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Juan Sebastián Peinado-Acevedo, Estephanía Chacón-Valenzuela, Laura Liliana Rodríguez-Moncada
The bronze baby syndrome is an infrequent dyschromia resulting from phototherapy in newborn babies with neonatal jaundice. Even though the common phenotype has been described in patients with direct neonatal hyperbilirubinemia secondary to cholestasis, several cases of patients with indirect neonatal hyperbilirubinemia who have managed to reverse it have been reported, as well as patients with isolated hyperbilirubinemia.Currently, the physiopathology of this condition is still a subject of controversy and, therefore, there is a lack of clear conducts for its correct diagnosis and treatment...
May 1, 2018: Biomédica: Revista del Instituto Nacional de Salud
Jesús A Bahena-Aponte, Guillermo Ramírez de Aguilar, Juan Carlos Torres Carrillo, Luis Espino Urbina, Jesús A Sánchez González
We present the case of a 34 years old female patient who presents with abdominal pain and elevated total and direct bilirrubins, so she underwent ERCP Reporting: a) successful sphincterotomy without complications, b) choledocholithias is endoscopically resolved, c) secondary cholangitis. She developed significant abdominal pain at 72 h, with hypovolemic shock and peritoneal irritation. She was taken to the surgery, finding a grade III liver laceration. This one was resolved with liver raffia and packing, during the same operative time cholecystectomy was performed...
July 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
Patricia Guzman Rojas, Roxana Gallegos Lopez, Alessandra Ciliotta Chehade, Yolanda Scavino, Alejandro Morales, Martín Tagle
We describe a case of a teenage patient with the diagnosis of drug induced autoimmune hepatitis. The patient is a 16 years old female, with the past medical history of Hashimoto’s hypothyroidism controlled with levothyroxine, who started treatment with Isotretionin (®Accutane) 20 mg q/12 hours for a total of 3 months for the treatment of severe acne. The physical examination was within normal limits and the results of the laboratory exams are: Baseline values of ALT 28 U/L, AST 28 U/L. Three months later: AST 756 U/L, ALT 1199U/L, alkaline phosphatase 114 U/L, with normal bilirrubin levels throughout the process...
January 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
Francislaine Veiga da Silva, Priscila Menezes Ferri, Thaís Costa Nascentes Queiroz, Pamela de Souza Haueisen Barbosa, Maria Cristina Cassiano de Oliveira, Laura Jácome de Melo Pereira, Ana Cristina Simões E Silva, Francisco José Penna, Eleonora Druve Tavares Fagundes, Alexandre Rodrigues Ferreira
OBJECTIVE: To evaluate the nutritional status of children with persistent cholestasis and to compare the anthropometric indices between children with and without liver cirrhosis and children with and without jaundice. METHODS: Children with persistent cholestasis, i.e. increased direct bilirrubin or changes in the canalicular enzyme gamma-glutamyl transferase (GGT), were included. The anthropometric measures were weight (W), height or length (H), arm circumference (AC), triceps skinfold thickness (TST), arm muscle circumference (AMC), and body mass index (BMI)...
March 2016: Jornal de Pediatria
Maria Teresa Arias-Loste, Maria Teresa García-Unzueta, Susana Llerena, Paula Iruzubieta, Angela Puente, Joaquín Cabezas, Carmen Alonso, Antonio Cuadrado, José Antonio Amado, Javier Crespo, Emilio Fábrega
AIM: To investigate the plasma levels of betatrophin in patients with cirrhosis. METHODS: Forty patients diagnosed at the clinic with liver cirrhosis according to biological, ultrasonographic, or histological criteria were included. The severity of cirrhosis was classified according to Pugh's modification of Child's classification and MELD score. Insulin resistance (IR) was assessed by the Homeostasis Model Assessment. A total of 20 patients showed a MELD score higher than 14...
October 7, 2015: World Journal of Gastroenterology: WJG
Gonzalo Barge-Caballero, Eduardo Barge-Caballero, Raquel Marzoa-Rivas, María J Paniagua-Martín, Alfredo Barrio-Rodríguez, Carmen Naya-Leira, Paula Blanco-Canosa, Zulaika Grille-Cancela, José Manuel Vázquez-Rodríguez, María G Crespo-Leiro
We conducted an observational study of 30 heart transplant recipients with serum low-density lipoprotein cholesterol (LDL-c) >100 mg/dl despite previous statin therapy, who were treated with rosuvastatin 10 mg daily (5 mg in case of renal dysfunction). Serum lipids, creatine phosphokinase (CPK), bilirubin, and hepatic enzymes were prospectively measured 2, 4, and 12 weeks after the initiation of the drug. Clinical outcomes of patients who continued on long-term rosuvastatin therapy beyond this 12-week period were reviewed in February 2015...
September 2015: Transplant International: Official Journal of the European Society for Organ Transplantation
Ileana Lorenzana-Bautista, Aníbal Flores-Plascencia, Francisco Javier Barrios-Pineda, Georgia Alderete-Vázquez, Enrique Alejandro Sánchez-Valdivieso
BACKGROUND: A significant number of people suffer iatrogenic bile duct injury during laparoscopic cholescystectomy. Biliary-digestive bypass may be complicated by stenosis and biliary sepsis, affecting both quality of life and life expectancy. To avoid bypass synthetic grafts have been used, which are expensive. OBJECTIVE: Evaluating autologous implantation of peritoneus as alternative of bile duct repair. METHODS: Under general anesthesia, ten New Zealand adult rabbits were operated, common bile duct approached and sectioned underneath the cystic duct followed by a liver biopsy...
September 2013: Cirugia y Cirujanos
Rafael Ramos da Silva, Michelly Cristiny Pereira, Moacyr Jesus Barreto Melo Rêgo, Betania Lucena Domingues Hatzlhofer, Aderson da Silva Araújo, Marcos André Cavalcanti Bezerra, Ivan da Rocha Pitta, Maira Galdino da Rocha Pitta
Leg ulcers (LUs) represent one of the main causes of morbidity in sickle cell anemia (SCA). This manifestation has been related to hemolysis, infections predisposition and inflammation that leads cytokines secretion. In this context, our study aimed to evaluate Th17 related cytokines (IL-6, IL-17A, IL-22 and IL-23) in serum and peripheral mononuclear cells culture supernatants with and without lymphoproliferative stimulation (anti-human CD3 and anti-human CD28). The cytokines levels were also correlated to clinical, hematological and biochemical parameters in SCA patients with and without LUs history (SCALU and SCAWH) as well as in healthy controls...
February 2014: Cytokine
Rogério Heggendorn Sayão Filho, Marcos Vinicius Perini, José Arnaldo Cruz, Juliana Requena, Hermes Vieira Barbeiro, Nilza Trindade Molan, Fabio Pinatel Lopasso, Luiz Augusto Carneiro D'Albuquerque, Ivan Cecconello
PURPOSE: To investigate superoxide dismutase (SOD) activity in the portal vein endothelium and malondialdehyde acid (MDA) production in liver tissue of rats submitted to 70% hepatectomy. METHODS: Twelve rats were distributed in two groups (hepatectomy and sham). Animals were sacrificed on post operative day 1 and portal vein, liver tissue and blood samples were collected. Portal vein SOD production was measured using lucigenin-amplified chemiluminescence assays...
September 2013: Acta Cirúrgica Brasileira
V M Santos, R B Villaça, C S Marinho, P R M Nogueira Junio, C O Maia
This challenging condition has scarcely been reported on. A 56-year-old woman was admitted with jaundice, and laboratory data were indicative of pancreatitis, which recurred in spite of adequate clinical and nutritional management. The patient was an overweight diabetic using metformin, who had antecedents of cholelithiasis and recent cholecystectomy. Clinical and laboratory features were not conclusive about the cause of this acute pancreatitis. However, imaging data contributed to diagnosis suspicion, and the histopathology study of the transpapillary biopsy confirmed the ampullary adenocarcinoma...
September 2012: Anales del Sistema Sanitario de Navarra
E Díaz de León González, H Gutiérrez Hermosillo, Y O Piquet Uscanga, C García Vallejo, C A Vázquez Martínez, G Alvarado Zaldivar, H E Tamez Pérez
INTRODUCTION: the abnormalities in liver function tests (LFTs) and liver complications (LC) from parenteral nutrition (PN) are common and usually multifactorial. These factors have not yet been assessed in the adult Mexican population. OBJECTIVE: To determine whether the dose prescribed > 1 g/kg is a risk factor for the abnormalities in liver function tests (LFTs) from PN. MATERIAL AND METHODS: Cohort study including patients older than 15 years and excluding those managed at the intensive car unit or with abnormalities in liver enzymes before the start of PN...
July 2011: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Jorge E Lopera
Transjugular intrahepatic portosystemic shunts (TIPS) is a highly effective treatment for bleeding esophageal varices, with control of the bleeding in over 90% of the patients. TIPS is recommended as "rescue" treatment if primary hemostasis cannot be obtained with endoscopic and pharmacological therapy, or if uncontrollable early rebleeding occurs within 48 hours. TIPS is also a very effective technique for patients presenting with severe refractory bleeding gastric and ectopic varices, cases where endoscopic techniques are less effective...
December 2005: Seminars in Interventional Radiology
J Campistol, H Galvez, A García Cazorla, I Málaga, M Iriondo, V Cusí
INTRODUCTION: "Kernicterus" is a term currently used to describe bilirrubin induced brain injury in the neuro-pathological studies. This is a confusing term and nowadays we prefer bilirrubin encephalopathy or bilirrubin induced neurological dysfunction. The clinical signs vary and it is clearly decreasing in prevalence in developed countries. MATERIAL AND METHODS: We review a series of 7 patients with bilirrubin encephalopathy and variable neurological manifestations, who were seen in the Neuropaediatric Department in the last 10 years...
May 2012: Neurología: Publicación Oficial de la Sociedad Española de Neurología
Lysandro Alsina Nader, Angelo Alves de Mattos, Pedro Dornelles Picon, Sérgio Luis Bassanesi, Angelo Zambam De Mattos, Margarita Pineiro Rodriguez
BACKGROUND AND RATIONALE: Among the adverse events related to tuberculosis treatment, hepatotoxicity is the most serious, and recognition of risk factors for it is essential to achieve successful therapy. The aim of the study is to evaluate the role of anti-HCV as a risk factor for hepatotoxicity in hospitalized patients under tuberculosis treatment with rifampicin, isoniazid and pyrazinamide (RHZ). METHODS: Historical cohort study carried out at Hospital Sanatório Partenon, from 1998 to 2006...
January 2010: Annals of Hepatology
Francisco Barrera, Arnoldo Riquelme, Alejandro Soza, Alvaro Contreras, Gerty Barrios, Oslando Padilla, Paola Viviani, Rosa María Pérez-Ayuso
BACKGROUND AND OBJECTIVE: Prophylaxis therapy is indicated in cirrhotic patients with large esophageal varices or small varices with red wale signs (high risk esophageal varices; HREV). Endoscopic surveillance to detect HREV is currently recommended. The objective of this study is to identify non-invasive predictors of HREV in cirrhotic patients. DESIGN AND METHODS: Adult cirrhotic patients without previous variceal bleeding were prospectively included. All patients underwent a complete biochemical workup, upper digestive endoscopy, and ultrasonographic measurement of spleen bipolar diameter...
October 2009: Annals of Hepatology
Isidro Martínez-Casas, Juan J Sancho, Esther Nve, Maria-José Pons, Estela Membrilla, Luis Grande
INTRODUCTION: The aim of this work was to analyze preoperative mortality risk factors after relaparotomy for abdominal surgery in a unit of General Surgery at a University Hospital. METHODS: A total of 314 relaparotomies in 254 patients were performed between February 2004 and February 2008. We analyzed data about past medical history, first operation, as well as clinical and biochemical parameters previous to reoperation. RESULTS: Indications for relaparotomy were peritonitis, bleeding, abscess, exploratory laparotomy, and evisceration...
June 2010: Langenbeck's Archives of Surgery
Juan C Montejo González, Mercedes Catalán González, Juan C Meneu Díaz, Almudena Moreno Elola-Olaso, Javier De la Cruz, Enrique Moreno González
BACKGROUND/AIMS: To assess the efficacy of the Molecular Adsorbent Recirculating System MARS (GAMBRO LUNDIA AB, Europe) in patients with acute liver failure waiting for liver transplantation. METHODOLOGY: Case-control study in a medical-surgical ICU of a referral hospital. Patients admitted to ICU with severe acute liver failure of any etiology were included. Conventional treatment was applied in all cases according to patient's clinical condition. Patients were treated with MARS after the implementation of this therapy in the ICU...
March 2009: Hepato-gastroenterology
Luis Servia, Joan Antonio Schoenenberger, Javier Trujillano, Mariona Badia, Angel Rodríguez-Pozo
BACKGROUND AND OBJECTIVE: The objective of this study is to describe the incidence of hepatic dysfunction (HD) in our hospital and evaluate the possible risk factors associated with HD development as an improvement of the caring process received by patients treated with parenteral nutrition (PN). PATIENTS AND METHOD: A prospective study of patients (n=994) who required PN during the period 2000-2004. HD is the identification of an increase above 1,5 of the top reference value of alkaline phosphatase (40-450U/l) and gamma glutamyl transpeptidase (11-49U/l) associated with an increase of transaminases (5-32U/l) and a total bilirrubin higher than 1,2mg/dl...
February 7, 2009: Medicina Clínica
Cristina W Nogueira, Lysandro Pinto Borges, Ana Cristina Guerra Souza
Carbon tetrachloride (CCl4) is a model for studying free radical-induced liver injury and screening hepato-protective drugs. Numerous studies have reported the involvement of oxidative stress in CCl4-induced liver damage and the hepato-protective effects mediated by different antioxidants. The present study examined the effects of diphenyl diselenide, (PhSe)2, on hepatotoxicity induced by CCl4 in rats. To this end, male Wistar rats received (PhSe)2 by oral route at the dosage of 31.2 mg/kg for one or two days...
March 2009: Journal of Applied Toxicology: JAT
José Daniel Bosia, María Virginia D'Ascenzo, Silvia Borzi, Susana Cozzi, Jorge Raúl Defelitto, José Oscar Curciarello
The Dubin-Johnson syndrome is a hereditary deficiency in the excretion ofconjugated bilirrubin by hepatocytes characterized by chronic hyperbilirubinemia, alteration in coproporphyrin metabolism, and intracellular deposition of a dark melanin-like pigment giving the liver a typical black cast. We report a 28-year-old male patient who presented conjunctival jaundice and conjugated-hyperbilirubinemia without no other alteration in hepatic biochemistry. The diagnosis of this syndrome was perfomed by using the low-risk methods of laparoscopy-facilitated hepatic biopsy and oral cholecystography In contrast, we avoided the classical Bromsulphalein test because of potential severe side effects...
September 2008: Acta Gastroenterologica Latinoamericana
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