-in-hepatocellular-carcinoma-bearing-mice
#18
Zhaoshuo Yang, Jianhua Liu, Qingqing Huang, Zhouji Zhang, Jiawei Zhang, Yanjia Pan, Yunke Yang, Dengfeng Cheng
PURPOSE: Bufalin, the main component of a Chinese traditional medicine chansu, shows convincing anticancer effects in a lot of tumor cell lines. However, its in vivo behavior is still unclear. This research aimed to evaluate how bufalin was dynamically absorbed after intravenous injection in animal models. We developed a radiosynthesis method of [(18)F]fluoroethyl bufalin to noninvasively evaluate the tissue biodistribution and pharmacokinetics in hepatocellular carcinoma-bearing mice...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28136035/preventing-falls-in-hospital
#19
Lynne Pearce
Essential facts Falls are the most frequently reported adverse events in hospitals, especially among older patients. According to the Royal College of Physicians (RCP) more than 240,000 falls are reported in acute hospitals and mental health trusts in England and Wale.
January 31, 2017: Nursing Older People
https://www.readbyqxmd.com/read/28128645/development-of-semiautomated-module-for-preparation-of-131-i-labeled-lipiodol-for-liver-cancer-therapy
#20
Archana Mukherjee, Suresh Subramanian, Rajwardhan Ambade, Bhaurao Avhad, Ashutosh Dash, Aruna Korde
Intra-arterial injection of (131)I Lipiodol is an effective treatment option for primary hepatocellular carcinoma as it delivers high radiation dose to liver tumor tissue with minimal accumulation in adjacent normal tissue. The present article demonstrates design, fabrication, and utilization of a semiautomated radiosynthesis module for preparation of (131)I labeled Lipiodol. The radiolabeling method was standardized for preparation of patient dose of (131)I labeled Lipiodol radiochemical yield (RCY); radiochemical purity (RCP) and pharmaceutical purity of the product were determined using optimized procedures...
February 2017: Cancer Biotherapy & Radiopharmaceuticals
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