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Ependymoma

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https://www.readbyqxmd.com/read/29682026/prognostic-implications-of-histological-clear-cells-in-high-grade-intracranial-ependymal-tumors-a-retrospective-analysis-from-a-tertiary-care-hospital-in-pakistan
#1
Fauzan Alam Hashmi, Hamid Hussain Rai, Muhammad Faheem Khan, Muhammad Ehsan Bari
Background: Clear cell variant in ependymal tumors is rare. We aimed to compare the features and outcome of the World Health Organization (WHO) Grade 3 ependymal tumors with clear cells to the WHO Grade 3 classic anaplastic ependymoma (AE). Materials and Methods: A retrospective cohort study conducted at the Department of Neurosurgery, Aga Khan University, Pakistan, from 2003 to 2013. The medical records and radiology of patients with proven histopathology were reviewed...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681099/2016-children-s-tumor-foundation-conference-on-neurofibromatosis-type-1-neurofibromatosis-type-2-and-schwannomatosis
#2
Michael J Fisher, Allan J Belzberg, Peter de Blank, Thomas De Raedt, Florent Elefteriou, Rosalie E Ferner, Marco Giovannini, Gordon J Harris, Michel Kalamarides, Matthias A Karajannis, AeRang Kim, Conxi Lázaro, Lu Q Le, Wei Li, Robert Listernick, Staci Martin, Helen Morrison, Eric Pasmant, Nancy Ratner, Elisabeth Schorry, Nicole J Ullrich, David Viskochil, Brian Weiss, Brigitte C Widemann, Yuan Zhu, Annette Bakker, Eduard Serra
Organized and hosted by the Children's Tumor Foundation (CTF), the Neurofibromatosis (NF) conference is the premier annual gathering for clinicians and researchers interested in neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis (SWN). The 2016 edition constituted a blend of clinical and basic aspects of NF research that helped in clarifying different advances in the field. The incorporation of next generation sequencing is changing the way genetic diagnostics is performed for NF and related disorders, providing solutions to problems like genetic heterogeneity, overlapping clinical manifestations, or the presence of mosaicism...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29678196/astroblastoma-a-rare-and-challenging-tumor-a-case-report-and-review-of-the-literature
#3
Nawal Hammas, Nadia Senhaji, My Youssef Alaoui Lamrani, Sanae Bennis, Elfaiz Mohamed Chaoui, Hind El Fatemi, Laila Chbani
BACKGROUND: Astroblastoma is a controversial and an extremely rare central nervous system neoplasm. Although its histogenesis has been clarified recently, controversies exist regarding its cellular origin and validity as a distinct entity. Because of its extreme rarity and because its common features are shared with other glial neoplasms, this tumor is prone to misdiagnosis and remains challenging not only in terms of diagnosis and classification but also in the subsequent management...
April 21, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29665752/histopathologic-findings-in-canine-pituitary-glands
#4
Margaret A Miller, David S Bruyette, J Catharine Scott-Moncrieff, Tina Jo Owen, José A Ramos-Vara, Hsin-Yi Weng, Andrea L Vanderpool, Annie V Chen, Linda G Martin, Deidre M DuSold, Sina Jahan
To optimize the histologic evaluation of hypophysectomy specimens, sections of 207 canine pituitary glands (196 postmortem, 11 hypophysectomy specimens) were reviewed. Adenohypophyseal proliferation was the most common (n = 79) lesion. Proliferative lesions were sparsely to densely granulated; the granules were usually basophilic to chromophobic and periodic acid-Schiff-positive. Adenohypophyseal proliferation was classified as hyperplasia (n = 40) if ≤2 mm diameter with intact reticulin network, as microadenoma (n = 22) for 1-5 mm homogeneous nodules with lost reticulin network, or as macroadenoma (n = 17) for larger tumors...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29658967/identification-of-microrna-signature-in-different-pediatric-brain-tumors
#5
Marwa Tantawy, Mariam G Elzayat, Dina Yehia, Hala Taha
Understanding pediatric brain tumor biology is essential to help on disease stratification, and to find novel markers for early diagnosis. MicroRNA (miRNA) expression has been linked to clinical outcomes and tumor biology. Here, we aimed to detect the expression of different miRNAs in different pediatric brain tumor subtypes to discover biomarkers for early detection and develop novel therapies. Expression of 82 miRNAs was detected in 120 pediatric brain tumors from fixed-formalin paraffin-embedded tissues, low-grade glioma, high-grade glioma, ependymoma, and medulloblastoma, using quantitative real-time PCR...
January 2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29624145/surgical-decision-making-in-the-management-of-childhood-tumors-of-the-cns-disseminated-at-presentation
#6
Matthew A Kirkman, Richard Hayward, Kim Phipps, Kristian Aquilina
OBJECTIVE It is relatively unusual for pediatric CNS tumors to be disseminated at presentation, and the literature on the clinical features, management, and outcomes of this specific group is scarce. Surgical management in this population is often challenging, particularly in the presence of hydrocephalus. The authors present their recent experience of treating pediatric CNS tumors that were disseminated at presentation, and they compare these lesions with focal tumors. METHODS The authors performed a retrospective review of prospectively collected data on children presenting to a tertiary center between 2003 and 2016 inclusive...
April 6, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29617945/intracranial-neoplasms-in-the-first-year-of-life-results-of-a-third-cohort-of-patients-from-a-single-institution
#7
Sebastian M Toescu, Gregory James, Kim Phipps, Owase Jeelani, Dominic Thompson, Richard Hayward, Kristian Aquilina
BACKGROUND: Brain tumors in the first year of life are rare and their management remains challenging. OBJECTIVE: To report on the contemporary management of brain tumors in infants with reference to previous series from our institution. METHODS: Retrospective cohort study design. Electronic/paper case note review of all brain tumors diagnosed at our institution in children aged <1 yr since the publication of our previous series. RESULTS: Ninety-eight patients were seen...
April 3, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29613896/neoplastic-myelopathies
#8
Jing Wu, Surabhi Ranjan
PURPOSE OF REVIEW: This article discusses the diagnosis and management of neoplasms that affect the spinal cord as well as spinal cord disorders that can occur due to cancer treatments. RECENT FINDINGS: Neoplastic myelopathies are uncommon neurologic disorders but cause significant morbidity when they occur. Primary spinal cord tumors can be classified into intramedullary, intradural extramedullary, or extradural tumors. Diffuse gliomas and ependymal tumors are the most common intramedullary tumors...
April 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29610008/surgical-outcomes-of-spinal-cord-and-cauda-equina-ependymoma-postoperative-motor-status-and-recurrence-for-each-who-grade-in-a-multicenter-study
#9
Kazuyoshi Kobayashi, Kei Ando, Fumihiko Kato, Tokumi Kanemura, Koji Sato, Mitsuhiro Kamiya, Yoshihiro Nishida, Naoki Ishiguro, Shiro Imagama
BACKGROUND: The goals of the study are to analyze postoperative outcomes and recurrence in cases of spinal cord and cauda equina ependymoma in each World Health Organization (WHO) Grade, and to examine the influence of extent of surgical removal on prognosis. Spinal ependymoma has a relatively high frequency among intramedullary spinal cord tumors. The tumor is classified in WHO guidelines as grades I, II, and III, but few studies have examined postoperative prognosis based on these grades...
March 30, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29608701/stereotactic-radiosurgery-for-intracranial-ependymomas-an-international-multicenter-study
#10
Hideyuki Kano, Yan-Hua Su, Hsiu-Mei Wu, Gabriela Simonova, Roman Liscak, Or Cohen-Inbar, Jason P Sheehan, Antonio Meola, Mayur Sharma, Gene H Barnett, David Mathieu, Lucas T Vasas, Anthony M Kaufmann, Rachel C Jacobs, L Dade Lunsford
BACKGROUND: Stereotactic radiosurgery (SRS) is a potentially important option for intracranial ependymoma patients. OBJECTIVE: To analyze the outcomes of intracranial ependymoma patients who underwent SRS as a part of multimodality management. METHODS: Seven centers participating in the International Gamma Knife Research Foundation identified 89 intracranial ependymoma patients who underwent SRS (113 tumors). The median patient age was 16...
March 28, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29604507/confocal-scanning-microscopy-provides-rapid-detailed-intraoperative-histological-assessment-of-brain-neoplasms-experience-with-106-cases
#11
Nikolay L Martirosyan, Joseph Georges, Jennifer M Eschbacher, Evgenii Belykh, Alessandro Carotenuto, Robert F Spetzler, Peter Nakaji, Mark C Preul
OBJECTIVES: Frozen section histological analysis is currently the mainstay for intraprocedural tissue diagnosis during the resection of intracranial neoplasms and for evaluating tumor margins. However, frozen sections are time-consuming and often do not reveal the histological features needed for final diagnosis when compared with permanent sections. Confocal scanning microscopy (CSM) with certain stains may be a valuable technology that can add rapid and detailed histological assessment advantage for the neurosurgical operating room...
March 21, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29581022/neuro-endoscopic-cylinder-surgery-and-5-aminolevulinic-acid-5-ala-photodynamic-diagnosis-of-deep-seated-intracranial-lesions
#12
Jungsu Choo, Kazuhito Takeuchi, Yuichi Nagata, Fumiharu Ohka, Yugo Kishida, Tadashi Watanabe, Yusuke Satoh, Tetsuya Nagatani, Kyozo Kato, Toshihiko Wakabayashi, Atsushi Natsume
BACKGROUND: Microscopic detection of intracranial brain tumors with 5-aminolevulinic acid (5-ALA) has proven extremely useful, and reports the use of 5-ALA have recently increased. However, few reports have described 5-ALA photodynamic diagnosis (PDD) using a neuro-endoscope. We performed neuro-endoscopic 5-ALA PDD for various brain lesions and present a procedure using only a neuro-endoscope. METHODS: We describe the diagnosis of 20 intracranial brain lesion cases with a 5-ALA-guided fluorescence endoscope...
March 23, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29571787/advantages-of-high-b-value-diffusion-weighted-imaging-for-preoperative-differential-diagnosis-between-embryonal-and-ependymal-tumors-at-3-t-mri
#13
Takeshi Takayasu, Fumiyuki Yamasaki, Yuji Akiyama, Megu Ohtaki, Taiichi Saito, Ryo Nosaka, Motoki Takano, Kazuhiko Sugiyama, Kaoru Kurisu
PURPOSE: It is often difficult to distinguish between embryonal and ependymal tumors using conventional MR imaging. The apparent diffusion coefficient (ADC) calculated from diffusion-weighted images (DWI) has been widely used for diagnosis, but its usefulness for differential diagnosis between embryonal and ependymal tumors has not been determined yet. Both DWI properties and ADC values of these two types of tumor at regular and high b-values on a 3 T MR scanner were retrospectively reviewed...
April 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29571594/occurrence-of-neoplasms-in-individuals-with-congenital-severe-gh-deficiency-from-the-itabaianinha-kindred
#14
Cindi G Marinho, Lívia M Mermejo, Roberto Salvatori, João A Assirati, Carla R P Oliveira, Elenilde G Santos, Ângela C G B Leal, Cynthia S Barros-Oliveira, Nayra P Damascena, Carlos A Lima, Catarine T Farias, Ayrton C Moreira, Manuel H Aguiar-Oliveira
Growth hormone (GH) and the insulin-like growth factor I (IGF-I) have cell proliferative and differentiation properties. Whether these hormones have a role in mutagenesis is unknown. Nevertheless, severe IGF-I deficiency seems to confer protection against the development of neoplasms. Here, we report five cases of adult patients with severe and congenital isolated GH deficiency (IGHD) due to the c.57+1G>A mutation in the GHRH receptor gene, who developed tumors. Four GH-naïve subjects presented skin tumors: a 42-year-old man with a fibroepithelial polyp, a 53-year-old woman and two men (59 and 56 years old) with epidermoid skin cancers...
March 12, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29565756/treatment-challenges-and-outcomes-for-pediatric-intracranial-ependymoma-at-a-single-institution-in-iran
#15
Maryam Tashvighi, Azim Mehrvar, Amir Abbas Hedayati Asl, Narjes Mehrvar, Raheb Ghorbani, Ali Naderi, Mardawig Alebouyeh, Erfan Sattary, Naghmeh Niktoreh Mofrad, Ibrahim Qaddoumi, Mohammad Faranoush
BACKGROUND: The scarcity of information on pediatric ependymoma in Iran motivated this study. Our main objectives were to determine outcomes, identify clinical management challenges at a nongovernment hospital in Iran, and devise guidelines for improving care. PROCEDURE: A retrospective chart review was performed for pediatric patients with ependymoma who were younger than 15 years and treated at MPCTRC between 2007 and 2015. Records included patient demographics, treatment regimens used, duration of follow-up, and outcomes...
March 22, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29548057/ependymoma
#16
Elizabeth R Gerstner, Kristian W Pajtler
Ependymoma can arise throughout the whole neuraxis. In children, tumors predominantly occur intracranially, whereas the spine is the most prevalent location in adults. Significant variance in the grade II versus grade III distinction of ependymomas has led to the acknowledgment that the clinical utility of histopathological classification is limited. Epigenomic profiling efforts have identified molecularly distinct groups of ependymomas that adequately reflect the biological, clinical, and histopathological heterogeneities across anatomical compartments, age groups, and grades...
February 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29548047/practical-implications-of-the-updated-who-classification-of-brain-tumors
#17
Maria Martinez-Lage, Felix Sahm
The updated 2016 WHO classification of Central Nervous System tumors introduced a novel concept of neuropathology diagnostics. Molecular parameters are now included into the definition of several entities. This evolution from a previously purely histology-based classification to an integrated approach of histology and genetic characteristics has implications in daily diagnostic and clinical practice. Both the spectrum of diagnostic workup demanded from the neuropathologist and the range of relevant markers to be considered by clinicians and clinical investigators have increased...
February 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29537768/childhood-cancer-incidence-in-canada-demographic-and-geographic-variation-of-temporal-trends-1992-2010
#18
Lin Xie, Jay Onysko, Howard Morrison
INTRODUCTION: Surveillance of childhood cancer incidence trends can inform etiologic research, policy and programs. This study presents the first population-based report on demographic and geographic variations in incidence trends of detailed pediatric diagnostic groups in Canada. METHODS: The Canadian Cancer Registry data were used to calculate annual age-standardized incidence rates (ASIRs) from 1992 to 2010 among children less than 15 years of age by sex, age and region for the 12 main diagnostic groups and selected subgroups of the International Classification of Childhood Cancer (ICCC), 3rd edition...
March 2018: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29534265/-retinal-astrocytic-hamartoma-in-neurofibromatosis-type-2-metaanalysis-and-a-case-report
#19
Daniela Aneta Starosta, Birgit Lorenz
BACKGROUND: Neurofibromatosis type 2 (NF2) is a genetic condition with an autosomal dominant pattern of inheritance and incomplete penetrance. It is characterized by multiple benign tumors of the central and peripheral nervous system including astrocytomas, ependymomas, meningeomas, and schwannomas, among which bilateral vestibular schwannomas are the most frequent. Among ocular manifestations of NF2, juvenile subcapsular cataract is the most common followed by epiretinal membranes and combined hamartomas of the retina and retinal pigment epithelium...
March 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29526067/spinal-cord-subependymoma-surgery-a-multi-institutional-experience
#20
Woon Tak Yuh, Chun Kee Chung, Sung-Hye Park, Ki-Jeong Kim, Sun-Ho Lee, Kyoung-Tae Kim
OBJECTIVE: A spinal cord subependymoma is an uncommon, indolent, benign spinal cord tumor. It is radiologically similar to a spinal cord ependymoma, but surgical findings and outcomes differ. Gross total resection of the tumor is not always feasible. The present study was done to determine the clinical, radiological and pathological characteristics of spinal cord subependymomas. METHODS: We retrospectively reviewed the medical records of ten spinal cord subependymoma patients (M : F=4 : 6; median 38 years; range, 21-77) from four institutions...
March 2018: Journal of Korean Neurosurgical Society
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