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https://www.readbyqxmd.com/read/28822091/effect-of-ap102-a-subtype-2-and-5-specific-somatostatin-analog-on-glucose-metabolism-in-rats
#1
Erika Tarasco, Petra Seebeck, Svende Pfundstein, Adrian F Daly, Philippe J Eugster, Alan G Harris, Eric Grouzmann, Thomas A Lutz, Christina N Boyle
PURPOSE: Somatostatin analogs are widely used to treat conditions associated with hormonal hypersecretion such as acromegaly and metastatic neuroendocrine tumors. First generation somatostatin analogs, such as octreotide and lanreotide, have high affinity for somatostatin receptor subtype 2 (SSTR2), but have incomplete efficacy in many patients. Pasireotide targets multiple SSTRs, having the highest affinity for SSTR5, but causes hyperglycemia and diabetes mellitus in preclinical and clinical studies...
August 18, 2017: Endocrine
https://www.readbyqxmd.com/read/28820515/the-role-of-oncology-nurses-in-discussing-clinical-trials
#2
Susan A Flocke, Elizabeth Antognoli, Barbara J Daly, Brigid Jackson, Sarah E Fulton, Tasnuva M Liu, Jessica Surdam, Sharon Manne, Neal J Meropol
PURPOSE/OBJECTIVES: To describe oncology nurses' experiences discussing clinical trials with their patients, and to assess barriers to these discussions.
. RESEARCH APPROACH: A qualitative study designed to elicit narratives from oncology nurses. 
. SETTING: Community- and academic-based oncology clinics throughout the United States.
. PARTICIPANTS: 33 oncology nurses involved in direct patient care in community-based and large hospital-based settings...
September 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28818961/an-analogy-between-socioeconomic-deprivation-level-and-loss-of-health-from-adverse-effects-of-medical-treatment-in-england
#3
Raimundas Lunevicius, Juanita A Haagsma
BACKGROUND: The purpose of this study was to show whether and how levels, trends and patterns obtained from estimates of premature deaths from adverse effects (AEs) of medical treatment depended on the deprivation level in England over the 24-year period, 1990-2013. We provide a report to inform decision-making strategies to reduce the burden of disease arising from AEs of medical treatment in the most deprived areas of the country. METHODS: Comparative analysis was driven by a single cause-of-injury category-AEs of medical treatment-from the Global Burden of Disease 2013 study...
August 17, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28816437/selective-targeting-by-a-mechanism-based-inactivator-against-plp-dependent-enzymes-mechanisms-of-inactivation-and-alternative-turnover
#4
Romila Mascarenhas, Hoang V Le, Kenneth D Clevenger, Helaina J Lehrer, Dagmar Ringe, Neil L Kelleher, Richard B Silverman, Dali Liu
Potent mechanism-based inactivators can be rationally designed against PLP-dependent drug targets, such as ornithine aminotransferase (OAT) or γ-aminobutyric acid aminotransferase (GABA-AT). An important challenge, however, is the lack of selectivity towards other PLP-dependent off-target enzymes, because of similarities in mechanisms of all PLP-dependent aminotransferase reactions. On the basis of complex crystal structures, we investigate the inactivation mechanism of OAT, a hepatocellular carcinoma (HCC) target, by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid (FCP), a known inactivator of GABA-AT...
August 17, 2017: Biochemistry
https://www.readbyqxmd.com/read/28816428/aqueous-exfoliation-of-graphite-into-graphene-assisted-by-sulfonyl-graphene-quantum-dots-for-photonic-crystal-applications
#5
Minxiang Zeng, Smit A Shah, Dali Huang, Dorsa Parviz, Yi-Hsien Yu, Xuezhen Wang, Micah J Green, Zhengdong Cheng
We investigate the π-π stacking of polyaromatic hydrocarbons (PAHs) with graphene surfaces, showing that such interactions are general across a wide range of PAH sizes and species, including graphene quantum dots. We synthesized a series of graphene quantum dots with sulfonyl, amino and carboxylic functional groups and employed them to exfoliate and disperse pristine graphene in water. We observed that sulfonyl-functionalized graphene quantum dots were able to stabilize the highest concentration of graphene in comparison to other functional groups; this is consistent with prior findings by pyrene...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28816157/prophylactic-cranial-irradiation-for-small-cell-lung-cancer-new-insights
#6
Megan E Daly, David A Palma
No abstract text is available yet for this article.
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28811552/deregulation-of-transcription-factors-controlling-intestinal-epithelial-cell-differentiation-a-predisposing-factor-for-reduced-enteroendocrine-cell-number-in-morbidly-obese-individuals
#7
Bettina K Wölnerhanssen, Andrew W Moran, Galina Burdyga, Anne Christin Meyer-Gerspach, Ralph Peterli, Michael Manz, Miriam Thumshirn, Kristian Daly, Christoph Beglinger, Soraya P Shirazi-Beechey
Morbidly obese patients exhibit impaired secretion of gut hormones that may contribute to the development of obesity. After bariatric surgery there is a dramatic increase in gut hormone release. In this study, gastric and duodenal tissues were endoscopically collected from lean, and morbidly obese subjects before and 3 months after laparoscopic sleeve gastrectomy (LSG). Tissue morphology, abundance of chromogranin A, gut hormones, α-defensin, mucin 2, Na(+)/glucose co-transporter 1 (SGLT1) and transcription factors, Hes1, HATH1, NeuroD1, and Ngn3, were determined...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811365/a-model-explaining-the-matrilateral-bias-in-alloparental-investment
#8
Gretchen Perry, Martin Daly
Maternal grandmothers invest more in childcare than paternal grandmothers. This bias is large where the expression of preferences is unconstrained by residential and lineage norms, and is detectable even where marriage removes women from their natal families. We maintain that the standard evolutionary explanation, paternity uncertainty, is incomplete, and present an expanded model incorporating effects of alloparents on the mother as well as on her children. Alloparenting lightens a mother's load and increases her residual nepotistic value: her expected fitness from later investments in personal reproduction and in her natal relatives...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28810794/communication-stiff-and-soft-nano-environments-and-the-octopus-effect-are-the-crux-of-ionic-liquid-structural-and-dynamical-heterogeneity
#9
Ryan P Daly, Juan C Araque, Claudio J Margulis
In a recent set of articles [J. C. Araque et al., J. Phys. Chem. B 119(23), 7015-7029 (2015) and J. C. Araque et al., J. Chem. Phys. 144, 204504 (2016)], we proposed the idea that for small neutral and charged solutes dissolved in ionic liquids, deviation from simple hydrodynamic predictions in translational and rotational dynamics can be explained in terms of diffusion through nano-environments that are stiff (high electrostriction, charge density, and number density) and others that are soft (charge depleted)...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28809380/production-of-bone-mineral-material-and-bmp-2-in-osteoblasts-cultured-on-double-acid-etched-titanium
#10
R Velázquez-Cayón, G Castillo-Dalí, J-R Corcuera-Flores, M-A Serrera-Figallo, R Castillo-Oyagüe, M González-Martín, J-C Gutierrez-Pérez, D Torres-Lagares
BACKGROUND: The study of osteoblasts and their osteogenic functions is essential in order to understand them and their applications in implantology. In this sense, this study try to study BMP-2 production and bone matrix deposition, in addition to other biological variables, in osteoblasts cultured on a rough double acid-etched titanium surface (Osseotite®, Biomet 3i, Palm Beach Garden, Florida, USA) in comparison to a smooth titanium surface (machined) and a control Petri dish. MATERIALS AND METHODS: An in vitro prospective study...
August 15, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/28808642/burden-of-disease-attributable-to-vitamin-a-deficiency-in-iranian-population-aged-less-than-five-years-findings-from-the-global-burden-of-disease-study-2010
#11
Maryam Bahreynian, Mostafa Qorbani, Shohreh Naderimagham, Sara Nejatinamini, Asal Ataie-Jafari, Farshad Sharifi, Fahad Saqib, Alireza Khajavi, Morteza Mansourian, Ali Asghar Ahmadishokouh, Hamid Asayesh, Omid Safari, Roya Kelishadi
BACKGROUND: Vitamin A deficiency (VAD) is considered as one of the most serious public health concerns in developing countriesand the leading cause of mortality in under-five-year-old children.A large number of young children and pregnant women especially in low-income, non-industrialized communities are more susceptible to VAD. This study aims to report the burden of disease (BOD) attributable to VAD in Iranian population aged less than 5 years by using data of the Global Burden of Disease (GBD) study 2010...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28806992/comparison-of-an-alternative-schedule-of-extended-care-contacts-to-a-self-directed-control-a-randomized-trial-of-weight-loss-maintenance
#12
Gareth R Dutton, Marissa A Gowey, Fei Tan, Dali Zhou, Jamy Ard, Michael G Perri, Cora E Lewis
BACKGROUND: Behavioral interventions for obesity produce clinically meaningful weight loss, but weight regain following treatment is common. Extended care programs attenuate weight regain and improve weight loss maintenance. However, less is known about the most effective ways to deliver extended care, including contact schedules. METHODS: We compared the 12-month weight regain of an extended care program utilizing a non-conventional, clustered campaign treatment schedule and a self-directed program among individuals who previously achieved ≥5% weight reductions...
August 15, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28806146/three-dimensional-bioprinting-of-polycaprolactone-reinforced-gene-activated-bioinks-for-bone-tissue-engineering
#13
Gráinne M Cunniffe, Tomas Gonzalez-Fernandez, Andrew Daly, Binulal N Sathy, Oju Jeon, Eben Alsberg, Daniel J Kelly
Regeneration of complex bone defects remains a significant clinical challenge. Multi-tool biofabrication has permitted the combination of various biomaterials to create multifaceted composites with tailorable mechanical properties and spatially controlled biological function. In this study we sought to use bioprinting to engineer nonviral gene activated constructs reinforced by polymeric micro-filaments. A gene activated bioink was developed using RGD-γ-irradiated alginate and nano-hydroxyapatite (nHA) complexed to plasmid DNA (pDNA)...
August 14, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28804984/3d-bioprinting-for-cartilage-and-osteochondral-tissue-engineering
#14
REVIEW
Andrew C Daly, Fiona E Freeman, Tomas Gonzalez-Fernandez, Susan E Critchley, Jessica Nulty, Daniel J Kelly
Significant progress has been made in the field of cartilage and bone tissue engineering over the last two decades. As a result, there is real promise that strategies to regenerate rather than replace damaged or diseased bones and joints will one day reach the clinic however, a number of major challenges must still be addressed before this becomes a reality. These include vascularization in the context of large bone defect repair, engineering complex gradients for bone-soft tissue interface regeneration and recapitulating the stratified zonal architecture present in many adult tissues such as articular cartilage...
August 14, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28801234/dendritic-cells-but-not-macrophages-sense-tumor-mitochondrial-dna-for-cross-priming-through-signal-regulatory-protein-%C3%AE-signaling
#15
Meng Michelle Xu, Yang Pu, Dali Han, Yaoyao Shi, Xuezhi Cao, Hua Liang, Xiang Chen, Xiao-Dong Li, Liufu Deng, Zhijian J Chen, Ralph R Weichselbaum, Yang-Xin Fu
Inhibition of cytosolic DNA sensing represents a strategy that tumor cells use for immune evasion, but the underlying mechanisms are unclear. Here we have shown that CD47-signal regulatory protein α (SIRPα) axis dictates the fate of ingested DNA in DCs for immune evasion. Although macrophages were more potent in uptaking tumor DNA, increase of DNA sensing by blocking the interaction of SIRPα with CD47 preferentially occurred in dendritic cells (DCs) but not in macrophages. Mechanistically, CD47 blockade enabled the activation of NADPH oxidase NOX2 in DCs, which in turn inhibited phagosomal acidification and reduced the degradation of tumor mitochondrial DNA (mtDNA) in DCs...
August 15, 2017: Immunity
https://www.readbyqxmd.com/read/28799179/what-are-the-dietary-treatment-research-priorities-for-inflammatory-bowel-disease-a-short-report-based-on-a-priority-setting-partnership-with-the-james-lind-alliance
#16
M C Lomer, A L Hart, A Verjee, A Daly, J Solomon, J Mclaughlin
BACKGROUND: Treatment of inflammatory bowel disease (IBD) involves a multidisciplinary approach comprising medical management and sometimes surgery. Although diet is central to IBD management, the optimal diet for patients with IBD is uncertain. A UK collaborative partnership within the James Lind Alliance was set up between patients, clinicians and other stakeholders to develop research priorities in IBD. The aim of this short report is to provide a comprehensive summary of the research priority findings relating to diet in the treatment of IBD...
August 10, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28798163/draft-genome-sequences-of-multiple-frackibacter-strains-isolated-from-hydraulically-fractured-shale-environments
#17
Anne E Booker, Michael D Johnston, Rebecca A Daly, Kelly C Wrighton, Michael J Wilkins
The genomes of three novel Frackibacter strains (WG11, WG12, and WG13) were sequenced. These strains were isolated from hypersaline fluid collected from a hydraulically fractured natural gas well. These genomes provide information on the mechanisms necessary for growth in these environments and offer insight into interactions with other community members.
August 10, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28797458/nab-paclitaxel-based-induction-chemotherapy-with-or-without-cetuximab-for-locally-advanced-head-and-neck-squamous-cell-carcinoma
#18
Douglas Adkins, Jessica Ley, Peter Oppelt, Tanya M Wildes, Hiram A Gay, Mackenzie Daly, Jason Rich, Randal C Paniello, Ryan Jackson, Patrik Pipkorn, Brian Nussenbaum, Kathryn Trinkaus, Wade Thorstad
OBJECTIVES: To explore the effect of incorporating cetuximab into induction chemotherapy in locally advanced head and neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: Retrospective comparative analysis of two consecutive prospective phase II trials was performed: trial 1 with nab-paclitaxel/cisplatin/5-FU and cetuximab (APF-C; n=30) and trial 2 with APF (n=30). Patients were scheduled to receive chemoradiation therapy (CRT) with cisplatin. T2-4 classification oropharynx (OP)/larynx/hypopharynx SCC were included...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28797115/ranking-93-health-interventions-for-low-and-middle-income-countries-by-cost-effectiveness
#19
Susan Horton, Hellen Gelband, Dean Jamison, Carol Levin, Rachel Nugent, David Watkins
BACKGROUND: Cost-effectiveness rankings of health interventions are useful inputs for national healthcare planning and budgeting. Previous comprehensive rankings for low- and middle- income countries were undertaken in 2005 and 2006, accompanying the development of strategies for the Millennium Development Goals. We update the rankings using studies published since 2000, as strategies are being considered for the Sustainable Development Goals. METHODS: Expert systematic searches of the literature were undertaken for a broad range of health interventions...
2017: PloS One
https://www.readbyqxmd.com/read/28792274/global-regional-and-national-prevalence-incidence-and-disability-adjusted-life-years-for-oral-conditions-for-195-countries-1990-2015-a-systematic-analysis-for-the-global-burden-of-diseases-injuries-and-risk-factors
#20
N J Kassebaum, A G C Smith, E Bernabé, T D Fleming, A E Reynolds, T Vos, C J L Murray, W Marcenes
The Global Burden of Disease 2015 study aims to use all available data of sufficient quality to generate reliable and valid prevalence, incidence, and disability-adjusted life year (DALY) estimates of oral conditions for the period of 1990 to 2015. Since death as a direct result of oral diseases is rare, DALY estimates were based on years lived with disability, which are estimated only on those persons with unmet need for dental care. We used our data to assess progress toward the Federation Dental International, World Health Organization, and International Association for Dental Research's oral health goals of reducing the level of oral diseases and minimizing their impact by 2020...
April 2017: Journal of Dental Research
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