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Hosung Kim, Ji-Hoon Kim, Katherine L Possin, Joseph Winer, Michael D Geschwind, Duan Xu, Christopher P Hess
In patients with premotor Huntington's disease (pmHD), literature has reported decreases in caudate volume. However, the regional vulnerability of the caudate nucleus to pmHD remains to be clarified. We aimed to determine whether regional structural damage of the caudate nucleus was present in pmHD and was correlated with clinical profile using a surface-based morphometric technique applied to T1-weighted MRI. The study cohort consisted of 14 volunteers with genetically confirmed pmHD (6 males; 41.8 ± 13...
October 11, 2016: Brain Imaging and Behavior
Tung Nguyen, Ceib Phillips, Beatriz Paniagua
OBJECTIVE: To introduce new 3-D imaging techniques to characterize shape and volume changes of the oropharyngeal space after bilateral sagittal split osteotomy (BSSO) advancement. MATERIALS AND METHODS: Longitudinal cone-beam computed tomography (CBCT) scans were obtained for 20 patients undergoing BSSO advancement at three time points (T1 = presurgery, T2 = splint removal, and T3 = 1 year after surgery). Segmentation of the airway was performed using the following boundaries: hard palate/posterior nasal spine superiorly and lower border of C3 to the base of the epiglottis inferiorly...
May 3, 2016: Angle Orthodontist
Liliane Rosas Gomes, Marcelo Regis Gomes, João Roberto Gonçalves, Antônio Carlos O Ruellas, Larry M Wolford, Beatriz Paniagua, Erika Benavides, Lúcia Helena Soares Cevidanes
OBJECTIVE: To quantitatively compare condylar morphology using cone beam computed tomography (CBCT) and multislice spiral computed tomography (MSCT) virtual three-dimensional surface models. STUDY DESIGN: The sample consisted of secondary data analyses of CBCT and MSCT scans obtained for clinical purposes from 74 patients treated with condylar resection and prosthetic joint replacement. Three-dimensional surface models of 146 condyles were constructed from each scan modality...
January 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Alexandra Kammen, Meng Law, Bosco S Tjan, Arthur W Toga, Yonggang Shi
Diffusion MRI tractography provides a non-invasive modality to examine the human retinofugal projection, which consists of the optic nerves, optic chiasm, optic tracts, the lateral geniculate nuclei (LGN) and the optic radiations. However, the pathway has several anatomic features that make it particularly challenging to study with tractography, including its location near blood vessels and bone-air interface at the base of the cerebrum, crossing fibers at the chiasm, somewhat-tortuous course around the temporal horn via Meyer's Loop, and multiple closely neighboring fiber bundles...
January 15, 2016: NeuroImage
Aline M da S Braga, Elaine K Fujisao, Roberto C Verdade, Rômulo P Paschoalato, Ricardo P Paschoalato, Seizo Yamashita, Luiz E Betting
OBJECTIVE: Studies using quantitative neuroimaging have shown subtle abnormalities in patients with idiopathic generalized epilepsy (IGE). These findings have several locations, but the midline parasagittal structures are most commonly implicated. The cingulate cortex is related and may be involved. The objective of the current investigation was to perform a comprehensive analysis of the cingulate cortex using multiple quantitative structural neuroimaging techniques. METHODS: Thirty-two patients (18 women, 30 ± 10 years) and 36 controls (18 women, 32 ± 11 years) were imaged by 3 Tesla magnetic resonance imaging (MRI)...
November 2015: Epilepsia
Liliane R Gomes, Marcelo Gomes, Bryan Jung, Beatriz Paniagua, Antonio C Ruellas, João Roberto Gonçalves, Martin A Styner, Larry Wolford, Lucia Cevidanes
This study aimed to investigate imaging statistical approaches for classifying three-dimensional (3-D) osteoarthritic morphological variations among 169 temporomandibular joint (TMJ) condyles. Cone-beam computed tomography scans were acquired from 69 subjects with long-term TMJ osteoarthritis (OA), 15 subjects at initial diagnosis of OA, and 7 healthy controls. Three-dimensional surface models of the condyles were constructed and SPHARM-PDM established correspondent points on each model. Multivariate analysis of covariance and direction-projection-permutation (DiProPerm) were used for testing statistical significance of the differences between the groups determined by clinical and radiographic diagnoses...
July 2015: Journal of Medical Imaging
Matthew D Macfarlane, David Jakabek, Mark Walterfang, Susanna Vestberg, Dennis Velakoulis, Fiona A Wilkes, Christer Nilsson, Danielle van Westen, Jeffrey C L Looi, Alexander Frizell Santillo
INTRODUCTION: Behavioural variant frontotemporal dementia (bvFTD) is associated with changes in dorsal striatal parts of the basal ganglia (caudate nucleus and putamen), related to dysfunction in the cortico-striato-thalamic circuits which help mediate executive and motor functions. We aimed to determine whether the size and shape of striatal structures correlated with diagnosis of bvFTD, and measures of clinical severity, behaviour and cognition. MATERIALS AND METHODS: Magnetic resonance imaging scans from 28 patients with bvFTD and 26 healthy controls were manually traced using image analysis software (ITK-SNAP)...
2015: PloS One
A Pasha Hosseinbor, Moo K Chung, Cheng Guan Koay, Stacey M Schaefer, Carien M van Reekum, Lara Peschke Schmitz, Matt Sutterer, Andrew L Alexander, Richard J Davidson
Image-based parcellation of the brain often leads to multiple disconnected anatomical structures, which pose significant challenges for analyses of morphological shapes. Existing shape models, such as the widely used spherical harmonic (SPHARM) representation, assume topological invariance, so are unable to simultaneously parameterize multiple disjoint structures. In such a situation, SPHARM has to be applied separately to each individual structure. We present a novel surface parameterization technique using 4D hyperspherical harmonics in representing multiple disjoint objects as a single analytic function, terming it HyperSPHARM...
May 2015: Medical Image Analysis
Rosita Shishegar, Joanne M Britto, Leigh A Johnston
The cerebral cortex is folded into gyri and sulci in the brains of higher mammals. Quantitative study of the process by which the cortex folds during brain development is critical to a complete understanding of normal brain development and neuro-developmental disorders. In this work, we propose a new method by which to localise nonlinearities in the cortical folding process, and thereby identify regions of differential growth across the cortex. Our method is based on spherical harmonic (SPHARM) representation of the cortical surface...
2014: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Jaeil Kim, Maria Del C Valdes-Hernandez, Natalie A Royle, Jinah Park
Accurately recovering the hippocampal shapes against rough and noisy segmentations is as challenging as achieving good anatomical correspondence between the individual shapes. To address these issues, we propose a mesh-to-volume registration approach, characterized by a progressive model deformation. Our model implements flexible weighting scheme for model rigidity under a multi-level neighborhood for vertex connectivity. This method induces a large-to-small scale deformation of a template surface to build the pairwise correspondence by minimizing geometric distortion while robustly restoring the individuals' shape characteristics...
June 2015: IEEE Transactions on Medical Imaging
Shan Cong, Maher Rizkalla, Eliza Y Du, John West, Shannon Risacher, Andrew Saykin, Li Shen
The hippocampus is widely studied with neuroimaging techniques given its importance in learning and memory and its potential as a biomarker for brain disorders such as Alzheimer's disease and epilepsy. However, its complex folding anatomy often presents analytical challenges. In particular, the critical hippocampal subfield information is usually ignored by hippocampal registration in detailed morphometric studies. Such an approach is thus inadequate to accurately characterize hippocampal morphometry and effectively identify hippocampal structural changes related to different conditions...
August 2014: ... Midwest Symposium on Circuits and Systems Conference Proceedings: MWSCAS
Francesco Ciompi, Colin Jacobs, Ernst Th Scholten, Mathilde M W Wille, Pim A de Jong, Mathias Prokop, Bram van Ginneken
We present a novel descriptor for the characterization of pulmonary nodules in computed tomography (CT) images. The descriptor encodes information on nodule morphology and has scale-invariant and rotation-invariant properties. Information on nodule morphology is captured by sampling intensity profiles along circular patterns on spherical surfaces centered on the nodule, in a multi-scale fashion. Each intensity profile is interpreted as a periodic signal, where the Fourier transform is applied, obtaining a spectrum...
April 2015: IEEE Transactions on Medical Imaging
Ameer Pasha Hosseinbor, Won Hwa Kim, Nagesh Adluru, Amit Acharya, Houri K Vorperian, Moo K Chung
Recently, the HyperSPHARM algorithm was proposed to parameterize multiple disjoint objects in a holistic manner using the 4D hyperspherical harmonics. The HyperSPHARM coefficients are global; they cannot be used to directly infer localized variations in signal. In this paper, we present a unified wavelet framework that links Hyper-SPHARM to the diffusion wavelet transform. Specifically, we will show that the HyperSPHARM basis forms a subset of a wavelet-based multiscale representation of surface-based signals...
2014: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
Nicolas Carriere, Pierre Besson, Kathy Dujardin, Alain Duhamel, Luc Defebvre, Christine Delmaire, David Devos
Apathy is characterized by lack of interest, loss of initiative, and flattening of affect. It is a frequent, very disabling nonmotor complication of Parkinson's disease (PD). The condition may notably occur when dopaminergic medications are tapered after the initiation of subthalamic stimulation and thus can be referred to as "dopaminergic apathy." Even in the absence of tapering, some patients may develop a form of apathy as PD progresses. This form is often related to cognitive decline and does not respond to dopaminergic medications (dopa-resistant apathy)...
June 2014: Movement Disorders: Official Journal of the Movement Disorder Society
Ameer Pasha Hosseinbor, Moo K Chung, Stacey M Schaefer, Carien M van Reekum, Lara Peschke-Schmitz, Matt Sutterer, Andrew L Alexander, Richard J Davidson
We present a novel surface parameterization technique using hyperspherical harmonics (HSH) in representing compact, multiple, disconnected brain subcortical structures as a single analytic function. The proposed hyperspherical harmonic representation (HyperSPHARM) has many advantages over the widely used spherical harmonic (SPHARM) parameterization technique. SPHARM requires flattening 3D surfaces to 3D sphere which can be time consuming for large surface meshes, and can't represent multiple disconnected objects with single parameterization...
2013: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
Beatriz Paniagua, Omri Emodi, Jonathan Hill, James Fishbaugh, Luiz A Pimenta, Stephen R Aylward, Enquobahrie Andinet, Guido Gerig, John Gilmore, John A van Aalst, Martin Styner
The skull of young children is made up of bony plates that enable growth. Craniosynostosis is a birth defect that causes one or more sutures on an infant's skull to close prematurely. Corrective surgery focuses on cranial and orbital rim shaping to return the skull to a more normal shape. Functional problems caused by craniosynostosis such as speech and motor delay can improve after surgical correction, but a post-surgical analysis of brain development in comparison with age-matched healthy controls is necessary to assess surgical outcome...
March 29, 2013: Proceedings of SPIE
Srilakshmi M Adhyapak, Prahlad G Menon, V Rao Parachuri
OBJECTIVES: Several issues that are inherent in the surgical techniques of surgical ventricular restoration (SVR) need specialized devices or techniques to overcome them, which may not always result in optimal outcomes. We used a non-invasive novel in silico modelling technique to study left ventricular (LV) morphology and function before and after SVR. The cardiac magnetic resonance imaging derived actual pre- and postoperative endocardial morphology and function was compared with the in silico analysis of the same...
February 2014: Interactive Cardiovascular and Thoracic Surgery
Cheng-Jin Du, Phillip T Hawkins, Len R Stephens, Till Bretschneider
BACKGROUND: Fundamental cellular processes such as cell movement, division or food uptake critically depend on cells being able to change shape. Fast acquisition of three-dimensional image time series has now become possible, but we lack efficient tools for analysing shape deformations in order to understand the real three-dimensional nature of shape changes. RESULTS: We present a framework for 3D+time cell shape analysis. The main contribution is three-fold: First, we develop a fast, automatic random walker method for cell segmentation...
2013: BMC Bioinformatics
Beatriz Paniagua, Lucile Bompard, Josh Cates, Ross Whitaker, Manasi Datar, Clement Vachet, Martin Styner
DESCRIPTION OF PURPOSE: The NA-MIC SPHARM-PDM Toolbox represents an automated set of tools for the computation of 3D structural statistical shape analysis. SPHARM-PDM solves the correspondence problem by defining a first order ellipsoid aligned, uniform spherical parameterization for each object with correspondence established at equivalently parameterized points. However, SPHARM correspondence has shown to be inadequate for some biological shapes that are not well described by a uniform spherical parameterization...
March 23, 2012: Proceedings of SPIE
Beatriz Paniagua, Amanda Lyall, Jean-Baptiste Berger, Clement Vachet, Robert M Hamer, Sandra Woolson, Weili Lin, John Gilmore, Martin Styner
Statistical shape analysis has emerged as an insightful method for evaluating brain structures in neuroimaging studies, however most shape frameworks are surface based and thus directly depend on the quality of surface alignment. In contrast, medial descriptions employ thickness information as alignment-independent shape metric. We propose a joint framework that computes local medial thickness information via a mean latitude axis from the well-known spherical harmonic (SPHARM-PDM) shape framework. In this work, we applied SPHARM derived medial representations to the morphological analysis of lateral ventricles in neonates...
March 29, 2013: Proceedings—Society of Photo-Optical Instrumentation Engineers
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