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https://www.readbyqxmd.com/read/28732401/can-brook-trout-survive-climate-change-in-large-rivers-if-it-rains
#1
Eric R Merriam, Rodrigo Fernandez, J Todd Petty, Nicolas Zegre
We provide an assessment of thermal characteristics and climate change vulnerability for brook trout (Salvelinus fontinalis) habitats in the upper Shavers Fork sub-watershed, West Virginia. Spatial and temporal (2001-2015) variability in observed summer (6/1-8/31) stream temperatures was quantified in 23 (9 tributary, 14 main-stem) reaches. We developed a mixed effects model to predict site-specific mean daily stream temperature from air temperature and discharge and coupled this model with a hydrologic model to predict future (2016-2100) changes in stream temperature under low (RCP 4...
July 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28715227/balancing-passive-and-active-targeting-to-different-tumor-compartments-using-riboflavin-functionalized-polymeric-nanocarriers
#2
Yoanna Tsvetkova, Nataliia Beztsinna, Maike Baues, Dionne Klein, Anne Rix, Susanne Katherina Golombek, Wa'el Al Rawashdeh, Felix Gremse, Matthias Barz, Kaloian Koynov, Srinivas Banala, Wiltrud Lederle, Twan Lammers, Fabian Kiessling
Riboflavin Transporters (RFTs) and the Riboflavin Carrier Protein (RCP) are highly upregulated in many tumor cells, tumor stem cells and tumor neovasculature, which makes them attractive targets for nanomedicines. Addressing cells in different tumor compartments requires drug carriers, which are not only able to accumulate via the EPR effect, but also to extravasate, target specific cell populations, and get internalized by cells. Reasoning that antibodies are among the most efficient targeting systems developed by nature, we consider their size (~10-15 nm) to be ideal for balancing passive and active tumor targeting...
July 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/28707573/synthesis-radiosynthesis-and-metabolism-of-131i-y-c-cgrraggsc
#3
Jilai Xie, Donghui Pan, Mudan Lu, Xuan Chen, Yu Chen, Ting Zhang, Yan Xie, Huan Zhou, Lu Liu, Min Yang, Jiajun Wang, Daozhen Chen
BACKGROUND: The formation of the complex interleukin-11(IL-11) and IL-11 receptor (IL-11R) is closely related with tumor progression. Binding of IL-11 to the IL-11 receptor α-chain (IL-11Rα) has been suggested as a target for human cancer. The cyclic peptide c(CGRRAGGSC) is a mimic of IL-11. OBJECTIVE: To explore 131I-Y-c(CGRRAGGSC) synthesis and radiosynthesis, and metabolism in SKOV3 tumor-bearing mice. METHOD: In this study, 131I labeled c(CGRRAGGSC) was designed and characterized...
July 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28705928/miniaturized-radiochemical-purity-testing-for-99m-tc-hmpao-99m-tc-hmdp-and-99m-tc-tetrofosmin
#4
Ana de la Fuente, Roberta Zanca, Angela Gabriella Cataldi, Roberto Boni, Martina Sollini, Elena Lazzeri, Giuliano Mariani, Paola Anna Erba
Quick methods are functional in clinical practice in order to ensure the fastest availability of radiopharmaceuticals. For this purpose, we investigated the radiochemical purity of the widely used (99m)Tc-HMDP (hydroxymethylene diphosphonate), (99m)Tc-HMPAO (hexamethylpropyleneamine oxime) and (99m)Tc-Tetrofosmin by reducing time as compared to the manufacturer's method. Methods: We applied a miniaturized chromatographic method with a reduced strip development from 18 cm to 9 cm for all three radiopharmaceuticals...
July 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28704433/forecasting-distributions-of-an-aquatic-invasive-species-nitellopsis-obtusa-under-future-climate-scenarios
#5
Daniel Romero-Alvarez, Luis E Escobar, Sara Varela, Daniel J Larkin, Nicholas B D Phelps
Starry stonewort (Nitellopsis obtusa) is an alga that has emerged as an aquatic invasive species of concern in the United States. Where established, starry stonewort can interfere with recreational uses of water bodies and potentially have ecological impacts. Incipient invasion of starry stonewort in Minnesota provides an opportunity to predict future expansion in order to target early detection and strategic management. We used ecological niche models to identify suitable areas for starry stonewort in Minnesota based on global occurrence records and present-day and future climate conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28697493/does-the-margin-matter-in-esophageal-cancer
#6
Karl-Frederick Karstens, Jakob R Izbicki, Matthias Reeh
BACKGROUND: The prognostic impact of circumferential resection margin (CRM) involvement in resected esophageal cancer (EC) is controversial discussed. The College of American Pathologists (CAP) and the Royal College of Pathologists (RCP) provide 2 different definitions of CRM involvement. The aim of this systematic review was to evaluate the clinical significance of CRM involvement on patients' survival following esophagectomy due to EC. METHODS: PubMed, Science Direct, and Google scholar were searched for studies analyzing the clinical impact of CRM in EC...
July 12, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28692285/raman-optical-activity-reveals-carotenoid-photoactivation-events-in-the-orange-carotenoid-protein-in-solution
#7
Tomotsumi Fujisawa, Ryan L Leverenz, Momoka Nagamine, Cheryl A Kerfeld, Masashi Unno
The orange carotenoid protein (OCP) plays an important role in photoprotection in cyanobacteria, which is achieved by the photoconversion from the orange dark state (OCPO) to the red active state (OCPR). Using Raman optical activity (ROA), we studied the conformations of the carotenoid chromophore in the active sites of OCPO and OCPR. This ROA measurement directly observed the chromophore conformation of native OCP in solution, and the measurement of OCPR first demonstrated the ROA spectroscopy for the transient species...
July 10, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28686197/vulnerability-reduction-needed-to-maintain-current-burdens-of-heat-related-mortality-in-a-changing-climate-magnitude-and-determinants
#8
Christofer Åström, Daniel Oudin Åström, Camilla Andersson, Kristie L Ebi, Bertil Forsberg
The health burden from heatwaves is expected to increase with rising global mean temperatures and more extreme heat events over the coming decades. Health-related effects from extreme heat are more common in elderly populations. The population of Europe is rapidly aging, which will increase the health effects of future temperatures. In this study, we estimate the magnitude of adaptation needed to lower vulnerability to heat in order to prevent an increase in heat-related deaths in the 2050s; this is the Adaptive Risk Reduction (ARR) needed...
July 7, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28683431/modeling-and-projection-of-dengue-fever-cases-in-guangzhou-based-on-variation-of-weather-factors
#9
Chenlu Li, Xiaofeng Wang, Xiaoxu Wu, Jianing Liu, Duoying Ji, Juan Du
Dengue fever is one of the most serious vector-borne infectious diseases, especially in Guangzhou, China. Dengue viruses and their vectors Aedes albopictus are sensitive to climate change primarily in relation to weather factors. Previous research has mainly focused on identifying the relationship between climate factors and dengue cases, or developing dengue case models with some non-climate factors. However, there has been little research addressing the modeling and projection of dengue cases only from the perspective of climate change...
July 3, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28678192/quantifying-projected-heat-mortality-impacts-under-21st-century-warming-conditions-for-selected-european-countries
#10
Vladimir Kendrovski, Michela Baccini, Gerardo Sanchez Martinez, Tanja Wolf, Elizabet Paunovic, Bettina Menne
Under future warming conditions, high ambient temperatures will have a significant impact on population health in Europe. The aim of this paper is to quantify the possible future impact of heat on population mortality in European countries, under different climate change scenarios. We combined the heat-mortality function estimated from historical data with meteorological projections for the future time laps 2035-2064 and 2071-2099, developed under the Representative Concentration Pathways (RCP) 4.5 and 8.5...
July 5, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28674603/mathematical-modeling-and-expression-of-heart-rate-deflection-point-using-heart-rate-and-oxygen-consumption
#11
Kayla M Baker, David H Fukuda, David D Church, Michael B LA Monica, Kyle S Beyer, Jay R Hoffman, Jeffrey R Stout
Heart rate deflection point (HRDP) can be determined through different mathematical-modeling procedures, such as bi-segmental linear regression (2SEG) or maximal distance model (Dmax). The purpose was to compare heart rate (HR) and oxygen consumption (VO2) at HRDP when using 2SEG and Dmax, and to examine their relationships with respiratory compensation point (RCP) and running performance. Nineteen participants completed a graded exercise test (GXT), to determine HRDP and RCP, and a 5km treadmill time trial (5Ktime)...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28671853/physiological-and-anthropometric-characteristics-of-top-level-youth-cross-country-cyclists
#12
Alessandro Fornasiero, Aldo Savoldelli, Roberto Modena, Gennaro Boccia, Barbara Pellegrini, Federico Schena
In the literature there is a lack of data about the development of top level athletes in cross-country mountain biking (XCO). The purpose of this study was to analyze anthropometric and physiological characteristics of some of the best XCO bikers aged between 13 and 16. The study involved 45 bikers (26 males and 19 females) belonging to a youth national team. The evaluations, consisting of anthropometric measures, incremental cycling tests (VO2max, PPO, P@RCP), and 30 s Wingate Tests (PMax, PMean), were conducted over a lapse of 4 years...
July 3, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28665883/optimizing-linkage-to-care-and-initiation-and-retention-on-treatment-of-adolescents-with-newly-diagnosed-hiv-infection
#13
Eva Caroline Ruria, Rose Masaba, Judith Kose, Godfrey Woelk, Eliud Mwangi, Lucy Matu, Hillary Ng'eno, Beatrice Bikeri, Natella Rakhmanina
OBJECTIVE: Unsuccessful linkage to care and treatment increases adolescent HIV-related morbidity and mortality. This study evaluated the effect of a novel adolescent and youth Red Carpet Program (RCP) on the timing and outcomes of linkage to care. DESIGN: A prepost implementation evaluation of the pilot RCP program. SETTINGS: Healthcare facilities (HCFs) and schools in Homa Bay County, Kenya. STUDY PARTICIPANTS: HIV-infected adolescents (15-19 years) and youth (20-21 years)...
July 1, 2017: AIDS
https://www.readbyqxmd.com/read/28641812/continuum-based-models-and-concepts-for-the-transport-of-nanoparticles-in-saturated-porous-media-a-state-of-the-science-review
#14
REVIEW
Peyman Babakhani, Jonathan Bridge, Ruey-An Doong, Tanapon Phenrat
Environmental applications of nanoparticles (NP) increasingly result in widespread NP distribution within porous media where they are subject to various concurrent transport mechanisms including irreversible deposition, attachment/detachment (equilibrium or kinetic), agglomeration, physical straining, site-blocking, ripening, and size exclusion. Fundamental research in NP transport is typically conducted at small scale, and theoretical mechanistic modeling of particle transport in porous media faces challenges when considering the simultaneous effects of transport mechanisms...
June 7, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28638254/inflammation-and-oxidation-biomarkers-in-patients-with-cystic-fibrosis-the-influence-of-azithromycin
#15
Casilda Olveira, Alicia Padilla, Antonio Dorado, Victoria Contreras, Eduardo Garcia-Fuentes, Elehazara Rubio-Martin, Nuria Porras, Esperanza Doña, Ana Carmona, Gabriel Olveira
OBJECTIVE: In addition to their antibiotic effect, macrolides appear to modulate the inflammatory response in cystic fibrosis (CF) and could influence oxidative stress. The objective of this study was to assess oxidation biomarkers and levels of inflammation and to determine whether there is an association between these parameters and the intake of macrolides. MATERIALS AND METHODS: The subjects included in this cross-sectional study were, on the one hand, clinically stable patients with CF and, on the other, healthy controls...
June 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28637399/biomineralized-recombinant-collagen-based-scaffold-mimicking-native-bone-enhances-mesenchymal-stem-cell-interaction-and-differentiation
#16
Gloria Belén Ramirez-Rodríguez, Monica Montesi, Silvia Panseri, Simone Sprio, Anna Tampieri, Monica Sandri
The need of synthetic bone grafts that recreate from macro to nanoscale level the biochemical and biophysical cues of bone extracellular matrix (ECM) has been a major driving force for the development of new generation of biomaterials. In this study, synthetic bone substitutes have been synthesized via biomimetic mineralization of a recombinant collagen type I derived peptide (RCP), enriched in tri-amino acid sequence arginine-glycine-aspartate (RGD). 3D isotropic porous scaffolds of three different compositions are developed by freeze-drying: non-mineralized (RCP, as a control), mineralized (Ap/RCP) and mineralized scaffolds in presence of magnesium (MgAp/RCP) that closely imitate bone composition...
June 22, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28634404/modelled-responses-of-the-kalahari-desert-to-21-st-century-climate-and-land-use-change
#17
Jerome R Mayaud, Richard M Bailey, Giles F S Wiggs
Drylands are home to over 2 billion people globally, many of whom use the land for agricultural and pastoral activities. These vulnerable livelihoods could be disrupted if desert dunefields become more active in response to climate and land use change. Despite increasing knowledge about the role that wind, moisture availability and vegetation cover play in shaping dryland landscapes, relatively little is known about how drylands might respond to climatic and population pressures over the 21(st) century. Here we use a newly developed numerical model, which fully couples vegetation and sediment-transport dynamics, to simulate potential landscape evolution at three locations in the Kalahari Desert, under two future emissions scenarios: stabilising (RCP 4...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28630444/modelling-the-effects-of-global-climate-change-on-chikungunya-transmission-in-the-21-st-century
#18
Nils B Tjaden, Jonathan E Suk, Dominik Fischer, Stephanie M Thomas, Carl Beierkuhnlein, Jan C Semenza
The arrival and rapid spread of the mosquito-borne viral disease Chikungunya across the Americas is one of the most significant public health developments of recent years, preceding and mirroring the subsequent spread of Zika. Globalization in trade and travel can lead to the importation of these viruses, but climatic conditions strongly affect the efficiency of transmission in local settings. In order to direct preparedness for future outbreaks, it is necessary to anticipate global regions that could become suitable for Chikungunya transmission...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28625315/cancer-de-l%C3%A2-ovaire-prise-en-charge-pluridisciplinaire-du-cancer-de-l%C3%A2-ovaire-en-premi%C3%A3-re-ligne-recommandations-saint-paul-de-vence-2016
#19
Jean-Marc Classe, Frédéric Guyon, Claire Falandry, Mojgan Devouassoux-Shisheboran, Frédéric Selle, Florence Joly
Recommendations for the clinical practice of Nice-Saint-Paul de Vence The treatment of advanced epithelial ovarian cancer is multidisciplinary involving surgical teams and surgery and medical oncology, experienced in the management of this disease, following published quality criteria. The strategy must be validated in multidisciplinary consultation meeting (RCP) before any treatment. The pre-therapeutic assessment includes the histological diagnosis, evaluation of the tumor extension (biological assessment, markers, imaging, laparoscopy), assessment of the general state (operability), in order to answer the question of feasibility of an initial optimal surgery...
May 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28605611/short-and-long-term-bond-strength-between-resin-cement-and-glass-ceramic-using-a-silane-containing-universal-adhesive
#20
F Murillo-Gómez, F A Rueggeberg, M F De Goes
This study aimed to evaluate the effect of various silane-containing solutions on bonding between resin cement and glass ceramic after 24 hours and after six months of water storage. Glass-ceramic plaques (IPS e.max CAD) were sandblasted with aluminum oxide, etched with 10% hydrofluoric acid (HF), and divided into five "silane treatment" groups: RelyX Ceramic Primer (RCP), RelyX Ceramic Primer and Single Bond Plus (RCP+SB), Scotchbond Universal (SBU), Clearfil Ceramic Primer (CP), and no solution (HF-only control)...
June 12, 2017: Operative Dentistry
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