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https://www.readbyqxmd.com/read/29770530/accurate-nonlinear-mapping-between-mni-volumetric-and-freesurfer-surface-coordinate-systems
#1
Jianxiao Wu, Gia H Ngo, Douglas Greve, Jingwei Li, Tong He, Bruce Fischl, Simon B Eickhoff, B T Thomas Yeo
The results of most neuroimaging studies are reported in volumetric (e.g., MNI152) or surface (e.g., fsaverage) coordinate systems. Accurate mappings between volumetric and surface coordinate systems can facilitate many applications, such as projecting fMRI group analyses from MNI152/Colin27 to fsaverage for visualization or projecting resting-state fMRI parcellations from fsaverage to MNI152/Colin27 for volumetric analysis of new data. However, there has been surprisingly little research on this topic. Here, we evaluated three approaches for mapping data between MNI152/Colin27 and fsaverage coordinate systems by simulating the above applications: projection of group-average data from MNI152/Colin27 to fsaverage and projection of fsaverage parcellations to MNI152/Colin27...
May 16, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29751216/pellino-1-is-a-novel-regulator-of-tnf-and-tlr-signalling-in-human-myometrial-and-amnion-cells
#2
Ratana Lim, Gillian Barker, Martha Lappas
Preterm birth is the primary cause of neonatal deaths and morbidities. Pathological processes causally linked to preterm birth are inflammation and infection. Pellino-1 (Peli1) has previously been found to regulate the inflammatory response in non-gestational tissues in response to toll-like receptor (TLR) ligands and pro-inflammatory cytokines. The aims of this study were to determine the effect of labor on Peli1 expression in myometrium and fetal membranes, and the effect of Peli1 silencing by siRNA (siPELI1) on the production of pro-inflammatory and pro-labor mediators...
April 14, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29743620/novel-polymer-free-everolimus-eluting-stent-fabricated-using-femtosecond-laser-improves-re-endothelialization-and-anti-inflammation
#3
In-Ho Bae, Myung Ho Jeong, Kyung Seob Lim, Dae Sung Park, Jae Won Shim, Jun-Kyu Park, Kwang Hwan Oh, Mi Rim Jin, Doo Sun Sim
The aim of this study was to fabricate a novel polymer-free everolimus-eluting stent with nanostructure using a femtosecond laser (FSL). The stent were coated with everolimus (EVL) using FSL and electrospinning processes. The surface was rendered hydrophobic, which negatively affected both platelet adhesion (82.1%) and smooth muscle cell response. Animal study was performed using a porcine coronary restenosis model. The study groups were divided into 1) bare metal stent (BMS), 2) poly(L-lactide) (PLA)-based EVL drug eluting stent (DES), 3) commercial EVL-eluting DES, and 4) FSL-EVL-DES...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29729389/what-do-results-from-coordinate-based-meta-analyses-tell-us
#4
Anton Albajes-Eizagirre, Joaquim Radua
Coordinate-based meta-analyses (CBMA) methods, such as Activation Likelihood Estimation (ALE) and Seed-based d Mapping (SDM), have become an invaluable tool for summarizing the findings of voxel-based neuroimaging studies. However, the progressive sophistication of these methods may have concealed two particularities of their statistical tests. Common univariate voxelwise tests (such as the t/z-tests used in SPM and FSL) detect voxels that activate, or voxels that show differences between groups. Conversely, the tests conducted in CBMA test for "spatial convergence" of findings, i...
May 2, 2018: NeuroImage
https://www.readbyqxmd.com/read/29714673/measurement-of-whole-brain-and-gray-matter-atrophy-in-multiple-sclerosis-assessment-with-mr-imaging
#5
Loredana Storelli, Maria A Rocca, Elisabetta Pagani, Wim Van Hecke, Mark A Horsfield, Nicola De Stefano, Alex Rovira, Jaume Sastre-Garriga, Jacqueline Palace, Diana Sima, Dirk Smeets, Massimo Filippi
Purpose To compare available methods for whole-brain and gray matter (GM) atrophy estimation in multiple sclerosis (MS) in terms of repeatability (same magnetic resonance [MR] imaging unit) and reproducibility (different system/field strength) for their potential clinical applications. Materials and Methods The softwares ANTs-v1.9, CIVET-v2.1, FSL-SIENAX/SIENA-5.0.1, Icometrix-MSmetrix-1.7, and SPM-v12 were compared. This retrospective study, performed between March 2015 and March 2017, collected data from (a) eight simulated MR images and longitudinal data (2 weeks) from 10 healthy control subjects to assess the cross-sectional and longitudinal accuracy of atrophy measures, (b) test-retest MR images in 29 patients with MS acquired within the same day at different imaging unit field strengths/manufacturers to evaluate precision, and (c) longitudinal data (1 year) in 24 patients with MS for the agreement between methods...
May 27, 2018: Radiology
https://www.readbyqxmd.com/read/29682880/activation-of-nlrp3-inflammasome-in-macrophages-by-mycoplasmal-lipoproteins-and-lipopeptides
#6
Ayumi Saeki, Masahiro Sugiyama, Akira Hasebe, Toshihiko Suzuki, Ken-Ichiro Shibata
The NLRP3 inflammasome, an intracellular sensor consisting of the NOD-like receptor family, pyrin domain containing 3 (NLRP3), the adaptor protein apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC), and procaspase-1, plays critical roles in host defense against microbial pathogens by inducing production of interleukin (IL)-1β and IL-18. Mycoplasma salivarium and Mycoplasma pneumoniae cells activated murine bone marrow-derived macrophages (BMMs) to induce production of IL-1α, IL-1β, and IL-18...
April 23, 2018: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/29682558/dream-is-involved-in-the-genesis-of-inflammation-induced-prolabour-mediators-in-human-myometrial-and-amnion-cells
#7
Priyanka Goradia, Ratana Lim, Martha Lappas
Preterm birth is the primary cause of perinatal morbidity and mortality worldwide. Inflammation induces a cascade of events leading to preterm birth by activating nuclear factor- κ B (NF- κ B). In nongestational tissues, downstream regulatory element antagonist modulator (DREAM) regulates NF- κ B activity. Our aims were to analyse DREAM expression in myometrium and fetal membranes obtained at term and preterm and to determine the effect of DREAM inhibition on prolabour mediators in primary myometrial and amnion cells...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29672584/fast-csf-mri-for-brain-segmentation-cross-validation-by-comparison-with-3d-t1-based-brain-segmentation-methods
#8
Lisa A van der Kleij, Jeroen de Bresser, Jeroen Hendrikse, Jeroen C W Siero, Esben T Petersen, Jill B De Vis
OBJECTIVE: In previous work we have developed a fast sequence that focusses on cerebrospinal fluid (CSF) based on the long T2 of CSF. By processing the data obtained with this CSF MRI sequence, brain parenchymal volume (BPV) and intracranial volume (ICV) can be automatically obtained. The aim of this study was to assess the precision of the BPV and ICV measurements of the CSF MRI sequence and to validate the CSF MRI sequence by comparison with 3D T1-based brain segmentation methods. MATERIALS AND METHODS: Ten healthy volunteers (2 females; median age 28 years) were scanned (3T MRI) twice with repositioning in between...
2018: PloS One
https://www.readbyqxmd.com/read/29650266/increased-sensorimotor-network-connectivity-associated-with-clozapine-eligibility-in-people-with-schizophrenia
#9
Carolyn Beth McNabb, Frederick Sundram, Ian Soosay, Robert R Kydd, Bruce Roy Russell
Schizophrenia is a heterogeneous disorder that exhibits variable responsiveness to treatment between individuals. Here we conducted a resting-state functional magnetic resonance imaging (rs-fMRI) study to determine whether resistance to first-line antipsychotics is reflected in resting-state connectivity. rs-fMRI data were collected from 15 people who had failed to respond to first-line antipsychotics (clozapine-eligible) and 10 first-line treatment responders (FLR). Image pre-processing and analysis were performed using FMRIB's software library (FSL)...
March 6, 2018: Psychiatry research. Neuroimaging
https://www.readbyqxmd.com/read/29599801/continuous-flash-glucose-monitoring-in-children-with-congenital-hyperinsulinism-first-report-on-accuracy-and-patient-experience
#10
Hussain Alsaffar, Lucy Turner, Zoe Yung, Mohammed Didi, Senthil Senniappan
Background: The factory calibrated FreeStyle Libre (FSL) flash glucose monitoring system has been recently introduced for use in patients with diabetes mellitus. There are no reports available regarding its use in patients with congenital hyperinsulinism (CHI). We have assessed the accuracy of FSL compared to the finger prick capillary blood glucose (CBG) over 2 weeks period in patients with CHI and evaluated the parents' experience of using FSL. Methods: Four hundred sixty-seven episodes of CBG along with corresponding swipe FSL readings were available from 11 children with CHI (0...
2018: International Journal of Pediatric Endocrinology
https://www.readbyqxmd.com/read/29578029/ubo-detector-a-cluster-based-fully-automated-pipeline-for-extracting-white-matter-hyperintensities
#11
Jiyang Jiang, Tao Liu, Wanlin Zhu, Rebecca Koncz, Hao Liu, Teresa Lee, Perminder S Sachdev, Wei Wen
We present 'UBO Detector', a cluster-based, fully automated pipeline for extracting and calculating variables for regions of white matter hyperintensities (WMH) (available for download at https://cheba.unsw.edu.au/group/neuroimaging-pipeline). It takes T1-weighted and fluid attenuated inversion recovery (FLAIR) scans as input, and SPM12 and FSL functions are utilised for pre-processing. The candidate clusters are then generated by FMRIB's Automated Segmentation Tool (FAST). A supervised machine learning algorithm, k-nearest neighbor (k-NN), is applied to determine whether the candidate clusters are WMH or non-WMH...
March 22, 2018: NeuroImage
https://www.readbyqxmd.com/read/29571075/elevated-body-mass-index-is-associated-with-reduced-white-matter-integrity-in-two-large-independent-cohorts
#12
Jonathan Repple, Nils Opel, Susanne Meinert, Ronny Redlich, Tim Hahn, Nils R Winter, Claas Kaehler, Daniel Emden, Ramona Leenings, Dominik Grotegerd, Dario Zaremba, Christian Bürger, Katharina Förster, Katharina Dohm, Verena Enneking, Elisabeth J Leehr, Joscha Böhnlein, Greta Karliczek, Walter Heindel, Harald Kugel, Jochen Bauer, Volker Arolt, Udo Dannlowski
Obesity has been associated with a variety of neurobiological alterations. Recent neuroimaging research has pointed to the relevance of brain structural and functional alterations in the development of obesity. However, while the role of gray matter atrophy in obesity has been evidenced in several well powered studies, large scale evidence for altered white matter integrity in obese subjects is still absent. With this study, we therefore aimed to investigate potential associations between white matter abnormalities and body mass index (BMI) in two large independent samples of healthy adults...
March 14, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29566450/segmentation-of-gray-matter-white-matter-and-csf-with-fluid-and-white-matter-suppression-using-mp2rage
#13
Yishi Wang, Yajie Wang, Zhe Zhang, Yuhui Xiong, Qiang Zhang, Chun Yuan, Hua Guo
BACKGROUND: MP2RAGE can generate uniform T1 -weighted images, which have been used for brain segmentation. However, there remain concerns about carrying out fast brain segmentation. PURPOSE: To propose an acquisition-based method for fast segmentation of gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) of healthy human brains with fluid and white matter suppression (FLAWS) using MP2RAGE. STUDY TYPE: Prospective. SUBJECTS: 12 volunteers (23-28 years, seven subjects; 51-62 years, five subjects)...
March 22, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29559931/brain-structures-associated-with-internet-addiction-tendency-in-adolescent-online-game-players
#14
Nannan Pan, Yongxin Yang, Xin Du, Xin Qi, Guijin Du, Yang Zhang, Xiaodong Li, Quan Zhang
With the development of the Internet, an increasing number of adolescents play online game excessively, which leads to adverse effects on individuals and society. Previous studies have demonstrated altered gray-matter volume (GMV) in individuals with Internet gaming disorder (IGD), but the relationship between the tendency to IGD and the GMV across whole brain is still unclear in adolescents. In the present study, anatomical imaging with high resolution was performed on 67 male adolescents who played online game; and Young's Internet addiction test (IAT) was conducted to test the tendency to IGD...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29550581/rapid-fully-automatic-segmentation-of-subcortical-brain-structures-by-shape-constrained-surface-adaptation
#15
Fabian Wenzel, Carsten Meyer, Thomas Stehle, Jochen Peters, Susanne Siemonsen, Christian Thaler, Lyubomir Zagorchev
This work presents a novel approach for the rapid segmentation of clinically relevant subcortical brain structures in T1-weighted MRI by utilizing a shape-constrained deformable surface model. In contrast to other approaches for segmenting brain structures, its design allows for parallel segmentation of individual brain structures within a flexible and robust hierarchical framework such that accurate adaptation and volume computation can be achieved within a minute of processing time. Furthermore, adaptation is driven by local and not global contrast, potentially relaxing requirements with respect to preprocessing steps such as bias-field correction...
May 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29549466/within-patient-fluctuation-of-brain-volume-estimates-from-short-term-repeated-mri-measurements-using-siena-fsl
#16
Roland Opfer, Ann-Christin Ostwaldt, Christine Walker-Egger, Praveena Manogaran, Maria Pia Sormani, Nicola De Stefano, Sven Schippling
BACKGROUND: Measurements of brain volume loss (BVL) in individual patients are currently discussed controversially. One concern is the impact of short-term biological noise, like hydration status. METHODS: Three publicly available reliability MRI datasets with scan intervals of days to weeks were used. An additional cohort of 60 early relapsing multiple sclerosis (MS) patients with MRI follow-ups was analyzed to test whether after 1 year pathological BVL is detectable in a relevant fraction of MS patients...
May 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29548850/a-comparison-of-publicly-available-linear-mri-stereotaxic-registration-techniques
#17
Mahsa Dadar, Vladimir S Fonov, D Louis Collins
INTRODUCTION: Linear registration to a standard space is one of the major steps in processing and analyzing magnetic resonance images (MRIs) of the brain. Here we present an overview of linear stereotaxic MRI registration and compare the performance of 5 publicly available and extensively used linear registration techniques in medical image analysis. METHODS: A set of 9693 T1-weighted MR images were obtained for testing from 4 datasets: ADNI, PREVENT-AD, PPMI, and HCP, two of which have multi-center and multi-scanner data and three of which have longitudinal data...
July 1, 2018: NeuroImage
https://www.readbyqxmd.com/read/29529408/functional-activation-during-a-cognitive-control-task-in-healthy-youth-specific-to-externalizing-or-internalizing-behaviors
#18
Katherine H Karlsgodt, Angelica A Bato, Toshikazu Ikuta, Bart D Peters, Pamela DeRosse, Philip R Szeszko, Anil K Malhotra
BACKGROUND: Externalizing behaviors are negative behaviors expressed outwardly, including rule breaking, aggression, and risk taking; internalizing behaviors are expressed inwardly, including depression, withdrawal, and anxiety. Such behavior can cause problems in early life and predict difficulties across the lifespan. There is evidence for a relationship between executive function and both externalizing and internalizing. However, although these behaviors occur along a spectrum, there is little neuroimaging research on this relationship in typically developing youth...
February 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29527503/the-potential-value-of-probabilistic-tractography-based-for-mr-guided-focused-ultrasound-thalamotomy-for-essential-tremor
#19
Evangelia Tsolaki, Angela Downes, William Speier, W Jeff Elias, Nader Pouratian
Magnetic Resonance-guided Focused UltraSound (MRgFUS) offers an incisionless approach to treat essential tremor (ET). Due to lack of evident internal anatomy on traditional structural imaging, indirect targeting must still be used to localize the lesion. Here, we investigate the potential predictive value of probabilistic tractography guided thalamic targeting by defining how tractography-defined targets, lesion size and location, and clinical outcomes interrelate. MR imaging and clinical outcomes from 12 ET patients that underwent MRgFUS thalamotomy in a pilot study at the University of Virginia were evaluated in this analysis...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29527477/removal-of-artifacts-from-resting-state-fmri-data-in-stroke
#20
Grigori Yourganov, Julius Fridriksson, Brielle Stark, Christopher Rorden
We examined the effect of lesion on the resting-state functional connectivity in chronic post-stroke patients. We found many instances of strong correlations in BOLD signal measured at different locations within the lesion, making it hard to distinguish from the connectivity between intact and strongly connected regions. Regression of the mean cerebro-spinal fluid signal did not alleviate this problem. The connectomes computed by exclusion of lesioned voxels were not good predictors of the behavioral measures...
2018: NeuroImage: Clinical
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