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Mauricio Gomez

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https://www.readbyqxmd.com/read/29930344/kr%C3%A3-ppel-like-factor-10-participates-in-cervical-cancer-immunoediting-through-transcriptional-regulation-of-pregnancy-specific-beta-1-glycoproteins
#1
Daniel Marrero-Rodríguez, Keiko Taniguchi-Ponciano, Malayannan Subramaniam, John R Hawse, Kevin S Pitel, Hugo Arreola-De la Cruz, Victor Huerta-Padilla, Gustavo Ponce-Navarrete, Ma Del Pilar Figueroa-Corona, Laura Gomez-Virgilio, Teresa I Martinez-Cuevas, Monica Mendoza-Rodriguez, Miriam Rodriguez-Esquivel, Pablo Romero-Morelos, Jorge Ramirez-Salcedo, Michael Baudis, Marco Meraz-Rios, Florinda Jimenez-Vega, Mauricio Salcedo
Cervical cancer (CC) is associated with alterations in immune system balance, which is primarily due to a shift from Th1 to Th2 and the unbalance of Th17/Treg cells. Using in silico DNA copy number analysis, we have demonstrated that ~20% of CC samples exhibit gain of 8q22.3 and 19q13.31; the regions of the genome that encodes the KLF10 and PSG genes, respectively. Gene expression studies demonstrated that there were no alterations in KLF10 mRNA expression, whilst the PSG2 and -5 genes were up-regulated by 1...
June 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29914817/efficacy-and-safety-of-sensor-augmented-pump-therapy-sapt-with-predictive-low-glucose-management-in-patients-diagnosed-with-type-1-diabetes-mellitus-previously-treated-with-sapt-and-low-glucose-suspend
#2
Ana María Gómez, Diana Cristina Henao, Angelica Imitola, Oscar Mauricio Muñoz, Martín Alonso Rondón Sepúlveda, Laura Kattah, Juan Sebastian Guerrero, Elly Morros, Juan Pablo Llano, Maira García Jaramillo, Fabián León-Vargas
BACKGROUND: Sensor-augmented insulin pump therapy (SAPT) with low-glucose suspend (LGS) is an effective and safe alternative for treating patients with type 1 diabetes mellitus (T1DM). New predictive low-glucose management (PLGM) systems decrease the severity and duration of hypoglycemic events. However, evidence of benefits in patients previously treated with SAPT-LGS is limited. METHODS: A prospective before-after study was conducted in patients with T1DM treated with SAPT-LGS, who were switched to the Minimed® 640G system with SmartGuard® to assess the impact on A1c levels, severe hypoglycemia (SH), hypoglycemia unawareness (HU), and area under the curve (AUC) <70mg/dL after three months of follow-up...
June 15, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29914007/the-kiss1-gene-overexpression-as-a-potential-molecular-marker-for-cervical-cancer-cells
#3
Keiko Taniguchi-Ponciano, Daniel Marrero-Rodríguez, Hugo Arreola-De la Cruz, Víctor Huerta-Padilla, Nancy Muñoz, Laura Gómez-Ortiz, Gustavo Ponce-Navarrete, Miriam Rodríguez-Esquivel, Mónica Mendoza-Rodríguez, Laura Gómez-Virgilio, Raúl Peralta, Luis Serna, Guillermo Gómez, Jorge Ortiz, Alejandra Mantilla, Daniel Hernández, Ángeles Hernández, Cindy Bandala, Rosa María Ribas-Aparicio, Mauricio Salcedo
BACKGROUND: Similarities between the pathologic progression of cancer and the physiologic process of placentation have been recognized for many years proposing that both present similar mechanisms and processes. Cervical cancer (CC) is one of the most frequent neoplasia among Mexican women turning it into an important health problem. OBJECTIVE: The aim of this study was to determine the degree of the involvement of pregnancy related genes and in cancer progression by insilico analysis and validated in CC samples...
May 31, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29900191/data-on-the-role-of-iba57p-in-free-fe-2-release-and-o-2-%C3%A2-generation-in-saccharomyces-cerevisiae
#4
Mauricio Gomez-Gallardo, Luis A Sánchez, Alma L Díaz-Pérez, Christian Cortés-Rojo, Jesús Campos-García
The related study has confirmed that in Saccharomyces cerevisiae , iba57 protein participates in maturation of the [2Fe-2S] cluster into the Rieske protein, which plays important roles in the conformation and functionality of mitochondrial supercomplexes III/IV in the electron transport chain (Sánchez et al., 2018) [1]. We determined in S. cerevisiae the effects of mutation in the IBA57 gene on reactive oxygen species (ROS) and iron homeostasis. Flow cytometry and confocal microscopy analyses showed an increased generation of ROS, correlated with free Fe2+ release in the IBA57 mutant yeast...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29867666/manipulating-the-alpha-level-cannot-cure-significance-testing
#5
REVIEW
David Trafimow, Valentin Amrhein, Corson N Areshenkoff, Carlos J Barrera-Causil, Eric J Beh, Yusuf K Bilgiç, Roser Bono, Michael T Bradley, William M Briggs, Héctor A Cepeda-Freyre, Sergio E Chaigneau, Daniel R Ciocca, Juan C Correa, Denis Cousineau, Michiel R de Boer, Subhra S Dhar, Igor Dolgov, Juana Gómez-Benito, Marian Grendar, James W Grice, Martin E Guerrero-Gimenez, Andrés Gutiérrez, Tania B Huedo-Medina, Klaus Jaffe, Armina Janyan, Ali Karimnezhad, Fränzi Korner-Nievergelt, Koji Kosugi, Martin Lachmair, Rubén D Ledesma, Roberto Limongi, Marco T Liuzza, Rosaria Lombardo, Michael J Marks, Gunther Meinlschmidt, Ladislas Nalborczyk, Hung T Nguyen, Raydonal Ospina, Jose D Perezgonzalez, Roland Pfister, Juan J Rahona, David A Rodríguez-Medina, Xavier Romão, Susana Ruiz-Fernández, Isabel Suarez, Marion Tegethoff, Mauricio Tejo, Rens van de Schoot, Ivan I Vankov, Santiago Velasco-Forero, Tonghui Wang, Yuki Yamada, Felipe C M Zoppino, Fernando Marmolejo-Ramos
We argue that making accept/reject decisions on scientific hypotheses, including a recent call for changing the canonical alpha level from p = 0.05 to p = 0.005, is deleterious for the finding of new discoveries and the progress of science. Given that blanket and variable alpha levels both are problematic, it is sensible to dispense with significance testing altogether. There are alternatives that address study design and sample size much more directly than significance testing does; but none of the statistical tools should be taken as the new magic method giving clear-cut mechanical answers...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29844066/differential-role-of-the-rasgefs-sos1-and-sos2-in-mouse-skin-homeostasis-and-carcinogenesis
#6
Pilar Liceras-Boillos, David Jimeno, Rósula García-Navas, L Francisco Lorenzo-Martín, Mauricio Menacho-Marquez, Carmen Segrelles, Carmela Gómez, Nuria Calzada, Rocío Fuentes-Mateos, Jesús M Paramio, Xosé R Bustelo, Fernando C Baltanás, Eugenio Santos
Using Sos1-KO, Sos2-KO and Sos1/2-DKO mice, we assessed the functional role of Sos1 and Sos2 in skin homeostasis under physiological and/or pathological conditions. Sos1 depletion resulted in significant alterations of skin homeostasis including reduced keratinocyte proliferation, altered hair follicle and blood vessel integrity in dermis, and reduced adipose tissue in hypodermis. These defects worsened significantly when both Sos1 and Sos2 were absent. Simultaneous Sos1/2 disruption led to severe impairment of the ability to repair skin wounds as well as to almost complete ablation of the neutrophil-mediated inflammatory response in the injury site...
May 29, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29789229/cryoglobulinemic-vasculitis-and-psoriatic-arthritis-case-report-of-an-unusual-association
#7
Lizeth Yamile Urrea-Pineda, Sebastián Gómez-Jiménez, Daniel Jaramillo-Arroyave, Carlos Horacio Muñoz-Vahos, Adriana Lucía Vanegas-García, Gloria Vasquéz, Mauricio Restrepo-Escobar, Luis Alonso González-Naranjo
We report the case of a 47-year-old man with a 9-year history of psoriatic arthritis (PsA) in whom we detected renal involvement, hypocomplementemia, peripheral neuropathy, acral necrotic lesions and positive cryoglobulins. The results of the diagnosis led us to conclude that the clinical picture corresponded to cryoglobulinemic vasculitis concomitant with PsA. In addition, we present a review of the literature on the presence of these two diseases in a single patient.
May 19, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29784675/radiation-followed-by-ox40-stimulation-drives-local-and-abscopal-antitumor-effects-in-an-anti-pd1-resistant-lung-tumor-model
#8
Sharareh Niknam, Hampartsoum B Barsoumian, Jonathan E Schoenhals, Heather Jackson, Niranjan Yanamandra, Mauricio S Caetano, Ailin Li, Ahmed I Younes, Alexandra P Cadena, Taylor R Cushman, Joe Y Chang, Quynh Nguyen, Daniel R Gomez, Adi Diab, John V Heymach, Patrick Hwu, Maria Angelica Cortez, James W Welsh
PURPOSE: Radiation is used extensively to treat localized cancer, but improved understanding of its effects on the immune system have increased interest in its potential systemic (abscopal) effects, particularly in combination with checkpoint inhibitors such as anti-PD1. The majority of patients either do not respond or develop resistance to monotherapy over time. Here, we investigated the efficacy of OX40 (CD134) stimulation as an alternative immunotherapeutic approach in combination with radiotherapy (XRT) in a murine model of anti-PD1-resistant lung tumors...
May 21, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29763346/mandibular-condylar-aplasia-treated-with-a-functional-appliance-a-five-years-follow-up
#9
Mejia-Gomez Carlos Mauricio, Ramirez-Yanez German Omar
This report presents a follow up of a clinical case published five years ago by the same authors. In the previous report, the authors showed a young girl treated with a myofunctional appliance due to a mandibular condylar agenesia. After a traditional graft had failed, the patient successfully responded to the functional treatment by forming a mandibular condyle. In this new report, the authors are showing how the mandibular condyle has continued developing within normal limits and, the mandibular ramus has continued positively remodeling...
May 15, 2018: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29746741/-overweight-and-obesity-in-children-and-adolescents-2016-halfway-national-health-and-nutrition-survey-update
#10
Teresa Shamah-Levy, Lucía Cuevas-Nasu, Elsa Berenice Gaona-Pineda, Luz María Gómez-Acosta, María Del Carmen Morales-Rúan, Mauricio Hernández-Ávila, Juan Ángel Rivera-Dommarco
OBJECTIVE: To estimate recent overweight and obesity prevalences in Mexican population under 20 years from Halfway National Health and Nutrition Survey (Ensanut MC 2016). MATERIALS AND METHODS: Ensanut MC 2016 is a probabilistic national survey which gives representative information from national, regional and rural/urban levels. BMIz was estimated through weight and height, then it was classified into overweight risk or overweight or obesity ac¬cording to WHO growth reference standards...
May 2018: Salud Pública de México
https://www.readbyqxmd.com/read/29680185/a-dual-process-perspective-on-advances-in-cognitive-science-and-alcohol-use-disorder
#11
REVIEW
Kristen P Lindgren, Christian S Hendershot, Jason J Ramirez, Edward Bernat, Mauricio Rangel-Gomez, Kirsten P Peterson, James G Murphy
There is a tremendous global and national (US) burden associated with alcohol misuse and alcohol use disorder (AUD). Further, of the mental health disorders, AUD has the widest treatment gap. Thus, there is a critical need for improved understanding of the etiology, maintenance, and treatment of AUD. The application of cognitive science to the study of AUD has a longstanding history of attempting to meet this need. In this selective review, we identified and focused on four domains of recent (i.e., in the last decade) applications of cognitive science to the study of AUD: implicit cognitive biases, executive function, behavioral economic approaches to alcohol decision making, and functional connectivity neuroimaging...
April 11, 2018: Clinical Psychology Review
https://www.readbyqxmd.com/read/29651160/structure-and-co-occurrence-patterns-in-microbial-communities-under-acute-environmental-stress-reveal-ecological-factors-fostering-resilience
#12
Dinka Mandakovic, Claudia Rojas, Jonathan Maldonado, Mauricio Latorre, Dante Travisany, Erwan Delage, Audrey Bihouée, Géraldine Jean, Francisca P Díaz, Beatriz Fernández-Gómez, Pablo Cabrera, Alexis Gaete, Claudio Latorre, Rodrigo A Gutiérrez, Alejandro Maass, Verónica Cambiazo, Sergio A Navarrete, Damien Eveillard, Mauricio González
Understanding the factors that modulate bacterial community assembly in natural soils is a longstanding challenge in microbial community ecology. In this work, we compared two microbial co-occurrence networks representing bacterial soil communities from two different sections of a pH, temperature and humidity gradient occurring along a western slope of the Andes in the Atacama Desert. In doing so, a topological graph alignment of co-occurrence networks was used to determine the impact of a shift in environmental variables on OTUs taxonomic composition and their relationships...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29627640/genetic-variants-structural-and-functional-changes-of-myelin-protein-zero-and-mannose-binding-lectin-2-protein-involved-in-immune-response-and-its-allelic-transmission-in-families-of-patients-with-leprosy-in-colombia
#13
Viviana Cardona-Pemberthy, Michelle Rendón, Juan Camilo Beltrán, Alejandro Soto-Ospina, Amalia Muñoz-Gomez, Pedronel Araque-Marín, Mauricio Corredor, Gabriel Bedoya, Nora Cardona-Castro
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Genetic factors associated with immune response contribute to infection development and disease. M. leprae has the capacity to invade Schwann cells in the peripheral nervous system and cause neuropathy. However, while the responsible molecular mechanisms remain to be fully unveiled, they have begun being elucidated. We studied genetic variants Myelin Protein Zero (MPZ), a major structural component of the myelin sheath, and Mannose Binding Lectin 2 (MBL2), a protein involved in immune response, in 112 family groups of 114 leprosy patients using PCR-RFLP, aiming to calculate the association and allelic transmission of variants associated in first, second and third-degree relatives...
July 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29624493/efficacy-and-safety-of-0-6-pazufloxacin-ophthalmic-solution-versus-moxifloxacin-0-5-and-gatifloxacin-0-5-in-subjects-with-bacterial-conjunctivitis-a-randomized-clinical-trial
#14
Leopoldo Baiza-Durán, Oscar Olvera-Montaño, Arieh R Mercado-Sesma, Aldo A Oregon-Miranda, Alfredo Lizárraga-Corona, Juan C Ochoa-Tabares, Ana L Pérez-Balbuena, Irene M Montoya-Sánchez, Laura R Saucedo-Rodríguez, Alfredo Mora-González, Pedro A Gómez-Bastar, Miguel A Villanueva-Najera, Laura I Sandoval-Delgadillo, M González-Lomelí, Juan H Páez-Garza, Mónica Orozco-Carroll, Mauricio Casillas-Magallanes
PURPOSE: The purpose of this study was to evaluate the clinical efficacy and safety of a novel ophthalmic solution of pazufloxacin on the ocular surface of patients with bacterial conjunctivitis after 7 days of intervention. METHODS: This is a phase 2, double-blind, controlled, multicenter, clinical trial of 300 subjects, randomized to either a 3 dosing regimen of pazufloxacin 0.6% ophthalmic solution (twice a day [BID], n = 90; 3 times a day [TID], n = 76; 4 times a day [QID], n = 68), moxifloxacin 0...
April 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29616713/mental-health-in-displaced-children-by-armed-conflict-national-mental-health-survey-colombia-2015
#15
Carlos Gómez-Restrepo, Viviana Cruz-Ramírez, Mauricio Medina-Rico, Carlos J Rincón
INTRODUCTION: The armed conflict in Colombia is considered one of the most violent in Latin America. Children as a vulnerable population are most affected, increasing their risk of developing mental problems such as anxiety disorder and post-traumatic stress disorder. OBJECTIVES: To determine the prevalence of the most frequent mental problems in the Colombian children affected by armed conflict. METHODOLOGY: A cross-sectional study, using data from the National Mental Health Survey 2015...
March 2018: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/29570254/diagnostic-accuracy-of-multiparametric-magnetic-resonance-imaging-in-detecting-extracapsular-extension-in-intermediate-and-high-risk-prostate-cancer
#16
Cristina Dominguez, Mauricio Plata, Juan Guillermo Cataño, Mauricio Palau, Diego Aguirre, Jorge Narvaez, Stephanie Trujillo, Felipe Gómez, Carlos Gustavo Trujillo, Juan Ignacio Caicedo, Camilo Medina
OBJECTIVES: To evaluate the diagnostic performance of preoperative multiparametric magnetic resonance imaging (mp-MRI) as a predictor of extracapsular extension (ECE) and unfavorable Gleason score (GS) in patients with intermediate and high-risk prostate cancer (PCa). MATERIALS AND METHODS: Patients with clinically localized PCa who underwent radical prostatectomy (RP) and had preoperative mp-MRI between May-2011 and December-2013. Mp-MRI was evaluated according to the European Society of Urogenital Radiology MRI prostate guidelines by two different readers...
March 23, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29466525/-chronic-diseases-in-the-population-affected-by-the-armed-conflict-in-colombia-2015
#17
Carlos Gómez-Restrepo, Carlos Javier Rincón, Mauricio Medina-Rico
OBJECTIVE: The purpose of this study was to identify the most frequent non-mental chronic illnesses in the Colombian population affected by the armed conflict. METHODOLOGY: A cross-sectional study using data from the National Mental Health Survey 2015. The study population was stratified by sex and age and other general data were extracted, including education and poverty level, measured by the Multidimensional Poverty Index. Data analysis was based on information from people who reported having been victims of the Colombian armed conflict at some time in their lives; the frequency of presentation of non-mental chronic illnesses was reported as a measure of indirect relative risk...
February 19, 2018: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/29451631/-effects-of-saludarte-program-in-feeding-and-nutrition-components-in-school-children-in-mexico-city
#18
Teresa Shamah-Levy, Lucía Cuevas-Nasu, Luz María Gómez-Acosta, Ma Del Carmen Morales-Ruan, Ignacio Méndez-Gómez Humarán, Mara Nadiezhda Robles-Villaseñor, Mauricio Hernández-Ávila
OBJECTIVE: To assess the effect of Education in Nutrition and Food Assistance components of the SaludArte program in participant schools during 2013-2015. MATERIALS AND METHODS: A three cohort comparative study was used, with two type of follow-up panel structures: a complete panel and a continuous time, with a total of consisting on 1620 scholar children from 144 schools. Information on food intake, feeding behaviors, food preservation and hygiene, physical activity (PI) and anthropometry was registered...
November 2017: Salud Pública de México
https://www.readbyqxmd.com/read/29451006/different-indexes-of-glycemic-variability-as-identifiers-of-patients-with-risk-of-hypoglycemia-in-type-2-diabetes-mellitus
#19
Ana M Gómez, Oscar M Muñoz, Alejandro Marin, Maria Camila Fonseca, Martin Rondon, María Alejandra Robledo Gómez, Andrei Sanko, Dilcia Lujan, Maira García-Jaramillo, Fabian Mauricio León Vargas
INTRODUCTION: Recent publications frequently introduce new indexes to measure glycemic variability (GV), quality of glycemic control, or glycemic risk; however, there is a lack of evidence supporting the use of one particular parameter, especially in clinical practice. METHODS: A cohort of type 2 diabetes mellitus (T2DM) patients in ambulatory care were followed using continuous glucose monitoring sensors (CGM). Mean glucose (MG), standard deviation, coefficient of variation (CV), interquartile range, CONGA1, 2, and 4, MAGE, M value, J index, high blood glucose index, and low blood glucose index (LBGI) were estimated...
February 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29371371/genome-sequence-of-a-rabies-virus-isolated-from-a-dog-in-chiapas-mexico-2013
#20
Sandra Pérez-Agüeros, Joanna María Ortiz-Alcántara, Fabiola Garcés-Ayala, Edgar Mendieta-Condado, Elizabeth González-Durán, Nidia Aréchiga-Ceballos, Martin Melo-Munguía, Susana Chávez-López, Albert Sandoval-Borja, Mauricio Gómez-Sierra, Rita Terán-Toledo, David Martínez-Solís, Israel Animas-Vargas, Beatriz Escamilla-Ríos, Belem Torres-Longoria, Irma López-Martínez, Lucía Hernández-Rivas, José Alberto Díaz-Quiñonez, José Ernesto Ramírez-González
Rabies virus (RABV), a member of the genus Lyssavirus , causes encephalitis that is almost always fatal following the onset of clinical signs. Here, we report the complete codifying sequence of an RABV isolated from a dog in Mexico. Molecular data showed that this strain belongs to the Chiapas lineage.
January 25, 2018: Genome Announcements
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