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https://www.readbyqxmd.com/read/29776609/threshold-level-of-riemerella-anatipestifer-crossing-blood-brain-barrier-and-expression-profiles-of-immune-related-proteins-in-blood-and-brain-tissue-from-infected-ducks
#1
Shengdou Li, Xiaowei Gong, Qiwei Chen, Fuying Zheng, Guo Ji, Yongsheng Liu
Riemerella anatipestifer (R. anatipestifer) is a Gram-negative bacterium that crosses the blood-brain barrier (BBB) and causes meningitis with neurological symptoms in infected ducks. A threshold level of bacteremia must be reached before the BBB can be breached. In this study, the bacterial burden and expression profiles of immune-related proteins in blood and brain tissue samples from R. anatipestifer-infected ducks were investigated. The data showed that R. anatipestifer could cross the BBB with low-level bacteremia of 7...
June 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29770052/surveillance-of-laboratory-exposures-to-human-pathogens-and-toxins-canada-2016
#2
A Bienek, M Heisz, M Su
Background: Canada recently enacted legislation to authorize the collection of data on laboratory incidents involving a biological agent. This is done by the Public Health Agency of Canada (PHAC) as part of a comprehensive national program that protects Canadians from the health and safety risks posed by human and terrestrial animal pathogens and toxins. Objective: To describe the first year of data on laboratory exposure incidents and/or laboratory-acquired infections in Canada since the Human Pathogens and Toxins Regulations came into effect...
November 2, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29760102/broad-receptor-engagement-of-an-emerging-global-coronavirus-may-potentiate-its-diverse-cross-species-transmissibility
#3
Wentao Li, Ruben J G Hulswit, Scott P Kenney, Ivy Widjaja, Kwonil Jung, Moyasar A Alhamo, Brenda van Dieren, Frank J M van Kuppeveld, Linda J Saif, Berend-Jan Bosch
Porcine deltacoronavirus (PDCoV), identified in 2012, is a common enteropathogen of swine with worldwide distribution. The source and evolutionary history of this virus is, however, unknown. PDCoV belongs to the Deltacoronavirus genus that comprises predominantly avian CoV. Phylogenetic analysis suggests that PDCoV originated relatively recently from a host-switching event between birds and mammals. Insight into receptor engagement by PDCoV may shed light into such an exceptional phenomenon. Here we report that PDCoV employs host aminopeptidase N (APN) as an entry receptor and interacts with APN via domain B of its spike (S) protein...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29753624/a-critical-review-and-analysis-of-ethical-issues-associated-with-the-artificial-pancreas
#4
REVIEW
A Quintal, V Messier, R Rabasa-Lhoret, E Racine
The artificial pancreas combines a hormone infusion pump with a continuous glucose ontinuous glucose monitoring, supported by a dosing algorithm currently installed on the pump. It allows for dynamic infusions of insulin (and possibly other hormones such as glucagon) tailored to patient needs. For patients with type 1 diabetes the artificial pancreas has been shown to prevent more effectively hypoglycaemic events and hyperglycaemia than insulin pump therapy and has the potential to simplify care. However, the potential ethical issues associated with the upcoming integration of the artificial pancreas into clinical practice have not yet been discussed...
April 25, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29747609/high-prevalence-of-cesarean-section-births-in-private-sector-health-facilities-analysis-of-district-level-household-survey-4-dlhs-4-of-india
#5
Priyanka Singh, Gulfam Hashmi, Prafulla Kumar Swain
BACKGROUND: Worldwide rising cesarean section (CS) births is an issue of concern. In India, with increase in institutional deliveries there has also been an increase in cesarean section births. Aim of the study is to quantify the prevalence of cesarean section births in public and private health facility, and also to determine the factors associated with cesarean section births. METHODS: We analyzed data from district level household survey data 4 (DLHS-4) combined individual level dataset for 19 states/UTs of India comprising 24,398 deliveries resulting in 22,111 live births for year 2011...
May 10, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29724245/renal-cell-carcinoma-with-venous-extension-prediction-of-inferior-vena-cava-wall-invasion-by-mri
#6
Lisa C Adams, Bernhard Ralla, Yi-Na Y Bender, Keno Bressem, Bernd Hamm, Jonas Busch, Florian Fuller, Marcus R Makowski
BACKGROUND: Renal cell carcinoma (RCC) are accompanied by inferior vena cava (IVC) thrombus in up to 10% of the cases, with surgical resection remaining the only curative option. In case of IVC wall invasion, the operative procedure is more challenging and may even require IVC resection. This study aims to determine the diagnostic performance of contrast-enhanced magnetic resonance imaging (MRI) for the assessment of wall invasion by IVC thrombus in patients with RCC, validated with intraoperative findings...
May 3, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/29709854/geological-setting-control-of-flood-dynamics-in-lowland-rivers-poland
#7
Grzegorz Wierzbicki, Piotr Ostrowski, Tomasz Falkowski, Michał Mazgajski
We aim to answer a question: how does the geological setting affect flood dynamics in lowland alluvial rivers? The study area covers three river reaches: not trained, relatively large on the European scale, flowing in broad valleys cut in the landscape of old glacial plains. We focus on the locations where levees [both: a) natural or b) artificial] were breached during flood. In these locations we identify (1) the erosional traces of flood (crevasse channels) on the floodplain displayed on DEM derived from ALS LIDAR...
April 27, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29700390/using-a-genetic-test-result-in-the-care-of-family-members-how-does-the-duty-of-confidentiality-apply
#8
Michael Parker, Anneke Lucassen
The use of genetic and genomic testing is becoming more widespread in healthcare and more inherited explanations for family history of diseases or conditions are being uncovered. Currently, relevant genetic information is not always used in the care of family members who might benefit from it, because of health professionals' fears of inappropriately breaching another family member's confidence. Such examples are likely to increase as testing possibilities expand. Here we present the case for use of familial information in the care and treatment of family members...
April 27, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29681043/balancing-health-information-exchange-and-privacy-governance-from-a-patient-centred-connected-health-and-telehealth-perspective
#9
Craig E Kuziemsky, Shashi B Gogia, Mowafa Househ, Carolyn Petersen, Arindam Basu
OBJECTIVES:  Connected healthcare is an essential part of patient-centred care delivery. Technology such as telehealth is a critical part of connected healthcare. However, exchanging health information brings the risk of privacy issues. To better manage privacy risks we first need to understand the different patterns of patient-centred care in order to tailor solutions to address privacy risks. METHODS:  Drawing upon published literature, we develop a business model to enable patient-centred care via telehealth...
April 22, 2018: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29678714/transmuscle-ultrasonography-in-the-placement-of-thoracolumbar-pedicle-screws-a-cadaveric-study
#10
Cheng-Long Xie, Qi-Shan Huang, Long Wu, Lei Xu, Hai-Cheng Dou, Xiang-Yang Wang, Zhong-Ke Lin
BACKGROUND: Transpedicular screws fixation has a biomechanical advantage of improving fusion rates. In the posterior thoracolumbar immobilization, a large number of screws cause perforation to pedicle or vertebra body. Techniques as radiograph and CT were used to minimize this complication. However, ultrasound in detecting the pedicle breach during the placement of the screw in unknown. Our goal is to evaluate the sensitivity of ultrasound for detecting the breaches. METHODS: A B-type transducer was used for scanning 216 Titanium pins inserted into the cadaveric pedicle...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29665190/comparison-of-emergency-medicine-malpractice-cases-involving-residents-to-non-resident-cases
#11
Kiersten L Gurley, Shamai A Grossman, Margaret Janes, C Winnie Yu-Moe, Ellen Song, Carrie D Tibbles, Nathan I Shapiro, Carlo L Rosen
BACKGROUND: Data are lacking on how emergency medicine (EM) malpractice cases with resident involvement differs from cases that do not name a resident. OBJECTIVES: To compare malpractice case characteristics in cases where a resident is involved (resident case) to cases that do not involve a resident (non-resident case) and to determine factors that contribute to malpractice cases utilizing EM as a model for malpractice claims across other medical specialties. METHODS: We used data from the Controlled Risk Insurance Company (CRICO) Strategies' division Comparative Benchmarking System (CBS) to analyze open and closed EM cases asserted from 2009-2013...
April 17, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29659793/good-practices-and-challenges-in-addressing-poliomyelitis-and-measles-in-the-european-union
#12
John Kinsman, Svenja Stöven, Fredrik Elgh, Pilar Murillo, Michael Sulzner
Background: All European Union (EU) and European Economic Area (EEA) Member States have pledged to ensure political commitment towards sustaining the region's poliomyelitis-free status and eliminating measles. However, there remain significant gaps between policy and practice in many countries. This article reports on an assessment conducted for the European Commission that aimed to support improvements in preparedness and response to poliomyelitis and measles in Europe. Methods: A documentary review was complemented by qualitative interviews with professionals working in International and EU agencies, and in at-risk or recently affected EU/EEA Member States (six each for poliomyelitis and measles)...
April 6, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29656324/the-organic-pollutant-status-of-rivers-in-bosnia-and-herzegovina-as-determined-by-a-combination-of-active-and-passive-sampling-methods
#13
Christopher Harman, Merete Grung, Jasmina Djedjibegovic, Aleksandra Marjanovic, Eirik Fjeld, Hans Fredrik Veiteberg Braaten, Miroslav Sober, Thorjørn Larssen, Sissel Brit Ranneklev
There is an overall lack of data concerning the pollution status of Bosnia Herzegovina, which is confounded by fragmented national environmental management. The present study aimed to provide some initial data for concentrations of priority substances in two major Bosnian Rivers, using two types of passive sampler (PS) as well as by using high volume water sampling (HVWS). Overall, concentrations of most persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs) and legacy pesticides, were shown to be low...
April 15, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29651593/cervical-pedicle-screw-instrumentation-is-more-reliable-with-o-arm-based-3d-navigation-analysis-of-cervical-pedicle-screw-placement-accuracy-with-o-arm-based-3d-navigation
#14
Sourabh Chachan, Hamid Ramatullah Bin Abd Razak, Wee Lim Loo, John Carson Allen, Dinesh Shree Kumar
PURPOSE: Despite proven biomechanical superiority and resultant superior clinical outcomes, pedicle instrumentation in cervical spine is not widely practiced due to technical difficulties, steep learning curve, and possible potential catastrophic complications due to screw misplacement. This study was undertaken with the purpose to evaluate the feasibility, accuracy, and complications of cervical pedicle screw instrumentation solely using O-arm-based 3D navigation technology. METHODS: Prospectively maintained data from a single-surgeon case series were retrospectively analyzed...
April 12, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29643052/the-effectiveness-of-health-care-information-technologies-evaluation-of-trust-security-beliefs-and-privacy-as-determinants-of-health-care-outcomes
#15
Victoria Kisekka, Justin Scott Giboney
BACKGROUND: The diffusion of health information technologies (HITs) within the health care sector continues to grow. However, there is no theory explaining how success of HITs influences patient care outcomes. With the increase in data breaches, HITs' success now hinges on the effectiveness of data protection solutions. Still, empirical research has only addressed privacy concerns, with little regard for other factors of information assurance. OBJECTIVE: The objective of this study was to study the effectiveness of HITs using the DeLone and McLean Information Systems Success Model (DMISSM)...
April 11, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29629434/contextualizing-naturalistic-driving-data-in-a-rural-state-among-drivers-with-and-without-obstructive-sleep-apnea
#16
Jeffrey D Dawson, Elizabeth Bair, Nazan Askan, Kelly Sewell, Jon Tippin, Matthew Rizzo
In naturalistic studies, Global Positioning System (GPS) data and date/time stamps can link driver exposure to specific environments (e.g., road types, speed limits, night driving, etc.), providing valuable context for analyzing critical events, such as crashes, near crashes, and breaches of accelerometer limits. In previous work, we showed how to automate this contextualization, using GPS data obtained at 1 Hz and merging this with Geographic Information Systems (GIS) databases maintained by the Iowa Department of Transportation (DOT)...
June 2017: Proceedings of the ... International Driving Symposium on Human Factors in Driver Assessment, Training, and Vehicle Design
https://www.readbyqxmd.com/read/29623779/long-term-use-of-darunavir-ritonavir-containing-regimens-in-daily-practice-in-belgium-retrospective-observational-cohort-data-of-1701-hiv-patients
#17
Stéphane De Wit, Eric Florence, Linos Vandekerckhove, Bernard Vandercam, Jean-Christophe Goffard, Eric Van Wijngaerden, Michel Moutschen, Remy Demeester, Pushpike Thilakarathne, Hilde Piryns
Background Once daily (QD) ritonavir or cobicistat-boosted darunavir (DRV/b), in combination with other antiretrovirals (ARVs), is recommended as a first-line option for human immunodeficiency virus-infected patients in European and USA guidelines. The objective of this study was to analyse the outcomes of DRV/r QD-based antiretroviral therapy (ART) regimens in real-life settings. Methods This is an observational, non-interventional, non-comparative, retrospective, multicentre cohort study. Data were collected from the databases of eight Belgian AIDS Reference Centres...
April 6, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29618959/proficiency-of-first-year-podiatric-medical-residents-in-the-use-of-electronic-medical-records
#18
Rebecca Meehan, Jill Kawalec, Bryan Caldwell, David Putman
Objectives: The aim of this study was to survey podiatric residency directors to evaluate the proficiency of first-year podiatric medical residents in the use of electronic medical records and its potential impact on medical care. Methods: An online survey consisting of Likert-scale, multiple-choice, and open-ended questions was sent via email to 216 podiatric residency directors. Questions were directed toward the level of proficiency in electronic medical records expected at the beginning of residency training and the impact on patient care of residents' inexperience with electronic medical records...
2018: Perspectives in Health Information Management
https://www.readbyqxmd.com/read/29605444/performance-characteristics-of-transrectal-shear-wave-elastography-swe-imaging-in-the-evaluation-of-clinically-localised-prostate-cancer-a-prospective-study
#19
Cheng Wei, Chunhui Li, Magdalena Szewczyk-Bieda, Dilip Upreti, Stephen Lang, Zhihong Huang, Ghulam Nabi
OBJECTIVE: To test the diagnostic accuracy of SWE for the detection and phenotypic characterisation of PCa compared with whole-mount radical prostatectomy histopathology. MATERIALS AND METHODS: This was a prospective protocol-driven diagnostic accuracy study. 212 consecutive men undergoing laparoscopic radical prostatectomy (LRP) for clinically localised PCa were recruited into the study. Quantitative stiffness data of the prostate gland was obtained in each patient using an endocavitary transrectal transducer before LRP and compared with detailed histopathological examination of radical prostatectomy specimen using 3-D printing mold based technology ensuring improved image-histology orientation...
March 29, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29578336/structural-evidence-for-rifampicin-monooxygenase-inactivating-rifampicin-by-cleaving-its-ansa-bridge
#20
Li-Kai Liu, Yumin Dai, Heba Abdelwahab, Pablo Sobrado, John J Tanner
Rifampicin monooxygenase (RIFMO) decreases the potency of rifampicin (RIF) by converting it to oxidative products. Further decomposition of RIF has been observed in bacteria producing RIFMO and contributes to RIFMO-mediated drug resistance. Here we report the first crystal structure of RIFMO in complex with the hydroxylated RIF product. The 2.10 Å resolution structure reveals a breach of the ansa aliphatic chain of RIF between the naphthoquinone C2 and the amide nitrogen N1. Our data suggest that RIFMO catalyzes the hydroxylation of RIF at the C2 atom followed by cleavage of the ansa linkage, which leads to inactivation of the antibiotic by preventing key contacts with the RNA polymerase target...
March 26, 2018: Biochemistry
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