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https://www.readbyqxmd.com/read/29121593/stimulation-of-liver-igf-1-expression-promotes-peak-bone-mass-achievement-in-growing-rats-a-study-with-pomegranate-seed-oil
#1
Deepa Bachagol, Gilbert Stanley Joseph, Govindraj Ellur, Kalpana Patel, Pamisetty Aruna, Monika Mittal, Shyamsundar Pal China, Ravendra Pratap Singh, Kunal Sharan
Peak bone mass (PBM) achieved at adulthood is a strong determinant of future onset of osteoporosis, and maximizing it is one of the strategies to combat the disease. Recently, pomegranate seed oil (PSO) has been shown to have bone-sparing effect in ovariectomized mice. However, its effect on growing skeleton and its molecular mechanism remain unclear. In the present study, we evaluated the effect of PSO on PBM in growing rats and associated mechanism of action. PSO was given at various doses to 21-day-old growing rats for 90 days by oral gavage...
October 12, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29120809/formulation-and-characterization-of-novel-nanostructured-lipid-carriers-made-from-beeswax-propolis-wax-and-pomegranate-seed-oil
#2
Yasamin Soleimanian, Sayed Amir Hossein Goli, Jaleh Varshosaz, Sayed Mohammad Sahafi
The objective of this study was to develop functional nanostructured lipid carriers (NLCs) using beeswax (BW), propolis wax (PW) and pomegranate seed oil (PSO). NLCs were prepared by a melt emulsification-ultra sonication technique. The influences of solid lipid composition, surfactant blend concentration (2, 4, and 6% of formulation) and PSO content (10, 30 and 50% of total lipid phase) were investigated. Statistical evaluations revealed that the formulation variables had significant effects on physical properties of NLC...
April 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29109097/role-of-melt-curve-analysis-in-interpretation-of-nutrigenomics-microrna-expression-data
#3
Farid E Ahmed, Mostafa M Gouda, Laila A Hussein, Nancy C Ahmed, Paul W Vos, Mahmoud A Mohammad
This article illustrates the importance of melt curve analysis (MCA) in interpretation of mild nutrogenomic micro(mi)RNA expression data, by measuring the magnitude of the expression of key miRNA molecules in stool of healthy human adults as molecular markers, following the intake of Pomegranate juice (PGJ), functional fermented sobya (FS), rich in potential probiotic lactobacilli, or their combination. Total small RNA was isolated from stool of 25 volunteers before and following a three-week dietary intervention trial...
November 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/29105385/punica-granatum-l-fruit-aqueous-extract-suppresses-reactive-oxygen-species-mediated-p53-p65-mir-145-expressions-followed-by-elevated-levels-of-irs-1-in-alloxan-diabetic-rats
#4
Ehsan Gharib, Shideh Montasser Kouhsari, Maryam Izad
OBJECTIVES: Reactive oxygen species (ROS) is an apoptosis inducer in pancreatic β-cells that stimulates p53/p65 mediated microRNA (miR)-145 expression. Punica granatum L. (pomegranate) is an antioxidant fruit that attenuates ROS generation. This study examines the effects of pomegranate fruit aqueous extract (PGE) on the levels of ROS, p53, p65, miR-145, and its target insulin receptor substrate 1 (irs-1) mRNA in Alloxan-diabetic male Wistar rats. MATERIALS AND METHODS: In this experimental study, diabetic rats received different doses of PGE...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29103458/pomegranate-leaf-attenuates-lipid-absorption-in-the-small-intestine-in-hyperlipidemic-mice-by-inhibiting-lipase-activity
#5
Xuan Yu, Xin-Pei Wang, Fan Lei, Jing-Fei Jiang, Jun Li, Dong-Ming Xing, Li-Jun DU
Pomegranate leaf (PGL) has a definite role in regulating lipid metabolism. However, pharmacokinetic results show the main active ingredient, ellagic acid, in PGL has lower oral bioavailability, suggesting that the lipid-lowering effect of PGL may act through inhibiting lipid absorption in the small intestine. Our results demonstrated that pomegranate leaf and its main active ingredients (i.e., ellagic acid, gallic acid, pyrogallic acid and tannic acid) were capable of inhibiting pancreatic lipase activity in vitro...
October 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29098640/effect-of-genotype-on-the-sprouting-of-pomegranate-punica-granatum-l-seeds-as-a-source-of-phenolic-compounds-from-juice-industry-by-products
#6
Beatrice Falcinelli, Ombretta Marconi, Stefano Maranghi, Stanley Lutts, Adolfo Rosati, Franco Famiani, Paolo Benincasa
Pomegranate (Punica granatum L.) fruits are used mainly by the juice industry, for which seeds are a by-product to be disposed of, though they could potentially be a source of bioactive compounds. In this work, germination (total germination percentage, G; mean germination time, MGT; time to reach 80% of germination, TG80; seedling shoot length, fresh weight and dry matter), and nutritional value (total phenolics, TP; total flavonoids, TF; total non-tannins, TNT; antioxidant activities) of pomegranate seeds and sprouts were determined on four commercial pomegranate cultivars (Akko, Dente di Cavallo, Mollar de Elche and Wonderful)...
November 2, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29096741/effect-of-pomegranate-punica-granatum-l-juice-on-kidney-liver-heart-and-testis-histopathological-changes-and-the-tissues-lipid-peroxidation-and-antioxidant-status-in-lead-acetate-treated-rats
#7
D S Aksu, Y S Sağlam, S Yildirim, T Aksu
Pomegranate juice (PJ) contains relevant amounts of active biological compounds which alleviate the detrimental effects of chronic heavy metal exposure. This study investigated the protective potential of PJ against lead-induced oxidative stress. A total of forty adult male Sprague Dawley rats were divided into four experimental groups. The animals were fed a standard pellet diet and tap water ad libitum. The rats were divided into four groups (n=10 for each group): control, lead asetat (2000 ppm), low-treated PJ- a daily dose of 2...
October 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29076245/highly-selective-and-efficient-imprinted-polymers-based-on-carboxyl-functionalized-magnetic-nanoparticles-for-the-extraction-of-gallic-acid-from-pomegranate-rind
#8
Junjie Zhang, Benqiang Li, Huijuan Yue, Jing Wang, Yuansuo Zheng
With the combined surface imprinting technique and immobilized template strategy, molecularly imprinted magnetic nanoparticles were successfully prepared and coupled with high-performance liquid chromatography to selectively separate and determine gallic acid from the pomegranate rind. On the surface of carboxyl-functionalized magnetic nanospheres, thin imprinting shells were formed using dopamine as monomer and crosslinker. The characteristics, polymerization conditions, and adsorption performances of the resultant nanomaterials were investigated in detail...
October 27, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29071778/isolation-of-ellagic-acid-from-pomegranate-peel-extract-by-hydrophobic-interaction-chromatography-using-graphene-oxide-grafted-cotton-fiber-adsorbent
#9
Rong Peng, Qijiayu Wu, Jingling Chen, Raja Ghosh, Xiaonong Chen
Ellagic acid, a natural polyphenol, was isolated from pomegranate peel extract by hydrophobic interaction using graphene oxide grafted cotton fiber as a stationary adsorbent. The grafted graphene oxide moieties served as hydrophobic interaction binding sites for ellagic acid adsorption. The graphene oxide grafted cotton fiber was made into a membrane-like sheet in order to complete ellagic acid purification by using a binding-elution mode. The effects of operational parameters, such as the composition of the binding buffer/elution buffer, buffer pH and buffer concentration, on the isolation process were investigated...
October 26, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29045641/genetic-variability-of-two-leaffooted-bugs-leptoglossus-clypealis-and-leptoglossus-zonatus-hemiptera-coreidae-in-the-central-valley-of-california
#10
A L Joyce, B S Higbee, D R Haviland, H Brailovsky
Leaffooted plant bugs (LFPBs) (Leptoglossus spp., Guérin-Méneville) (Hemiptera: Coreidae) are large seed-feeding bugs native to the Western Hemisphere. In California, several Leptoglossus spp. feed on almonds, pistachios, and pomegranate and are occasional pests. The objective of this study was to survey the different species of Leptoglossus present in almond, pistachio, and pomegranate orchards in the Central Valley of California. We used two molecular markers, amplified fragment length polymorphisms (AFLPs) and mitochondrial DNA COI, to determine the number of species or strains of each species, and to infer whether individuals of each species move and possibly interbreed with populations from the other host plants...
October 16, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29028333/profiling-and-quantification-of-regioisomeric-caffeoyl-glucoses-in-berry-fruits
#11
Maria Alexandra Patras, Nikolai Kuhnert, Rakesh Jaiswal, Gordon J McDougall
Based on a recently developed tandem MS based hierarchical scheme for the identification of regioisomeric caffeoyl glucoses, selected berry fruits were profiled for their caffeoyl glucose ester content. Fresh edible berries profiled included strawberries, raspberries, blueberries, blackberries, red and black currants, lingonberries, gooseberries, cranberries, juice of elderberries, goji berries, chokeberries, cranberries, açai berries, sea buckthorn berries, Montmorency sour cherries, and pomegranate were investigated...
October 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29027276/natural-medicines-for-acute-renal-failure-a-review
#12
REVIEW
Motahareh Boozari, Hossein Hosseinzadeh
Acute renal failure (ARF) is a life-threating disease with high mortality percentage. Two important mechanisms of ARF are inflammation and oxidative stress. Plants are rich source of antioxidant compounds and have a strong anti-inflammatory activity, so they may be useful for the treatment of ARF. Some herbal medicines are effective against different models of experimentally induced ARF such as cisplatin, gentamicin, glycerol, and ischemia-reperfusion injury. Some of these plants such as ginseng, black seed, ginger, garlic, grape, pomegranate, saffron, and green tea are so famous and are effective against various models of ARF...
October 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29021286/pomegranate-juice-but-not-an-extract-confers-a-lower-glycemic-response-on-a-high-glycemic-index-food-randomized-crossover-controlled-trials-in-healthy-subjects
#13
Asimina Kerimi, Hilda Nyambe-Silavwe, Julia S Gauer, Francisco A Tomás-Barberán, Gary Williamson
Background: Low-glycemic index diets have demonstrated health benefits associated with a reduced risk of developing type 2 diabetes.Objectives: We tested whether pomegranate polyphenols could lower the glycemic response of a high-glycemic index food when consumed together and the mechanism by which this might occur.Design: We compared the acute effect of a pomegranate juice and a polyphenol-rich extract from pomegranate (supplement) on the bread-derived postprandial blood glucose concentration in 2 randomized, crossover, controlled studies (double-blinded for the supplements), each on 16 healthy volunteers...
October 11, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28990942/-herbal-supplement-usage-in-cardiac-patients
#14
Neslihan Pınar, Meyli Topaloğlu, Cahit Özer, Harun Alp
OBJECTIVE: Complementary and alternative medicine (CAM) has become more and more widespread around the world. CAM is a broad term that refers to all medical healthcare services, methods, and practices that are not part of standard medical care, as well as the accompanying theories and beliefs. The aim of the present study was to investigate the use of herbal medicinal products in cardiac patients, as well as the methods of administration of the products. METHODS: This descriptive cross-sectional study included 199 patients aged over 18 years who were hospitalized in the Defne Hospital department of cardiology and volunteered to participate in a 20-item survey between April 2016 and June 2016...
October 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28989248/potential-antitumor-effects-of-pomegranates-and-its-ingredients
#15
REVIEW
Arshad H Rahmani, Mohammed A Alsahli, Saleh A Almatroodi
The treatment based on plant or plant derivatives is a promising strategy in the killing of cancers cells. Moreover, wide-ranging finding has established that medicinal plant and its ingredient modulate several cells signaling pathways or inhibiting the carcinogenesis process. In this vista, pomegranates fruits, seeds and peels illustrate cancer preventive role seems to be due to rich source of antioxidant and other valuable ingredients. Furthermore, anti-tumour activities of pomegranates have been evidences through the modulation of cell signaling pathways including transcription factor, apoptosis and angiogenesis...
July 2017: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/28987497/optimization-of-a-new-method-for-extraction-of-cyanidin-chloride-and-pelargonidin-chloride-anthocyanins-with-magnetic-solid-phase-extraction-and-determination-in-fruit-samples-by-hplc-with-central-composite-design
#16
Abdollah Yari, Saba Rashnoo
Here, we are reporting a sensitive, simple and rapid method for the analysis of cyanidin chloride and pelargonidin chloride anthocyanins in cherry, sour cherry, pomegranate and barberry produced in Iran. The analytes were extracted with acetonitrile-hydrochloric acid (1% v/v) mixture under optimized pretreatment conditions. Clean-up of the extract from fruits was conducted by magnetic solid phase extraction using salicylic acid functionalized silica-coated magnetite nanoparticles (SCMNPs) as the adsorbent. The optimized conditions searched with central composite design...
November 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28985741/lack-of-efficacy-of-pomegranate-supplementation-for-glucose-management-insulin-levels-and-sensitivity-evidence-from-a-systematic-review-and-meta-analysis
#17
Haohai Huang, Dan Liao, Guangzhao Chen, Honglang Chen, Yongkun Zhu
BACKGROUND: The potential glucose-lowering effects of pomegranate have been reported in animal and observational studies, but intervention studies in humans have generated mixed results. In this paper, we aimed to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the precise effects of pomegranate supplementation on measures of glucose control, insulin levels and insulin sensitivity in humans. METHODS: Comprehensive electronic searches were conducted in PubMed, Embase, and the Cochrane Library...
October 6, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28976208/pomegranate-extract-alters-breast-cancer-stem-cell-properties-in-association-with-inhibition-of-epithelial-to-mesenchymal-transition
#18
Sameera Nallanthighal, Kristine M Elmaliki, Ramune Reliene
Cancer stem cells (CSCs) have become an important target population in cancer therapy and prevention due to their ability to self-renew, initiate tumors, and resist therapy. We examined whether pomegranate extract (PE) alters characteristics of breast CSCs. Ability to grow as mammospheres is a hallmark of breast CSCs. PE inhibited mammosphere formation in two different cell lines, neoplastic mammary epithelial HMLER and breast cancer Hs578T. In addition, mammosphere-derived cells from PE treatment groups showed reduced mammosphere formation for at least two serial passages...
October 4, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28961988/field-attraction-of-carob-moth-to-host-plants-and-conspecific-females
#19
Seyed Ali Hosseini, Seyed Hossein Goldansaz, Steph B J Menken, Michiel van Wijk, Peter Roessingh, Astrid T Groot
The carob moth, Ectomyelois ceratoniae (Zeller; Lepidoptera: Pyralidae), is a devastating pest in high-value crops around the world. An efficient sex pheromone attractant is still missing for the management of this pest, because the major pheromone component is unstable. Host plant volatiles attract herbivore insects and have shown to have good potential to be exploited as alternatives or supplements to sex pheromones. To explore this possibility in carob moth, we assessed the attraction of moths to the volatiles of mature pistachio and different fruit stages of pomegranate, alone and in combination with virgin females, using sticky delta traps in pomegranate orchards of Iran...
September 6, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28961447/on-line-monitoring-of-aspergillus-niger-gh1-growth-in-a-bioprocess-for-the-production-of-ellagic-acid-and-ellagitannase-by-solid-state-fermentation
#20
Pedro Aguilar-Zárate, Jorge E Wong-Paz, Luis V Rodríguez-Duran, Juan Buenrostro-Figueroa, Mariela Michel, Gerardo Saucedo-Castañeda, Ernesto Favela-Torres, Juan A Ascacio-Valdés, Juan C Contreras-Esquivel, Cristóbal N Aguilar
The present work describes the monitoring of CO2 production by Aspergillus niger GH1 in a bioprocess for the production of ellagitannase (EAH) and ellagic acid by solid state fermentation. Pomegranate ellagitannins, mainly punicalagin, were used as carbon source and EAH inducer. A second condition, using ellagitannins and maltose as growth promoting carbon source, was tested. The ellagic acid production was quantified and the EAH activity was assayed. The accumulated metabolites were identified by HPLC-ESI-MS/MS...
September 20, 2017: Bioresource Technology
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