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Teunis Jansen, Søren Post, Trond Kristiansen, Guðmundur J Óskarsson, Jesper Boje, Brian R MacKenzie, Mala Broberg, Helle Siegstad
Geographic redistribution of living natural resources changes access and thereby harvesting opportunities between countries. Internationally shared fish resources can be sensitive to shifts in the marine environment and this may have great impact on the economies of countries and regions that rely most heavily on fisheries to provide employment and food supply. Here we present a climate change-related biotic expansion of a rich natural resource with substantial economic consequences, namely the appearance of northeast Atlantic mackerel (Scomber scombrus) in Greenlandic waters...
October 2016: Ecological Applications: a Publication of the Ecological Society of America
Min Liu, Wei Fang, Shuang Liu
In this study, we evaluated seven new 99mTc(III) complexes [99mTcCl(CDO)(CDOH)2B-R] (99mTc-2Fboroxime: R = 2-formylfuran-3-yl (2F); 99mTc-3Fboroxime: R = furan-3-yl (3F); 99mTc-5Fboroxime: R = 5-formyfuran-2-yl (5F); 99mTc-HPboroxime: R = 6-hydroxylpyridin-2-yl (HP); 99mTc-MPYboroxime: R = 5-methoxypyridin-3-yl (MPY); 99mTc-PMboroxime: R = 1,5-pyrimidin-3-yl (PM), and 99mTc-4PYboroxime: R = pyridin-4-yl (4PY)) for their potential as heart imaging agents. All new 99mTc(III) radiotracers except 99mTc-2Fboroxime were prepared with high radiochemical purity (RCP > 95%)...
October 13, 2016: Bioconjugate Chemistry
Edouard-Jules Laforgue, Samuel Bulteau, Jennyfer Cholet, Caroline Victorri-Vigneau, Marie Guitteny, Nicolas Mauduit, Jean-Marie Vanelle, Anne Sauvaget
PURPOSE: There are differences between recommendations and practice in the pharmacological treatment of acute mania. OBJECTIVE: The objective was to assess conformity of the anti-manic prescription between national recommendations (Haute Autorité de santé [French health authority, HAS] and "résumé des caractéristiques du produit" [product characteristics, RCP]) and clinical practice. METHODS: We observed the drug prescriptions of in-patients for a manic episode...
September 15, 2016: Thérapie
V Chaudhary, R V Ramanujan
Low cost, earth abundant, rare earth free magnetocaloric nanoparticles have attracted an enormous amount of attention for green, energy efficient, active near room temperature thermal management. Hence, we investigated the magnetocaloric properties of transition metal based (Fe70Ni30)100-xCrx (x = 1, 3, 5, 6 and 7) nanoparticles. The influence of Cr additions on the Curie temperature (TC) was studied. Only 5% of Cr can reduce the TC from ~438 K to 258 K. These alloys exhibit broad entropy v/s temperature curves, which is useful to enhance relative cooling power (RCP)...
October 11, 2016: Scientific Reports
Kristof Vandekerckhove, Ilse Coomans, Annelies Moerman, Daniel De Wolf, Jan Boone
AIMS: To characterize the oxygenation responses at cerebral and locomotor muscle level to incremental exercise in children and to assess the interrelationship with the pulmonary gas exchange responses. METHODS: Eighteen children (9 boys, 9 girls) (mean age 10.9 ± 1.0 years) performed incremental cycle ramp exercise to exhaustion. The concentration of cerebral and muscle oxygenated (O2Hb) and deoxygenated (HHb) hemoglobin (by means of near-infrared spectroscopy) and pulmonary gas exchange was recorded...
October 6, 2016: European Journal of Applied Physiology
Marwène Oumezzine, Aurelian Catalin Galca, Iuliana Pasuk, Cristina Florentina Chirila, Aurel Leca, Victor Kuncser, Liviu Cristian Tanase, Andrei Kuncser, Corneliu Ghica, Mohamed Oumezzine
Epitaxial La0.67Ba0.33Ti0.02Mn0.98O3 (denoted as LBTMO hereafter) thin films of approximately 95 nm thickness were deposited by a pulsed laser deposition technique onto SrTiO3 (STO) (001) substrates. High-resolution X-ray diffraction (HRXRD) and transmission electron microscopy (TEM) investigations revealed that the films are epilayers with a four-fold symmetry around the [001] direction. Cross-sectional TEM and the presence of Pendellosung fringes in the XRD profiles demonstrate smooth interfaces. The STO substrate induces an in-plane compressive strain, which leads to a slight tetragonality of the film structure...
September 27, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Robert Anton Cesnjevar, Ariawan Purbojo, Frank Muench, Joerg Juengert, André Rueffer
Reduction of mortality and morbidity in congenital cardiac surgery has always been and remains a major target for the complete team involved. As operative techniques are more and more standardized and refined, surgical risk and associated complication rates have constantly been reduced to an acceptable level but are both still present. Aortic arch surgery in neonates seems to be of particular interest, because perfusion techniques differ widely among institutions and an ideal form of a so called "total body perfusion (TBP)" is somewhat difficult to achieve...
July 2016: Translational pediatrics
Michael Azad
The Royal College of Physicians (RCP) organised an inaugural 1-day conference, the aim of which was to look into some of the key issues that junior doctors need to address when beginning their careers. The target audience was medical students but a few foundation doctors were also in attendance. The conference also helped to increase RCP engagement with medical students and foundation doctors. The day was co-chaired by Professor Kate Thomas (vice dean, University of Birmingham) and Dr Andrew Macleod and Dr Kanwaljit Sandhu (RCP regional advisors for the West Midlands)...
October 2016: Clinical Medicine: Journal of the Royal College of Physicians of London
Joshua B Kaelberer, Michael A O'Donnell, Darrion L Mitchell, Anthony N Snow, Sarah L Mott, John M Buatti, Mark C Smith, John M Watkins
BACKGROUND: The current standard of care for men with muscle-invasive bladder cancer is radical cystoprostatectomy (RCP). One-third of RCP specimens demonstrate incidental prostate cancer, primarily reported in small series with limited follow-up. The aim of this study is to report mature outcomes, including patterns of failure and disease-specific recurrence rates, and survival, for a large cohort of men with incidental prostate cancer at RCP performed at a tertiary referral center. METHODS: This retrospective study describes cancer control and survival rates for men who underwent RCP for bladder cancer and were found incidentally to have prostate cancer...
September 2016: Prostate International
Min Liu, Yumin Zheng, Ugur Avcibasi, Shuang Liu
INTRODUCTION: In this study, novel (99m)Tc(III)-azide complexes [(99m)Tc(N3)(CDO)(CDOH)2B-R] ((99m)Tc-ISboroxime-N3: R=IS; (99m)Tc-MPboroxime-N3: R=MP; (99m)Tc-PAboroxime-N3: R=PA; (99m)Tc-PYboroxime-N3: R=PY; and (99m)Tc-Uboroxime-N3: R=5U) were evaluated as heart imaging agents. METHODS: Complexes [(99m)Tc(N3)(CDO)(CDOH)2B-R] (R=IS, MP, PA, PY and 5U) were prepared by ligand exchange between NaN3 and [(99m)TcCl(CDO)(CDOH)2B-R]. Biodistribution and imaging studies were carried out in Sprague-Dawley rats...
May 9, 2016: Nuclear Medicine and Biology
Tarik Ghadban, Matthias Reeh, Alexandra M Koenig, Michael F Nentwich, Eugen Bellon, Jakob R Izbicki, Yogesh K Vashist, Asad Kutup
OBJECTIVE: The aim of this study is to investigate the impact of the circumferential resection margin (CRM) in esophageal cancer on survival and recurrence in patients without pretreatment. BACKGROUND: Whereas the infiltration of the proximal or distal resection margin is associated with poor survival and higher recurrence, studies looking at the role of the circumferential resection margin on survival and local recurrence after esophagectomy are conflicting. METHODS: Influence of CRM infiltration according to the College of American Pathologists (CAP) and Royal College of Pathologists (RCP) on long-term survival of 180 patients with resected pT3 tumors and without neoadjuvant therapy was analyzed...
September 9, 2016: Annals of Surgery
Václav Šlouf, Valentyna Kuznetsova, Marcel Fuciman, Céline Bourcier de Carbon, Adjélé Wilson, Diana Kirilovsky, Tomáš Polívka
A quenching mechanism mediated by the orange carotenoid protein (OCP) is one of the ways cyanobacteria protect themselves against photooxidative stress. Here, we present a femtosecond spectroscopic study comparing OCP and RCP (red carotenoid protein) samples binding different carotenoids. We confirmed significant changes in carotenoid configuration upon OCP activation reported by Leverenz et al. (Science 348:1463-1466. doi: 10.1126/science.aaa7234 , 2015) by comparing the transient spectra of OCP and RCP. The most important marker of these changes was the magnitude of the transient signal associated with the carotenoid intramolecular charge-transfer (ICT) state...
September 9, 2016: Photosynthesis Research
Jittima Saengsuwan, Lucia Berger, Corina Schuster-Amft, Tobias Nef, Kenneth J Hunt
BACKGROUND: Exercise testing devices for evaluating cardiopulmonary fitness in patients with severe disability after stroke are lacking, but we have adapted a robotics-assisted tilt table (RATT) for cardiopulmonary exercise testing (CPET). Using the RATT in a sample of patients after stroke, this study aimed to investigate test-retest reliability and repeatability of CPET and to prospectively investigate changes in cardiopulmonary outcomes over a period of four weeks. METHODS: Stroke patients with all degrees of disability underwent 3 separate CPET sessions: 2 tests at baseline (TB1 and TB2) and 1 test at follow up (TF)...
2016: BMC Neurology
Vívian T Martins, Mariana C Duarte, Daniela P Lage, Lourena E Costa, Ana Maria R S Carvalho, Tiago A O Mendes, Bruno M Roatt, Daniel Menezes-Souza, Manuel Soto, Eduardo A F Coelho
In the present study, a recombinant chimeric protein (RCP), which was composed by specific CD4(+) and CD8(+) T cell epitopes to murine and human haplotypes, was evaluated as an immunogen against Leishmania infantum infection in a murine model. BALB/c mice received saline, were immunized with saponin or with RCP with or without an adjuvant. The results showed that RCP/saponin-vaccinated mice presented significantly higher levels of antileishmanial IFN-γ, IL-12 and GM-CSF before and after challenge, which were associated with the reduction of IL-4 and IL-10 mediated responses...
September 4, 2016: Parasite Immunology
Solomon Kibret, Jonathan Lautze, Matthew McCartney, Luxon Nhamo, G Glenn Wilson
BACKGROUND: Sub-Saharan Africa (SSA) has embarked on a new era of dam building to improve food security and promote economic development. Nonetheless, the future impacts of dams on malaria transmission are poorly understood and seldom investigated in the context of climate and demographic change. METHODS: The distribution of malaria in the vicinity of 1268 existing dams in SSA was mapped under the Intergovernmental Panel on Climate Change (IPCC) representative concentration pathways (RCP) 2...
2016: Malaria Journal
David B Meyer, Jeffrey P Jacobs, Kevin Hill, Amelia S Wallace, Brian Bateson, Marshall L Jacobs
BACKGROUND: Regional cerebral perfusion (RCP) is used as an adjunct or alternative to deep hypothermic circulatory arrest (DHCA) for neonates and infants undergoing aortic arch repair. Clinical studies have not demonstrated clear superiority of either strategy, and multicenter data regarding current use of these strategies are lacking. We sought to describe the variability in contemporary practice patterns for use of these techniques. METHODS: The Society of Thoracic Surgeons Congenital Heart Surgery Database (2010-2013) was queried to identify neonates and infants whose index operation involved aortic arch repair with cardiopulmonary bypass...
September 2016: World Journal for Pediatric & Congenital Heart Surgery
Omar Fahmy, Mohd Ghani Khairul-Asri, Tina Schubert, Markus Renninger, Arnulf Stenzl, Georgios Gakis
PURPOSE: There is controversy in literature about the oncological significance of incidental prostate cancer (IPC) detected at radical cystoprostatectomy (RCP) for bladder cancer (BC). MATERIALS AND METHODS: Online search was conducted for studies reporting on IPC in cystoprostatectomy specimens. After following the PRISMA guidelines, a total of 34 reports containing 13140 patients who underwent RCP for BC with no previous history of prostate cancer were identified...
August 25, 2016: Journal of Urology
Sotiris C Stamou, Laura A Rausch, Nicholas T Kouchoukos, Kevin W Lobdell, Kamal Khabbaz, Edward Murphy, Robert C Hagberg
BACKGROUND: The goal of this study was to compare early postoperative outcomes and actuarial-free survival between patients who underwent repair of acute type A aortic dissection by the method of cerebral perfusion used. METHODS: A total of 324 patients from five academic medical centers underwent repair of acute type A aortic dissection between January 2000 and December 2010. Of those, antegrade cerebral perfusion (ACP) was used for 84 patients, retrograde cerebral perfusion (RCP) was used for 55 patients, and deep hypothermic circulatory arrest (DHCA) was used for 184 patients during repair...
July 2016: Annals of Cardiothoracic Surgery
Madeleine J Oudin, Miles A Miller, Joelle A Z Klazen, Tatsiana Kosciuk, Alisha Lussiez, Shannon K Hughes, Jenny Tadros, James E Bear, Douglas A Lauffenburger, Frank B Gertler
Directed cell migration, a key process in metastasis, arises from the combined influence of multiple processes, including chemotaxis-the directional movement of cells to soluble cues-and haptotaxis-the migration of cells on gradients of substrate-bound factors. However, it is unclear how chemotactic and haptotactic pathways integrate with each other to drive overall cell behavior. Mena(INV) has been implicated in metastasis by driving chemotaxis via dysregulation of phosphatase PTP1B and more recently in haptotaxis via interaction with integrin α5β1...
October 15, 2016: Molecular Biology of the Cell
Zuo-Quan Zhao, Yong Yang, Wei Fang, Shuang Liu
INTRODUCTION: This study sought to evaluate a (99m)Tc-labeled trimeric cyclic RGD peptide ((99m)Tc-4P-RGD3) as the new radiotracer for tumor imaging. The objective was to compare its biological properties with those of (99m)Tc-3P-RGD2 in the same animal model. METHODS: HYNIC-4P-RGD3 was prepared by reacting 4P-RGD3 with excess HYNIC-OSu in the presence of diisopropylethylamine. (99m)Tc-4P-RGD3 was prepared using a kit formulation, and evaluated for its tumor-targeting capability and biodistribution properties in the BALB/c nude mice with U87MG human glioma xenografts...
February 27, 2016: Nuclear Medicine and Biology
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