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https://www.readbyqxmd.com/read/28911210/a20-an-essential-component-of-the-ubiquitin-editing-protein-complex-is-a-negative-regulator-of-inflammation-in-human-myometrium-and-foetal-membranes
#1
Martha Lappas
STUDY QUESTION: Does A20 regulate mediators involved in the terminal processes of human labour in primary myometrial and amnion cells? SUMMARY ANSWER: A20 is a nuclear factor-kappa B (NF-κB) responsive gene that acts as a negative regulator of NF-κB-induced expression of pro-labour mediators. WHAT IS KNOWN ALREADY: Inflammation is commonly implicated in spontaneous preterm birth and the processes involved in rupture of foetal membranes and uterine contractions...
September 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28881256/structural-brain-correlates-of-resilience-to-traumatic-stress-in-dutch-police-officers
#2
Steven J A van der Werff, Bernet M Elzinga, Annika S Smit, Nic J A van der Wee
OBJECTIVE: Neurobiological research has traditionally focused on vulnerability rather than on resilience to severe stress. So far, only a few neuroimaging studies examining resilience have used designs that allow disentangling of the neural correlates of resilience from those related to psychopathology or trauma-exposure. The aim of this study was to identify structural brain correlates of resilience, and their correlations with behavioral measures. METHOD: MRI scanning was performed in three groups of police officers: (1) a resilient group (N=29; trauma-exposed, no psychopathology), (2) a vulnerable group (N=33; trauma-exposed, psychopathology), and (3) a control group (N=19; no trauma, no psychopathology)...
August 26, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28874119/automated-segmentation-of-cerebral-deep-gray-matter-from-mri-scans-effect-of-field-strength-on-sensitivity-and-reliability
#3
Renxin Chu, Shelley Hurwitz, Shahamat Tauhid, Rohit Bakshi
BACKGROUND: The cerebral subcortical deep gray matter nuclei (DGM) are a common, early, and clinically-relevant site of atrophy in multiple sclerosis (MS). Robust and reliable DGM segmentation could prove useful to evaluate putative neuroprotective MS therapies. The objective of the study was to compare the sensitivity and reliability of DGM volumes obtained from 1.5T vs. 3T MRI. METHODS: Fourteen patients with MS [age (mean, range) 50.2 (32.0-60.8) years, disease duration 18...
September 5, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28870884/a-combined-vbm-and-dti-study-of-schizophrenia-bilateral-decreased-insula-volume-and-cerebral-white-matter-disintegrity-corresponding-to-subinsular-white-matter-projections-unlinked-to-clinical-symptomatology
#4
Aslıhan Onay, Hale Yapıcı Eser, Çiğdem Ulaşoğlu Yıldız, Selçuk Aslan, Erhan Turgut Talı
PURPOSE: Grey matter and white matter changes within the brain are well defined in schizophrenia. However, most studies focused on either grey matter changes or white matter integrity separately; only in limited number of studies these changes were interpreted in the same frame. In addition, the relationship of these findings with clinical variables is not clearly established. Here, we aimed to investigate the grey matter and white matter changes in schizophrenia patients and exhibit the relation of these imaging findings with clinical variables...
September 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28845112/safety-and-utility-of-endoscopic-ultrasound-guided-fine-needle-aspiration-of-focal-splenic-lesions-a-retrospective-analysis
#5
Surinder S Rana, Vishal Sharma, Ravi Sharma, Radhika Srinivasan, Rajesh Gupta
BACKGROUND: Fine-needle aspiration (FNA) of focal splenic lesions (FSL) is usually done under ultrasound (US) or computed tomography guidance. Endoscopic US (EUS), because of its ability to provide high-resolution images, can be used for aspirating FSL. We studied the safety and efficacy of EUS-guided FNA of FSL. METHODS: We performed a retrospective analysis of patients with FSL undergoing EUS-guided FNA over the last six years. RESULTS: EUS-guided FNA was performed in 16 patients (age: 28-43 years; male: 11)...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28844021/tlr2-tlr3-and-tlr5-regulation-of-pro-inflammatory-and-pro-labour-mediators-in-human-primary-myometrial-cells
#6
Ratana Lim, Gillian Barker, Martha Lappas
Preterm birth continues to be a significant global health care issue, due to our lack of understanding of the mechanisms that drive human labour and delivery. Toll-like receptors (TLRs) are essential in triggering an inflammatory response in human gestational tissues, leading to the production of pro-inflammatory and pro-labour mediators, and thus preterm birth. The aims of this study were to determine whether the adaptor molecules associated with TLR2, TLR3 and TLR5 signalling are involved in human myometrium...
August 24, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28842277/olfactory-discrimination-and-memory-deficits-in-the-flinders-sensitive-line-rodent-model-of-depression
#7
A Cook, L-M Pfeiffer, S Thiele, V A Coenen, M D Döbrössy
Major Depressive Disorder (MDD) is a heterogeneous psychiatric disorder with broad symptomatic manifestations. The current study examined, for the first time, olfactory memory and discrimination in the Flinders Sensitive Line (FSL) rodent model of depression. Male FSL rats and controls were trained on an Olfactory Discrimination (OD) and a Social Interaction (SI) test. On the OD test, the FSL and controls performed similarly at the shortest inter-trial interval (5min), however, with extended delay of 30min, the FSLs had a recall and odour discrimination deficit...
October 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28828546/altered-resting-state-connectivity-in-right-side-frontoparietal-network-in-primary-insomnia-patients
#8
Shumei Li, Junzhang Tian, Meng Li, Tianyue Wang, Chulan Lin, Yi Yin, Luxian Zeng, Cheng Li, Guihua Jiang
OBJECTIVE: This study investigated alterations of resting-state networks (RSNs) in primary insomnia patients as well as relationships between these changes and clinical features. METHODS: Fifty-nine primary insomnia patients and 53 healthy control subjects underwent a resting-state fMRI scan (rs-fMRI). Ten RSNs were identified using independent component analysis of rs-fMRI data. To assess significant differences between the two groups, voxel-wise analysis of ten RSNs was conducted using dual regression with FSL randomised non-parametric permutation testing and a threshold-free cluster enhanced technique to control for multiple comparisons...
August 21, 2017: European Radiology
https://www.readbyqxmd.com/read/28819456/therapeutic-effect-of-astroglia-like-mesenchymal-stem-cells-expressing-glutamate-transporter-in-a-genetic-rat-model-of-depression
#9
Amit Shwartz, Oshra Betzer, Noam Kronfeld, Gila Kazimirsky, Simona Cazacu, Susan Finniss, Hae Kyung Lee, Menachem Motiei, Shani Yael Dagan, Rachela Popovtzer, Chaya Brodie, Gal Yadid
Recent studies have proposed that abnormal glutamatergic neurotransmission and glial pathology play an important role in the etiology and manifestation of depression. It was postulated that restoration of normal glutamatergic transmission, by enhancing glutamate uptake, may have a beneficial effect on depression. We examined this hypothesis using unique human glial-like mesenchymal stem cells (MSCs), which in addition to inherent properties of migration to regions of injury and secretion of neurotrophic factors, were differentiated to express high levels of functional glutamate transporters (excitatory amino acid transporters; EAAT)...
2017: Theranostics
https://www.readbyqxmd.com/read/28794970/agreement-of-msmetrix-with-established-methods-for-measuring-cross-sectional-and-longitudinal-brain-atrophy
#10
Martijn D Steenwijk, Houshang Amiri, Menno M Schoonheim, Alexandra de Sitter, Frederik Barkhof, Petra J W Pouwels, Hugo Vrenken
INTRODUCTION: Despite the recognized importance of atrophy in multiple sclerosis (MS), methods for its quantification have been mostly restricted to the research domain. Recently, a CE labelled and FDA approved MS-specific atrophy quantification method, MSmetrix, has become commercially available. Here we perform a validation of MSmetrix against established methods in simulated and in vivo MRI data. METHODS: Whole-brain and gray matter (GM) volume were measured with the cross-sectional pipeline of MSmetrix and compared to the outcomes of FreeSurfer (cross-sectional pipeline), SIENAX and SPM...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28783513/platelet-toll-like-receptor-tlr-expression-and-tlr-mediated-platelet-activation-in-acute-myocardial-infarction
#11
Kathryn E Hally, Anne C La Flamme, Peter D Larsen, Scott A Harding
Both platelets and Toll-like receptors (TLRs) contribute to acute myocardial infarction (AMI). Platelet activation can occur post-AMI and despite treatment with anti-platelet therapy. TLRs may represent an alternative platelet activation pathway, although the role of platelet-TLRs in AMI is poorly characterized. The aim of this study was to examine platelet-TLR expression and TLR-mediated platelet activation in healthy and AMI subjects. Here, we report that platelets from AMI patients exhibit upregulation of some, but not other, TLRs...
August 1, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28777748/fully-automatic-mri-based-hippocampus-volumetry-using-fsl-first-intra-scanner-test-retest-stability-inter-field-strength-variability-and-performance-as-enrichment-biomarker-for-clinical-trials-using-prodromal-target-populations-at-risk-for-alzheimer-s-disease
#12
Enrica Cavedo, Per Suppa, Catharina Lange, Roland Opfer, Simone Lista, Samantha Galluzzi, Adam J Schwarz, Lothar Spies, Ralph Buchert, Harald Hampel
BACKGROUND: MRI-based hippocampus volume is a core clinical biomarker for identification of Alzheimer's disease (AD). OBJECTIVE: To assess robustness of automatic hippocampus volumetry with the freely available FSL-FIRST software with respect to short-term repeat and across field strength imaging. FSL-FIRST hippocampus volume (FIRST-HV) was also evaluated as enrichment biomarker for mild cognitive impairment (MCI) trials. METHODS: Robustness of FIRST-HV was assessed in 51 healthy controls (HC), 74 MCI subjects, and 28 patients with AD dementia from ADNI1, each with two pairs of back-to-back scans, one at 1...
July 29, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28734178/subcortical-surface-shape-in-youth-at-familial-high-risk-for-schizophrenia
#13
Kathryn Hill, Nicolas Bolo, Suraj Sarvode Mothi, Paulo Lizano, Synthia Guimond, Neeraj Tandon, Elena Molokotos, Matcheri Keshavan
Abnormalities in the subcortical brain regions that support cognitive functions have been reported in schizophrenia. Relatives of those with schizophrenia often present with psychosis-like traits (schizotypy) and similar cognition as those with schizophrenia. To evaluate the relationships between subcortical structure, schizotypy, and cognitive function, we assessed shape and volume of the hippocampus, amygdala and thalamus in untreated youth at familial high risk for schizophrenia (HRSZ). The sample consisted of 66 HRSZ and 69 age-matched healthy controls (HC)...
July 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28716114/visumax-femtolasik-versus-moria-m2-microkeratome-in-mild-to-moderate-myopia-efficacy-safety-predictability-aberrometric-changes-and-flap-thickness-predictability
#14
Magda A Torky, Yousif A Al Zafiri, Abeer M Khattab, Rania K Farag, Eman A Awad
INTRODUCTION: This is an interventional prospective clinical study which was conducted to evaluate the efficacy, safety, predictability, ocular aberrations, and flap thickness predictability of Visumax femtosecond laser (FSL) compared to Moria M2 microkeratome (MK) in mild to moderate myopia. METHODS: This study included 60 eyes who were divided into two groups. Thirty eyes in group (I) in which the flap was created with Visumax FSL, while in group II (30 eyes) the Moria M2 MK was used...
July 17, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28701991/an-arterial-spin-labeling-mri-perfusion-study-of-migraine-without-aura-attacks
#15
Raquel Gil-Gouveia, Joana Pinto, Patricia Figueiredo, Pedro Ferro Vilela, Isabel Pavão Martins
BACKGROUND: Studies of brain perfusion during migraine without aura attacks have inconsistent results. METHODS: Arterial spin labeling MRI, a non-invasive quantitative perfusion technique, was used to prospectively study a spontaneous untreated migraine without aura attack and a headache-free period. Image analysis used FSL and MATLAB software; Group analysis used permutation methods for perfusion differences between sessions. RESULTS: Thirteen women (age 35...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28667248/suppression-of-%C3%AE-v%C3%AE-6-integrin-expression-by-polymicrobial-oral-biofilms-in-gingival-epithelial-cells
#16
Jiarui Bi, Leeni Koivisto, Aihui Pang, Ming Li, Guoqiao Jiang, Saljae Aurora, Zhejun Wang, Gethin R Owen, Jiayin Dai, Ya Shen, Daniel Grenier, Markus Haapasalo, Lari Häkkinen, Hannu Larjava
Periodontal diseases manifest by the formation of deep pockets between the gingiva and teeth where multispecies bacterial biofilms flourish, causing inflammation and bone loss. Epithelial cell receptor αvβ6 integrin that regulates inflammation by activating the anti-inflammatory cytokine transforming growth factor-β1, is highly expressed in healthy junctional epithelium that connects the gingiva to the tooth enamel. However, its expression is attenuated in human periodontal disease. Moreover, Itgb6 (-/-) mice display increased periodontal inflammation compared to wild-type mice...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28649200/cognitive-variability-during-middle-age-possible-association-with-neurodegeneration-and-cognitive-reserve
#17
Daniel Ferreira, Alejandra Machado, Yaiza Molina, Antonieta Nieto, Rut Correia, Eric Westman, José Barroso
Objective: Increased variability in cognition with age has been argued as an indication of pathological processes. Focusing on early detection of neurodegenerative disorders, we investigated variability in cognition in healthy middle-aged adults. In order to understand possible determinants of this variability, we also investigated associations with cognitive reserve, neuroimaging markers, subjective memory complaints, depressive symptomatology, and gender. Method: Thirty-one 50 ± 2 years old individuals were investigated as target group and deviation was studied in comparison to a reference younger group of 30 individuals 40 ± 2 years old...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28648655/outcomes-of-foam-sclerotherapy-plus-ligation-versus-foam-sclerotherapy-alone-for-venous-ulcers-in-lower-extremities
#18
Xin Li, Lin Fan, Shiyan Ren, Xianlun Li
BACKGROUND: Foam sclerotherapy (FS) is a safe and effective approach for managing patients with varicose veins and venous ulcers in lower extremities. But, recanalization of the ablated varicose veins and phlebitis are common postoperative complications that jeopardize its clinical effects. We hypothesize that ligation of the ablated varicose veins after FS will improve the outcomes of patients with varicose veins and venous ulcer. This study was aimed to evaluate the clinical efficacy of ligation after FS in comparison with FS alone for the management of patients with varicose veins and venous ulcers in lower extremities...
June 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28647020/reprint-of-a-comprehensive-review-of-group-level-model-performance-in-the-presence-of-heteroscedasticity-can-a-single-model-control-type-i-errors-in-the-presence-of-outliers
#19
Jeanette A Mumford
Even after thorough preprocessing and a careful time series analysis of functional magnetic resonance imaging (fMRI) data, artifact and other issues can lead to violations of the assumption that the variance is constant across subjects in the group level model. This is especially concerning when modeling a continuous covariate at the group level, as the slope is easily biased by outliers. Various models have been proposed to deal with outliers including models that use the first level variance or that use the group level residual magnitude to differentially weight subjects...
July 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/28626291/machine-learning-in-a-graph-framework-for-subcortical-segmentation
#20
Zhihui Guo, Satyananda Kashyap, Milan Sonka, Ipek Oguz
Automated and reliable segmentation of subcortical structures from human brain magnetic resonance images is of great importance for volumetric and shape analyses in quantitative neuroimaging studies. However, poor boundary contrast and variable shape of these structures make the automated segmentation a tough task. We propose a 3D graph-based machine learning method, called LOGISMOS-RF, to segment the caudate and the putamen from brain MRI scans in a robust and accurate way. An atlas-based tissue classification and bias-field correction method is applied to the images to generate an initial segmentation for each structure...
February 11, 2017: Proceedings of SPIE
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