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Ependymoma

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https://www.readbyqxmd.com/read/29045967/-early-surgical-treatment-of-multi-segmet-intramedullary-cervical-spinal-cord-ependymoma
#1
C C Ma, G Z Lin, Z Y Wang
OBJECTIVE: To investigate the early clinical treatment and prognosis of multi-segment intramedullary cervical ependymoma. METHODS: Twenty patients with multi-segment (more than 3 segments) intramedullary spinal ependymoma (McCormic grade I) were microsurgically treated with assistance of intraoperative neuroelectrophysiological monitoring. None of them received postoperative radiotherapy. Preoperatively all the patients underwent MRI examination and their neurologically function was assessed by McCormic classification method...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29029279/radical-staged-approach-to-extensive-posterior-fossa-pediatric-ependymoma-3-dimensional-operative-video
#2
Karol P Budohoski, Mathew R Guilfoyle, Damiano G Barone, Ramez W Kirollos, Rikin A Trivedi, Thomas Santarius
No abstract text is available yet for this article.
September 29, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29018939/-presacral-lesion-at-the-rima-ani
#3
C Seeling, C Hirte, A Scheuerle, P Möller, T F E Barth
A 26-year-old woman presented with a painful bulge at the rima ani. The tumor was located in the presacral region. Histological examination revealed a well-circumscribed biphenotypical tumor with papillary configured myxoid areas and strongly sclerosing regions. This case of a myxopapillary ependymoma is a rare example of a myxoid neoplastic lesion in the sacral region.
October 10, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28990708/astroblastoma-a-distinct-tumor-entity-characterized-by-alterations-of-the-x-chromosome-and-mn1-rearrangement
#4
Takanori Hirose, Sumihito Nobusawa, Kazuhiko Sugiyama, Vishwa J Amatya, Naomi Fujimoto, Atsushi Sasaki, Yoshiki Mikami, Akiyoshi Kakita, Shinya Tanaka, Hideaki Yokoo
Astroblastoma is a rare, enigmatic tumor of the central nervous system (CNS) which shares some clinicopathologic aspects with other CNS tumors, especially ependymoma. To further clarify the nature of astroblastoma, we performed clinicopathologic and molecular genetic studies on eight cases of astroblastoma. The median age of the patients was 14.5 years, ranging from 5 to 60 years, and seven of the patients were female. All tumors arose in the cerebral hemisphere and radiologically appeared to be well-bordered, nodular tumors often associated with cystic areas and contrast-enhancement...
October 9, 2017: Brain Pathology
https://www.readbyqxmd.com/read/28973691/high-grade-glioma-is-not-a-feature-of-neurofibromatosis-type-2-in-the-unirradiated-patient
#5
Andrew T King, Scott A Rutherford, Charlotte Hammerbeck-Ward, Simon K Lloyd, Simon M Freeman, Omar N Pathmanaban, Monica Rodriguez-Valero, Owen M Thomas, Roger D Laitt, Stavros Stivaros, Mark Kellett, D Gareth Evans
BACKGROUND: The Manchester criteria for neurofibromatosis type 2 (NF2) include a range of tumors, and gliomas were incorporated in the original description. The gliomas are now widely accepted to be predominantly spinal cord ependymomas. OBJECTIVE: To determine whether these gliomas include any cases of malignant glioma (WHO grade III and IV) through a database review. METHODS: The prospective database consists of 1253 patients with NF2. 1009 are known to be alive at last follow-up...
July 21, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28968159/pediatric-thalamic-gliomas-an-updated-review
#6
Avneesh Gupta, Nathan Shaller, Kathryn A McFadden
CONTEXT: - Neoplasms originating in the thalamus are rare overall (1% of all brain tumors); however, they comprise approximately 5% of pediatric intracranial tumors and approach 15% of all malignant pediatric intracranial tumors in some series. OBJECTIVE: - To update readers about the current understanding of the diverse histology, biology, and behavior of pediatric thalamic tumors. Histologic verification is now thought to be critical for planning treatment, and, as a result, biopsy and total/subtotal resections are much more common today than in the past...
October 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28945056/the-changing-landscape-of-ependymomas-diagnostic-and-treatment-approaches
#7
Isabelle M Germano, Ekkehard M Kasper
No abstract text is available yet for this article.
September 22, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28945055/adjuvant-treatments-for-ependymomas
#8
E Alton Sartor, Patrick Y Wen
Ependymomas are rare primary central nervous system tumors occurring in children and young adults. They can be indolent or locally aggressive depending on location, histology, and extent of resection. Treatment involves maximal surgical resection and usually focal radiation therapy, depending on the presence of residual disease and tumor grade. Chemotherapy has been studied for both adults and children but do not have an established role in adjuvant therapy. In both age groups, treatment with mainly cisplatin based regimens can be considered in the setting of residual disease after surgery or for salvage therapy when surgery or further radiation is not indicated...
September 22, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28945053/surgery-for-posterior-fossa-ependymomas-in-adults
#9
Yosef Laviv, Isabelle M Germano, Anand Mahadevan, Ekkehard M Kasper
Ependymomas of the posterior fossa in adults are relatively rare, represent less than 1% of adult intracranial gliomas. Most of the cases are WHO grade II. Due to their rarity, there are no randomized studies regarding the best management of these tumors. It seems that surgical resection has a major role in their management. Unlike the scenario in children, these tumors can be cured by gross total resection without adjuvant therapy in the majority of cases. Hence, knowing the different surgical approaches, with their pros and cons, is important in order to offer the patient the best treatment...
September 22, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28945051/radiologic-characteristics-of-ependymomas-a-case-based-approach
#10
David Khatami, Ekkehard M Kasper, Rafeeque Bhadelia, Rafael Rojas
The purpose of this paper is to interoduce and review the characteristic imaging features of ependymal neoplasms through a comprehensive case-based approach. Illustrated cases highlight both common and uncommon manifestations of CNS-ependymomas. The combination of imaging features, location of the tumor, and patient's demographics often allow the suggestion of ependymoma as a lead entity in the differential diagnosis. However, significant overlap exists between the radiologic characteristics of ependymomas and those of other tumors commonly encountered in the same locations, which can pose a challenge for a definitive diagnosis based on imaging alone...
September 22, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28943417/giant-cell-ependymoma-of-the-lateral-ventricle-case-report-literature-review-and-analysis-of-prognostic-factors-and-genetic-profile
#11
Hirokazu Takami, Christopher Graffeo, Avital Perry, Aditya Raghunathan, Robert B Jenkins, Caterina Giannini, Terry C Burns
Giant cell ependymoma (GCE) is a rare primary CNS neoplasm. We report a case of GCE arising in the lateral ventricle. A 22-year-old female presented with generalized seizures. MRI demonstrated a diffuse, non-enhancing, multi-cystic mass centered in the atrium of the right lateral ventricle with extension throughout the frontal and temporal horns. An initial subtotal resection yielded the signature biphasic pattern of GCE. The dominant component contained pleomorphic, bizarre-appearing giant cells with low mitotic index, and a minor component comprised monomorphic, highly cellular, mitotically active cells that formed perivascular pseudorosettes...
September 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28942746/rapid-autopsy-of-a-patient-with-recurrent-anaplastic-ependymoma
#12
Katharine Rae Lange, Cheryl Fischer, Prajwal Rajappa, Scott Connors, David Pisapia, Jeffrey P Greenfield, Himisha Beltran, Mark Rubin, Juan Miguel Mosquera, Yasmin Khakoo
OBJECTIVE: Our aim was to outline a procedure for obtaining a rapid autopsy in order to collect high-quality postmortem tissue for genomic analysis. METHODS: This report details a bi-institutional collaborative effort to coordinate a rapid autopsy for a pediatric patient who had died at home. We discuss the scientific rationale for offering a rapid autopsy to caregivers of pediatric patients as well as parental perspectives on broaching the subject of autopsy. We then review the logistics and coordination involved with planning a rapid autopsy and the sequence of events needed to maximize tissue quality...
September 25, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28941523/a-review-of-visual-and-oculomotor-outcomes-in-children-with-posterior-fossa-tumors
#13
Crandall E Peeler
Tumors of the posterior fossa represent the most common solid malignancy of childhood and can affect the visual system in several ways. This article outlines the relevant visual anatomy affected by these tumors and reviews the visual and oculomotor outcomes associated with the following 3 most common tumor types-medulloblastoma, juvenile pilocytic astrocytoma, and ependymoma. The available data suggest that the rate of permanent vision loss is low (5.9%-8.3%), with patients having juvenile pilocytic astrocytoma demonstrating the best outcomes...
May 2017: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/28935546/fluorescein-guided-resection-of-intramedullary-spinal-cord-tumors-results-from-a-preliminary-multicentric-retrospective-study
#14
Francesco Acerbi, Claudio Cavallo, Karl-Michael Schebesch, Mehmet Osman Akcakaya, Camilla de Laurentis, Mustafa Kemal Hamamcioglu, Morgan Broggi, Alexander Brawanski, Jacopo Falco, Roberto Cordella, Paolo Ferroli, Telat Kiris, Julius Höhne
INTRODUCTION: IMSCTs are rare heterogenous lesions usually enhancing at pre-operative MRI, due to a damaged BBB. SF is a dye that accumulates in areas of the CNS with a damaged BBB. Given the pattern of MRI contrast-enhancement of the majority of IMSCTs, the use of this fluorescent tracer could improve tumor visualization and quality of resection. In this paper, we present the first experience on the application of fluorescein-guided technique for surgical removal of IMSCTs. METHODS: 11 patients (6 males, 5 females, mean age 50...
September 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28923150/you-re-the-flight-surgeon
#15
(no author information available yet)
McCoy RP. You're the flight surgeon: myxopapillary ependymoma. Aersop Med Hum Perform. 2017; 88(10):970-973.
October 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28918679/relating-the-proton-relative-biological-effectiveness-to-tumor-control-and-normal-tissue-complication-probabilities-assuming-interpatient-variability-in-%C3%AE-%C3%AE
#16
Harald Paganetti
BACKGROUND: Proton therapy uses a constant relative biological effectiveness (RBE) of 1.1. The use of variable RBE values has been suggested but is currently not feasible due to uncertainties. The impact of variable RBE has solely been studied using dosimetric indices. This work elucidates the impact of RBE variations on tumor control and normal tissue complication probabilities (TCP/NTCP). METHODS: Models to estimate TCP and NTCP were used in combination with an empirical proton RBE model...
September 18, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28900844/a-pilot-study-on-the-use-of-cerebrospinal-fluid-cell-free-dna-in-intramedullary-spinal-ependymoma
#17
Ian David Connolly, Yingmei Li, Wenying Pan, Eli Johnson, Linya You, Hannes Vogel, John Ratliff, Melanie Hayden Gephart
Cerebrospinal fluid (CSF) represents a promising source of cell-free DNA (cfDNA) for tumors of the central nervous system. A CSF-based liquid biopsy may obviate the need for riskier tissue biopsies and serve as a means for monitoring tumor recurrence or response to therapy. Spinal ependymomas most commonly occur in adults, and aggressive resection must be delicately balanced with the risk of injury to adjacent normal tissue. In patients with subtotal resection, recurrence commonly occurs. A CSF-based liquid biopsy matched to the patient's spinal ependymoma mutation profile has potential to be more sensitive then surveillance MRI, but the utility has not been well characterized for tumors of the spinal cord...
September 12, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28895660/epidemiology-molecular-classification-and-who-grading-of-ependymoma
#18
Jens-Martin Hübner, Marcel Kool, Stefan M Pfister, Kristian W Pajtler
Ependymoma can arise throughout all compartments of the central nervous system with prevalence for intracranial and spinal location in children and adults, respectively. The current histopathology based WHO grading system distinguishes grade I, II 'classic', and III 'anaplastic' ependymoma. However, analysis of multiple cohorts of intracranial ependymoma demonstrate a wide variance in the utility of the grade II versus grade III distinction as a prognostic marker that may additionally be confounded by the anatomic compartment...
September 8, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28890044/recursive-partitioning-analysis-for-disease-progression-in-adult-intracranial-ependymoma-patients
#19
Sang Woo Song, Yun-Sik Dho, Jin Wook Kim, Yong Hwy Kim, Sun Ha Paek, Dong Gyu Kim, Hee-Won Jung, Sung-Hye Park, Seung Hong Choi, Tae Min Kim, Soon-Tae Lee, Il Han Kim, Sang Hyung Lee, Chul-Kee Park
Intracranial ependymomas are rare tumors in adults. Although recent advancements from demographic, clinical, and biological studies provide new perspectives on this rare tumor, they are not yet widely applied in clinical practice. Currently, most ependymoma patients are treated in the same way: via surgical resection with adjuvant radiation therapy. However, it is reasonable to apply more aggressive treatment for high-risk patients. From this point of view, we performed a study to investigate risk grouping for disease progression of intracranial ependymomas in adults...
September 7, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28885433/put-away-your-microscopes-the-ependymoma-molecular-era-has-begun
#20
Stephen C Mack, Michael D Taylor
PURPOSE OF REVIEW: To synthesize, integrate, and comment on recent research developments to our understanding of the molecular basis of ependymoma (EPN), and to place this in context with current treatment and research efforts. RECENT FINDINGS: Our recent understanding of the histologically defined molecular entity EPN has rapidly advanced through genomic, transcriptomic, and epigenomic profiling studies. SUMMARY: These advancements lay the groundwork for development of future EPN biomarkers, models, and therapeutics...
November 2017: Current Opinion in Oncology
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