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S Kharchoufi, J Gomez, C Lasanta, R Castro, F Sainz, M Hamdi
BACKGROUND: There is growing interest in the beneficial health effects of certain fruits, such as pomegranate, and their by-products, like vinegar. Vinegars contain antioxidant compounds such as polyphenols, which can scavenge free radicals in the body. In this study, the antioxidant properties (ABTS and DPPH scavenging capacities) and global polyphenolic composition of a new functional product, namely a pomegranate vinegar produced in the laboratory from the Gabsi variety, were evaluated and compared with those of commercial wine vinegars (Sherry and Rioja red wine Spanish vinegars)...
March 15, 2018: Journal of the Science of Food and Agriculture
Ron Shaoul, Dalia Moati, Betty Schwartz, Yulia Pollak, Igor Sukhotnik
BACKGROUND/AIMS: Several studies have demonstrated the antimicrobial, antihelminthic, and antioxidant potential of the active ingredients of pomegranate (PMG) extracts, suggesting their preventive and curative role in several gastrointestinal disorders. In the present study, the authors evaluated the effects of oral PMG supplementation on intestinal structural changes, enterocyte proliferation, and apoptosis during methotrexate (MTX)-induced intestinal damage in a rat. METHODS: Male rats were divided into 4 experimental groups: control rats; CONTR-PMG rats were treated with oral PMG given by gavage once a day 72 hours before and 72 hours following vehicle injection; MTX rats were treated with single dose of methotrexate; and MTX-PMG rats were treated with oral PMG following injection of MTX...
March 13, 2018: Journal of the American College of Nutrition
Bret Cooper, Nazrul Islam, Yunfeng Xu, Hunter S Beard, Wesley M Garrett, Ganyu Gu, Xiangwu Nou
Staphylococcus aureus, a bacterial, food-borne pathogen of humans, can contaminate raw fruits and vegetables. While physical and chemical methods are available to control S. aureus, scientists are searching for inhibitory phytochemicals from plants. One promising compound from pomegranate is punicalagin, a natural antibiotic. To get a broader understanding of the inhibitory effect of punicalagin on S. aureus growth, we used high-throughput mass spectrometry and quantitative isobaric labeling to investigate the proteome of S...
March 12, 2018: Proteomics
Wei Liu, Qi Zhao, Luyang Lv, Suo Yan, Qin Song, Tian Chen, Qian Yao
Pomegranate seed oil (PSO) is primarily composed of unsaturated fatty acids, implying its potential application as a transdermal enhancer. In this study, the function of PSO in prompting the percutaneous absorption of resveratrol was examined and compared with isopropyl palmitate (IP). IP of 10% enhanced the cumulative permeation amount of resveratrol by 50% but did not influence the permeation velocity. Though 2.5% and 5.0% IP accelerated the penetration process of resveratrol, they had no discernable impact on total permeation amount...
March 9, 2018: Journal of Oleo Science
Debarati Chattopadhyay, Kavitha Thirumurugan
Past investigations have shown that various plant extracts are capable of promoting longevity in lower model organisms like Caenorhabditis elegans, Drosophila melanogaster, Saccharomyces cerevisiae, Bombyx mori etc. Longevity studies on such organisms provide a foundation to explore anti-aging efficacies of such plant extracts in higher organisms. Plant extracts of acai palm, apple, asparagus, blueberry, cinnamon, cocoa, Damnacanthus, maize, mistletoe, peach, pomegranate, Rhodiola, rose, Sasa, turmeric, and Withania have extended lifespan in lower model organisms via diverse mechanisms like insulin like growth factor (IGF) signaling pathway, and antioxidant defense mechanisms...
March 8, 2018: Mechanisms of Ageing and Development
Mina Cheraghi Nirumand, Marziyeh Hajialyani, Roja Rahimi, Mohammad Hosein Farzaei, Stéphane Zingue, Seyed Mohammad Nabavi, Anupam Bishayee
Kidney stones are one of the oldest known and common diseases in the urinary tract system. Various human studies have suggested that diets with a higher intake of vegetables and fruits play a role in the prevention of kidney stones. In this review, we have provided an overview of these dietary plants, their main chemical constituents, and their possible mechanisms of action. Camellia sinensis (green tea), Rubus idaeus (raspberry), Rubia cordifolia (common madder), Petroselinum crispum (parsley), Punica granatum (pomegranate), Pistacia lentiscus (mastic), Solanum xanthocarpum (yellow-fruit nightshade), Urtica dioica (stinging nettle), Dolichos biflorus ( horse gram ), Ammi visnaga (khella), Nigella sativa (black-cumin), Hibiscus sabdariffa (roselle), and Origanum vulgare (oregano) have received considerable interest based on scientific evidence...
March 7, 2018: International Journal of Molecular Sciences
Małgorzata Dżugan, Monika Wesołowska, Grzegorz Zaguła, Czesław Puchalski
BACKGROUND: The pomegranate (Punica granatum L.) has gained a reputation as a fruit with many health- promoting properties. It is considered to help prevent or treat various disease risk factors including high blood pressure, high cholesterol, oxidative stress, hyperglycemia and inflammatory activities. It has been demonstrated that certain components of pomegranates, such as polyphenols, have potential antioxidant, anti-inflammatory and anticarcinogenic effects. METHODS: Five commercially available (CA) and three homemade (HM) pomegranate (Puni- ca granatum L...
January 2018: Acta Scientiarum Polonorum. Technologia Alimentaria
Sheng Wu, Li Tian
A new flavone glucoside tricetin 4'-O-β-glucopyranoside (1) and four known ellagitannins and flavones tricetin (2), luteolin (3), ellagic acid (4), and granatin B (5) were isolated from the flowers of Punica granatum L. (Lythraceae). Their structures were established by 1D and 2D NMR as well as mass spectrometry analyses. Among all tested compounds, tricetin (2) exhibited the strongest α-glucosidase inhibitory activity that was comparable to the anti-diabetic drug acarbose. Comparative structure-function analysis of tri-, tetra-, and pentahydroxy flavones [apigenin, luteolin (3), and tricetin (2), respectively] suggested that a greater number of hydroxyl groups on the flavone molecule enhanced its suppression of α-glucosidase, α-amylase, and lipase activities...
March 3, 2018: Natural Product Research
Roman Holic, Yang Xu, Kristian Mark P Caldo, Stacy D Singer, Catherine J Field, Randall J Weselake, Guanqun Chen
Punicic acid (PuA; 18: 3Δ9cis,11trans,13cis ) is an unusual 18-carbon fatty acid bearing three conjugated double bonds. It has been shown to exhibit a myriad of beneficial bioactivities including anti-cancer, anti-diabetes, anti-obesity, antioxidant, and anti-inflammatory properties. Pomegranate (Punica granatum) seed oil contains approximately 80% PuA and is currently the major natural source of this remarkable fatty acid. While both PuA and pomegranate seed oil have been used as functional ingredients in foods and cosmetics for some time, their value in pharmaceutical/medical and industrial applications are presently under further exploration...
March 3, 2018: Applied Microbiology and Biotechnology
María-Teresa García-Conesa, Karen Chambers, Emilie Combet, Paula Pinto, Mar Garcia-Aloy, Cristina Andrés-Lacueva, Sonia de Pascual-Teresa, Pedro Mena, Alekxandra Konic Ristic, Wendy J Hollands, Paul A Kroon, Ana Rodríguez-Mateos, Geoffrey Istas, Christos A Kontogiorgis, Dilip K Rai, Eileen R Gibney, Christine Morand, Juan Carlos Espín, Antonio González-Sarrías
Understanding interindividual variability in response to dietary polyphenols remains essential to elucidate their effects on cardiometabolic disease development. A meta-analysis of 128 randomized clinical trials was conducted to investigate the effects of berries and red grapes/wine as sources of anthocyanins and of nuts and pomegranate as sources of ellagitannins on a range of cardiometabolic risk biomarkers. The potential influence of various demographic and lifestyle factors on the variability in the response to these products were explored...
February 28, 2018: International Journal of Molecular Sciences
Marina Cano-Lamadrid, Krzysztof Lech, Ángel Calín-Sánchez, Ema Carina Rosas-Burgos, Adam Figiel, Aneta Wojdyło, Malwina Wasilewska, Ángel A Carbonell-Barrachina
During the industrial manufacturing of pomegranate juice, large amounts of pomace are produced. The aim of this work was to find the effective method to dry pomegranate pomace to open new commercial applications for this co-product. The effects of three drying methods: (i) convective drying (CD) at 50, 60, and 70 °C; (ii) vacuum microwave drying (VMD) at 240, 360, and 480 W, and (iii) a combined method (CPD-VMFD); convective pre-drying (60 °C) followed by vacuum microwave finish drying (360 W), on drying kinetics and quality of PomP (pomegranate pomace obtained after preparing pomegranate juice by squeezing only arils) were evaluated...
March 2018: Journal of Food Science and Technology
Kuldeep Dhama
BACKGROUND: Punica granatum L (pomegranate), is a shrub mostly available in the Mediterranean Sea region. The fruits have gained the substantial attention among researchers due to its promising biological activities including anti-inflammatory, antibacterial, antidiarrheal, immune modulatory, antitumor, wound healing and antifungal that have been attributed to various constituents of seeds, bark, juice, pericarp and leaf of this tree across the globe. The phenolic compounds of pomegranate have been documented to possess numbers of prophylactic and therapeutic utilities against various pathological infections as well as non-infectious disorders...
February 21, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
Zahra Derakhshan, Margherita Ferrante, Marzieh Tadi, Farnoosh Ansari, Ali Heydari, Motahreh Sadat Hosseini, Gea Oliveri Conti, Elham Khalili Sadarabad
Pomegranate (Punica granatum L.) is extensively cultivated in Middle East especially in Iran. For centuries, this fruit has been used in Iranian herbal medicine. Pomegranate peel, seed and juice contain considerable amounts of phenolic compounds and have antioxidant activity. Pomegranate peels, juice and seeds from three regions of Natanz, Shahreza, and Doorak were obtained. Antioxidant activity, total phenolic, flavonoids, and flavonols contents of pomegranate peels, seeds and juices extracts were analyzed...
February 12, 2018: Food and Chemical Toxicology
José As Souza, Debora B Barbosa, Andresa A Berretta, Jackeline G do Amaral, Luiz F Gorup, Francisco N de Souza Neto, Renan A Fernandes, Gabriela L Fernandes, Emerson R Camargo, Alessandra M Agostinho, Alberto Cb Delbem
AIM: To synthesize, characterize and evaluate the antimicrobial and antibiofilm activities of novel nanocomposites containing silver nanoparticles (AgNPs) associated or not to β-calcium glycerophosphate. MATERIALS & METHODS: These nanocomposites were produced through a 'green' route using extracts of different parts of pomegranate. Antimicrobial and antibiofilm properties against Candida albicans and Streptococcus mutans were determined by the minimum bactericidal/fungicidal concentration and biofilm density after treatments...
February 14, 2018: Future Microbiology
John A Bellone, Jeffrey R Murray, Paolo Jorge, Travis G Fogel, Mary Kim, Desiree R Wallace, Richard E Hartman
OBJECTIVES: We tested whether supplementing with pomegranate polyphenols can enhance cognitive/functional recovery after stroke. METHODS: In this parallel, block-randomized clinical trial, we administered commercially-available pomegranate polyphenol or placebo pills twice per day for one week to adult inpatients in a comprehensive rehabilitation setting starting approximately 2 weeks after stroke. Pills contained 1 g of polyphenols derived from whole pomegranate, equivalent to levels in approximately 8 oz of juice...
February 13, 2018: Nutritional Neuroscience
Emma M Crum, Matthew J Barnes, Stephen R Stannard
Pomegranate extract (POMx) has been suggested as an ergogenic aid, due to its rich concentration of polyphenols, which are proposed to enhance nitric oxide (NO) bioavailability, thereby improving the efficiency of oxygen usage and consequently, endurance exercise performance. Although acute POMx supplementation improves aerobic exercise performance in untrained individuals, trained athletes appear to require chronic supplementation for a similar effect. Further, the combination of POMx with a thiol antioxidant may prove more effective than POMx alone, due to the protective effects of thiols on NO...
February 12, 2018: International Journal of Sport Nutrition and Exercise Metabolism
Tingting Wang, Ruoting Men, Mingxing Hu, Xiaoli Fan, Xiaoxue Yang, Xiaojun Huang, Tinghong Ye, Li Yang
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease of an unknown etiology, glucocorticoid therapy is currently recognized as an effective treatment for AIH, but conventional application and patient compliance are both hindered by its side effects. The exploration of the AIH pathogenesis and the searching for the new candidate drugs that exert potential activity and low toxicity are urgently needed. Pomegranate peel extract (PoPx) is a natural extract of Punica granatum and has been reported to have anti-inflammatory and antioxidative properties...
February 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Flavia Giamogante, Ilaria Marrocco, Laura Cervoni, Margherita Eufemi, Silvia Chichiarelli, Fabio Altieri
BACKGROUND: Polyphenolic compounds isolated from pomegranate fruit possess several pharmacological activities including anti-inflammatory, hepatoprotective, antigenotoxic and anticoagulant activities. The present work focuses the attention on PDIA3 interaction with punicalagin and ellagic acid, the most predominant components of pomegranate extracts. PDIA3, a member of the protein disulfide isomerase family involved in several cellular functions, is associated with different human diseases and it has the potential to be a pharmacological target...
February 6, 2018: Biochimie
Pınar Kadiroğlu
BACKGROUND: The aim of this study was to discriminate commercial apple, rice, balsamic, red wine, rose, white wine, grape and pomegranate vinegars according to antimicrobial activities, total phenolic contents (TPC), antioxidant activities, colour parameters and predict quality characteristics of vinegars using Fourier transform infrared (FTIR) spectroscopy. RESULTS: Results showed that the highest TPC (3971.43±25.00) was found in balsamic vinegar while the lowest TPC was observed in rice vinegar (14...
February 2, 2018: Journal of the Science of Food and Agriculture
Mohammad Reza Amiryousefi, Mohebbat Mohebbi, Ali Tehranifar
Application of new procedures for reliable and fast recognition and classification of seeds in the agricultural industry is very important. Recent advances in computer image analysis made applicable the approach of automated quantitative analysis in order to group cultivars according to minor differences in seed traits that would be indiscernible in ocular inspection. In this work, in order to cluster 20 cultivars of pomegranate seed, nine image features and 21 physicochemical properties of them were extracted...
January 2018: Food Science & Nutrition
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