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Anaphylaxis

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https://www.readbyqxmd.com/read/29027242/optimal-dose-and-duration-of-amoxicillin-plus-metronidazole-as-an-adjunct-to-non-surgical-periodontal-therapy-a-systematic-review-and-meta-analysis-of-randomized-placebo-controlled-trials
#1
REVIEW
Kelly McGowan, Troy McGowan, Saso Ivanovski
AIM: This systematic review aimed to determine the optimum dose and duration of amoxicillin-plus-metronidazole prescribed as an adjunct to non-surgical treatment of periodontitis. METHODS: Electronic searching identified 376 records, of which 18 were eligible blinded, randomized placebo-controlled trials. The primary outcomes assessed were periodontal pocket depth and clinical attachment level at 3-months, and secondary outcomes were adverse events and compliance...
October 13, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29021884/life-threatening-chlorhexidine-anaphylaxis-a-case-report
#2
R Y Kow, C L Low, J K Ruben, M Z Zaharul-Azri, M S Ng
Chlorhexidine is a common antiseptic and disinfectant used in the medical field. Allergy to chlorhexidine has been reported in the literature but life-threatening anaphylactic shock is rare. We present a case of severe anaphylactic shock due to chlorhexidine occurring during surgery. Literatures suggest that profound anaphylactic shock to chlorhexidine is commonly preceded by milder, non-specific reactions. These mild symptoms are often dismissed by both the patient and physicians alike. Direct questioning of these symptoms is necessary as a part of the pre-operative assessment and the patient should be referred for further immunology testing if indicated...
July 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29018449/mechanisms-cofactors-and-augmenting-factors-involved-in-anaphylaxis
#3
REVIEW
Rosa Muñoz-Cano, Mariona Pascal, Giovanna Araujo, M J Goikoetxea, Antonio L Valero, Cesar Picado, Joan Bartra
Anaphylaxis is an acute and life-threatening systemic reaction. Many triggers have been described, including food, drug, and hymenoptera allergens, which are the most frequently involved. The mechanisms described in anaphylactic reactions are complex and implicate a diversity of pathways. Some of these mechanisms may be key to the development of the anaphylactic reaction, while others may only modify its severity. Although specific IgE, mast cells, and basophils are considered the principal players in anaphylaxis, alternative mechanisms have been proposed in non-IgE anaphylactic reactions...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29017902/small-percentage-of-anaphylactic-reactions-treated-with-epinephrine-during-food-challenges-in-dutch-children
#4
Johanna P M van der Valk, Irene Berends, Roy Gerth van Wijk, Nicolette J T Arends, Maurits S van Maaren, Hans de Groot, Harry J Wichers, Joyce A M Emons, Anthony E J Dubois, Nicolette W de Jong
BACKGROUND: Severe allergic reactions, including anaphylaxis, occur during oral food challenges (OFCs) and the first-line treatment of anaphylaxis is epinephrine. OBJECTIVE: To evaluate the percentage of anaphylactic reactions treated with epinephrine during OFCs and to identify associated factors for the administration of epinephrine. METHODS: Children who underwent an OFC with peanut, hazelnut, cow's milk, hen's egg, or cashew nut from 2005 through 2015 in the Netherlands were evaluated...
October 7, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29017833/cross-reactivity-in-%C3%AE-lactam-allergy
#5
Robert J Zagursky, Michael E Pichichero
β-Lactam drugs (penicillins, amoxicillin, and cephalosporins) account for 42.6% of all severe drug-induced anaphylaxis. In this review, we focus on clinically significant immunologic cross-reactivity in patients with confirmed penicillin allergy to cephalosporins, and the structural involvement of the R1 and R2 chemical side chains of the cephalosporins causing IgE-mediated cross-reactivity with penicillin and other cephalosporins. Skin tests predict IgE-mediated reactions and showed cross-reactivity between penicillins and early generation cephalosporins that shared side chains, but confirmatory challenge data are lacking...
October 7, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29017820/possible-utility-of-the-basophil-activation-test-for-the-analysis-of-mechanisms-involved-in-allergic-transfusion-reactions
#6
REVIEW
Fumiya Hirayama, Kazuta Yasui, Nobuki Matsuyama, Ikue Okamura-Shiki
Allergic transfusion reactions (ATRs) are the most common adverse reactions occurring during transfusion of blood components. Although most reactions are mild and involve cutaneous manifestations, severe ATRs including life-threatening anaphylaxis may also occur. The mechanisms of ATRs are largely unknown because they have not been well studied. One of the reasons for this may be the absence of a standard assay system for investigating these processes. Basophils and/or mast cells are key effector cells in immediate-type allergic reactions...
September 19, 2017: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29016916/sensitization-to-cow-s-milk-protein-in-a-dairy-worker
#7
B Quirantes Sierra, A Lara Jiménez, M Skodova
Background: Repeated skin exposure and inhalation of milk proteins may lead to IgE-mediated sensitization, normally manifested at the site of contact. Although this is a phenomenon predominantly found in children, it has also been observed in adults. Aims: To describe a case of a worker who, after being exposed to milk proteins for many years, eventually experienced episodes of anaphylaxis. Case report: A 62-year-old worker experienced severe episodes of anaphylaxis following the intake of dairy products...
September 2, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29016518/gastric-drainage-in-the-treatment-of-near-fatal-food-induced-anaphylaxis
#8
Isaac Lazar, Yuval Cavari, Aviva Levitas, Amarilia B Mandolla, Arnon Broides
Anaphylaxis should be treated with early administration of intramuscular Adrenalin; however, fatalities may still occur even with this therapy. We report a patient with near-fatal anaphylaxis due to milk whose symptoms persisted and were resistant to any therapeutic attempt; however, the patient had a prompt resolution of the anaphylaxis shortly after a nasogastric tube placement with gastric drainage, suggesting that this procedure ended the ongoing absorption of additional allergen from the gastrointestinal tract...
October 9, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28984794/the-use-of-povidone-iodine-in-ophthalmology
#9
Andrzej Grzybowski, Piotr Kanclerz, William G Myers
PURPOSE OF REVIEW: Povidone-iodine (PVI) is a disinfectant and antiseptic agent used for preoperative preparation of the skin and mucous membranes, as well as for the treatment of contaminated wounds. Currently regimens for prophylaxis against postsurgical endophthalmitis are being modified, including a total withdrawal of antibiotics in intravitreal injections. The aim of this study was to evaluate the use of PVI in ophthalmology. RECENT FINDINGS: As a result of its broad spectrum of microbicidal activity, PVI is routinely used in ophthalmic surgery...
October 3, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28978894/dynamic-regulation-of-vascular-permeability-by-vascular-endothelial-cadherin-mediated-endothelial-cell-cell-junctions
#10
Seung-Sik Rho, Koji Ando, Shigetomo Fukuhara
Endothelial cells lining blood vessels regulate vascular barrier function, which controls the passage of plasma proteins and circulating cells across the endothelium. In most normal adult tissues, endothelial cells preserve basal vascular permeability at a low level, while they increase permeability in response to inflammation. Therefore, vascular permeability is tightly controlled by a number of extracellular stimuli and mediators to maintain tissue homeostasis. Accordingly, impaired regulation of endothelial permeability causes various diseases, including chronic inflammation, asthma, edema, sepsis, acute respiratory distress syndrome, anaphylaxis, tumor angiogenesis, and diabetic retinopathy...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28976750/inhibition-of-mast-cell-mediated-allergic-responses-by-arctii-fructus-extracts-and-its-main-compound-arctigenin
#11
Ji-Ye Kee, Seung-Heon Hong
The Arctium lappa (Arctii Fructus) seed and its major active compound, arctigenin (ARC), are known to have anti-cancer, anti-obesity, anti-osteoporosis, and anti-inflammatory activities. However, the effect of Arctii Fructus and ARC on mast cell-mediated allergic inflammation and the associated mechanism have not been elucidated. Therefore, we attempted to investigate the anti-allergic activity of Arctii Fructus and ARC on mast cells and experimental mouse models. Arctii Fructus water (AFW) or ethanol extract (AFE) and ARC reduced the production of histamine and pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, IL-8, and TNF-α in mast cells...
October 4, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28972639/kanelbullar-utl%C3%A3-ste-anafylaktisk-reaktion-genesen-kan-vara-veteberoende-anstr%C3%A3-ngningsutl%C3%A3-st-anafylaxi
#12
Adriana-Maria Hiller, Stefan Willers
Cinnamon rolls triggered anaphylactic reaction. The genesis could be wheat-dependent exercise-induced anaphylaxis Two case reports from our Department of Allergology illustrate the wheat-dependent exercise-induced anaphylaxis (WDEIA), which is a relatively rare, yet potentially fatal form of food allergy. Wheat (Triticum aestivum) is the most commonly grown crop world-wide, and some individuals cannot tolerate it due to wheat hypersensitivity. The most dangerous reaction is the anaphylaxis due to harmful immune responses to various parts of the wheat proteins...
October 2, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28966616/factor-xii-driven-inflammatory-reactions-with-implications-for-anaphylaxis
#13
REVIEW
Lysann Bender, Henri Weidmann, Stefan Rose-John, Thomas Renné, Andy T Long
Anaphylaxis is a life-threatening allergic reaction. It is triggered by the release of pro-inflammatory cytokines and mediators from mast cells and basophils in response to immunologic or non-immunologic mechanisms. Mediators that are released upon mast cell activation include the highly sulfated polysaccharide and inorganic polymer heparin and polyphosphate (polyP), respectively. Heparin and polyP supply a negative surface for factor XII (FXII) activation, a serine protease that drives contact system-mediated coagulation and inflammation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28965967/evaluation-of-nanoparticles-as-oral-vehicles-for-immunotherapy-against-experimental-peanut-allergy
#14
Ana Brotons-Canto, Carlos Gamazo, Nekane Martín-Arbella, Muthanna Abdulkarim, Jose Matías, Mark Gumbleton, Juan M Irache
The aim of this work was to evaluate the potential application of an original oral immunotherapy, based on the use of nanoparticles, against an experimentally induced peanut allergy. In this context, a roasted peanut extract, containing the main allergenic proteins, were encapsulated into poly(anhydride) nanoparticles. The resulting devices (PE-NP) displayed a mean size of about 150nm and a significantly lower surface hydrophobicity than empty nanoparticles (NP). This low hydrophobicity correlated well with a higher in vitro diffusion in pig intestinal mucus than NP and an important in vivo capability to reach the intestinal epithelium and Peyer's patches...
September 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28965631/drug-induced-anaphylaxis
#15
REVIEW
Marcelo Vivolo Aun, Jorge Kalil, Pedro Giavina-Bianchi
Drugs are among the main triggers of anaphylaxis, but identification of the culprit drug is frequently difficult. To confirm diagnosis of the causative agent, medical records and clinical history are fundamental. There are a few in vitro tests available in clinical practice, such as serum-specific IgE and basophil activation test. Skin tests are often useful for the diagnosis, although drug challenge is indicated in patients with inconclusive clinical history or to provide safe alternatives. Treatment of anaphylaxis is standard and intramuscular epinephrine is the main agent to prevent morbidity and mortality...
November 2017: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/28964543/didox-3-4-dihydroxybenzohydroxamic-acid-suppresses-ige-mediated-mast-cell-activation-through-attenuation-of-nf%C3%AE%C2%BAb-and-ap-1-transcription
#16
Jamie Josephine Avila McLeod, Heather L Caslin, Andrew J Spence, Elizabeth M Kolawole, Amina Abdul Qayum, Anuya Paranjape, Marcela Taruselli, Tamara T Haque, Kasalina N Kiwanuka, Howard L Elford, John J Ryan
Mast cell activation via the high-affinity IgE receptor (FcεRI) elicits production of inflammatory mediators central to allergic disease. As a synthetic antioxidant and a potent ribonucleotide reductase (RNR) inhibitor, Didox (3,4-dihyroxybenzohydroxamic acid) has been tested in clinical trials for cancer and is an attractive therapeutic for inflammatory disease. We found that Didox treatment of mouse bone marrow-derived mast cells (BMMC) reduced IgE-stimulated degranulation and cytokine production, including IL-6, IL-13, TNF and MIP-1a (CCL3)...
September 21, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28964465/gadolinium-based-contrast-agents-associated-adverse-reactions
#17
REVIEW
Miguel Ramalho, Joana Ramalho
Gadolinium-based contrast agents have been considered extremely safe drugs with a low incidence of acute adverse reactions. Most of the reactions are mild and physiologic. However, despite being extremely rare, acute severe adverse reactions, including anaphylaxis, may occur. In this article adverse reactions are discussed with regard to their classification, pathophysiology, symptoms, and risk factors.
November 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/28959670/is-andrographis-paniculata-extract-and-andrographolide-anaphylactic
#18
Edwin Jothie Richard, Sasikumar Murugan, Bharathi Bethapudi, Ramanaiah Illuri, Deepak Mundkinajeddu, Chandrasekaran Chinampudur Velusami
Andrographis paniculata, "King of bitters" is a popularly known medicinal plant extensively used in many parts of the world for treatment of various diseases. Since recent past, anaphylactic/allergic type adverse events were reported upon A. paniculata usage, the study aimed to evaluate the anaphylactic and anaphylactoid potential of A. paniculata extract and andrographolide (a major phytoactive of A. paniculata). The anaphylactic potential was evaluated using active systemic anaphylaxis (ASA) assay in guinea pigs...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28958738/the-cost-of-penicillin-allergy-evaluation
#19
Kimberly G Blumenthal, Yu Li, Aleena Banerji, Brian J Yun, Aidan A Long, Rochelle P Walensky
BACKGROUND: Unverified penicillin allergy leads to adverse downstream clinical and economic sequelae. Penicillin allergy evaluation can be used to identify true, IgE-mediated allergy. OBJECTIVE: To estimate the cost of penicillin allergy evaluation using time-driven activity-based costing (TDABC). METHODS: We implemented TDABC throughout the care pathway for 30 outpatients presenting for penicillin allergy evaluation. The base-case evaluation included penicillin skin testing and a 1-step amoxicillin drug challenge, performed by an allergist...
September 22, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28958375/risk-factors-for-severe-anaphylaxis-in-the-united-states
#20
Megan S Motosue, M Fernanda Bellolio, Holly K Van Houten, Nilay D Shah, Ronna L Campbell
BACKGROUND: Anaphylaxis is an acute systemic allergic reaction and may be life-threatening. OBJECTIVE: To assess risk factors associated with severe and near-fatal anaphylaxis in a large observational cohort study. METHODS: We analyzed administrative claims data from Medicare Advantage and privately insured enrollees in the United States from 2005 to 2014. Severe anaphylaxis was defined as anaphylaxis resulting in hospital or intensive care unit (ICU) admission, requiring endotracheal intubation, or meeting criteria for near-fatal anaphylaxis...
October 2017: Annals of Allergy, Asthma & Immunology
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