keyword
https://read.qxmd.com/read/38597530/post-partum-weight-retention-in-northeastern-brazilian-women-a-prospective-nisami-cohort-study
#21
JOURNAL ARTICLE
Sheila Monteiro Brito, Jerusa da Mota Santana, Marcos Pereira, Djanilson Barbosa Santos, Ana Marlucia Oliveira
BACKGROUND: Weight retention during the post-partum period is associated with excessive weight gain. OBJECTIVES: To investigate factors associated with maternal weight retention at six months post-partum (PPWR). DESIGN AND SETTING: A prospective cohort study was conducted with 127 women monitored using prenatal services. METHODS: The outcome variable was represented by post-partum maternal weight retention and calculated as the difference between the mother's weight at sixth month post-partum and her pregestational weight...
2024: São Paulo Medical Journal
https://read.qxmd.com/read/38597246/phosphorus-ligand-redox-cooperative-catalysis-unraveling-four-electron-dioxygen-reduction-pathways-and-reactive-intermediates
#22
JOURNAL ARTICLE
Sung Gyu Kim, Dongyoung Kim, Jinrok Oh, Yeong Jun Son, Sangmin Jeong, Joonghan Kim, Seung Jun Hwang
The reduction of dioxygen to water is crucial in biology and energy technologies, but it is challenging due to the inertness of triplet oxygen and complex mechanisms. Nature leverages high-spin transition metal complexes for this, whereas main-group compounds with their singlet state and limited redox capabilities exhibit subdued reactivity. We present a novel phosphorus complex capable of four-electron dioxygen reduction, facilitated by unique phosphorus-ligand redox cooperativity. Spectroscopic and computational investigations attribute this cooperative reactivity to the unique electronic structure arising from the geometry of the phosphorus complex bestowed by the ligand...
April 10, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38596515/evaluation-of-sinergiaps-an-intervention-to-improve-patient-safety-in-primary-healthcare-centers-in-spain-based-on-patients-perceptions-and-experiences-a-protocol-for-a-hybrid-type-i-randomized-clinical-trial
#23
JOURNAL ARTICLE
Maria A Fiol-deRoque, Georgina Vidal Mansilla, José A Maderuelo-Fernández, Olaya Tamayo-Morales, Francisco Martín-Luján, Pilar Astier-Peña, Macarena Chacón-Docampo, Carola Orrego, Montserrat Gens-Barberà, Pilar Andreu-Rodrigo, Ignacio Ricci-Cabello
BACKGROUND: Adverse events in the primary care setting result in a direct cost equivalent to at least 2.5% of total healthcare spending. Across OECD countries, they lead to more than seven million avoidable hospital admissions annually. In this manuscript, we describe the protocol of a trial aimed at evaluating the effectiveness of SinergiAPS (a patient-centered audit and feedback intervention) in reducing avoidable hospital admission and explore the factors that may affect its implementation...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38596068/point-of-care-circulating-cathodic-antigen-positivity-and-associated-factors-in-school-children-one-year-after-mass-praziquantel-administration-in-an-endemic-district-in-ghana
#24
JOURNAL ARTICLE
Isaac Tukwarlba, Enoch Aninagyei, Puopelle Dakorah Mavis, Juliana Attoh, Kwabena Obeng Duedu, Justice Kumi, Eunice Ampem-Danso, Desmond Omane Acheampong
BACKGROUND: Mass drug administration of praziquantel is expected to reduce Schistosome carriage in treated children in endemic communities. However, the effectiveness of this annual exercise has not been assessed in Ghana. Therefore, this study aimed to detect viable Schistosoma mansoni infection using point-of-care circulating cathodic antigen (POC-CCA) positivity as proxy and associated factors in children previously treated with praziquantel in an endemic municipality in Ghana. MATERIALS AND METHODS: This cross-sectional study was done in the Assin Central municipality in the Central Region of Ghana...
April 15, 2024: Heliyon
https://read.qxmd.com/read/38595156/repeatability-of-online-circular-contrast-perimetry-compared-to-standard-automated-perimetry
#25
JOURNAL ARTICLE
Joshua Meyerov, Yang Chen, Lazar Busija, Catherine Green, Simon E Skalicky
PRCIS: Online circular contrast perimetry has good test repeatability and reliability that is comparable with standard automated perimetry. It holds promise for use in disease screening and surveillance to expand the provision of glaucoma care. PURPOSE: To evaluate the repeatability of online circular contrast perimetry (OCCP) compared to standard automated perimetry (SAP) in normal participants and patients with stable glaucoma over 18 weeks. METHODS: Thirty-six participants (13 normal controls and 23 patients with open angle glaucoma) were recruited...
April 10, 2024: Journal of Glaucoma
https://read.qxmd.com/read/38594593/advanced-renal-cell-carcinoma-management-the-latin-american-cooperative-oncology-group-lacog-and-the-latin-american-renal-cancer-group-larcg-consensus-update
#26
REVIEW
Andrey Soares, Fernando Sabino Marques Monteiro, Karine Martins da Trindade, Adriano Gonçalves E Silva, Ana Paula Garcia Cardoso, André Deeke Sasse, André P Fay, André Paternò Castello Dias Carneiro, Antonio Machado Alencar Junior, Augusto César de Andrade Mota, Bruno Santucci, Daniel da Motta Girardi, Daniel Herchenhorn, Daniel Vilarim Araújo, Denis Leonardo Jardim, Diogo Assed Bastos, Diogo Rodrigues Rosa, Fabio A Schutz, Fábio Roberto Kater, Felipe da Silva Marinho, Fernando Cotait Maluf, Fernando Nunes Galvão de Oliveira, Fernando Vidigal, Igor Alexandre Protzner Morbeck, Jose Augusto Rinck Júnior, Leonardo Atem G A Costa, Manuel Caitano Dias Ferreira Maia, Manuela Zereu, Marcelo Roberto Pereira Freitas, Mariane Sousa Fontes Dias, Milena Shizue Tariki, Pamela Muniz, Patrícia Medeiros Milhomem Beato, Paulo Sérgio Moraes Lages, Pedro Isaacsson Velho, Ricardo Saraiva de Carvalho, Rodrigo Coutinho Mariano, Sandro Roberto de Araújo Cavallero, Thiago Martins Oliveira, Vinicius Carrera Souza, Oren Smaletz, Stênio de Cássio Zequi
PURPOSE: Renal cell carcinoma is an aggressive disease with a high mortality rate. Management has drastically changed with the new era of immunotherapy, and novel strategies are being developed; however, identifying systemic treatments is still challenging. This paper presents an update of the expert panel consensus from the Latin American Cooperative Oncology Group and the Latin American Renal Cancer Group on advanced renal cell carcinoma management in Brazil. METHODS: A panel of 34 oncologists and experts in renal cell carcinoma discussed and voted on the best options for managing advanced disease in Brazil, including systemic treatment of early and metastatic renal cell carcinoma as well as nonclear cell tumours...
April 9, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38593953/osteopetrosis-and-related-osteoclast-disorders-in-adults-a-review-and-knowledge-gapson-behalf-of-the-european-calcified-tissue-society-and-ern-bond
#27
JOURNAL ARTICLE
Thomas Funck-Brentano, M Carola Zillikens, Gavin Clunie, Heide Siggelkow, Natasha M Appelman-Dijkstra, Martine Cohen-Solal
Osteopetrosis refers to a group of related rare bone diseases characterized by a high bone mass due to impaired bone resorption by osteoclasts. Despite the high bone mass, skeletal strength is compromised and the risk of fracture is high, particularly in the long bones. Osteopetrosis was classically categorized by inheritance pattern into autosomal recessive forms (ARO), which are severe and diagnosed within the first years of life, an intermediate form and an autosomal dominant (ADO) form; the latter with variable clinical severity and typically diagnosed during adolescence or in young adulthood...
April 7, 2024: European Journal of Medical Genetics
https://read.qxmd.com/read/38592256/quality-improvement-in-anesthetic-management-of-patients-with-left-ventricular-assist-device-support-presenting-for-non-cardiac-surgery-a-single-center-experience
#28
JOURNAL ARTICLE
Dana D Yahav-Shafir, Ascher Jekutiel Gérard Schmelczer, Jonathan Frogel, Ilya Matskovsky, Amir Zabida, Jonathan Eisenberger, Jeffrey A Morgan
With the growing number of left ventricular assist device (LVAD) recipients requiring non-cardiac surgery and the limited availability of cardiac anesthesiologists, our study reviewed non-cardiac surgeries in HeartMate III patients with LVAD at our institution. We focused on anesthesiologist roles, detailing patient characteristics, anesthetic management, and outcomes and identifying improvement opportunities in this specialized care setting. A retrospective chart review was conducted of all patients with LVAD who underwent non-cardiac surgery at our institution between 2017 and 2022...
February 29, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38590395/association-between-cardiovascular-health-status-and-healthcare-utilization-in-a-large-integrated-healthcare-system
#29
JOURNAL ARTICLE
Irvin Lien, Howard Moffet, Jennifer Liu, Andrew Karter, Matthew Solomon, Alan Go, Khurram Nasir, Stephen Sidney, Jamal Rana
INTRODUCTION: The American Heart Association Life's Simple 7 schema can be used to categorize patients' cardiovascular health status as poor, intermediate, or ideal on the basis of smoking, BMI, physical activity, dietary patterns, blood pressure, cholesterol, and fasting blood sugar. This study examined the association between cardiovascular health status and subsequent healthcare utilization. METHODS: This was an observational cohort study of adults from an integrated healthcare delivery system-Kaiser Permanente Northern California-that had outpatient care between 2013 and 2014...
June 2024: AJPM Focus
https://read.qxmd.com/read/38590347/one-step-flow-synthesis-of-size-controlled-polymer-nanogels-in-a-fluorocarbon-microfluidic-chip
#30
JOURNAL ARTICLE
Reynaldo Carlos K Montalbo, Meng-Jie Wu, Hsiung-Lin Tu
Synthetic polymer nanoparticles (NPs) with biomimetic properties are ideally suited for different biomedical applications such as drug delivery and direct therapy. However, bulk synthetic approaches can suffer from poor reproducibility and scalability when precise size control or multi-step procedures are required. Herein, we report an integrated microfluidic chip for the synthesis of polymer NPs. The chip could sequentially perform homopolymer synthesis and subsequent crosslinking into NPs without intermediate purification...
April 3, 2024: RSC Advances
https://read.qxmd.com/read/38586539/health-related-quality-of-life-in-thai-patients-with-chronic-hepatitis-b
#31
JOURNAL ARTICLE
Ratthanan Chantrakul, Pimsiri Sripongpun, Tanawat Pattarapuntakul, Naichaya Chamroonkul, Chanon Kongkamol, Pochamana Phisalprapa, Apichat Kaewdech
BACKGROUND: Chronic hepatitis B (CHB) significantly impacts the health-related quality of life (HRQoL), but remains underexplored in the Thai population. Health state utilities (HSU) are indicators reflecting HRQoL which serve as fundamental inputs for economic evaluation analyses. This study aimed at assessing differences in HRQoL across five CHB stages in Thai patients, including non-cirrhotic CHB, compensated cirrhosis, decompensated cirrhosis, early-/intermediate-stage hepatocellular carcinoma (HCC) and advanced-/terminal-stage HCC...
2024: Gastroenterology Report
https://read.qxmd.com/read/38586432/accelerated-magnetocardiography-in-the-evaluation-of-patients-with-suspected-cardiac-ischemia-the-magneto-trial
#32
JOURNAL ARTICLE
Sharon E Mace, W Frank Peacock, Jason Stopyra, Simon A Mahler, Claire Pearson, Margarita Pena, Carol Clark
BACKGROUND: Diagnosing ischemia in emergency department (ED) patients with suspected acute coronary syndrome (sACS) is challenging with equivocal disposition of intermediate risk patients. OBJECTIVE: Compare sensitivity and specificity of magnetocardiography (MCG) versus standard of care (SOC) stress testing in diagnosing myocardial ischemia. METHODS: Multicenter, prospective, observational cohort study. ED patients with sACS and HEART score ≥ 3 underwent 90 s noninvasive MCG to detect myocardial ischemia...
April 2024: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38585321/effects-of-glycemic-variability-in-critically-ill-patients-with-coronavirus-disease-2019-a-retrospective-observational-study
#33
JOURNAL ARTICLE
Emerson Boschi, Gilberto Friedman, Rafael B Moraes
AIM AND BACKGROUND: Hyperglycemia is considered an adaptive metabolic manifestation of stress and is associated with poor outcomes. Herein, we analyzed the association between glycemic variability (GV) and hospital mortality in patients with coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU), and the association between GV and mechanical ventilation (MV), ICU stay, length of hospital stays, renal replacement therapy (RRT), hypoglycemia, nosocomial infections, insulin use, and corticosteroid class...
April 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38585153/impact-of-patient-centered-communication-on-patient-satisfaction-scores-in-patients-with-chronic-life-limiting-illnesses-an-experience-from-kenya
#34
JOURNAL ARTICLE
Betty Sirera, Violet Naanyu, Peter Kussin, David Lagat
BACKGROUND: Patient satisfaction remains a key area of interest worldwide; utilizing a patient-centered communication approach, particularly with patients with chronic life-limiting illnesses may be one way to achieve this. However, there is a dearth of empirical information on the effect of patient-centered communication strategies in patients with chronic life-limiting illnesses in Kenya on patient satisfaction. OBJECTIVES: The objective of this study was to assess the impact of patient-centered communication on patient satisfaction...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38583523/reducing-pediatric-mental-health-boarding-and-increasing-acute-care-access
#35
JOURNAL ARTICLE
Patricia Ibeziako, Katy Kaufman, Emily Campbell, Billy Zou, Chase Samsel, Zheala Qayyum, Annmarie Caracansi, Aliza Ray
OBJECTIVES: There have been notable increases pediatric mental health boarding in the United States in recent years, with youth remaining in emergency departments or admitted to inpatient medical/surgical units, awaiting placement at psychiatric treatment programs. We aimed to evaluate outcomes of interventions to reduce boarding and improve access to acute psychiatric services at a large tertiary pediatric hospital during a national pediatric mental health crisis. METHODS: Boarding interventions included expanding inpatient psychiatric beds and hiring additional staff for enhanced crisis stabilization services and treatment initiation in the emergency department and on inpatient medical/surgical units for boarding patients awaiting placement...
April 5, 2024: Journal of the Academy of Consultation—Liaison Psychiatry
https://read.qxmd.com/read/38583416/comparing-preoperative-screening-tools-for-elective-urologic-cancer-surgery-insights-from-a-cluster-analysis
#36
JOURNAL ARTICLE
Shugo Yajima, Yasukazu Nakanishi, Ryo Andy Ogasawara, Naoki Imasato, Kohei Hirose, Sao Katsumura, Madoka Kataoka, Hitoshi Masuda
INTRODUCTION: The aim of this study is to evaluate the features and benefits of different geriatric screening tools for enhancing the perioperative care of patients who undergo elective cancer surgery using cluster analysis. METHODS: This study was a retrospective, observational analysis of 1019 consecutive patients who had elective major cancer surgery in the urology department of our hospital from October 2019 to January 2023. Before the surgery, a trained nurse screened the patients using six tools: Eastern Clinical Oncology Group performance status (ECOG-PS), flemish version of the triage risk screening tool (fTRST), geriatric-8 (G8), instrumental activities of daily living (IADL), patient health questionnaire-2 (PHQ-2), and simple questionnaire to rapidly diagnose sarcopenia (SARC-F)...
April 5, 2024: Gerontology
https://read.qxmd.com/read/38582965/decoding-and-overcoming-t-cell-exhaustion-epigenetic-and-transcriptional-dynamics-in-car-t-cells-against-solid-tumors
#37
REVIEW
Taeyoung Ahn, Eun-Ah Bae, Hyungseok Seo
T cell exhaustion, which is observed in various chronic infections and malignancies, is characterized by elevated expression of multiple inhibitory receptors, impaired effector functions, decreased proliferation, and reduced cytokine production. Notably, while adoptive T cell therapies, such as chimeric antigen receptor (CAR)-T therapy, have shown promise in treating cancer and other diseases, the efficacy of these therapies is often compromised by T cell exhaustion. It is imperative, therefore, to understand the mechanisms underlying this exhaustion to promote advances in T cell-related therapies...
April 5, 2024: Molecular Therapy
https://read.qxmd.com/read/38582713/characterization-of-responses-to-lenvatinib-plus-pembrolizumab-in-patients-with-advanced-renal-cell-carcinoma-at-the-final-prespecified-survival-analysis-of-the-phase-3-clear-study
#38
JOURNAL ARTICLE
Robert J Motzer, Toni K Choueiri, Thomas Hutson, Sun Young Rha, Javier Puente, Aly-Khan A Lalani, Eric Winquist, Masatoshi Eto, Naveen S Basappa, Nizar M Tannir, Ulka Vaishampayan, Georg A Bjarnason, Stéphane Oudard, Viktor Grünwald, Joseph Burgents, Ran Xie, Jodi McKenzie, Thomas Powles
In the phase 3 CLEAR trial, lenvatinib plus pembrolizumab (L + P) showed superior efficacy versus sunitinib in treatment-naïve patients with advanced renal cell carcinoma (aRCC). The combination treatment was associated with a robust objective response rate of 71%. Here we report tumor responses for patients in the L + P arm in CLEAR, with median follow-up of ∼4 yr at the final prespecified overall survival (OS) analysis. Tumor responses were assessed by independent review using Response Evaluation Criteria in Solid Tumors v1...
April 5, 2024: European Urology
https://read.qxmd.com/read/38581198/prostate-specific-antigen-screening-and-15-year-prostate-cancer-mortality-a-secondary-analysis-of-the-cap-randomized-clinical-trial
#39
JOURNAL ARTICLE
Richard M Martin, Emma L Turner, Grace J Young, Chris Metcalfe, Eleanor I Walsh, J Athene Lane, Jonathan A C Sterne, Sian Noble, Peter Holding, Yoav Ben-Shlomo, Naomi J Williams, Nora Pashayan, Mai Ngoc Bui, Peter C Albertsen, Tyler M Seibert, Anthony L Zietman, Jon Oxley, Jan Adolfsson, Malcolm D Mason, George Davey Smith, David E Neal, Freddie C Hamdy, Jenny L Donovan
IMPORTANCE: The Cluster Randomized Trial of PSA Testing for Prostate Cancer (CAP) reported no effect of prostate-specific antigen (PSA) screening on prostate cancer mortality at a median 10-year follow-up (primary outcome), but the long-term effects of PSA screening on prostate cancer mortality remain unclear. OBJECTIVE: To evaluate the effect of a single invitation for PSA screening on prostate cancer-specific mortality at a median 15-year follow-up compared with no invitation for screening...
April 6, 2024: JAMA
https://read.qxmd.com/read/38581062/impact-of-environmental-factors-on-biomphalaria-pfeifferi-vector-capacity-leading-to-human-infection-by-schistosoma-mansoni-in-two-regions-of-western-c%C3%A3-te-d-ivoire
#40
JOURNAL ARTICLE
Edwige A Sokouri, Bernardin Ahouty Ahouty, Martial N'Djetchi, Innocent A Abé, Ble Gbacla Flora Dominique Yao, Thomas Konan Konan, Annette MacLeod, Harry Noyes, Oscar Nyangiri, Enock Matovu, Mathurin Koffi
UNLABELLED: ABSTRACT: BACKGROUND: Intestinal schistosomiasis remains a worrying health problem, particularly in western Côte d'Ivoire, despite control efforts. It is therefore necessary to understand all the factors involved in the development of the disease, including biotic and abiotic factors. The aim of this study was to examine the factors that could support the maintenance of the intermediate host and its vectorial capacity in western Côte d'Ivoire. METHODS: Data on river physicochemical, microbiological, and climatic parameters, the presence or absence of snails with Schistosoma mansoni, and human infections were collected between January 2020 and February 2021...
April 5, 2024: Parasites & Vectors
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