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https://www.readbyqxmd.com/read/28441624/various-soil-amendments-and-environmental-wastes-affect-the-im-mobilization-and-phytoavailability-of-potentially-toxic-elements-in-a-sewage-effluent-irrigated-sandy-soil
#1
Sabry M Shaheen, Mohamed S Shams, Mohamed R Khalifa, Mohamed A El-Dali, Jörg Rinklebe
Contamination of long-term sewage effluent irrigated soils by potentially toxic elements (PTEs) is a serious concern due to its high environmental and health risk. Our scientific hypothesis is that soil amendments can cause contradictory effects on the element mobilization and phytoavailability depending on the type of element and amendment. Therefore, we aimed to assess the impact of the application (1%) of several low cost amendments and environmental wastes on the (im)mobilization, availability, and uptake of Al, Cd, Cr, Cu, Fe, Mn, Ni, and Zn by sorghum (Sorghum bicolor) in a long term sewage effluent irrigated sandy soils collected from Egypt...
April 22, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28441053/evaluation-of-oxygen-administration-with-a-high-flow-nasal-cannula-to-clinically-normal-dogs
#2
Jennifer L Daly, Christine L Guenther, Jamie M Haggerty, Iain Keir
OBJECTIVE To evaluate the safety and efficacy of oxygen administration by use of a high-flow nasal cannula (HFNC) in sedated clinically normal dogs. ANIMALS 6 healthy adult dogs undergoing routine dental prophylaxis. PROCEDURES Dogs were sedated with butorphanol tartrate and dexmedetomidine. An esophageal balloon catheter was inserted into the esophagus, a double-pronged nasal cannula was inserted into the nares, and a catheter was inserted into the dorsal pedal artery. Dogs were positioned in right lateral recumbency...
May 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28440022/mir-372-3p-promotes-cell-growth-and-metastasis-by-targeting-fgf9-in-lung-squamous-cell-carcinoma
#3
Qing Wang, Siyang Liu, Xitong Zhao, Yuan Wang, Dali Tian, Wenjun Jiang
The aim of this study was to study the role of miR-372-3p in lung squamous cell carcinoma (LSCC) cell proliferation and invasion by suppressing FGF9. RT-PCR was used to determine miR-372-3p and FGF9 mRNA expression in tissues and cells. Western blot was used to determine FGF9 expression in tissues and NCI-H520 cell line. Dual luciferase reporter gene assay was conducted to confirm that FGF9 can be directly targeted by miR-372-3p. MTT, colony formation assays were conducted to investigate the effects of ectopic miR-372-3p and FGF9 expression on NCI-H520 cell growth...
April 24, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28439101/largest-gwas-of-ptsd-n-20%C3%A2-070-yields-genetic-overlap-with-schizophrenia-and-sex-differences-in-heritability
#4
L E Duncan, A Ratanatharathorn, A E Aiello, L M Almli, A B Amstadter, A E Ashley-Koch, D G Baker, J C Beckham, L J Bierut, J Bisson, B Bradley, C-Y Chen, S Dalvie, L A Farrer, S Galea, M E Garrett, J E Gelernter, G Guffanti, M A Hauser, E O Johnson, R C Kessler, N A Kimbrel, A King, N Koen, H R Kranzler, M W Logue, A X Maihofer, A R Martin, M W Miller, R A Morey, N R Nugent, J P Rice, S Ripke, A L Roberts, N L Saccone, J W Smoller, D J Stein, M B Stein, J A Sumner, M Uddin, R J Ursano, D E Wildman, R Yehuda, H Zhao, M J Daly, I Liberzon, K J Ressler, C M Nievergelt, K C Koenen
The Psychiatric Genomics Consortium-Posttraumatic Stress Disorder group (PGC-PTSD) combined genome-wide case-control molecular genetic data across 11 multiethnic studies to quantify PTSD heritability, to examine potential shared genetic risk with schizophrenia, bipolar disorder, and major depressive disorder and to identify risk loci for PTSD. Examining 20 730 individuals, we report a molecular genetics-based heritability estimate (h(2)SNP) for European-American females of 29% that is similar to h(2)SNP for schizophrenia and is substantially higher than h(2)SNP in European-American males (estimate not distinguishable from zero)...
April 25, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28438911/human-infectious-disease-burdens-decrease-with-urbanization-but-not-with-biodiversity
#5
Chelsea L Wood, Alex McInturff, Hillary S Young, DoHyung Kim, Kevin D Lafferty
Infectious disease burdens vary from country to country and year to year due to ecological and economic drivers. Recently, Murray et al. (Murray CJ et al 2012 Lancet380, 2197-2223. (doi:10.1016/S0140-6736(12)61689-4)) estimated country-level morbidity and mortality associated with a variety of factors, including infectious diseases, for the years 1990 and 2010. Unlike other databases that report disease prevalence or count outbreaks per country, Murray et al. report health impacts in per-person disability-adjusted life years (DALYs), allowing comparison across diseases with lethal and sublethal health effects...
June 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28438507/cardiothoracic-transplant-recipient-mycoplasma-hominis-an-uncommon-infection-with-probable-donor-transmission
#6
Rahul Sampath, Robin Patel, Scott A Cunningham, Sana Arif, Richard C Daly, Andrew D Badley, Mark E Wylam
The role of infection with Mycoplasma hominis following cardiothoracic organ transplantation and its source of transmission have not been well-defined. Here, we identify and describe infection with M. hominis in patients following cardiothoracic organ transplantation after reviewing all cardiothoracic transplantations performed at our center between 1998 and July 2015. We found seven previously unreported cases of M. hominis culture positive infection all of whom presented with pleuritis, surgical site infection, and/or mediastinitis...
April 19, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28437891/the-therapeutic-effect-of-nano-encapsulated-and-nano-emulsion-forms-of-carvacrol-on-experimental-liver-fibrosis
#7
Jihan Hussein, Mona El-Banna, Khaled F Mahmoud, Safaa Morsy, Yasmin Abdel Latif, Dalia Medhat, Eman Refaat, Abdel Razik Farrag, Sherien M El-Daly
OBJECTIVE: The present study aimed to compare the therapeutic efficiency of nano-encapsulated and nano-emulsion carvacrol administration on liver injury in thioacetamide (TAA) treated rats. METHODS: To fulfill our target, we used sixty male albino rats classified into six groups as follow: control, nano-encapsulated carvacrol, nano-emulsion carvacrol, thioacetamide, treated nano-encapsulated carvacrol and treated nano-emulsion carvacrol groups. Blood samples were collected from all groups and the separated serum was used for analysis of the following biochemical parameters; aspartate aminotransferase (AST), alanine aminotransferase (ALT), S100 B protein, alpha fetoprotein (AFP) and caspase-3...
April 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28434660/reduced-dose-radiotherapy-for-human-papillomavirus-associated-squamous-cell-carcinoma-of-the-oropharynx-a-single-arm-phase-2-study
#8
Allen M Chen, Carol Felix, Pin-Chieh Wang, Sophia Hsu, Vincent Basehart, Jordan Garst, Phillip Beron, Deborah Wong, Michael H Rosove, Shyam Rao, Heather Melanson, Edward Kim, Daphne Palmer, Lihong Qi, Karen Kelly, Michael L Steinberg, Patrick A Kupelian, Megan E Daly
BACKGROUND: Head and neck cancers positive for human papillomavirus (HPV) are exquisitely radiosensitive. We investigated whether chemoradiotherapy with reduced-dose radiation would maintain survival outcomes while improving tolerability for patients with HPV-positive oropharyngeal carcinoma. METHODS: We did a single-arm, phase 2 trial at two academic hospitals in the USA, enrolling patients with newly diagnosed, biopsy-proven stage III or IV squamous-cell carcinoma of the oropharynx, positive for HPV by p16 testing, and with Zubrod performance status scores of 0 or 1...
April 20, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28432738/tick-bite-and-lyme-disease-related-emergency-department-encounters-in-new-hampshire-2010-2014
#9
E R Daly, C Fredette, A A Mathewson, K Dufault, D J Swenson, B P Chan
Lyme disease (LD) is a common tick-borne disease in New Hampshire (NH). While LD is a reportable condition and cases are counted for public health surveillance, many more people receive care for tick bites or diagnoses of LD than are reflected in surveillance data. NH's emergency department (ED) data system was queried for tick bite and LD-related encounters. Chief complaint text was queried for words related to LD or tick bites. International Classification of Diseases 9th Revision (ICD-9) codes were queried for the LD diagnosis code (088...
April 22, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28428794/fine-mapping-of-a-novel-defective-glume-1-dg1-mutant-which-affects-vegetative-and-spikelet-development-in-rice
#10
Haiping Yu, Banpu Ruan, Zhongwei Wang, Deyong Ren, Yu Zhang, Yujia Leng, Dali Zeng, Jiang Hu, Guangheng Zhang, Li Zhu, Zhenyu Gao, Guang Chen, Longbiao Guo, Wenfu Chen, Qian Qian
In cereal crops, vegetative and spikelet development play important roles in grain yield and quality, but the genetic mechanisms that control vegetative and spikelet development remain poorly understood in rice. Here, we identified a new rice mutant, defective glume 1 (dg1) mutant from cultivar Zhonghua11 after ethyl methanesulfonate treatment. The dg1 mutant displayed the dwarfism with small, rolled leaves, which resulted from smaller cells and more bulliform cells. The dg1 mutant also had an enlarged leaf angle and defects in brassinosteroid signaling...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28428185/investments-in-cancer-research-awarded-to-uk-institutions-and-the-global-burden-of-cancer-2000-2013-a-systematic-analysis
#11
Mahiben Maruthappu, Michael G Head, Charlie D Zhou, Barnabas J Gilbert, Majd A El-Harasis, Rosalind Raine, Joseph R Fitchett, Rifat Atun
OBJECTIVES: To systematically categorise cancer research investment awarded to United Kingdom (UK) institutions in the period 2000-2013 and to estimate research investment relative to disease burden as measured by mortality, disability-adjusted life years (DALYs) and years lived with disability (YLDs). DESIGN: Systematic analysis of all open-access data. SETTING AND PARTICIPANTS: Public and philanthropic funding to all UK cancer research institutions, 2000-2013...
April 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28428050/socioeconomic-disparity-in-global-burden-of-cataract-an-analysis-for-2013-with-time-trends-since-1990
#12
Lixia Lou, Jingyi Wang, Peifang Xu, Xin Ye, Juan Ye
PURPOSE: To assess socioeconomic disparity in global burden of cataract, by using disability-adjusted life years (DALYs). DESIGN: International, comparative burden-of-disease study. METHODS: Published data on national age-standardized DALY rates caused by cataract and human development index (HDI) between 1990 and 2013 were obtained. The association between age-standardized DALY rates and HDI in 2013 was analyzed. The health-related Gini coefficients and the concentration indexes were calculated to explore the trends in between-country inequality in cataract burden from 1990 to 2013...
April 17, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28425707/development-of-a-potent-wound-healing-agent-based-on-the-liver-fluke-granulin-structural-fold
#13
Paramjit S Bansal, Michael J Smout, David Wilson, Claudia Cobos Caceres, Mohadeseh Dastpeyman, Javier Sotillo, Julia Seifert, Paul J Brindley, Alex Loukas, Norelle L Daly
Granulins are a family of protein growth factors that are involved in cell proliferation. An orthologue of granulin from the human parasitic liver fluke Opisthorchis viverrini, known as Ov-GRN-1, induces angiogenesis and accelerates wound repair. Recombinant Ov-GRN-1 production is complex, and poses an obstacle for clinical development. To identify the bioactive region(s) of Ov-GRN-1, four truncated N-terminal analogues were synthesized and characterized structurally using NMR spectroscopy. Peptides that contained only two native disulfide bonds lack the characteristic granulin -hairpin structure...
April 20, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28424003/phenotypic-heterogeneity-in-a-congenital-disorder-of-glycosylation-caused-by-mutations-in-stt3a
#14
Arunabha Ghosh, Jill Urquhart, Sarah Daly, Anne Ferguson, Diana Scotcher, Andrew A M Morris, Jill Clayton-Smith
STT3A encodes the catalytic subunit of the oligosaccharyltransferase complex. A congenital disorder of glycosylation caused by mutations in STT3A has only been reported in one family to date, associated with a Type I congenital disorder of glycosylation pattern of transferrin glycoforms. The authors describe a further 5 related individuals with a likely pathogenic variant in STT3A, 2 of whom also had variants in TUSC3. Common phenotypic features in all symptomatic individuals include developmental delay, intellectual disability, with absent speech and seizures...
May 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28422308/androgen-receptor-regulated-mirna-193a-3p-targets-ajuba-to-promote-prostate-cancer-cell-migration
#15
Li Jia, Bin Gui, Dali Zheng, Keith F Decker, Ilker Tinay, Mingyue Tan, Xiaowei Wang, Adam S Kibel
Background Dysregulation of microRNA (miRNA) expression is implicated in cancer development and progression by modulating oncogenes or tumor suppressors at the post-transcriptional level. Methods To investigate the role of miRNAs in prostate cancer (PCa) progression, we performed small RNA-sequencing (RNA-seq) analysis in androgen-dependent LNCaP cells and LNCaP-derived castration-resistant prostate cancer (CRPC) C4-2B cells. For functional validation, we specifically investigated miR-193a-3p, which is highly upregulated in C4-2B cells and modulated by the androgen receptor (AR)...
April 19, 2017: Prostate
https://www.readbyqxmd.com/read/28421125/automatic-microaneurysms-detection-based-on-multifeature-fusion-dictionary-learning
#16
Wei Zhou, Chengdong Wu, Dali Chen, Zhenzhu Wang, Yugen Yi, Wenyou Du
Recently, microaneurysm (MA) detection has attracted a lot of attention in the medical image processing community. Since MAs can be seen as the earliest lesions in diabetic retinopathy, their detection plays a critical role in diabetic retinopathy diagnosis. In this paper, we propose a novel MA detection approach named multifeature fusion dictionary learning (MFFDL). The proposed method consists of four steps: preprocessing, candidate extraction, multifeature dictionary learning, and classification. The novelty of our proposed approach lies in incorporating the semantic relationships among multifeatures and dictionary learning into a unified framework for automatic detection of MAs...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28420339/protocol-for-the-development-of-a-salutogenic-intrapartum-core-outcome-set-sipcos
#17
Valerie Smith, Deirdre Daly, Ingela Lundgren, Tine Eri, Cecily Begley, Mechthild M Gross, Soo Downe, Zarko Alfirevic, Declan Devane
BACKGROUND: Maternity intrapartum care research and clinical care more often focus on outcomes that minimise or prevent adverse health rather than on what constitutes positive health and wellbeing (salutogenesis). This was highlighted recently in a systematic review of reviews of intrapartum reported outcomes where only 8% of 1648 individual outcomes, from 102 systematic reviews, were agreed as being salutogenically-focused. Added to this is variation in the outcomes measured in individual studies rendering it very difficult for researchers to synthesise, fully, the evidence from studies on a particular topic...
April 19, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28419715/a-survey-on-faculty-perspectives-on-the-transition-to-a-biochemistry-course-based-undergraduate-research-experience-laboratory
#18
Paul A Craig
It will always remain a goal of an undergraduate biochemistry laboratory course to engage students hands-on in a wide range of biochemistry laboratory experiences. In 2006, our research group initiated a project for in silico prediction of enzyme function based only on the 3D coordinates of the more than 3800 proteins "of unknown function" in the Protein Data Bank, many of which resulted from the Protein Structure Initiative. Students have used the ProMOL plugin to the PyMOL molecular graphics environment along with BLAST, Pfam, and Dali to predict protein functions...
April 16, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/28418452/multigene-panel-testing-and-breast-cancer-risk-is-it-time-to-scale-down
#19
Elias I Obeid, Michael J Hall, Mary B Daly
No abstract text is available yet for this article.
April 13, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28417995/corrigendum-do-primary-care-provider-strategies-improve-patient-participation-in-colorectal-cancer-screening
#20
Nancy N Baxter, Rinku Sutradhar, Qing Li, Corinne Daly, Gladys N Honein-AbouHaidar, Devon P Richardson, Lisa Del Giudice, Jill Tinmouth, Lawrence Paszat, Linda Rabeneck
No abstract text is available yet for this article.
April 18, 2017: American Journal of Gastroenterology
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