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Christopher P Parrish, Heidi Kim
PURPOSE OF REVIEW: This review aims to provide an update of recent advances in the epidemiology, clinical features and diagnosis, and management of food-induced anaphylaxis (FIA). RECENT FINDINGS: Food allergy prevalence and FIA rates continue to rise, but FIA fatalities are stable. Basophil and mast cell activation tests promise more accurate identification of food triggers. Oral, sublingual, and epicutaneous immunotherapy can desensitize a significant portion of subjects...
June 14, 2018: Current Allergy and Asthma Reports
Norihide Murayama, Kikuno Murayama
Food-dependent exercise-induced anaphylaxis (FDEIAn) is an anaphylactic reaction induced by physical exercise after ingestion of certain meals. FDEIAn is not very frequent, but recent case reports associated with various meals indicate an upward trend. Here, we report the data of various food specific IgEs and the clinical course of an experience with a patient who exhibited a unique FDEIAn reaction. Various food specific IgEs including staple food were positive with high levels. We could not find out the cause food of FDEIAn...
June 2018: Data in Brief
Jeffrey M Wilson, Anh T Nguyen, Alexander J Schuyler, Scott P Commins, Angela M Taylor, Thomas A E Platts-Mills, Coleen A McNamara
OBJECTIVE: Emerging evidence suggests a link between coronary artery disease and type 2 immunity. We sought to test the hypothesis that IgE sensitization to the mammalian oligosaccharide galactose-α-1,3-galactose (α-Gal)-the target allergen of delayed anaphylaxis to red meat-is associated with coronary artery disease. APPROACH AND RESULTS: Total IgE and specific IgE to α-Gal were assayed on sera from 118 subjects who presented for cardiac catheterization and underwent intravascular ultrasound...
June 14, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
Madoka Ihara, Yuhei Nojima, Tetsuya Kurimoto, Sinsuke Nanto, Hidenori Adachi
No abstract text is available yet for this article.
June 11, 2018: Journal of Allergy and Clinical Immunology in Practice
Yichen Xiao, Wenna Xu, Wenru Su
Allergic diseases, such as asthma, rhinitis, dermatitis, conjunctivitis, and anaphylaxis, have recently become a global public health concern. According to previous studies, the NLRP3 inflammasome is a multi-protein complex known to be associated with many inflammatory conditions. In response to allergens or allergen/damage-associated molecular signals, NLRP3 changes its conformation to allow the assembly of the NLRP3 inflammasome complex and activates caspase-1, which is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines IL-1β and IL-18...
June 13, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Christina J Jones, Lauren A Sommereux, Helen E Smith
BACKGROUND: Positive self-care behaviours are more likely in young people who engage with allergy support groups, but reasons for this association are not well understood. OBJECTIVES: This study explored how and why young people engage with allergy support groups to identify what activities and resources are beneficial. METHODS: In-depth, semi-structured interviews were conducted with young people aged 12-21 years who reported engaging with allergy support groups (in person or on-line)...
June 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Sachidanand Gautam, Anubhav Sharma
Human echinococcus is caused by tapeworm, Echinococcus granulosus , which forms larval cysts in the human tissue. Incidence in the cerebral form is only 1-2%. This localization can be associated with the involvement of other organs such as liver or lung or may be an isolated infestation of the brain or spinal column. Surgical removal of the intact and unruptured cyst is advised to prevent local recurrence that may require further surgery and long-term treatment with parasiticidal agents. We report three cases who presented with headache, vomiting, hemiparesis with decreased visual acuity, and convulsions...
January 2018: Journal of Pediatric Neurosciences
Leonardo Oliveira Mendonça, Cynthia Mafra Fonseca de Lima, Priscilla Rios Cordeiro Macedo, Victor do Espirito Santo Cunha, Ruppert Ludwig Hahnstadt, Jorge Kalil, Clóvis Eduardo Santos Galvão
CONTEXT: Adverse reactions associated with prick tests are rare but may be present as serious systemic reactions. CASE REPORT: A 38-year-old female nursing technician complained of three episodes of anaphylaxis in one year, all in the workplace. To investigate latex allergy, the patient underwent the prick test with latex, and immediately developed a rash, itchy skin, hoarseness, dyspnea and dry cough. Her condition improved promptly after appropriate measures were established for controlling her anaphylaxis...
June 11, 2018: São Paulo Medical Journal, Revista Paulista de Medicina
Deborah L McBride
Anaphylaxis, a sudden and potentially life-threatening allergic reaction, is increasing among children according to a new report. As the rate rises, there is an increased need for awareness and education for parents and caregivers to help them recognize and treat anaphylaxis. For children who do are at-risk of an anaphylactic reaction, parents and teachers need to be vigilant about the signs of anaphylaxis and to begin treatment quickly. The chances of a positive outcome are increased if necessary medications are on hand during a life-threatening situation...
June 9, 2018: Journal of Pediatric Nursing
Kazuhiko Ikeda, Hitoshi Ohto, Yoshiki Okuyama, Minami Yamada-Fujiwara, Heiwa Kanamori, Shin-Ichiro Fujiwara, Kazuo Muroi, Takehiko Mori, Kinuyo Kasama, Tohru Iseki, Tokiko Nagamura-Inoue, Nobuharu Fujii, Takashi Ashida, Kazuaki Kameda, Junya Kanda, Asao Hirose, Tsutomu Takahashi, Kazuhiro Nagai, Keiji Minakawa, Ryuji Tanosaki
Adverse events (AEs) associated with blood transfusions, including component-specific red cell, platelet, and plasma products, have been extensively surveyed. In contrast, surveillance of AEs associated with hematopoietic stem cell (HSC) products in HSC transplantation (HSCT) has been less rigorous, even though HSC products include a diversity of immature and mature hematopoietic cells, substantial plasma, and dimethyl sulfoxide (DMSO) in the case of cryopreserved HSC products. HSC infusion-related AEs have been attributed to DMSO toxicity, but AEs associated with the infusion of noncryopreserved HSC products are not uncommon...
June 1, 2018: Transfusion Medicine Reviews
Lin-Bo Shi, Hua-Ping Xu, Yu-Jie Wu, Xin Li, Jin-Yan Gao, Hong-Bing Chen
Low levels of endosulfan are known to stimulate mast cells to release allergic mediators, while imidacloprid can inhibit IgE-mediated mast cell degranulation. However, little information about the effects of both pesticides together on mast cell degranulation is available. To measure the effects, IgE-activated mouse bone marrow-derived mast cells (BMMCs) were treated with imidacloprid and endosulfan, individually, and simultaneously at equi-molar concentrations in tenfold steps ranging from 10-4 to 10-11  M, followed by measuring several allergy-related parameters expressed in BMMCs: the mediator production and influx of Ca2+ , the phosphorylation content of NF-κB in the FcεRI signaling pathway...
June 2018: Pesticide Biochemistry and Physiology
William L Walker, Susan L Hills, Elaine R Miller, Marc Fischer, Ingrid B Rabe
BACKGROUND: In March 2009, the U.S. Food and Drug Administration licensed an inactivated Vero cell culture-derived Japanese encephalitis vaccine (JE-VC [IXIARO®]) for use in persons aged ≥17 years. In 2013, licensure was extended to include children aged ≥2 months. A previous analysis reviewed adverse events reported to the U.S. Vaccine Adverse Event Reporting System (VAERS) from May 2009 through April 2012. METHODS: We reviewed adverse events reported to VAERS following JE-VC administered from May 1, 2012 through April 30, 2016...
June 8, 2018: Vaccine
Joan Bartra, Giovanna Araujo, Rosa Muñoz-Cano
PURPOSE OF REVIEW: To assess the studies that focus on the study of food-dependent exercise-induced anaphylaxis (FDEIA) and food-dependent NSAID-induced anaphylaxis (FDNIA). RECENT FINDINGS: Cofactors, as exercise and nonsteroidal anti-inflammatory drugs (NSAIDs), are relevant in up to 30% of episodes of anaphylaxis. Gliadin and lipid transfer proteins are the main allergens involved. The attempts to reproduce FDEIA and FDNIA in a controlled setting have an important failure rate...
June 7, 2018: Current Opinion in Allergy and Clinical Immunology
Louise Roper, Frances C Sherratt, Bridget Young, Paul McNamara, Angus Dawson, Richard Appleton, Esther Crawley, Lucy Frith, Carrol Gamble, Kerry Woolfall
OBJECTIVES: We explored children's views on research without prior consent (RWPC) and sought to identify ways of involving children in research discussions. DESIGN: Qualitative interview study. SETTING: Participants were recruited through a UK children's hospital and online advertising. PARTICIPANTS: 16 children aged 7-15 years with a diagnosis of asthma (n=14) or anaphylaxis (n=2) with recent (<12 months) experience of emergency care...
June 9, 2018: BMJ Open
Karla I Santos-Vigil, Damaris Ilhuicatzi-Alvarado, Ana L García-Hernández, Juan S Herrera-García, Leticia Moreno-Fierros
Cry1Ac toxin, from Bacillus thuringiensis, is widely used as a biopesticide and expressed in genetically modified (GM) plants used for human and animal consumption. Since Cry1Ac is also immunogenic and able to activate macrophages, it is crucial to thoroughly evaluate the immunological effects elicited after intra-gastric administration. The allergenic potential of purified Cry1Ac was assessed and compared with that induced in a murine model of food-allergy to ovalbumin (OVA), in which animals are sensitized with the adjuvant Cholera toxin (CT)...
June 7, 2018: International Immunopharmacology
Sandra Y Lin, Antoine Azar, Catalina Suarez-Cuervo, Gregory B Diette, Emily Brigham, Jessica Rice, Murugappan Ramanathan, Karen A Robinson
BACKGROUND: The purpose of the systematic review is to evaluate the efficacy and safety of sublingual immunotherapy (SLIT) for the treatment of allergic asthma. METHODS: PubMed, Embase, and CENTRAL databases were searched, updating an earlier review (January 1, 2005 through May 8, 2017). Randomized, controlled studies (RCTs) were included, which reported one of the prespecified outcomes: asthma symptoms measured by control composite scores; quality of life; medication use; pulmonary physiology; and health-care utilization...
June 9, 2018: International Forum of Allergy & Rhinology
Omar E Mohamed, Sarah Beck, Aarnoud Huissoon, Cathryn Melchior, Jane Heslegrave, Richard Baretto, Anjali Ekbote, Mamidipudi Thirumala Krishna
BACKGROUND: A spurious label of penicillin allergy (Pen-A) negatively impacts on antibiotic stewardship and healthcare costs. Recent studies have proposed a guideline-steered direct penicillin challenge without undertaking allergy tests when 'true allergy' is unlikely. OBJECTIVE: Critically analyse Pen-A clinical presentation, perform risk stratification and determine clinical predictors for 'true allergy'. METHOD: Retrospective data extraction from clinical and electronic patient records...
June 5, 2018: Journal of Allergy and Clinical Immunology in Practice
Kenneth L Hastings
Immunotoxicological research and testing have evolved from early studies of anaphylaxis to the robust and diverse field of immunotoxicology as we know it today. Early studies connecting immune dysfunction with exposure to exogenous agents focused on adverse reactions to immunogenic agents present in vaccines. Over time, work done by immunologists and pathologists leads to descriptions of characteristics of immunogenic agents as well as mechanisms by which anaphylaxis occurs and an understanding of the concept of immunosuppression...
2018: Methods in Molecular Biology
Natalia Blanca-Lopez, Maria L Somoza-Alvarez, Teresa Bellon, Gemma Amo, Gabriela Canto, Miguel Blanca
PURPOSE OF REVIEW: NSAIDs are the drugs most frequently involved in hypersensitivity reactions (HSR). These are frequently prescribed at all ages. HSR are of great concern and can affect people at any age. These drugs can induce reactions by stimulating the adaptive immune system (IgE or T cell), known as selective responders or more frequently by abnormalities in biochemical pathways related with prostaglandin metabolism. These are known as cross-intolerant. With some exceptions, skin testing and in-vitro studies are of little value in selective responders...
June 6, 2018: Current Opinion in Allergy and Clinical Immunology
Graham Roberts
No abstract text is available yet for this article.
June 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
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