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https://www.readbyqxmd.com/read/29216670/-systematic-review-of-the-burden-of-campylobacter-associated-disease
#1
Julia Lackner, Daniela Schlichting, Christine Müller-Graf, Matthias Greiner
Bacteria of the genus Campylobacter spp. are one of the most common causes of gastroenteritis and can lead to serious sequelae. Several studies have estimated the disease burden of Campylobacter spp. with the quantitative metric of disability-adjusted life years (DALY). The aim of this systematic review is to give an overview of the information available about different countries and periods for which DALYs were calculated and how the different results are comparable. One of the most important transmission pathways for Campylobacter spp...
December 7, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29216565/incidence-prevalence-mortality-disability-adjusted-life-years-and-risk-factors-of-cancer-in-australia-and-comparison-with-oecd-countries-1990-2015-findings-from-the-global-burden-of-disease-study-2015
#2
Yohannes Adama Melaku, Sarah L Appleton, Tiffany K Gill, Felix A Ogbo, Elizabeth Buckley, Zumin Shi, Tim Driscoll, Robert Adams, Benjamin C Cowie, Christina Fitzmaurice
BACKGROUND: Comparative evidence on the burden, trend, and risk factors of cancer is limited. Using data from the Global Burden of Disease (GBD) study, we aimed to assess cancer burden - incidence, prevalence, mortality, disability-adjusted life years (DALYs) - and attributable risk factors for Australia between 1990 and 2015, and to compare them with those of 34 members of the Organisation for Economic Co-operation and Development (OECD). METHODS: The general GBD cancer estimation methods were used with data input from vital registration systems and cancer registries...
December 4, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29215367/interperforator-flow-pattern-and-clinical-application-of-distal-extended-peroneal-artery-perforator-flaps
#3
Chengliang Deng, Bihua Wu, Zairong Wei, Hai Li, Tianhua Zhang, Dali Wang
INTRODUCTION: Peroneal artery perforator flaps are the most widely used pedicled flaps for soft tissue defects of the distal lower extremity. Most research regarding peroneal artery flaps focuses on the location, diameter, and number of peroneal artery perforators. However, there is little literature regarding interperforator flow patterns within the peroneal artery perforator flaps. The aims of the present study were to describe interperforator flow patterns of the distally based extended peroneal artery perforator flaps through digital subtraction angiography and review their clinical application...
December 5, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29212509/incremental-cost-and-cost-effectiveness-of-low-dose-high-frequency-training-in-basic-emergency-obstetric-and-newborn-care-as-compared-to-status-quo-part-of-a-cluster-randomized-training-intervention-evaluation-in-ghana
#4
Michelle Willcox, Heather Harrison, Amos Asiedu, Allyson Nelson, Patricia Gomez, Amnesty LeFevre
BACKGROUND: Low-dose, high-frequency (LDHF) training is a new approach best practices to improve clinical knowledge, build and retain competency, and transfer skills into practice after training. LDHF training in Ghana is an opportunity to build health workforce capacity in critical areas of maternal and newborn health and translate improved capacity into better health outcomes. METHODS: This study examined the costs of an LDHF training approach for basic emergency obstetric and newborn care and calculates the incremental cost-effectiveness of the LDHF training program for health outcomes of newborn survival, compared to the status quo alternative of no training...
December 6, 2017: Globalization and Health
https://www.readbyqxmd.com/read/29210951/health-burden-and-socioeconomic-disparities-from-hearing-loss-a-global-perspective
#5
Tam Ramsey, Peter F Svider, Adam J Folbe
OBJECTIVES/HYPOTHESIS: To characterize the disability-related health burden of hearing loss (HL) at a global level, with a focus on socioeconomic health disparities. METHODS: The global burden of HL, as calculated by disability-adjusted life years (DALYs) per 100,000 individuals, was evaluated for 184 countries. Data from 5-year intervals encompassing 1990 to 2015 were organized by human development index (HDI) categorizations as specified by the U.N. Development Program (UNDP)...
November 28, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29210385/lighting-up-protein-ligand-interactions-with-fluorescent-pet-photoinduced-electron-transfer-sensor-designs
#6
Bernard McLaughlin, Esther M Surender, Glenn D Wright, Brian Daly, A Prasanna de Silva
The fluorescence of sensors 1 and 6, which are designed in terms of photoinduced electron transfer (PET), is switched 'on' by factors of 15 and 6 with avidin in a rather selective manner. Sensors 3 and 7, simpler derivatives of 1, are switched 'on' by factors of 16 and 7.5 with bovine serum albumin, though at 30-fold higher concentrations.
December 6, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29209039/author-correction-tyrosine-dephosphorylated-cortactin-downregulates-contractility-at-the-epithelial-zonula-adherens-through-srgap1
#7
Xuan Liang, Srikanth Budnar, Shafali Gupta, Suzie Verma, Siew-Ping Han, Michelle M Hill, Roger J Daly, Robert G Parton, Nicholas A Hamilton, Guillermo A Gomez, Alpha S Yap
A correction to this article has been published and is linked from the HTML version of this article.
December 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/29209002/the-orientation-and-stability-of-the-gpcr-arrestin-complex-in-a-lipid-bilayer
#8
Dali Wang, Hua Yu, Xiangdong Liu, Jianqiang Liu, Chen Song
G protein-coupled receptors (GPCRs) constitute a large family of membrane proteins that plays a key role in transmembrane signal transduction and draw wide attention since it was discovered. Arrestin is a small family of proteins which can bind to GPCRs, block G protein interactions and redirect signaling to G-protein-independent pathways. The detailed mechanism of how arrestin interacts with GPCR remains elusive. Here, we conducted molecular dynamics simulations with coarse-grained (CG) and all-atom (AA) models to study the complex structure formed by arrestin and rhodopsin, a prototypical GPCR, in a POPC bilayer...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29207201/hypoxia-modulates-the-stem-cell-population-and-induces-emt-in-the-mcf-10a-breast-epithelial-cell-line
#9
Carl S Daly, Arwa Flemban, Mai Shafei, Myra E Conway, David Qualtrough, Sarah J Dean
A common feature among pre-malignant lesions is the induction of hypoxia through increased cell propagation and reduced access to blood flow. Hypoxia in breast cancer has been associated with poor patient prognosis, resistance to chemotherapy and increased metastasis. Although hypoxia has been correlated with factors associated with the latter stages of cancer progression, it is not well documented how hypoxia influences cells in the earliest stages of transformation. Using the immortalized MCF-10A breast epithelial cell line, we used hypoxic culture conditions to mimic reduced O2 levels found within early pre-malignant lesions and assessed various cellular parameters...
December 1, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29207087/p-stat3-in-luminal-breast-cancer-integrated-rna-protein-pooled-analysis-and-results-from-the-big-2-98-phase-iii-trial
#10
Amir Sonnenblick, Roberto Salgado, Sylvain Brohée, Tamar Zahavi, Tamar Peretz, Gert Van den Eynden, Ghizlane Rouas, Asher Salmon, Prudence A Francis, Angelo Di Leo, John P A Crown, Giuseppe Viale, Laura Daly, Bahar Javdan, Sho Fujisawa, Evandro De Azambuja, Ameye Lieveke, Martine J Piccart, Jacqueline F Bromberg, Christos Sotiriou
In the present study, in order to investigate the role of signal transducer and activator of transcription 3 (STAT3) in estrogen receptor (ER)-positive breast cancer prognosis, we evaluated the phosphorylated STAT3 (p-STAT3) status and investigated its effect on the outcome in a pooled analysis and in a large prospective adjuvant trial. By using the TCGA repository, we developed gene signatures that reflected the level of p-STAT3. Using pooled analysis of the expression data from luminal breast cancer patients, we assessed the effects of the p-STAT3 expression signature on prognosis...
November 27, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29205676/now-more-than-ever
#11
Priscilla Robinson, Jeanne Daly
No abstract text is available yet for this article.
December 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29205463/mode-of-birth-and-postnatal-health-related-quality-of-life-after-one-previous-cesarean-in-three-european-countries
#12
Maaike Fobelets, Katrien Beeckman, Ronald Buyl, Déirdre Daly, Marlene Sinclair, Patricia Healy, Susanne Grylka-Baeschlin, Jane Nicoletti, Mechthild M Gross, Sandra Morano, Koen Putman
BACKGROUND: How a woman gives birth can affect her health-related quality of life (HRQoL). This study explored HRQoL at 3 months postpartum in women with a history of one previous cesarean in three European countries. METHODS: A prospective longitudinal survey, embedded within a cluster randomized trial in three countries, exploring women's postnatal HRQoL up to 3 months postpartum. The Short-Form Six-Dimensions (SF-6D) was used to measure HRQoL, and multivariate analyses were used to examine the relationship with mode of birth...
December 5, 2017: Birth
https://www.readbyqxmd.com/read/29202912/assessing-almond-and-peanut-allergens-using-commercially-available-immunoanalytical-kits-and-lc-ms-ms-a-case-study
#13
Matthew Daly, Parisa Ansari, Georg Häubl, Adrian Rogers, Kurt Brunner
With an ever-increasing allergic population and an emerging market for allergen-free foods, accurate detectionof allergens in foods has never been more important. Although ELISA-based methods are the most widely used for detection of allergens in food, there is a need for the development of orthogonal approaches. A commercial ELISA detected a relatively high concentration of peanut and almond in an allergen-free product. However, another commercial ELISA declared a low peanut concentration and was negative for almond...
December 5, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/29202828/calculation-of-the-disease-burden-associated-with-environmental-chemical-exposures-application-of-toxicological-information-in-health-economic-estimation
#14
REVIEW
Philippe Grandjean, Martine Bellanger
Calculation of costs and the Burden of Disease (BoD) is useful in developing resource allocation and prioritization strategies in public and environmental health. While useful, the Disability-Adjusted Life Year (DALY) metric disregards subclinical dysfunctions, adheres to stringent causal criteria, and is hampered by gaps in environmental exposure data, especially from industrializing countries. For these reasons, a recently calculated environmental BoD of 5.18% of the total DALYs is likely underestimated. We combined and extended cost calculations for exposures to environmental chemicals, including neurotoxicants, air pollution, and endocrine disrupting chemicals, where sufficient data were available to determine dose-dependent adverse effects...
December 5, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29202779/correlates-of-poor-mental-health-in-early-pregnancy-in-obese-european-women
#15
Matteo C Sattler, Judith G M Jelsma, Annick Bogaerts, David Simmons, Gernot Desoye, Rosa Corcoy, Juan M Adelantado, Alexandra Kautzky-Willer, Jürgen Harreiter, Frans A van Assche, Roland Devlieger, Goele Jans, Sander Galjaard, David Hill, Peter Damm, Elisabeth R Mathiesen, Ewa Wender-Ozegowska, Agnieszka Zawiejska, Kinga Blumska, Annunziata Lapolla, Maria G Dalfrà, Alessandra Bertolotto, Fidelma Dunne, Dorte M Jensen, Lise Lotte T Andersen, Frank J Snoek, Mireille N M van Poppel
BACKGROUND: Depression during pregnancy is associated with higher maternal morbidity and mortality, and subsequent possible adverse effects on the cognitive, emotional and behavioral development of the child. The aim of the study was to identify maternal characteristics associated with poor mental health, in a group of overweight/obese pregnant women in nine European countries, and thus, to contribute to better recognition and intervention for maternal depression. METHODS: In this cross-sectional observational study, baseline data from early pregnancy (< 20 weeks) of the DALI (Vitamin D and Lifestyle Intervention for gestational diabetes mellitus prevention) study were analyzed...
December 4, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29198624/stereotactic-body-radiation-therapy-versus-surgery-for-early-lung-cancer-among-us%C3%A2-veterans
#16
Alex K Bryant, Robert C Mundt, Ajay P Sandhu, James J Urbanic, Andrew B Sharabi, Samir Gupta, Megan E Daly, James D Murphy
BACKGROUND: Stereotactic body radiation therapy (SBRT) has been proposed as a potential alternative to surgery for early lung cancer, although we lack well-powered prospective randomized data comparing these treatments, and existing studies suffer from incomplete information on confounders that can bias results. Here, we evaluated the comparative effectiveness of surgery and SBRT in lung cancer treatment using a large extensively detailed database from the Veteran's Affairs system. METHODS: We identified veterans with biopsy-proven clinical stage I non-small cell lung cancer diagnosed between 2006 and 2015 from within the Veteran's Affairs Informatics and Computing Infrastructure...
November 21, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29195075/an-unexpectedly-complex-architecture-for-skin-pigmentation-in-africans
#17
Alicia R Martin, Meng Lin, Julie M Granka, Justin W Myrick, Xiaomin Liu, Alexandra Sockell, Elizabeth G Atkinson, Cedric J Werely, Marlo Möller, Manjinder S Sandhu, David M Kingsley, Eileen G Hoal, Xiao Liu, Mark J Daly, Marcus W Feldman, Christopher R Gignoux, Carlos D Bustamante, Brenna M Henn
Approximately 15 genes have been directly associated with skin pigmentation variation in humans, leading to its characterization as a relatively simple trait. However, by assembling a global survey of quantitative skin pigmentation phenotypes, we demonstrate that pigmentation is more complex than previously assumed, with genetic architecture varying by latitude. We investigate polygenicity in the KhoeSan populations indigenous to southern Africa who have considerably lighter skin than equatorial Africans. We demonstrate that skin pigmentation is highly heritable, but known pigmentation loci explain only a small fraction of the variance...
November 30, 2017: Cell
https://www.readbyqxmd.com/read/29192686/evidence-summary-the-relationship-between-oral-health-and-dementia
#18
B Daly, A Thompsell, J Sharpling, Y M Rooney, L Hillman, K L Wanyonyi, S White, J E Gallagher
This is the fourth and final paper of a series of reviews undertaken to explore the relationships between oral health and general medical conditions, in order to support teams within Public Health England, health practitioners and policy makers. This review aimed to explore the most contemporary evidence on whether poor oral health and dementia occurs in the same individuals or populations, to outline the nature of the relationship between these two health outcomes and to discuss the implication of any findings for health services and future research...
December 1, 2017: British Dental Journal
https://www.readbyqxmd.com/read/29190699/cost-effectiveness-of-expanding-childhood-routine-immunization-against-neisseria-meningitidis-serogroups-c-w-and-y-with-a-quadrivalent-conjugate-vaccine-in-the-african-meningitis-belt
#19
Andreas Kuznik, Garba Iliyasu, Mohammed Lamorde, Mustapha Mahmud, Baba M Musa, Ibrahim Nashabaru, Stephen Obaro, Idris Mohammed, Abdulrazaq G Habib
BACKGROUND: Neisseria meningitidis constitutes a major public health problem among countries in the African meningitis belt. Following regional vaccination campaigns for serogroup A and subsequent increases in protection against this serogroup, non-A serogroups such as C and W now pose significant epidemic threats, particularly in young children. OBJECTIVE: To evaluate the cost-effectiveness of broadening coverage from conjugate serogroup A to quadrivalent ACWY vaccination...
2017: PloS One
https://www.readbyqxmd.com/read/29189048/recall-of-structured-radiology-reports-is-significantly-superior-to-that-of-unstructured-reports
#20
Bryan W Buckley, Leslie Daly, Grainne N Allen, Carole A Ridge
OBJECTIVE: To measure recall of structured compared to unstructured radiology reports. METHODS: Institutional review board approval was obtained. Four hypothetical radiology reports, two structured and two unstructured, were created for the purposes of this study by an experienced consultant radiologist. The reports, each followed immediately by a multiple-choice questionnaire listing possible diagnoses from the report, were distributed to the members of two national physician associations using a web-based survey tool...
November 30, 2017: British Journal of Radiology
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