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https://www.readbyqxmd.com/read/28794970/agreement-of-msmetrix-with-established-methods-for-measuring-cross-sectional-and-longitudinal-brain-atrophy
#1
Martijn D Steenwijk, Houshang Amiri, Menno M Schoonheim, Alexandra de Sitter, Frederik Barkhof, Petra J W Pouwels, Hugo Vrenken
INTRODUCTION: Despite the recognized importance of atrophy in multiple sclerosis (MS), methods for its quantification have been mostly restricted to the research domain. Recently, a CE labelled and FDA approved MS-specific atrophy quantification method, MSmetrix, has become commercially available. Here we perform a validation of MSmetrix against established methods in simulated and in vivo MRI data. METHODS: Whole-brain and gray matter (GM) volume were measured with the cross-sectional pipeline of MSmetrix and compared to the outcomes of FreeSurfer (cross-sectional pipeline), SIENAX and SPM...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28783513/platelet-toll-like-receptor-tlr-expression-and-tlr-mediated-platelet-activation-in-acute-myocardial-infarction
#2
Kathryn E Hally, Anne C La Flamme, Peter D Larsen, Scott A Harding
Both platelets and Toll-like receptors (TLRs) contribute to acute myocardial infarction (AMI). Platelet activation can occur post-AMI and despite treatment with anti-platelet therapy. TLRs may represent an alternative platelet activation pathway, although the role of platelet-TLRs in AMI is poorly characterized. The aim of this study was to examine platelet-TLR expression and TLR-mediated platelet activation in healthy and AMI subjects. Here, we report that platelets from AMI patients exhibit upregulation of some, but not other, TLRs...
August 1, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28777748/fully-automatic-mri-based-hippocampus-volumetry-using-fsl-first-intra-scanner-test-retest-stability-inter-field-strength-variability-and-performance-as-enrichment-biomarker-for-clinical-trials-using-prodromal-target-populations-at-risk-for-alzheimer-s-disease
#3
Enrica Cavedo, Per Suppa, Catharina Lange, Roland Opfer, Simone Lista, Samantha Galluzzi, Adam J Schwarz, Lothar Spies, Ralph Buchert, Harald Hampel
BACKGROUND: MRI-based hippocampus volume is a core clinical biomarker for identification of Alzheimer's disease (AD). OBJECTIVE: To assess robustness of automatic hippocampus volumetry with the freely available FSL-FIRST software with respect to short-term repeat and across field strength imaging. FSL-FIRST hippocampus volume (FIRST-HV) was also evaluated as enrichment biomarker for mild cognitive impairment (MCI) trials. METHODS: Robustness of FIRST-HV was assessed in 51 healthy controls (HC), 74 MCI subjects, and 28 patients with AD dementia from ADNI1, each with two pairs of back-to-back scans, one at 1...
July 29, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28734178/subcortical-surface-shape-in-youth-at-familial-high-risk-for-schizophrenia
#4
Kathryn Hill, Nicolas Bolo, Suraj Sarvode Mothi, Paulo Lizano, Synthia Guimond, Neeraj Tandon, Elena Molokotos, Matcheri Keshavan
Abnormalities in the subcortical brain regions that support cognitive functions have been reported in schizophrenia. Relatives of those with schizophrenia often present with psychosis-like traits (schizotypy) and similar cognition as those with schizophrenia. To evaluate the relationships between subcortical structure, schizotypy, and cognitive function, we assessed shape and volume of the hippocampus, amygdala and thalamus in untreated youth at familial high risk for schizophrenia (HRSZ). The sample consisted of 66 HRSZ and 69 age-matched healthy controls (HC)...
July 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28716114/visumax-femtolasik-versus-moria-m2-microkeratome-in-mild-to-moderate-myopia-efficacy-safety-predictability-aberrometric-changes-and-flap-thickness-predictability
#5
Magda A Torky, Yousif A Al Zafiri, Abeer M Khattab, Rania K Farag, Eman A Awad
INTRODUCTION: This is an interventional prospective clinical study which was conducted to evaluate the efficacy, safety, predictability, ocular aberrations, and flap thickness predictability of Visumax femtosecond laser (FSL) compared to Moria M2 microkeratome (MK) in mild to moderate myopia. METHODS: This study included 60 eyes who were divided into two groups. Thirty eyes in group (I) in which the flap was created with Visumax FSL, while in group II (30 eyes) the Moria M2 MK was used...
July 17, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28701991/an-arterial-spin-labeling-mri-perfusion-study-of-migraine-without-aura-attacks
#6
Raquel Gil-Gouveia, Joana Pinto, Patricia Figueiredo, Pedro Ferro Vilela, Isabel Pavão Martins
BACKGROUND: Studies of brain perfusion during migraine without aura attacks have inconsistent results. METHODS: Arterial spin labeling MRI, a non-invasive quantitative perfusion technique, was used to prospectively study a spontaneous untreated migraine without aura attack and a headache-free period. Image analysis used FSL and MATLAB software; Group analysis used permutation methods for perfusion differences between sessions. RESULTS: Thirteen women (age 35...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28667248/suppression-of-%C3%AE-v%C3%AE-6-integrin-expression-by-polymicrobial-oral-biofilms-in-gingival-epithelial-cells
#7
Jiarui Bi, Leeni Koivisto, Aihui Pang, Ming Li, Guoqiao Jiang, Saljae Aurora, Zhejun Wang, Gethin R Owen, Jiayin Dai, Ya Shen, Daniel Grenier, Markus Haapasalo, Lari Häkkinen, Hannu Larjava
Periodontal diseases manifest by the formation of deep pockets between the gingiva and teeth where multispecies bacterial biofilms flourish, causing inflammation and bone loss. Epithelial cell receptor αvβ6 integrin that regulates inflammation by activating the anti-inflammatory cytokine transforming growth factor-β1, is highly expressed in healthy junctional epithelium that connects the gingiva to the tooth enamel. However, its expression is attenuated in human periodontal disease. Moreover, Itgb6 (-/-) mice display increased periodontal inflammation compared to wild-type mice...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28649200/cognitive-variability-during-middle-age-possible-association-with-neurodegeneration-and-cognitive-reserve
#8
Daniel Ferreira, Alejandra Machado, Yaiza Molina, Antonieta Nieto, Rut Correia, Eric Westman, José Barroso
Objective: Increased variability in cognition with age has been argued as an indication of pathological processes. Focusing on early detection of neurodegenerative disorders, we investigated variability in cognition in healthy middle-aged adults. In order to understand possible determinants of this variability, we also investigated associations with cognitive reserve, neuroimaging markers, subjective memory complaints, depressive symptomatology, and gender. Method: Thirty-one 50 ± 2 years old individuals were investigated as target group and deviation was studied in comparison to a reference younger group of 30 individuals 40 ± 2 years old...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28648655/outcomes-of-foam-sclerotherapy-plus-ligation-versus-foam-sclerotherapy-alone-for-venous-ulcers-in-lower-extremities
#9
Xin Li, Lin Fan, Shiyan Ren, Xianlun Li
BACKGROUND: Foam sclerotherapy (FS) is a safe and effective approach for managing patients with varicose veins and venous ulcers in lower extremities. But, recanalization of the ablated varicose veins and phlebitis are common postoperative complications that jeopardize its clinical effects. We hypothesize that ligation of the ablated varicose veins after FS will improve the outcomes of patients with varicose veins and venous ulcer. This study was aimed to evaluate the clinical efficacy of ligation after FS in comparison with FS alone for the management of patients with varicose veins and venous ulcers in lower extremities...
June 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28647020/reprint-of-a-comprehensive-review-of-group-level-model-performance-in-the-presence-of-heteroscedasticity-can-a-single-model-control-type-i-errors-in-the-presence-of-outliers
#10
Jeanette A Mumford
Even after thorough preprocessing and a careful time series analysis of functional magnetic resonance imaging (fMRI) data, artifact and other issues can lead to violations of the assumption that the variance is constant across subjects in the group level model. This is especially concerning when modeling a continuous covariate at the group level, as the slope is easily biased by outliers. Various models have been proposed to deal with outliers including models that use the first level variance or that use the group level residual magnitude to differentially weight subjects...
July 1, 2017: NeuroImage
https://www.readbyqxmd.com/read/28626291/machine-learning-in-a-graph-framework-for-subcortical-segmentation
#11
Zhihui Guo, Satyananda Kashyap, Milan Sonka, Ipek Oguz
Automated and reliable segmentation of subcortical structures from human brain magnetic resonance images is of great importance for volumetric and shape analyses in quantitative neuroimaging studies. However, poor boundary contrast and variable shape of these structures make the automated segmentation a tough task. We propose a 3D graph-based machine learning method, called LOGISMOS-RF, to segment the caudate and the putamen from brain MRI scans in a robust and accurate way. An atlas-based tissue classification and bias-field correction method is applied to the images to generate an initial segmentation for each structure...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28604064/bolus-insulin-dose-error-distributions-based-on-results-from-two-clinical-trials-comparing-blood-glucose-monitoring-systems
#12
Scott Pardo, Nancy Dunne, David A Simmons
BACKGROUND: In 2 previous clinical trials, fingertip capillary blood samples were evaluated using prespecified blood glucose monitoring systems (BGMSs) and a reference YSI glucose analyzer. In post hoc analyses, hypothetical insulin doses were calculated using these blood glucose measurements; dosing errors were compared for each trial. METHOD: For each blood glucose measurement, premeal bolus insulin dosing was determined for a hypothetical person, assuming a 60-g carbohydrate meal and 100-mg/dL target blood glucose level (adjusting 1/25 insulin sensitivity and 1/15 insulin:carbohydrate ratio inputs to account for BGMS measurement error)...
June 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28583116/association-between-total-tau-and-brain-atrophy-one-year-after-first-ever-stroke
#13
Hege Ihle-Hansen, Guri Hagberg, Brynjar Fure, Bente Thommessen, Morten W Fagerland, Anne R Øksengård, Knut Engedal, Per Selnes
BACKGROUND: Although the most serious consequence of neuronal ischemia is acute neuronal death, mounting evidence suggests similarities between stroke and neurodegenerative disease. Brain atrophy visualized on structural MRI and pathological cerebrospinal fluid (CSF) concentrations of microtubule-associated protein tau (T-tau) and phosphorylated microtubule-associated protein tau indicate neurofibrillary degeneration. We aimed to explore the association between CSF T-tau and brain atrophy 1 year post-stroke...
June 5, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28580597/false-fmri-activation-after-motion-correction
#14
Renat Yakupov, Juan Lei, Michael B Hoffmann, Oliver Speck
Motion correction of echo-planar imaging (EPI) data used in functional MRI (fMRI) is an essential preprocessing step performed prior to statistical analysis. At ultra-high resolution fMRI, current requirements regarding translational and rotational motion may no longer be acceptable. This prompts the need for a systematic investigation of the effects of motion correction procedures with in vivo fMRI data. Here we systematically evaluated the effect of retrospective motion correction with freely available fMRI analysis software packages (FSL, AFNI, and SPM) on activation maps using fMRI data acquired with prospective motion detection, to identify and quantify confounding effects of retrospective motion correction, and to evaluate its dependence on spatial resolution and motion correction algorithms...
September 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28578128/an-ontologically-consistent-mri-based-atlas-of-the-mouse-diencephalon
#15
Charles Watson, Andrew L Janke, Carlo Hamalainen, Shahrzad M Bagheri, George Paxinos, David C Reutens, Jeremy F P Ullmann
In topological terms, the diencephalon lies between the hypothalamus and the midbrain. It is made up of three segments, prosomere 1 (pretectum), prosomere 2 (thalamus), and prosomere 3 (the prethalamus). A number of MRI-based atlases of different parts of the mouse brain have already been published, but none of them displays the segments the diencephalon and their component nuclei. In this study we present a new volumetric atlas identifying 89 structures in the diencephalon of the male C57BL/6J 12 week mouse...
May 31, 2017: NeuroImage
https://www.readbyqxmd.com/read/28574133/technical-feasibility-of-isolated-bowman-layer-graft-preparation-by-femtosecond-laser-a-pilot-study
#16
Jack S Parker, Forest Huls, Elizabeth Cooper, Paul Graves, Esther A Groeneveld-van Beek, Jessica Lie, Gerrit R J Melles
PURPOSE: To evaluate the technical feasibility of isolated Bowman layer (BL) graft preparation by femtosecond laser (FSL) and to compare the ultrastructural morphology to manually dissected grafts. METHODS: Five whole globes were placed in custom-made eye holders and debrided of epithelium. After programming a dissection depth of 20 μm, the FSL was docked into position and 5 isolated BL grafts were created. From 5 additional globes, corneoscleral buttons were procured, mounted in artificial anterior chambers, and stripped of BL via the previously described manual technique...
May 26, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28566144/the-anteroposterior-and-primary-to-posterior-limbic-ratios-as-mri-derived-volumetric-markers-of-alzheimer-s-disease
#17
Adolfo Jiménez-Huete, Susana Estévez-Santé
BACKGROUND/AIMS: Alzheimer's disease (AD) shows a characteristic pattern of brain atrophy, with predominant involvement of posterior limbic structures, and relative preservation of rostral limbic and primary cortical regions. We aimed to investigate the diagnostic utility of two gray matter volume ratios based on this pattern, and to develop a fully automated method to calculate them from unprocessed MRI files. PATIENTS AND METHODS: Cross-sectional study of 118 subjects from the ADNI database, including normal controls and patients with mild cognitive impairment (MCI) and AD...
July 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28546533/comparison-of-accuracy-between-fsl-s-first-and-freesurfer-for-caudate-nucleus-and-putamen-segmentation
#18
Gabor Perlaki, Reka Horvath, Szilvia Anett Nagy, Peter Bogner, Tamas Doczi, Jozsef Janszky, Gergely Orsi
Although several methods have been developed to automatically delineate subcortical gray matter structures from MR images, the accuracy of these algorithms has not been comprehensively examined. Most of earlier studies focused primarily on the hippocampus. Here, we assessed the accuracy of two widely used non-commercial programs (FSL-FIRST and Freesurfer) for segmenting the caudate and putamen. T1-weighted 1 mm(3) isotropic resolution MR images were acquired for thirty healthy subjects (15 females). Caudate nucleus and putamen were segmented manually by two independent observers and automatically by FIRST and Freesurfer (v4...
May 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28514787/delayed-effect-of-active-pressure-treatment-on-endolymphatic-hydrops
#19
Edoardo Covelli, Luigi Volpini, Francesca Atturo, Anna Teresa Benincasa, Chiara Filippi, Silvia Tarentini, Vania Marrone, Simonetta Monini, Annarita Vestri, Maurizio Barbara
OBJECTIVE: To identify eventual correlations between the effect of low-pressure treatment and endolymphatic hydrops in Ménière patients. MATERIAL AND METHODS: The study group consisted of subjects affected by definite Ménière disease (2015) and a severe degree of disability, who received a ventilation tube with or without a low-pressure treatment before undergoing a surgical procedure (vestibular neurectomy). After the placement of the ventilation tube, the subjects were either left alone with the tube or received 1 month of self-administered low-pressure therapy with a portable device...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28489723/femtosecond-laser-assisted-pterygium-surgery
#20
Matthias Fuest, Yu-Chi Liu, Minas T Coroneo, Jodhbir S Mehta
PURPOSE: Pterygium is a prevalent ocular surface disorder. Conjunctival autografting (CAG) after pterygium resection is the gold standard treatment. Thinner CAGs without Tenon tissue provide better results but are technically difficult to achieve. We report on the first femtosecond laser (FSL)-assisted pterygium surgery (FLAPS) in humans. METHODS: In a clinical trial, we treated 6 eyes of 5 patients with FLAPS. After manual removal of the pterygium, CAGs were dissected with the Ziemer Z8 at 60-μm depth and glued into the resection defect...
July 2017: Cornea
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