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Ependymoma

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https://www.readbyqxmd.com/read/28213194/subcortical-mapping-using-an-electrified-cusa-in-pediatric-supratentorial-surgery
#1
Jonathan Roth, Akiva Korn, Yifat Bitan-Talmor, Rivka Kaufman, Margaret Ekstein, Shlomi Constantini
BACKGROUND: Intraoperative electrophysiology is increasingly used for various lesion resections, both in adult and pediatric brain surgery. Subcortical mapping is often used in adult surgery when lesions lie in proximity to the corticospinal tract (CST). We describe a novel technique of continuous subcortical mapping using an electrified Cavitron UltraSonic Aspirator (CUSA) in children with supratentorial lesions. METHODS: We evaluated the method of subcortical mapping using a CUSA as a stimulation probe...
February 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28195245/ependymoma-with-diffuse-signet-ring-features-report-of-a-case-and-review-of-the-literature
#2
L Cima, S Beccari, C Ghimenton, G Pinna, A Beltramello, M Chilosi, M Brunelli, A Eccher
Signet-ring cell ependymoma is a rare variant of ependymoma with only seven cases described in literature. Biological behavior and prognosis of this entity are not well-known until now. We present a case of a 49-year-old female with a history of headache and gait instability. Magnetic resonance imaging showed an upper cervical tumor with cystic component and mural nodule. The patient underwent surgery. Microscopically some cells displayed an eccentric nucleus compressed to the periphery by vacuolated cytoplasm...
March 2016: Pathologica
https://www.readbyqxmd.com/read/28193095/intraocular-ependymoma-with-blood-filled-spaces
#3
Aditi Dewan, Ravindra Kumar Saran, Smriti Nagpal Gupta, Deepanjali Arya, Ruchi Goel
Intraocular glial lesions are rare and include retinal gliosis, hamartomas, and astrocytomas and rarely ependymomas. Ependymomas are slow-growing glial tumors preferentially arising in the central nervous system (CNS), occasionally presenting at sites outside the CNS, with only 2 cases of primary retinal ependymoma reported till date. We report herein the third such case of a 20-year-old male who presented with a painful blind eye. The enucleated specimen showed presence of a glial tumor with cells arranged in sheets as well as few true rosettes and pseudo-rosettes and an immunohistochemical profile similar to a classical ependymoma at usual sites in the CNS...
February 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28182061/intraoperative-squash-cytology-and-histology-of-giant-cell-ependymoma-a-diagnostic-dilemma
#4
Ebru Cakir, Ulku Kucuk, Ayca Ersen, Emel E Pala, Mehmet Senoglu, Ali O Binatli, Zubeyde Yildirim
Giant cell ependymomas (GCE) are extremely rare tumors, with 24 cases described in the literature. Squash cytology is a rapid, reliable, simple technique for intraoperative consultation in neurosurgical practice. We describe a rare case of GCE arising at level of L4-L5 in a 66-year-old woman and discuss the cytologic/histologic features. Intraoperative smears were highly cellular with a prominent fibrillary background and exhibited papillary structures and sheets composed of highly atypical and bizarre cells...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28180935/clinicopathological-features-and-microsurgical-outcomes-for-giant-pediatric-intracranial-tumor-in-60-consecutive-cases
#5
Ailing Guo, Vigneyshwar Suresh, Xianzhi Liu, Fuyou Guo
PURPOSE: Giant pediatric intracranial tumor (GPIT) remains to be a challenging disease with high morbidity and mortality. METHODS: The clinical data of 60 patients under 18 years of age operated on with GPIT (≥5 cm in diameter) were retrospectively analyzed. RESULTS: Gross total resection was achieved in 46 cases (77%) and subtotal resection was obtained in 14 cases (23%). Ninety percent (47/52) of the cases with obstructive hydrocephalus were resolved remarkably and only 10% (5/52) of the patients needed a ventriculoperitoneal shunt after tumor resection...
February 8, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28162253/-intramedullary-ependymomas-a-french-retrospective-multicenter-study-of-221%C3%A2-cases
#6
N Aghakhani, M Messerer, P David, A Herbrecht, F Parker
AIM: Intramedullary ependymomas (IE) are the most frequent intramedullary tumors in the adult population. The gold standard treatment is to obtain gross total removal without any new postoperative neurological deficit. The authors report the results of a multicenter series with a long-term follow-up and the analysis of clinical, radiological, surgical data as well as the complementary treatments. MATERIALS AND METHODS: A retrospective analysis of adult patients with IE operated on between January 1984 and December 2011 at 7 French centers (Bordeaux, Kremlin-Bicêtre, Lille, Lyon, Marseille, Montpellier, Nice, and Nîmes) was performed...
February 2, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28161014/neuroglial-intramedullary-tumors-the-collaboration-between-neurosurgeons-and-neuropathologists
#7
G Cossu, C Lacroix, C Adams, R T Daniel, F Parker, M Messerer
Intramedullary tumors constitute approximately 5% of spinal tumors and about 80% are of neuroglial origin. We reviewed our series of adult patients with spinal neuroglial intramedullary tumors operated on between 1984 and 2011 at the neurosurgical department of Bicêtre hospital. The histopathological records for 196 patients were retrospectively analyzed. The majority of tumors were ependymomas (68%) and astrocytomas (27.5%). The importance of a proper and detailed neuropathological diagnosis is the key to define patient management...
February 1, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28156189/feline-glioma-a-retrospective-study-and-review-of-the-literature
#8
Daniel R Rissi, Andrew D Miller
Case series summary This study aimed to evaluate the pathologic and diagnostic features of 13 cases of feline glioma diagnosed at two veterinary diagnostic institutions over 16 years. A retrospective search was conducted using the laboratory information system. Selected cases were reviewed, tumors were classified according to the 2007 World Health Organization Classification of Tumours of the Central Nervous System, and tissue sections were submitted to an immunohistochemistry panel for further characterization...
February 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28104525/regional-spinal-cord-atrophy-is-associated-with-poor-outcome-after-surgery-on-intramedullary-spinal-cord-ependymoma-a-new-aspect-of-delayed-neurological-deterioration
#9
Bedjan Behmanesh, Florian Gessler, Johanna Quick-Weller, Andrea Spyrantis, Lioba Imöhl, Volker Seifert, Gerhard Marquardt
BACKGROUND: A considerable number of patients suffer delayed neurological deficits even after a successful removal of intramedullary spinal cord ependymoma. The underlying pathology remains unknown. Radiological findings could be an explanation for poor outcome after surgery. METHODS: We conducted a retrospective study of all cases treated from 1980 to 2016 in our department. Included were all patients with intramedullary spinal cord ependymoma treated with microsurgical excision...
January 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28096196/craniospinal-irradiation-using-helical-tomotherapy-for-central-nervous-system-tumors
#10
Sanziana R I Schiopu, Gregor Habl, Matthias Häfner, Sonja Katayama, Klaus Herfarth, Juergen Debus, Florian Sterzing
The aim of this study was to describe early and late toxicity, survival and local control in 45 patients with primary brain tumors treated with helical tomotherapy craniospinal irradiation (HT-CSI). From 2006 to 2014, 45 patients with central nervous system malignancies were treated with HT-CSI. The most common tumors were medulloblastoma in 20 patients, ependymoma in 10 patients, intracranial germinoma (ICG) in 7 patients, and primitive neuroectodermal tumor in 4 patients. Hematological toxicity during treatment included leukopenia Grades 1-4 (6...
January 17, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28093610/the-new-who-2016-classification-of-brain-tumors-what-neurosurgeons-need-to-know
#11
REVIEW
Rouzbeh Banan, Christian Hartmann
BACKGROUND: The understanding of molecular alterations of tumors has severely changed the concept of classification in all fields of pathology. The availability of high-throughput technologies such as next-generation sequencing allows for a much more precise definition of tumor entities. Also in the field of brain tumors a dramatic increase of knowledge has occurred over the last years partially calling into question the purely morphologically based concepts that were used as exclusive defining criteria in the WHO 2007 classification...
March 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28089483/patterns-of-failure-after-radiotherapy-for-pediatric-patients-with-intracranial-ependymoma
#12
Fatima Tensaouti, Anne Ducassou, Léonor Chaltiel, Stéphanie Bolle, Xavier Muracciole, Bernard Coche-Dequeant, Claire Alapetite, Valérie Bernier, Line Claude, Stéphane Supiot, Aymeri Huchet, Christine Kerr, Elisabeth le Prisé, Anne Laprie
PURPOSE: To investigate the patterns of failure after radiotherapy for pediatric intracranial ependymoma and their correlation with dose parameters. METHODS: Between 2000 and 2013, 206 patients were treated in France. MRI scans at relapse were registered to the original planning CTs for topographic analysis of failure patterns. To compare relapse patients (RP) with non relapse patients (NRP), several dose parameters were derived from dose volume histograms. RESULTS: Over a median follow-up of 53...
January 12, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28088216/immunohistochemical-features-of-giant-cell-ependymoma-of-the-filum-terminale-with-unusual-clinical-and-radiological-presentation
#13
Fernando Candanedo-Gonzalez, Cindy Sharon Ortiz-Arce, Samuel Rosales-Perez, Ana Lilia Remirez-Castellanos, Candelaria Cordova-Uscanga, Armando Gamboa-Dominguez
BACKGROUND: Giant cell ependymoma of the filum terminale is a rare variant, generally manifested as a well-circunscribed intradural mass with an indolent biological behavior. CASE PRESENTATION: We describe the case of a 48-year-old Mexican female who non-relevant past medical history, that developed a GCE of the filum terminale. Magnetic resonance imaging and computed tomography revealed the presence of an intra-axial tumor extending from L3 to L5 with extra-medullary invasion...
January 14, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28059629/extra-axial-ependymoma-of-the-cerebral-convexity-a-very-rare-intracranial-adult-tumor
#14
Soufiane Berhili, Abdellah Aissa, Selma Kadiri, Nadia Cherradi, Sanae El Majjaoui, Hanan El Kacemi, Tayeb Kebdani, Noureddine Benjaafar
Background Ependymomas are rare adult tumors that originate from the ventricular system or the ependymal surface of the central canal. Extra-axial supratentorial ependymomas are extremely rare, and only five cases have been reported to date in the English literature. Case presentation A 46-year-old previously healthy male presented with a gradual painless loss of vision in the right eye. Cerebral MRI showed a right parietal-occipital lesion resembling an atypical meningioma. Surgical resection was performed, and immunohistochemical staining results concluded that it was a very uncommon location of a grade 3 ependymoma...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28048899/we-fg-202-09-voxel-level-analysis-of-adverse-treatment-response-in-pediatric-patients-treated-for-ependymoma-with-passive-scattering-proton-therapy
#15
C Peeler, D Mirkovic, U Titt, D Grosshans, R Mohan
PURPOSE: We identified patients treated for ependymoma with passive scattering proton therapy who subsequently developed treatment-related imaging changes on MRI. We sought to determine if there is any spatial correlation between imaged response, dose, and LET. METHODS: A group of 14 patients treated for ependymoma were identified as having post-treatment MR imaging changes observable as T2-FLAIR hyperintensity with or without enhancement on T1 post-contrast sequences...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048662/su-f-t-206-proton-treatment-techniques-for-posterior-fossa-tumors-consequences-for-let-and-dose-volume-parameters-for-the-brainstem-and-organs-at-risk
#16
D Giantsoudi, J Adams, S MacDonald, H Paganetti
PURPOSE: In proton radiation therapy of posterior fossa tumors, to spare other sensitive structures, the preferred beam geometry results in placing the treatment field distal edge within or just beyond the brainstem, including in at least partially in the treatment volume. Concerns for brainstem toxicity are increased and a controversy exists as to weather the beam's distal edge should be placed within the brainstem or beyond it, to avoid elevated linear energy transfer (LET) and relative biological effectiveness (RBE) within the brainstem...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048024/su-f-t-116-predicting-iq-and-the-risk-of-hearing-loss-following-proton-versus-photon-radiotherapy-for-pediatric-brain-tumor-patients
#17
D Fortin, A Ng, D Tsang, M Sharpe, N Laperriere, D Hodgson
PURPOSE: The increased sparing of normal tissues in intensity modulated proton therapy (IMPT) compared to photon intensity modulated radiotherapy (IMRT) in brain tumor treatments should translate into improved neurocognitive outcomes. Models were used to estimate the intelligence quotient (IQ) and the risk of hearing loss 5 years post radiotherapy and to compare outcomes of proton against photon in pediatric brain tumors. METHODS: Patients who had received radical IMRT were randomly selected from our retrospective database: 10 cases each of craniopharyngioma, ependymoma and medulloblastoma, and 20 cases of glioma...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28041317/stereotactic-radiosurgery-for-intradural-spine-tumors-using-cone-beam-ct-image-guidance
#18
Andrés Monserrate, Benjamin Zussman, Alp Ozpinar, Ajay Niranjan, John C Flickinger, Peter C Gerszten
OBJECTIVE Cone-beam CT (CBCT) image guidance technology has been widely adopted for spine radiosurgery delivery. There is relatively little experience with spine radiosurgery for intradural tumors using CBCT image guidance. This study prospectively evaluated a series of intradural spine tumors treated with radiosurgery. Patient setup accuracy for spine radiosurgery delivery using CBCT image guidance for intradural spine tumors was determined. METHODS Eighty-two patients with intradural tumors were treated and prospectively evaluated...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28040793/tert-promoter-mutations-but-not-the-alternative-lengthening-of-telomeres-phenotype-are-present-in-a-subset-of-ependymomas-and-are-associated-with-adult-onset-and-progression-to-ependymosarcoma
#19
Fabienne Brügger, Matthias S Dettmer, Maja Neuenschwander, Aurel Perren, Ilaria Marinoni, Ekkehard Hewer
Genetic signatures related to telomere maintenance have emerged as powerful classifiers among CNS tumors. These include the alternative lengthening of telomeres (ALT) phenotype associated with mutations in the ATRX and DAXX genes and recurrent point mutations in the TERT gene promoter. We investigated a patient cohort covering the entire spectrum of childhood and adult ependymomas (n = 128), including subependymomas and myxopapillary ependymomas, for the presence of TERT promoter mutations, for loss of ATRX or DAXX expression by immunohistochemistry (as surrogates as underlying gene mutations), and for the ALT phenotype by fluorescence in situ hybridization (FISH)...
December 31, 2016: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28040529/primary-seeding-of-a-myxopapillary-ependymoma-is-it-a-different-disease-in-an-adult-population-case-report-and-review-of-the-literature
#20
Nickalus R Khan, Matthew VanLandingham, Thomas O'Brien, Frederick A Boop, Kenan Arnautović
Myxopapillary ependymoma (MPE) is a slow-growing tumor occurring most often in adults. It originates from the filum terminale in the area of the conus medullaris and cauda equina, and is considered a benign lesion. Despite this classification, however, recurrence after both partial and gross total resection is well known. In the pediatric population, primary MPE seeding is well documented and treated through gross total resection, followed by irradiation. In adults, however, primary MPE seeding is not recognized...
December 28, 2016: World Neurosurgery
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