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https://www.readbyqxmd.com/read/29786807/-pharmacotherapy-of-epilepsy
#1
Torbjörn Tomson, Olof Rask
Pharmacotherapy of epilepsy is usually initiated after two or more unprovoked seizures, a decision that should be made after assessment of the individual risk of further seizures. Antiepileptic drugs (AEDs) are selected based on documented efficacy for the type of seizures, the epilepsy and possible epilepsy syndrome of the patient, taking potential adverse effects and comorbidity into account. For many AEDs, the mechanisms of action are incompletely understood. More than half of patients with newly diagnosed epilepsy achieve sustained seizure freedom with their first or second drug trials...
May 21, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29785719/children-s-experiences-and-expectations-of-kidney-transplantation-a-qualitative-interview-study
#2
Rachael C Walker, Derisha Naicker, Tonya Kara, Suetonia C Palmer
RATIONALE AND OBJECTIVE: Kidney transplantation offers improved quality of life and life expectancy compared with dialysis for children. This study aims to understand the experiences and expectations of children during the kidney transplantation process to inform clinical care. STUDY DESIGN: Face-to-face, semi-structured interviews. SETTING AND PARTICIPANTS: We interviewed 13 children and adolescents aged between 7 and 17 years old in New Zealand who had received a kidney transplantation...
May 21, 2018: Nephrology
https://www.readbyqxmd.com/read/29785065/relation-between-coping-and-posttrauma-cognitions-on-ptsd-in-a-combat-trauma-population
#3
Christina M Sheerin, Nadia Chowdhury, Mackenzie J Lind, Erin D Kurtz, Lance M Rappaport, Erin C Berenz, Ruth C Brown, Treven Pickett, Scott D McDonald, Carla Kmett Danielson, Ananda B Amstadter
Individual differences in cognitive processes and coping behaviors play a role in the development and maintenance of posttraumatic stress disorder (PTSD). Given the large numbers of combat-exposed service members returning from the Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) conflicts, exploring individual differences in cognitive-affective processes is important for informing our understanding of PTSD etiology and early intervention in military samples. The present study examined the unique main and interactive effects of negative posttrauma cognitions (i...
2018: Military Psychology
https://www.readbyqxmd.com/read/29784458/efficacy-of-antiepileptic-drugs-in-the-adjunctive-treatment-of-refractory-partial-onset-seizures-meta-analysis-of-pivotal-trials
#4
Jeremy Slater, Steve Chung, Lynn Huynh, Mei Sheng Duh, Brian Gorin, Carolyn McMicken, Adam Ziemann, Jouko Isojarvi
OBJECTIVE: In the absence of randomized clinical trials (RCTs) assessing the relative efficacy of antiepileptic drugs (AEDs), meta-analyses are useful resources for informing treatment choices. This meta-analysis assesses the relative efficacy and tolerability of AEDs for adjunctive treatment of refractory partial onset seizures (POS). METHODS: A systematic literature review was conducted to identify pivotal AED trials serving as the basis for US Food and Drug Administration (FDA) approval...
July 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29777674/an-approach-for-brain-controlled-prostheses-based-on-scene-graph-steady-state-visual-evoked-potentials
#5
Rui Li, Xiaodong Zhang, Hanzhe Li, Liming Zhang, Zhufeng Lu, Jiangcheng Chen
Brain control technology can restore communication between the brain and a prosthesis, and choosing a Brain-Computer Interface (BCI) paradigm to evoke electroencephalogram (EEG) signals is an essential step for developing this technology. In this paper, the Scene Graph paradigm used for controlling prostheses was proposed; this paradigm is based on Steady-State Visual Evoked Potentials (SSVEPs) regarding the Scene Graph of a subject's intention. A mathematic model was built to predict SSVEPs evoked by the proposed paradigm and a sinusoidal stimulation method was used to present the Scene Graph stimulus to elicit SSVEPs from subjects...
May 16, 2018: Brain Research
https://www.readbyqxmd.com/read/29777373/safety-and-feasibility-of-pulmonary-artery-pressure-guided-heart-failure-therapy-rationale-and-design-of-the-prospective-cardiomems-monitoring-study-for-heart-failure-mems-hf
#6
Christiane E Angermann, Birgit Assmus, Stefan D Anker, Johannes Brachmann, Georg Ertl, Friedrich Köhler, Stephan Rosenkranz, Carsten Tschöpe, Philip B Adamson, Michael Böhm
BACKGROUND: Wireless monitoring of pulmonary artery (PA) pressures with the CardioMEMS HF™ system is indicated in patients with New York Heart Association (NYHA) class III heart failure (HF). Randomized and observational trials have shown a reduction in HF-related hospitalizations and improved quality of life in patients using this device in the United States. OBJECTIVE: MEMS-HF is a prospective, non-randomized, open-label, multicenter study to characterize safety and feasibility of using remote PA pressure monitoring in a real-world setting in Germany, The Netherlands and Ireland...
May 19, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29775182/optically-dark-excitonic-states-mediated-exciton-and-biexciton-valley-dynamics-in-monolayer-wse-sub-2-sub
#7
Minghua Zhang, Jiyong Fu, A C Dias, Fanyao Qu
We present a theory to address the photoluminescence (PL) intensity and valley polarization (VP) dynamics in monolayer WSe$_2$, under the impact of excitonic dark states of both excitons and biexcitons. We find that the PL intensity of all excitonic channels including intravalley exciton (X$_{\rm b}$), intravalley biexciton (XX$_{\rm k,k}$) and intervalley biexciton (XX$_{\rm k,k^\prime}$) in particular for the {XX$_{\rm k,k}$} PL is enhanced by laser excitation fluence. In addition, our results indicate the anomalous temperature dependence of PL, i...
May 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29772961/contrasts-in-older-persons-experiences-and-significant-others-perceptions-of-existential-loneliness
#8
Helena Larsson, Anna-Karin Edberg, Ingrid Bolmsjö, Margareta Rämgård
BACKGROUND: As frail older people might have difficulties in expressing themselves, their needs are often interpreted by others, for example, by significant others, whose information health care staff often have to rely on. This, in turn, can put health care staff in ethically difficult situations, where they have to choose between alternative courses of action. One aspect that might be especially difficult to express is that of existential loneliness. We have only sparse knowledge about whether, and in what way, the views of frail older persons and their significant others concerning existential loneliness are in concordance...
January 1, 2018: Nursing Ethics
https://www.readbyqxmd.com/read/29765040/dynamics-of-a-qubit-while-simultaneously-monitoring-its-relaxation-and-dephasing
#9
Q Ficheux, S Jezouin, Z Leghtas, B Huard
Decoherence originates from the leakage of quantum information into external degrees of freedom. For a qubit, the two main decoherence channels are relaxation and dephasing. Here, we report an experiment on a superconducting qubit where we retrieve part of the lost information in both of these channels. We demonstrate that raw averaging the corresponding measurement records provides a full quantum tomography of the qubit state where all three components of the effective spin-1/2 are simultaneously measured...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29762920/outcomes-of-a-new-generation-stentless-aortic-valve-a-single-center-experience-with-251-consecutive-implants
#10
Guglielmo Stefanelli, Fabrizio Pirro, Giuseppe Danniballe, Alina Olaru, Marco Meli, Luca Weltert
BACKGROUND: The study aim was to investigate the hemodynamic behavior over time and ease of implant and durability of the Sorin Pericarbon Freedom (SPF)® stentless pericardial aortic xenograft. METHODS: Between March 2003 and April 2010, a total of 251 consecutive, non-selected patients (mean age 70.1 years; range: 17-89 years; 17.1% aged >80 years) received a SPF bioprosthesis as an aortic valve substitute at the authors' institution. All implantations were performed by a single surgeon using a classical, double-line, subcoronary implant technique...
September 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29760394/controlling-evanescent-waves-using-silicon-photonic-all-dielectric-metamaterials-for-dense-integration
#11
Saman Jahani, Sangsik Kim, Jonathan Atkinson, Justin C Wirth, Farid Kalhor, Abdullah Al Noman, Ward D Newman, Prashant Shekhar, Kyunghun Han, Vien Van, Raymond G DeCorby, Lukas Chrostowski, Minghao Qi, Zubin Jacob
Ultra-compact, densely integrated optical components manufactured on a CMOS-foundry platform are highly desirable for optical information processing and electronic-photonic co-integration. However, the large spatial extent of evanescent waves arising from nanoscale confinement, ubiquitous in silicon photonic devices, causes significant cross-talk and scattering loss. Here, we demonstrate that anisotropic all-dielectric metamaterials open a new degree of freedom in total internal reflection to shorten the decay length of evanescent waves...
May 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29758767/neural-network-approach-to-time-dependent-dividing-surfaces-in-classical-reaction-dynamics
#12
Philippe Schraft, Andrej Junginger, Matthias Feldmaier, Robin Bardakcioglu, Jörg Main, Günter Wunner, Rigoberto Hernandez
In a dynamical system, the transition between reactants and products is typically mediated by an energy barrier whose properties determine the corresponding pathways and rates. The latter is the flux through a dividing surface (DS) between the two corresponding regions, and it is exact only if it is free of recrossings. For time-independent barriers, the DS can be attached to the top of the corresponding saddle point of the potential energy surface, and in time-dependent systems, the DS is a moving object. The precise determination of these direct reaction rates, e...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29758590/interobserver-variation-in-cd30-immunohistochemistry-interpretation-consequences-for-patient-selection-for-targeted-treatment
#13
Lianne Koens, Peter M van de Ven, Nathalie J Hijmering, Marie José Kersten, Arjan Diepstra, Martine Chamuleau, Daphne de Jong
CD30 immunohistochemistry (IHC) in malignant lymphoma is used for selection of patients in clinical trials using brentuximab vedotin, an antibody drug-conjugate targeting the CD30 molecule. For reliable implementation in daily practice and meaningful selection of patients for clinical trials, information on technical variation and interobserver reproducibility of CD30 IHC staining is required. We conducted a 3-round reproducibility assessment of CD30 scoring for categorized frequency and intensity, including a technical validation, a "live polling" pre- and post-instruction scoring round, and a web-based round including individual scoring with additional IHC information to mimic daily diagnostic practice...
May 14, 2018: Histopathology
https://www.readbyqxmd.com/read/29756795/-preparatory-power-posing-affects-nonverbal-presence-and-job-interview-performance-correction-to-cuddy-et-al-2015
#14
(no author information available yet)
Reports an error in "Preparatory power posing affects nonverbal presence and job interview performance" by Amy J. C. Cuddy, Caroline A. Wilmuth, Andy J. Yap and Dana R. Carney ( Journal of Applied Psychology , 2015[Jul], Vol 100[4], 1286-1295). In the article, the degrees of freedom associated with the three F-tests noted on pages 1289 and 1290 should be 1 and 59 (and not 1 and 60, as previously reported). Also, on p. 1290, in the first sentence under the "Mediation" heading, it should be noted that the dependent variables were regressed onto the mediators, and not the other way around...
May 2018: Journal of Applied Psychology
https://www.readbyqxmd.com/read/29747241/stiripentol-add-on-therapy-for-focal-refractory-epilepsy
#15
REVIEW
Francesco Brigo, Stanley C Igwe, Nicola Luigi Bragazzi
BACKGROUND: This is an updated version of the Cochrane review last published in 2015 (Issue 10). For nearly 30% of people with epilepsy, seizures are not controlled by current treatments. Stiripentol is a new antiepileptic drug (AED) that was developed in France and was approved by the European Medicines Agency (EMA) in 2007 for the treatment of Dravet syndrome as an adjunctive therapy with valproate and clobazam, with promising effects. OBJECTIVES: To evaluate the efficacy and tolerability of stiripentol as add-on treatment for people with focal refractory epilepsy who are taking AEDs...
May 10, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29738263/which-social-values-are-considered-in-iranian-health-system
#16
Arash Rashidian, Mohammad Arab, Mohammadreza Vaez Mahdavi, Koimars Ashtarian, Hakimeh Mostafavi
BACKGROUND: Health systems have a set of limited resources for meeting the needs of communities. Health priority setting based on criteria and values is inevitable in such situation. This paper aims to identify the social values that are considered in Iranian health system. METHODS: This qualitative study was conducted in 3 steps including collecting national documents and literature review, interviewing key informants, and a 2 round Delphi. Interviews and documents were analyzed through thematic framework analysis...
May 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29733410/perioperative-multimodal-evaluation-and-surgical-tactics-of-tumor-related-epilepsy-2-dimensional-operative-video
#17
Chengxin Ma, Rui Feng, N U Farrukh Hameed, Jie Zhang, Dongxiao Zhuang, Jinsong Wu
Treatment of tumor-related epilepsy (TRE), especially for tumors near critical areas, requires surgeons to strike a balance between the epileptic benefit and functional outcome after surgery. Here, we present a case in which multimodal evaluation facilitated the achievement of such surgical balance. Informed patient consent was obtained. A 17-yr-old female presented with seizure attacks for 2 yr. Magnetic resonance imaging (MRI) revealed a right parietal mass lesion with hypointense signal on T1W imaging, hyperintense signal on T2W imaging, and homogeneous enhancement...
May 4, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29730621/how-a-deliberative-approach-includes-women-in-the-decisions-of-screening-mammography-a-citizens-jury-feasibility-study-in-andalusia-spain
#18
José M Baena-Cañada, Violeta Luque-Ribelles, Alicia Quílez-Cutillas, Petra Rosado-Varela, Encarnación Benítez-Rodríguez, Soledad Márquez-Calderón, Juan Manuel Rivera-Bautista
OBJECTIVES: To verify whether a citizens' jury study is feasible to the Andalusian population and to know if women, when better informed, are able to answer the research question of whether the Andalusian Public Health System must continue offering screening mammography to women aged 50-69. The reasons for the pertinent decision and recommendations to the political authorities will be stated. DESIGN: Qualitative research study with the methodology of citizens' jury...
May 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29726492/inverse-source-in-the-near-field-the-case-of-a-strip-current
#19
Raffaele Solimene, Maria Antonia Maisto, Rocco Pierri
In this paper, we consider an inverse source problem in the near zone for a prototype configuration where the field radiated by a bounded strip magnetic current is observed over a rectilinear and parallel (to the source) observation domain. The study focuses on how the achievable performance depends on the configuration's geometric parameters and the noise. In particular, we succeed in working out an approximation for the singular spectrum of the pertinent radiation operator that allows us to obtain analytical estimations for the resolution, the number of degrees of freedom, and the information content...
May 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29723328/paroxysmal-atrial-fibrillation-in-females-understanding-gender-diferences
#20
Gabriel Odozynski, Alexander Romeno Janner Dal Forno, Andrei Lewandowski, Hélcio Garcia Nascimento, André d'Avila
BACKGROUND: The catheter ablation of atrial fibrillation (AF) is performed less frequently in women. In addition, there is divergent information in the literature regarding the effectiveness and safety for the ablative procedure to females. OBJECTIVES: The objective of this study was to compare the clinical characteristics and outcomes in men and women undergoing paroxysmal atrial fibrillation (PAF) ablation. METHODS: Cohort study of patients undergoing first-ever PAF catheter ablation procedure refractory to antiarrhythmic drugs...
May 3, 2018: Arquivos Brasileiros de Cardiologia
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