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https://www.readbyqxmd.com/read/29454836/mechanism-for-initiation-of-food-allergy-dependence-on-skin-barrier-mutations-and-environmental-allergen-co-stimulation
#1
Matthew Walker, Jeremy Green, Ryan Ferrie, Ashley Queener, Mark H Kaplan, Joan M Cook-Mills
BACKGROUND: Mechanisms for the development of food allergy in neonates are unknown but are clearly linked in patient populations to a genetic predisposition towards skin barrier defects. Whether skin barrier defects functionally contribute to development of food allergy is unknown. OBJECTIVE: The purpose of the study was to determine whether skin barrier mutations, that are primarily heterozygous in patient populations, contribute to the development of food allergy...
February 15, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29453631/occupational-animal-allergy
#2
REVIEW
Gregg M Stave
PURPOSE OF REVIEW: This review explores animal allergen exposure in research laboratories and other work settings, focusing on causes and prevention. RECENT FINDINGS: (1) Consistent with the hygiene hypothesis, there is new evidence that early childhood exposure to pets produces changes in the gut microbiome that likely lead to a lower risk of allergy. (2) Anaphylaxis from laboratory animal bites occurs more frequently than suggested by prior literature. (3) Animal allergens represent an occupational hazard in a wide variety of work settings ranging from fields that work with animals to public settings like schools and public transportation where allergens are brought into or are present in the workplace...
February 16, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29451485/-the-roles-of-mast-cells-in-radiation-induced-damage-are-still-an-enigma
#3
Fabien Milliat, Agnès François
Mast cells are immune cells that mature within the host tissue. The acquired phenotype is dictated by the tissue microenvironment, giving rise to diverse tissue-dependent phenotypes and functions. The lack of cellular models reflecting phenotypes found in vivo and important differences between human and rodent mast cells are obstacles to the understanding of their exact role in several pathophysiological processes. Studies published over the past few years showed that mast cells' role lies far beyond their involvement in allergy and anaphylaxis...
February 2018: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/29449164/patients-taking-%C3%AE-blockers-do-not-require-increased-doses-of-epinephrine-for-anaphylaxis
#4
Jennifer L White, Katie C Greger, Sangil Lee, Robert J Kahoud, James T Li, Christine M Lohse, Ronna L Campbell
BACKGROUND: β-Blocker use has been associated with increased anaphylaxis severity. OBJECTIVE: We aimed to assess for an association between β-blocker use and requirement for more than 1 dose of epinephrine for anaphylaxis management. METHODS: We conducted a retrospective observational study of patients seen in our emergency department for anaphylaxis between April 2008 and January 2015. The primary outcome measure was the number of doses of epinephrine...
February 13, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29447722/no-276-management-of-group-b-streptococcal-bacteriuria-in-pregnancy
#5
Victoria M Allen, Mark H Yudin
OBJECTIVE: To provide information regarding the management of group B streptococcal (GBS) bacteriuria to midwives, nurses, and physicians who are providing obstetrical care. OUTCOMES: The outcomes considered were neonatal GBS disease, preterm birth, pyelonephritis, chorioamnionitis, and recurrence of GBS colonization. EVIDENCE: Medline, PubMed, and the Cochrane database were searched for articles published in English to December 2010 on the topic of GBS bacteriuria in pregnancy...
February 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29439456/epinephrine-in-anaphylaxis-preclinical-study-of-pharmacokinetics-after-sublingual-administration-of-taste-masked-tablets-for-potential-pediatric-use
#6
Ousama Rachid, Mutasem Rawas-Qalaji, Keith J Simons
Epinephrine is a life-saving treatment in anaphylaxis. In community settings, a first-aid dose of epinephrine is injected from an auto-injector (EAI). Needle phobia highly contributes to EAI underuse, leading to fatalities-especially in children. A novel rapidly-disintegrating sublingual tablet (RDST) of epinephrine was developed in our laboratory as a potential alternative dosage form. The aim of this study was to evaluate the sublingual bioavailability of epinephrine 30 mg as a potential pediatric dose incorporated in our novel taste-masked RDST in comparison with intramuscular (IM) epinephrine 0...
February 11, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29434182/corilagin-attenuates-allergy-and-anaphylactic-reaction-by-inhibiting-degranulation-of-mast-cells
#7
Jie Zhou, Ci'an Zhang, Yuanyuan Sun, Li Wang, Jian Zhang, Fulun Li, Weian Mao
BACKGROUND This study evaluated the anti-allergic activity of corilagin and also postulates the possible mechanism of its action. MATERIAL AND METHODS Corilagin was given orally at dose of 10, 20, and 40 mg/kg/day. All the animals (guinea pigs, rats, and mice) were sensitized for allergy such as eosinophilia and leukocytosis induced by milk; degranulation of mast cell by compound 48/80; and passive and active anaphylaxis. Moreover, the antagonistic effect was determined by estimating the effect of corilagin on contraction of guinea pig tracheal chain and ileum induced by Ach and histamine, respectively...
February 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29431885/important-and-specific-role-for-basophils-in-acute-allergic-reactions
#8
Peter Korošec, Bernhard F Gibbs, Matija Rijavec PhD, Adnan Custovic, Paul J Turner
IgE-mediated allergic reactions involve the activation of effector cells, predominantly through the high-affinity IgE receptor (FcεRI) on mast cells and basophils. Although the mast cell is considered the major effector cell during acute allergic reactions, more recent studies indicate a potentially important and specific role for basophils and their migration which occurs rapidly upon allergen challenge in humans undergoing anaphylaxis. We review the evidence for a role of basophils in contributing to clinical symptoms of anaphylaxis, and discuss the possibility that basophil trafficking during anaphylaxis might be a pathogenic (to target organs) or protective (preventing degranulation in circulation) response...
February 12, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29431216/mast-cell-neural-interactions-contribute-to-pain-and-itch
#9
REVIEW
Kalpna Gupta, Ilkka T Harvima
Mast cells are best recognized for their role in allergy and anaphylaxis, but increasing evidence supports their role in neurogenic inflammation leading to pain and itch. Mast cells act as a "power house" by releasing algogenic and pruritogenic mediators, which initiate a reciprocal communication with specific nociceptors on sensory nerve fibers. Consequently, nerve fibers release inflammatory and vasoactive neuropeptides, which in turn activate mast cells in a feedback mechanism, thus promoting a vicious cycle of mast cell and nociceptor activation leading to neurogenic inflammation and pain/pruritus...
March 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29431209/biomarkers-for-evaluation-of-mast-cell-and-basophil-activation
#10
REVIEW
Kenji Kabashima, Chisa Nakashima, Yumi Nonomura, Atsushi Otsuka, Chiara Cardamone, Roberta Parente, Giulia De Feo, Massimo Triggiani
Mast cells and basophils play a pathogenetic role in allergic, inflammatory, and autoimmune disorders. These cells have different development, anatomical location and life span but share many similarities in mechanisms of activation and type of mediators. Mediators secreted by mast cells and basophils correlate with clinical severity in asthma, chronic urticaria, anaphylaxis, and other diseases. Therefore, effective biomarkers to measure mast cell and basophil activation in vivo could potentially have high diagnostic and prognostic values...
March 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29424676/a-multicenter-randomized-double-blind-dose-finding-study-of-condoliase-in-patients-with-lumbar-disc-herniation
#11
Yukihiro Matsuyama, Kazuhiro Chiba, Hisashi Iwata, Takayuki Seo, Yoshiaki Toyama
OBJECTIVE Chemonucleolysis with condoliase has the potential to be a new, less invasive therapeutic option for patients with lumbar disc herniation (LDH). The aim of the present study was to determine the most suitable therapeutic dose of condoliase. METHODS Patients between 20 and 70 years of age with unilateral leg pain, positive findings on the straight leg raise test, and LDH were recruited. All eligible patients were randomly assigned to receive condoliase (1.25, 2.5, or 5 U) or placebo. The primary end point was a change in the worst leg pain from preadministration (baseline) to week 13...
February 9, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29423371/identification-of-a-thermal-stable-allergen-in-yam-dioscorea-opposita-to-cause-anaphylaxis
#12
Ying-Yang Xu, Jia Yin
Yam (Dioscorea opposita) is commonly consumed in East Asia, but allergic reaction to this plant food is rare. To date, there is no report of anaphylactic reaction after ingestion of cooked yam. We described 3 cases with anaphylaxis after eating boiled yam and 1 present with oral allergy syndrome as well. Basophil activation test in patients showed positive reactivity to boiled yam extract. In immunoblotting, a 30-kDa protein was recognized by all patients' sera and a 17-kDa band was detected by 1 patient. N-terminal amino acid revealed the 30-kDa IgE reacted band was DB3S, dioscorin in Dioscorea tuber...
January 2018: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29422823/anaphylaxis-in-poland-the-epidemiology-and-direct-costs
#13
Karina Jahnz-Rozyk, Filip Raciborski, Andrzej M Śliwczyński, Anna Kłak, Jarosław Pinkas
Introduction: Epidemiological data on anaphylaxis have been underestimated both in Poland and worldwide. Aim: To evaluate the prevalence of anaphylaxis in Poland, including a classification by gender, age and residential region. Material and methods: The data used in the analysis were derived from two sources, the National Health Fund records of healthcare services for 2008-2015 (official statistics) and a questionnaire-based survey conducted in 2015 on a sample of 305 allergists practicing in different regions of Poland...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29421275/reprograming-immunity-to-food-allergens
#14
Ashley L St John, Gladys W X Ang, Abhay P S Rathore, Soman N Abraham
A novel immune-modulatory therapy utilizing targeted delivery of cytokines to draining lymph nodes effectively reprograms Th2 allergic responses towards a Th1 and tolerogenic profile, resulting in protection from peanut antigen-induced anaphylaxis.
February 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29417614/comparative-safety-of-intravenous-ferumoxytol-vs-ferric-carboxymaltose-in-iron-deficiency-anemia-a-randomized-trial
#15
N Franklin Adkinson, William E Strauss, Iain C Macdougall, Kristine E Bernard, Michael Auerbach, Robert F Kaper, Glenn M Chertow, Julie S Krop
Few trials have examined rates of hypersensitivity reactions (HSRs) with intravenous iron formulations used to treat iron deficiency anemia. This randomized, multicenter, double-blind clinical trial compared the safety and efficacy of ferumoxytol versus ferric carboxymaltose (FCM), focusing on rates of HSRs and hypotension as the primary end point. Patients with iron deficiency anemia of any etiology in whom oral iron was unsatisfactory or intolerable received ferumoxytol (n = 997) or FCM (n = 1000) intravenously over ≥15 minutes on days 1 and 8 or 9 for total respective doses of 1...
February 8, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29415679/downstream-consequences-of-diagnostic-error-in-pediatric-anaphylaxis
#16
H Thomson, R Seith, S Craig
BACKGROUND: Pediatric anaphylaxis is commonly misdiagnosed in the Emergency Department (ED). We aimed to determine the impact of inaccurate diagnosis on the management and follow-up of pediatric anaphylaxis presenting to the ED. METHODS: Retrospective chart review of ED management of children aged 0-18 years with allergic presentations to three EDs in Melbourne, Australia in 2014. Cases were included if an ED diagnosis of anaphylaxis was recorded, or the presentation met international consensus criteria for anaphylaxis...
February 7, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29413255/vaccine-associated-hypersensitivity
#17
REVIEW
Michael M McNeil, Frank DeStefano
Vaccine-associated hypersensitivity reactions are not infrequent; however, serious acute-onset, presumably IgE-mediated or IgG and complement-mediated anaphylactic or serious delayed-onset T cell-mediated systemic reactions are considered extremely rare. Hypersensitivity can occur because of either the active vaccine component (antigen) or one of the other components. Postvaccination acute-onset hypersensitivity reactions include self-limited localized adverse events and, rarely, systemic reactions ranging from urticaria/angioedema to full-blown anaphylaxis with multisystem involvement...
February 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29411737/chlorhexidine-induced-anaphylaxis-occurring-in-the-workplace-in-a-health-care-worker-case-report-and-review-of-the-literature
#18
Alessandra Toletone, Guglielmo Dini, Emanuela Massa, Nicola Luigi Bragazzi, Patrizia Pignatti, Susanna Voltolini, Paolo Durando
BACKGROUND: Chlorhexidine has been widely used in the occupational field as an effective antiseptic and disinfectant, especially in the health-care services. Several cases of allergic reactions to chlorhexidine have been reported, both in the general population and in workers. OBJECTIVES: To describe a case of occupational chlorhexidine-induced severe anaphylaxis that occurred in the workplace in a health-care worker (HCW) and to update the literature on chlorhexidine as a possible occupational allergen...
February 1, 2018: La Medicina del Lavoro
https://www.readbyqxmd.com/read/29411561/a-case-of-intraoperative-anaphylaxis-caused-by-bovine-derived-thrombin
#19
Hye Jung Park, Kyung Soo Suk, Jung Won Park
Intraoperative bovine-derived topical thrombin is still widely used for hemostasis during surgery. A 38-year-old woman with chronic spontaneous urticaria was referred to the orthopedic surgery department for herniated disk and myelopathy. During the first stage of operation, bovine-derived thrombin powder soaked in Gelfoam was used as a hemostatic aid. After 30 minutes, the patient developed anaphylactic shock with systemic skin rash and angioedema. Repeated intravenous bolus and infusion of vasopressor were carried out, and her blood pressure normalized...
March 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29411554/are-registration-of-disease-codes-for-adult-anaphylaxis-accurate-in-the-emergency-department
#20
Byungho Choi, Sun Hyu Kim, Hyeji Lee
PURPOSE: There has been active research on anaphylaxis, but many study subjects are limited to patients registered with anaphylaxis codes. However, anaphylaxis codes tend to be underused. The aim of this study was to investigate the accuracy of anaphylaxis code registration and the clinical characteristics of accurate and inaccurate anaphylaxis registration in anaphylactic patients. METHODS: This retrospective study evaluated the medical records of adult patients who visited the university hospital emergency department between 2012 and 2016...
March 2018: Allergy, Asthma & Immunology Research
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