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https://www.readbyqxmd.com/read/28911212/apposition-to-endometrial-epithelial-cells-activates-mouse-blastocysts-for-implantation
#1
Peter T Ruane, Stéphane C Berneau, Rebekka Koeck, Jessica Watts, Susan J Kimber, Daniel R Brison, Melissa Westwood, John D Aplin
STUDY QUESTION: How do interactions between blastocyst-stage embryos and endometrial epithelial cells regulate the early stages of implantation in an in vitro model? SUMMARY ANSWER: Mouse blastocyst apposition with human endometrial epithelial cells initiates trophectoderm differentiation to trophoblast, which goes on to breach the endometrial epithelium. WHAT IS KNOWN ALREADY: In vitro models using mouse blastocysts and human endometrial cell lines have proven invaluable in the molecular characterisation of embryo attachment to endometrial epithelium at the onset of implantation...
September 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28905258/is-biomedical-research-protected-from-predatory-reviewers
#2
Aceil Al-Khatib, Jaime A Teixeira da Silva
Authors endure considerable hardship carrying out biomedical research, from generating ideas to completing their manuscripts and submitting their findings and data (as is increasingly required) to a journal. When researchers submit to journals, they entrust their findings and ideas to editors and peer reviewers who are expected to respect the confidentiality of peer review. Inherent trust in peer review is built on the ethical conduct of authors, editors and reviewers, and on the respect of this confidentiality...
September 13, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28864077/phenotype-and-antimicrobial-activity-of-th17-cells-induced-by-propionibacterium-acnes-strains-associated-with-healthy-and-acne-skin
#3
George W Agak, Stephanie Kao, Kelsey Ouyang, Min Qin, David Moon, Ahsan Butt, Jenny Kim
Studies of human skin microbiome suggest that Propionibacterium acnes strains may contribute differently to skin health and disease. However, the immune phenotype and functions of Th17 cells induced by healthy (PH) vs. acne (PA) skin-associated P. acnes strains are currently unknown. We stimulated PBMCs from healthy donors and observed that PA strains induce higher IL-17 levels than PH strains. We next generated PH and PA strain-specific Th17 clones and show that P. acnes strains induce Th17 cells of varied phenotype and function that are stable in the presence of IL-2 and IL-23...
August 29, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28828877/stigma-and-discrimination-within-the-ethiopian-health-care-settings-views-of-inpatients-living-with-human-immunodeficiency-virus-and-acquired-immune-deficiency-syndrome
#4
Befekadu S Wodajo, Gloria Thupayagale-Tshweneagae, Oluwaseyi A Akpor
BACKGROUND: Stigma and discrimination attached to human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) have been recognised as a major obstacle to HIV prevention, treatment, care and support throughout the world. Stigma and discrimination are more devastating when they occur in health care settings where it is least expected. AIM: To explore the factors attributable to stigma and discrimination of people living with HIV in two Ethiopian rural hospitals on what they thought of health care professionals (HCPs) attending to them...
July 31, 2017: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/28827374/so-much-data-so-little-time-eplant-steps-into-the-breach-for-plant-researchers
#5
Nancy Rosenbaum Hofmann
No abstract text is available yet for this article.
August 21, 2017: Plant Cell
https://www.readbyqxmd.com/read/28821546/a-supervised-statistical-learning-approach-for-accurate-legionella-pneumophila-source-attribution-during-outbreaks
#6
Andrew H Buultjens, Kyra Y L Chua, Sarah L Baines, Jason Kwong, Wei Gao, Zoe Cutcher, Stuart Adcock, Susan Ballard, Mark B Schultz, Takehiro Tomita, Nela Subasinghe, Glen P Carter, Sacha J Pidot, Lucinda Franklin, Torsten Seemann, Anders Gonçalves Da Silva, Benjamin P Howden, Timothy P Stinear
Public health agencies are increasingly relying on genomics during Legionnaires' disease investigations. However, the causative bacterium (Legionella pneumophila) has an unusual population structure with extreme temporal and spatial genome sequence conservation. Furthermore, Legionnaires' disease outbreaks can be caused by multiple L. pneumophila genotypes in a single source. These factors can confound cluster identification using standard phylogenomic methods. Here, we show that a statistical learning approach based onL...
August 18, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28800378/security-events-and-vulnerability-data-for-cybersecurity-risk-estimation
#7
Luca Allodi, Fabio Massacci
Current industry standards for estimating cybersecurity risk are based on qualitative risk matrices as opposed to quantitative risk estimates. In contrast, risk assessment in most other industry sectors aims at deriving quantitative risk estimations (e.g., Basel II in Finance). This article presents a model and methodology to leverage on the large amount of data available from the IT infrastructure of an organization's security operation center to quantitatively estimate the probability of attack. Our methodology specifically addresses untargeted attacks delivered by automatic tools that make up the vast majority of attacks in the wild against users and organizations...
August 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28799104/accuracy-of-837-pedicle-screw-positions-in-degenerative-lumbar-spine-with-conventional-open-surgery-evaluated-by-computed-tomography
#8
Ilkka Saarenpää, Timo Laine, Jussi Hirvonen, Saija Hurme, Esa Kotilainen, Jaakko Rinne, Katariina Korhonen, Janek Frantzén
BACKGROUND: The spatial and directional accuracy of the positioning of pedicle screws in the lumbosacral spine with conventional open surgery assessed by computed tomography (CT) has been published in several studies, systematic reviews and meta-analyses with a short-term follow-up. Inaccurate pedicle screw insertion may cause neurologic symptoms and weakens the construct. METHODS: The data of 147 patients operated on with transpedicular screw fixation based on anatomical landmarks, supported by fluoroscopy, by a senior neurosurgeon in our clinic between 2000 and 2010 were analyzed retrospectively...
August 10, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28797268/do-expanded-seven-day-nhs-services-improve-clinical-outcomes-analysis-of-comparative-institutional-performance-from-the-nhs-services-seven-days-a-week-project-2013-2016
#9
Hoong-Wei Gan, Danny Jon Nian Wong, Benjamin John Floyd Dean, Alistair Scott Hall
BACKGROUND: The cause of adverse weekend clinical outcomes remains unknown. In 2013, the "NHS Services, Seven Days a Week" project was initiated to improve access to services across the seven-day week. Three years on, we sought to analyse the impact of such changes across the English NHS. METHODS: Aggregated trust-level data on crude mortality rates, Summary Hospital-Level Mortality Indicator (SHMI), mean length of stay (LOS), A&E admission and four-hour breach rates were obtained from national Hospital Episode Statistics and A&E datasets across the English NHS, excluding mental and community health trusts...
August 10, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28794573/quantitative-assessment-of-pm2-5-sources-and-their-seasonal-variation-in-krakow
#10
Lucyna Samek, Z Stegowski, L Furman, K Styszko, K Szramowiat, J Fiedor
In industry areas of Poland such as Silesia or urban sites like Krakow and some other cities, the levels of pollutants frequently breach air quality standards. Particulate matter (PM) is the most important constituent of atmospheric pollution. Beginning on 1st February 2014 until 31st January 2015, the samples of fine particulate matter PM2.5 (aerodynamic diameter of particles less than or equal to 2.5 μm) were collected at a site in the south-eastern Krakow urban background area. During this period, 194 samples were taken...
2017: Water, Air, and Soil Pollution
https://www.readbyqxmd.com/read/28782026/buried-shallow-fault-slip-from-the-south-napa-earthquake-revealed-by-near-field-geodesy
#11
Benjamin A Brooks, Sarah E Minson, Craig L Glennie, Johanna M Nevitt, Tim Dawson, Ron Rubin, Todd L Ericksen, David Lockner, Kenneth Hudnut, Victoria Langenheim, Andrew Lutz, Maxime Mareschal, Jessica Murray, David Schwartz, Dana Zaccone
Earthquake-related fault slip in the upper hundreds of meters of Earth's surface has remained largely unstudied because of challenges measuring deformation in the near field of a fault rupture. We analyze centimeter-scale accuracy mobile laser scanning (MLS) data of deformed vine rows within ±300 m of the principal surface expression of the M (magnitude) 6.0 2014 South Napa earthquake. Rather than assuming surface displacement equivalence to fault slip, we invert the near-field data with a model that allows for, but does not require, the fault to be buried below the surface...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28780348/integration-of-in-silico-approaches-to-determination-of-endocrine-disrupting-perfluorinated-chemicals-binding-potency-with-steroidogenic-acute-regulatory-protein
#12
K Kranthi Kumar, B Uma Devi, P Neeraja
A myriad of perfluorinated compounds (PFCs) have the ability to interfere with steroidogenic acute regulatory (StAR) protein. Consequently, PFCs breaches cholesterol biotransformation in mitochondria and cause fatal consequences in steroidogenesis, however, these were poorly characterized. In the present study, we have evaluated toxic potencies, nuclear mediated probabilities and interaction profiles with StAR of PFCs using computational system biology tools. Toxicity endpoints revealed that PFCs contain high carcinogenicity, developmental toxicity, skin sensitization effects with low mutagenic activity...
August 3, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28760033/minimally-invasive-guidewireless-navigated-pedicle-screw-placement-a-technical-report-and-case-series
#13
Brandon W Smith, Jacob R Joseph, Michael Kirsch, Mary Oakley Strasser, Jacob Smith, Paul Park
OBJECTIVE Percutaneous pedicle screw insertion (PPSI) is a mainstay of minimally invasive spinal surgery. Traditionally, PPSI is a fluoroscopy-guided, multistep process involving traversing the pedicle with a Jamshidi needle, placement of a Kirschner wire (K-wire), placement of a soft-tissue dilator, pedicle tract tapping, and screw insertion over the K-wire. This study evaluates the accuracy and safety of PPSI with a simplified 2-step process using a navigated awl-tap followed by navigated screw insertion without use of a K-wire or fluoroscopy...
August 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28745562/evaluation-of-the-awareness-and-effectiveness-of-it-security-programs-in-a-large-publicly-funded-health-care-system
#14
Shelanne L Hepp, Rima C Tarraf, Arden Birney, Mubashir Aslam Arain
BACKGROUND: Electronic health records are becoming increasingly common in the health care industry. Although information technology (IT) poses many benefits to improving health care and ease of access to information, there are also security and privacy risks. Educating health care providers is necessary to ensure proper use of health information systems and IT and reduce undesirable outcomes. OBJECTIVE: This study evaluated employees' awareness and perceptions of the effectiveness of two IT educational training modules within a large publicly funded health care system in Canada...
January 1, 2017: HIM Journal
https://www.readbyqxmd.com/read/28726170/prescribing-trends-in-a-glaucoma-clinic-and-adherence-to-egs-guidelines-a-retrospective-non-interventional-single-center-uk-study
#15
Mark Fajgenbaum, Ejaz Ansari
INTRODUCTION: The purpose of this study was to determine prescribing trends in a specialist glaucoma clinic in the UK. Specifically, the aims were to determine which drugs were prescribed as first-, second-, and third-line treatment, the persistence of first-, second-, and third-line treatment regimens, and the proportion of treatment decisions conforming to the European Glaucoma Society (EGS) guidelines. METHODS: A retrospective, non-interventional, single-center, case-note review was performed on a cohort of consecutive patients presenting to a specialist glaucoma clinic for follow-up...
July 19, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28713781/the-metalloprotease-mpr1-engages-annexina2-to-promote-the-transcytosis-of-fungal-cells-across-the-blood-brain-barrier
#16
Sarisa Na Pombejra, Michelle Salemi, Brett S Phinney, Angie Gelli
Eukaryotic pathogens display multiple mechanisms for breaching the blood-brain barrier (BBB) and invading the central nervous system (CNS). Of the fungal spp., that cause disease in mammals, only some cross brain microvascular endothelial cells which constitute the BBB, and invade the brain. Cryptococcus neoformans, the leading cause of fungal meningoencephalitis, crosses the BBB directly by transcytosis or by co-opting monocytes. We previously determined that Mpr1, a secreted fungal metalloprotease, facilitates association of fungal cells to brain microvascular endothelial cells and we confirmed that the sole expression of CnMPR1 endowed S...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28709106/microcosms-for-evaluating-microbial-indicator-persistence-and-mobilization-in-fluvial-sediments-during-rainfall-events
#17
Julia Martín-Díaz, Cristina García-Aljaro, Míriam Pascual-Benito, Belén Galofré, Anicet R Blanch, Francisco Lucena
Mediterranean rivers, which are subject to long, dry periods and heavy rainfall events, could be particularly useful for understanding future climate scenarios. This study generated microcosms that mimicked riverbank sediment resuspension into the water of a typical Mediterranean river as a consequence of heavy rainfall. The mobilization and inactivation of six fecal pollution indicators and microbial source tracking markers were evaluated. The T90 values in the sediments were: 4 days for sorbitol-fermenting Bifidobacterium, 11 days for culturable E...
July 9, 2017: Water Research
https://www.readbyqxmd.com/read/28704331/mis-single-position-lateral-and-oblique-lateral-lumbar-interbody-fusion-and-bilateral-pedicle-screw-fixation-feasibility-and-perioperative-results
#18
Daniel J Blizzard, J Alex Thomas
STUDY DESIGN: Retrospective review of prospectively collected data of the first 72 consecutive patients treated with single-position one- or two-level lateral (LLIF) or oblique lateral interbody fusion (OLLIF) with bilateral percutaneous pedicle screw and rod fixation by a single spine surgeon. OBJECTIVE: To evaluate the clinical feasibility, accuracy, and efficiency of a single-position technique for LLIF and OLLIF with bilateral pedicle screw and rod fixation...
July 12, 2017: Spine
https://www.readbyqxmd.com/read/28701806/meteorological-and-landscape-influences-on-pollen-beetle-immigration-into-oilseed-rape-crops
#19
Matthew P Skellern, Sue J Welham, Nigel P Watts, Samantha M Cook
Heavy reliance on pesticide inputs to maintain crop yields has been an important aspect of agricultural intensification. Insecticide use has had detrimental impacts on pollinators and natural pest control agents, contributing to a decline in associated ecosystem services, and has also led to resistance development in pest populations. Throughout Europe, in oilseed rape (Brassica napus L.) crops, prophylactic use of insecticides against pollen beetles (Meligethes aeneus F. also known as Brassicogethes aeneus) has led to such issues, and there is an urgent need to develop more sustainable pest management practices for the crop...
April 1, 2017: Agriculture, Ecosystems & Environment
https://www.readbyqxmd.com/read/28698284/breaching-peripheral-tolerance-promotes-the-production-of-hiv-1-neutralizing-antibodies
#20
Kristin M S Schroeder, Amanda Agazio, Pamela J Strauch, Sean T Jones, Scott B Thompson, Michael S Harper, Roberta Pelanda, Mario L Santiago, Raul M Torres
A subset of characterized HIV-1 broadly neutralizing antibodies (bnAbs) are polyreactive with additional specificities for self-antigens and it has been proposed immunological tolerance may present a barrier to their participation in protective humoral immunity. We address this hypothesis by immunizing autoimmune-prone mice with HIV-1 Envelope (Env) and characterizing the primary antibody response for HIV-1 neutralization. We find autoimmune mice generate neutralizing antibody responses to tier 2 HIV-1 strains with alum treatment alone in the absence of Env...
August 7, 2017: Journal of Experimental Medicine
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