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https://www.readbyqxmd.com/read/28716598/effect-of-lecithin-nanoliposome-or-soybean-lecithin-supplemented-by-pomegranate-extract-on-post-thaw-flow-cytometric-microscopic-and-oxidative-parameters-in-ram-semen
#1
Mahdieh Mehdipour, Hossein Daghigh Kia, Maryam Nazari, Abouzar Najafi
This investigation was carried out to study the effect of soybean lecithin 1.5% (wt/vol) (0, 2.5, 5 and 7.5 mg l(-1) pomegranate extract (PE)) or PE-loaded lecithin nanoliposome (0, 2.5, 5 and 7.5 mg l(-1)) to Tris-based extender. Sperm motility (CASA), viability, membrane integrity (HOS test), abnormalities, mitochondrial activity, apoptosis status, lipid peroxidation, total antioxidant capacity (TAC)) and antioxidant activities (GPX, SOD) were investigated following freeze-thawing. No significant differences (P < 0...
July 14, 2017: Cryobiology
https://www.readbyqxmd.com/read/28709945/punicalagin-a-polyphenol-from-pomegranate-fruit-induces-growth-inhibition-and-apoptosis-in-human-pc-3-and-lncap-cells
#2
Oluwatosin Adaramoye, Bettina Erguen, Bianca Nitzsche, Michael Höpfner, Klaus Jung, Anja Rabien
Prostate cancer (PCa) is an international health problem and search for its effective treatment is in progress. Punicalagin (PN), polyphenol from pomegranate fruit, is known to exhibit potent anticancer activity in lung, breast and cervical cells. However, there is paucity of information on its effect in PCa. This study evaluated anti-proliferative effects of PN and its effects on extrinsic pathway of apoptosis in PCa cells, and angiogenesis in chicken chorioallantoic membrane (CAM). Antioxidant activities of PN were determined by 2,2-diphenyl-1-picryhydrazyl (DPPH) radical scavenging and inhibition of lipid peroxidation (LPO) methods...
July 11, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28698459/dietary-natural-products-for-prevention-and-treatment-of-breast-cancer
#3
REVIEW
Ya Li, Sha Li, Xiao Meng, Ren-You Gan, Jiao-Jiao Zhang, Hua-Bin Li
Breast cancer is the most common cancer among females worldwide. Several epidemiological studies suggested the inverse correlation between the intake of vegetables and fruits and the incidence of breast cancer. Substantial experimental studies indicated that many dietary natural products could affect the development and progression of breast cancer, such as soy, pomegranate, mangosteen, citrus fruits, apple, grape, mango, cruciferous vegetables, ginger, garlic, black cumin, edible macro-fungi, and cereals. Their anti-breast cancer effects involve various mechanisms of action, such as downregulating ER-α expression and activity, inhibiting proliferation, migration, metastasis and angiogenesis of breast tumor cells, inducing apoptosis and cell cycle arrest, and sensitizing breast tumor cells to radiotherapy and chemotherapy...
July 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28690198/punicalagin-a-ptp1b-inhibitor-induces-m2c-phenotype-polarization-via-up-regulation-of-ho-1-in-murine-macrophages
#4
Xiaolong Xu, Yuhong Guo, Jingxia Zhao, Shasha He, Yan Wang, Yan Lin, Ning Wang, Qingquan Liu
Current data have shown that punicalagin (PUN), an ellagitannin isolated from pomegranate, possesses anti-inflammatory and anti-oxidant properties; however, its direct targets have not yet been reported. This is the first report that PTP1B serves as a direct target of PUN, with IC50 value of 1.04μM. Results from NPOI further showed that the Kon and Koff of PUN-PTP1B complex were 3.38e2M(-1)s(-1) and 4.13e-3s(-1), respectively. The active site Arg24 of PTP1B was identified as a key binding site of PUN by computation simulation and point mutation...
July 8, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28687388/flaxseed-gum-in-combination-with-lemongrass-essential-oil-as-an-effective-edible-coating-for-ready-to-eat-pomegranate-arils
#5
Basharat Yousuf, Abhaya Kumar Srivastava
Flaxseed gum (FSG) in combination with lemongrass essential oil (LGEO) was investigated for coating of ready-to-eat pomegranate arils. FSG was used at 0.3% and 0.6% concentrations and with both concentrations LGEO was incorporated at levels of 0ppm, 200ppm, 500ppm and 800ppm. Changes in headspace gases, physicochemical, microbiological and sensory attributes of pomegranate arils stored at 5°C were studied on different days of analysis during the 12day storage period. Coatings containing LGEO were effective in reducing total plate count and yeast and mold populations...
July 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28670394/pfp-alleviates-nonalcoholic-steatohepatitis-fatty-liver-in-both-apo-e-mice-and-changliver-cell-s
#6
Dong Yan, Yuan-Yuan Wei, Xiu-Mei Li, Xiu-Chao Sun, Zhong Wang, Haji Akber Aisa
High-calorie food leads to nonalcoholic fatty liver disease (NAFLD) through the dysregulation of genes involved in lipid metabolism, but the precise mechanism is still unknown. Pomegranate flowers are used to treat diabetes mellitus in traditional Uighur medicine. Here we sought to investigate the effect and mechanism of pomegranate flower polyphenols (PFP) on NAFLD Apo E(-/-) mice induced by a high-fat diet (HFD) and whether PFP improves NAFLD through decreasing oxidative stress. PFP supplementation in mice significantly reduced the HFD-induced gains in body weight compared with the mice fed only with HFD...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28665969/potentiated-virucidal-activity-of-pomegranate-rind-extract-pre-and-punicalagin-against-herpes-simplex-virus-hsv-when-co-administered-with-zinc-ii-ions-and-antiviral-activity-of-pre-against-hsv-and-aciclovir-resistant-hsv
#7
David M J Houston, Joachim J Bugert, Stephen P Denyer, Charles M Heard
BACKGROUND: There is a clinical need for new therapeutic products against Herpes simplex virus (HSV). The pomegranate, fruit of the tree Punica granatum L, has since ancient times been linked to activity against infection. This work probed the activity of pomegranate rind extract (PRE) and co-administered zinc (II) ions. MATERIALS AND METHODS: PRE was used in conjunction with zinc (II) salts to challenge HSV-1 and aciclovir-resistant HSV in terms of virucidal plaque assay reduction and antiviral activities in epithelial Vero host cells...
2017: PloS One
https://www.readbyqxmd.com/read/28655305/effect-of-pomegranate-extracts-on-brain-antioxidant-markers-and-cholinesterase-activity-in-high-fat-high-fructose-diet-induced-obesity-in-rat-model
#8
Zahra Amri, Asma Ghorbel, Mouna Turki, Férièle Messadi Akrout, Fatma Ayadi, Abdelfateh Elfeki, Mohamed Hammami
BACKGROUND: To investigate beneficial effects of Pomegranate seeds oil (PSO), leaves (PL), juice (PJ) and (PP) on brain cholinesterase activity, brain oxidative stress and lipid profile in high-fat-high fructose diet (HFD) induced-obese rat. METHODS: In vitro and in vivo cholinesterase activity, brain oxidative status, body and brain weight and plasma lipid profile were measured in control rats, HFD-fed rats and HFD-fed rats treated by PSO, PL, PJ and PP. RESULTS: In vitro study showed that PSO, PL, PP, PJ inhibited cholinesterase activity in dose dependant manner...
June 27, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28654223/the-pomegranate-punica-granatum-l-genome-and-the-genomics-of-punicalagin-biosynthesis
#9
Gaihua Qin, Chunyan Xu, Ray Ming, Haibao Tang, Romain Guyot, Elena M Kramer, Yudong Hu, Xingkai Yi, Yongjie Qi, Xiangyang Xu, Zhenghui Gao, Haifa Pan, Jianbo Jian, Yinping Tian, Zhen Yue, Yiliu Xu
Pomegranate (Punica granatum L.) is a perennial fruit crop grown since ancient times that has been planted worldwide and is known for its functional metabolites, particularly punicalagins. We have sequenced and assembled the pomegranate genome with 328 Mb anchored into nine pseudo-chromosomes and annotated 29 229 gene models. A Myrtales lineage-specific whole-genome duplication (WGD) event was detected that occurred in the common ancestor before the divergence of pomegranate and Eucalyptus. Repetitive sequences accounted for 46...
June 27, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28643853/qualitative-analysis-of-polyphenols-in-macroporous-resin-pretreated-pomegranate-husk-extract-by-hplc-qtof-ms
#10
Rahima Abdulla, Sanawar Mansur, Haizhong Lai, Ablikim Ubul, Guangying Sun, Guozheng Huang, Haji Akber Aisa
INTRODUCTION: Pomegranate (Punica granatum L.) husk is a traditional herbal medicine abundant in phenolic compounds and plays some roles in the treatment of oxidative stress, bacterial and viral infection, diabetes mellitus, and acute and chronic inflammation. OBJECTIVE: Identification and determination of polyphenols in macroporous resin pretreated pomegranate husk extract by high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (HPLC-QTOF-MS)...
June 23, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28641022/a-randomized-single-dose-parallel-study-on-enhancement-of-nitric-oxide-in-serum-and-saliva-with-the-use-of-natural-sports-supplement-in-healthy-adults
#11
Joby Jacob, Sreeraj Gopi, Chandradhara Divya
Sports supplements that stimulate the production of nitric oxide (NO) are widely promoted agents in the sports nutrition domain, and nitric oxide plays an important role to enhance the cardiovascular and physical fitness of the sports participants. The purpose of the study is to investigate whether oral intake of a sports nutritional supplement (Fitnox) is able to increase nitrate (NO3(-)) and nitrite (NO2(-)) levels in blood serum and saliva of healthy adults. Fitnox is a unique blend of Kaempferia parviflora methoxy flavones, pomegranate peel polyphenols, and Moringa oleifera leaf saponins...
June 22, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28631823/a-comparative-study-between-labeling-and-reality-the-case-of-phytochemical-composition-of-commercial-pomegranate-based-products
#12
Marina Cano-Lamadrid, Leontina Lipan, Ángel Calín-Sánchez, Francisca Hernández, Ángel A Carbonell-Barrachina
Manufacturers are deeply involved in the development of new pomegranate-based products, which have acquired great prestige due to many studies proving their potential health benefits. Commercial pomegranate products including capsules and supplements and juices and nectars were assayed. The contents of the key phytochemical compounds (punicalagin, ellagic acid, and total polyphenolic content) and the associated antioxidant capacity (DPPH(•) , ABTS(•+) , and FRAP) were analyzed. The experimental ranges of punicalagin and ellagic acid contents were 0...
June 20, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28616977/gastrointestinal-simulation-model-twin-shime-shows-differences-between-human-urolithin-metabotypes-in-gut-microbiota-composition-pomegranate-polyphenol-metabolism-and-transport-along-the-intestinal-tract
#13
Rocío García-Villalba, Hanne Vissenaekens, Judit Pitart, María Romo-Vaquero, Juan C Espín, Charlotte Grootaert, María V Selma, Katleen Raes, Guy Smagghe, Sam Possemiers, John Van Camp, Francisco A Tomas-Barberan
A TWIN-SHIME system was used to compare the metabolism of pomegranate polyphenols by the gut microbiota from two individuals with different urolithin metabotypes. Gut microbiota, ellagitannin metabolism, short-chain fatty acids (SCFA), transport of metabolites, and phase II metabolism using Caco-2 cells were explored. The simulation reproduced the in vivo metabolic profiles for each metabotype. The study shows for the first time that microbial composition, metabolism of ellagitannins, and SCFA differ between metabotypes and along the large intestine...
June 28, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28610446/impacts-of-pulsed-electric-field-and-heat-treatment-on-quality-and-sensory-properties-and-microbial-inactivation-of-pomegranate-juice
#14
Gulsun A Evrendilek
Synergistic effects of pulsed electric field+mild heat on quality properties of pomegranate juice were modeled using the best-fit multiple (non-) linear regression models with inactivation kinetics parameters of Escherichia coli O157:H7 and Staphylococcus aureus. No significant difference was detected between the control and the treated samples in terms of pH; °Brix; total antioxidant capacity; total monomeric anthocyanin content; total ascorbic acid concentration; and the sensory properties of flavor, taste, aftertaste, and overall acceptance ( p > 0...
January 1, 2017: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
https://www.readbyqxmd.com/read/28608832/fruits-for-prevention-and-treatment-of-cardiovascular-diseases
#15
REVIEW
Cai-Ning Zhao, Xiao Meng, Ya Li, Sha Li, Qing Liu, Guo-Yi Tang, Hua-Bin Li
Cardiovascular diseases (CVDs) are leading global health problems. Accumulating epidemiological studies have indicated that consuming fruits was inversely related to the risk of CVDs. Moreover, substantial experimental studies have supported the protective role of fruits against CVDs, and several fruits (grape, blueberry, pomegranate, apple, hawthorn, and avocado) have been widely studied and have shown potent cardiovascular protective action. Fruits can prevent CVDs or facilitate the restoration of morphology and functions of heart and vessels after injury...
June 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28607348/construction-of-sno2-graphene-composite-with-half-supported-cluster-structure-as-anode-toward-superior-lithium-storage-properties
#16
Chengling Zhu, Zhixin Chen, Shenmin Zhu, Yao Li, Hui Pan, Xin Meng, Muhammad Imtiaz, Di Zhang
Inspired by nature, herein we designed a novel construction of SnO2 anodes with an extremely high lithium storage performance. By utilizing small sheets of graphene oxide, the partitioned-pomegranate-like structure was constructed (SnO2@C@half-rGO), in which the porous clusters of SnO2 nanoparticles are partially supported by reduced graphene oxide sheets while the rest part is exposed (half-supported), like partitioned pomegranates. When served as anode for lithium-ion batteries, SnO2@C@half-rGO exhibited considerably high specific capacity (1034...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28603126/prophylactic-and-therapeutic-effect-of-punica-granatum-in-trinitrobenzene-sulfonic-acid-induced-inflammation-in-rats
#17
Azra Riaz, Rafeeq Alam Khan, Syeda Afroz, Neelam Mallick
Pomegranate (Punica granatum L., Punicaceae) contains varieties of antioxidants and phytochemicals; there are evidences that phytochemicals and antioxidants play a vital role in reducing inflammation. Hence this investigation was planned to assess the outcome of Punica granatum on trinitrobenzene sulfonic acid provoked colitis in rats at 2, 5 and 8ml/kg of the body weight. The effect of P. granatum was assessed in two group i.e. prophylaxis as pre-colitis and therapeutic as post-colitis. After completion of dosing in both the groups, macroscopic and histological examination of colon was carried out along with estimation of serum myeloperoxidase, glutathione, alkaline phosphate, fibrinogen and C-reactive protein...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28600209/phytochemical-content-fatty-acids-composition-and-antioxidant-potential-of-different-pomegranate-parts-comparison-between-edible-and-non-edible-varieties-grown-in-tunisia
#18
Zahra Amri, Faten Zaouay, Houda Lazreg-Aref, Hala Soltana, Amira Mneri, Messaoud Mars, Mohamed Hammami
Few comparative studies were interested between edible and non-edible pomegranate varieties. In the present study, flowers, leaves, juice and peel of two pomegranate varieties, ornamental variety "Nana" (NV) and sweet variety "Tounsi" (TV) were compared for their phenolic contents and antioxidant activity. Seeds oils were compared also for their fatty acids (FA) composition.Results showed that peel and juice of NV contained higher content in tannins, Flavonoids and anthocyanins. In contrast, peel and juice of TV were more concentrated in carotenoids and polyphenols...
June 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28597364/potential-application-of-nanoemulsions-for-skin-delivery-of-pomegranate-peel-polyphenols
#19
Thaisa Baccarin, Elenara Lemos-Senna
Pomegranate peel and seeds have demonstrated to possess antioxidant compounds with potential application to protect the skin against the ultraviolet radiation damage. However, the photoprotection activity is dependent on the amount of these compounds that reach the viable skin layers. In this paper, we describe the in vitro skin permeation and retention of the major pomegranate peel polyphenols using Franz diffusion cells, after entrapping a ethyl acetate fraction (EAF) from Punica granatum peel extract into nanoemulsions (NEs) prepared with pomegranate seed oil (PSO) or medium chain triglyceride oil (MCT)...
June 8, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28594931/de-novo-transcriptome-assembly-and-quantification-reveal-differentially-expressed-genes-between-soft-seed-and-hard-seed-pomegranate-punica-granatum-l
#20
Hui Xue, Shangyin Cao, Haoxian Li, Jie Zhang, Juan Niu, Lina Chen, Fuhong Zhang, Diguang Zhao
Pomegranate (Punica granatum L.) belongs to Punicaceae, and is valued for its social, ecological, economic, and aesthetic values, as well as more recently for its health benefits. The 'Tunisia' variety has softer seeds and big arils that are easily swallowed. It is a widely popular fruit; however, the molecular mechanisms of the formation of hard and soft seeds is not yet clear. We conducted a de novo assembly of the seed transcriptome in P. granatum L. and revealed differential gene expression between the soft-seed and hard-seed pomegranate varieties...
2017: PloS One
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