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https://www.readbyqxmd.com/read/29677073/outcomes-after-cardiac-transplant-for-wild-type-transthyretin-amyloidosis
#1
Andrew N Rosenbaum, Omar F Abou Ezzeddine, Martha Grogan, Angela Dispenzieri, Sudhir Kushwaha, Alfredo Clavell, Richard C Daly, Brooks S Edwards
BACKGROUND: The true prevalence of heart failure (HF) due to wild type transthyretin amyloidosis (ATTRwt) is likely underestimated. There is a paucity of data with regard to the management of ATTRwt-related advanced HF and the natural history of extracardiac ATTRwt. METHODS: We conducted a retrospective cohort study of patients undergoing cardiac transplant (HTx) for ATTRwt at a single institution. Comprehensive clinical data, including baseline hemodynamic and echocardiographic characteristics, and posttransplant outcomes were obtained...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29676997/mining-tcga-database-for-genes-of-prognostic-value-in-glioblastoma-microenvironment
#2
Di Jia, Shenglan Li, Dali Li, Haipeng Xue, Dan Yang, Ying Liu
Glioblastoma (GBM) is one of the most deadly brain tumors. The convenient access to The Cancer Genome Atlas (TCGA) database allows for large-scale global gene expression profiling and database mining for potential correlation between genes and overall survival of a variety of malignancies including GBM. Previous reports have shown that tumor microenvironment cells and the extent of infiltrating immune and stromal cells in tumors contribute significantly to prognosis. Immune scores and stromal scores calculated based on the ESTIMATE algorithm could facilitate the quantification of the immune and stromal components in a tumor...
April 16, 2018: Aging
https://www.readbyqxmd.com/read/29676123/-data-fusion-and-multi-components-quantitative-analysis-for-identification-and-quality-evaluation-of-gentiana-rigescens-from-different-geographical-origins
#3
Qin-Qin Wang, Tao Shen, Zhi-Tian Zuo, Heng-Yu Huang, Yuan-Zhong Wang
The accumulation of secondary metabolites of traditional Chinese medicine (TCM) is closely related to its origins. The identification of origins and multi-components quantitative evaluation are of great significance to ensure the quality of medicinal materials. In this study, the identification of Gentiana rigescens from different geographical origins was conducted by data fusion of Fourier transform infrared (FTIR) spectroscopy and high performance liquid chromatography (HPLC) in combination of partial least squares discriminant analysis; meanwhile quantitative analysis of index components was conducted to provide an accurate and comprehensive identification and quality evaluation strategy for selecting the best production areas of G...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29670253/cryopreservation-of-fish-spermatogonial-cells-the-future-of-natural-history-collections
#4
Mary M Hagedorn, Jonathan P Daly, Virginia L Carter, Kathleen S Cole, Zeehan Jaafar, Claire V A Lager, Lynne R Parenti
As global biodiversity declines, the value of biological collections increases. Cryopreserved diploid spermatogonial cells meet two goals: to yield high-quality molecular sequence data; and to regenerate new individuals, hence potentially countering species extinction. Cryopreserved spermatogonial cells that allow for such mitigative measures are not currently in natural history museum collections because there are no standard protocols to collect them. Vertebrate specimens, especially fishes, are traditionally formalin-fixed and alcohol-preserved which makes them ideal for morphological studies and as museum vouchers, but inadequate for molecular sequence data...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669791/retrospective-evaluation-of-infants-aged-1-60-days-with-residual-csf-tested-using-the-filmarray%C3%A2-meningitis-encephalitis-me-panel
#5
Anne J Blaschke, Kristen M Holmberg, Judy A Daly, Amy L Leber, Jennifer Dien Bard, Ernest K Korgenski, Kevin M Bourzac, Kristen J Kanack
In pediatric practice it is common for infants under 2 months of age to undergo evaluation for sepsis when they are ill, often including lumbar puncture (LP) to assess for central nervous system (CNS) infection. The FilmArray® Meningitis/Encephalitis (ME) Panel is a newly approved test for rapid identification of CNS pathogens. Our objective was to study the epidemiology of CNS infection in young infants and the potential impact of rapid multiplex PCR on their care.A performance evaluation of the FilmArray ME Panel was conducted from 2/2014-9/2014 at 11 sites...
April 18, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29669587/comparison-of-methods-to-assess-onset-of-breast-development-in-the-legacy-girls-study-methodological-considerations-for-studies-of-breast-cancer
#6
Lauren C Houghton, Julia A Knight, Mary Jane De Souza, Mandy Goldberg, Melissa L White, Karen O'Toole, Wendy K Chung, Angela R Bradbury, Mary B Daly, Irene L Andrulis, Esther M John, Saundra S Buys, Mary Beth Terry
BACKGROUND: Younger age at onset of breast development, which has been declining in recent decades, is associated with increased breast cancer risk independent of age at menarche. Given the need to study the drivers of these trends, it is essential to validate methods to assess breast onset that can be used in large-scale studies when direct clinical assessment of breast onset is not feasible. METHODS: Breast development is usually measured by Tanner stages (TSs), assessed either by physical examination or by mother's report using a picture-based Sexual Maturation Scale (SMS)...
April 18, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29669320/camkii-potentiates-store-operated-ca2-entry-through-enhancing-stim1-aggregation-and-interaction-with-orai1
#7
Shu Li, Jingyi Xue, Zhipeng Sun, Tiantian Liu, Lane Zhang, Limin Wang, Hongjie You, Zheng Fan, Yuanyuan Zheng, Dali Luo
BACKGROUND/AIMS: Upon Ca2+ store depletion, stromal interaction molecule 1 (STIM1) oligomerizes, redistributes near plasmalemma to interact with Ca2+ selective channel-forming subunit (Orai1) and initiates store-operated Ca2+ entry (SOCE). Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a regulator of SOCE, but how CaMKII regulates SOCE remains obscure. METHODS: Using Fura2, confocal microscopy, co-immunoprecipitation, specific blocker and overexpression/knockdown approaches, we evaluated STIM1 aggregation and its interaction with Orai1, and SOCE upon Ca2+ store depletion in thapsigargin (TG) treated HEK293 and HeLa cells...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29669193/unique-barriers-to-well-being-for-pathology-residents-and-how-to-address-them
#8
Katherine D Daly, Anuja S Mehta
No abstract text is available yet for this article.
April 18, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29665530/the-burden-of-disease-attributable-to-ambient-pm2-5-bound-pahs-exposure-in-nagpur-india
#9
Tunde O Etchie, Saravanadevi Sivanesan, Ayotunde T Etchie, Gregory O Adewuyi, Kannan Krishnamurthi, K V George, Padma S Rao
Exposure to PM2.5 -bound polycyclic aromatic hydrocarbons (PAHs) can elicit several types of cancer and non-cancer effects. Previous studies reported substantial burdens of PAH-induced lung cancer, but the burdens of other cancer types and non-cancer effects remain unknown. Thus, we estimate the cancer and non-cancer burden of disease, in disability-adjusted life years (DALYs), attributable to ambient PM2.5 -bound PAHs exposure in Nagpur district, India, using risk-based approach. We measured thirteen PAHs in airborne PM2...
April 11, 2018: Chemosphere
https://www.readbyqxmd.com/read/29664972/the-impact-of-social-and-psychological-consequences-of-disease-on-judgments-of-disease-severity-an-experimental-study
#10
Nicholas B King, Sam Harper, Meredith Young, Sarah C Berry, Kristin Voigt
BACKGROUND: The Global Burden of Disease (GBD) project systematically assesses mortality, healthy life expectancy, and disability across 195 countries and territories, using the disability-adjusted life year (DALY). Disability weights in the DALY are based upon surveys that ask users to rate health states based on lay descriptions. We conducted an experimental study to examine whether the inclusion or removal of psychological, social, or familial implications from a health state description might affect individual judgments about disease severity, and thus relative disability weights...
2018: PloS One
https://www.readbyqxmd.com/read/29664835/phagocytosis-by-fibrocytes-as-a-mechanism-to-decrease-bacterial-burden-and-increase-survival-in-sepsis
#11
Dalis Collins, Christopher Fry, Bethany B Moore, Jean A Nemzek
Fibrocytes are unique cells with innate and adaptive immune functions, but these mechanisms have not been fully explored. The aim of this study was to explain the mechanism by which adoptive transfer of exogenous fibrocytes improved bacterial clearance and increased sepsis survival. Initial flow cytometry-based, in vitro assays demonstrated phagocytosis by fibrocytes and intracellular bacterial killing was confirmed by direct plating of cell lysates after exposure to live bacteria. Intravenous adoptive transfer of fibrocytes at the time of cecal ligation and puncture (CLP) or two hours after CLP in mice increased survivability...
April 16, 2018: Shock
https://www.readbyqxmd.com/read/29664415/model-based-optimal-multipolar-stimulation-without-a-priori-knowledge-of-nerve-structure-application-to-vagus-nerve-stimulation
#12
Melissa Dali, Olivier Rossel, David Andreu, Laure Laporte, Alfredo Hernandez, Jeremy Laforet, Eloi Marijon, Albert Hagège, Maureen Clerc, Christine Henry, David Guiraud
OBJECTIVE: Multipolar cuff electrode can selectively stimulate areas of peripheral nerves and therefore enable to control independent functions. However, the branching and fascicularization are known for a limited set of nerves and the specific organization remains subject-dependent. This paper presents a general modeling and optimization methods in the context of multipolar stimulation using a cuff electrode without a priori knowledge of the nerve structure. Vagus nerve stimulation experiments based on the optimization results were then investigated...
April 17, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29661779/report-from-the-swog-radiation-oncology-committee-research-objectives-workshop-2017
#13
Paul Okunieff, Katherine Casey-Sawicki, Natalie A Lockney, Bradford S Hoppe, Heiko Enderling, Chelsea C Pinnix, James W Welsh, Sunil Krishnan, Greg Yothers, J Martin Brown, Susan J Knox, Robert G Bristow, Paul T Spellman, Timur Mitin, Nima Nabavizadeh, Jerry Jaboin, H Charles Manning, Felix Y Feng, Susan M Galbraith, Abhishek A Solanki, Matthew M Harkenrider, Richard Tuli, Roy H Decker, Steven E Finkelstein, Charles C Hsu, Chul S Ha, Reshma Jagsi, Dean Shumway, Megan Daly, Tony J C Wang, Thomas J FitzGerald, Fran Laurie, David T Marshall, David Raben, Louis S Constine, Charles R Thomas, Lisa A Kachnic
Experimental Design: Results: Conclusions.
April 16, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29661498/the-intra-day-dynamics-of-affect-self-esteem-tiredness-and-suicidality-in-major-depression
#14
Eimear Crowe, Michael Daly, Liam Delaney, Susan Carroll, Kevin M Malone
Despite growing interest in the temporal dynamics of Major Depressive Disorder (MDD), we know little about the intra-day fluctuations of key symptom constructs. In a study of momentary experience, the Experience Sampling Method captured the within-day dynamics of negative affect, positive affect, self-esteem, passive suicidality, and tiredness across clinical MDD (N= 31) and healthy control groups (N= 33). Ten symptom measures were taken per day over 6 days (N= 2231 observations). Daily dynamics were modeled via intra-day time-trends, variability, and instability in symptoms...
February 21, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29660687/novel-in-situ-lamella-fabrication-technique-for-in-situ-tem
#15
Megan Canavan, Dermot Daly, Andreas Rummel, Eoin K McCarthy, Cathal McAuley, Valeria Nicolosi
In-situ transmission electron microscopy is rapidly emerging as the premier technique for characterising materials in a dynamic state on the atomic scale. The most important aspect of in-situ studies is specimen preparation. Specimens must be electron transparent and representative of the material in its operational state, amongst others. Here, a novel fabrication technique for the facile preparation of lamellae for in-situ transmission electron microscopy experimentation using focused ion beam milling is developed...
March 29, 2018: Ultramicroscopy
https://www.readbyqxmd.com/read/29651912/effects-of-diclofenac-on-the-pharmacokinetics-of-celastrol-in-rats-and-its-transport
#16
Zengfu Wang, Dali Chen, Zhongwei Wang
CONTEXT: Diclofenac and celastrol are always used together for the treatment of rheumatoid arthritis; the herb-drug interaction potential between diclofenac and celastrol is still unknown. OBJECTIVE: This study investigates the effects of diclofenac on the pharmacokinetics of celastrol in rats. MATERIALS AND METHODS: Twelve male Sprague-Dawley rats were divided into two groups and received celastrol (1 mg/kg) or both celastrol (1 mg/kg) and diclofenac (10 mg/kg) by oral gavage, and blood samples were collected via the oculi chorioideae vein and determined using the LC-MS method developed in this study...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29650553/enduring-epigenetic-landmarks-define-the-cancer-microenvironment
#17
Ruth Pidsley, Mitchell G Lawrence, Elena Zotenko, Birunthi Niranjan, Aaron Statham, Jenny Song, Roman M Chabanon, Wenjia Qu, Hong Wang, Michelle Richards, Shalima S Nair, Nicola J Armstrong, Hieu T Nim, Melissa Papargiris, Preetika Balanathan, Hugh French, Timothy Peters, Sam Norden, Andrew Ryan, John Pedersen, James Kench, Roger J Daly, Lisa G Horvath, Phillip Stricker, Mark Frydenberg, Renea A Taylor, Clare Stirzaker, Gail P Risbridger, Susan J Clark
The growth and progression of solid tumors involves dynamic cross-talk between cancer epithelium and the surrounding microenvironment. To date, molecular profiling has largely been restricted to the epithelial component of tumors; therefore, features underpinning the persistent protumorigenic phenotype of the tumor microenvironment are unknown. Using whole-genome bisulfite sequencing, we show for the first time that cancer-associated fibroblasts (CAFs) from localized prostate cancer display remarkably distinct and enduring genome-wide changes in DNA methylation, significantly at enhancers and promoters, compared to nonmalignant prostate fibroblasts (NPFs)...
April 12, 2018: Genome Research
https://www.readbyqxmd.com/read/29649399/a-rules-based-algorithm-to-prioritize-poor-prognosis-cancer-patients-in-need-of-advance-care-planning
#18
Christine M Bestvina, Kristen E Wroblewski, Bobby Daly, Brittany Beach, Selina Chow, Andrew Hantel, Monica Malec, Michael T Huber, Blase N Polite
BACKGROUND: Accurate understanding of the prognosis of an advanced cancer patient can lead to decreased aggressive care at the end of life and earlier hospice enrollment. OBJECTIVE: Our goal was to determine the association between high-risk clinical events identified by a simple, rules-based algorithm and decreased overall survival, to target poor prognosis cancer patients who would urgently benefit from advanced care planning. DESIGN: A retrospective analysis was performed on outpatient oncology patients with an index visit from April 1, 2015, through June 30, 2015...
March 13, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29649153/health-impacts-of-ambient-air-pollution-in-finland
#19
Heli Lehtomäki, Antti Korhonen, Arja Asikainen, Niko Karvosenoja, Kaarle Kupiainen, Ville-Veikko Paunu, Mikko Savolahti, Mikhail Sofiev, Yuliia Palamarchuk, Ari Karppinen, Jaakko Kukkonen, Otto Hänninen
Air pollution has been estimated to be one of the leading environmental health risks in Finland. National health impact estimates existing to date have focused on particles (PM) and ozone (O₃). In this work, we quantify the impacts of particles, ozone, and nitrogen dioxide (NO₂) in 2015, and analyze the related uncertainties. The exposures were estimated with a high spatial resolution chemical transport model, and adjusted to observed concentrations. We calculated the health impacts according to Word Health Organization (WHO) working group recommendations...
April 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29642858/vaginal-birth-after-caesarean-versus-elective-repeat-caesarean-delivery-after-one-previous-caesarean-section-a-cost-effectiveness-analysis-in-four-european-countries
#20
Maaike Fobelets, Katrien Beeckman, Gilles Faron, Déirdre Daly, Cecily Begley, Koen Putman
BACKGROUND: The OptiBIRTH study incorporates a multicentre cluster randomised trial in 15 hospital sites across three European countries. The trial was designed to test a complex intervention aimed at improving vaginal birth after caesarean section (VBAC) rates through increasing women's involvement in their care. Prior to developing a robust standardised model to conduct the health economic analysis, an analysis of a hypothetical cohort was performed to estimate the costs and health effects of VBAC compared to elective repeat caesarean delivery (ERCD) for low-risk women in four European countries...
April 11, 2018: BMC Pregnancy and Childbirth
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