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https://www.readbyqxmd.com/read/29353341/field-of-view-normalization-in-multi-site-brain-mri
#1
Yangming Ou, Lilla Zöllei, Xiao Da, Kallirroi Retzepi, Shawn N Murphy, Elizabeth R Gerstner, Bruce R Rosen, P Ellen Grant, Jayashree Kalpathy-Cramer, Randy L Gollub
Multi-site brain MRI analysis is needed in big data neuroimaging studies, but challenging. The challenges lie in almost every analysis step including skull stripping. The diversities in multi-site brain MR images make it difficult to tune parameters specific to subjects or imaging protocols. Alternatively, using constant parameter settings often leads to inaccurate, inconsistent and even failed skull stripping results. One reason is that images scanned at different sites, under different scanners or protocols, and/or by different technicians often have very different fields of view (FOVs)...
January 20, 2018: Neuroinformatics
https://www.readbyqxmd.com/read/29332985/civility-cloud-based-interactive-visualization-of-tractography-brain-connectome
#2
Danaële Puechmaille, Martin Styner, Juan C Prieto
Cloud based Interactive Visualization of Tractography Brain Connectome (CIVILITY) is an interactive visualization tool of brain connectome in the cloud. This application submits tasks to remote computing grids were the CIVILITY-tractography pipeline is deployed. The application will list the running tasks for the user and once a task is completed the brain connectome is visualized using Hierarchical Edge Bundling. The analysis pipeline uses FSL tools (bedpostx and probtrackx2) to generate a triangular matrix indicating the connectivity strength between different regions in the brain...
March 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29261777/self-extracellular-rna-acts-in-synergy-with-exogenous-danger-signals-to-promote-inflammation
#3
Frederik Noll, Jonas Behnke, Silke Leiting, Kerstin Troidl, Gustavo Teixeira Alves, Holger Müller-Redetzky, Klaus T Preissner, Silvia Fischer
Self-extracellular RNA (eRNA), released from stressed or injured cells upon various pathological situations such as ischemia-reperfusion-injury, has been shown to act as an alarmin by inducing procoagulatory and proinflammatory responses. In particular, M1-polarization of macrophages by eRNA resulted in the expression and release of a variety of cytokines, including tumor necrosis factor (TNF)-α or interleukin-6 (IL-6). The present study now investigates in which way self-eRNA may influence the response of macrophages towards various Toll-like receptor (TLR)-agonists...
2017: PloS One
https://www.readbyqxmd.com/read/29242104/structural-network-differences-in-chronic-muskuloskeletal-pain-beyond-fractional-anisotropy
#4
James H Bishop, Marina Shpaner, Antoni Kubicki, Sarah Clements, Richard Watts, Magdalena R Naylor
Chronic musculoskeletal pain is a condition that influences central nervous system structure. In this study, we combined novel structural neuroimaging techniques, using well-validated software packages including FSL, Mrtrix3, and DSI Studio, to characterize brain grey (GM) and white matter (WM) differences in chronic musculoskeletal pain participants (n = 74), compared to age-matched pain-free controls (n = 31). In participants with chronic pain, we identified significantly higher volume in subcortical GM structures using voxel-based morphometry (FSLVBM)...
December 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/29235898/flash-glucose-measurements-in-children-with-type-1-diabetes-in-real-life-settings-to-trust-or-not-to-trust
#5
Agnieszka Szadkowska, Andrzej Gawrecki, Arkadiusz Michalak, Dorota Zozulińska-Ziółkiewicz, Wojciech Fendler, Wojciech Młynarski
BACKGROUND AND AIMS: To evaluate the clinical accuracy of a flash glucose monitoring device FreeStyle Libre (FSL) among children with type 1 diabetes in real-world settings during a summer camp. MATERIALS AND METHODS: During a summer camp, children with type 1 diabetes (n = 79, aged 8-18 years) were provided with FSLs for 12 days. On days 3, 7, and 11 of the study, they underwent supervised glucose testing at 8 timepoints. Glycemia was estimated by using FSL and measured with a personal glucometer within a period of 2 min...
December 13, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29230065/the-toll-like-receptor-2-6-agonist-fsl-1-lipopeptide-therapeutically-mitigates-acute-radiation-syndrome
#6
Cathryn J Kurkjian, Hao Guo, Nathan D Montgomery, Ning Cheng, Hong Yuan, Joseph R Merrill, Gregory D Sempowski, W June Brickey, Jenny P-Y Ting
Risks of radiation exposure from nuclear incidents and cancer radiotherapy are undeniable realities. These dangers urgently compel the development of agents for ameliorating radiation-induced injuries. Biologic pathways mediated by myeloid differentiation primary response gene 88 (MyD88), the common adaptor for toll-like receptor (TLR) and Interleukin-1 receptor signaling, are critical for radioprotection. Treating with agonists prior to radiation enhances survival by activating TLR signaling, whereas radiomitigating TLR-activating therapeutics given after exposure are less defined...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229410/pre-weaning-maternal-separation-increases-eating-later-in-life-in-male-and-female-offspring-but-increases-brainstem-dopamine-receptor-1a-and-2a-only-in-males
#7
Julliet Araújo de Souza, Matilde Cesiana da Silva, Rhowena Jane Barbosa de Matos, Larissa Cavalcanti do Amaral Almeida, Luana Cruz Beltrão, Felipe Leitão de Souza, Raul Manhães de Castro, Sandra Lopes de Souza
Maternal separation stress (MS) is a model of early life stress performed by the separation between dam and pups in the first days of life. This model has been associated with eating behavior and dopaminergic system abnormal phenotypes. This study aims to investigate whether maternal separation in the light or dark phase of the circadian cycle promotes phenotypic adjustments in the eating behavior and the dopamine system in both males and females. Lactating Wistar rats were separated from their litters from postnatal day 1 (PND 1) to PND 14 for 6 h in the light or dark phase of the circadian cycle...
December 8, 2017: Appetite
https://www.readbyqxmd.com/read/29228215/mitochondria-are-critical-for-bdnf-mediated-synaptic-and-vascular-plasticity-of-hippocampus-following-repeated-electroconvulsive-seizures
#8
Fenghua Chen, Maryam Ardalan, Betina Elfving, Gregers Wegener, Torsten M Madsen, Jens R Nyengaard
Background: Electroconvulsive therapy (ECT) is a fast acting and efficient treatment of depression used in the clinic. The underlying mechanism of its therapeutic effect is still unclear. However, recovery of synaptic connections and synaptic remodeling is thought to play a critical role for the clinical efficacy obtained from a rapid antidepressant response. Here, we investigated the relationship between, synaptic changes and concomitant non-neuronal changes in microvasculature and mitochondria, and it relationship to Brain-derived neurotrophic factor (BDNF) level changes after repeated electroconvulsive seizures (ECS), an animal model of ECT...
December 8, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29220695/altered-resting-state-functional-connectivity-in-early-course-schizophrenia
#9
Aastha Sharma, Arvind Kumar, Sadhana Singh, Triptish Bhatia, R P Beniwal, Subash Khushu, Konasale M Prasad, Smita N Deshpande
Impaired connectivity is proposed to underlie pathophysiology of schizophrenia. Existing studies on functional connectivity show inconsistent results. We examined functional connectivity in a clinically homogenous sample of 34 early course schizophrenia patients compared with/to 19 healthy controls using resting state functional magnetic resonance imaging (rsfMRI). Mean duration of illness for schizophrenia patients was 4 ± 1.78 years. Following a comprehensive clinical assessment, rsfMRI data were acquired using a 3...
November 22, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29188095/comparison-of-four-methods-of-surface-roughness-assessment-of-corneal-stromal-bed-after-lamellar-cutting
#10
Clotilde Jumelle, Alina Hamri, Gregory Egaud, Cyril Mauclair, Stephanie Reynaud, Virginie Dumas, Sandrine Pereira, Thibaud Garcin, Philippe Gain, Gilles Thuret
Corneal lamellar cutting with a blade or femtosecond laser (FSL) is commonly used during refractive surgery and corneal grafts. Surface roughness of the cutting plane influences postoperative visual acuity but is difficult to assess reliably. For the first time, we compared chromatic confocal microscopy (CCM) with scanning electron microscopy, atomic force microscopy (AFM) and focus-variation microscopy (FVM) to characterize surfaces of variable roughness after FSL cutting. The small area allowed by AFM hinders conclusive roughness analysis, especially with irregular cuts...
November 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29184534/pronounced-structural-and-functional-damage-in-early-adult-pediatric-onset-multiple-sclerosis-with-no-or-minimal-clinical-disability
#11
Antonio Giorgio, Jian Zhang, Maria Laura Stromillo, Francesca Rossi, Marco Battaglini, Lucia Nichelli, Marzia Mortilla, Emilio Portaccio, Bahia Hakiki, Maria Pia Amato, Nicola De Stefano
Pediatric-onset multiple sclerosis (POMS) may represent a model of vulnerability to damage occurring during a period of active maturation of the human brain. Whereas adaptive mechanisms seem to take place in the POMS brain in the short-medium term, natural history studies have shown that these patients reach irreversible disability, despite slower progression, at a significantly younger age than adult-onset MS (AOMS) patients. We tested for the first time whether significant brain alterations already occurred in POMS patients in their early adulthood and with no or minimal disability (n = 15) in comparison with age- and disability-matched AOMS patients (n = 14) and to normal controls (NC, n = 20)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29174479/practical-implementation-education-and-interpretation-guidelines-for-continuous-glucose-monitoring-a-french-position-statement
#12
S Borot, P Y Benhamou, C Atlan, E Bismuth, E Bonnemaison, B Catargi, G Charpentier, A Farret, N Filhol, S Franc, D Gouet, B Guerci, I Guilhem, C Guillot, N Jeandidier, M Joubert, V Melki, E Merlen, A Penfornis, S Picard, E Renard, Y Reznik, J P Riveline, S Rudoni, P Schaepelynck, A Sola-Gazagnes, N Tubiana-Rufi, O Verier-Mine, H Hanaire
The use by diabetes patients of real-time continuous interstitial glucose monitoring (CGM) or the FreeStyle Libre® (FSL) flash glucose monitoring (FGM) system is becoming widespread and has changed diabetic practice. The working group bringing together a number of French experts has proposed the present practical consensus. Training of professionals and patient education are crucial for the success of CGM. Also, institutional recommendations must pay particular attention to the indications for and reimbursement of CGM devices in populations at risk of hypoglycaemia...
November 11, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29164280/functional-brain-networks-involved-in-decision-making-under-certain-and-uncertain-conditions
#13
Danielle C Farrar, Asim Z Mian, Andrew E Budson, Mark B Moss, Ronald J Killiany
PURPOSE: The aim of this study was to describe imaging markers of decision-making under uncertain conditions in normal individuals, in order to provide baseline activity to compare to impaired decision-making in pathological states. METHODS: In this cross-sectional study, 19 healthy subjects ages 18-35 completed a novel decision-making card-matching task using a Phillips T3 Scanner and a 32-channel head coil. Functional data were collected in six functional runs...
November 21, 2017: Neuroradiology
https://www.readbyqxmd.com/read/29134725/reproducibility-of-brain-mri-segmentation-algorithms-empirical-comparison-of-local-map-pstaple-freesurfer-and-fsl-first
#14
Clemente Velasco-Annis, Alireza Akhondi-Asl, Aymeric Stamm, Simon K Warfield
BACKGROUND AND PURPOSE: Segmentation of human brain structures is crucial for the volumetric quantification of brain disease. Advances in algorithmic approaches have led to automated techniques that save time compared to interactive methods. Recently, the utility and accuracy of template library fusion algorithms, such as Local MAP PSTAPLE (PSTAPLE), have been demonstrated but there is little guidance regarding its reproducibility compared to single template-based algorithms such as FreeSurfer and FSL-FIRST...
November 14, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29128119/sensitivity-of-water-energy-nexus-to-dam-operation-a-water-energy-productivity-concept
#15
Mohammed Basheer, Nadir Ahmed Elagib
Understanding and modelling the complex nature of interlinkages between water and energy are essential for efficient use of the two resources. Hydropower storage dams represent an interesting example of the water-energy interdependencies since they are often multipurpose. The concept of Water-Energy Productivity (WEP), defined as the amount of energy produced per unit of water lost in the process, is introduced in this study to illustrate the relationship between energy generation and water losses by examining the sensitivity of the Water-Energy Nexus (WEN) to changing dam operation policy...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29124708/phototherapy-in-atopic-dermatitis
#16
José María Ortiz-Salvador, Amparo Pérez-Ferriols
Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases. Currently management of AD includes avoidance of triggering factors, skin care aiming to compensate the skin barrier defects, anti-inflammatory therapy (mostly topical corticosteroids and topical calcineurin inhibitors). When these first-line approaches are unsuccessful, systemic treatment or phototherapy ought to be carried out as next line of defence. Current phototherapy modalities for AD include broadband UVB (290-320 nm), narrowband UVB (311-313 nm), UVA-1 therapy (340-400 nm), UVA therapy plus 8-methoxypsoralens (PUVA), 308 nm excimer laser (EL) and Full spectrum light (FSL)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29113572/effects-of-an-individual-12-week-community-located-start-to-run-program-on-physical-capacity-walking-fatigue-cognitive-function-brain-volumes-and-structures-in-persons-with-multiple-sclerosis
#17
Peter Feys, Lousin Moumdjian, Florian Van Halewyck, Inez Wens, Bert O Eijnde, Bart Van Wijmeersch, Veronica Popescu, Paul Van Asch
BACKGROUND: Exercise therapy studies in persons with multiple sclerosis (pwMS) primarily focused on motor outcomes in mid disease stage, while cognitive function and neural correlates were only limitedly addressed. OBJECTIVES: This pragmatic randomized controlled study investigated the effects of a remotely supervised community-located "start-to-run" program on physical and cognitive function, fatigue, quality of life, brain volume, and connectivity. METHOD: In all, 42 pwMS were randomized to either experimental (EXP) or waiting list control (WLC) group...
November 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29101602/garcinia-mangostana-linn-displays-antidepressant-like-and-pro-cognitive-effects-in-a-genetic-animal-model-of-depression-a-bio-behavioral-study-in-the-flinders-sensitive-line-rat
#18
Inge Oberholzer, Marisa Möller, Brendan Holland, Olivia M Dean, Michael Berk, Brian H Harvey
There is abundant evidence for both disorganized redox balance and cognitive deficits in major depressive disorder (MDD). Garcinia mangostana Linn (GM) has anti-oxidant activity. We studied the antidepressant-like and pro-cognitive effects of raw GM rind in Flinders Sensitive Line (FSL) rats, a genetic model of depression, following acute and chronic treatment compared to a reference antidepressant, imipramine (IMI). The chemical composition of the GM extract was analysed for levels of α- and γ-mangostin...
November 3, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29095752/double-docking-technique-for-femtosecond-laser-assisted-deep-anterior-lamellar-keratoplasty
#19
Damien Guindolet, Diem T Nguyen, Ciara Bergin, Serge Doan, Isabelle Cochereau, Eric E Gabison
PURPOSE: To describe a new and safe surgical technique of deep anterior lamellar keratoplasty (DALK) using the femtosecond laser (FSL) and intraoperative optical coherence tomography (iOCT) for surgical management of corneal thinning and/or opacities. The technique was coined the double-docking procedure for DALK (DD-DALK). METHODS: FSL-integrated iOCT was used for direct visualization and calibration to perform precise anterior lamellar and side cuts for the removal of the anterior stroma...
October 31, 2017: Cornea
https://www.readbyqxmd.com/read/29092081/novel-findings-in-obstetric-brachial-plexus-palsy-a-study-of-corpus-callosum-volumetry-and-resting-state-functional-magnetic-resonance-imaging-of-sensorimotor-network
#20
Kishore Kislay, Bhagavatula Indira Devi, Dhananjaya Ishwar Bhat, Dhaval Prem Shukla, Arun Kumar Gupta, Rajanikant Panda
BACKGROUND: The response of the brain to obstetric brachial plexus palsy (OBPP) is not clearly understood. We propose that even a peripheral insult at the developmental stage may result in changes in the volume of white matter of the brain, which we studied using corpus callosum volumetry and resting-state functional magnetic resonance imaging (rsfMRI) of sensorimotor network. OBJECTIVE: To study the central neural effects in OBPP. METHODS: We performed an MRI study on a cohort of 14 children who had OBPP and 14 healthy controls...
October 28, 2017: Neurosurgery
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