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https://www.readbyqxmd.com/read/29231872/a-deeper-examination-of-thorellius-atrox-scorpion-venom-components-with-omic-techonologies
#1
Teresa Romero-Gutierrez, Esteban Peguero-Sanchez, Miguel A Cevallos, Cesar V F Batista, Ernesto Ortiz, Lourival D Possani
This communication reports a further examination of venom gland transcripts and venom composition of the Mexican scorpion Thorellius atrox using RNA-seq and tandem mass spectrometry. The RNA-seq, which was performed with the Illumina protocol, yielded more than 20,000 assembled transcripts. Following a database search and annotation strategy, 160 transcripts were identified, potentially coding for venom components. A novel sequence was identified that potentially codes for a peptide with similarity to spider ω-agatoxins, which act on voltage-gated calcium channels, not known before to exist in scorpion venoms...
December 12, 2017: Toxins
https://www.readbyqxmd.com/read/29229899/phenotypic-variation-in-patients-with-homozygous-c-1678g-t-mutation-in-evc-gene-report-of-two-mexican-families-with-ellis-van-creveld-syndrome
#2
Marisol Ibarra-Ramirez, Luis Daniel Campos-Acevedo, Jose Lugo-Trampe, Laura E Martínez-Garza, Víctor Martinez-Glez, María Valencia-Benitez, Pablo Lapunzina, Víctor Ruiz-Peréz
BACKGROUND Ellis-van Creveld syndrome is an autosomal recessive chondro-ectodermal dysplasia characterized by disproportionate short stature, limb shortening, narrow chest, postaxial polydactyly and dysplastic nails and teeth. In addition, 60% of cases present congenital heart defects. Ellis-van Creveld syndrome is predominantly caused by mutations in the EVC or EVC2 (4p16) genes, with only a few cases caused by mutations in WDR35.  CASE REPORT Here, we report on two Mexican families with patients diagnosed with Ellis-van Creveld syndrome...
December 12, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29228962/decision-making-on-therapeutic-futility-in-mexican-adolescents-with-cancer-a-qualitative-study
#3
Carlo Egysto Cicero-Oneto, Edith Valdez-Martinez, Miguel Bedolla
BACKGROUND: The world literature shows that empirical research regarding the process of decision-making when cancer in adolescents is no longer curable has been conducted in High-income, English speaking countries. The objective of the current study was to explore in-depth and to explain the decision-making process from the perspective of Mexican oncologists, parents, and affected adolescents and to identify the ethical principles that guide such decision-making. METHODS: Purposive, qualitative design based on individual, fact-to-face, semi-structured, in-depth interviews...
December 11, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/29228552/social-demographics-health-behaviors-and-telomere-length-in-the-mexican-american-mano-a-mano-cohort
#4
Hua Zhao, Lixia Han, David Chang, Yuanqing Ye, Jie Shen, Carrie R Daniel, Jian Gu, Wong-Ho Chow, Xifeng Wu
In the current study, we examined cross-sectional associations among social-demographics, lifestyle behaviors, and relative telomere length (RTL) in peripheral blood leukocytes, as well as longitudinal relationships among major chronic diseases, weight gain, and RTL, among 12,792 Mexican Americans aged 20 to 85 years in the Mano-A-Mano, the Mexican American Cohort. As expected, RTL was inversely correlated with age (ρ=-0.15, ρ<0.001). In the multivariate analysis, we found that RTL was positively correlated with levels of education (ρ=0...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29226140/prevalence-of-helicobacter-pylori-vaca-genotypes-and-caga-gene-in-dental-plaque-of-asymptomatic-mexican-children
#5
Alejandra Mendoza-Cantú, Víctor Hugo Urrutia-Baca, Cynthia Sofía Urbina-Ríos, Myriam Angélica De la Garza-Ramos, Martha Elena García-Martínez, Hilda H H Torre-Martínez
The variability in Helicobacter pylori vacA and cagA genes has been related to the progression of the gastrointestinal disease; also the presence of H. pylori in the oral cavity has been associated with periodontal disease in adults, but, in children without dyspeptic symptoms, little is known about this. We evaluated the prevalence of H. pylori and the presence of vacA/cagA genotypes in the oral cavity of Mexican children without dyspeptic symptoms. The gingival status was measured, and dental plaque samples (n = 100) were taken...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29225446/use-of-internet-for-general-and-dental-health-along-acculturation-features-in-a-sample-of-mexican-americans
#6
Odette Aguirre, Rodrigo Mariño, Carlo Medina-Solís, Gerardo Maupomé
The objectives of this study were to explore self-reported Internet and electronic platforms used to search for and store medical and dental information among people of Mexican origin. A sample of adults self-identified as European American (250) and as Mexican American (255), residing in Central Indiana, answered a one-time survey that included technology use questions and measured acculturation via the Psychological-Behavioral Acculturation Scale. Overall use of information technologies was estimated through an Information and Communication Technology score...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/29218011/pharmacogenetic-variation-in-over-100-genes-in-patients-receiving-acenocumarol
#7
Vanessa Gonzalez-Covarrubias, Javier Urena-Carrion, Beatriz Villegas-Torres, J Eduardo Cossío-Aranda, Sergio Trevethan-Cravioto, Raul Izaguirre-Avila, O Javier Fiscal-López, Xavier Soberon
Coumarins are widely prescribed worldwide, and in Mexico acenocumarol is the preferred form. It is well known that despite its efficacy, coumarins show a high variability for dose requirements. We investigated the pharmacogenetic variation of 110 genes in patients receiving acenocumarol using a targeted NGS approach. We report relevant population differentiation for variants on CYP2C8, CYP2C19, CYP4F11, CYP4F2, PROS, and GGCX, VKORC1, CYP2C18, NQO1. A higher proportion of novel-to-known variants for 10 genes was identified on 41 core pharmacogenomics genes related to the PK (29), PD (3), of coumarins, and coagulation proteins (9) including, CYP1A1, CYP3A4, CYP3A5, and F8, and a low proportion of novel-to-known variants on CYP2E1, VKORC1, and SULT1A1/2...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29216704/-prevalence-of-x-ray-signs-of-femoroacetabular-impingement-in-mexican-population
#8
R Gutiérrez-Ramos, S A Ávalos-Calderón, L A Bahena-Peniche
BACKGROUND: Femoroacetabular impingement (FAI) is a suggested diagnosis for pain in the hip in the absence of other apparent causes. It is thought to be a cause of progressive arthrosis of the hip. Our objective was to determine the prevalence of radiographic data of FAI in the adult population without hip pathology over a period of six months. MATERIAL AND METHODS: Analytical, observational, multicentric, ambispective and transverse study based on digital X-rays analysis...
May 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/29215914/feasibility-and-effectiveness-of-a-parenting-programme-for-mexican-parents-of-children-with-acquired-brain-injury-case-report
#9
Clara Chavez-Arana, Cathy Catroppa, Guillermina Yáñez Téllez, Celia Godfrey, Belén Prieto-Corona, Miguel A de León, Antonio García, Vicki Anderson
BACKGROUND: Acquired brain injury (ABI) during childhood typically causes behaviour problems in the child and high levels of stress in the family. OBJECTIVES: (1) To investigate the feasibility and effectiveness of a parenting programme to: improve behaviour and self-regulation (SR) in Mexican children with ABI, enhance parenting skills, and decrease parental stress in parents of children with ABI; (2) to explore the impact of parent SR on child. METHODS: Case study design with four participants post-ABI, aged 7-12 years, recruited in Mexico City...
December 7, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29214820/weight-management-behaviors-among-mexican-american-youth-cross-sectional-variation-by-timing-of-growth-and-maturation
#10
Jennifer L Gay, Eva V Monsma, Katie Darby Hein
PURPOSE: To assess the association between growth and maturation with weight management behaviors (WMBs) among Mexican American youth. DESIGN: A cross-sectional design was used to measure timing of growth and maturation as well as WMBs. SAMPLE: Students were recruited through physical education classes in south Texas schools. The sample included 623 participants (52.3% female; 49.8% with weight ≥85th percentile) in grades 4 through 12. Students in middle school were purposely oversampled to examine questions around timing of growth and maturation...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29214008/comparing-growth-in-surface-and-cave-morphs-of-the-species-astyanax-mexicanus-insights-from-scales
#11
Victor Simon, Romain Elleboode, Kélig Mahé, Laurent Legendre, Patricia Ornelas-Garcia, Luis Espinasa, Sylvie Rétaux
Background: Life in the darkness of caves is accompanied, throughout phyla, by striking phenotypic changes including the loss or severe reduction in eyes and pigmentation. On the other hand, cave animals have undergone constructive changes, thought to be adaptive, to survive in this extreme environment. The present study addresses the question of the evolution of growth in caves, taking advantage of the comparison between the river-dwelling and the cave-dwelling morphs of the Mexican tetra, Astyanax mexicanus...
2017: EvoDevo
https://www.readbyqxmd.com/read/29213152/serological-and-molecular-analysis-of-parvovirus-b19-infection-in-mayan-women-with-systemic-lupus-erythematosus-in-mexico
#12
Guillermo Valencia Pacheco, Yumi E Nakazawa Ueji, Edwin A Rodríguez Dzul, Angélica V Angulo Ramírez, Ricardo F López Villanueva, Irma G Quintal Ortiz, Elsy P Rosado Paredes
Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that mainly affects women, characterized by the production of autoantibodies. Its causal agent is unknown, but the combination of environmental, hormonal and genetic factors may favor the development of the disease. Parvovirus B19 has been associated with the development of SLE, since it induces the production of anti-single stranded DNA antibodies. It is unknown whether PV-B19 infection is an environmental factor that trigger or reactivate SLE in the Mexican Mayan population...
September 30, 2017: Colombia Médica: CM
https://www.readbyqxmd.com/read/29213072/characterization-of-large-copy-number-variation-in-mexican-type-2-diabetes-subjects
#13
Iván de Jesús Ascencio-Montiel, Dalila Pinto, Esteban J Parra, Adán Valladares-Salgado, Miguel Cruz, Stephen W Scherer
The effect of Copy Number Variants (CNVs) on Type 2 Diabetes (T2D) remains little explored. The present study characterized large rare CNVs in 686 T2D and 194 non-T2D subjects of Mexican ancestry genotyped using the Affymetrix Genome-Wide Human SNP array 5.0. Rare CNVs with ≥ 100 kb length were identified using a stringent strategy based on merging CNVs calls generated using Birdsuit, iPattern and PennCNV algorithms. We applied three different strategies to evaluate the distribution of CNVs in the T2D and non-T2D samples: 1) Burden analysis, 2) Identification of CNVs in loci previously associated to T2D, and 3) Identification of CNVs observed only in the T2D group...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29211259/prevalence-of-functioning-difficulties-and-disability-in-mexican-adolescent-women-and-their-populational-characteristics
#14
Betania Allen-Leigh, Celia Hubert, Filipa de Castro, Aremis Villalobos, Rosalba Rojas, Martín Romero, Tonatiuh Barrientos-Gutiérrez, Gregorio Katz, Eduardo Lazcano-Ponce
OBJECTIVE: Report prevalence of functioning difficulties and disabilities among Mexican adolescent women 15-17 years old and identify differences in characteristics of those with and without a functioning difficulty or disability. MATERIALS AND METHODS: Using data from the National Survey of Boys, Girls and Women in Mexico 2015 we estimated prevalence of functioning difficulties and disability and used chi square tests for independence and logistic regression to explore associations between this condition and various characteristics...
July 2017: Salud Pública de México
https://www.readbyqxmd.com/read/29211258/child-labor-and-severe-functioning-difficulties-and-disability-in-mexican-children-and-adolescents-5-17-years-of-age
#15
Aremis Villalobos, Filipa de Castro, Rosalba Rojas, Betania Allen-Leigh, Celia Hubert, Diana Avendaño-Badillo, Martín Romero, Agustín Vázquez-García, Tonatiuh Barrientos-Gutiérrez, Eduardo Lazcano-Ponce
OBJECTIVE: To describe the characteristics of Mexican children and adolescents 5-17 years with severe functioning difficulties and disability and explore their participation in child labor. MATERIALS AND METHODS: Using data from the National Survey of Boys, Girls and Women in Mexico 2015 we estimated prevalence of functioning difficulties and disability and used logistic regression to explore the association between this condition and child labor. RESULTS: While 11...
July 2017: Salud Pública de México
https://www.readbyqxmd.com/read/29211256/population-profiles-associated-with-severe-functioning-difficulties-and-disability-among-two-to-four-years-old-children-in-mexico
#16
Rosalba Rojas-Martínez, Filipa de Castro, Aremis Villalobos, Martín Romero, Betania Allen, Celia Hubert, Tonatiuh Barrientos-Gutiérrez, Eduardo Lazcano-Ponce
OBJECTIVE: To describe the prevalence and factors associated with severe child functioning difficulties and disability (CFD) among two to four year old children in Mexico, and estimates the probability of presenting CFD based on specific population profiles. MATERIALS AND METHODS: The sample consists of 5 104 children who participated in the National Survey of Children and Women 2015 (ENIM). We used post-estimation exploration by computing predicted values of CFD to interpret the logistic models for discrete combinations of the independent variables...
July 2017: Salud Pública de México
https://www.readbyqxmd.com/read/29206830/-the-masters-of-thoracic-trauma-in-the-central-hospital-of-the-mexican-red-cross-their-story-and-legacy
#17
Juan Carlos Vázquez-Minero, Guillermo Vallejo-Sandoval, Anette Ochmann-Ratch, Laura Portillo-Téllez, Demian Trueba-Lozano
The branches of medicine responsible for the care of victims of different types of injuries were born as a result of the urgent need to save lives during the wars. In Mexico, one of the first hospitals developed for the care of injured patients was the Central Hospital of the Mexican Red Cross. The aim of this article is to pay tribute to the first service for the care of patients with chest trauma, founded in 1954, its founders and those who have continued with their work: Dr. Pedro Garza Alegría, Dr. Octavio Rivas Solís Dr...
November 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29206825/clinical-competence-of-guatemalan-and-mexican-physicians-for-family-dysfunction-management
#18
Carlos Enrique Cabrera-Pivaral, María de Jesús Orozco-Valerio, Alfredo Celis-de la Rosa, María de Los Ángeles Covarrubias-Bermúdez, Marco Antonio Zavala-González
OBJECTIVE: To evaluate the clinical competence of Mexican and Guatemalan physicians to management the family dysfunction. METHODS: Cross comparative study in four care units first in Guadalajara, Mexico, and four in Guatemala, Guatemala, based on a purposeful sampling, involving 117 and 100 physicians, respectively. Clinical competence evaluated by validated instrument integrated for 187 items. Non-parametric descriptive and inferential statistical analysis was performed...
November 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29206821/-analysis-of-road-traffic-injuries-in-mexican-cyclists
#19
Victoria Alejandra Muro-Báez, M Eulalia Mendoza-García, Juan Daniel Vera-López, Ricardo Pérez-Núñez
With the objective of analyzing fatal and non-fatal road traffic injuries in cyclists and to document helmet use in this road user to inform sustainable mobility policies, a descriptive analysis of four secondary official information sources was conducted at the national level: mortality, Ministry of Health's hospital discharges, Unintentional and Violence Registry System (SIS-SS-17-P) and the 2012 National Health and Nutrition Survey (ENSANUT). Only SIS-SS-17-P and ENSANUT document helmet use. Except for ENSANUT information analyzed is of 2014...
November 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29203357/the-health-correlates-of-culture-examining-the-association-between-ethnic-racial-identity-and-diurnal-cortisol-slopes
#20
Katharine H Zeiders, José M Causadias, Rebecca M B White
PURPOSE: The objective of this study was to examine the link between ethnic-racial identity (ERI) components (exploration, resolution, and affirmation) and youths' diurnal cortisol slopes. METHODS: A sample of 103 U.S.-Mexican adolescents (Mage = 15.29 years) living in the Southwest participated in an in-home interview and 3-day salivary sampling protocol. RESULTS: ERI affirmation, but not exploration or resolution, was related to steeper diurnal slopes (greater declines in cortisol from waking to bedtime) after controlling for adolescents' life stressors, acculturation level, ethnic-racial discrimination, and daily behaviors (i...
December 1, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
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