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https://www.readbyqxmd.com/read/28320112/multiple-sclerosis-patients-understanding-and-preferences-for-risks-and-benefits-of-disease-modifying-drugs-a-systematic-review
#1
REVIEW
Gurpreet K Reen, Eli Silber, Dawn W Langdon
BACKGROUND: Multiple sclerosis (MS) patients are faced with complex risk-benefit profiles of disease-modifying drugs (DMDs) when making treatment decisions. For effective shared decision-making, MS patients should understand the risks and benefits of DMDs and make treatment decisions based on personal preferences. METHODS: This is an inclusive systematic review to primarily assess current understanding of MS patients for information about DMDs provided during the standard healthcare system...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319584/episode-of-care-characteristics-and-costs-for-hip-and-knee-replacement-surgery-in-hospitals-belonging-to-the-high-value-health-care-collaborative-compared-with-similar-hospitals-in-the-same-health-care-markets
#2
William B Weeks, William J Schoellkopf, David J Ballard, Gary S Kaplan, Brent James, James N Weinstein
BACKGROUND: To inform consumers and restrain health care cost growth, efforts to promote transparency and to reimburse for care episodes are accelerating in the United States. OBJECTIVE: To compare characteristics and costs of 30-day episode of care for hip and knee replacement occurring in High Value Healthcare Collaborative (HVHC)-member hospitals to those occurring in like non-HVHC-member hospitals in the same 15 health care markets before interventions by HVHC members to improve health care value for those interventions...
March 17, 2017: Medical Care
https://www.readbyqxmd.com/read/28317607/nutritional-aspects-of-dysphagia-management
#3
C Gallegos, E Brito-de la Fuente, P Clavé, A Costa, G Assegehegn
This chapter describes the nutritional aspects of dysphagia management by starting with the definition of these two conditions (dysphagia and malnutrition) that share three main clinical characteristics: (a) their prevalence is very high, (b) they can lead to severe complications, and (c) they are frequently underrecognized and neglected conditions. From an anatomical standpoint, dysphagia can result from oropharyngeal and/or esophageal causes; from a pathophysiological perspective, dysphagia can be caused by organic or structural diseases (either benign or malignant) or diseases causing impaired physiology (mainly motility and/or perception disorders)...
2017: Advances in Food and Nutrition Research
https://www.readbyqxmd.com/read/28317146/immunization-of-looked-after-children-and-young-people-a-review-of-the-literature
#4
REVIEW
S Walton, H Bedford
BACKGROUND: Numbers of looked-after children and young people (LACYP) in the UK have risen over the last seven years. Looked-after children and young people should receive regular health assessments, including establishing immunization status and, if needed, developing a health plan to achieve full immunization. The Department for Education publish data on immunizations among LACYP to monitor both how well they are immunized and service performance. METHODS: A literature review was conducted using four databases (PubMed, Embase, Scopus and Web of Science) on immunization status of LACYP, factors affecting uptake and challenges to immunization, and interventions to improve immunization rates...
March 19, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28315115/interprofessional-communication-between-community-pharmacists-and-general-practitioners-a-qualitative-study
#5
Marina Weissenborn, Walter E Haefeli, Frank Peters-Klimm, Hanna M Seidling
Background While collaboration between community pharmacists (CPs) and general practitioners (GPs) is essential to provide comprehensive patient care, their communication often is scarce and hampered by multiple barriers. Objective We aimed to assess both professions' perceptions of interprofessional communication with regard to content and methods of communication as a basis to subsequently develop best-practice recommendations for information exchange. Setting Ambulatory care setting in Germany. Method CPs and GPs shared their experience in focus groups and in-depth interviews which were conducted using a semi-structured interview guideline...
March 17, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28314937/phylogenetic-analysis-of-idd-gene-family-and-characterization-of-its-expression-in-response-to-flower-induction-in-malus
#6
Sheng Fan, Dong Zhang, Libo Xing, Siyan Qi, Lisha Du, Haiqin Wu, Hongxia Shao, Youmei Li, Juanjuan Ma, Mingyu Han
Although INDETERMINATE DOMAIN (IDD) genes encoding specific plant transcription factors have important roles in plant growth and development, little is known about apple IDD (MdIDD) genes and their potential functions in the flower induction. In this study, we identified 20 putative IDD genes in apple and named them according to their chromosomal locations. All identified MdIDD genes shared a conserved IDD domain. A phylogenetic analysis separated MdIDDs and other plant IDD genes into four groups. Bioinformatic analysis of chemical characteristics, gene structure, and prediction of protein-protein interactions demonstrated the functional and structural diversity of MdIDD genes...
March 17, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28314727/transcriptomic-analyses-elucidate-adaptive-differences-of-closely-related-strains-of-p-aeruginosa-in-fuel
#7
Thusitha S Gunasekera, Loryn L Bowen, Carol E Zhou, Susan C Howard-Byerly, William S Foley, Richard C Striebich, Larry C Dugan, Oscar N Ruiz
Pseudomonas aeruginosa can utilize hydrocarbons, but different strains have varying degrees of adaptation despite their highly conserved genome. P. aeruginosa ATCC 33988 is highly adapted to hydrocarbons while strain PAO1, a human pathogen, is less-adapted and degrades jet fuel at a slower rate than does ATCC 33988. We investigated fuel specific transcriptomic differences between these strains in order to ascertain the underling mechanisms utilized by the adapted strain to proliferate in fuel. During growth in fuel, the genes related to alkane degradation, heat-shock response, membrane proteins, efflux pumps and several novel genes were upregulated in ATCC 33988...
March 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28314179/online-maternity-information-seeking-among-lesbian-bisexual-and-queer-women
#8
Emily H Ruppel, Hannah E Karpman, Carolyn E Delk, Mallory Merryman
OBJECTIVE: recent research has concluded that barriers to maternity health care exist for lesbian, bisexual, and queer women. This mixed methods study aims to understand patterns in seeking and sharing online health information for LBQ women attempting conception. DESIGN: researchers performed a qualitative content analysis of 400 discussions in lesbian-oriented Facebook groups, containing 1764 total instances of text. 400 discussions from heterosexual-oriented conception and parenting Facebook groups were examined for comparison purposes, though they will not be the focus of this analysis...
March 1, 2017: Midwifery
https://www.readbyqxmd.com/read/28306613/estimating-local-chlamydia-incidence-and-prevalence-using-surveillance-data
#9
Joanna Lewis, Peter J White
BACKGROUND: Understanding patterns of chlamydia prevalence is important for addressing inequalities and planning cost-effective control programs. Population-based surveys are costly; the best data for England come from the Natsal national surveys, which are only available once per decade, and are nationally representative but not powered to compare prevalence in different localities. Prevalence estimates at finer spatial and temporal scales are required. METHODS: We present a method for estimating local prevalence by modeling the infection, testing and treatment processes...
March 15, 2017: Epidemiology
https://www.readbyqxmd.com/read/28306511/phagebook-the-social-network
#10
Alexander P Hynes, Sylvain Moineau
Much like social networks are used to connect with friends or relatives, bacteria communicate with relatives through quorum sensing. Viruses, though, were thought to be asocial-until now. Erez et al. (2017) reveal that viruses are also sharing information with relatives.
March 16, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28304332/a-wellness-mobile-application-for-smart-health-pilot-study-design-and-results
#11
Giovanna Sannino, Manolo Forastiere, Giuseppe De Pietro
Wellness is one of the main factors crucial in the avoidance of illness or disease. Experience has shown that healthy lifestyle programs are an important strategy to prevent the major shared risk factors for many diseases including cardiovascular diseases, strokes, diabetes, obesity, and hypertension. Within the ambit of the Smart Health 2.0 project, a Wellness App has been developed which has the aim of providing people with something similar to a personal trainer. This Wellness App is able to gather information about the subject, to classify her/him by evaluating some of her/his specific characteristics (physical parameters and lifestyle) and to make personal recommendations to enhance her/his well-being...
March 17, 2017: Sensors
https://www.readbyqxmd.com/read/28304110/perceptions-of-health-among-black-adults-living-in-a-diverse-urban-community
#12
Dahnika Sachs, Jill N Peltzer, Jerrihlyn L McGee
OBJECTIVE: The Robert Wood Johnson Foundation's culture of health initiative advocates for making health a shared value. Health cannot be a shared value without an understanding of how health is defined and perceived. The purpose of this qualitative descriptive study was to examine community members' perceptions of health and influencing factors, including health care services. DESIGN AND SAMPLE: Data were collected through a purposive sample of nine focus groups with 52 participants who were primarily Black (94%) and female (65%)...
March 17, 2017: Public Health Nursing
https://www.readbyqxmd.com/read/28303240/ensuring-privacy-when-integrating-patient-based-datasets-new-methods-and-developments-in-record-linkage
#13
Adrian P Brown, Anna M Ferrante, Sean M Randall, James H Boyd, James B Semmens
In an era where the volume of structured and unstructured digital data has exploded, there has been an enormous growth in the creation of data about individuals that can be used for understanding and treating disease. Joining these records together at an individual level provides a complete picture of a patient's interaction with health services and allows better assessment of patient outcomes and effectiveness of treatment and services. Record linkage techniques provide an efficient and cost-effective method to bring individual records together as patient profiles...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28303239/epidemiology-of-ebola-virus-disease-in-the-western-area-region-of-sierra-leone-2014-2015
#14
Margaret Lamunu, Olushayo Oluseun Olu, James Bangura, Zabulon Yoti, Thomas Takpau Samba, David Kabba Kargbo, Foday Mohamed Dafae, Muhammad Ali Raja, Noah Sempira, Michael Lyazi Ivan, Aarti Sing, Fredson Kurti-George, Negusu Worku, Pamela Mitula, Louisa Ganda, Robert Samupindi, Roland Conteh, Kande-Bure Kamara, Beatrice Muraguri, Michael Kposowa, Joseph Charles, Malimbo Mugaga, Christopher Dye, Anshu Banerjee, Pierre Formenty, Brima Kargbo, Raymond Bruce Aylward
INTRODUCTION: Western Area (WA) of Sierra Leone including the capital, Freetown, experienced an unprecedented outbreak of Ebola from 2014 to 2015. At the onset of the epidemic, there was little information about the epidemiology, transmission dynamics, and risk factors in urban settings as previous outbreaks were limited to rural/semi-rural settings. This study, therefore, aimed to describe the epidemiology of the outbreak and the factors which had most impact on the transmission of the epidemic and whether there were different drivers from those previously described in rural settings...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28302743/heart-failure-in-pediatric-patients-with-congenital-heart-disease
#15
Robert B Hinton, Stephanie M Ware
Heart failure (HF) is a complex clinical syndrome resulting from diverse primary and secondary causes and shared pathways of disease progression, correlating with substantial mortality, morbidity, and cost. HF in children is most commonly attributable to coexistent congenital heart disease, with different risks depending on the specific type of malformation. Current management and therapy for HF in children are extrapolated from treatment approaches in adults. This review discusses the causes, epidemiology, and manifestations of HF in children with congenital heart disease and presents the clinical, genetic, and molecular characteristics that are similar or distinct from adult HF...
March 17, 2017: Circulation Research
https://www.readbyqxmd.com/read/28302593/outcomes-in-child-health-exploring-the-use-of-social-media-to-engage-parents-in-patient-centered-outcomes-research
#16
Michele P Dyson, Kassi Shave, Ricardo M Fernandes, Shannon D Scott, Lisa Hartling
BACKGROUND: With the rapid growth of technology and its improved accessibility globally, social media is gaining an increasingly important role in health care. Patients are frequently engaging with social media to access information, share content, and interact with others in online health communities. However, the use of social media as a stakeholder engagement strategy has been minimally explored, and effective methods for involving participants in research on the identification of patient-centered outcomes remain unknown...
March 16, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28302059/correspondence-of-d-melanogaster-and-c-elegans-developmental-stages-revealed-by-alternative-splicing-characteristics-of-conserved-exons
#17
Ruiqi Gao, Jingyi Jessica Li
BACKGROUND: We report a statistical study to find correspondence of D. melanogaster and C. elegans developmental stages based on alternative splicing (AS) characteristics of conserved cassette exons using modENCODE RNA-seq data. We identify "stage-associated exons" to capture the AS characteristics of each stage and use these exons to map pairwise stages within and between the two species by an overlap test. RESULTS: Within fly and worm, adjacent developmental stages are mapped to each other, i...
March 16, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28301498/knowledge-attitudes-and-practices-kap-relating-to-brucellosis-in-smallholder-dairy-farmers-in-two-provinces-in-pakistan
#18
Shumaila Arif, Peter C Thomson, Marta Hernandez-Jover, David M McGill, Hassan Mahmood Warriach, Jane Heller
The present study aimed to assess the extent of knowledge and understanding of brucellosis in smallholder dairy farmers and identify practices at the farm and household level that might pose a risk for humans contracting brucellosis. Between February and June 2015 a cross-sectional study was conducted among smallholder farms (n = 420) in five districts of Punjab and two districts of Sindh province. Farmers were interviewed using a questionnaire to obtain information on farmers' knowledge about brucellosis and the potential risks for contracting the disease that are present for dairy farmers and their families...
2017: PloS One
https://www.readbyqxmd.com/read/28300994/the-choking-game-a-new-craze-among-brazilian-children-and-young-people-psychophysiological-behavioral-and-epidemiological-characteristics-of-asphyxial-games
#19
Juliana Guilheri, Anne Andronikof, Latife Yazigi
The 'choking game' is a risk-taking behavior that has spread quickly among children and young people, causing dependence, accidents and even death, including in Brazil. These activities are performed in order to experience fleeting euphoric sensations, attracting numerous participants through the thousands of videos posted on YouTube. The problem of 'asphyxial games' can be observed in the Brazilian digital media, although there is a lack of scientific studies. Through a systematic review of the literature and complementary material, this paper aims to address the 'asphyxial games', warning about the psychophysiological and behavioral effects of these practices, while also presenting international epidemiological data...
March 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28300976/primary-health-care-reform-in-the-cities-of-lisbon-and-rio-de-janeiro-context-strategies-results-learning-and-challenges
#20
Daniel Soranz, Luís Augusto Coelho Pisco
On the 30th anniversary of Alma-Ata, the World Health Organization published in 2008 the "Primary Health Care Now More Than Ever" Report, calling on all governments to reflect on the need to reflect on four sets of reforms. These included: (i) universal coverage reforms; (ii) service delivery reforms; (iii) public policies reforms that would ensure healthier communities; and (iv) leadership reforms. In this context, in the period 2005-2016, the cities of Rio de Janeiro and Lisbon developed a profound primary healthcare reform, and did so by sharing many of the solutions based on the best internationally recognized organizational practices...
March 2017: Ciência & Saúde Coletiva
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