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https://www.readbyqxmd.com/read/28215132/physiological-antecedents-and-ward-clinician-responses-before-medical-emergency-team-activation
#1
Stephanie K Sprogis, Judy Currey, Julie Considine, Ian Baldwin, Daryl Jones
OBJECTIVES: To investigate the frequency, characteristics and timing of objectively measured clinical instability in adult ward patients in the 24 hours preceding activation of the medical emergency team (MET). We also examined ward clinician responses to documented clinical instability. DESIGN, SETTING AND PARTICIPANTS: A descriptive, exploratory design with a retrospective medical record audit. We descriptively analysed data from 200 ward patients reviewed by the MET at a tertiary teaching hospital in Melbourne, Australia, during 2014...
March 2017: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/28207890/mucosal-stromal-fibroblasts-markedly-enhance-hiv-infection-of-cd4-t-cells
#2
Jason A Neidleman, Joseph C Chen, Nargis Kohgadai, Janis A Müller, Anders Laustsen, Karthiga Thavachelvam, Karen S Jang, Christina M Stürzel, Jennifer J Jones, Christina Ochsenbauer, Avantika Chitre, Ma Somsouk, Maurice M Garcia, James F Smith, Ruth M Greenblatt, Jan Münch, Martin R Jakobsen, Linda C Giudice, Warner C Greene, Nadia R Roan
Understanding early events of HIV transmission within mucosal tissues is vital for developing effective prevention strategies. Here, we report that primary stromal fibroblasts isolated from endometrium, cervix, foreskin, male urethra, and intestines significantly increase HIV infection of CD4+ T cells-by up to 37-fold for R5-tropic HIV and 100-fold for X4-tropic HIV-without themselves becoming infected. Fibroblasts were more efficient than dendritic cells at trans-infection and mediate this response in the absence of the DC-SIGN and Siglec-1 receptors...
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28192675/sentinels-of-breach
#3
Andrew J Hampton, Valerie L Shalin
Objective This paper identifies general properties of language style in social media to help identify areas of need in disasters. Background In the search for metrics of need in social media data, much of the existing literature ignores processes of language usage. Psychological concepts, such as narrative breach, Gricean maxims, and lexical marking in cognition, may assist the recovery of disaster-relevant metrics from altered patterns of word prevalence. Method We analyzed several hundred thousand location-specific microblogs from Twitter for Hurricane Sandy, Oklahoma tornadoes, and the Boston Marathon bombing along with a fantasy football control corpus, examining the relative frequency of words in 36 antonym pairs...
February 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28192531/multi-layered-control-of-galectin-8-mediated-autophagy-during-adenovirus-cell-entry-through-a-conserved-ppxy-motif-in-the-viral-capsid
#4
Charlotte Montespan, Shauna A Marvin, Sisley Austin, Andrew M Burrage, Benoit Roger, Fabienne Rayne, Muriel Faure, Edward M Campell, Carola Schneider, Rudolph Reimer, Kay Grünewald, Christopher M Wiethoff, Harald Wodrich
Cells employ active measures to restrict infection by pathogens, even prior to responses from the innate and humoral immune defenses. In this context selective autophagy is activated upon pathogen induced membrane rupture to sequester and deliver membrane fragments and their pathogen contents for lysosomal degradation. Adenoviruses, which breach the endosome upon entry, escape this fate by penetrating into the cytosol prior to autophagosome sequestration of the ruptured endosome. We show that virus induced membrane damage is recognized through Galectin-8 and sequesters the autophagy receptors NDP52 and p62...
February 13, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28187060/risk-factors-in-children-older-than-5-years-with-pneumococcal-meningitis-data-from-a-national-network
#5
Fanny Hénaff, Corinne Levy, Robert Cohen, Capucine Picard, Emmanuelle Varon, Christèle Gras Le Guen, Elise Launay
INTRODUCTION: The occurrence of meningitis in children > 5 years old may be associated with specific predisposing factors that can be anatomic, such as cerebrospinal fluid (CSF) fistula or breach, or related to genetic susceptibility or N inborn or acquired immunologic defect. This study aimed to assess the anatomical and immunologic risk factors in children > 5 years old with pneumococcal meningitis and prospectively enrolled in the French national meningitis network. METHODS: We analyzed all data for children 5 to 15 years old with a diagnosis of pneumococcal meningitis between 2001 and 2013...
December 13, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28166870/causes-consequences-and-countermeasures-to-driver-fatigue-in-the-rail-industry-the-train-driver-perspective
#6
A J Filtness, A Naweed
Fatigue is an important workplace risk management issue. Within the rail industry, the passing of a stop signal (signal passed at danger; SPAD) is considered to be one of the most major safety breaches which can occur. Train drivers are very aware of the negative consequences associated with a SPAD. Therefore, SPADs provide a practical and applied safety relevant context within which to structure a discussion on fatigue. Focus groups discussing contributing factors to SPADs were undertaken at eight passenger rail organisations across Australia and New Zealand (n = 28 drivers)...
April 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28151989/cd8-t-cells-protect-adult-naive-mice-from-jev-induced-morbidity-via-lytic-function
#7
Nidhi Jain, Neelam Oswal, Amanpreet Singh Chawla, Tanvi Agrawal, Moanaro Biswas, Sudhanshu Vrati, Satyajit Rath, Anna George, Vineeta Bal, Guruprasad R Medigeshi
Following Japanese encephalitis virus (JEV) infection neutralizing antibodies are shown to provide protection in a significant proportion of cases, but not all, suggesting additional components of immune system might also contribute to elicit protective immune response. Here we have characterized the role of T cells in offering protection in adult mice infected with JEV. Mice lacking α/β-T cells (TCRβ-null) are highly susceptible and die over 10-18 day period as compared to the wild-type (WT) mice which are resistant...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28122155/support-workers-in-community-mental-health-teams-for-older-people-roles-boundaries-supervision-and-training
#8
Mark Wilberforce, Michele Abendstern, Sue Tucker, Saima Ahmed, Rowan Jasper, David Challis
AIMS: To explore the support worker functions in community mental health teams for older adults in relation to roles, boundaries, supervision and training. BACKGROUND: Support workers in community mental health teams provide important help to older people with complex mental and physical health needs in their own homes. Their numbers have grown substantially in recent years, but without professional registration there is concern that boundaries with qualified practitioners are insufficiently clear and that they do not receive the support they require...
January 25, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28121471/confidentiality-in-biobanking-research-a-comparison-of-donor-and-nondonor-families-understanding-of-risks
#9
Laura A Siminoff, Maureen Wilson-Genderson, Maghboeba Mosavel, Laura Barker, Jennifer Trgina, Heather M Traino
AIMS: Confidentiality of personal identifiers potentially linking the genetic results from biobanking participants back to the donor and donor relatives is a concern. The risks associated with a breach of confidentiality should be ascertained when biobanks collect samples requiring the consent of a family decision maker (FDM) from deceased organ and tissue donors. This article explores FDM knowledge and opinions regarding risks associated with participation in biobanking research in the context of the Genotype-Tissue Expression (GTEx) Project...
January 25, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28104498/laparoscopic-myomectomy-a-single-centre-retrospective-review-of-514-patients
#10
Elisabeth Mary Ruth Bean, Alfred Cutner, Tom Holland, Arvind Vashisht, Davor Jurkovic, Ertan Saridogan
STUDY OBJECTIVE: To review surgical outcomes and histopathological findings following laparoscopic myomectomy by a team at a university teaching hospital. DESIGN: This was a retrospective review of consecutive cases of laparoscopic myomectomy carried out by members of our minimal access surgery team between January 2004 and December 2015. DESIGN CLASSIFICATION: Canadian Task Force Classification II-3 SETTING: University Teaching Hospital PATIENTS: Women undergoing laparoscopic myomectomy INTERVENTIONS: Laparoscopic myomectomy MEASUREMENTS AND MAIN RESULTS: We collected women's demographic data, clinical histories and surgical outcomes, including complication rates and the incidence of undiagnosed uterine malignancy...
January 16, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28067833/contribution-of-the-rgfd-quorum-sensing-peptide-to-rgf-regulation-and-host-cell-association-in-group-b-streptococcus
#11
Robert E Parker, David Knupp, Rim Al Safadi, Agnѐs Rosenau, Shannon D Manning
Streptococcus agalactiae (group B Streptococcus; GBS) is a common inhabitant of the genitourinary and/or gastrointestinal tract in up to 40% of healthy adults; however, this opportunistic pathogen is able to breach restrictive host barriers to cause disease and persist in harsh and changing conditions. This study sought to identify a role for quorum sensing, a form of cell to cell communication, in the regulation of the fibrinogen-binding (rgfBDAC) two-component system and the ability to associate with decidualized endometrial cells in vitro...
January 6, 2017: Genes
https://www.readbyqxmd.com/read/28057474/hiv-1-tat-disrupts-blood-brain-barrier-integrity-and-increases-phagocytic-perivascular-macrophages-and-microglia-in-the-dorsal-striatum-of-transgenic-mice
#12
Crystal R Leibrand, Jason J Paris, M Said Ghandour, Pamela E Knapp, Woong-Ki Kim, Kurt F Hauser, MaryPeace McRae
HIV-1 infection results in blood-brain barrier (BBB) disruption, which acts as a rate-limiting step for HIV-1 entry into the CNS and for subsequent neuroinflammatory/neurotoxic actions. One mechanism by which HIV may destabilize the BBB involves actions of the HIV-1 regulatory protein, trans-activator of transcription (Tat). We utilized a conditional, Tat-expressing transgenic murine model to examine the influence of Tat1-86 expression on BBB integrity and to assess the relative numbers of phagocytic perivascular macrophages and microglia within the CNS in vivo...
February 15, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28052843/trust-me-i-m-a-doctor-examining-changes-in-how-privacy-concerns-affect-patient-withholding-behavior
#13
Daniel M Walker, Tyler Johnson, Eric W Ford, Timothy R Huerta
BACKGROUND: As electronic health records (EHRs) become ubiquitous in the health care industry, privacy breaches are increasing and being made public. These breaches may make consumers wary of the technology, undermining its potential to improve care coordination and research. OBJECTIVE: Given the developing concerns around privacy of personal health information stored in digital format, it is important for providers to understand how views on privacy and security may be associated with patient disclosure of health information...
January 4, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28047881/we-ab-bra-07-operating-room-quality-assurance-orqa-for-spine-surgery-using-known-component-3d-2d-image-registration
#14
A Uneri, T De Silva, J Goerres, M Jacobson, M Ketcha, S Reaungamornrat, G Kleinszig, S Vogt, A Khanna, J Wolinsky, J Siewerdsen
PURPOSE: Intraoperative x-ray radiography/fluoroscopy is commonly used to qualitatively assess delivery of surgical devices (e.g., spine pedicle screws) but can fail to reliably detect suboptimal placement (e.g., breach of adjacent critical structures). We present a method wherein prior knowledge of the patient and surgical components is leveraged to match preoperative CT and intraoperative radiographs for quantitative assessment of 3D pose. The method presents a new means of operating room quantitative quality assurance (ORQA) that could improve quality and safety, and reduce the frequency of revision surgeries...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045921/peripheral-venous-catheter-related-adverse-events-evaluation-from-a-multicentre-epidemiological-study-in-france-the-catheval-project
#15
Katiuska Miliani, Raphaël Taravella, Denis Thillard, Valérie Chauvin, Emmanuelle Martin, Stéphanie Edouard, Pascal Astagneau
INTRODUCTION: Peripheral venous catheters (PVC) are medical devices most frequently used during hospital care. Although the frequency of specific PVC-related adverse events (PVCAEs) has been reported, the global risk related to the insertion of this device is poorly estimated. The aim of this study is to determine the incidence of PVCAEs during the indwell time, after catheter removal, and to identify practice-mirroring risk factors. METHODS: A prospective observational study was conducted as a part of a research project, called CATHEVAL, in one surgery ward and four medicine wards from three public general tertiary care hospitals in Northern France that were invited to participate between June-2013 and June-2014...
2017: PloS One
https://www.readbyqxmd.com/read/28045712/exploring-the-experiences-of-women-and-health-care-workers-in-the-context-of-pmtct-option-b-plus-in-malawi
#16
Fabian Cataldo, Levison Chiwaula, Misheck Nkhata, Monique van Lettow, Florence Kasende, Nora E Rosenberg, Hannock Tweya, Veena Sampathkumar, Mina Hosseinipour, Erik Schouten, Atupele Kapito-Tembo, Michael Eliya, Frank Chimbwandira, Sam Phiri
INTRODUCTION: Malawi has embarked on a 'test-and-treat' approach to prevent mother-to-child transmission of HIV (PMTCT), known as 'Option B+', offering all HIV-infected pregnant and breastfeeding women lifelong antiretroviral treatment (ART) regardless of CD4-count or clinical stage. We conducted a cross-sectional qualitative study to explore early experiences surrounding 'Option B+' for patients and health care workers (HCWs) in Malawi. METHODS: Study participants were purposively selected across six health facilities in three regional health zones in Malawi...
December 9, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28008676/direct-mapping-of-melanoma-cell-endothelial-cell-interactions
#17
Béla Varga, Csilla Fazakas, Judit Molnár, Imola Wilhelm, Réka A Domokos, István A Krizbai, Zsolt Szegletes, György Váró, Attila G Végh
The most life-threatening aspect of cancer is metastasis; cancer patient mortality is mainly due to metastasis. Among all metastases, presence of brain metastasis is one with the poorest prognosis; the median survival time can be counted in months. Therefore, prevention or decreasing their incidence would be highly desired both by patients and physicians. Metastatic cells invading the brain must breach the cerebral vasculature, primarily the blood-brain barrier. The key step in this process is the establishment of firm adhesion between the cancer cell and the cerebral endothelial layer...
December 23, 2016: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/27998049/long-term-results-of-outside-instructions-for-use-evar
#18
José Oliveira-Pinto, Nelson Oliveira, Frederico Bastos-Gonçalves, Sanne Hoeks, Marie J VAN Rijn, Sander Ten Raa, Armando Mansilha, Hence J Verhagen
BACKGROUNG: Endovascular aneurysm repair (EVAR) has progressively expanded to more complex anatomies, frequently outside manufacturer's instructions for use (IFU). However, the long term results of off-label use of EVAR remains largely undocumented. The aim of this paper is to examine the long term results of outside IFU EVAR. METHODS: English literature was searched to identify publications on long term results for outside IFU EVAR. A follow-up extending for at least 5 years was the minimum required as inclusion criteria...
December 19, 2016: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27935447/lateral-mass-screw-stimulation-thresholds-in-posterior-cervical-instrumentation-surgery-a-predictor-of-medial-deviation
#19
Bayard Wilson, Erik Curtis, Brian Hirshman, Ahmet Oygar, Karen Chen, Brandon C Gabel, Florin Vaida, David W Allison, Joseph D Ciacci
OBJECTIVE Normative data exists for stimulus-evoked pedicle screw electromyography (EMG) current thresholds in the lumbar spine, and is routinely referenced during spine surgeries to detect a screw breach, prevent injury of neural elements, and ensure the most biomechanically sound instrumentation construct. To date, similar normative data for cervical lateral mass screws is limited, thus the utility of lateral mass screw testing remains unclear. To address this disparity, in this study the authors describe cumulative lateral mass screw stimulation threshold data in patients undergoing posterior cervical instrumentation with lateral mass screws...
December 9, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27935362/dramatic-radiographic-response-resulting-in-cerebrospinal-fluid-rhinorrhea-associated-with-sunitinib-therapy-in-recurrent-atypical-meningioma-case-report
#20
Amol Raheja, Howard Colman, Cheryl A Palmer, William T Couldwell
Sunitinib is a multiple tyrosine kinase inhibitor with antiangiogenic, cytostatic, and antimigratory activity for meningiomas. A recent clinical trial of sunitinib for treatment of recurrent Grade II and III meningiomas suggested potential efficacy in this population, but only 2 patients exhibited significant radiographic response with tumor volume reduction. The authors illustrate another such case and discuss a complication related to this dramatic tumor volume reduction in aggressive skull base meningiomas...
December 9, 2016: Journal of Neurosurgery
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