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Data breach

Imelda K Moise, Marilyn O Ruiz
INTRODUCTION: Identifying at-risk groups is a challenge in post-disaster psychosocial response. Geospatial techniques can support the design and deployment of targeted and tailored interventions. This study compared spatial patterns in the distribution of hospitalizations for substance abuse disorders and associated area-level predictors before and after Hurricane Katrina in New Orleans, Louisiana. METHODS: We used hospital data from the Louisiana Department of Health and Hospitals for 2004 (pre-Katrina) and 2008 (post-Katrina)...
October 13, 2016: Preventing Chronic Disease
Natasha Pahuja, Nimisha R Kumar, Rushad Shroff, Rohit Shetty, Rudy M M A Nuijts, Anuprita Ghosh, Abhijit Sinha-Roy, Shyam S Chaurasia, Rajiv R Mohan, Arkasubhra Ghosh
Purpose: In this study, we elucidated the differential expression of a set of local molecular factors in ectatic cone area of the cornea to uncover a functional cause for focal corneal weakening characteristic of the keratoconus (KC) disease. Methods: All human corneal samples were collected after approval of Institutional Ethics Committee and informed consent. Keratoconus patients were classified based on clinical parameters, topographical features, and structural deformity...
October 1, 2016: Investigative Ophthalmology & Visual Science
Sherali Zeadally, Jesús Téllez Isaac, Zubair Baig
For centuries, healthcare has been a basic service provided by many governments to their citizens. Over the past few decades, we have witnessed a significant transformation in the quality of healthcare services provided by healthcare organizations and professionals. Recent advances have led to the emergence of Electronic Health (E-health), largely made possible by the massive deployment and adoption of information and communication technologies (ICTs). However, cybercriminals and attackers are exploiting vulnerabilities associated primarily with ICTs, causing data breaches of patients' confidential digital health information records...
December 2016: Journal of Medical Systems
Ming-Ling Sher, Paul C Talley, Tain-Junn Cheng, Kuang-Ming Kuo
PURPOSE: The adoption of electronic medical records (EMR) is expected to better improve overall healthcare quality and to offset the financial pressure of excessive administrative burden. However, safeguarding EMR against potentially hostile security breaches from both inside and outside healthcare facilities has created increased patients' privacy concerns from all sides. The aim of our study was to examine the influencing factors of privacy protection for EMR by healthcare professionals...
October 4, 2016: HIM Journal
Isao Matsuo, Ryuji Hiramatsu
In most mammals, embryonic development and growth proceed in the maternal uterus. Mouse late blastocyst embryos implant on the uterine epithelium around embryonic day (E)4.5, and immediately afterward the whole embryo's shape is dynamically changed from a bowl-like shape to an elongated egg-cylinder until E5.5. Concurrently, mouse anterior-posterior (A-P) axis polarization occurs by the emergence of distal visceral endoderm (DVE) cells at the cellular and molecular levels as the proximal-distal (P-D) axis. The embryonic growth and axis polarization are considered to be controlled primarily by multiple growth factors' signaling...
September 30, 2016: Mechanisms of Development
Clemens Scott Kruse, Benjamin Frederick, Taylor Jacobson, D Kyle Monticone
BACKGROUND: The adoption of healthcare technology is arduous, and it requires planning and implementation time. Healthcare organizations are vulnerable to modern trends and threats because it has not kept up with threats. OBJECTIVE: The objective of this systematic review is to identify cybersecurity trends, including ransomware, and identify possible solutions by querying academic literature. METHODS: The reviewers conducted three separate searches through the CINAHL and PubMed (MEDLINE) and the Nursing and Allied Health Source via ProQuest databases...
September 20, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
Hao Wu, Ana R Rodriguez, Bernd W Spur, Venkat Venkataraman
A low-cost, easy-to-use and powerful model system is established to evaluate potential treatments that could ameliorate blood retinal barrier breach. An inflammatory factor, histamine, is demonstrated to compromise vessel integrity in the cultured retina through positive staining of IgG outside of the blood vessels. The effects of histamine itself and those of candidate drugs for potential treatments, such as lipoxin A4, are assessed using three parameters: blood vessel leakage via IgG immunostaining, activation of Müller cells via GFAP staining and change in neuronal dendrites through staining for MAP2...
2016: Journal of Visualized Experiments: JoVE
Shuang Wang, Xiaoqian Jiang, Siddharth Singh, Rebecca Marmor, Luca Bonomi, Dov Fox, Michelle Dow, Lucila Ohno-Machado
Accessing and integrating human genomic data with phenotypes are important for biomedical research. Making genomic data accessible for research purposes, however, must be handled carefully to avoid leakage of sensitive individual information to unauthorized parties and improper use of data. In this article, we focus on data sharing within the scope of data accessibility for research. Current common practices to gain biomedical data access are strictly rule based, without a clear and quantitative measurement of the risk of privacy breaches...
September 28, 2016: Annals of the New York Academy of Sciences
Jochen A S Lamote, Sarah Glorieux, Hans J Nauwynck, Herman W Favoreel
: Passage of the basement membrane (BM), which forms a barrier between epithelium and underlying lamina propria, represents an important step in the early pathogenesis of different alphaherpesviruses. Rho-GTPase signaling plays an important role in transmigration of cells across the BM during physiological and pathological processes. We reported earlier that the US3 protein kinase of the alphaherpesvirus pseudorabies virus (PRV) interferes with Rho GTPase signaling and causes a reorganisation of the host cell cytoskeleton which, as a consequence, enhances viral cell-to-cell spread in epithelial cell cultures...
September 28, 2016: Journal of Virology
Dan Matsumoto, Yuki Sawai, Masaki Yamada, Yuichi Namegaya, Tetsuya Shinozaki, Daisuke Takeda, Shigehiro Fujino, Koichiro Tanigawa, Atsunori Nakamura, Jessica E Pilarczyk
Erosional and sedimentary features associated with flooding have been documented in both modern and past cases. However, only a few studies have demonstrated the relationship between these features and the corresponding hydraulic conditions that produced them, making it difficult to evaluate the magnitude of paleo-flooding. This study describes the characteristics associated with inundation depth and flow direction, as well as the erosional and sedimentary features resulting from the disastrous flooding of the Kinu River, central Japan, in September 2015...
September 28, 2016: Scientific Reports
Christian Michelitsch, Thi Dan Linh Nguyen-Kim, Thorsten Jentzsch, Hans-Peter Simmen, Clément M L Werner
INTRODUCTION: Typical stabilisation of pelvic open book injuries consists of plate fixation of the symphysis. No previous literature has been published about the evaluation of screw placement and their trajectory with four oblique 4.5 mm screws using a four-hole plate in symphysis diastasis. The aim of this study was to define insertion points and angles of trajectory for crossed screw placement regardless of any plate design based on an analysis of three-dimensional computed tomography data sets...
September 14, 2016: Archives of Orthopaedic and Trauma Surgery
Cristina M Beltran-Aroca, Eloy Girela-Lopez, Eliseo Collazo-Chao, Manuel Montero-Pérez-Barquero, Maria C Muñoz-Villanueva
BACKGROUND: Respect for confidentiality is important to safeguard the well-being of patients and ensure the confidence of society in the doctor-patient relationship. The aim of our study is to examine real situations in which there has been a breach of confidentiality, by means of direct observation in clinical practice. METHODS: By means of direct observation, our study examines real situations in which there has been a breach of confidentiality in a tertiary hospital...
2016: BMC Medical Ethics
Eizen Kimura, Koki Hamada, Ryo Kikuchi, Koji Chida, Kazuya Okamoto, Shirou Manabe, Tomohiko Kuroda, Yasushi Matsumura, Toshihiro Takeda, Naoki Mihara
Issues related to ensuring patient privacy and data ownership in clinical repositories prevent the growth of translational research. Previous studies have used an aggregator agent to obscure clinical repositories from the data user, and to ensure the privacy of output using statistical disclosure control. However, there remain several issues that must be considered. One such issue is that a data breach may occur when multiple nodes conspire. Another is that the agent may eavesdrop on or leak a user's queries and their results...
2016: Studies in Health Technology and Informatics
John L Yovich, Birgit Alsbjerg, Jason L Conceicao, Peter M Hinchliffe, Kevin N Keane
The first PIVET algorithm for individualized recombinant follicle stimulating hormone (rFSH) dosing in in vitro fertilization, reported in 2012, was based on age and antral follicle count grading with adjustments for anti-Müllerian hormone level, body mass index, day-2 FSH, and smoking history. In 2007, it was enabled by the introduction of a metered rFSH pen allowing small dosage increments of ~8.3 IU per click. In 2011, a second rFSH pen was introduced allowing more precise dosages of 12.5 IU per click, and both pens with their individual algorithms have been applied continuously at our clinic...
2016: Drug Design, Development and Therapy
Go Yoshida, Koji Sato, Tokumi Kanemura, Toshiki Iwase, Daisuke Togawa, Yukihiro Matsuyama
STUDY DESIGN: Retrospective. PURPOSE: This study aims to investigate the accuracy of the oblique fluoroscopic view, based on preoperative computed tomography (CT) images for accurate placement of lumbosacral percutaneous pedicle screws (PPS). OVERVIEW OF LITERATURE: Although PPS misplacement has been reported as one of the main complications in minimally invasive spine surgery, there is no comparative data on the misplacement rate among different fluoroscopic techniques, or comparing such techniques with open procedures...
August 2016: Asian Spine Journal
Guo-Bo Chen, Sang Hong Lee, Matthew R Robinson, Maciej Trzaskowski, Zhi-Xiang Zhu, Thomas W Winkler, Felix R Day, Damien C Croteau-Chonka, Andrew R Wood, Adam E Locke, Zoltán Kutalik, Ruth J F Loos, Timothy M Frayling, Joel N Hirschhorn, Jian Yang, Naomi R Wray, Peter M Visscher
Genome-wide association studies (GWASs) have been successful in discovering SNP trait associations for many quantitative traits and common diseases. Typically, the effect sizes of SNP alleles are very small and this requires large genome-wide association meta-analyses (GWAMAs) to maximize statistical power. A trend towards ever-larger GWAMA is likely to continue, yet dealing with summary statistics from hundreds of cohorts increases logistical and quality control problems, including unknown sample overlap, and these can lead to both false positive and false negative findings...
August 24, 2016: European Journal of Human Genetics: EJHG
Swapna Bera, Rajiv K Kar, Susanta Mondal, Kalipada Pahan, Anirban Bhunia
Cell-penetrating peptides (CPPs) have shown promise in nonpermeable therapeutic drug delivery, because of their ability to transport a variety of cargo molecules across the cell membranes and their noncytotoxicity. Drosophila antennapedia homeodomain-derived CPP penetratin (RQIKIWFQNRRMKWKK), being rich in positively charged residues, has been increasingly used as a potential drug carrier for various purposes. Penetratin can breach the tight endothelial network known as the blood-brain barrier (BBB), permitting treatment of several neurodegenerative maladies, including Alzheimer's disease, Parkinson's disease, and Huntington's disease...
September 6, 2016: Biochemistry
Rebecca Bromwich
The mobile revolution is a watershed event across many fields, including health care. Now, electronic data storage, digital photography, smart phones and tablet devices present new opportunities for educators, researchers, and health care providers. Mobile technologies allow for new possibilities for physician collaboration as well as patient diagnosis, treatment and study. However, while it presents new opportunities, the mobile technological revolution in health care has brought about new risks to patient privacy...
May 2016: Health Law in Canada
Ozan L Abbas, Hüseyin Borman, Çağri A Uysal, Zeynep B Gönen, Leyla Aydin, Fatma Helvacioğlu, Şebnem Ilhan, Ayşe C Yazici
BACKGROUND: Cross-face nerve grafting combined with functional muscle transplantation has become the standard in reconstructing an emotionally controlled smile in complete irreversible facial palsy. However, the efficacy of this procedure depends on the ability of regenerating axons to breach two nerve coaptations and reinnervate endplates in denervated muscle. The current study tested the hypothesis that adipose-derived stem cells would enhance axonal regeneration through a cross-facial nerve graft and thereby enhance recovery of the facial nerve function...
August 2016: Plastic and Reconstructive Surgery
Timothy S Travers, Lisa Harlow, Ivan O Rosas, Bernadette R Gochuico, Ted R Mikuls, Sanjoy K Bhattacharya, Carlos J Camacho, Dana P Ascherman
Post-translational protein modifications such as citrullination have been linked to the breach of immune tolerance and clinical autoimmunity. Previous studies from our laboratory support this concept, demonstrating that autoantibodies targeting citrullinated isoforms of heat shock protein 90 (HSP90) are associated with rheumatoid arthritis complicated by interstitial lung disease. To further explore the relationship between citrullination and structural determinants of HSP90 immunogenicity, we employed a combination of ELISA-based epitope profiling, computational modeling, and mass-spectrometric sequencing of peptidylarginine deiminase (PAD)-modified protein...
September 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
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