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Spectral CT

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https://www.readbyqxmd.com/read/28640302/influence-of-substituents-on-dna-and-protein-binding-of-cyclometalated-ir-iii-complexes-and-anticancer-activity
#1
Sujay Mukhopadhyay, Roop Shikha Singh, Rajendra Prasad Paitandi, Gunjan Sharma, Biplob Koch, Daya Shankar Pandey
Synthesis of terpyridyl based ligands 3-([2,2':6',2''-terpyridin]-4'-yl)-7-methoxy-2-(methylthio)-quinolone, (L1); 3-([2,2':6',2''-terpyridin]-4'-yl)-6-methoxyquinolin-2(1H)-one, (L2); 3-([2,2'-:6',2''-terpyridin]-4'-yl)-6-methylquinolin-2(1H)-one (L3) and cyclometalated iridium(iii) complexes [[Ir(ppy)2L1](+)PF6(-) (1), [Ir(ppy)2L2](+)PF6(-) (2), [Ir(ppy)2L3](+)PF6(-) (3) (2-phenylpyridine = Hppy)] involving these ligands has been described. The ligands L1-L3 and complexes 1-3 have been thoroughly characterized by elemental analyses, spectral studies (IR, (1)H, (13)C NMR, UV/vis and fluorescence) ESI-MS, and the structure of 3 has been unambiguously authenticated by single crystal X-ray analyses...
June 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28632403/effect-of-amblyopia-treatment-on-choroidal-thickness-in-children-with-hyperopic-anisometropic-amblyopia
#2
Seray Aslan Bayhan, Hasan Ali Bayhan
PURPOSE: To evaluate choroidal thickness (CT) in the eyes of children with hyperopic anisometropic amblyopia and to assess changes in CT during amblyopia treatment using spectral-domain optical coherence tomography (SD-OCT). METHODS: This longitudinal study, initially enrolled 40 patients, aged 3-9 years with hyperopic anisometropic amblyopia. Patients underwent treatment with refractive correction alone for 16 weeks and if needed, with refractive correction and patching treatment thereafter (6 months)...
June 20, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28629567/ct-coronary-calcium-scoring-with-tin-filtration-using-iterative-beam-hardening-calcium-correction-reconstruction
#3
Christian Tesche, Carlo N De Cecco, U Joseph Schoepf, Taylor M Duguay, Moritz H Albrecht, Domenico De Santis, Akos Varga-Szemes, Virginia W Lesslie, Ullrich Ebersberger, Richard R Bayer, Christian Canstein, Ellen Hoffmann, Thomas Allmendinger, John W Nance
OBJECTIVES: To investigate the diagnostic accuracy of CT coronary artery calcium scoring (CACS) with tin pre-filtration (Sn100kVp) using iterative beam-hardening correction (IBHC) calcium material reconstruction compared to the standard 120kVp acquisition. BACKGROUND: Third generation dual-source CT (DSCT) CACS with Sn100kVp acquisition allows significant dose reduction. However, the Sn100kVp spectrum is harder with lower contrast compared to 120kVp, resulting in lower calcium score values...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28628906/quadrupolar-nutation-nmr-to-discriminate-central-and-satellite-transitions-spectral-assignments-for-a-ziegler-natta-catalyst
#4
E S Merijn Blaakmeer, Wouter M J Franssen, Arno P M Kentgens
In this contribution we used solid state (35)Cl (I=3/2) quadrupolar NMR to study a MgCl2/2,2-dimethyl-1,3-dimethoxypropane (DMDOMe) adduct that serves as a model system for Ziegler-Natta catalysis. Employing large Radio-Frequency (RF) field strengths we observe three spectral features with strongly varying line widths. The assignment of the spectra is complicated because of the large difference in quadrupolar interactions experienced by the different sites in the system. The satellite transitions (ST) of relatively well-defined bulk Cl sites are partially excited and may overlap with the central transition (CT) resonances of more distorted surface sites...
June 7, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28624012/differentiation-of-small-intrahepatic-mass-forming-cholangiocarcinoma-from-small-liver-abscess-by-dual-source-dual-energy-ct-quantitative-parameters
#5
Ji Eun Kim, Hyun Ok Kim, Kyungsoo Bae, Jae Min Cho, Ho Cheol Choi, Dae Seob Choi
PURPOSE: To investigate the use of dual source dual-energy CT (DECT) quantitative parameters compared with the use of conventional CT for differentiating small (≤3cm) intrahepatic mass-forming cholangiocarcinoma (IMCC) from small liver abscess (LA) during the portal venous phase (PVP). MATERIAL AND METHODS: In this institutional review board-approved, retrospective study, 64 patients with IMCCs and 52 patients with LAs who were imaged in PVP using dual-energy mode were included retrospectively...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28621699/diagnostic-value-of-single-source-dual-energy-spectral-computed-tomography-for-papillary-thyroid-microcarcinomas
#6
Lin Li, Yong Wang, De-Hong Luo, Yan-Feng Zhao, Meng Lin, Wei Guo, Lei Hu, Chun-Wu Zhou, Xin-Ming Zhao
BACKGROUND: Ultrasound (US) and computed tomography (CT) are common diagnostic imaging methods for detecting and diagnosing papillary thyroid microcarcinoma (PTMC). However, single-source dual-energy spectral computed tomography (spectral CT) reduces beam hardening artefacts and optimizes contrast, which may add value in detecting PTMC. OBJECTIVE: To investigate values of applying single-source dual-energy spectral CT for diagnosing PTMCs, in comparison with high frequency ultrasound and conventional polychromatic images...
June 10, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/28617854/choroidal-thickness-in-school-children-the-gobi-desert-children-eye-study
#7
Dan Zhu, Yan Wang, Yan Fei Zheng, Da Yong Yang, Kai Guo, Xian Rong Yang, Xin Xia Jing, Ian Y Wong, Qi Sheng You, Yong Tao, Jost B Jonas
PURPOSE: To investigate choroidal thickness (CT) and its associations in children in a school-based study. METHODS: The cross-sectional school-based Gobi Desert Children Eye Study included 1565 out of 1911 (81.9%) eligible children from all schools in the oasis region of Ejina in the Gobi Desert. A detailed ophthalmic examination was performed, including spectral-domain optical coherence tomography with enhanced depth imaging for CT measurement. RESULTS: CT measurements were available for 1463 (93...
2017: PloS One
https://www.readbyqxmd.com/read/28600299/evaluation-of-optical-coherence-tomography-angiographic-findings-in-alzheimer-s-type-dementia
#8
Mehmet Bulut, Fatma Kurtuluş, Onursal Gözkaya, Muhammet Kazım Erol, Ayşe Cengiz, Melih Akıdan, Aylin Yaman
BACKGROUND/AIMS: To identify the retinal vascular pathologies in patients with Alzheimer's type dementia (ATD) through optical coherence tomography angiography (OCTA) imaging. METHODS: Our study included 26 patients in the patient group, and age-matched and sex-matched 26 subjects in the control group. A detailed ophthalmological and neurological examination was performed for all subjects included in the study. The retinal, choroidal vascular structures and choroidal thickness (CT) of all subjects were analysed in a detailed way with a commercial spectral domain OCTA...
June 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28587323/clinical-relevance-of-gemstone-spectral-ct-in-the-diagnosis-of-carotid-atherosclerosis
#9
Jing-Jian Wang, Shu-Jie Fan, Long-Long Wang, Yan-Zhong Gao, Xiao-Juan Liu
A variety of imaging methods can be used in the diagnosis of atherosclerotic plaques. In the present study, we investigated the morphology and composition of atherosclerotic plaque associated with ischemic cerebral infarction by comparing gemstone spectral computed tomography (GSCT) and traditional multi-slice CT (MSCT). In total, 200 patients were enrolled and divided into the experimental group (n=100), which underwent GSCT, and the control group (n=100), which underwent MSCT. All the cases were followed up to observe disease outcomes in patients with different atherosclerotic plaque types, and adverse events in carotid artery stenosis or cerebral infarction were recorded...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28583644/improved-detection-of-melanoma-metastases-by-iodine-maps-from-dual-energy-ct
#10
Monika Uhrig, David Simons, David Bonekamp, Heinz-Peter Schlemmer
OBJECTIVE: Metastatic disease in melanoma has an unpredictable nature with deposits in rare locations such as musculature. Dual energy CT (DECT) provides high contrast-visualization of enhancement by using spectral properties of iodine. Purpose of this study was to evaluate whether iodine maps from DECT improve lesion detection in staging examinations of melanoma patients. METHODS: This retrospective study was approved by IRB and written informed consent was obtained from all patients...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28579063/choroidal-changes-associated-with-subretinal-drusenoid-deposits-in-age-related-macular-degeneration-using-swept-source-oct
#11
Inês Laíns, Jay Wang, Joana Providência, Steven Mach, Pedro Gil, João Gil, Marco Marques, Grayson Armstrong, Shady Garas, Patrícia Barreto, Ivana K Kim, Demetrios G Vavvas, Joan W Miller, Deeba Husain, Rufino Silva, John B Miller
PURPOSE: To compare choroidal vascular features of eyes with and without subretinal drusenoid deposits (SDD), using swept-source optical coherence tomography (SS-OCT). DESIGN: Multicenter, cross-sectional study. METHODS: We prospectively recruited patients with intermediate age-related macular degeneration (AMD), without other vitreoretinal pathology. All participants underwent complete ophthalmic exam, color fundus photography (used for AMD staging), and spectral-domain OCT (to evaluate the presence of SDD)...
June 1, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28575934/dna-interaction-antioxidant-and-in-vitro-cytotoxic-activities-of-some-mononuclear-metal-ii-complexes-of-a-bishydrazone-ligand
#12
Chellaian Justin Dhanaraj, Jijo Johnson
A tridentate ONO donor bishydrazone ligand, 3-(((3-oxoindolin-2-ylidene)hydrazono) methyl)quinoxalin-2(1H)-one (L) was synthesized. Using the ligand, mononuclear metal complexes of the type [M(L)(OAc)] (M=Co(II), Ni(II), Cu(II) and Zn(II), OAc=-OCOCH3) were synthesized. The newly synthesized compounds were thoroughly characterized by various analytical and spectral techniques. Tetrahedral geometry was proposed for Co(II), Ni(II) and Zn(II) complexes, while square planar geometry has been assigned to the Cu(II) complex...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28572289/parametric-method-performance-for-dynamic-3-deoxy-3-18-f-fluorothymidine-pet-ct-in-epidermal-growth-factor-receptor-mutated-non-small-cell-lung-carcinoma-patients-before-and-during-therapy
#13
Gerbrand Maria Kramer, Virginie Frings, Dennis Heijtel, E F Smit, Otto S Hoekstra, Ronald Boellaard
The objective of this study was to validate several parametric methods for quantification of 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) PET in advanced-stage non-small cell lung carcinoma (NSCLC) patients with an activating epidermal growth factor receptor mutation who were treated with gefitinib or erlotinib. Furthermore, we evaluated the impact of noise on accuracy and precision of the parametric analyses of dynamic (18)F-FLT PET/CT to assess the robustness of these methods. Methods: Ten NSCLC patients underwent dynamic (18)F-FLT PET/CT at baseline and 7 and 28 d after the start of treatment...
June 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28560051/choroidal-vascular-analysis-in-myopic-eyes-evidence-of-foveal-medium-vessel-layer-thinning
#14
Rayan A Alshareef, Mohammed K Khuthaila, Manideepak Januwada, Abhilash Goud, Daniela Ferrara, Jay Chhablani
PURPOSE: To analyse morphologic features of the choroid in Non-pathological myopic eyes using spectral-domain (SD) optical coherence tomography (OCT). METHODS: Retrospective analysis of enhanced depth SD-OCT images of Non-pathological myopic eyes in comparison with age-matched healthy controls was performed. Choroidal thickness (CT) and large choroidal vessel thickness (LCVT) were measured at the fovea, 750 µm nasally from fovea (N(750)) and 750 µm temporally (T(750)) from fovea...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28544620/phenotyping-cardiac-and-structural-birth-defects-in-fetal-and-newborn-mice
#15
REVIEW
Xiaoqin Liu, Andrew J Kim, William Reynolds, Yijen Wu, Cecilia W Lo
Mouse models are invaluable for investigating the developmental etiology and molecular pathogenesis of structural birth defects. While this has been deployed for studying a wide spectrum of birth defects, mice are particularly valuable for modeling congenital heart disease, given they have the same four-chamber cardiac anatomy as in humans. We have developed the use of noninvasive fetal ultrasound together with micro-computed tomography (micro-CT) imaging for high throughput phenotyping of mice for congenital heart defects (CHD) and other developmental anomalies...
May 22, 2017: Birth defects research
https://www.readbyqxmd.com/read/28543774/spectral-signal-density-of-carotid-plaque-using-dual-energy-computed-tomography
#16
Exequiel Reynoso, Gastón A Rodriguez-Granillo, Carlos Capunay, Alejandro Deviggiano, Francisco Meli, Patricia Carrascosa
BACKGROUND AND PURPOSE: Plaque characterization using virtual monochromatic imaging derived from dual-energy computed tomography (CT) angiography requires the determination of normal signal density values of each plaque component. We sought to explore the signal density values of carotid plaque components using dual-energy compared to conventional single-energy CT angiography (CTA), and to establish the energy level with the largest differences between plaque components. METHODS: The present prospective study involved consecutive patients referred for carotid artery evaluation by CTA...
May 25, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28542096/modified-dual-energy-algorithm-for-calcified-plaque-removal-evaluation-in-carotid-computed-tomography-angiography-and-comparison-with-digital-subtraction-angiography
#17
Manoj Mannil, Jaychandran Ramachandran, Ilaria Vittoria de Martini, Susanne Wegener, Bernhard Schmidt, Thomas Flohr, Bernhard Krauss, Antonios Valavanis, Hatem Alkadhi, Sebastian Winklhofer
OBJECTIVES: Computed tomography angiography (CTA) is a valuable tool for the assessment of carotid artery stenosis. However, blooming artifacts from calcified plaques might result in an overestimation of the stenosis grade. The aim of this study was to investigate a new dual-energy computed tomography (DECT) technique with a modified 3-material decomposition algorithm for calcium removal in extracranial carotid artery stenosis. MATERIALS AND METHODS: In this retrospective, institutional review board-approved study, 30 calcified carotid plaques in 22 patients (15 men; mean age, 73 ± 10 years) with clinical suspicion of stroke were included...
May 24, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28540651/biologically-active-cu-ii-co-ii-ni-ii-and-zn-ii-complexes-of-pyrimidine-derivative-schiff-base-dna-binding-antioxidant-antibacterial-and-in-vitro-anticancer-studies
#18
Nagaraj Revathi, Murugesan Sankarganesh, Jegathalaprathaban Rajesh, Jeyaraj Dhaveethu Raja
A new pyrimidine derivative Schiff base ligand (HL) [HL = 2-(4,6-dimethylpyrimidin-2-ylimino)methyl)-4-nitrophenol] and its metal(II) complexes [CuL2] (1), [CoL2] (2), [NiL2] (3) and [ZnL2] (4) have been synthesized and characterized by several spectral techniques. The square planar geometry of the complexes 1-4 confirmed by UV-Visible, ESR and EI-mass spectral techniques. DNA binding study of the complexes 1-4 with Calf Thymus (CT) DNA using absorption spectral titration at different pH (4.0, 7.0 & 10.0) have been scrutinized that the complexes 1-4 bound by groove binding mode with significant binding constant values (K b  = 5...
May 24, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28536753/differentiation-of-clot-composition-using-conventional-and-dual-energy-computed-tomography
#19
Jan Borggrefe, Jonathan Kottlors, Mahmood Mirza, Victor-Frederic Neuhaus, Nuran Abdullayev, Volker Maus, Christoph Kabbasch, David Maintz, Anastasios Mpotsaris
BACKGROUND AND PURPOSE: In unenhanced computed tomography (CT) of acute ischemic stroke, the density of occluding clots is associated with the content of red blood cells and successful recanalization with stent thrombectomy. However, no CT marker for fibrin content is established. In order to improve clot diagnostics, we conducted an in vitro study to investigate thrombus composition of histologically defined ovine blood clots with unenhanced and contrast-enhanced CT using spectral detector CT (SDCT)...
May 23, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28522161/effect-of-blue-and-violet-light-on-polymerization-shrinkage-vectors-of-a-cq-tpo-containing-composite
#20
Camila S Sampaio, Pablo J Atria, Frederick A Rueggeberg, Satoshi Yamaguchi, Marcelo Giannini, Paulo G Coelho, Ronaldo Hirata, Regina M Puppin-Rontani
OBJECTIVE: To evaluate the effect of light-curing wavelengths on composite filler particle displacement, and thus to visualize localized polymerization shrinkage in a resin-based composite (RBC) containing camphorquinone (CQ) and Lucirin TPO (TPO). METHODS: Three light-curing units (LCUs) were used to light-cure a RBC containing CQ and TPO: a violet-only, a blue-only, and a dual-wavelength, conventional (Polywave(®), emitting violet and blue wavelengths simultaneously)...
May 15, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
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